Skin bacteriostatic cream and preparation method thereof

Abstract

The invention relates to the technical field of medicines, in particular to skin antibacterial cream and a preparation method thereof. In order to solve the technical problem, the technical scheme provided by the invention is as follows: the skin antibacterial cream is prepared by mixing the following raw materials in parts by weight: 0.06 to 1.1 parts of American cockroach extract, 0.06 to 1.1 parts of lithospermum extract, 8 to 35 parts of zinc oxide, 0.05 to 2.2 parts of borneol, 0.001 to 0.12 part of dichlorophenoxychlorophenol and 0.07 to 0.15 part of chlorhexidine acetate. Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 0.1 to 0.7 part of American cockroach extract, 0.1 to 0.7 part of radix arnebiae seu lithospermi extract, 12 to 32 parts of zinc oxide, 0.1 to 1.6 parts of borneol, 0.002 to 0.1 part of dichlorphenoxychlorophenol and 0.1 to 0.8 part of chlorhexidine acetate. The periplaneta americana ointment has the beneficial effects that the healing speed is high, the periplaneta americana extract can accelerate cell proliferation and migration, the wound healing time is shortened, and the wound healing time is averagely shortened by 30% or above. All the raw materials have a synergistic effect, so that pathogenic microorganisms can be effectively inhibited, the infection risk is reduced, granulation tissue formation and epithelization are promoted, and the healing quality is improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to a skin antibacterial ointment and its preparation method. Background Technology

[0002] Skin wounds are common in daily life and clinical medicine, such as pressure ulcers, diabetic foot, chronic leg ulcers, abrasions, burns, etc. If these wounds cannot heal in time and effectively, they may cause complications such as infection and ulceration, causing great pain to patients and increasing the difficulty of treatment for medical staff.

[0003] Currently, there are many types of drugs used for wound healing, but most of them have problems such as slow healing speed, poor effect, and cumbersome use. Some drugs may also cause adverse reactions such as skin irritation, making it difficult to meet the needs of patients and medical staff.

[0004] Therefore, developing a skin antibacterial ointment that can quickly promote wound healing, is effective, and is easy to use is of great practical significance. Summary of the Invention

[0005] To address the problems mentioned in the background art, the present invention aims to provide a skin antibacterial cream and its preparation method.

[0006] To solve the above-mentioned technical problems, the technical solution provided by the present invention is as follows: a skin antibacterial ointment and its preparation method, which is composed of the following raw materials in the indicated weight ratios: 0.06-1.1 parts of American cockroach extract, 0.06-1.1 parts of Lithospermum erythrorhizon extract, 8-35 parts of zinc oxide, 0.05-2.2 parts of borneol, 0.001-0.12 parts of dichlorophenoxychlorophenol, and 0.07-0.15 parts of chlorhexidine acetate.

[0007] Preferably, the weight ratio of the raw materials is as follows: 0.1-0.7 parts of American cockroach extract, 0.1-0.7 parts of Lithospermum erythrorhizon extract, 12-32 parts of zinc oxide, 0.1-1.6 parts of borneol, 0.002-0.1 parts of dichlorophenoxychlorophenol, and 0.1-0.8 parts of chlorhexidine acetate.

[0008] Preferably, the weight ratio of the raw materials is as follows: 0.2-0.5 parts of American cockroach extract, 0.2-0.5 parts of Lithospermum erythrorhizon extract, 15-25 parts of zinc oxide, 0.2-1.2 parts of borneol, 0.006-0.06 parts of dichlorophenoxychlorophenol, and 0.18-0.6 parts of chlorhexidine acetate.

[0009] The method for preparing the skin antibacterial cream is characterized by comprising the following steps:

[0010] S1: Weigh each raw material according to its weight;

[0011] S2: Grind zinc oxide into a fine powder and pass it through a 100-200 mesh sieve for later use;

[0012] S3: Take borneol, add an appropriate amount of ethanol to dissolve it, and obtain a borneol ethanol solution for later use;

[0013] S4: Mix the extracts of American cockroach, comfrey extract, dichlorophenoxychlorophenol, and chlorhexidine acetate, add an appropriate amount of purified water, and stir well to obtain mixture A;

[0014] S5: Add the zinc oxide fine powder obtained in step 2 to the mixture A and stir until uniform to obtain mixture B;

[0015] S6: Add the borneol ethanol solution obtained in step 3 to mixture B, stir well, and the skin antibacterial cream is obtained.

[0016] The functions of each raw material are as follows:

[0017] American cockroach extract: rich in various active peptides and growth factors (EGF, FGF), which can powerfully activate cell proliferation and migration in damaged areas, accelerate granulation tissue formation and epithelialization, and lay the foundation for rapid healing.

[0018] Comfrey extract: Its core component, shikonin, has powerful anti-inflammatory and antibacterial properties, which can effectively eliminate potential infection in wounds, significantly reduce inflammatory reactions such as redness, swelling, heat, and pain, and create a pure and stable healing microenvironment.

[0019] Zinc oxide: As a physical barrier, it forms a breathable protective layer on the wound, absorbs excess exudate, maintains a moderately moist environment, and also has mild astringent and antibacterial properties.

[0020] Borneol: It has strong penetrating power and can quickly relieve burning pain and itching, improve patient comfort, and at the same time help other active ingredients penetrate and improve overall bioavailability.

[0021] Dichlorophenoxychlorophenol: It has antibacterial properties and can further enhance the antibacterial effect of the ointment.

[0022] Chlorhexidine acetate: It has broad-spectrum antibacterial and bactericidal effects and can effectively inhibit pathogenic microorganisms such as Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0023] In the antibacterial skin cream of this invention, the various ingredients work synergistically to achieve the effects of "removing necrotic tissue, promoting tissue regeneration, and repairing wounds":

[0024] "Removing decay" and clearing the source: Comfrey extract and zinc oxide work together to effectively remove necrotic tissue, inhibit pathogenic microorganisms, and purify the wound.

[0025] Accelerated tissue regeneration: American cockroach extract powerfully drives cell regeneration and orderly collagen deposition, significantly shortening the healing cycle.

[0026] "Repair and Cure" Superior Effects: Camphor instantly relieves discomfort, while zinc oxide provides physical protection, working together to ensure a smooth and comfortable healing process, ultimately resulting in smaller scars, better texture, and better functional recovery.

[0027] The beneficial effects of this invention are:

[0028] Fast healing speed: The American cockroach extract in this invention can accelerate cell proliferation and migration, and significantly shorten the wound healing time. Experimental verification shows that compared with traditional methods, the wound healing time is shortened by an average of more than 30%.

[0029] Excellent healing effect: The synergistic effect of each ingredient can effectively inhibit pathogenic microorganisms, reduce the risk of infection, promote the formation of granulation tissue and epithelialization, improve the quality of healing, and make the healed scar smaller, with better texture and better functional recovery.

[0030] Easy to use: Simply apply evenly to the wound after cleaning. No complicated procedures are required, reducing the difficulty of use and making it convenient for patients to use on their own and for medical staff to perform clinical procedures.

[0031] It has a wide range of applications: it can be used to treat various wounds such as pressure ulcers, diabetic foot, chronic leg ulcers, abrasions, burns, electric shocks, frostbite, wound infections, chronic skin ulcers, non-healing postoperative wounds, chemical corrosion injuries, and phlebitis ulcers.

[0032] High safety: This invention uses natural extracts and safe and effective chemical raw materials. The formula is mild and is unlikely to cause adverse reactions such as skin irritation.

[0033] Obviously, based on the above description of the present invention, and according to common technical knowledge and conventional methods in the field, various other modifications, substitutions or alterations can be made without departing from the basic technical concept of the present invention.

[0034] The following detailed embodiments further illustrate the above-described content of the present invention. However, this should not be construed as limiting the scope of the present invention to the following examples. All technologies implemented based on the above-described content of the present invention fall within the scope of the present invention. Detailed Implementation

[0035] The present invention is illustrated below with specific embodiments, which are not intended to limit the scope of the invention.

[0036] Example 1

[0037] A skin antibacterial ointment is composed of the following ingredients in parts by weight: 0.2 parts of American cockroach extract, 0.2 parts of comfrey extract, 15 parts of zinc oxide, 0.2 parts of borneol, 0.006 parts of dichlorophenoxychlorophenol, and 0.18 parts of chlorhexidine acetate.

[0038] Its preparation method includes the following steps:

[0039] Weigh each raw material according to the above-mentioned weight proportions;

[0040] Grind zinc oxide into a fine powder and pass it through a 100-mesh sieve for later use;

[0041] Take borneol, add an appropriate amount of ethanol to dissolve it, and obtain a borneol ethanol solution for later use;

[0042] American cockroach extract, comfrey extract, dichlorophenoxychlorophenol, and chlorhexidine acetate were mixed, and an appropriate amount of purified water was added. The mixture was stirred evenly to obtain mixture A.

[0043] Add the zinc oxide fine powder obtained in step 2 to mixture A and stir until uniform to obtain mixture B;

[0044] Add the borneol ethanol solution obtained in step 3 to mixture B and stir well to obtain the skin antibacterial cream.

[0045] Example 2

[0046] A skin antibacterial cream is composed of the following ingredients in parts by weight: 0.5 parts of American cockroach extract, 0.5 parts of comfrey extract, 25 parts of zinc oxide, 1.2 parts of borneol, 0.06 parts of dichlorophenoxychlorophenol, and 0.6 parts of chlorhexidine acetate.

[0047] Its preparation method includes the following steps:

[0048] Weigh each raw material according to the above-mentioned weight proportions;

[0049] Grind the zinc oxide into a fine powder and pass it through a 200-mesh sieve for later use;

[0050] Take borneol, add an appropriate amount of ethanol to dissolve it, and obtain a borneol ethanol solution for later use;

[0051] American cockroach extract, comfrey extract, dichlorophenoxychlorophenol, and chlorhexidine acetate were mixed, and an appropriate amount of purified water was added. The mixture was stirred evenly to obtain mixture A.

[0052] Add the zinc oxide fine powder obtained in step 2 to mixture A and stir until uniform to obtain mixture B;

[0053] Add the borneol ethanol solution obtained in step 3 to mixture B and stir well to obtain the skin antibacterial cream.

[0054] Example 3

[0055] A skin antibacterial cream is composed of the following ingredients in parts by weight: 0.35 parts of American cockroach extract, 0.35 parts of comfrey extract, 20 parts of zinc oxide, 0.7 parts of borneol, 0.03 parts of dichlorophenoxychlorophenol, and 0.3 parts of chlorhexidine acetate.

[0056] Its preparation method includes the following steps:

[0057] Weigh each raw material according to the above-mentioned weight proportions;

[0058] Zinc oxide is pulverized into a fine powder and passed through a 150-mesh sieve for later use;

[0059] Take borneol, add an appropriate amount of ethanol to dissolve it, and obtain a borneol ethanol solution for later use;

[0060] American cockroach extract, comfrey extract, dichlorophenoxychlorophenol, and chlorhexidine acetate were mixed, and an appropriate amount of purified water was added. The mixture was stirred evenly to obtain mixture A.

[0061] Add the zinc oxide fine powder obtained in step 2 to mixture A and stir until uniform to obtain mixture B;

[0062] Add the borneol ethanol solution obtained in step 3 to mixture B and stir well to obtain the skin antibacterial cream.

[0063] American cockroach extract: rich in various active peptides and growth factors (EGF, FGF), which can powerfully activate cell proliferation and migration in damaged areas, accelerate granulation tissue formation and epithelialization, and lay the foundation for rapid healing.

[0064] Comfrey extract: Its core component, shikonin, has powerful anti-inflammatory and antibacterial properties, which can effectively eliminate potential infection in wounds, significantly reduce inflammatory reactions such as redness, swelling, heat, and pain, and create a pure and stable healing microenvironment.

[0065] Zinc oxide: As a physical barrier, it forms a breathable protective layer on the wound, absorbs excess exudate, maintains a moderately moist environment, and also has mild astringent and antibacterial properties.

[0066] Borneol: It has strong penetrating power and can quickly relieve burning pain and itching, improve patient comfort, and at the same time help other active ingredients penetrate and improve overall bioavailability.

[0067] Dichlorophenoxychlorophenol: It has antibacterial properties and can further enhance the antibacterial effect of the ointment.

[0068] Chlorhexidine acetate: It has broad-spectrum antibacterial and bactericidal effects and can effectively inhibit pathogenic microorganisms such as Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0069] In the antibacterial skin cream of this invention, the various ingredients work synergistically to achieve the effects of "removing necrotic tissue, promoting tissue regeneration, and repairing wounds":

[0070] "Removing decay" and clearing the source: Comfrey extract and zinc oxide work together to effectively remove necrotic tissue, inhibit pathogenic microorganisms, and purify the wound.

[0071] Accelerated tissue regeneration: American cockroach extract powerfully drives cell regeneration and orderly collagen deposition, significantly shortening the healing cycle.

[0072] "Repair and Cure" Superior Effects: Camphor instantly relieves discomfort, while zinc oxide provides physical protection, working together to ensure a smooth and comfortable healing process, ultimately resulting in smaller scars, better texture, and better functional recovery.

[0073] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0074] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

[0075] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A skin antibacterial cream, characterized in that, It is a mixture of the following raw materials in the indicated weight ratios: 0.06-1.1 parts of American cockroach extract, 0.06-1.1 parts of Lithospermum erythrorhizon extract, 8-35 parts of zinc oxide, 0.05-2.2 parts of borneol, 0.001-0.12 parts of dichlorophenoxychlorophenol, and 0.07-0.15 parts of chlorhexidine acetate.

2. The antibacterial skin cream according to claim 1, characterized in that, The weight ratio of the raw materials is as follows: 0.1-0.7 parts of American cockroach extract, 0.1-0.7 parts of Lithospermum erythrorhizon extract, 12-32 parts of zinc oxide, 0.1-1.6 parts of borneol, 0.002-0.1 parts of dichlorophenoxychlorophenol, and 0.1-0.8 parts of chlorhexidine acetate.

3. A skin antibacterial ointment according to any one of claims 1 to 2, characterized in that, The weight ratio of the raw materials is as follows: 0.2-0.5 parts of American cockroach extract, 0.2-0.5 parts of Lithospermum erythrorhizon extract, 15-25 parts of zinc oxide, 0.2-1.2 parts of borneol, 0.006-0.06 parts of dichlorophenoxychlorophenol, and 0.18-0.6 parts of chlorhexidine acetate.

4. A method for preparing the antibacterial skin cream according to any one of claims 1 to 3, characterized in that, Includes the following steps: S1: Weigh each raw material according to its weight; S2: Grind zinc oxide into a fine powder and pass it through a 100-200 mesh sieve for later use; S3: Take borneol, add an appropriate amount of ethanol to dissolve it, and obtain a borneol ethanol solution for later use; S4: Mix the extracts of American cockroach, comfrey extract, dichlorophenoxychlorophenol, and chlorhexidine acetate, add an appropriate amount of purified water, and stir well to obtain mixture A; S5: Add the zinc oxide fine powder obtained in step 2 to the mixture A and stir until uniform to obtain mixture B; S6: Add the borneol ethanol solution obtained in step 3 to mixture B and stir well to obtain the skin antibacterial cream.