Pathological section patch arranging device and method
By designing a pathological slide mounting device, continuous and single-layer slicing operations on pathological paraffin blocks were achieved, solving the problem of insufficient functionality in pathological slide detection in existing technologies and improving detection efficiency and accuracy.
Patent Information
- Application Number
- CN202511113551.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-11
- Publication Date
- 2025-10-31
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
In current pathological section examination processes, multi-slice machines cannot fully display the depth and extent of tumor infiltration along the intestinal wall when cutting pathological paraffin blocks, and single-layer sections are prone to missing 'skip lesions', resulting in insufficient functionality.
A pathological slide mounting and slicing device was designed, comprising a pathological slide mounting and slicing machine body, an adjustment and operation cavity, a slide mounting and slicing cavity, a transverse drive guide rail, an advance and retreat drive guide rail, and a slicing system. It achieves continuous and single-layer slicing operations through a large-span adjustment component and a micro-distance adjustment component, and combines two working states of the spiral slicing seat to adapt to the slicing requirements of pathological paraffin blocks.
It improves the efficiency and functionality of pathological section examination, effectively disperses stellate spots at lesions, meets the screening needs of mild symptoms in the initial pathological examination, supports optimized observation of local lesions that are already diseased, and reduces the error of section thickness.
Smart Images
Figure CN120869733A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of pathological testing technology, and more specifically, to a device and method for mounting pathological slides. Background Technology
[0002] Pathological examination: Diseased tissue is taken, fixed, dehydrated, embedded, sectioned, stained and prepared into thin sections, and the cell structure and tissue morphology are observed under a microscope; Specimen processing procedure: Sampling and fixation: The excised tissue was quickly fixed with 10% formalin to prevent putrefaction and deformation (ideal volume: 2.0cm × 2.0cm × 0.3cm).
[0003] Dehydration and clearing: After dehydration with graded alcohol, xylene becomes clear, allowing paraffin to fully penetrate the tissue.
[0004] Embedding and sectioning: Paraffin is embedded into blocks and sectioned to a thickness of 4–6 μm (standard diagnostic thickness) using a microtome.
[0005] Staining: HE staining (hematoxylin-eosin): The cell nucleus appears blue and the cytoplasm appears red, which is the basic diagnostic method.
[0006] Special staining: such as Masson (collagen fiber), PAS (glycogen), etc., to highlight specific structures.
[0007] Advanced detection technologies: Immunohistochemistry (IHC): Using antibodies to label specific proteins (such as tumor markers) to aid in typing (such as HER2 detection in breast cancer).
[0008] Molecular pathology: FISH detection of gene amplification (e.g., HER2) and PCR sequencing analysis of mutations (e.g., EGFR / KRAS).
[0009] Multicolor immunofluorescence: It can simultaneously label 7 proteins for the study of complex microenvironments.
[0010] Current methods for pathological slide examination involve using multi-slice microtome to thinly slice embedded paraffin blocks and then placing them in water for mounting. The slicing process often involves reciprocating motions, using glass slides as a support, and typically examining only a portion of the paraffin block. Therefore, in gastrointestinal tumor research, existing slicing methods cannot fully demonstrate the depth and extent of tumor infiltration along the intestinal wall, nor can they detect "skip lesions" due to segmented cutting of single-layer sections. Therefore, we propose a multifunctional pathological slide mounting device for cautious initial pathological screening, for monitoring disease progression, or for optimized detection. In light of this, we propose a pathological slide mounting device and method. Summary of the Invention
[0011] The purpose of this invention is to provide a whole-piece pathological slide mounting device and method to solve the technical problem of insufficient functionality of whole-piece pathological slide mounting.
[0012] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a pathological slide mounting and assembling device, comprising a pathological slide mounting and assembling machine body; the internal gap of the pathological slide mounting and assembling machine body forms an adjustment operation cavity and a slide mounting and assembling chamber; a transverse drive guide rail is provided at the upper end of the slide mounting and assembling chamber; a forward and backward drive guide rail is provided at the movable end of the transverse drive guide rail; a slitting system is provided at the movable end of the forward and backward drive guide rail; a movable stage for mounting pathological paraffin blocks is provided below the slitting system; the movable stage is mounted and connected to the pathological paraffin blocks via a mounting base; and the movable stage is mounted and connected to the pathological slide mounting and assembling machine body via a slitting and scraping guide rail; a slide mounting and assembling compartment is provided inside the pathological slide mounting and assembling machine body relative to the bottom of the slide mounting and assembling chamber; the slitting system includes a drive seat arranged at the movable end of the forward and backward drive guide rail; a center output unit, a drive unit, a large span adjustment component, and a micro-distance adjustment component are respectively provided on the drive seat.
[0013] This invention achieves adaptive adjustment of the slicing mechanism in the pathological slide mounting device by driving and adjusting the central output unit through a large-span adjustment component. This adjustment enables continuous slicing of paraffin blocks and single-layer slicing. These two different methods are used for initial pathological examinations with mild symptoms, effectively and efficiently slicing the pathological slides to address the scattered lesions and limited detection areas, thus improving the efficiency of slide mounting and whole-slice processing during the testing process. Furthermore, another method enables conventional single-layer slicing, facilitating screening and meeting the needs of observing local lesion deterioration in patients with existing disease. The combination of these two different slicing methods effectively improves the overall functionality of the pathological slide mounting device.
[0014] Preferably, the central output unit includes a central bushing A arranged on the drive seat via a bearing seat A; the inner wall of the central bushing A is provided with key teeth A; a secondary adjustment connecting seat is provided below the central bushing A via a directional sliding shaft; a secondary auxiliary bushing is provided on the secondary adjustment connecting seat at the same axial position relative to the central bushing A; wherein the inner surface of the secondary auxiliary bushing is provided with key teeth B; wherein the axial inner diameter clearance between the central bushing A and the secondary auxiliary bushing forms a sliding adjustment cavity; and a primary drive central shaft is keyed inside the sliding adjustment cavity.
[0015] Preferably, the drive unit includes a slitting drive motor arranged on one side of the drive seat; the output end of the slitting drive motor is provided with a drive synchronous pulley; wherein, the drive unit also includes a driven synchronous pulley fixed to the top of the bearing seat A; wherein, the primary drive central shaft, the central shaft sleeve A, and the secondary auxiliary shaft sleeve are all connected to the slitting drive motor through the bearing seat A, the drive synchronous pulley, the synchronous belt, and the drive synchronous pulley.
[0016] Preferably, the large span adjustment assembly includes a stroke drive electric cylinder arranged on the other side of the drive seat via a mounting base; the output end of the stroke drive electric cylinder is provided with a synchronization seat; the synchronization seat is rotatably connected to the primary drive center shaft via a bearing.
[0017] Preferably, the micro-distance adjustment assembly includes a micro-distance adjustment bearing seat rotatably arranged on the drive seat; a drive screw is rotatably disposed on the micro-distance adjustment bearing seat; a screw thread sleeve is disposed at the bottom of the drive screw, and the screw thread sleeve is installed and connected to the secondary adjustment connecting seat.
[0018] Preferably, the secondary auxiliary bushing is connected to the primary drive center shaft via a helical cutting seat; wherein the helical cutting seat is a helical structure; wherein the helical cutting seat is a multi-segment frustum shape.
[0019] Preferably, the spiral slitting seat has two working states: in the first working state, the secondary auxiliary bushing is adjusted to be relatively far away from the primary drive center shaft, causing the spiral slitting seat to be in a stretched state, forming a continuous spiral slitting structure; in the second working state, the secondary auxiliary bushing is adjusted to be relatively close to the primary drive center shaft, causing the spiral slitting seat to be in an integral state, forming a single transitional slitting structure.
[0020] Preferably, the switching between the two working states is controlled by the stroke drive electric cylinder's stroke and return drive. During the return drive, the primary drive center shaft pulls the spiral cutting seat to stretch, forming the first working state; during the stroke drive of the stroke drive electric cylinder, the primary drive center shaft pulls the spiral cutting seat to contract, forming the second working state.
[0021] A method for using a pathological slide mounting device includes the following steps: S100: Embedding treatment: If continuous embedding is performed: the diseased tissue is eccentrically embedded in a paraffin block; If a single-layer embedding process is performed: the diseased tissue is eccentrically embedded in a paraffin block; S200, Adjustment Process: If continuous adjustment is performed: the stroke drive electric cylinder is controlled by the stroke return drive. During the return drive, the first-stage drive center shaft pulls the spiral cutting seat to stretch, so that the two ends of the spiral cutting seat move away from each other, causing the spiral-shaped spiral cutting seat to unfold. The second-stage adjustment connecting seat is adjusted to achieve the lifting and lowering accuracy by rotating the drive screw. If a single-layer adjustment is performed: During the stroke drive of the electric cylinder, the first-stage drive center shaft pulls the spiral cutting seat to contract, so that the two ends of the spiral cutting seat will approach each other and cause the spiral surfaces of the spiral cutting seat to fit together to form a whole. S300, Basic Adhesion Positioning: The spiral cutting seat comes into contact with the pathological paraffin block through the downward drive of the forward and backward drive guide rail; S400, Slicing Process: For continuous slicing: the slicing drive motor drives the synchronous pulley via a synchronous belt, which in turn drives the synchronous pulley, bearing seat A, primary drive central shaft, central shaft sleeve A, and secondary auxiliary shaft sleeve to rotate the spiral slicing seat. At the same time, the movable stage pushes the installed pathological paraffin block to contact the spiral slicing seat, thus achieving continuous slicing. For single-layer slicing: the moving table is driven to slide and push step by step by the reciprocating movement of the slicing and scraping guide rail to achieve single-layer slicing; S500, Slide Preparation: Place the slide in the slide preparation chamber, adjust it, and transfer it to the glass slide.
[0022] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention achieves the adaptation and adjustment of the slicing mechanism in the pathological slide patching device by driving the central output unit through a large-span adjustment component. This adjustment enables continuous slicing of paraffin blocks and single-layer slicing. These two different methods are used for initial pathological examinations with mild symptoms, effectively and efficiently slicing the pathological slides to address the scattered lesions and limited detection areas, thus improving the efficiency of slide patching during the testing process. Furthermore, another method enables conventional single-layer slicing, facilitating screening and meeting the needs of observing local lesion deterioration in patients with existing disease. The combination of these two different slicing methods effectively improves the overall functionality of the pathological slide patching device.
[0023] 2. In this invention, the inner walls of the central bushing A and the secondary auxiliary bushing are respectively provided with matching key teeth A and key teeth B, which effectively maintains the power output of the primary drive central shaft, avoids the situation where the slicing mechanism in the pathological slide mounting device does not work synchronously, and reduces the situation where the thickness of the pathological paraffin block is too high.
[0024] 3. This invention uses the stroke-driven electric cylinder's stroke return motion to synchronously drive the synchronous seat, which in turn drives the primary drive center shaft to slide. This configuration enables the switching between two different adjustment methods.
[0025] 4. The present invention uses a multi-segment frustum-shaped spiral slitting seat to form an included angle α and at least one included angle β. The relatively small included angle α results in a good slitting angle when the spiral slitting seat is in the fitted state, which facilitates the passage of pathological paraffin blocks for slitting. The relatively large included angle β results in a longer axial distance when the spiral slitting seat is unfolded, which is adapted to the limitation of radial size. In the good spiral slitting state, it effectively provides sufficient space for spiral pathological sections to pass through.
[0026] 5. This invention utilizes the stroke-driven electric cylinder's stroke-driven return-stroke control. During the return stroke, the primary drive center shaft pulls the spiral slicing seat to stretch, causing the two ends of the spiral slicing seat to move away from each other, thus unfolding the spiral-shaped slicing seat. The movable stage then pushes the mounted paraffin block to contact the spiral slicing seat, achieving continuous slicing. During the stroke drive, the primary drive center shaft pulls the spiral slicing seat to contract, causing the two ends of the spiral slicing seat to approach each other and form a single unit. The reciprocating movement of the slicing and scraping guide rail then forms a single-layer slicing. Attached Figure Description
[0027] Figure 1 This is a schematic diagram of the overall three-dimensional structure of the present invention; Figure 2 This is a bottom-view three-dimensional structural diagram of the present invention; Figure 3 This is a three-dimensional structural diagram of the slitting system of the present invention; Figure 4 This is a schematic diagram of the split three-dimensional structure of the slitting system of the present invention; Figure 5 This is a three-dimensional structural diagram of the drive unit and micro-adjustment component of the present invention; Figure 6 This is a three-dimensional cross-sectional view of the central output unit of the present invention; Figure 7 This is a schematic diagram showing the centered position of a single-layer embedded pathological tissue. Figure 8 This is a schematic diagram showing the off-center position of continuously embedded pathological tissue. Figure 9 This is a schematic diagram of the multi-segment frustum structure of the spiral cutting seat of the present invention (with included angles a and b marked).
[0028] Explanation of the labels in the diagram: 1. Pathological slide mounting unit; 2. Lateral drive rail; 3. Forward and backward drive rail; 4. Slicing system; 5. Movable stage; 6. Slicing and scraping guide rail; 7. Drive seat; 8. Central output unit; 9. Drive unit; 10. Large span adjustment component; 11. Micro-distance adjustment component; 12. Bearing seat A; 13. Spiral slicing seat; 801, Central sleeve A; 8011, Key tooth A; 802, Sliding shaft; 803, Secondary adjustment connecting seat; 804, Secondary auxiliary sleeve; 8041, Key tooth B; 805, Primary drive central shaft; 901. Sliding drive motor; 9011. Drive synchronous pulley; 902. Driven synchronous pulley; 1001. Stroke-driven electric cylinder; 1002. Synchronizer mount; 1101. Micro-adjustment bearing housing; 1102. Drive screw; 1103. Screw sleeve; 15. Paraffin body clamp; 16. Paraffin layer; 17. Pathological tissue. Detailed Implementation
[0029] like Figures 1 to 7 As shown, the present invention relates to a pathological slide mounting device, comprising a pathological slide mounting body 1; the internal gap of the pathological slide mounting body 1 forms an adjustment operation cavity and a slide mounting cavity; a transverse drive rail 2 is provided at the upper end of the slide mounting cavity; a forward and backward drive rail 3 is provided at the movable end of the transverse drive rail 2; a slitting system 4 is provided at the movable end of the forward and backward drive rail 3; a movable stage 5 for mounting pathological paraffin blocks is provided below the slitting system 4; the movable stage 5 is mounted and connected to the pathological paraffin blocks via a mounting base; and the movable stage 5 is mounted and connected to the pathological slide mounting body 1 via a slitting and scraping guide rail 6; a slide mounting compartment is provided inside the pathological slide mounting body 1 relative to the bottom of the slide mounting cavity; the slitting system 4 includes a drive seat 7 arranged at the movable end of the forward and backward drive rail 3; a central output unit 8, a drive unit 9, a large span adjustment component 10, and a micro-adjustment component 11 are respectively provided on the drive seat 7. This invention achieves the adaptation and adjustment of the slicing mechanism in the pathological slide mounting device by driving the central output unit 8 through the large-span adjustment component 10. This adjustment enables continuous slicing of the paraffin block and single-layer slicing. These two different methods are used for initial pathological examinations with mild symptoms, effectively and efficiently slicing the pathological slides to address the scattered lesions and limited detection areas, thus improving the efficiency of slide mounting during the testing process. Furthermore, another method enables conventional single-layer slicing, facilitating screening and meeting the needs of observing local lesion deterioration in patients with existing disease. The combination of these two different slicing methods effectively improves the overall functionality of the pathological slide mounting device.
[0030] In an embodiment of the present invention, the central output unit 8 includes a central bushing A801 arranged on the drive seat 7 via a bearing seat A12; the inner wall of the central bushing A801 is provided with key teeth A8011; a secondary adjustment connecting seat 803 is provided below the central bushing A801 via a directional sliding shaft 802; a secondary auxiliary bushing 804 is provided at the same axial position relative to the central bushing A801 on the secondary adjustment connecting seat 803; wherein the inner surface of the secondary auxiliary bushing 804 is provided with key teeth B8041; wherein the axial inner diameter gap between the central bushing A801 and the secondary auxiliary bushing 804 forms a sliding adjustment cavity; and a primary drive central shaft 805 is keyed inside the sliding adjustment cavity. In this invention, the inner walls of the central bushing A801 and the secondary auxiliary bushing 804 are respectively provided with matching key teeth A8011 and key teeth B8041, which effectively maintains the power output of the primary drive central shaft 805, avoids the situation where the slicing mechanism in the pathological slide mounting device does not work synchronously, and reduces the situation where the thickness of the pathological paraffin block is too high.
[0031] In an embodiment of the present invention, the drive unit 9 includes a slitting drive motor 901 arranged on one side of the drive seat 7; the output end of the slitting drive motor 901 is provided with a drive synchronous pulley 9011; wherein, the drive unit 9 also includes a driven synchronous pulley 902 fixed to the top of the bearing seat A12; wherein, the primary drive central shaft 805, the central shaft sleeve A801, and the secondary auxiliary shaft sleeve 804 are all connected to the slitting drive motor 901 through the bearing seat A12, the drive synchronous pulley 9011, the synchronous belt, and the drive synchronous pulley 9011.
[0032] In an embodiment of the present invention, the large-span adjustment assembly 10 includes a stroke drive electric cylinder 1001 arranged on the other side of the drive base 7 via a mounting base; a synchronization seat 1002 is provided at the output end of the stroke drive electric cylinder 1001; the synchronization seat 1002 is rotatably connected to the primary drive central shaft 805 via a bearing. The present invention uses the stroke drive electric cylinder 1001's stroke return motion to synchronously drive the synchronization seat 1002, thereby driving the primary drive central shaft 805 to slide. This arrangement enables two different adjustment switching operations.
[0033] In an embodiment of the present invention, the micro-adjustment assembly 11 includes a micro-adjustment bearing seat 1101 rotatably arranged on a drive seat 7; a drive screw 1102 is rotatably disposed on the micro-adjustment bearing seat 1101; a screw thread sleeve 1103 is disposed at the bottom of the drive screw 1102, and the screw thread sleeve 1103 is installed and connected to the secondary adjustment connecting seat 803. The present invention achieves the lifting and lowering of the secondary adjustment connecting seat 803 by rotating the drive screw 1102, thereby precisely adjusting the spiral distance of the slicing mechanism in the pathological slide mounting device, so as to accurately control the slicing thickness of the paraffin block during the rotary cutting process.
[0034] In an embodiment of the present invention, the secondary auxiliary bushing 804 is connected to the primary drive central shaft 805 via a helical cutting seat 13; wherein, the helical cutting seat 13 has a helical structure; wherein, the helical cutting seat 13 is a multi-segment frustum shape. Figure 9 The present invention shows that the spiral slicing seat 13 is arranged in a multi-segment frustum shape, forming an included angle α and at least one included angle β. With the included angle α being relatively small, the spiral slicing seat 13 has a good slicing included angle in the attached state, which facilitates the passage of pathological paraffin blocks for slicing. With the included angle β being relatively large, the spiral slicing seat 13 has a longer axial distance in the unfolded state, which is adapted to the limitation of radial size. In the state of good spiral slicing, it effectively provides sufficient space for spiral pathological sections to pass through.
[0035] In embodiments of the present invention, the spiral slicing seat 13 has two working states: In the first working state, the secondary auxiliary bushing 804 and the primary drive central shaft 805 are adjusted to be relatively far apart, causing the spiral slicing seat 13 to be in a stretched state, forming a continuous spiral slicing structure; the present invention controls the stroke and return stroke of the stroke drive electric cylinder 1001. During the return stroke, the primary drive central shaft 805 pulls the spiral slicing seat 13 to be stretched, so that the two ends of the spiral slicing seat 13 move relatively far apart, causing the spiral-shaped spiral slicing seat 13 to unfold, and the movable table 5 pushes the installed pathological paraffin block to contact the spiral slicing seat 13, realizing continuous slicing work; In the second working state, the secondary auxiliary bushing 804 and the primary drive central shaft 805 are adjusted to be relatively close, causing the spiral slicing seat 13 to be in an integrated state, forming a single transitional slicing structure. In this invention, the first-stage drive center shaft 805 pulls the spiral slitting seat 13 to retract during the stroke drive of the stroke drive electric cylinder 1001, so that the two ends of the spiral slitting seat 13 will approach each other and the spiral surfaces of the spiral slitting seat 13 will fit together to form a whole, and the single-layer slicing work is formed by the reciprocating movement of the slitting and scraping guide rail 6.
[0036] In an embodiment of the present invention, the switching between the two working states is controlled by the stroke drive electric cylinder 1001 during the stroke drive. During the return drive, the primary drive center shaft 805 pulls the spiral cutting seat 13 to stretch, forming the first working state; during the stroke drive, the primary drive center shaft 805 pulls the spiral cutting seat 13 to contract, forming the second working state.
[0037] Working principle: This embodiment provides a method for using a pathological slide mounting device. The steps are as follows: S100: Embedding treatment: If continuous embedding is performed: the diseased tissue is eccentrically embedded in a paraffin block, such as... Figure 8 As shown; If a single-layer embedding process is performed: the diseased tissue is eccentrically embedded in a paraffin block, such as... Figure 7 As shown; S200, Adjustment Process: If continuous adjustment is performed: the stroke drive cylinder 1001 controls the stroke return drive. During the return drive, the first-stage drive center shaft 805 pulls the spiral cutting seat 13 to stretch, so that the two ends of the spiral cutting seat 13 move away from each other, causing the spiral-shaped spiral cutting seat 13 to unfold. The second-stage adjustment connecting seat 803 is adjusted in terms of lifting and lowering accuracy by rotating the drive screw 1102. If a single-layer adjustment is performed: During the stroke drive of the electric cylinder 1001, the first-stage drive center shaft 805 pulls the spiral cutting seat 13 to contract, so that the two ends of the spiral cutting seat 13 will approach each other and cause the spiral surfaces of the spiral cutting seat 13 to fit together to form a whole. S300, Basic Adhesion Positioning: The spiral cutting seat 13 comes into contact with the pathological paraffin block through the downward drive of the forward and backward drive guide rail 3; S400, Slicing Process: For continuous slicing: the slicing drive motor 901 drives the drive synchronous wheel 9011, which in turn drives the synchronous belt, bearing seat A12, primary drive central shaft 805, central shaft sleeve A801, and secondary auxiliary shaft sleeve 804 to rotate the spiral slicing seat 13. At the same time, the movable stage 5 pushes the installed pathological paraffin block to contact the spiral slicing seat 13, thus realizing continuous slicing work. If a single-layer slicing process is to be performed: the moving stage 5 is driven to slide and be pushed step by step by the reciprocating movement of the slicing and scraping guide rail 6 to achieve single-layer slicing work; S500, Slide Preparation: Place the slide in the slide preparation chamber, adjust it, and transfer it to the glass slide.
[0038] The embodiments disclosed in this invention are preferred embodiments, but are not limited thereto. Those skilled in the art can easily understand the spirit of this invention based on the above embodiments and make different extensions and variations, but as long as they do not depart from the spirit of this invention, they are all within the protection scope of this invention.
Claims
1. A pathological slide mounting device, characterized in that, The system includes a pathological slide patch assembly body (1); the internal gaps of the pathological slide patch assembly body (1) form an adjustment operation cavity and a slide patch assembly cavity; The upper end of the cavity of the slice patch is provided with a transverse drive rail (2); the movable end of the transverse drive rail (2) is provided with an advance and retreat drive rail (3); the movable end of the advance and retreat drive rail (3) is provided with a slitting system (4). Below the slitting system (4) is a movable platform (5) for mounting pathological paraffin blocks; the movable platform (5) is connected to the pathological paraffin blocks via a mounting base; and the movable platform (5) is connected to the pathological slide mounting body (1) via a slitting and scraping guide rail (6). The pathological slide patch assembly body (1) is provided with a patch assembly compartment at the bottom of the slide patch assembly cavity; The slitting system (4) includes a drive seat (7) arranged at the movable end of the forward and backward drive guide rail (3); the drive seat (7) is respectively provided with a center output unit (8), a drive unit (9), a large span adjustment component (10), and a micro-distance adjustment component (11).
2. The pathological slide mounting device according to claim 1, characterized in that, The central output unit (8) includes a central bushing A (801) arranged on the drive seat (7) via a bearing seat A (12); the inner wall of the central bushing A (801) is provided with key teeth A (8011); A secondary adjustment connecting seat (803) is provided below the central bushing A (801) via a directional sliding shaft (802); The secondary adjustment connecting seat (803) is provided with a secondary auxiliary bushing (804) at the same axial position relative to the central bushing A (801); wherein, the inner surface of the secondary auxiliary bushing (804) is provided with key teeth B (8041). The axial inner diameter gap between the central bushing A (801) and the secondary auxiliary bushing (804) forms a sliding adjustment cavity; and a primary drive central shaft (805) is keyed inside the sliding adjustment cavity.
3. The pathological slide mounting device according to claim 2, characterized in that, The drive unit (9) includes a slitting drive motor (901) arranged on one side of the drive seat (7); the output end of the slitting drive motor (901) is provided with a drive synchronous pulley (9011). The drive unit (9) also includes a driven synchronous wheel (902) fixed to the top of the bearing seat A (12). The primary drive center shaft (805), the center shaft sleeve A (801), and the secondary auxiliary shaft sleeve (804) are all connected to the cutting drive motor (901) via bearing seat A (12), drive synchronous pulley (9011), synchronous belt, and drive synchronous pulley (9011).
4. The pathological slide mounting device according to claim 3, characterized in that, The large span adjustment assembly (10) includes a stroke drive electric cylinder (1001) arranged on the other side of the drive seat (7) via a mounting base; the output end of the stroke drive electric cylinder (1001) is provided with a synchronizing seat (1002); the synchronizing seat (1002) is rotatably connected to the primary drive center shaft (805) via a bearing.
5. The pathological slide mounting device according to claim 4, characterized in that, The micro-adjustment assembly (11) includes a micro-adjustment bearing seat (1101) rotatably arranged on the drive seat (7); a drive screw (1102) is rotatably arranged on the micro-adjustment bearing seat (1101); a screw thread sleeve (1103) is provided at the bottom of the drive screw (1102), and the screw thread sleeve (1103) is installed and connected to the secondary adjustment connecting seat (803).
6. The pathological slide mounting device according to claim 5, characterized in that, The secondary auxiliary bushing (804) is connected to the primary drive center shaft (805) via a helical cutting seat (13); The spiral cutting seat (13) is a spiral structure. The spiral cutting seat (13) is a multi-segment frustum shape.
7. The pathological slide mounting device according to claim 6, characterized in that, The spiral cutting seat (13) has two working states: In the first working state, the secondary auxiliary bushing (804) and the primary drive center shaft (805) are adjusted to be relatively far apart, causing the spiral cutting seat (13) to be in a stretched state, forming a continuous spiral cutting structure; In the second working state, the secondary auxiliary bushing (804) and the primary drive center shaft (805) are adjusted to be relatively close to each other, so that the spiral cutting seat (13) is integrated into one unit, forming a single transition cutting structure.
8. The pathological slide mounting device according to claim 7, characterized in that, The switching between the two working states is controlled by the stroke drive electric cylinder (1001) during the stroke drive. During the return drive, the primary drive center shaft (805) pulls the spiral cutting seat (13) to stretch, forming the first working state; during the stroke drive of the stroke drive electric cylinder (1001), the primary drive center shaft (805) pulls the spiral cutting seat (13) to contract, forming the second working state.
9. A method of using a pathological slide mounting device, applicable to the pathological slide mounting device as described in claim 8, characterized in that, Includes the following steps: S100: Embedding treatment: If continuous embedding is performed: the diseased tissue is eccentrically embedded in a paraffin block; If a single-layer embedding process is performed: the diseased tissue is eccentrically embedded in a paraffin block; S200, Adjustment Process: If continuous adjustment is performed: the stroke drive cylinder (1001) controls the stroke return drive. During the return drive, the first-stage drive center shaft (805) pulls the spiral cutting seat (13) to stretch, so that the two ends of the spiral cutting seat (13) move away from each other, causing the spiral-shaped spiral cutting seat (13) to unfold. The second-stage adjustment connecting seat (803) is adjusted to improve the lifting and lowering accuracy by rotating the drive screw (1102). If a single-layer adjustment is performed: During the stroke drive of the electric cylinder (1001), the first-stage drive center shaft (805) pulls the spiral cutting seat (13) to contract, so that the two ends of the spiral cutting seat (13) will approach each other and cause the spiral surfaces of the spiral cutting seat (13) to fit together to form a whole. S300, Basic Adhesion Positioning: The spiral cutting seat (13) is brought into contact with the pathological paraffin block by the downward drive of the forward and backward drive guide rail (3); S400, Slicing Process: If continuous slicing is performed: the slicing drive motor (901) drives the drive synchronous wheel (9011) via the synchronous belt, the synchronous wheel (9011), the bearing seat A (12), the first-stage drive center shaft (805), the center shaft sleeve A (801), and the second-stage auxiliary shaft sleeve (804) to drive the spiral slicing seat (13) to rotate. At the same time, the movable table (5) pushes the installed pathological paraffin block to contact the spiral slicing seat (13) to achieve continuous slicing work. If a single-layer slicing process is to be performed: the moving stage (5) is driven to slide and be pushed step by step by the reciprocating movement of the slicing and scraping guide rail (6) to achieve single-layer slicing work; S500, Slide Preparation: Place the slide in the slide preparation chamber, adjust it, and transfer it to the glass slide.