Traditional Chinese medicine compound composition for treating psoriasis and application thereof

Abstract

The invention provides a traditional Chinese medicine compound composition for treating psoriasis and application of the traditional Chinese medicine compound composition, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine compound composition for treating psoriasis is prepared from the following raw materials: radix isatidis, radix sophorae flavescentis, radix scutellariae, radix salviae miltiorrhizae, radix angelicae sinensis and radix et rhizoma rhei, the traditional Chinese medicine theory is combined, and the traditional Chinese medicine raw materials synergistically exert effects, so that the effects of inhibiting inflammatory response, inhibiting keratinocyte proliferation and inducing keratinocyte apoptosis are achieved; the skin lesion symptom of the psoriasis can be obviously improved, and the traditional Chinese medicine compound composition disclosed by the invention has an obvious curative effect on the psoriasis.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, and particularly relates to a traditional Chinese medicine compound composition for treating psoriasis and its application. Background Technology

[0002] Psoriasis is an immune-mediated chronic inflammatory skin disease. Domestic and international surveys on the incidence of psoriasis show that its prevalence in the general population is 0.1%-0.3%, and with industrialization, urbanization, and increased work pressure, the incidence of psoriasis is gradually increasing, and it has now become one of the key diseases for prevention and treatment in international dermatology.

[0003] Traditional Chinese medicine (TCM) possesses unique advantages and characteristics in the treatment of psoriasis. Through various treatment principles such as clearing heat and detoxifying, cooling blood and moisturizing dryness, dispelling wind and relieving itching, and promoting blood circulation and removing blood stasis, it can effectively alleviate and control symptoms, reduce recurrence, and even achieve a cure. Therefore, this invention proposes a novel TCM compound composition for the treatment of psoriasis and its application. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention proposes a traditional Chinese medicine compound composition for treating psoriasis and its application.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] One of the technical solutions of the present invention:

[0007] A traditional Chinese medicine compound composition for treating psoriasis, comprising the following ingredients:

[0008] Isatis root, Sophora flavescens, Scutellaria baicalensis, Salvia miltiorrhiza, Angelica sinensis, and rhubarb.

[0009] This invention, through the selection of various traditional Chinese medicine raw materials, achieves the therapeutic effects of inhibiting inflammatory responses, suppressing keratinocyte proliferation, and inducing keratinocyte apoptosis by the combined action of these raw materials, thereby treating psoriasis. In the compound traditional Chinese medicine composition of this invention, Isatis root (Banlangen) clears heat and detoxifies, cools the blood and reduces swelling, serving as the principal ingredient. Scutellaria baicalensis (Huangqin) clears heat and dries dampness, while Sophora flavescens (Ku Shen) dries dampness and dispels wind, assisting the principal ingredient in increasing its heat-clearing, detoxifying, and blood-cooling effects, serving as the assistant ingredient. Salvia miltiorrhiza (Danshen) cools the blood, invigorates blood circulation, and replenishes blood, ensuring that cooling the blood does not cause blood stasis and invigorating blood circulation does not deplete yin and blood, serving as the adjuvant ingredient. Rhubarb (Dahuang) breaks up accumulations and promotes blood circulation, serving as the guiding ingredient. Other herbs are added as adjuvants and guides, and the combined effects of these herbs clear heat and detoxify, cool the blood and invigorate blood circulation. All the herbs are cold in nature and enter the blood level, working together to clear heat, cool the blood, and invigorate blood circulation, cooling the blood without causing blood stasis and resolving blood stasis without harming the body's vital energy.

[0010] Furthermore, the preparation method of the traditional Chinese medicine compound composition includes the following steps:

[0011] (1) Add Isatis root, Sophora flavescens, Scutellaria baicalensis, Salvia miltiorrhiza, Angelica sinensis and rhubarb to water for decoction and filtration, collect the filtrate, add water to the residue for a second decoction and filtration, collect the filtrate, combine the filtrates to obtain the medicinal liquid;

[0012] (2) The liquid medicine is concentrated under reduced pressure and freeze-dried to obtain freeze-dried powder particles, which is the traditional Chinese medicine compound composition for treating psoriasis.

[0013] Furthermore, the decoction temperature is 98°C and the extraction time is 0.5 hours.

[0014] Furthermore, the temperature for the vacuum concentration is 65°C.

[0015] The second technical solution of the present invention:

[0016] The use of the aforementioned traditional Chinese medicine compound composition in the preparation of a medicament for treating psoriasis.

[0017] Furthermore, the dosage form of the drug is granules.

[0018] Furthermore, the method for preparing the drug for treating psoriasis includes the following steps:

[0019] (1) The traditional Chinese medicine compound composition is subjected to water extraction and alcohol precipitation, the filtrate is recovered and concentrated to obtain a thick paste;

[0020] (2) The thick paste was dried using vacuum drying technology to obtain a dry extract; the dry extract was pulverized into a fine powder and then lactose, dextrin, protein sugar and PVP (polyvinylpyrrolidone) solution were added to obtain a mixture;

[0021] (3) The mixture is granulated by one-step granulation, and then dried, sized and packaged to obtain the drug for treating psoriasis.

[0022] Furthermore, the relative density of the paste is 1:1.25-1.30.

[0023] Furthermore, the concentration temperature is 50-60°C.

[0024] Furthermore, the mass concentration of the PVP solution is 5%.

[0025] Compared with the prior art, the present invention has the following advantages and technical effects:

[0026] This invention combines traditional Chinese medicine theory, with each Chinese herbal ingredient working synergistically to inhibit inflammatory responses, suppress keratinocyte proliferation, and induce keratinocyte apoptosis, thereby significantly improving the symptoms of psoriasis lesions. The Chinese herbal compound composition of this invention has significant therapeutic effects on psoriasis. Attached Figure Description

[0027] The accompanying drawings, which form part of this invention, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention. In the drawings:

[0028] Figure 1 Photographs of skin lesions in different groups of mice (A) and HE staining results (B). Detailed Implementation

[0029] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0030] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Every smaller range between any stated value or intermediate value within a stated range, and any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0031] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0032] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0033] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0034] This invention provides a traditional Chinese medicine compound composition for treating psoriasis, comprising the following ingredients:

[0035] Isatis root, Sophora flavescens, Scutellaria baicalensis, Salvia miltiorrhiza, Angelica sinensis, and rhubarb.

[0036] This invention combines traditional Chinese medicine theory, selecting various Chinese medicinal materials with properties such as clearing heat and detoxifying, cooling blood and reducing swelling. Through the combined effects of these materials, the symptoms of psoriasis lesions can be significantly improved, demonstrating a significant therapeutic effect on psoriasis. In a preferred embodiment of this invention, the raw materials of the compound Chinese medicine composition can be mixed in any proportion.

[0037] In a preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine compound composition includes the following steps:

[0038] (1) Add Isatis root, Sophora flavescens, Scutellaria baicalensis, Salvia miltiorrhiza, Angelica sinensis and rhubarb to water for decoction and filtration, collect the filtrate, add water to the residue for a second decoction and filtration, collect the filtrate, combine the filtrates to obtain the medicinal liquid;

[0039] (2) The drug solution is concentrated under reduced pressure and freeze-dried to obtain freeze-dried powder granules, which are Chinese medicine compound compositions used to treat psoriasis.

[0040] In a preferred embodiment of the present invention, the decoction temperature is 98°C and the extraction time is 0.5 h.

[0041] In a preferred embodiment of the present invention, the temperature for vacuum concentration is 65°C.

[0042] This invention also proposes the application of a traditional Chinese medicine compound composition in the preparation of a drug for treating psoriasis.

[0043] In a preferred embodiment of the present invention, the dosage form of the drug is granules.

[0044] In a preferred embodiment of the present invention, the method for preparing a medicament for treating psoriasis includes the following steps:

[0045] (1) After water extraction and alcohol precipitation, the compound Chinese medicine composition is recovered and concentrated to obtain a thick paste.

[0046] (2) The thick paste was dried using vacuum drying technology to obtain a dry extract; the dry extract was pulverized into a fine powder and then lactose, dextrin, protein sugar and PVP (polyvinylpyrrolidone) solution were added to obtain a mixture;

[0047] (3) The mixture is granulated by one-step granulation, and then dried, granulated and packaged to obtain a drug for treating psoriasis.

[0048] In a preferred embodiment of the present invention, the relative density of the paste is 1:1.25-1.30.

[0049] In a preferred embodiment of the present invention, the concentration temperature is 50-60°C.

[0050] In a preferred embodiment of the present invention, the mass concentration of the PVP solution is 5%.

[0051] The technical solution of the present invention will be further illustrated by the following embodiments.

[0052] Example 1

[0053] A method for preparing a traditional Chinese medicine compound composition includes the following steps:

[0054] (1) Add 30 parts by weight of Isatis root, 9 parts by weight of Sophora flavescens, 9 parts by weight of Scutellaria baicalensis, 9 parts by weight of Salvia miltiorrhiza, 9 parts by weight of Angelica sinensis and 6 parts by weight of rhubarb to 5 times the amount of water for decoction and filtration. Collect the filtrate, add 3 times the amount of water to the residue for a second decoction and filtration, collect the filtrate, and combine the filtrates to obtain the medicinal liquid; wherein, the decoction temperature is 98℃ and the extraction time is 0.5h;

[0055] (2) The medicinal liquid is concentrated under reduced pressure at 65°C and freeze-dried to obtain freeze-dried powder granules, which are the traditional Chinese medicine compound composition used to treat psoriasis.

[0056] Application Example 1

[0057] The traditional Chinese medicine compound composition prepared in Example 1 is further prepared into a granule form for the treatment of psoriasis, including the following steps:

[0058] (1) The traditional Chinese medicine compound composition prepared in Example 1 was subjected to water extraction and alcohol precipitation. The filtrate was recovered and concentrated at 50-60℃ to obtain a thick paste with a relative density of 1:1.25-1.30.

[0059] (2) The thick paste was dried using vacuum drying technology to obtain a dry extract; the dry extract was pulverized into a fine powder, and lactose, dextrin, protein sugar and a 5% PVP solution were added to obtain a mixture;

[0060] (3) The mixture is granulated by one-step granulation method, and after drying, granulation and packaging, each bag contains 4g to obtain the drug for treating psoriasis.

[0061] Performance testing

[0062] Photographs of skin lesions in different groups of mice (A) and HE staining results (B) are shown below. Figure 1In the figures, CON represents the blank control group (mice received no treatment), IMQ represents the imiquimod-induced psoriasis-like skin inflammation animal model group, and XYKL-LD and XYKL-HD represent the low-dose and high-dose groups of the drug prepared in Example 1 for treating psoriasis, respectively, in the imiquimod-induced psoriasis-like skin inflammation mouse model. Acitretin represents the group treated with acitretin (vitamin A acid) in the imiquimod-induced psoriasis-like skin inflammation mouse model. It can be seen that the drug prepared in Example 1 for treating psoriasis can significantly alleviate the imiquimod-induced psoriasis mouse model, and the therapeutic effect is basically consistent with that of the positive control drug, vitamin A acid. Therefore, the drug prepared in this invention can better treat psoriasis and has a significant effect.

[0063] The above are merely preferred embodiments of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A traditional Chinese medicine compound composition for treating psoriasis, characterized in that, Including the following raw materials: Isatis root, Sophora flavescens, Scutellaria baicalensis, Salvia miltiorrhiza, Angelica sinensis, and rhubarb.

2. The traditional Chinese medicine compound composition for treating psoriasis according to claim 1, characterized in that, The preparation method of the traditional Chinese medicine compound composition includes the following steps: (1) Add Isatis root, Sophora flavescens, Scutellaria baicalensis, Salvia miltiorrhiza, Angelica sinensis and rhubarb to water for decoction and filtration, collect the filtrate, add water to the residue for a second decoction and filtration, collect the filtrate, combine the filtrates to obtain the medicinal liquid; (2) The liquid medicine is concentrated under reduced pressure and freeze-dried to obtain freeze-dried powder particles, which is the traditional Chinese medicine compound composition for treating psoriasis.

3. The traditional Chinese medicine compound composition for treating psoriasis according to claim 2, characterized in that, The decoction temperature was 98℃, and the extraction time was 0.5h.

4. The traditional Chinese medicine compound composition for treating psoriasis according to claim 2, characterized in that, The vacuum concentration temperature is 65°C.

5. The use of the traditional Chinese medicine compound composition according to any one of claims 1-4 in the preparation of a medicament for treating psoriasis.

6. The use of the traditional Chinese medicine compound composition according to claim 5 in the preparation of a medicament for treating psoriasis, characterized in that, The drug is in granule form.

7. The use of the traditional Chinese medicine compound composition according to claim 5 in the preparation of a medicament for treating psoriasis, characterized in that, The method for preparing the drug for treating psoriasis includes the following steps: (1) The traditional Chinese medicine compound composition is subjected to water extraction and alcohol precipitation, the filtrate is recovered and concentrated to obtain a thick paste; (2) The thick paste was dried using vacuum drying technology to obtain a dry extract; the dry extract was pulverized into a fine powder, and lactose, dextrin, protein sugar and PVP solution were added to obtain a mixture; (3) The mixture is granulated by one-step granulation, and then dried, sized and packaged to obtain the drug for treating psoriasis.

8. The use of the traditional Chinese medicine compound composition according to claim 7 in the preparation of a medicament for treating psoriasis, characterized in that, The relative density of the paste is 1:1.25-1.

30.

9. The use of the traditional Chinese medicine compound composition according to claim 7 in the preparation of a medicament for treating psoriasis, characterized in that, The concentration temperature is 50-60℃.

10. The use of the traditional Chinese medicine compound composition according to claim 7 in the preparation of a medicament for treating psoriasis, characterized in that, The mass concentration of the PVP solution is 5%.

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