Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating sleep disorder caused by new coronavirus infection and preparation method of traditional Chinese medicine preparation

Abstract

The invention discloses a traditional Chinese medicine composition and a traditional Chinese medicine preparation for treating sleep disorder caused by new coronavirus infection and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. Aiming at the problems that no medicine with definite curative effect exists for sleep disorder of a new coronavirus infected patient at present, and the medicine can only depend on the individual immunity of the patient to resist, the traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight: 10g of radix pseudostellariae, 12g of radix paeoniae rubra, 10g of radix salviae miltiorrhizae, 6g of rhodiola rosea, 6g of exocarpium citri grandis, 5g of ginger processed pinellia, 15g of poria cocos, 15g of poria with hostwood, 15g of herba patriniae, 15g of tuber fleeceflower stem, 12g of hairyvein agrimony, 6g of liquorice, 10g of chrysanthemum and 6g of cassia twig. The traditional Chinese medicine composition is based on the principles of tonifying qi and activating blood, reducing phlegm and dredging collaterals, and clearing pestilence and soothing nerves, all the medicines are synergistic and supplement one another, the blood oxygen concentration and the red blood cell oxygen carrying capacity of a human body are improved, the blood viscosity is reduced, microcirculation is promoted, residual toxins are eliminated, and patients are helped to recover high-quality sleep.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating sleep disorders caused by new coronavirus infection, a traditional Chinese medicine preparation and a preparation method thereof. BACKGROUND

[0002] COVID-19 is an acute and infectious disease caused by the pathogen of a new coronavirus (SARS-CoV-2). The cytokine storm (CS) caused by such viruses is an important cause of death in patients infected with COVID-19. The main clinical manifestations are elevated body temperature, cough, dyspnea, fatigue and the like. Some severe patients can cause acute respiratory distress syndrome (ARDS) and other serious complications. The incubation period is 1-14 days. Dyspnea, i.e. nasal incoordination, can hinder the flow of defensive qi from yang to yin, thereby causing the unrest of primordial spirit, resulting in imbalance of clear and turbid, non-interaction of heart and kidney, and further causing insomnia. COVID-19 is a highly infectious disease, which often causes sleep disorders. Studies have shown that the incidence of sleep disorders in adults infected with COVID-19 is 56.67%, and the probability of sleep disorders in COVID-19 infected patients is significantly higher than that in normal people. Studies have also shown that COVID-19 interacts with angiotensin-converting enzyme (ACE2) in human blood, causing infection of the respiratory system. A large number of ACE2 exist on the cell membrane of brain neurons, indicating that the new coronavirus is likely to have the ability to invade the nervous system. The case observation results of the New Coronavirus Diagnosis and Treatment Plan (Trial Version 7) show that some neurons in the brain tissue of COVID-19 infected patients degenerate, indicating that the reason for sleep disorders in COVID-19 patients may be the invasion of the new coronavirus on the brain nerves. In addition, the use of central excitatory drugs in clinical practice is also an important cause of sleep disorders after infection.

[0003] Some antiviral drugs and traditional Chinese medicines have been used in clinical treatment of this new coronavirus infection disease, but the curative effect is not exact.

[0004] The new coronavirus infection disease belongs to the category of epidemic diseases in traditional Chinese medicine, and the cause is to be affected by the 'epidemic evil' qi. It can also be said to be affected by the lung wind. The epidemic disease is divided into cold epidemic, warm epidemic (pestilence), and mixed epidemic in traditional Chinese medicine, and the warm epidemic can be divided into hot and dry epidemic, wet heat epidemic and wet toxic epidemic. Different schools of traditional Chinese medicine have different understandings of the etiology of new coronavirus infection. Academician Geng Xiaolin believes that COVID-19 is caused by cold and dampness, Li Xiuyuan believes that COVID-19 belongs to wet toxic epidemic, and Zhou Yongxue believes that COVID-19 is a wet heat epidemic. Combined with the geographical characteristics and clinical manifestations of the current epidemic, most experts recognize the view of wet toxic epidemic. Insomnia can be classified as 'insomnia' in traditional Chinese medicine, which seriously affects human physical and mental health. Traditional Chinese medicine believes that the overall pathogenesis of insomnia is the imbalance of Wei and Ying, and the imbalance of Qi and blood, resulting in the imbalance of Yin and Yang of five Zang organs, and the deficiency of Shen. The Wei-Qi-Ying-blood syndrome of 'warm disease' was created by Ye Tianshi. After COVID-19 infection, many people have insomnia, and the evolution process of its pathogenesis is divided into four stages: evil entering Wei, evil entering Qi, evil entering Ying, and evil entering blood. The course of the disease is gradually deepened, and individual differences often need to be checked for pathogenesis and treated according to syndrome differentiation.

[0005] In view of the current deficiency of COVID-19 treatment, combined with the unique advantages of traditional Chinese medicine, the development of traditional Chinese medicine with exact curative effect and low toxicity for treating the virus is of great significance for the clinical treatment of sleep disorders caused by viral infection. SUMMARY

[0006] In order to quickly and effectively curb the threat of new coronavirus infection disease to human life and health, and solve the current treatment blank of western medicine for this disease, and rely on the regulation of human collective immune function, the purpose of the present application is to provide a traditional Chinese medicine composition for treating sleep disorders caused by new coronavirus infection, a traditional Chinese medicine preparation and a preparation method thereof, so as to effectively solve the problems existing in the background art.

[0007] In order to achieve the above technical purpose, the following technical scheme is adopted in the present application: The first aspect of the technical scheme disclosed by the present application is a traditional Chinese medicine composition for treating sleep disorders caused by new coronavirus infection, which comprises the following weight parts of traditional Chinese medicinal materials: 6-15g of Taizishen, 6-15g of Chishao, 6-15g of Danshen, 3-9g of Hongjingtian, 3-9g of Huazao, 3-9g of Jiangbanxia, 10-20g of Fuling, 10-20g of Fushen, 9-20g of Baijiangcao, 9-20g of Yijiaoteng, 6-15g of Xianhecao, 2-10g of Gancao, 5-15g of Juhe, and 3-10g of Guizhi.

[0008] As a further preferred embodiment of the above technical solution: the traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight: Codonopsis pilosula 8-12g, Paeonia lactiflora 8-12g, Salvia miltiorrhiza 10-12g, Rhodiola rosea 4-6g, Citrus reticulata 4-6g, Pinellia ternata 3-6g, Poria cocos 12-15g, Poria cocos sclerotium 12-15g, Patrinia scabiosaefolia 12-15g, Polygonum multiflorum 12-15g, Agrimonia pilosa 8-12g, Glycyrrhiza uralensis 4-8g, Chrysanthemum morifolium 8-10g, and Cinnamomum cassia 5-8g.

[0009] As a further preferred embodiment of the above technical solution: the traditional Chinese medicine composition includes the following traditional Chinese medicinal materials in parts by weight: Codonopsis pilosula 10g, Paeonia lactiflora 12g, Salvia miltiorrhiza 10g, Rhodiola rosea 6g, Citrus reticulata 6g, Pinellia ternata 5g, Poria cocos 15g, Poria cocos sclerotium 15g, Patrinia scabiosaefolia 15g, Polygonum multiflorum 15g, Agrimonia pilosa 12g, Glycyrrhiza uralensis 6g, Chrysanthemum morifolium 10g, and Cinnamomum cassia 6g.

[0010] The pharmacological effects of the various Chinese medicinal materials involved in this invention according to the Chinese Pharmacopoeia are as follows: Prince ginseng: also known as child ginseng, is the dried tuberous root of a perennial herbaceous plant of the Caryophyllaceae family. It tastes sweet and slightly bitter, is neutral in nature, and enters the spleen and lung meridians. It has the effects of replenishing qi and nourishing yin, promoting body fluid and quenching thirst. Its pharmacological effects are similar to those of ginseng but weaker.

[0011] Red peony root: The dried root of Paeonia lactiflora Pal. or P. veitchii Lynch, a plant of the Paeoniaceae family. It has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It is mainly used to treat febrile diseases with rashes, hematemesis and epistaxis due to blood heat, red and swollen eyes, carbuncles and sores, hypochondriac pain due to liver stagnation, amenorrhea and dysmenorrhea, abdominal pain due to abdominal masses, and traumatic injuries.

[0012] Danshen: The dried root and rhizome of Salvia miltiorrhiza Bge., a plant of the Lamiaceae family. It has the effects of promoting blood circulation and regulating menstruation, relieving pain, cooling blood and reducing swelling, and calming the mind. It is mainly used to treat irregular menstruation, amenorrhea and dysmenorrhea, postpartum abdominal pain due to blood stasis, heart pain due to blood stasis, abdominal pain, scars, traumatic injuries, rheumatic arthralgia, carbuncles and boils, fever with restlessness and delirium, palpitations and insomnia.

[0013] Rhodiola rosea: The rhizome of Rhodiola rosea Limn. or Rhodiola euryphylla (Frod.) SHFu., belonging to the Crassulaceae family, has the effects of strengthening the spleen and replenishing qi, clearing the lungs and relieving cough, and promoting blood circulation and removing blood stasis. It is mainly used to treat spleen qi deficiency syndrome, lung yin deficiency, and cough due to lung heat.

[0014] Citrus grandis (L.) Osbeck var. tomentosa Hort. (C. grandis Tomentosa) or C. grandis (L.) Osbeck. It has the functions of drying dampness, reducing phlegm, regulating qi and digesting food. It is used to treat wind-cold cough with much phlegm, chest distress, food accumulation and vomiting, and belching.

[0015] Ginger pinellia. It is mainly used to relieve symptoms of cold, cough and phlegm, gastrointestinal discomfort, and antibacterial and anti-inflammatory.

[0016] Poria cocos (Schw.) Wolf. It has the functions of promoting urination, reducing swelling, strengthening the spleen and calming the heart. It is used to treat edema, phlegm, diarrhea, palpitation and insomnia.

[0017] Poria cocos (Schw.) Wolf. It has the functions of promoting urination, reducing swelling, strengthening the spleen and calming the heart. It is used to treat edema, phlegm, diarrhea, palpitation and insomnia.

[0018] Patrinia scabiosaefolia Fisch. ex Link, P. villose Juss. It has the functions of clearing heat and resolving toxins, eliminating carbuncles and pus, and removing blood stasis and relieving pain. It is used to treat intestinal abscess, lung pain, carbuncle and postpartum abdominal pain.

[0019] Fallopia multiflora (Thunb.) Harald. It has the functions of nourishing the heart and relieving insomnia, dispelling wind, and unblocking collaterals. It is used to treat insomnia, dreaminess, blood deficiency and body pain, numbness of the skin, rheumatism and pruritus.

[0020] Agrimonia pilosa Ledb. It has the functions of astringing and stopping bleeding, stopping diarrhea, stopping malaria and tonifying deficiency. It is used to treat various bleeding, chronic diarrhea, chronic dysentery, malaria and deficiency of qi and blood.

[0021] Glycyrrhiza uralensis Fisch. It has the functions of tonifying the spleen and replenishing qi, anti-inflammatory and bactericidal, and enhancing immunity. It can enhance immunity, anti-inflammatory, anti-gastric ulcer, anti-arrhythmia and regulate blood sugar.

[0022] Chrysanthemum: Chrysanthemum morifolium Ramat. The dried inflorescence of Chrysanthemum genus of Asteraceae, has the effects of dispersing wind-heat, suppressing liver yang, clearing liver and eyesight, clearing heat and resolving toxicity; it is used for treating wind-heat cold, warm disease at the beginning, liver yang dizziness, liver wind syndrome, red eyes and blurred vision, sores and carbuncles.

[0023] Cassia twig: the dried tender branches of Cinnamomum cassia, which are cut in spring and summer, dried or dried in the shade, and cut into thin slices or small pieces, has the effects of sweating and relieving the skin, warming the meridians, and assisting Yang and transforming qi.

[0024] The second aspect of the technical scheme disclosed in the present application is a traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection, which is prepared from the above-mentioned traditional Chinese medicine composition.

[0025] Further preferred scheme is that the traditional Chinese medicine preparation is any one of decoction, oral preparation, capsule, pill and tablet.

[0026] The third aspect of the technical scheme disclosed in the present application is a preparation method of a traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection, which comprises the following steps: S1: weigh 10g of radix pseudostellariae, 12g of red peony root, 10g of salvia miltiorrhiza, 6g of rhodiola, 6g of tangerine peel, 5g of pinellia ternata, 15g of poria cocos, 15g of poria cocos, 15g of patrinia, 15g of clematis, 12g of herba agrimoniae, 6g of licorice, 10g of chrysanthemum and 6g of cassia twig, and add sterile purified water to the above-mentioned traditional Chinese medicinal materials after pretreatment, and soak for 45-60min; S2: after soaking, first boil with high heat, then simmer for 30-45min, and filter out the first medicinal liquid; S3: continue to add sterile purified water to the residue in step S2, first boil with high heat, then simmer for 30-35min, pour out the second medicinal liquid, mix the first medicinal liquid with the second medicinal liquid, and get the combined medicinal liquid, which is the decoction; S4: further filter the decoction to get the filtrate, and sterilize and refrigerate the filtrate after concentration; S5: the sterilized and refrigerated filtrate in step S4 is made into any one of oral preparation, capsule, pill and tablet according to the conventional process.

[0027] Further, in steps S1 and S3, the amount of sterile purified water added is 8-10 times the weight of the traditional Chinese medicinal materials.

[0028] Compared with the prior art, the present application can produce the following beneficial effects: The traditional Chinese medicine formula of the present application is an empirical formula formulated according to the pathogenesis characteristics of insomnia after COVID-19 infection, and is based on the principle of benefiting qi and activating blood, resolving phlegm and dredging collaterals, and clearing away pestilence and tranquilizing the mind. The present formula takes Radix Pseudostellariae and Caulis Polygoni Multiflori as the monarch drugs, Radix Pseudostellariae benefits qi and generates fluid, and can treat the root of qi deficiency and yin damage after the epidemic, and Caulis Polygoni Multiflori nourishes blood and tranquilizes the mind, and directly attacks the symptoms of insomnia. The two drugs are used as the monarch drugs, and both support the healthy qi and tranquilize the mind. Radix Salviae Miltiorrhizae, Poria cocos and Sclerotium are used as the ministerial drugs. Radix Salviae Miltiorrhizae activates blood and dredges collaterals, and clears away heat from the heart and tranquilizes the mind, and helps Caulis Polygoni Multiflori to tranquilize the mind and improve blood stasis. Poria cocos and Sclerotium strengthen the spleen, remove dampness, calm the heart and tranquilize the mind, and help Radix Pseudostellariae to benefit qi, and also resolve phlegm and dampness to remove the causes of disturbing the mind, and assist the monarch drugs to enhance the therapeutic effect. Radix Paeoniae Rubra, Rhodiola, Citrus grandis, Rhizoma Pinelliae, Herba Lysimachiae and Chrysanthemum are used as the auxiliary drugs. Radix Paeoniae Rubra helps Radix Salviae Miltiorrhizae to activate blood and cool blood, and Rhodiola benefits qi and activates blood to enhance the power of supporting healthy qi and dredging collaterals. Citrus grandis and Rhizoma Pinelliae regulate qi and resolve phlegm to remove the evil of phlegm and dampness disturbing the mind. Herba Lysimachiae tonifies qi and nourishes yin, and astringes and contracts, and helps Radix Pseudostellariae to support healthy qi. Chrysanthemum clears away liver fire, brightens the eyes and tranquilizes the liver, and is used to treat possible liver fire disturbing the mind, and is used as the auxiliary drug to treat related pathogenesis together with the monarch and ministerial drugs. Licorice is used as the ministerial drug, and can benefit qi and harmonize the drugs, and make the whole formula compatible and harmonious, and the effects are coordinated. The drugs are synergistic and complementary to each other, and can improve the blood oxygen concentration of the human body, improve the oxygen carrying capacity of red blood cells, reduce blood viscosity, promote microcirculation, and eliminate residual toxins, and help patients to recover high-quality sleep. DETAILED DESCRIPTION

[0029] In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are a part of the embodiments of the present application, rather than all the embodiments of the present application.

[0030] It is found through research that the sleep disorder after COVID-19 infection may be related to hemagglutinin in the new coronavirus, because hemagglutinin can reduce the hypoxia tolerance of the human body, and thus cause sleep disorders. Hemagglutinin (HA) refers to a column-shaped hemagglutinin that can combine with receptors on the surface of red blood cells of humans, birds, pigs, guinea pigs and other animals to cause blood clotting, and is therefore called hemagglutinin. HA plays an important role in the process of virus introduction into host cells, and can assist the fusion of viral envelope and host cell membrane. HA is widely present in viruses and vaccines, and has immunogenicity. Anti-hemagglutinin antibodies can neutralize hemagglutinin.

[0031] Based on the above research results, the present application provides a traditional Chinese medicine composition for treating sleep disorders caused by COVID-19 infection, a traditional Chinese medicine preparation and a preparation method thereof, which are as follows: A traditional Chinese medicine composition for treating sleep disorders caused by COVID-19 infection, comprising the following weight parts of traditional Chinese medicinal materials: Taizishen 6-15g, Chishao 6-15g, Danshen 6-15g, Hongjingtian 3-9g, Huazao 3-9g, Jiangbanxia 3-9g, Fuling 10-20g, Fushen 10-20g, Baijiangcao 9-20g, Yejiaoteng 9-20g, Xianhecao 6-15g, Gancao 2-10g, Juhua 5-15g, Guizhi 3-10g.

[0032] Preferably, the traditional Chinese medicine composition comprises the following weight parts of traditional Chinese medicinal materials: Taizishen 8-12g, Chishao 8-12g, Danshen 10-12g, Hongjingtian 4-6g, Huazao 4-6g, Jiangbanxia 3-6g, Fuling 12-15g, Fushen 12-15g, Baijiangcao 12-15g, Yejiaoteng 12-15g, Xianhecao 8-12g, Gancao 4-8g, Juhua 8-10g, Guizhi 5-8g.

[0033] Preferably, the traditional Chinese medicine composition comprises the following weight parts of traditional Chinese medicinal materials: Taizishen 10g, Chishao 12g, Danshen 10g, Hongjingtian 6g, Huazao 6g, Jiangbanxia 5g, Fuling 15g, Fushen 15g, Baijiangcao 15g, Yejiaoteng 15g, Xianhecao 12g, Gancao 6g, Juhua 10g, Guizhi 6g.

[0034] A traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection, prepared from the traditional Chinese medicine composition described above, which is any one of a decoction, an oral preparation, a capsule, a pill, and a tablet.

[0035] A preparation method of a traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection, comprising the following steps: S1: respectively weigh Taizishen 10g, Chishao 12g, Danshen 10g, Hongjingtian 6g, Huazao 6g, Jiangbanxia 5g, Fuling 15g, Fushen 15g, Baijiangcao 15g, Yejiaoteng 15g, Xianhecao 12g, Gancao 6g, Juhua 10g, Guizhi 6g of traditional Chinese medicinal materials, and add 8-10 times the amount of sterile purified water to the pretreated traditional Chinese medicinal materials and soak for 45-60min; S2: after soaking, first boil with high heat, then simmer with low heat for 30-45min, and filter out the first medicinal liquid; S3: continue to add 8-10 times the amount of sterile purified water to the dregs in step S2, first boil with high heat, then simmer with low heat for 30-35min, pour out the second medicinal liquid, mix the first medicinal liquid and the second medicinal liquid, and obtain the combined medicinal liquid, which is the decoction; S4: further filter the decoction to obtain the filtrate, concentrate the filtrate, sterilize, and refrigerate; S5: The sterilized and refrigerated filtrate in step S4 is made into any one of oral agent, capsule, pill and tablet according to a conventional process.

[0036] It should be noted that, in order to facilitate preparation and patient medication, the present application mainly uses decoction. Example

[0037] The traditional Chinese medicinal materials of Radix Pseudoginseng 15g, Radix Paeoniae Rubra 15g, Radix Salviae Miltiorrhizae 15g, Rhodiolae Crenulatae 9g, Fructus Aurantii Immaturus 9g, Rhizoma Pinelliae 9g, Poria 20g, Sclerotium 20g, Herba Patriniae 20g, Caulis Polygoni Multiflori 20g, Herba Eupatorium Cannabifolii 15g, Radix Glycyrrhizae 10g and Flos Chrysanthemi 15g are weighed, cut into pieces after being washed and dried, 8 times the amount of sterile purified water is added, soaked for 45min, boiled with a large fire first, then simmered with a small fire for 35min, the first filtrate is filtered out, 8 times the amount of sterile purified water is added to the residue, boiled with a large fire first, then simmered with a small fire for 30min, the second filtrate is filtered out, the first filtrate and the second filtrate are mixed to obtain the combined filtrate, and the decoction is obtained. Example

[0038] The traditional Chinese medicinal materials of Radix Pseudoginseng 15g, Radix Paeoniae Rubra 15g, Radix Salviae Miltiorrhizae 15g, Rhodiolae Crenulatae 9g, Fructus Aurantii Immaturus 9g, Rhizoma Pinelliae 9g, Poria 20g, Sclerotium 20g, Herba Patriniae 20g, Caulis Polygoni Multiflori 20g, Herba Eupatorium Cannabifolii 15g, Radix Glycyrrhizae 10g and Flos Chrysanthemi 15g are weighed, cut into pieces after being washed and dried, 8 times the amount of sterile purified water is added, soaked for 45min, boiled with a large fire first, then simmered with a small fire for 35min, the first filtrate is filtered out, 8 times the amount of sterile purified water is added to the residue, boiled with a large fire first, then simmered with a small fire for 30min, the second filtrate is filtered out, the first filtrate and the second filtrate are mixed to obtain the combined filtrate, and the decoction is obtained. Example

[0039] The traditional Chinese medicinal materials of Radix Pseudoginseng 15g, Radix Paeoniae Rubra 15g, Radix Salviae Miltiorrhizae 15g, Rhodiolae Crenulatae 9g, Fructus Aurantii Immaturus 9g, Rhizoma Pinelliae 9g, Poria 20g, Sclerotium 20g, Herba Patriniae 20g, Caulis Polygoni Multiflori 20g, Herba Eupatorium Cannabifolii 15g, Radix Glycyrrhizae 10g and Flos Chrysanthemi 15g are weighed, cut into pieces after being washed and dried, 8 times the amount of sterile purified water is added, soaked for 45min, boiled with a large fire first, then simmered with a small fire for 35min, the first filtrate is filtered out, 8 times the amount of sterile purified water is added to the residue, boiled with a large fire first, then simmered with a small fire for 30min, the second filtrate is filtered out, the first filtrate and the second filtrate are mixed to obtain the combined filtrate, and the decoction is obtained. Example

[0040] Take the traditional Chinese medicinal materials of Radix Pseudoginseng 6g, Radix Paeoniae Rubra 6g, Radix Salviae Miltiorrhizae 6g, Rhodiolae Crenulatae 3g, Fructus Aurantii Immaturus 3g, Rhizoma Pinelliae Preparatum 3g, Poria 10g, Sclerotium 10g, Herba Patriniae 9g, Caulis Polygoni Multiflori 9g, Herba Agrimoniae 6g, Radix Glycyrrhizae 2g, Flos Chrysanthemi 5g, Ramulus Cinnamomi 3g, wash, dry and cut into pieces, add 10 times the amount of sterile purified water, soak for 45min, first boil with big fire, then turn to small fire and decoct for 45min, filter out the first decoction, continue to add 10 times the amount of sterile purified water to the residue, first boil with big fire, then turn to small fire and decoct for 35min, pour out the second decoction, mix the first and second decoctions to obtain the combined decoction, which is the decoction. Embodiment

[0041] Take the traditional Chinese medicinal materials of Radix Pseudoginseng 6g, Radix Paeoniae Rubra 6g, Radix Salviae Miltiorrhizae 6g, Rhodiolae Crenulatae 3g, Fructus Aurantii Immaturus 3g, Rhizoma Pinelliae Preparatum 3g, Poria 10g, Sclerotium 10g, Herba Patriniae 9g, Caulis Polygoni Multiflori 9g, Herba Agrimoniae 6g, Radix Glycyrrhizae 2g, Flos Chrysanthemi 5g, Ramulus Cinnamomi 3g, wash, dry and cut into pieces, add 10 times the amount of sterile purified water, soak for 45min, first boil with big fire, then turn to small fire and decoct for 45min, filter out the first decoction, continue to add 10 times the amount of sterile purified water to the residue, first boil with big fire, then turn to small fire and decoct for 35min, pour out the second decoction, mix the first and second decoctions to obtain the combined decoction, which is the decoction.

[0042] Study on the pathogenesis of sleep disorders after COVID-19 infection: Clinically, sleep disorders caused by COVID-19 infection are divided into four stages: invasion of pathogenic factors into the defensive aspect, invasion of pathogenic factors into the qi aspect, invasion of pathogenic factors into the nutrient aspect, and invasion of pathogenic factors into the blood aspect, as follows: 1) Invasion of pathogenic factors into the defensive aspect: When COVID-19 infects the defensive aspect, the pathogenic factor competes with the healthy qi, and both cold and fever are seen. The fever temperature is not high, but the yang does not enter the yin, so insomnia occurs. The first few days may have no effect on sleep, but if the fever persists, it will affect sleep. When the warm disease pathogenic factor subsides, although the person infected appears to be in a state of fatigue, the patient's pulse is calm, the body is comfortable, and the desire to sleep is produced. Sleep is the best way to recover the body.

[0043] 2) Invasion of pathogenic factors into the qi aspect: The dysfunction of the viscera and the imbalance of the viscera qi lead to insomnia. The pathogenic factor disturbs the viscera, the healthy qi competes with the pathogenic factor, the qi transformation is excessive, and the viscera is hyperactive. The heat in the qi aspect is seen, and the patient has high fever, excessive sweating, and fluid loss. Combined with the increase in body temperature, the brain is damaged, and insomnia begins to occur. If the invasion of pathogenic factors into the qi aspect leads to long-term high fever, the patient may have sleepiness, snoring, and difficulty speaking. This is due to the excessive heat in yangming, which affects the brain (heart) spirit. If the person infected appears to be sleepy, it means that the fever is too high. Snoring indicates that the pathogenic factor has damaged the fluid and caused airway obstruction.

[0044] 3) evil into the camp: high fever symptoms remain relatively constant state, due to lung and stomach heat, internal inversion of the dark, so as to move the liver wind. At this time, the patient's normal sleep cycle has been disrupted, so that the mind, convulsions, lethargy, can appear "night more sleep" syndrome, therefore, evil into the camp can appear insomnia and wakefulness disorders two cases.

[0045] 4) evil into the blood: at this time, the viscera and blood due to long-term consumption of blood stasis caused by insomnia, this stage, the patient's sleep from "lying up unrest", "irritated unrest", to the rash, delirium. Severe cases can also appear the syndrome of cold, that is, evil offending the pericardium, using the method of heat and collateral can promote wakefulness.

[0046] The traditional Chinese medicine composition of the present application is mainly aimed at insomnia caused by evil into the camp. Insomnia caused by new coronavirus infection is mostly related to factors such as consumption of epidemic evil and yin, disorder of qi movement, internal resistance of phlegm and dampness, and heart spirit deficiency. The formula of the present application is mainly based on the principles of tonifying qi and nourishing yin, promoting blood circulation and removing meridian obstruction, resolving phlegm and dampness, and nourishing heart and calming spirit. For the consumption of epidemic evil, use Taizishen and Xianhecao to tonify qi and support the healthy qi. For the stagnation of qi and blood stasis, use Danshen, Chishao and Hongjingtian to promote blood circulation and remove meridian obstruction. For the internal generation of phlegm and dampness (which may be related to the dysfunction of the spleen and stomach after infection), use Huazijiang, Jiangbanxia and Fuling to resolve phlegm and dampness. For heart spirit deficiency or disturbance, use Fushen, Yijiaoteng to nourish heart and calm spirit, and use Chrysanthemum to clear and drain the head and eyes to help calm the spirit.

[0047] The above shows and describes the basic principles, main features and advantages of the present application. Those skilled in the art should understand that the present application is not limited to the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the claimed present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for treating sleep disorders caused by coronavirus infection, characterized in that, The traditional Chinese medicine composition comprises the following weight parts of traditional Chinese medicinal materials: Taizishen 6-15g, Chishao 6-15g, Danshen 6-15g, Hongjingtian 3-9g, Huazao 3-9g, Jiangbanxia 3-9g, Fuling 10-20g, Fushen 10-20g, Baijiangcao 9-20g, Yejiaoteng 9-20g, Xianheshu 6-15g, Gancao 2-10g, Juhua 5-15g, Guizhi 3-10g.

2. The traditional Chinese medicine composition for treating sleep disorders caused by COVID-19 infection according to claim 1, characterized in that, The traditional Chinese medicine composition comprises the following weight parts of traditional Chinese medicinal materials: Taizishen 8-12g, Chishao 8-12g, Danshen 10-12g, Hongjingtian 4-6g, Huazao 4-6g, Jiangbanxia 3-6g, Fuling 12-15g, Fushen 12-15g, Baijiangcao 12-15g, Yejiaoteng 12-15g, Xianheshu 8-12g, Gancao 4-8g, Juhua 8-10g, Guizhi 5-8g.

3. The traditional Chinese medicine composition for treating sleep disorders caused by COVID-19 infection according to claim 1, characterized in that, The traditional Chinese medicine composition comprises the following weight parts of traditional Chinese medicinal materials: Taizishen 10g, Chishao 12g, Danshen 10g, Hongjingtian 6g, Huazao 6g, Jiangbanxia 5g, Fuling 15g, Fushen 15g, Baijiangcao 15g, Yejiaoteng 15g, Xianheshu 12g, Gancao 6g, Juhua 10g, Guizhi 6g.

4. A traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection, characterized in that, The traditional Chinese medicine preparation is prepared from the traditional Chinese medicine composition according to any one of claims 1-3.

5. The Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection according to claim 4, characterized in that, The traditional Chinese medicine preparation is any one of a decoction, an oral preparation, a capsule, a pill and a tablet.

6. The preparation method of the traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection according to claim 5, characterized in that, The method comprises the following steps: S1: 10g of Taizishen, 12g of Chishao, 10g of Danshen, 6g of Hongjingtian, 6g of Huazao, 5g of Jiangbanxia, 15g of Fuling, 15g of Fushen, 15g of Baijiangcao, 15g of Yejiaoteng, 12g of Xianheshu, 6g of Gancao, 10g of Juhua and 6g of Guizhi are weighed respectively, and the above traditional Chinese medicinal materials are pretreated and then added into sterile purified water and soaked for 45-60min; S2: after soaking, the mixture is boiled with a large fire first and then is boiled with a small fire for 30-45min, and the first medicinal liquid is filtered out; S3: sterile purified water is further added into the residue in step S2, the mixture is boiled with a large fire first and then is boiled with a small fire for 30-35min, the second medicinal liquid is poured out, the first medicinal liquid is mixed with the second medicinal liquid, and the combined medicinal liquid is obtained, which is a decoction; S4: the decoction is further filtered to obtain a filtrate, and the filtrate is concentrated, sterilized and refrigerated; S5: the sterilized and refrigerated filtrate in step S4 is processed into any one of an oral preparation, a capsule, a pill and a tablet according to a conventional process.

7. The preparation method of the traditional Chinese medicine preparation for treating sleep disorders caused by COVID-19 infection according to claim 6, characterized in that, In steps S1 and S3, the amount of sterile purified water added is 8-10 times the weight of the traditional Chinese medicinal materials.