Oil-soluble atomized liquid and preparation method thereof

Abstract

The invention discloses an oil-soluble atomized liquid and a preparation method thereof, and relates to the technical field of electronic cigarette atomized liquids, and the oil-soluble atomized liquid comprises the following components by weight: 5-10% of nicotine stearate, 5-10% of an emulsifier, 5-10% of an emulsifier, and the balance of a solvent. 15 to 20% of essence; 3-4% or 10-12% of a cooling agent; 0.5-1% of a sweetening agent; the content of the caprylic capric triglyceride is greater than or equal to 55%; wherein the essence takes glycerol triacetate as a solvent; according to the technical scheme provided by the invention, the caprylic capric triglyceride is adopted as the solvent, so that an oil-soluble system is created, the original experience of smoking can be better restored, and the electronic cigarette has the smoking taste closer to that of a traditional cigarette.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of electronic cigarette atomization liquid, in particular to an oil-soluble atomization liquid and a preparation method thereof. BACKGROUND

[0002] At present, the atomization liquid system scheme of the electronic cigarette is mainly to take propylene glycol (PG) and glycerol (VG) as the main solvent, and most of the components can be metabolized by the human body circulation, which is safe for the human body. However, this system also has some limitations. Most of the tobacco natural ingredients are oil-soluble, and the solubility effect in the water-soluble propylene glycol and glycerol system is poor, and the original experience of smoking cannot be well restored. SUMMARY

[0003] The main purpose of the present application is to provide an oil-soluble atomization liquid, which aims to provide an oil-soluble system to restore the original experience of smoking.

[0004] To achieve the above purpose, the oil-soluble atomization liquid provided by the present application comprises the following components by weight percentage:

[0005] Nicotine stearate, 5-10%;

[0006] Essence, 15-20%;

[0007] Cooling agent, 3-4% or 10-12%;

[0008] Sweetener, 0.5-1%;

[0009] The balance is caprylocaproyl glycerol, and the content is greater than or equal to 55%;

[0010] Among them, the essence is an essence with glyceryl trivalerate as the solvent.

[0011] The present application also provides a preparation method of an oil-soluble atomization liquid, which is used for preparing the above-mentioned oil-soluble atomization liquid, comprising the following steps:

[0012] A. Preparation of nicotine stearate: nicotine and stearic acid are mixed and reacted at a nicotine content of 20-50% by weight to obtain nicotine stearate;

[0013] B. Mixing components: nicotine stearate prepared in step A is mixed with essence, cooling agent and sweetener in proportion, the addition amount of essence is 15-20%, the addition amount of sweetener is 0.5-1%, and the balance is caprylocaproyl glycerol and glyceryl trivalerate (wherein the content of caprylocaproyl glycerol is greater than or equal to 55%), and the oil-soluble atomization liquid is obtained after mixing and stirring.

[0014] In an embodiment, the cooling agent is a solid cooling agent, which is directly mixed in step B and dissolved at 20-25℃ (ultrasonic assistance can be used for dissolution), and the amount of the cooling agent added is 3-4% by weight.

[0015] In an embodiment, the cooling agent is a solution of a solid cooling agent dissolved in an alpha-pinene solvent in advance, with a concentration of 10-30%, which is directly mixed in step C, and the amount of the cooling agent added is 10-12% by weight.

[0016] In an embodiment, the weight percentage of nicotine in the nicotine stearate is 36.3%, and the weight percentage of stearic acid is 63.7% (i.e., the molar ratio of nicotine to stearic acid = 1.0:1.0).

[0017] In an embodiment, the nicotine content of the oil-soluble atomized liquid is 30mg / ml.

[0018] In an embodiment, the sweetener is stevioside.

[0019] In an embodiment, the oil-soluble atomized liquid has a boiling point of 400-416.6℃ and a specific heat capacity of 1.79-1.846KJ / (kg·℃).

[0020] In an embodiment, the cooling agent is WS-23 or menthol.

[0021] In an embodiment, the amount of the sweetener added is 1%.

[0022] The technical solution of the present application creates an oil-soluble system by using capric caprylic acid glyceride as a solvent, which can better restore the original experience of smoking, and thus makes the electronic cigarette have a taste closer to that of traditional cigarettes. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0024] It should be noted that if the embodiments of the present application involve directional indications (such as up, down, left, right, front, back, etc.), the directional indications are only used to explain the relative positional relationship, movement condition, etc. between components in a certain posture, and if the certain posture changes, the directional indications also change accordingly.

[0025] In addition, if the description of "first", "second" and the like is involved in the embodiments of the present application, the description of "first", "second" and the like is only for the purpose of description, and cannot be understood as indicating or implying the relative importance of the indicated technical features or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second" can be explicitly or implicitly included at least one of the features. In addition, if "and / or" or "and / or" appears throughout the text, it means that the three parallel schemes include the A scheme, or the B scheme, or the A and B schemes. In addition, the technical solutions of each embodiment can be combined with each other, but it must be based on the realization of the ordinary skilled in the art, when the combination of technical solutions appears contradictory or unachievable, it should be considered that the combination of technical solutions does not exist, nor in the protection scope required by the present application.

[0026] Electronic cigarette is an electronic product that simulates traditional cigarettes, mainly including battery, atomizer and tobacco tar; the battery is used to power the atomizer, and the atomizer generates aerosol by heating the tobacco tar containing nicotine, propylene glycol, glycerol and spices for people to inhale, thereby simulating the traditional cigarette smoking; electronic cigarette does not contain tar but still contains nicotine, which is used as a smoking aid or cigarette substitute by some people.

[0027] At present, the tobacco tar of electronic cigarette generally adopts a propylene glycol (PG) and glycerol (VG) based atomization system. The propylene glycol and / or glycerol system is safe for the human body, most of the components can be metabolized through the human body circulation, and both have good solubility and stability, can effectively carry nicotine and spices, PG can provide throat irritation similar to smoking, and VG can produce a large amount of smoke and enhance the sweet taste.

[0028] However, most of the flavor substances in traditional tobacco are oil-soluble, while the propylene glycol and / or glycerol system is a water-soluble system, so the solubility of the flavor substances in traditional tobacco in the propylene glycol and / or glycerol system is poor, and the propylene glycol and / or glycerol system is difficult to restore the smoking experience of traditional cigarettes.

[0029] To solve the above problems, the present application provides an oil-soluble atomizing liquid, which aims to improve the restoration degree of electronic cigarette to the smoking experience of traditional cigarettes. Specifically, the oil-soluble atomizing liquid provided by the present application comprises the following components by weight percentage:

[0030] Nicotine stearate, 5%-10%;

[0031] Essence, 15%-20%;

[0032] Cooling agent, 3%-4% or 10%-12%;

[0033] Sweetener, 0.5%-1%;

[0034] The balance is glyceryl octanoate decanoate; and it is greater than or equal to 55wt%;

[0035] The essence is an essence with glyceryl triacetate as a solvent.

[0036] According to the above, the present application solves the problem of insufficient solubility of traditional PG and / or VG system for oil-soluble tobacco flavor substances by using glyceryl octanoate decanoate (ODO) as the main solvent and combining with tobacco flavor essence with glyceryl triacetate as the solvent to form an oil-soluble system, which significantly improves the degree of restoration of the taste of traditional cigarettes by electronic cigarettes. Moreover, the use of nicotine stearate makes nicotine exist stably in the oil-soluble system, avoids crystallization and precipitation, and reduces the free nature of nicotine, thereby reducing the irritation to the oral cavity.

[0037] The present application also provides a preparation method of the oil-soluble atomizing liquid.

[0038] A. Preparation of nicotine stearate: nicotine and stearic acid are mixed at a content of 20-50wt% of nicotine, stirred at room temperature for 5-20min to form an oil paste of nicotine stearate, the content of nicotine in the nicotine stearate is 20-50wt%, and the content of stearic acid is 80-50wt%;

[0039] B. Mixing components: the nicotine stearate, tobacco flavor essence, cooling agent and stevioside prepared in step A are mixed in proportion, the addition amount of the essence is 15-20%, the addition amount of the sweetener is 0.5-1%, and the balance is glyceryl octanoate decanoate and glyceryl triacetate. After mixing and stirring, an oil-soluble atomizing liquid is obtained, the nicotine content of the oil-soluble atomizing liquid is 1-5mg / ml, the azeotropic point is 400-416.6℃, and the specific heat capacity is 1.79-1.846KJ / (kg·℃).

[0040] In the above preparation method, the nicotine stearate is prepared step by step and the proportion of the solvent is accurately controlled to ensure uniform dispersion of each component, thereby improving the stability and consistency of the atomizing liquid. In addition, the room temperature stirring process simplifies the production process and reduces energy consumption. Furthermore, the nicotine content is set to 1-5mg / kg, which meets the trend of low nicotine products, reduces the risk of addiction, and at the same time meets the user's demand for nicotine intake. Finally, the azeotropic point and specific heat capacity of the oil-soluble atomizing liquid prepared by the present application are more close to the combustion characteristics of traditional cigarettes, thereby improving the heat and smoke quality during smoking.

[0041] In the present application, since the oil-soluble system is set, most of the sweeteners, cooling agents and flavors that can be used in the water-soluble system cannot be applied in the oil-soluble system; therefore, in the above steps, the flavor is uniformly tobacco-flavored flavor with glyceryl triacetate as the solvent, without any water, ethanol and propylene glycol; glyceryl triacetate is a short-chain glyceride that can be well integrated with medium-chain glyceride; the cooling agent is one of WS-23 or menthol, both of which have high solubility in the oil-soluble system and long-lasting cooling sensation, which can enhance the cooling taste of the product and improve the user experience; however, considering that WS-23 and menthol both have molecular polarity, the present application provides two ways of adding cooling agents; one, the cooling agent can be a solid cooling agent, when the cooling agent is a solid cooling agent, it is directly mixed in step B and dissolved at 20-25°C, and the amount of cooling agent added is 3-4% by weight; the second, the cooling agent can also be a solution of a solid cooling agent dissolved in an alpha-pinene solvent, with a concentration of 10-30%, the cooling agent is directly mixed in step B, and the amount of cooling agent added is 10-12% by weight. The operation of directly mixing and heating the solid cooling agent to dissolve avoids the use of additional solvents, reduces production costs, and at the same time ensures that the cooling agent is fully dissolved in the oil-soluble system, enhancing the uniformity of the cooling sensation release; and the 10%-30% solution of the cooling agent pre-dissolved in the alpha-pinene solvent can significantly reduce the azeotropic point and the specific heat capacity of the system, thereby reducing the energy required for heating, improving the atomization efficiency, and at the same time maintaining the stability of the cooling agent. It should be noted that the way of adding the cooling agent can be selected according to the actual product demand and taste setting requirements, and the solid or liquid addition method has its own advantages, and one of them can be chosen.

[0042] Since almost all sugar substitutes except steviol glycoside do not have oil solubility, the sweetener used in the present application is steviol glycoside, which provides natural sweetness in the oil-soluble system within its limited solubility, thereby avoiding the potential risks of using synthetic sweeteners. In addition, the amount of sweetener added is 1%, which can achieve the best sweetness balance within the solubility range of steviol glycoside, avoiding the bitter taste or turbidity problem caused by excessive addition.

[0043] The following is further illustrated by examples:

[0044] Example 1

[0045] Nicotine stearate (molar ratio of nicotine to stearic acid = 1:0.5): 8wt%

[0046] WS-23: 3.5wt%

[0047] Chinese tobacco flavor: 18wt%

[0048] Steviol glycoside: 0.8wt%

[0049] Caprylic / capric triglyceride: 55wt%

[0050] The balance is triacetin.

[0051] Example 2

[0052] Nicotine stearate (nicotine to stearic acid molar ratio = 1:1.2): 10 wt%

[0053] Cooling agent solution (10% menthol + 90% α-pinene): 12wt%

[0054] Classic tobacco flavoring: 15wt%

[0055] Steviosides: 0.6 wt%

[0056] Caprylic / capric triglyceride: 60 wt%

[0057] The balance is triacetin.

[0058] Example 3

[0059] Nicotine stearate (nicotine to stearic acid molar ratio = 1.0:1.0): 8 wt%

[0060] Menthol: 3 wt%

[0061] Mild tobacco flavoring: 17%,

[0062] Steviosides: 0.5 wt%

[0063] Caprylic / capric triglyceride: 65wt%

[0064] The balance is triacetin.

[0065] Comparative experimental design

[0066]

[0067] Control group setup

[0068]

[0069] Key performance data comparison

[0070] Subject selection: Individuals aged 18-45 years with no history of respiratory diseases and normal taste / smell function who work in the nebulizer industry, and who uniformly use VOOPOO devices (0.7Ω, 25W).

[0071] Four indicators are set, including aroma volume, harmony, throat hit, and off-flavors. Each evaluation item has a maximum scale of 5 points, and each evaluation item is scored in units of 1 point. The specific evaluation criteria are shown in Table 1.

[0072] Table 1

[0073]

[0074]

[0075] Evaluation method and result statistics: Provide samples and sensory evaluation standard table to 15 professional taste testers, score each index according to the table. Collect all single scores of the taste testers, calculate the arithmetic mean of each single score, and round to one decimal place. Sum the arithmetic mean of each index to get the total score. The specific results are shown in Table 2.

[0076] Table 2

[0077] amount of aroma harmony throat hit off-notes total score (max. 20) water-soluble control 3.8 4.4 4.0 4.2 16.4 example 1 4.1 3.8 4.3 4.2 16.4 example 2 3.9 4.2 3.8 3.4 15.3 example 3 4.4 4.6 2.6 4.2 15.8

[0078] According to the sensory test results, the oil-soluble nicotine salt in the application, after the oil-soluble atomization system, obtains a good sensory experience, filling the blank of the current oil-soluble atomization system.

[0079] Heat calculation

[0080] The azeotropic point of the original propylene glycol glycerol system is calculated according to 40% VG and 60% PG, T = T1xW1 + T2xW2, which is about 229 degrees. The specific heat capacity is C = C1M1 + C2M2, which is about 2.386 KJ / (Kg / C).

[0081] According to Q = mc(δ)t, the total heat per kilogram heated to boiling is 487.4 m(KJ).

[0082] The azeotropic point of the existing system is about 416.6 degrees according to 80%ODO and 20%triacetate, and the specific heat capacity is 1.846 KJ / (Kg / C). The total heat per kilogram heated to boiling is 722.9 m(KJ) per kilogram.

[0083] The results of the a-pinene scheme used here can reduce the azeotropic point to below 400 degrees, the specific heat capacity to 1.79, and the total heat requirement to 588 m(KJ) per kilogram.

[0084] The traditional cigarette produces an open flame temperature of 600-800℃ when smoking. The azeotropic point of the existing oil-soluble system is calculated to be closer to the original cigarette system than the original propylene glycol glycerol system.

[0085] According to the power calculation of the equipment, the original equipment boils to produce smoke in 50ms, and the existing scheme needs to absorb more heat, which will produce a delay of about 20%, that is, 60ms, which has little effect on users and existing equipment.

[0086] The above merely illustrates the embodiments of the present application, and is not intended to limit the patent scope of the present application. Any equivalent structural transformation, direct / indirect application in other related technical fields, or the like, made according to the technical concept of the present application, shall be included in the patent protection scope of the present application.

Claims

1. An oil-soluble atomizing liquid characterized by comprising, The oil-soluble atomizing liquid comprises the following components by weight percentage: Nicotine stearate, 5-10%; Essence, 15-20%; Cooling agent, 3-4% or 10-12%; Sweetener, 0.5-1%; The balance is capryl capric glycerin, and the content is ≥55%; The essence is essence with glycerol triacetate as solvent.

2. The method of producing an oil-soluble atomized liquid as claimed in claim 1, characterized by, The oil-soluble atomizing liquid comprises the following steps: A. Preparation of nicotine stearate: nicotine and stearic acid are mixed and reacted to obtain nicotine stearate with nicotine content of 20-50% by weight; B. Mixing components: nicotine stearate prepared in step A is mixed with essence, cooling agent and sweetener in proportion, the addition amount of essence is 15-20wt%, the addition amount of sweetener is 0.5-1wt%, and the balance is capryl capric glycerin and glycerol triacetate (wherein the content of capryl capric glycerin is ≥55wt%), and the oil-soluble atomizing liquid is obtained after mixing and stirring.

3. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent and then adding the surfactant to the mixture. The cooling agent is a solid cooling agent, which is directly mixed in step B and dissolved at 20-25℃ (ultrasonic assistance can be used for dissolution), and the addition amount of the cooling agent is 3-4% by weight.

4. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent and then adding the surfactant to the mixture. The cooling agent is a solid cooling agent solution dissolved in α-pinene solvent in advance, and the concentration is 10-30%, the cooling agent solution is directly mixed in step B, and the addition amount of the cooling agent solution is 10-12% by weight.

5. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent and then adding the surfactant to the mixture. The molar ratio of nicotine to stearic acid in the nicotine stearate is 1:0.5-2.0, and the nicotine stearate is prepared by ultrasonic assisted reaction at 25-50℃ (frequency 40kHz, power 300-500W).

6. The method of claim 5, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent and then adding the surfactant to the mixture. The nicotine content of the oil-soluble atomizing liquid is 11-53mg / ml.

7. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent and then adding the surfactant to the mixture. The sweetener is stevioside.

8. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent, and then adding the surfactant to the mixture. The azeotropic point of the oil-soluble atomizing liquid is 400-416.6℃, and the specific heat capacity is 1.79-1.846KJ / (kg·℃).

9. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent, and then adding the surfactant to the mixture. The cooling agent is WS-23 or menthol.

10. The method of claim 2, wherein the oil-soluble atomized liquid is prepared by adding the oil-soluble active ingredient to the oil-soluble solvent, and then adding the surfactant to the mixture. The addition amount of the sweetener is 1wt%. The oil-soluble atomizing liquid comprises the following components by weight percentage: Nicotine stearate, 5-10%; Essence, 15-20%; Cooling agent, 3-4% or 10-12%; Sweetener, 0.5-1%; The balance is capryl capric glycerin, and the content is ≥55%; The essence is essence with glycerol triacetate as solvent. The oil-soluble atomizing liquid comprises the following steps: A. Preparation of nicotine stearate: nicotine and stearic acid are mixed and reacted to obtain nicotine stearate with nicotine content of 20-50% by weight; B. Mixing components: nicotine stearate prepared in step A is mixed with essence, cooling agent and sweetener in proportion, the addition amount of essence is 15-20wt%, the addition amount of sweetener is 0.5-1wt%, and the balance is capryl capric glycerin and glycerol triacetate (wherein the content of capryl capric glycerin is ≥55wt%), and the oil-soluble atomizing liquid is obtained after mixing and stirring. The cooling agent is a solid cooling agent, which is directly mixed in step B and dissolved at 20-25℃ (ultrasonic assistance can be used for dissolution), and the addition amount of the cooling agent is 3-4% by weight. The cooling agent is a solid cooling agent pre-dissolved in α-pinene solvent, and the concentration is 10-30%, the cooling agent solution is directly mixed in step B, and the addition amount of the cooling agent solution is 10-12% by weight. The molar ratio of nicotine to stearic acid in the nicotine stearate is 1:0.5-2.0, and the nicotine stearate is prepared by ultrasonic assisted reaction at 25-50℃ (frequency 40kHz, power 300-500W). The nicotine content of the oil-soluble atomizing liquid is 11-53mg / ml. The sweetener is stevioside. The azeotropic point of the oil-soluble atomizing liquid is 400-416.6℃, and the specific heat capacity is 1.79-1.846KJ / (kg·℃). The cooling agent is WS-23 or menthol. The addition amount of the sweetener is 1wt%.

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