Wireless recording device for mouse experiment

Abstract

The invention relates to the technical field of animal physiological monitoring, in particular to a wireless recording device for mouse experiments, which comprises a fixing component, a communication module and a plurality of acquisition components are arranged on the fixing component, the acquisition components are used for acquiring physiological signals of mice, and the fixing component is used for limiting relative positions of the acquisition components and the mice. The fixing assembly comprises a fixing vest made of a plastic material, a cavity is formed in the fixing vest, the side wall of the cavity is fixedly connected with a first pull rope made of an elastic material, the other end of the first pull rope is fixedly connected with the other side wall of the cavity, the side wall of the fixing vest is coated with macromolecule self-adhesive glue, the cavity communicates with a pump assembly, and the pump assembly is used for adjusting the pressure in the cavity. The device is used for reducing the influence of a cable for collecting physiological signals of a mouse on normal activities of the mouse in the mouse anesthesia experiment process.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of animal physiological monitoring, in particular to a wireless recording device for mouse experiments. BACKGROUND

[0002] In the vast field of biomedical research, mice play a crucial role as experimental animals. Their high genetic similarity to humans, relatively short reproductive cycle, and ease of management make them an ideal choice for disease modeling, drug screening, and efficacy evaluation. In experimental operations involving mice, especially those that may cause pain or discomfort to the mice, such as surgical and research procedures, the use of anesthesia techniques is particularly important.

[0003] Anesthesia techniques not only concern the welfare of experimental animals, but also are a key factor in ensuring the accuracy and reliability of experimental results. Proper anesthesia management can reduce the stress response of mice during the experiment, thereby avoiding interference with the experimental results. At the same time, anesthesia also helps researchers complete surgical operations more smoothly and improves experimental efficiency.

[0004] Among them, mouse anesthesia experiment recording technology, as an indispensable part of the field of biomedical research, plays a crucial role. This technology aims to closely monitor the physiological changes of mice under anesthesia, providing valuable information for researchers to understand the physiological functions of living organisms and the mechanisms of drug action. Biological signals, as a direct reflection of the internal physiological activities of living organisms, have a very high research value for researchers. These signals include both electrical signals (such as electrocardiogram, electroencephalogram) and non-electrical signals (such as blood pressure, body temperature). By collecting and analyzing these signals, researchers can comprehensively and deeply understand the physiological state of living organisms, pathological changes, and drug effects, providing scientific basis for the prevention and treatment of diseases.

[0005] However, in the existing mouse anesthesia experiment recording technology, the collection method of physiological signals has certain limitations. Although the traditional electrode sheet or detection needle collection method can obtain the physiological signals of mice, the design of the cable brings many inconveniences to the experimental operation. The restraint of the cable not only limits the normal activity of the mouse, but also may cause interference and distortion in the signal transmission process, thereby affecting the accuracy of the data. Therefore, how to improve the existing collection method and improve the accuracy and reliability of the data has become a problem that researchers need to solve. SUMMARY

[0006] To solve the above problems, the present application provides a wireless recording device for mouse experiments, which is used to reduce the influence of the cable for collecting physiological signals of mice on the normal activity of mice during the mouse anesthesia experiment.

[0007] In order to achieve the above object, the technical scheme of the present application is as follows: a wireless recording device for mouse experiment, comprising a fixing assembly, a communication module and a plurality of collecting assemblies are arranged on the fixing assembly, the collecting assemblies are used for collecting physiological signals of the mouse, the fixing assembly is used for limiting the relative position of the collecting assemblies and the mouse, the fixing assembly comprises a fixing vest made of plastic material, a cavity is arranged in the fixing vest, a first pull rope made of elastic material is fixedly connected to the side wall of the cavity, the other end of the first pull rope is fixedly connected to the other side wall of the cavity, the side wall of the fixing vest is coated with high-molecular self-adhesive glue, the cavity is communicated with a pump assembly, the pump assembly is used for adjusting the pressure in the cavity, and the collecting assemblies are arranged on the inner side wall of the fixing vest.

[0008] Further, a control system is arranged, the control system is used for controlling the communication module to output the physiological signals to a user, the control system is further used for acquiring first deformation information of the first pull rope, acquiring body size information of the mouse according to the first deformation information, and controlling the pump assembly to work according to the body size information.

[0009] Further, the control system comprises a first strain gauge and a controller.

[0010] The first strain gauge is used for collecting the first deformation information of the first pull rope.

[0011] The controller is used for acquiring the shoulder width of the mouse according to the first deformation information, calculating the body size information of the mouse according to the shoulder width of the mouse, and controlling the pump assembly to work according to the body size information of the mouse until the first deformation information returns to a set value.

[0012] Further, the fixing assembly further comprises a fixing belt, the two ends of the fixing belt are crossed, the two ends of the fixing belt are fixedly connected to the outer side wall of the fixing vest, and any one end of the fixing belt is close to the cavity, the other end of the fixing belt is away from the cavity, and the collecting assemblies are fixedly connected to the side wall of the fixing belt.

[0013] Further, the fixing belt comprises a sub-belt and a mother belt, the mother belt is wrapped outside the sub-belt, and the end of the sub-belt away from the fixing vest is provided with a piston, the mother belt is communicated with the pump assembly, and the mother belt and the cavity are both provided with a first electromagnetic valve at the communication position of the pump assembly.

[0014] Further, a plurality of second pull ropes are arranged on the outer side wall of the fixing belt, one end of the second pull rope is fixedly connected to the outer side wall of the mother belt or the sub-belt, and the other end of the second pull rope is fixedly connected to the outer side wall of the fixing vest.

[0015] Further, the control system further comprises a second strain gauge, the second strain gauge is used for collecting second deformation information of the second pull rope, the controller acquires length information from the top of the skull to the shoulder of the mouse according to the second deformation information, the first deformation information and the size of the fixing belt, and controls the pump assembly and the first electromagnetic valve to work according to the length information.

[0016] Further, the mobile assembly comprises a plurality of driving cavities formed in the side wall of the cavity close to the mouse, the driving cavities are in communication with the cavity, and a second electromagnetic valve is arranged at the communication position of the driving cavities and the cavity; a driving rod is arranged on the side wall of the driving cavity close to the mouse, the driving rod is used to drive the collection assembly to approach or move away from the skin of the mouse; a plurality of arc-shaped holes are formed in the side wall of the driving cavity close to the mouse, the arc-shaped holes are arranged in the circumferential direction of the driving rod, and a third electromagnetic valve is arranged on the hole wall of each arc-shaped hole; and the controller is further used to control the first electromagnetic valve, the second electromagnetic valve, the third electromagnetic valve and the pump assembly to work according to the physiological signal.

[0017] Further, a plurality of deformation parts are arranged on the fixed vest in the longitudinal direction of the fixed vest.

[0018] Further, the control system further comprises a plurality of auxiliary strain gauges, the auxiliary strain gauges are used to collect auxiliary deformation information of the first pull rope or the second pull rope, and the controller is used to correct the first deformation information or the second deformation information according to the auxiliary deformation information.

[0019] Further, the collection assembly is an electrode patch or a monitoring needle.

[0020] The technical principles and beneficial effects of the above scheme are as follows:

[0021] In the scheme, the design of the fixed assembly realizes the integration of the mouse physiological signal collection structure, which greatly simplifies the experimental equipment required, effectively reduces the experimental cost, and simplifies the operation process. In particular, through the carefully designed fixed vest structure, the operator only needs to assist the mouse to wear the vest, and the installation of the collection assembly can be easily completed, which further reduces the complexity of the experimental operation.

[0022] Compared with the prior art, the scheme adopts a wireless signal transmission technology to collect the physiological signals of the mouse, which completely discards the traditional connection mode of cables and the like, thereby avoiding the interference of the cables and the like on the normal activities of the mouse, and ensuring the accuracy of the experimental results. In addition, the design of the cavity and the like in the scheme is also quite ingenious, which not only ensures that the first pull rope can flexibly adjust the size of the vest, but also skillfully avoids the possible compression of the mouse caused by the elasticity of the pull rope, thereby ensuring that the normal activities of the mouse are not affected, and further improving the accuracy of the experiment.

[0023] Additional aspects and advantages of the application will be made apparent from the following description. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 The isometric view of the wireless recording device for mouse experiment according to the embodiment of the application;

[0025] Figure 2Front view of wireless recording device embodiment for mouse experiment of the present application;

[0026] Figure 3 For Figure 2 A-A section view in the middle;

[0027] Figure 4 For Figure 3 Enlarged view at B in the middle;

[0028] Figure 5 Top view of wireless recording device embodiment 2 for mouse experiment of the present application;

[0029] Figure 6 Circuit schematic of wireless recording device embodiment for mouse experiment of the present application.

[0030] The reference signs in the drawings of the specification include: 1, fixed assembly; 11, fixed vest; 111, cavity; 112, first pull rope; 12, fixed belt; 13, second pull rope; 14, moving assembly; 141, driving cavity; 142, driving rod; 143, arc-shaped hole. DETAILED DESCRIPTION

[0031] The technical solutions of the present application will be described clearly and completely below in combination with the drawings. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative efforts fall within the scope of protection of the present application.

[0032] In the description of the present application, it should be noted that the orientations or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0033] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through an intermediate medium; it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0034] The following is further described in detail through specific embodiments:

[0035] Embodiment 1:

[0036] As shown in the accompanying drawings: A wireless recording device for mouse experiments, comprising a fixing assembly 1, the fixing assembly 1 is provided with a communication module and a plurality of collection assemblies (not shown in the figure), the collection assemblies are used to collect physiological signals of the mouse, the fixing assembly 1 is used to limit the relative position of the collection assemblies and the mouse, and ensure effective collection of the physiological signals, the collection assemblies are electrode patches or monitoring needles, and the collection assemblies are electrode patches in this embodiment. Figure 1 - The accompanying drawings show: The fixing assembly 1 includes a fixing vest 11 made of plastic material, the side walls of the fixing vest 11 are coated with high-molecular self-adhesive glue, the fixing vest 11 is provided with a cavity 111, the cavity 111 is provided with a first pull rope 112 made of elastic material and bonded and fixed to the side wall, the other end of the first pull rope 112 is bonded and fixed to the other side wall of the cavity 111, and the cavity 111 is communicated with a pump assembly, which is a gas pump (not shown in the figure) in this embodiment, the pump assembly is used to adjust the pressure in the cavity 111, and the collection assemblies are arranged on the inner side wall of the fixing vest 11 and are bonded and fixed to the fixing vest 11. Figure 6 The fixing assembly 1 includes a fixing vest 11 made of plastic material, the side walls of the fixing vest 11 are coated with high-molecular self-adhesive glue, the fixing vest 11 is provided with a cavity 111, the cavity 111 is provided with a first pull rope 112 made of elastic material and bonded and fixed to the side wall, the other end of the first pull rope 112 is bonded and fixed to the other side wall of the cavity 111, and the cavity 111 is communicated with a pump assembly, which is a gas pump (not shown in the figure) in this embodiment, the pump assembly is used to adjust the pressure in the cavity 111, and the collection assemblies are arranged on the inner side wall of the fixing vest 11 and are bonded and fixed to the fixing vest 11.

[0037] The fixing assembly 1 includes a fixing vest 11 made of plastic material, the side walls of the fixing vest 11 are coated with high-molecular self-adhesive glue, the fixing vest 11 is provided with a cavity 111, the cavity 111 is provided with a first pull rope 112 made of elastic material and bonded and fixed to the side wall, the other end of the first pull rope 112 is bonded and fixed to the other side wall of the cavity 111, and the cavity 111 is communicated with a pump assembly, which is a gas pump (not shown in the figure) in this embodiment, the pump assembly is used to adjust the pressure in the cavity 111, and the collection assemblies are arranged on the inner side wall of the fixing vest 11 and are bonded and fixed to the fixing vest 11.

[0038] The control system further includes a first strain gauge and a controller; the first strain gauge is installed at a position close to the cavity 111 of the first pull rope 112 and is bonded and fixed to the first pull rope 112, the controller is bonded and fixed to the fixing vest 11, the first strain gauge, the communication module and the collection assemblies are electrically connected to the controller, and the first strain gauge is used to collect first deformation information of the first pull rope 112; the controller is used to obtain the shoulder width of the mouse according to the first deformation information, calculate the body size information of the mouse according to the shoulder width of the mouse, control the pump assembly to work according to the body size information of the mouse, and return the first deformation information to a set value.

[0039] The specific implementation process is as follows: when the device is used, the first pull rope 112 is elastic, so that in the initial state, part of the position of the fixing vest 11 is pulled into the cavity 111 by the first pull rope 112.

[0040] After the mouse is anesthetized, the positions on the body of the mouse that may contact the fixing vest 11 are depilated, then the fixing vest 11 is worn on the mouse, the position of the fixing vest 11 is located on the back of the mouse, the collection assemblies on the back of the mouse are pressed to make the collection assemblies on the back of the mouse adhere to the skin of the mouse, and then the device is started.

[0041] When the volume of the mouse is smaller than the size of the fixed vest 11, at this time the fixed vest 11 is worn in a loose state, the first pull rope 112 is in a relaxed state without being pulled by the side wall of the chamber 111, and in this process, the first strain gauge continuously collects the first deformation information of the first pull rope 112 (the deformation amount is proportional to the resistance generated by the first strain gauge), and since the first pull rope 112 is relaxed at this time, the first deformation does not change significantly, and since the first strain gauge is arranged at the position of the first pull rope 112 close to the side wall of the chamber 111, during bending, due to the characteristics of the catenary, the curvature of the first pull rope 112 close to the two ends of the chamber 111, i.e. the position near the suspension point of the first pull rope 112, is small, thereby avoiding damage to the first strain gauge caused by excessive bending curvature during the deformation of the first pull rope 112.

[0042] Within a set time, if the first deformation information does not change significantly, it can be judged that the size of the fixed vest 11 is greater than or equal to the mouse, at this time the controller controls the pump assembly to work, and gas is pumped into the side wall of the chamber 111 close to the other side of the fixed vest 11, and as the gas pressure rises, since the resistance to be overcome by the first pull rope 112 is greater than the resistance to be overcome by the chamber 111, the gas pressure preferentially fills the chamber 111, and as the chamber 111 is filled, the chamber 111 gradually wraps the outer side wall of the fixed vest 11, and as the gas pressure rises, the fixed vest 11 continuously enters the chamber 111, gradually reducing the width of the fixed vest 11, so that the fixed vest 11 fits the size of the mouse, and since the high-molecular self-adhesive glue is designed, when the fixed vest 11 enters the chamber 111, the side walls of the fixed vest 11 are bonded to each other, thereby realizing the fixing of the width of the fixed vest 11, and when the gas pressure in the chamber 111 rises to a set value, the chamber 111 is filled, at this time the resistance to be overcome by the fixed vest 11 to be deformed is greater than the resistance to be overcome by the first pull rope 112, at this time the chamber 111 pulls the first pull rope 112, and when the first pull rope 112 starts to deform, i.e. when the first deformation information appears, the fixed vest 11 is adjusted to the appropriate width, the controller controls the pump assembly to stop working, and the adjustment of the width of the fixed vest 11 is completed.

[0043] When the volume of the mouse is greater than the size of the fixed vest 11, the mouse pulls the fixed vest 11, at this time, due to the fact that the elastic modulus of the first deformation part is greater than the first pull rope 112, the mouse exerts on the fixed vest 11 to deform the first pull rope 112, and the fixed vest 11 part position is separated from the chamber 111, the length of the fixed vest 11 out of the chamber 111 corresponds to the deformation amount of the first pull rope 112, and the initial width of the fixed vest 11, the initial length of the first pull rope 112 and the elastic modulus thereof are known, so the length of the fixed vest 11 out of the chamber 111 can be calculated, that is, the actual length of the fixed vest 11 can be obtained, thereby obtaining the shoulder width of the mouse and other information, that is, the body type information of the mouse is obtained, and the controller controls the pump assembly to work, and the pump assembly pumps gas into the chamber 111, so that the chamber 111 is filled, and in the process of filling the chamber 111, the side wall of the fixed vest 11 is adhered under the action of the high-molecular self-adhesive glue, and the shape of the chamber 111 is fixed, and the process is stopped until the first deformation information changes, at this time, the chamber 111 has been filled, and the adjustment of the size of the fixed vest 11 is completed.

[0044] Subsequently, the user can press the collection assembly to make the collection assembly adhere to the skin of the mouse, and in the use process, the collection assembly continuously collects the physiological electrical signals emitted by the mouse, and the controller controls the communication module to transmit the physiological electrical signals to the user, and the user can evaluate the physiological state of the mouse according to the physiological electrical signals.

[0045] Compared with the traditional mouse physiological electrical signal collection scheme, the present scheme uses wireless transmission technology to avoid cable interference with the normal activity of the mouse, and due to the fixed design of the collection assembly and the fixed vest 11, the user can roughly position the position on the mouse body where the electrode patch needs to be pasted or the detection needle needs to be inserted, and the design of the fixed vest 11 with adjustable width can adapt to mice of different body types, reduce the risk of the collection assembly falling off, and the design of the chamber 111 can exert a certain pressure on the skin of the mouse by filling the chamber 111, thereby giving the mouse a certain wrapping feeling, improving the safety of the mouse, and reducing the probability of stress of the mouse, and the filled chamber 111 can give the first pull rope 112 a certain tension, thereby offsetting the size of the force exerted on the mouse body by the first pull rope 112, reducing the discomfort of the mouse in the experiment process, and avoiding the influence of the experiment on the normal activity and data collection of the mouse.

[0046] Embodiment 2:

[0047] As shown in the accompanying Figure 5 The difference between the embodiment 1 and the embodiment 2 is that the fixed assembly 1 further comprises a fixed belt 12, the fixed belt 12 is crossed at both ends, the fixed belt 12 is adhered and fixed to the outer side wall of the fixed vest 11 at both ends, and the fixed belt 12 is close to the chamber 111 at one end and away from the chamber 111 at the other end, and the collection assembly is adhered and fixed to the side wall of the fixed belt 12.

[0048] The fixed band 12 comprises a female band and a male band, the female band is wrapped outside the male band, and the male band is provided with a piston away from one end of the fixed vest 11, the female band is communicated with the pump assembly, and the female band and the chamber 111 are both provided with a first electromagnetic valve communicated with the pump assembly.

[0049] The outer side wall of the fixed band 12 is provided with a plurality of second pull ropes 13 made of elastic material, one end of the second pull rope 13 is fixedly bonded to the outer side wall of the female band or the male band, and the other end of the second pull rope 13 is fixedly bonded to the outer side wall of the fixed vest 11.

[0050] The control system further comprises a second strain gauge, the second strain gauge is fixedly bonded to the second pull rope 13, the second strain gauge is used to collect second deformation information of the second pull rope 13, the second strain gauge is electrically connected with the controller, the controller obtains length information from the top of the mouse skull to the shoulder according to the second deformation information, the first deformation information and the size of the fixed band 12, and controls the pump assembly and the first electromagnetic valve to work according to the length information from the top of the mouse skull to the shoulder.

[0051] The specific implementation process is as follows: when using the device, the top of the mouse skull is depilated, and the fixed band 12 is buckled on the mouse head position while wearing the fixed vest 11, and the mouse is fixed by its ears, in the subsequent size adjustment process of the fixed vest 11, with the adjustment of the fixed vest 11, the fixed vest 11 drives the two ends of the fixed band 12 to move closer or farther away from each other, when the volume of the mouse is small, the two ends of the fixed band 12 move closer to each other, so that the circumference of the circle formed by the fixed band 12 becomes larger, but the distance between the highest point of the circle and the fixed vest 11 becomes smaller, so as to adapt to the shorter head height of the small mouse, and when facing a larger mouse, the two ends of the fixed band 12 move away from each other, so that the circumference of the circle formed by the fixed band 12 becomes shorter, but the distance between the highest point of the circle and the fixed vest 11 gradually becomes larger, so as to adapt to the longer head height of the larger mouse.

[0052] Compared with the prior art, the size of the fixed band 12 for fixing the biological electric type collection assembly for collecting the mouse brain can be adjusted synchronously according to the adjustment of the size of the fixed vest 11, so that the device can meet the needs of mice of different sizes, and compared with the scheme of using traditional glue and the like for fixing, the operation difficulty of the scheme is lower, which can adapt to users of different professional levels and is helpful to simplify the experimental steps.

[0053] Meanwhile, in the scheme, the male band and the female band are used to pump gas into or out of the female band through the pump main angle and the first electromagnetic valve, so as to adjust the air pressure in the female band, and then drive the male band to move through the air pressure, so as to adjust the total length of the fixed band 12, compared with the prior art, the scheme can avoid the situation that the fixed band 12 falls off the mouse head due to the small volume of the mouse.

[0054] The design of the second pull rope 13 increases the fixing point between the fixing belt 12 and the fixing vest 11, thereby improving the stability of the fixing belt 12, so as to avoid the falling of the fixing belt 12 to a certain extent during the movement of the mouse. At the same time, since the second pull rope 13 has a certain elasticity, the comfort of the device can be improved, and the restraint of the fixing belt 12 can be avoided, so that the mouse struggles. In this process, the second strain gauge continuously collects the second deformation information of the second pull rope 13, and according to the second deformation information, the deformation amount of the second pull rope 13 during use can be obtained, and the comfort degree of the fixing belt 12 can be judged. When the second deformation information is too large, the pressure of the fixing belt 12 applied to the head of the mouse is too large. At this time, the controller controls the pump assembly and the first electromagnetic valve to work to the female belt type pump road body quality, thereby driving the sub-belt to move and adjust the length of the fixing belt 12, so that the fixing belt 12 is adjusted to the appropriate length, that is, the second deformation information is within the set range, thereby further improving the comfort of the device, avoiding the falling of the equipment caused by the struggle of the mouse during the experiment, and affecting the experiment.

[0055] Example 3:

[0056] As shown in the accompanying drawings, Figure 4 The difference from example 2 is that it also includes a moving assembly 14, the moving assembly 14 includes a plurality of driving cavities 141 opened in the side wall of the chamber 111 close to the mouse, the driving cavities 141 are all in communication with the chamber 111, and the communication part of the driving cavities 141 and the chamber 111 is provided with a second electromagnetic valve. The driving rod 142 is arranged on the side wall close to the mouse of the driving cavity 141, and the driving rod 142 is used to drive the collection assembly to approach or move away from the mouse skin. A plurality of arc-shaped holes 143 are opened on the side wall close to the mouse of the driving cavity 141, the arc-shaped holes 143 are circumferentially arranged around the driving rod 142, and the third electromagnetic valve is arranged on the hole wall of the arc-shaped hole 143. The controller is also used to control the first electromagnetic valve, the second electromagnetic valve, the third electromagnetic valve and the pump assembly to operate according to the physiological signal.

[0057] The specific implementation process is as follows: in the process of using the device, the controller determines whether the collection assembly moves to a suitable position according to the biological signal. When the biological signal indicates that the position of the collection assembly is not suitable and effective signals cannot be collected, the controller controls the pump assembly, the second electromagnetic valve and the third electromagnetic valve at the corresponding position to work. Part of the gas in the parameter is sprayed onto the skin of the mouse through the hole wall of the arc-shaped hole 143. Under the action of air pressure, the collection assembly at the position falls off from the skin of the mouse. Due to the action of the high-molecular self-adhesive glue, the collection assemblies at other positions will not move obviously. Subsequently, the controller controls the first electromagnetic valve and the pump assembly to work, adjusts the air pressure in the chamber 111, drives the collection assembly at the position to move left and right by a unit distance. Subsequently, the controller controls the second electromagnetic valve to open, the third electromagnetic valve and the first electromagnetic valve to close, and controls the pump assembly to work at the same time. By pumping part of the gas into the driving cavity 141, the driving cavity 141 is expanded, so as to push the collection assembly close to the skin of the mouse through the driving rod 142, complete the fixation of the collection assembly, and then determine whether the position can collect effective data according to the biological signal again. If effective data cannot be collected, the above steps are repeated until effective experimental data can be collected.

[0058] According to the scheme of the prior art, the position can be adjusted to some extent, the collection assembly can be arranged, and the effectiveness of the collected data can be determined, so as to further reduce the working steps of the experimental personnel and reduce the difficulty of experimental operation.

[0059] Embodiment 4:

[0060] As shown in the accompanying drawings, Figure 1 The difference between the embodiment 3 and the embodiment 4 is that the fixed vest 11 is provided with a plurality of deformation parts

[0061] The specific implementation process is as follows: before using the device, the experimental personnel can pull the fixed vest 11 longitudinally according to the body length of the mouse, so that the deformation parts are deformed correspondingly, so as to adapt to mice of different lengths. Compared with the prior art, the setting of the deformation parts can expand the mouse size that can be applied to the device to some extent.

[0062] Embodiment 5:

[0063] As shown in the accompanying drawings, Figure 1 The difference between the embodiment 4 and the embodiment 5 is that the control system further includes a plurality of auxiliary strain gauges, the auxiliary strain gauges are used to collect auxiliary deformation information of the first pull rope 112 or the second pull rope 13, and the controller is used to correct the first deformation information or the second deformation information according to the auxiliary deformation information

[0064] The specific implementation process is as follows: in the process of using the device, the auxiliary strain piece works at the same time as the corresponding first strain piece or second strain piece works, and the auxiliary controller judges the deformation state of the first pull rope 112 or the second pull rope 13 by collecting the auxiliary deformation information of the first pull rope 112 or the second pull rope 13.

[0065] Compared with the prior art, the scheme can avoid stress concentration caused by uneven material in the manufacturing process of the first pull rope 112 and the second pull rope 13, thereby further avoiding data errors and improving the judgment accuracy of the device.

[0066] Obviously, the above embodiments are only examples for clear illustration, and are not limitations on the embodiments. Based on the above description, other different forms of changes or variations can be made by those skilled in the art. Here, all the embodiments need not and cannot be exhausted. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. A wireless recording device for mouse experiment, comprising a fixing assembly (1), a communication module and a plurality of acquisition assemblies are arranged on the fixing assembly (1), the acquisition assemblies are used for acquiring physiological signals of the mouse, and the fixing assembly (1) is used for limiting the relative position of the acquisition assemblies and the mouse, characterized in that, The fixed assembly (1) comprises a fixed vest (11) made of plastic material, a cavity (111) is arranged in the fixed vest (11), a first pull rope (112) made of elastic material is fixedly connected to the side wall of the cavity (111), the other end of the first pull rope (112) is fixedly connected to the other side wall of the cavity (111), the side wall of the fixed vest (11) is coated with high-molecular self-adhesive glue, the cavity (111) is communicated with a pump assembly, the pump assembly is used for adjusting the pressure in the cavity (111), and a collection assembly is arranged on the inner side wall of the fixed vest (11). The control system is used for controlling the communication module to output the physiological signal to the user, acquiring the first deformation information of the first pull rope (112), acquiring the body size information of the mouse according to the first deformation information, and controlling the pump assembly to work according to the body size information.

2. The wireless recording device for mouse experiments of claim 1, wherein, The control system comprises a first strain gauge and a controller. The first strain gauge is used for collecting the first deformation information of the first pull rope (112). The controller is used for acquiring the shoulder width of the mouse according to the first deformation information, calculating the body size information of the mouse according to the shoulder width of the mouse, and controlling the pump assembly to work according to the body size information of the mouse until the first deformation information returns to a set value.

3. The wireless recording device for mouse experiments of claim 2, wherein, The fixed assembly (1) further comprises a fixed band (12), the two ends of the fixed band (12) are crossed, the two ends of the fixed band (12) are fixedly connected to the outer side wall of the fixed vest (11), and the end of the fixed band (12) close to the cavity (111) and the other end of the fixed band (12) away from the cavity (111), and the collection assembly is fixedly connected to the side wall of the fixed band (12).

4. The wireless recording device for mouse experiments of claim 3, wherein, The fixed band (12) comprises a sub-band and a mother band, the mother band is wrapped outside the side wall of the sub-band, and the end of the sub-band away from the fixed vest (11) is provided with a piston, the mother band is communicated with the pump assembly, and the communication positions of the mother band and the cavity (111) with the pump assembly are both provided with a first electromagnetic valve.

5. The wireless recording device for mouse experiments of claim 4, wherein, The outer side wall of the fixed band (12) is provided with a plurality of second pull ropes (13), one end of the second pull rope (13) is fixedly connected to the outer side wall of the mother band or the sub-band, and the other end of the second pull rope (13) is fixedly connected to the outer side wall of the fixed vest (11).

6. The wireless recording device for mouse experiments of claim 5, wherein, The control system further comprises a second strain gauge, the second strain gauge is used for collecting second deformation information of the second pull rope (13), the controller acquires length information from the top of the mouse's head to the shoulder according to the second deformation information, the first deformation information and the size of the fixed band (12), and controls the pump assembly and the first electromagnetic valve to work according to the length information.

7. The wireless recording device for mouse experiments of claim 6, wherein, The mobile assembly (14) comprises a plurality of driving cavities (141) formed in the side wall of the chamber (111) close to the mouse, the driving cavities (141) are in communication with the chamber (111), and the communication part of the driving cavities (141) and the chamber (111) is provided with a second electromagnetic valve; the driving cavities (141) are provided with driving rods (142) on the side wall close to the mouse, the driving rods (142) are used to drive the collection assembly to approach or move away from the skin of the mouse, and a plurality of arc-shaped holes (143) are formed in the side wall close to the mouse of the driving cavities (141); the arc-shaped holes (143) are arranged in the circumferential direction of the driving rods (142), and the arc-shaped holes (143) are provided with third electromagnetic valves on the hole walls; and the controller is further used to control the first electromagnetic valve, the second electromagnetic valve, the third electromagnetic valve and the pump assembly to work according to the physiological signal.

8. The wireless recording device for mouse experiments of claim 7, wherein, The fixed vest (11) is provided with a plurality of deformation parts, and the deformation parts are arranged in the longitudinal direction of the fixed vest (11).

9. The wireless recording device for mouse experiments of claim 8, wherein, The control system further comprises a plurality of auxiliary strain gauges, the auxiliary strain gauges are used to collect auxiliary deformation information of the first pull rope (112) or the second pull rope (13), and the controller is used to correct the first deformation information or the second deformation information according to the auxiliary deformation information.

10. The wireless recording device for mouse experiments of claim 9, wherein, The collection assembly is an electrode patch or a monitoring needle.

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