Pharmaceutical excipient high efficiency mixing device

Abstract

The application discloses a kind of high-efficiency mixing devices of pharmaceutical excipients, belongs to material mixing technical field, including mixing cylinder, support leg seat being arranged at the four sides of the bottom of mixing cylinder, installation chassis being arranged at the bottom of support leg seat, heating coil being arranged in the empty layer of mixing cylinder, lower exhaust pipe being communicated with the bottom of mixing cylinder and exhaust pipe being connected with the lower end of lower exhaust pipe, the rotor shaft of motor is penetrated through top cover and is connected with spin pipe, the bottom of spin pipe is connected with connector, and outer support stirring frame and inner support stirring frame are installed on the two sides of connector;Top sealing mechanism is installed on the inner wall of the inner cylinder of mixing cylinder, and top sealing mechanism is used to control and adjust the upper space of pharmaceutical excipients, and top gas suction mechanism is arranged on spin pipe;Liquid level control exhaust mechanism is installed on top sealing mechanism;Gas pressure sensor and liquid level meter are respectively arranged on top sealing mechanism.No need for full-time period vacuum operation, and in the process of stirring, part of small molecule effective components and water generated between reaction of material liquid are retained, and the quality of excipient product is guaranteed.

Description

Technical Field

[0001] This invention belongs to the field of material mixing technology, specifically relating to a high-efficiency mixing device for pharmaceutical excipients. Background Technology

[0002] Pharmaceutical excipients are substances, other than the active ingredient, contained in pharmaceutical preparations. Besides acting as excipients, carriers, and improving stability, pharmaceutical excipients also have important functions such as solubilization, co-solubilization, and sustained-release. Their use and preparation quality significantly affect the quality, safety, and efficacy of pharmaceutical products.

[0003] In the production of some liquid pharmaceutical excipients, different solid raw materials need to be mixed with pure water to prepare a liquid, which is then stored in different pressurized tanks for later use. During production, the liquid from the different pressurized tanks is added to a mixing tank in proportion and stirred to obtain the liquid pharmaceutical excipient. This production method concentrates the quantitative mixing process with pure water during the off-season, allows the liquid to be stored in large, sterile pressurized tanks, and ensures faster and more uniform mixing, resulting in high production efficiency. This method is particularly suitable for supplying excipients to drugs that urgently need to be marketed in large quantities. Secondly, compared to traditional production methods, the mixing and preparation of the liquid effectively avoids the formation of solidified raw materials on the inner wall of the mixing tank during the production of liquid pharmaceutical excipients, extending the cleaning cycle and further enabling high-efficiency production of liquid pharmaceutical excipients.

[0004] When the liquid material in the pressurized tank is quantitatively discharged into the mixing tank by a quantitative pump, a large number of bubbles will be generated during the mixing process due to the entrainment of gas in the mixing tank and the influence of the liquid material. Compared with the bubbles generated by stirring pure water, the liquid mixture has a smaller surface tension and the bubbles are more persistent after they form.

[0005] As is well known, in the production of auxiliary chemical products, bubbles generated by stirring can hinder the mixing and mass transfer processes of reactants, affecting the mixing and reaction efficiency of the effective components in the liquid. Therefore, a common operating method, in addition to controlling the stirring speed, is to maintain a constant pressure and vacuum in the mixing tank throughout the stirring process. This method can remove the gas entrained in the liquid during mixing, thereby effectively reducing the amount of bubbles generated during stirring.

[0006] However, this continuous vacuum operation puts a certain strain on the inner material of the mixing tank, especially as some small-molecule active ingredients and water generated by the reaction between the liquids are quickly carried out, which has a certain impact on the quality of the auxiliary materials. Summary of the Invention

[0007] The purpose of this invention is to provide a high-efficiency mixing device for pharmaceutical excipients to solve the problems existing in the prior art.

[0008] To achieve the above objectives, the present invention provides the following technical solution: a high-efficiency mixing device for pharmaceutical excipients, comprising a mixing cylinder, support legs disposed on four sides at the bottom of the mixing cylinder, a mounting base disposed at the bottom of the support legs, a heating coil disposed in the hollow layer inside the mixing cylinder, a lower drain pipe connected to the bottom of the mixing cylinder, and a drain pipe connected to the lower end of the lower drain pipe, wherein a plugging mechanism is disposed inside the drain pipe, the plugging mechanism being used to seal the bottom of the mixing cylinder and discharge the mixed pharmaceutical excipients inside the mixing cylinder;

[0009] An ultrasonic transducer is installed on the inner side wall of the mixing cylinder. A top cover is provided on the top of the mixing cylinder. A top cover is installed on the top of the top cover. A motor is installed on the top of the top cover. The rotor shaft of the motor passes through the top cover and is connected to a spiral tube. A connector is connected to the bottom of the spiral tube. An outer stirring frame and an inner stirring frame are installed on both sides of the connector.

[0010] The inner wall of the mixing cylinder is equipped with a top sealing mechanism, which is used to control and adjust the upper space of the pharmaceutical excipients. The spiral tube is equipped with a top air suction mechanism, which is used to evacuate the space between the liquid level of the pharmaceutical excipients in the mixing cylinder and the top sealing mechanism.

[0011] The top sealing mechanism is equipped with a liquid level control and discharge mechanism, which is used to control the amount of raw materials discharged into the inner cylinder of the mixing drum. The top sealing mechanism is equipped with a pressure sensor and a level gauge. The pressure sensor is used to measure the gas-liquid pressure between the liquid level of the pharmaceutical excipients in the mixing drum and the top sealing mechanism. The level gauge is used to detect the liquid level height of the pharmaceutical excipients in the mixing drum.

[0012] A control mechanism is installed on one side of the mixing cylinder. The control mechanism is used to analyze the real-time liquid level signal input from the liquid level gauge and the real-time air pressure signal input from the air pressure sensor, and to control the lifting and lowering of the top sealing mechanism, the suction action of the top air suction mechanism, and the discharge and stop operation of the liquid level control and discharge mechanism. The operation of the plug discharge mechanism is controlled by calculating the stirring time.

[0013] Compared with the prior art, the beneficial effects of the present invention are:

[0014] The pharmaceutical excipient high-efficiency mixing device of this invention involves the addition of liquid in batches controlled by a liquid level control mechanism. A top-gas suction mechanism then removes the gas from the upper part of the liquid in the mixing cylinder. Combined with ultrasonic vibration caused by the operation of an ultrasonic transducer, any gas originally present in the liquid is also effectively removed, creating a vacuum. A top-sealing mechanism then moves down to isolate the liquid in a space containing only the liquid itself. During stirring, this effectively prevents air bubbles from remaining in the liquid. Furthermore, this setup eliminates the need for continuous vacuuming and retains some small-molecule active ingredients and water generated during the stirring process, ensuring the quality of the excipient product.

[0015] The pharmaceutical excipient high-efficiency mixing device of the present invention, under the auxiliary control of the control mechanism, the top air suction mechanism, the top sealing mechanism and the liquid level control and discharge mechanism operate alternately and orderly according to the set instructions, with a high degree of automation and convenient use. Attached Figure Description

[0016] Figure 1 This is a front view schematic diagram of the present invention;

[0017] Figure 2 for Figure 1 A partial cross-sectional diagram;

[0018] Figure 3 This is an enlarged structural diagram of the connection point of the discharge cylinder according to the present invention;

[0019] Figure 4 for Figure 2 Enlarged structural diagram of the discharge cylinder;

[0020] Figure 5 for Figure 2 A magnified structural diagram at point a;

[0021] Figure 6 for Figure 2 A magnified structural diagram at point b;

[0022] Figure 7 for Figure 2 A magnified structural diagram at point c;

[0023] Figure 8 for Figure 2 A schematic diagram of the enlarged structure of the central control mechanism;

[0024] Figure 9 This is a schematic diagram showing the connections of the modules in the development board of this invention.

[0025] In the diagram: 1. Mixing cylinder, 2. Support leg seat, 3. Pipe row, 4. Lower pipe row, 5. Support plate, 6. Electric telescopic rod I, 7. Connecting plate, 8. Drum row, 9. Sealing ring, 10. Guide hole, 11. Heating coil, 12. Ultrasonic vibrator, 13. Top cover, 14. Top cover, 15. Motor, 16. Rotary tube, 17. Connector, 18. Outer stirring frame, 19. Inner stirring frame, 20. Suction hole, 21. Sealed bearing, 22. Cover, 23. Connecting pipe, 24. Suction pump, 25. Pressure sealing plate, 26. Sealing support ring I, 27. Sealing support ring II, 28. Pressure sealing ring, 29. Pressure protrusion ring, 30. Load-bearing screw, 31. Locking nut, 32 outer sealing ring, 33 discharge port, 34 solenoid valve, 35 telescopic pipe, 36 feed pipe, 37 electric telescopic rod II, 38 air pressure sensor, 39 level gauge, 40 temperature sensor, 41 inner support plate I, 42 pressure plug, 43 soft sleeve, 44 connecting rod, 45 air extraction hole, 46 support connecting rod, 47 movable sealing ring, 48 inner support plate II, 49 support plate, 50 spring, 51 fixed rod, 52 control box, 53 development board, 54 integrated relay, 55 driver group, 56 industrial computer, 101 mounting base, 701 movable opening. Detailed Implementation

[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0027] See Figure 1 and Figure 2 A high-efficiency mixing device for pharmaceutical excipients includes a mixing cylinder 1, support legs 2 bolted to the four sides of the bottom of the mixing cylinder 1, a mounting base 101 welded to the bottom of the support legs 2, a heating coil 11 fused to the inner hollow layer of the mixing cylinder 1, a lower drain pipe 4 connected to the bottom of the mixing cylinder 1 and a drain pipe 3 connected to the flange at the lower end of the lower drain pipe 4, and a plugging mechanism is provided in the drain pipe 3. The plugging mechanism is used to seal the bottom of the mixing cylinder 1 and discharge the mixed pharmaceutical excipients in the mixing cylinder 1.

[0028] The power supply terminal of the heating coil 11 is connected to the power output terminal of the thermostat via a cable. The main power input terminal of the thermostat is connected to an external power source via a cable. The heating coil 11 is 2 cm away from the outer layer of the mixing cylinder 1.

[0029] The other end of pipe 3 is connected to an industrial pump, which then draws the finished product into the filling tank on the filling line.

[0030] When the plugging and draining mechanism is in operation, it can effectively discharge the pharmaceutical excipients that have been mixed into finished products; when the plugging and draining mechanism is disconnected from the flow, it can be flattened against the inner bottom of the mixing cylinder 1, thereby avoiding the situation where some liquid material accumulates in the plugging and draining mechanism and cannot be effectively mixed and stirred.

[0031] An ultrasonic transducer 12 is bolted to the inner wall of the mixing cylinder 1. The power cord of the ultrasonic transducer 12 is connected to the electrical signal output terminal of the ultrasonic generator via a cable. A top cover 13 is provided on the top of the mixing cylinder 1. Sealing ring grooves are provided on the outer edge of the top of the mixing cylinder 1 and the outer edge of the lower end of the top cover 13. A rubber ring is pressed into the sealing ring groove, and the mixing cylinder 1 and the top cover 13 are circumferentially and evenly locked with bolts. A top cover 14 is integrally provided on the top of the top cover 13. A motor 15 is bolted to the center of the top of the top cover 14. The motor 15 is a servo motor. The rotor shaft of the motor 15 passes through the top cover 14 and is flanged to the spiral tube 16. The bottom flange of the spiral tube 16 is connected to the connector 17. The connector 17 is used to bolt the outer stirring frame 18 and the inner stirring frame 19 on both sides.

[0032] A filter screen is also provided on one side of the top cover 14 to allow air circulation between the inside and outside of the top cover 14, providing conditions for the unobstructed upward movement of the sealing plate 25.

[0033] It is worth noting that when no stirring is being performed, the rotation angle of the motor 15 is controlled by the servo motor controller to satisfy the following conditions: the outer stirring bracket 18 is located at the front and the inner stirring bracket 19 is located at the rear. Under these conditions, the liquid level gauge 39 is not affected in sensing the liquid level.

[0034] The operation of motor 15 drives the rotating tube 16 to rotate, which in turn drives the outer and inner stirring frames 18 and 19 to rotate, thus achieving thorough stirring of the liquid in mixing drum 1. The ultrasonic transducer 12 is selected at 40kHz. During operation, it can cause high-frequency vibration of the liquid in mixing drum 1, thereby accelerating the breaking up of bubbles, improving gas flowability, accelerating gas buoyancy, and providing conditions for the top air suction mechanism to remove gas from the liquid.

[0035] A top-position sealing mechanism is installed on the inner wall of the mixing cylinder. The top-position sealing mechanism is used to control and adjust the upper space of the pharmaceutical excipients. A top-air suction mechanism is set on the spiral tube 16. The top-air suction mechanism is used to evacuate the space between the liquid level of the pharmaceutical excipients in the mixing cylinder 1 and the top-position sealing mechanism.

[0036] The top air suction mechanism first evacuates the area of ​​the mixing cylinder 1 that is not filled with liquid. After completion, the top sealing mechanism continuously lowers the area of ​​the non-filled liquid until it is attached to the surface of the liquid. With this setting, it is not necessary to maintain the vacuum in the mixing cylinder 1 for a long time, and gas can be effectively prevented from mixing into the liquid.

[0037] A liquid level control and discharge mechanism is installed on the top sealing mechanism. The liquid level control and discharge mechanism is used to control the amount of raw materials discharged into the inner cylinder of the mixing cylinder 1. A pressure sensor 38 and a liquid level gauge 39 are respectively installed on the top sealing mechanism. The liquid level gauge 39 is a radar liquid level gauge. The pressure sensor 38 is used to measure the gas-liquid pressure between the liquid level of the pharmaceutical excipients in the mixing cylinder 1 and the top sealing mechanism. The liquid level gauge 39 is used to detect the liquid level height of the pharmaceutical excipients in the mixing cylinder 1.

[0038] A control mechanism is installed on the right side of the mixing cylinder 1. The control mechanism is used to analyze the real-time liquid level signal input by the liquid level gauge 39 and the real-time air pressure signal input by the air pressure sensor 38, and to control the lifting and lowering height of the top sealing mechanism, the suction action of the top air suction mechanism, and the discharge and stop operation of the liquid level control and discharge mechanism. The operation of the plug discharge mechanism is controlled by calculating the stirring time.

[0039] Under the control mechanism, the top sealing mechanism and the top air suction mechanism are automatically operated to perform top air extraction and space reduction.

[0040] See Figure 1 , Figure 2 , Figure 3 and Figure 4 The filling mechanism includes a support plate 5 bolted to the upper right side of the filling pipe 3, an electric telescopic rod 6 bolted to the support plate 5, the electric telescopic rod 6 being a stepper motor driven electric telescopic rod, a connecting plate 7 bolted to the top rod of the electric telescopic rod 6, a filling cylinder 8 slidably installed inside the lower filling pipe 4, the filling cylinder 8 being a cylindrical structure with an open bottom and a closed top, annular grooves provided on the upper and lower parts of the outer side of the filling cylinder 8, a sealing ring 9 bonded with resin glue in the annular groove, the sealing ring 9 being a rubber soft ring, and the outer wall of the rubber soft ring being closedly pressed against the inner wall of the lower filling pipe 4, a guide hole 10 evenly provided in the upper circumference of the filling cylinder 8, the inner diameter of the guide hole 10 being 10 cm; a movable opening 701 is provided on the right side of the middle part of the lower filling pipe 4, the connecting plate 7 passing through the movable opening 701 and bolted to the right side of the filling cylinder 8.

[0041] When the top rod of the electric telescopic rod 6 extends, it drives the discharge cylinder 8 to move upward, so that the guide hole 10 is exposed into the mixing cylinder 1, thereby discharging the well-mixed liquid auxiliary material in the mixing cylinder 1; when the top rod of the electric telescopic rod 6 retracts, it drives the discharge cylinder 8 to move downward until its top surface is level with the bottom layer of the mixing cylinder 1, which can effectively prevent the liquid material from entering the discharge pipe 3 and ensure that the liquid material in the lower part is fully mixed.

[0042] See Figure 2 , Figure 5 and Figure 7 The top air suction mechanism includes suction holes 20 evenly arranged in the upper part of the spiral tube 16. Sealed bearings 21 are installed on the upper and lower parts of the spiral tube 16 and at the suction holes 20. A cover 22 is installed on the outer ring of the sealed bearing 21. A connecting pipe 23 is integrally provided on the left side of the cover 22. The left end of the connecting pipe 23 passes through the left side of the top cover 14 and is flanged to the suction end of the suction pump 24.

[0043] With this setup, without affecting the rotation of the swirl tube 16 driven by the motor 15, the pump 24 can evacuate the non-loading space inside the mixing cylinder 1 through the swirl tube 16.

[0044] The top-air suction mechanism also includes an inner support plate 41 integrally mounted on the inner wall of the spiral tube 16. The inner support plate 41 has a plug hole, which is a tapered circular hole wider at the top and narrower at the bottom. A pressure plug 42 is pressed tightly inside the plug hole. The pressure plug 42 has a tapered structure wider at the top and narrower at the bottom. A soft sleeve 43, made of rubber, is tightly fitted onto the pressure plug 42. A connecting rod 44 is integrally mounted at the lower center of the soft sleeve 43. Suction holes 45 are evenly distributed circumferentially in the middle of the spiral tube 16. The upper part of the connecting rod 44... A circumferentially uniformly welded support rod 46 is provided, and a movable sealing ring 47 is fixed to the outer side of the support rod 46 with screws. The movable sealing ring 47 is a circular ring structure and seals the port of the air extraction hole 45. A seamlessly welded inner support plate 48 is provided inside the spiral tube 16 and located at the lower part of the air extraction hole 45. One end of the connecting rod 44 slides through the inner support plate 48 and is bolted to the support plate 49. A spring 50 is sleeved on the connecting rod 44, and the two ends of the spring 50 are respectively supported by the inner support plate 48 and the support plate 49.

[0045] A gas inlet pipe is also connected to one side of the mixing cylinder 1, and one end of the gas inlet pipe is connected to the helium pressurization tank via a solenoid valve. When the sealing plate 25 covers the evacuation port 45, it will seal the gas inlet pipe port on one side of the mixing cylinder 1. When the solenoid valve is opened, the helium in the helium pressurization tank will quickly enter the mixing cylinder 1, providing conditions for the drainage work after stirring.

[0046] Spring 50 is a compression-rebound type, with an initial compression-rebound force of 20 Newtons. Through the elastic support force of spring 50, the movable sealing ring 47 keeps the air extraction hole 45 sealed, and the soft sleeve 43 is pressed against the inner wall of the plug hole, thereby effectively ensuring that the gas in the mixing cylinder 1 enters the swirl tube 16. When the pump 24 is running, the suction force drives the plug 42 and the movable sealing ring 47 to move upward, thereby extracting gas from the mixing cylinder 1 through the air extraction hole 45.

[0047] It is worth noting that, in actual operation, the liquid level of the feed solution should be controlled at a position 3 mm below the air extraction hole 45.

[0048] See Figure 2 and Figure 6 The top sealing mechanism includes a pressure sealing plate 25 slidably disposed inside the mixing cylinder 1. A sealing support ring 26, a sealing support ring 27, and a pressure sealing ring 28 are respectively disposed from bottom to top inside the sealing mounting hole. The material of the sealing support ring 26 is neoprene rubber, while the material of the sealing support ring 27 is silicone. A pressure protrusion ring 29 is integrally disposed at the bottom of the pressure sealing ring 28. The swivel tube 16 is tightly wrapped by the sealing support ring 26 and the sealing support ring 27 and slides in conjunction with the pressure sealing ring 28. A load-bearing screw 30 is uniformly screwed circumferentially onto the pressure sealing plate 25 and located on the outer edge of the sealing mounting hole. One end of the load-bearing screw 30 passes through the pressure sealing ring 28 and is locked by a locking nut 31.

[0049] When the locking nut 31 locks the load-bearing screw 30, the pressure ring 29 is pressed into the sealing support ring 27, causing the sealing support ring 27 to press downward and expand laterally. This allows the sealing support ring 26 and the sealing support ring 27 to seal and press against the inner wall of the sealing mounting hole and the outer edge of the rotating tube 16. With this setting, when the electric telescopic rod 27 drives the sealing plate 25 to move up and down, gas will not pass through the joint between the rotating tube 16 and the sealing ring 25.

[0050] The outer edge of the sealing plate 25 is vertically and evenly provided with an outer annular groove. The inner wall of the outer annular groove is bonded with resin adhesive to the outer sealing ring 32. The outer sealing ring 32 is made of rubber and is pressed and sealed to the inner wall of the mixing cylinder 1.

[0051] With this setup, when the pressure sealing plate 25 moves up and down driven by the electric telescopic rod 37, gas will not be allowed to pass through the joint between the pressure sealing plate 25 and the mixing cylinder 1.

[0052] Under the overall setup, the sealing plate 25 effectively separates the mixing cylinder 1 into a liquid mixing environment and a gas environment, which do not interfere with each other, thereby effectively preventing gas from being drawn in during the liquid mixing and stirring process.

[0053] The electric telescopic rod 37 is fixed to the right side of the inner top of the top cover 14 by bolts. The electric telescopic rod 37 is a stepper motor driven electric telescopic rod. The top rod of the electric telescopic rod 37 is fixed to the pressure sealing plate 25 by circumferential bolts.

[0054] Driven by the electric telescopic rod 37, the sealing plate 25 can move up and down in a closed manner within the mixing cylinder 1.

[0055] See Figure 1 and Figure 2 The liquid level control and discharge mechanism includes a discharge port 33 set on the pressure sealing plate 25. A flange is connected to a solenoid valve 34 at the top of the discharge port 33. The flange at the liquid inlet end of the solenoid valve 34 is connected to the lower end of the telescopic pipe 35. The flange at the upper end of the telescopic pipe 35 is connected to a circumferentially provided opening at the top of the top cover 14. The flange at the upper end of the opening is connected to a feed pipe 36. The flange at the feed pipe 36 is connected to the discharge end of an external metering pump. The pumping end of the metering pump is connected to the discharge end of an external defoaming machine. The inlet end of the defoaming machine is connected to the lower discharge end of an external pressurized tank through a pipe.

[0056] It is worth noting that the solenoid valve 34 opens first, and after that, the metering pump starts. After the metering pump operates, the top metering pump stops under control. When the preset liquid level is reached, the solenoid valve 34 closes.

[0057] See Figure 2 The bottom of the sealing plate 25 is sealed and fixed with a temperature sensor 40, which is used to detect the temperature of pharmaceutical excipients.

[0058] SeeFigure 1 , Figure 2 and Figure 8 The control mechanism includes a fixing rod 51 bolted to the right side of the mixing drum 1, and a control box 52 bolted to the right end of the fixing rod 51. The upper part of the control box 52 is fixed with an insulating pad screw to the development board 53. An integrated relay 54 and a driver group 55 are respectively installed in the control box 52 and located at the lower part of the development board 53. An industrial control computer 56 is installed on the panel of the control box 52.

[0059] The power control terminal of motor 15 is connected to the power control input terminal of peripheral servo controller via a cable. The main power of peripheral servo controller is connected to peripheral power via a cable. The power control terminal of electric telescopic rod 16 is connected to the power control input terminal of one driver in driver group 55 via a cable. The power control terminal of electric telescopic rod 27 is connected to the power control input terminal of another driver in driver group 55 via a cable. The main power input terminals of each driver in driver group are connected to peripheral power via cables. The power input terminal of pump 24, the potential terminal of solenoid valve 34, and the power control terminal of ultrasonic generator are connected to the terminal of integrated relay 54 via cables. The power input terminal of integrated relay is connected to peripheral power via a cable. The main power terminal of industrial computer 56 is connected to peripheral power via a cable.

[0060] In addition, the terminal block of the integrated relay 54 is also connected to the control terminal of the solenoid valve via a cable.

[0061] See Figure 9 The development board 53 includes a temperature signal receiving module, a pressure signal receiving module, a liquid level signal receiving module, and a relay signal receiving module. The transmission line of the temperature sensor 40 is connected to the signal input pin of the temperature signal receiving module, which is used to receive the temperature signal input from the temperature sensor 40 in real time. The signal line of the pressure sensor 38 is connected to the signal input pin of the pressure signal receiving module, which is used to receive the pressure signal input from the pressure sensor 38 in real time. The signal line of the liquid level gauge is connected to the signal input pin of the liquid level signal receiving module, which is used to receive the liquid level signal input from the liquid level gauge 39 in real time. The shared terminal of the ultrasonic generator's control panel is connected to the signal input pin of the relay signal receiving module via a transmission line, which is used to receive the process signals of the ultrasonic generator's operation in real time.

[0062] The temperature signal receiving module, air pressure signal receiving module, liquid level signal receiving module, and relay signal receiving module are connected to the signal analysis module. The signal analysis module is connected to the temperature control signal output module, relay signal control module 1, relay signal control module 2, relay signal control module 3, steering speed control module, steering speed control module 1, and steering speed control module 2.

[0063] The signal analysis module processes the real-time received temperature signal into temperature data, compares the processed temperature data with its set temperature action threshold, and issues a temperature control command to the temperature control signal output module based on the comparison result.

[0064] The signal output pin of the temperature control signal output module is connected to the control signal input terminal of the temperature controller via a signal line. The temperature action threshold is set to W. When the sealing plate 25 moves down to the set position and the temperature sensing end of the temperature sensor 40 is inserted into the liquid, the actual measured temperature value is R. When R > W, the temperature control signal output module sends a stop heating command to the temperature controller. When R = W, the temperature control signal output module sends a constant temperature control command to the temperature controller. When R < W, the temperature control signal output module sends a continuous heating command to the temperature controller.

[0065] The signal analysis module processes the real-time acquired air pressure and liquid level signals into air pressure data and liquid level data, and combines the processed air pressure data and liquid level data with its set standard liquid level data, stationary liquid level data and action air pressure data for analysis. It then sends a control command to the top air suction mechanism to the relay control input module 2, a lifting command to the top sealing mechanism to the steering speed control input module 1, and an on / off command to the liquid level control and discharge mechanism to the relay control input module 3. After the commands to control the top air suction mechanism, the top sealing mechanism and the liquid level control and discharge mechanism are completed, it sends a control command to the steering speed control input module to control the operation of the motor 15, and times the running time of the motor 15. When the preset stirring time is reached, it sends a control command to the steering speed control input module 2 to control the lifting and lowering operation of the plug discharge mechanism.

[0066] The standard liquid level data U includes U1, U2, U3, U4...Un, where U1 is the liquid level data after the first liquid is added according to the standard amount, U2 is the liquid level data after the second liquid is added according to the standard amount, and so on until the last liquid level data Un. The signal output pin of the relay control module three is connected to the control signal input terminal of the microcontroller unit of each metering pump through the signal line. When the signal analysis module receives the external metering instruction, it controls the solenoid valve 34 to open according to the feeding sequence, and sends the running instruction to the microcontroller unit of the metering pump according to the feeding sequence. When each standard liquid level data is reached, the corresponding solenoid valve 34 is closed by sending the corresponding signal control module three. After a delay of 8 seconds, the opening and closing control of the next solenoid valve 34 is executed until the last solenoid valve 34 changes from the open state to the closed state, and the liquid addition program is completed.

[0067] The operating air pressure data L must meet the following requirements: when the sealing plate 25 is not activated and vacuuming is performed, the space above the liquid in the mixing cylinder 1 is evacuated to an air pressure of 0.08 MPa.

[0068] The liquid level data P at the stop position must meet the following condition: the electric telescopic rod 37 drives the pressure sealing plate 25 to move down until the bottom of the pressure sealing plate 25 contacts the upper liquid surface of the mixed liquid in the mixing cylinder 1;

[0069] In addition, the signal analysis module also stores empty tank liquid level data K, which is the liquid level data obtained when the liquid material in the mixing cylinder 1 is effectively discharged when the pressure sealing plate 25 rises and resets.

[0070] The steering speed control module controls the speed of motor 15 at 1500 r / min.

[0071] The operating mode is as follows: After the liquid level control and discharge mechanism completes the addition of each type of liquid and all solenoid valves 34 are closed, it sends an operation command to the top air suction mechanism to the relay control module 2. The suction pump 24 runs until the air pressure value input by the air pressure sensor 38 is L. Then, it sends a stop operation command to the top air suction mechanism to the relay control module 2, and the suction pump 24 stops running and its port check valve closes. After a 5-second delay, it sends an extension command to the top sealing mechanism. The electric telescopic rod 27 extends and drives the pressure sealing plate 25 to move down until the real-time input liquid level data reaches P. Then, it sends a stop operation command to the top sealing mechanism, and the electric telescopic rod 27 stops moving. After a 3-second delay, it sends a control motor 15 operation command to the steering speed control module to time the motor 15 operation. When the preset stirring time is reached, it sends a reset command to the steering speed control module to control the motor 15. After a 5-second delay... The system sends a retraction command to the top sealing mechanism, causing the electric telescopic rod 37 to extend and move the sealing plate 25 upward to reset. After a 1-second delay, it sends a control command to the relay signal control module 2 to open the solenoid valve, allowing helium to enter the upper space of the mixing cylinder 1. After a 2-second delay, it sends a control command to the steering CNC module 2 to open the plugging mechanism, causing the electric telescopic rod 6 to extend and raise the discharge cylinder 8. The material guide hole 10 rises into the mixing cylinder 1, and the mixed liquid is discharged through the material guide hole 10 into the discharge cylinder 8 and into the discharge pipe 3. Under the action of the industrial pump, the mixed liquid is drawn into the finished product tank on the filling line. When the liquid level gauge 39 returns to K, it sends a control command to the relay signal control module 2 to close the solenoid valve and a control command to the steering CNC module 2 to close the plugging mechanism. The electric telescopic rod 6 retracts to its original position, and the discharge cylinder 8 retracts into the lower discharge pipe 4.

[0072] When the liquid level control and discharge mechanism is initially running, the signal analysis module sends an ultrasonic generator operation command to the relay signal control and transmission module, and after the lifting and lowering operation command of the plug mechanism is completed, it sends an ultrasonic generator stop operation command to the relay signal control and transmission module.

[0073] The signal analysis module is bidirectionally connected to the signal processing module, which in turn is bidirectionally connected to the mapping processing module. The signal processing module batch transfers the processing information from the signal analysis module to the mapping processing module, and the mapping processing module then constructs the processing information in real time into the signal receiving unit of the industrial computer 56. The preset parameters programmed into the industrial computer 56 are correspondingly programmed into the preset storage area of ​​the signal analysis module by the signal processing module.

[0074] With this setup, the industrial computer 56 can dynamically monitor the signal analysis module's processing, and can also issue running commands and input corresponding preset parameters to the signal analysis module.

[0075] The working principle of this embodiment is as follows:

[0076] The ultrasonic transducer 12, liquid level control and discharge mechanism, top sealing mechanism, and top air suction mechanism are used to control the amount of liquid added in batches. The top air suction mechanism removes the gas from the upper part of the liquid in the mixing cylinder 1. Combined with the ultrasonic vibration caused by the operation of the ultrasonic transducer 12, the gas originally present in the liquid is also effectively removed, thus forming a vacuum state. Then, the top sealing mechanism moves down to isolate the liquid in a space containing only the liquid. During stirring, this effectively avoids the presence of air bubbles in the liquid. Moreover, with this setup, there is no need for continuous vacuuming. In addition, during the stirring process, some small molecule effective components and water generated by the reaction between the liquids are retained, ensuring the quality of the auxiliary material output.

[0077] Pressure sensor 38, level gauge 39, temperature sensor 40, and control mechanism: The temperature sensor 40 obtains the actual liquid temperature value, and the control mechanism controls the heating coil 11 to heat the liquid based on the comparison with the action temperature threshold. The pressure signal and liquid level signal obtained by the pressure sensor 38 and level gauge 39 are used as comparison parameters to control the top air suction mechanism, top sealing mechanism, and liquid level control and discharge mechanism to operate alternately and orderly according to the set instructions. The system has a high degree of automation and is easy to use.

[0078] The above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention.

Claims

1. A high-efficiency mixing device for pharmaceutical excipients, comprising a mixing cylinder, support legs disposed on four sides of the bottom of the mixing cylinder, a mounting base disposed at the bottom of the support legs, a heating coil disposed in the inner cavity of the mixing cylinder, a lower drain pipe connected to the bottom of the mixing cylinder, and a drain pipe connected to the lower end of the lower drain pipe, characterized in that: The pipe is equipped with a plugging mechanism, which is used to seal the bottom of the mixing cylinder and discharge the mixed pharmaceutical excipients inside the mixing cylinder. The plugging mechanism includes a support plate disposed on one side of the upper part of the drain pipe, an electric telescopic rod disposed on the support plate, a connecting plate connected to the top rod of the electric telescopic rod, a drain cylinder slidably disposed inside the lower drain pipe, sealing rings disposed on the upper and lower parts of the drain cylinder, a guide hole uniformly disposed circumferentially on the upper part of the drain cylinder, a movable opening disposed on one side of the middle part of the lower drain pipe, and the connecting plate passing through the movable opening and connected to one side of the drain cylinder; An ultrasonic transducer is installed on the inner side wall of the mixing cylinder. A top cover is provided on the top of the mixing cylinder. A top cover is installed on the top of the top cover. A motor is installed on the top of the top cover. The rotor shaft of the motor passes through the top cover and is connected to a spiral tube. A connector is connected to the bottom of the spiral tube. An outer stirring frame and an inner stirring frame are installed on both sides of the connector. The inner wall of the mixing cylinder is equipped with a top sealing mechanism, which is used to control and adjust the upper space of the pharmaceutical excipients. The spiral tube is equipped with a top air suction mechanism, which is used to evacuate the space between the liquid level of the pharmaceutical excipients in the mixing cylinder and the top sealing mechanism. The top sealing mechanism is equipped with a liquid level control and discharge mechanism, which is used to control the amount of raw materials discharged into the inner cylinder of the mixing drum. The top sealing mechanism is equipped with a pressure sensor and a level gauge. The pressure sensor is used to measure the gas-liquid pressure between the liquid level of the pharmaceutical excipients in the mixing drum and the top sealing mechanism. The level gauge is used to detect the liquid level height of the pharmaceutical excipients in the mixing drum. A control mechanism is installed on one side of the mixing cylinder. The control mechanism is used to analyze the real-time liquid level signal input from the liquid level gauge and the real-time air pressure signal input from the air pressure sensor, and to control the lifting and lowering of the top sealing mechanism, the suction action of the top air suction mechanism, and the discharge and stop operation of the liquid level control and discharge mechanism. The operation of the plug discharge mechanism is controlled by calculating the stirring time.

2. The high-efficiency mixing device for pharmaceutical excipients according to claim 1, characterized in that: The top air suction mechanism includes suction holes evenly arranged circumferentially on the upper part of the spiral tube. Sealed bearings are provided on the spiral tube at both the upper and lower parts of the suction holes. A cover is provided on the sealed bearing. A drain pipe is provided on one side of the cover. One end of the drain pipe is connected to a suction pump. The top air suction mechanism also includes an inner support plate 1 disposed on the inner wall of the spiral tube. The inner support plate 1 has a plug hole, a pressure plug is pressed into the plug hole, and a soft sleeve is disposed on the pressure plug. A connecting rod is connected to the center of the lower end of the soft sleeve. The middle part of the spiral tube has uniformly arranged suction holes in a circumferential direction. The upper part of the connecting rod has uniformly arranged supporting connecting rods in a circumferential direction, and a movable sealing ring is installed on the outer side of the supporting connecting rod. The movable sealing ring seals the port of the suction hole. An inner support plate 2 is disposed inside the spiral tube and below the suction hole. One end of the connecting rod passes through the inner support plate 2 and is provided with a support plate. A spring is sleeved on the connecting rod, and the two ends of the spring are respectively supported by the inner support plate 2 and the support plate.

3. The high-efficiency mixing device for pharmaceutical excipients according to claim 2, characterized in that: The top sealing mechanism includes a pressure sealing plate slidably disposed inside the mixing cylinder and a sealing mounting hole disposed inside the pressure sealing plate. A sealing support ring one, a sealing support ring two, and a pressure sealing ring are respectively disposed from bottom to top in the sealing mounting hole. A pressure protrusion ring is disposed at the bottom of the pressure sealing ring. The spiral tube passes through the sealing support ring one, the sealing support ring two, and the pressure sealing ring. A load-bearing screw is uniformly connected circumferentially on the pressure sealing plate and located on the outer edge of the sealing mounting hole. One end of the load-bearing screw passes through the pressure sealing ring and is locked by a lock nut. An outer sealing ring is uniformly disposed vertically on the outer edge of the pressure sealing plate and the outer sealing ring is pressed against the inner wall of the mixing cylinder. The inner top of the top cover is provided with an electric telescopic rod two, and the top rod of the electric telescopic rod two is connected to the pressure sealing plate.

4. The high-efficiency mixing device for pharmaceutical excipients according to claim 3, characterized in that: The liquid level control and discharge mechanism includes a discharge port on the pressure sealing plate. A solenoid valve is connected to the top of the discharge port. The liquid inlet end of the solenoid valve is connected to a telescopic pipe, and the upper end of the telescopic pipe is connected to a circumferentially provided opening on the top of the top cover. One end of the opening is connected to an external pressurized material tank through a feed pipe.

5. The high-efficiency mixing device for pharmaceutical excipients according to claim 4, characterized in that: A temperature sensor is installed at the bottom of the sealing plate, and the temperature sensor is used to detect the temperature of the pharmaceutical excipients.

6. The high-efficiency mixing device for pharmaceutical excipients according to any one of claims 1-5, characterized in that: The control mechanism includes a fixed rod connected to one side of the mixing drum. One end of the fixed rod is connected to a control box. A development board is installed in the upper part of the control box. An integrated relay and a driver assembly are installed in the control box and located in the lower part of the development board. An industrial computer is installed on the panel of the control box.

7. The high-efficiency mixing device for pharmaceutical excipients according to claim 6, characterized in that: The development board includes a temperature signal receiving module, a pressure signal receiving module, a liquid level signal receiving module, and a relay signal receiving module. The temperature signal receiving module is used to receive the temperature signal input in real time from the temperature sensor. The pressure signal receiving module is used to receive the pressure signal input in real time from the pressure sensor. The liquid level signal receiving module is used to receive the liquid level signal input in real time from the liquid level gauge. The relay signal receiving module is used to receive the process signals of the ultrasonic generator in real time. The temperature signal receiving module, air pressure signal receiving module, liquid level signal receiving module, and relay signal receiving module are connected to a signal analysis module. The signal analysis module is connected to a temperature control signal output module, relay signal control input module one, relay signal control input module two, relay signal control input module three, steering speed control input module, steering speed control input module one, and steering speed control input module two. The signal analysis module processes the real-time received temperature signal into temperature data and compares the processed temperature data with its set temperature action threshold. Based on the comparison result, it issues a temperature control command to the temperature control signal output module. The signal analysis module also processes the real-time acquired air pressure and liquid level signals into air pressure data. Based on the data and liquid level data, the processed air pressure data and liquid level data are combined with their set standard liquid level data, stationary liquid level data, and action air pressure data for analysis. Then, a control command is sent to the relay control input module 2 to control the top air suction mechanism to perform suction, a control command is sent to the steering speed control input module 1 to control the top sealing mechanism to lift, and a control command is sent to the relay control input module 3 to control the liquid level control and discharge mechanism to turn on and off. After the control commands for the top air suction mechanism, top sealing mechanism, and liquid level control and discharge mechanism are completed, a control command is sent to the steering speed control input module to control the motor to run, and the motor running time is timed. When the preset stirring time is reached, a control command is sent to the steering speed control input module 2 to control the lifting and lowering of the plug discharge mechanism. When the liquid level control and discharge mechanism is initially running, the signal analysis module sends an ultrasonic generator operation command to the relay signal control and transmission module, and after the lifting and lowering operation command of the plug mechanism is completed, it sends an ultrasonic generator stop operation command to the relay signal control and transmission module. The signal analysis module is bidirectionally connected to the signal processing module, and the signal processing module is bidirectionally connected to the mapping processing module. The signal processing module transfers the processing information from the signal analysis module to the mapping processing module in batches, and the mapping processing module constructs the processing information into the signal receiving unit of the industrial control computer in real time. The preset parameters programmed into the industrial control computer are correspondingly programmed into the preset storage area of ​​the signal analysis module by the signal processing module.

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