Granulation method of Yiqing granules

Abstract

The invention discloses a Yiqing granule granulation method which comprises the following steps: step 1, taking a coptis chinensis extract, a scutellaria baicalensis extract and a rheum officinale extract, separately heating to 60-70 DEG C, and sequentially transferring into a liquid spraying trolley after heating; step 2, preparing base powder, and adding the base powder into a boiling granulator; 3, heating and mixing the base powder, and after the base powder is heated to a set temperature and the mixing time reaches a set time, spraying the rheum officinale extract, the scutellaria baicalensis extract and the coptis chinensis extract into the base powder in sequence; 4, after all the extractum is sprayed, continuously drying, and discharging; step 5, carrying out size stabilization and total mixing on the dried particles; and step 6, feeding the granules after total mixing into a sub-packaging workshop to carry out granule packaging, and then carrying out external packaging through an external packaging workshop. The production process is simplified, the process links are obviously reduced, the yield is obviously improved, the granulation is uniform, the product quality is stable, and the production efficiency is greatly improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical manufacturing technology, specifically to a method for granulating Yiqing granules. Background Technology

[0002] Yiqing Granules are a commonly used traditional Chinese medicine with the effects of clearing heat and purging fire, detoxifying, cooling blood and stopping bleeding. Currently, most granulation methods use wet granulation. The granulation process is as follows: Coptis chinensis extract, rhubarb extract, and Scutellaria baicalensis extract are dried separately in a spray drying room and then pulverized in a pulverizing workshop. After each material is pulverized, the fine powder is collected, passed through an 80-mesh or larger sieve, and transferred to the weighing room. The corresponding quantity and number of portions are weighed according to the "Weighing Segments" specified in the "Material Weighing Segmentation Summary Table". Each package is labeled accordingly and transferred to the material temporary storage room. The pulverizing room and pulverizer are cleaned until there is no residue left from pulverizing the material and the residue is measured.

[0003] Then, wet granulation is performed. One part rhubarb extract powder, one part scutellaria baicalensis extract powder, one part coptis chinensis extract powder, one part sucrose powder, and one part dextrin are added to a high-efficiency wet granulator. Low-speed stirring and cutting are started. 75% ethanol is added, and high-speed stirring and cutting are performed until uniform. The material is then discharged. The wet-granulated material is added to a vibrating granulator and granulated through an 18-mesh sieve. The granules are then placed in a stainless steel drum. The material obtained from the vibrating granulator is transferred to a spray granulation dryer for drying. The dried granules are bagged, weighed, labeled, sealed, and sent to an intermediate station or the next process. The yield calculated using this method is:

[0004] Yield = Actual particle weight / Theoretical particle weight × 100%. Between 85.0% and 90.0%.

[0005] However, this method involves numerous steps, complex processes, and high requirements for parameter control. This increases production costs, reduces production efficiency, and the use of wet granulation results in uneven particle size and unstable product quality, with a final yield of only 85.0% to 90.0%, which is low. Summary of the Invention

[0006] This invention aims to solve the technical problems existing in the prior art, and innovatively proposes a one-stage granulation method, which simplifies the production process, significantly reduces the number of steps, significantly improves the yield, produces uniform granulation, stabilizes product quality, and greatly improves production efficiency.

[0007] To achieve the above-mentioned objectives of this invention, this invention provides a method for granulating granules, comprising the following steps:

[0008] Step 1: Take Coptis chinensis extract, Scutellaria baicalensis extract and Rheum palmatum extract, and heat them separately to 60-70℃. After heating, transfer them into the spraying cart in sequence.

[0009] Step 2: Prepare the base powder and add it to the fluidized bed granulator;

[0010] Step 3: Heat and mix the base powder. After the base powder is heated to the set temperature and mixed for the set time, spray rhubarb extract, scutellaria extract, and coptis extract into the base powder in sequence.

[0011] Step 4: After all the extract has been sprayed, continue drying and discharge the material;

[0012] Step 5: Granulate and mix the dried granules. During granulation, use 10-mesh and 60-mesh sieves to screen twice, and select granules with a pore size smaller than 10 mesh and larger than 60 mesh for mixing.

[0013] Step 6: After the total mixing is completed, the granules are sent to the packaging workshop for granule packaging, and then to the outer packaging workshop for outer packaging.

[0014] Calculate dry pellet yield and material balance:

[0015] Yield = Actual particle weight / Theoretical particle weight × 100%, and in this invention it is 95.0% to 100.0%.

[0016] In the above scheme: In step 3, the heating temperature of the base powder is 75-90℃, and the mixing time is 15-30 minutes.

[0017] In the above scheme: In step 3, when spraying the extract, the spray pressure is 0.2-0.6 MPa and the spray frequency is 25-35 Hz.

[0018] In the above scheme: In step 3, the bag is shaken while the extract is sprayed out, and each shaking lasts for 10 to 20 seconds, with an interval of 150 to 190 seconds between shaking.

[0019] In the above scheme: In step 4, the drying time is 15 min to 20 min.

[0020] In the above scheme: the base powder is made of dextrin and sucrose, and the sucrose is first pulverized in a pulverizing workshop before being prepared.

[0021] In the above scheme, the mass ratio of dextrin to sucrose is 1-1.5:2.

[0022] In summary, due to the adoption of the above technical solution, the beneficial effects of this invention are as follows: By heating the rhubarb extract, scutellaria extract, and coptis extract to 60-70℃, maintaining their fluidity, the extracts are directly sprayed into the base powder in a fluidized bed granulator, eliminating the need for drying and pulverizing the extracts, thus simplifying the production process and significantly reducing steps. During the spraying of the extracts, the base powder is intermittently shaken to ensure uniform absorption of the extracts, resulting in uniform granulation. Using the method of this invention, the yield of purified granules can reach 95.0%–100.0%. The yield is significantly improved, the granulation is uniform, the product quality is stable, and production efficiency is greatly enhanced. Attached Figure Description

[0023] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0024] Figure 1 This is a flowchart of the granulation method for granulation of granules according to the present invention. Detailed Implementation

[0025] Example 1

[0026] like Figure 1 As shown, a method for granulating granules includes the following steps:

[0027] Step 1: Take Coptis chinensis extract, Scutellaria baicalensis extract and Rheum palmatum extract, and heat them separately to the set temperature. After heating, transfer them into the spraying cart in sequence. The heating temperature is 60-70℃.

[0028] Step 2: Prepare the base powder according to the ratio and add the base powder to the fluidized bed granulator; the base powder is made of dextrin and sucrose, and the sucrose is pulverized in the pulverizing workshop before preparation, and the mass ratio of dextrin to sucrose in this embodiment is 1:2;

[0029] Step 3: Heat and mix the base powder. After heating the base powder to a temperature of 75-90℃, mix it for 15-30 minutes. After mixing, spray rhubarb extract, scutellaria baicalensis extract, and coptis chinensis extract into the base powder in sequence according to the spray conditions of 0.2-0.6 MPa pressure and 25-35 Hz spray frequency, and shake the bag intermittently. Each shaking time is 10-20 seconds, and the interval between shaking times is 150-190 seconds.

[0030] Step 4: After all the extract has been sprayed, continue drying for another 15 to 20 minutes before discharging.

[0031] Step 5: Granulate and mix the dried granules. During granulation, use 10-mesh and 60-mesh sieves to screen twice, and select granules with a pore size smaller than 10 mesh and larger than 60 mesh for mixing.

[0032] Step 6: After the total mixing is completed, the granules are sent to the packaging workshop for granule packaging, and then to the outer packaging workshop for outer packaging.

[0033] Example 2

[0034] A method for granulating granules includes the following steps:

[0035] Step 1: Take Coptis chinensis extract, Scutellaria baicalensis extract and Rheum palmatum extract, and heat them separately to the set temperature. After heating, transfer them into the spraying cart in sequence. The heating temperature is 60-70℃.

[0036] Step 2: Prepare the base powder according to the ratio and add it to the fluidized bed granulator; the base powder is made of dextrin and sucrose, and the sucrose is pulverized in the pulverizing workshop before preparation, and the mass ratio of dextrin to sucrose in this embodiment is 1.5:2;

[0037] Step 3: Heat and mix the base powder. After heating the base powder to a temperature of 75-90℃, mix it for 15-30 minutes. After mixing, spray rhubarb extract, scutellaria baicalensis extract, and coptis chinensis extract into the base powder in sequence according to the spray conditions of 0.2-0.6 MPa pressure and 25-35 Hz spray frequency, and shake the bag intermittently. Each shaking time is 10-20 seconds, and the interval between shaking times is 150-190 seconds.

[0038] Step 4: After all the extract has been sprayed, continue drying for another 15 to 20 minutes before discharging.

[0039] Step 5: Granulate and mix the dried granules. During granulation, use 10-mesh and 60-mesh sieves to screen twice, and select granules with a pore size smaller than 10 mesh and larger than 60 mesh for mixing.

[0040] Step 6: After the total mixing is completed, the granules are sent to the packaging workshop for granule packaging, and then to the outer packaging workshop for outer packaging.

Claims

1. A method for granulating granules, characterized in that: Includes the following steps: Step 1: Take Coptis chinensis extract, Scutellaria baicalensis extract and Rheum palmatum extract, and heat them separately to 60-70℃. After heating, transfer them into the spraying cart in sequence. Step 2: Prepare the base powder and add it to the fluidized bed granulator; Step 3: Heat and mix the base powder. After the base powder is heated to the set temperature and mixed for the set time, spray rhubarb extract, scutellaria extract, and coptis extract into the base powder in sequence. Step 4: After all the extract has been sprayed, continue drying and discharge the material; Step 5: Granulate and mix the dried granules. During granulation, use 10-mesh and 60-mesh sieves to screen twice, and select granules with a pore size smaller than 10 mesh and larger than 60 mesh for mixing. Step 6: After the total mixing is completed, the granules are sent to the packaging workshop for granule packaging, and then to the outer packaging workshop for outer packaging.

2. The method for granulating granules according to claim 1, characterized in that: In step 3, the heating temperature of the base powder is 75-90℃, and the mixing time is 15-30 minutes.

3. The method for granulating granules according to claim 2, characterized in that: In step 3, when spraying the extract, the spray pressure is 0.2-0.6 MPa and the spray frequency is 25-35 Hz.

4. The method for granulating granules according to claim 3, characterized in that: In step 3, the bag is shaken while the extract is being sprayed out. Each shaking lasts for 10 to 20 seconds, and the interval between shaking is 150 to 190 seconds.

5. The method for granulating granules according to claim 1, characterized in that: In step 4, the drying time is 15 min to 20 min.

6. The method for granulating granules according to claim 1, characterized in that: The base powder is made from dextrin and sucrose, and the sucrose is first pulverized in a pulverizing workshop before being prepared.

7. The method for granulating granules according to claim 1, characterized in that: The mass ratio of dextrin to sucrose is 1-1.5:2.

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