Anti-inflammatory and bacteriostatic traditional Chinese medicine composition and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses an anti-inflammatory and bacteriostatic traditional Chinese medicine composition and a preparation method thereof. The anti-inflammatory and bacteriostatic traditional Chinese medicine composition is prepared from the following raw materials: 15 to 20 parts of herba portulacae, 10 to 15 parts of honeysuckle flower, 3 to 5 parts of fresh ginger extract, 5 to 9 parts of liquorice root extract, 5 to 10 parts of herba taraxaci, 8 to 12 parts of herba violae, 3 to 6 parts of radix scutellariae and 5 to 10 parts of radix sophorae flavescentis. The maximum diameters of inhibition zones of the traditional Chinese medicine composition for escherichia coli, staphylococcus aureus and pseudomonas viridicola are 29.95 mm, 27.75 mm and 16.00 mm respectively, the traditional Chinese medicine composition has a high antibacterial effect, the swelling inhibition degree of the traditional Chinese medicine composition is 74.25-82.56, and the traditional Chinese medicine composition has a high anti-inflammatory effect.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine technology, and more specifically, to an anti-inflammatory and antibacterial traditional Chinese medicine composition and its preparation method. Background Technology

[0002] Inflammation is a defensive response of the body to various damaging factors such as infection, physical injury, or chemical irritation. However, excessive inflammation can damage the body and easily lead to other diseases, manifesting as redness, swelling, heat, and pain. While Western medicine can quickly reduce inflammation, long-term use can easily cause side effects such as gastrointestinal damage and immunosuppression. In contrast, traditional Chinese medicine combinations have the advantages of fewer toxic side effects, no drug residues, and no drug resistance. Through the combination of various ingredients, they can not only reduce inflammation but also improve the overall condition of the body and reduce the side effects of drugs.

[0003] In related technologies, ingredients such as Coptis chinensis and Phellodendron chinense, which have antibacterial effects against Staphylococcus aureus and Escherichia coli, are added to traditional Chinese medicine compositions to achieve anti-inflammatory and antibacterial effects. However, berberine in Coptis chinensis and Phellodendron chinense may inhibit the balance of intestinal flora with long-term use in large doses, and the anti-inflammatory and antibacterial effects are weak, making it difficult to meet the actual use needs. Summary of the Invention

[0004] In order to improve the anti-inflammatory and antibacterial effects of traditional Chinese medicine compositions, this application provides an anti-inflammatory and antibacterial traditional Chinese medicine composition and its preparation method.

[0005] In a first aspect, this application provides an anti-inflammatory and antibacterial traditional Chinese medicine composition, which adopts the following technical solution: An anti-inflammatory and antibacterial traditional Chinese medicine composition comprising the following raw materials in parts by weight: purslane 15-20 parts, honeysuckle 10-15 parts, ginger extract 3-5 parts, licorice extract 5-10 parts, dandelion 5-10 parts, viola yedoensis 8-12 parts, baicalin 3-6 parts, and sophora flavescens 5-10 parts.

[0006] By employing the above-mentioned technical solutions, purslane contains flavonoids, alkaloids, organic acids, polysaccharides, volatile oils, and other components, exhibiting multiple effects such as antioxidation, antibacterial, anti-inflammatory, and anti-allergic properties. Honeysuckle can inhibit the production and release of inflammatory factors, as well as the activity of inducible cyclooxygenase, relieving congestion and edema at the site of inflammation. It also disrupts the survival and proliferation of microorganisms at multiple targets, damaging the cell membrane and cell wall structure of microorganisms, thus playing an antibacterial role. Furthermore, honeysuckle also regulates the function of immune cells and has the effects of clearing heat and detoxifying, promoting blood circulation, and reducing inflammation.

[0007] Gingerol in ginger extract can stimulate blood circulation in the gastrointestinal mucosa, enhance intestinal peristalsis, accelerate the contact between drug components and intestinal mucosa, and promote the absorption of traditional Chinese medicine composition. Ginger extract also has fat solubility and forms complexes with chlorogenic acid in honeysuckle and flavonoids in purslane, which improves solubility.

[0008] Glycyrrhizic acid in licorice extract promotes the solubility and dispersibility of luteolin from honeysuckle, flavonoids from purslane, and baicalin from scutellaria in the aqueous environment of the gastrointestinal tract. It can also form a protective layer on the surface of matrine components, preventing the active ingredients from being destroyed by gastric acid and digestive enzymes. Furthermore, licorice extract can regulate the intestinal environment, increase mucosal permeability, and promote the absorption of traditional Chinese medicine compositions.

[0009] When ginger extract and licorice extract are added simultaneously, the glycyrrhizic acid in the licorice extract can increase the solubility of gingerol in the ginger extract in an aqueous environment, reducing the degradation of gingerol caused by oxidation or high temperature. Meanwhile, gingerol can mildly dilate local blood vessels, enhance blood circulation in inflamed or infected areas, and promote the absorption of glycyrrhizic acid, thereby synergistically improving the body's absorption of the traditional Chinese medicine composition.

[0010] Dandelion contains flavonoids, which reduce the synthesis and release of downstream pro-inflammatory factors and inflammatory mediators, thus exerting an anti-inflammatory effect. The terpenoids and flavonoids in Viola yedoensis can act on bacterial cell membranes, causing bacterial death due to osmotic pressure imbalance, inhibiting bacterial metabolism and proliferation, thereby exerting an antibacterial effect. Scutellaria baicalensis reduces inflammatory responses such as redness, swelling, and fever caused by bacterial infections by inhibiting the release of inflammatory factors. The main extract of Sophora flavescens is alkaloids, which disrupt the structure of bacterial cell walls and cell membranes; this component has a significant antibacterial effect against Escherichia coli and Staphylococcus aureus.

[0011] This application utilizes the synergistic effect of active ingredients in a traditional Chinese medicine composition to significantly inhibit the growth of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, thereby exhibiting significant anti-inflammatory and antibacterial effects. It can be applied to products such as lotions, toothpaste, mouthwash, cosmetics, and external wound medicine preparations.

[0012] As a preferred embodiment: an anti-inflammatory and antibacterial traditional Chinese medicine composition comprising the following raw materials in parts by weight: 17-19 parts of purslane, 12-14 parts of honeysuckle, 3.5-4.5 parts of ginger extract, 6-9 parts of licorice extract, 7-9 parts of dandelion, 9-11 parts of violet, 4-5 parts of scutellaria, and 7-9 parts of sophora flavescens.

[0013] The anti-inflammatory and antibacterial traditional Chinese medicine composition of this application uses 17-19 parts of purslane, 12-14 parts of honeysuckle, 3.5-4.5 parts of ginger extract, 6-9 parts of licorice extract, 7-9 parts of dandelion, 9-11 parts of violet, 4-5 parts of scutellaria, and 7-9 parts of sophora flavescens. The properties of the traditional Chinese medicine composition are all predictable, and all have high anti-inflammatory and antibacterial effects.

[0014] Preferably, the weight ratio of the ginger extract to the licorice extract is 1:(1.5-2.5).

[0015] By adopting the above scheme and adjusting the weight ratio of ginger extract to licorice extract, the absorption of the traditional Chinese medicine composition by the human body can be further enhanced, thereby improving the anti-inflammatory and antibacterial effects of the traditional Chinese medicine composition.

[0016] Preferably, the ginger extract is prepared by the following steps: Select fresh, mold-free ginger, remove impurities and moisture, pulverize into 20-40 mesh ginger particles, add to 1-butyl-3-methylimidazolium hexafluorophosphate, heat in a water bath at 40-60℃, reflux extract 2-3 times, each time for 1.5-2 hours, collect the extract, perform ultrasonic-assisted extraction, filter, concentrate under reduced pressure, and spray dry to obtain the ginger extract.

[0017] By adopting the above scheme and using 1-butyl-3-methylimidazolium hexafluorophosphate to extract ginger extract, the solubility is higher, thus improving the extraction rate. Moreover, the decomposition temperature of 1-butyl-3-methylimidazolium hexafluorophosphate is higher than that of ethanol solution, exhibiting outstanding chemical and thermal stability. In addition, 1-butyl-3-methylimidazolium hexafluorophosphate does not chemically react with phenolic and terpene components in ginger, avoiding the destruction of active ingredients by traditional acidic or alkaline solvents and improving the extraction effect.

[0018] Preferably, the mass-to-volume ratio of the ginger granules to 1-butyl-3-methylimidazolium hexafluorophosphate is 1:(5-10).

[0019] By adopting the above scheme and adjusting the mass-volume ratio of ginger granules to 1-butyl-3-methylimidazolium hexafluorophosphate, the extraction rate can be further improved, thereby enhancing the anti-inflammatory and antibacterial effects of the traditional Chinese medicine composition.

[0020] Preferably, the licorice extract is prepared by the following steps: Select dried licorice roots and rhizomes, remove impurities, drain water, pulverize into 20-40 mesh licorice particles, dry in an oven at 60-80℃ for 2-4 hours, enzymatically hydrolyze with cellulase at 50℃ and pH 5-6 for 30 minutes, add to a 30-80% ethanol aqueous solution, add citric acid to adjust the pH to 5-6, and extract with ultrasonic assistance at 60-70℃. Then add to a 60-80% ethanol aqueous solution, add vitamin C, and extract with ultrasonic assistance at 60-70℃. Filter and concentrate, then spray dry to obtain the licorice extract.

[0021] The amount of cellulase used is 1-3% of the weight of the licorice granules; the amount of vitamin C used is 0.5-1% of the weight of the licorice granules.

[0022] By employing the above method, licorice granules are first enzymatically hydrolyzed with cellulase at 50℃ and pH 5-6 for 30 minutes to disrupt the cell wall structure of the licorice granules. This promotes the contact of active ingredients such as glycyrrhizic acid and flavonoids in the ethanol aqueous solution, increasing the dissolution rate, shortening the extraction time, and reducing the amount of ethanol aqueous solution used. Then, licorice granules are added to a 30-50% concentration ethanol aqueous solution for ultrasonic-assisted extraction of glycyrrhizic acid and flavonoids in a weakly acidic environment. Next, fat-soluble components are extracted using a 60-80% concentration ethanol aqueous solution to improve the solubility of Sophora flavescens and other raw materials. Vitamin C is added to inhibit the oxidative degradation of active ingredients, maintain their activity, protect the stability of the flavonoid structure, and further enhance the anti-inflammatory and antibacterial effects of the traditional Chinese medicine composition.

[0023] Preferably, the mass-to-volume ratio of the licorice granules to the 30-80% concentration ethanol aqueous solution is 1:(12-15); the mass-to-volume ratio of the licorice granules to the 60-80% concentration ethanol aqueous solution is 1:(8-10).

[0024] By adopting the above scheme, adjusting the mass-volume ratio of licorice granules to a 30-80% concentration ethanol aqueous solution facilitates the extraction of active ingredients such as glycyrrhizic acid and flavonoids from the licorice granules, thereby increasing the extraction rate. Adjusting the mass-volume ratio of licorice granules to a 60-80% concentration ethanol aqueous solution promotes the extraction of fat-soluble components and improves the solubility of other raw materials such as Sophora flavescens, thereby further enhancing the anti-inflammatory and antibacterial effects of the traditional Chinese medicine composition.

[0025] Secondly, this application provides a method for preparing any of the above-mentioned anti-inflammatory and antibacterial traditional Chinese medicine compositions, which is specifically achieved through the following technical solution: A method for preparing an anti-inflammatory and antibacterial traditional Chinese medicine composition includes the following steps: pulverizing and mixing raw materials except for ginger extract and licorice extract, soaking in water, decocting, filtering the decoction, adding ginger extract and licorice extract, cooling, alcohol precipitation, standing, concentrating or drying to obtain the traditional Chinese medicine composition.

[0026] In summary, this application includes at least one of the following beneficial technical effects: 1. This application, through the types and dosages of each raw material in the traditional Chinese medicine composition, enables the traditional Chinese medicine composition to exhibit high antibacterial effects against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, with inhibition zone diameters of 27.81-28.12 mm, 26.43-26.58 mm, and 14.28-14.79 mm, respectively.

[0027] 2. This application improves the antibacterial effect of a traditional Chinese medicine composition by preparing ginger extract in the composition and controlling the mass-to-volume ratio of ginger granules to 1-butyl-3-methylimidazolium hexafluorophosphate to be 1:(5-10). This results in inhibition zone diameters of 29.37-29.58 mm, 27.35-27.41 mm, and 15.21-15.36 mm for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, respectively.

[0028] 3. This application improves the antibacterial effect of the traditional Chinese medicine composition by preparing licorice extract in the traditional Chinese medicine composition and controlling the mass-volume ratio of licorice granules to 30-80% ethanol aqueous solution to be 1:(12-15) and the mass-volume ratio of licorice granules to 60-80% ethanol aqueous solution to be 1:(8-10). This results in the inhibition zone diameters of the traditional Chinese medicine composition against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa being 29.81-29.95 mm, 27.62-27.75 mm, and 15.81-16.00 mm, respectively.

[0029] 4. The swelling inhibition degree of the traditional Chinese medicine composition obtained in this application is 74.25-82.56, which shows a high anti-inflammatory effect. Detailed Implementation

[0030] The following detailed description, in conjunction with specific embodiments, further illustrates this application. All the raw materials used in this application are commercially available products and are intended to fully disclose the raw materials used in this application; they should not be construed as limiting the source of the raw materials. Specifically: purslane, from Shandong; honeysuckle, from Pingyi, Shandong; dandelion, from Shandong; violet, from Hebei; scutellaria, from Chengde, Hebei; and sophora flavescens, from Yi County, Hebei.

[0031] The following is an example of the preparation of ginger extract: Preparation Example 1 The ginger extract of Example 1 was prepared by the following steps: 1 kg of fresh, mold-free ginger was selected, impurities and moisture were removed, and the ginger was crushed into 20-40 mesh ginger particles. The ginger particles were added to 4 L of 1-butyl-3-methylimidazolium hexafluorophosphate, heated in a water bath at 65°C, and refluxed for 3 times, 1.5 h each time. The extract was collected, and ultrasonic extraction was performed. The extract was then filtered, concentrated under reduced pressure, and spray-dried to obtain the ginger extract.

[0032] Preparation Examples 2-5 The ginger extracts prepared in Examples 2-5 were identical to those prepared in Example 1 in terms of raw material types and preparation methods. The difference was in the amount of 1-butyl-3-methylimidazolium hexafluorophosphate added, specifically 5L, 8L, 10L, and 11L. The other raw material types and amounts were the same as those in Example 1.

[0033] Preparation Example 6 The licorice extract of Example 6 was prepared by the following steps: 1 kg of dried licorice root and rhizome were selected, impurities were removed and water was drained, and the licorice particles were pulverized into 20-40 mesh licorice particles. The particles were dried in an oven at 70°C for 3 hours, enzymatically hydrolyzed with 20 g of cellulase at 50°C and pH 5 for 30 minutes, added to 11 L of 40% ethanol aqueous solution, and citric acid was added to adjust the pH to 5-6. The extraction was carried out by ultrasonic-assisted heating at 65°C. The extract was then added to 7 L of 70% ethanol aqueous solution, 8 g of vitamin C was added, and the extraction was carried out by ultrasonic-assisted heating at 65°C. The extract was then filtered, concentrated, and spray-dried to obtain the licorice extract.

[0034] Preparation Examples 7-10 The licorice extracts prepared in Examples 7-10 were identical to those prepared in Example 6 in terms of raw material types and preparation methods. The difference lay in the different amounts of 30-80% and 60-80% ethanol aqueous solutions, specifically 12L and 8L, 14L and 9L, 15L and 10L, and 16L and 11L, respectively. The other raw material types and amounts were the same as those in Example 6.

[0035] Example 1 The anti-inflammatory and antibacterial traditional Chinese medicine composition of Example 1 was prepared by the following steps: According to the dosage in Table 1, the raw materials except for ginger extract and licorice extract were crushed and mixed, then soaked in 20 times the amount of water, and decocted 3 times. The first decoction was 1 hour, the second decoction was 1.5 hours, and the third decoction was 0.5 hours. The decoction was filtered, and ginger extract and licorice extract were added and mixed. The mixture was cooled, precipitated with alcohol, allowed to stand, concentrated or dried to obtain the traditional Chinese medicine composition.

[0036] Among them, ginger extract, water-soluble ginger extract powder, was purchased from Hebei Rencan Biotechnology Co., Ltd., with a mesh size of 80 mesh; licorice extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., with an extraction ratio of 10:1 and a mesh size of 80 mesh.

[0037] Examples 2-5 The anti-inflammatory and antibacterial traditional Chinese medicine compositions in Examples 2-5 are prepared in the same way as those in Example 1, and the types of raw materials are the same. The difference lies in the dosage of each raw material, as detailed in Table 1.

[0038] Table 1. Dosage of each raw material in the anti-inflammatory and antibacterial traditional Chinese medicine compositions of Examples 1-5 (unit: kg) raw material Example 1 Example 2 Example 3 Example 4 Example 5 purslane 18 18 18 18 18 honeysuckle 13 13 13 13 13 ginger extract 5 4 4 4 3 Licorice extract 5 6 8 10 9 Dandelion 8 8 8 8 8 Viola yedoensis 10 10 10 10 10 Scutellaria baicalensis 5 5 5 5 5 Sophora flavescens 8 8 8 8 8 Examples 6-10 The anti-inflammatory and antibacterial traditional Chinese medicine compositions in Examples 6-10 are the same as those in Example 3, except that the ginger extract used is the ginger extract prepared in Examples 1-5, and the other raw materials and dosages are the same as those in Example 3.

[0039] Examples 11-15 The anti-inflammatory and antibacterial traditional Chinese medicine compositions in Examples 11-15 are the same as those in Example 8, except that the licorice extract used is the licorice extract prepared in Examples 6-10, and the other raw materials and dosages are the same as those in Example 8.

[0040] Comparative Example 1 The anti-inflammatory and antibacterial traditional Chinese medicine composition of Comparative Example 1 was prepared in the same way as that of Example 1, except that ginger extract in the raw materials of the traditional Chinese medicine composition was replaced with licorice extract in equal amounts, and the remaining raw materials and dosages were the same as those of Example 1.

[0041] Comparative Example 2 The anti-inflammatory and antibacterial traditional Chinese medicine composition of Comparative Example 2 was prepared in the same way as that of Example 1, except that the licorice extract in the raw materials of the traditional Chinese medicine composition was replaced with ginger extract in equal amounts, and the remaining raw materials and dosages were the same as those in Example 1.

[0042] Performance Testing (Part 1) The performance of the traditional Chinese medicine compositions obtained in different Examples 1-15 and Comparative Examples 1-2 was tested using the following methods. The test results are shown in Table 2.

[0043] Antibacterial effect: The traditional Chinese medicine compositions obtained in Examples 1-15 and Comparative Examples 1-2 were mixed with sterile water to obtain a traditional Chinese medicine composition preparation with a concentration of 25 μg / mL. Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were prepared into bacterial suspensions with a concentration of 107 CFU / mL. 15 mL of LB agar medium and 0.15 mL of bacterial suspension were added to a petri dish and mixed quickly. After the medium solidified, 100 μL of the drug composition preparation was added. 25 μg / mL ampicillin was used as a control. The petri dish was placed in a constant temperature incubator at 37℃ for 24 h and the results were observed. The diameter of the inhibition zone was measured with vernier calipers.

[0044] Table 2 Performance test results of different traditional Chinese medicine compositions The performance test results of the traditional Chinese medicine composition in Table 2 show that the traditional Chinese medicine composition prepared in this application has a maximum inhibition zone diameter of 29.95 mm, 27.75 mm and 16.00 mm against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, respectively, and has a high antibacterial effect.

[0045] Based on the performance testing of the traditional Chinese medicine compositions in Examples 1-5, it was found that the inhibition zone diameters of the traditional Chinese medicine compositions in Examples 2-3 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were 27.81-28.12 mm, 26.43-26.58 mm, and 14.28-14.79 mm, respectively, which were higher than those in Examples 1 and 5. This indicates that the raw material dosage of the traditional Chinese medicine compositions in Examples 2-4 was more appropriate, which improved the antibacterial effect of the traditional Chinese medicine compositions.

[0046] Based on the performance testing of the traditional Chinese medicine compositions in Examples 6-10, it was found that the inhibition zone diameters of the traditional Chinese medicine compositions in Examples 7-9 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were 29.37-29.58 mm, 27.35-27.41 mm, and 15.21-15.36 mm, respectively, which were higher than those in Examples 6 and 10. This indicates that a mass-to-volume ratio of ginger granules to 1-butyl-3-methylimidazolium hexafluorophosphate of 1:(5-10) was more suitable when preparing ginger extract in the traditional Chinese medicine compositions, which further improved the antibacterial effect of the traditional Chinese medicine compositions.

[0047] Based on the performance testing of the traditional Chinese medicine compositions in Examples 11-15, it was found that the inhibition zone diameters of the traditional Chinese medicine compositions in Examples 12-14 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were 29.81-29.95 mm, 27.62-27.75 mm, and 15.81-16.00 mm, respectively, which were higher than those in Examples 11 and 15. This indicates that the mass-to-volume ratio of licorice granules to 30-80% ethanol aqueous solution in the preparation of licorice extract in the traditional Chinese medicine composition was 1:(12-15), and the mass-to-volume ratio of licorice granules to 60-80% ethanol aqueous solution was 1:(8-10), which improved the antibacterial effect of the traditional Chinese medicine composition.

[0048] Based on the performance test data of Example 1 and Comparative Examples 1-2, it was found that adding ginger extract and licorice extract to the traditional Chinese medicine composition can improve the antibacterial effect of the traditional Chinese medicine composition to varying degrees.

[0049] Performance Testing (Part 2) The performance of the traditional Chinese medicine compositions obtained in different Examples 1, 3, 8, 13 and Comparative Examples 1-2 were tested using the following methods. The test results are shown in Table 3.

[0050] Fifty-six Kunming mice were randomly divided into nine groups of eight mice each (half male and half female), weighing 18-22g each. Vaseline (0.1g / mouse, negative control) and a traditional Chinese medicine composition (0.05g / mouse) were applied to the right auricle of each group, respectively. The mice were administered the medication twice daily, housed individually, and kept in single cages for seven consecutive days. The mice were fasted for 12 hours before the last administration. Forty-five minutes after administration, 20μL of xylene was applied to the right ear of each mouse. Twenty minutes later, ear pieces were taken from the same location using a 6mm diameter punch. The ears were weighed using a balance with a weight of 0.01%, and the difference in weight between the two ear pieces was used as the degree of auricular swelling. The swelling inhibition rate was calculated as: (Swelling degree of negative control group - Swelling degree of sample) / Swelling degree of negative control group. Table 3 shows the performance test results of different traditional Chinese medicine compositions. Swelling inhibition Example 1 74.25 Example 3 76.49 Example 8 80.12 Example 13 82.56 Comparative Example 1 67.65 Comparative Example 2 64.31 The performance test results of the traditional Chinese medicine composition in Table 3 show that the swelling inhibition degree of the traditional Chinese medicine composition prepared in this application is 74.25-82.56, indicating a high anti-inflammatory effect.

[0051] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A traditional Chinese medicine composition with anti-inflammatory and antibacterial properties, characterized in that, It includes the following ingredients in parts by weight: purslane 15-20 parts, honeysuckle 10-15 parts, ginger extract 3-5 parts, licorice extract 5-10 parts, dandelion 5-10 parts, violet 8-12 parts, scutellaria baicalensis 3-6 parts, and sophora flavescens 5-10 parts.

2. The anti-inflammatory and antibacterial traditional Chinese medicine composition according to claim 1, characterized in that, It includes the following ingredients in parts by weight: purslane 17-19 parts, honeysuckle 12-14 parts, ginger extract 3.5-4.5 parts, licorice extract 6-9 parts, dandelion 7-9 parts, violet 9-11 parts, scutellaria baicalensis 4-5 parts, and sophora flavescens 7-9 parts.

3. The anti-inflammatory and antibacterial traditional Chinese medicine composition according to claim 1, characterized in that, The weight ratio of the ginger extract to the licorice extract is 1:(1.5-2.5).

4. The anti-inflammatory and antibacterial traditional Chinese medicine composition according to claim 1, characterized in that, The ginger extract is prepared by the following steps: Select fresh, mold-free ginger, remove impurities and moisture, pulverize into 20-40 mesh ginger particles, add to 1-butyl-3-methylimidazolium hexafluorophosphate, heat in a water bath at 60-70℃, reflux extract 2-3 times, each time for 1.5-2 hours, collect the extract, perform ultrasonic-assisted extraction, filter, concentrate under reduced pressure, and spray dry to obtain the ginger extract.

5. The anti-inflammatory and antibacterial traditional Chinese medicine composition according to claim 4, characterized in that, The mass-to-volume ratio of the ginger granules to 1-butyl-3-methylimidazolium hexafluorophosphate is 1:(5-10).

6. The anti-inflammatory and antibacterial traditional Chinese medicine composition according to claim 1, characterized in that, The licorice extract is prepared through the following steps: Select dried licorice roots and rhizomes, remove impurities, drain water, and pulverize into 20-40 mesh licorice particles. Dry in an oven at 60-80℃ for 2-4 hours. Enzymatically hydrolyze with cellulase at 50℃ and pH 5-6 for 30 minutes. Add to a 30-50% ethanol aqueous solution, add citric acid to adjust the pH to 5-6, and extract with ultrasound-assisted heating at 60-70℃. Then add to a 60-80% ethanol aqueous solution, add vitamin C, and extract with ultrasound-assisted heating at 60-70℃. Filter and concentrate, then spray dry to obtain the licorice extract.

7. The anti-inflammatory and antibacterial traditional Chinese medicine composition according to claim 6, characterized in that, The mass-to-volume ratio of the licorice granules to the 30-80% concentration ethanol aqueous solution is 1:(12-15); the mass-to-volume ratio of the licorice granules to the 60-80% concentration ethanol aqueous solution is 1:(8-10).

8. A method for preparing an anti-inflammatory and antibacterial traditional Chinese medicine composition according to any one of claims 1-7, characterized in that, The process includes the following steps: pulverize and mix the raw materials except for ginger extract and licorice extract, soak them in water, decoct them, filter the decoction, add ginger extract and licorice extract, mix them, cool them, precipitate them with alcohol, let them stand, concentrate or dry them to obtain the traditional Chinese medicine composition.

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