Automatic cooling method for fluidized drying granulator

Abstract

The invention discloses an automatic cooling method for a fluidized drying granulator. The automatic cooling method comprises the following steps: S1, building an intelligent temperature control granulation system; s2, the air inlet humidity is set, and air dehumidification is conducted; s3, setting a granulation temperature, and starting boiling granulation; s4, the drying temperature is set, air heating is conducted, and the materials are dried for t1 min; s5, the air inlet system stops air heating, air dehumidification is kept, and the materials are cooled for t2 minutes; s6, setting a discharging temperature, and performing discharging judgment: when the material temperature is less than or equal to a discharging temperature set value, entering S7; when the material temperature is smaller than or equal to the discharging temperature set value, returning to S5; and S7, shutdown is conducted, and materials are output. The method has the beneficial effects that the temperature of the finished medicine particles is reduced, the finished medicine particles are prevented from absorbing moisture and caking, it is guaranteed that the quality of the finished medicine particles meets the production requirement, the rework rate and the rejection rate of the finished medicine particles are reduced, and the production cost is reduced.

Description

Technical Field

[0001] This invention relates to the field of fluidized bed drying granulation technology, and in particular to an automatic cooling method for a fluidized bed drying granulator. Background Technology

[0002] A vertical fluidized bed granulator is a pharmaceutical-grade device used to manufacture drug granules. Drug powder is loaded into a fluidized bed. Air, purified and heated by an air handling system, enters the fluidized bed and carries the drug powder through a fluidized boiling motion. This suspends the drug powder within the fluidized bed, where it combines with binder droplets sprayed from an atomizer to form granules. The air needs to be heated during granulation and drying, resulting in high temperatures for the finished drug granules. Directly outputting the finished drug granules exposes them to room temperature, causing moisture absorption and clumping.

[0003] Disadvantages of existing technology: Direct output of finished drug granules at excessively high temperatures will cause the finished drug granules to clump together, leading to rework or scrapping of the finished drug granules, thereby increasing production costs, and making it inconvenient for packaging and storage. Summary of the Invention

[0004] The purpose of this invention is to provide an automatic cooling method for a fluidized bed dryer granulator, which can reduce the temperature of the finished drug granules, prevent the finished drug granules from absorbing moisture and clumping together, ensure that the quality of the finished drug granules meets production requirements, and reduce the production cost of drug granules.

[0005] An automatic cooling method for a fluidized bed dryer granulator, the key of which includes the following steps:

[0006] It includes the following steps,

[0007] S1. Construct an intelligent temperature control particle system: The intelligent temperature control particle system includes a fluidized bed, which is connected to an air inlet system and a main fan. The air inlet system supplies the fluidized bed with air for heating and boiling, and air for cooling and boiling.

[0008] S2. Set the intake humidity. The intake system determines the intake humidity in real time according to the set intake humidity value and performs air dehumidification.

[0009] S3. Set the granulation temperature. The air inlet system heats the air according to the set granulation temperature value and delivers the air for heating and boiling into the fluidized bed to start fluidized granulation.

[0010] S4. Set the drying temperature. The air intake system heats the air according to the set drying temperature value and conveys the air for heating and boiling into the fluidized bed to dry the material for t1 minutes.

[0011] S5. The air intake system stops air heating, maintains air dehumidification, and conveys cooling and boiling air into the fluidized bed to cool the material for t2 minutes.

[0012] S6. Set the discharge temperature. The fluidized bed will perform a discharge determination every t3 minutes based on the set discharge temperature.

[0013] When the material temperature is less than or equal to the discharge temperature setpoint, proceed to S7;

[0014] If the material temperature is slightly higher than the discharge temperature setpoint, return to S5;

[0015] S7. Stop the machine and output materials.

[0016] The above method can cool down the finished drug particles in the fluidized bed, prevent the finished drug particles from absorbing moisture and clumping together after being discharged, reduce the rework rate and scrap rate of finished drug particles, and reduce the production cost of drug particles.

[0017] Further description: In S1, the fluidized bed body is provided with a base, a fluidized bed, a granulation chamber and a collection chamber from bottom to top; the base is connected to the air outlet of the air inlet system through an air inlet pipe, and the air inlet pipe is equipped with an air inlet temperature sensor and an air inlet volume regulating valve; the fluidized bed is equipped with a material temperature sensor; the collection chamber is connected to the main blower through an air outlet pipe.

[0018] An ambient humidity sensor is installed at the air inlet of the air intake system. The air intake system is arranged in the order of air treatment, including a dehumidification zone and a heating zone. The dehumidification zone is equipped with a surface cooler and a mist separator. A vertical baffle is installed between the surface cooler and the mist separator. An air outlet is opened on the vertical baffle and is connected to the inlet of the mist separator. The surface cooler is equipped with a condensate regulating valve.

[0019] The heating zone is divided into a cold air passage and a hot air passage by a horizontal baffle. A heat exchanger is installed in the hot air passage, and a steam proportional regulating valve is installed in the heat exchanger. A cold and hot air mixing valve is installed at the outlet of the heating zone. The cold and hot air mixing valve is used to control the opening or closing of the cold air passage and the hot air passage. A valve actuator is installed in the cold and hot air mixing valve.

[0020] The outlet of the mist separator is connected to the inlet of the cold air channel and the inlet of the hot air channel via a Y-shaped pipe. The cold air channel is used to deliver air for cooling and boiling, and the hot air channel is used to deliver air for heating and boiling. An air humidity sensor is installed on the Y-shaped pipe.

[0021] Further description: the material temperature sensor, the inlet air temperature sensor, the ambient humidity sensor, and the inlet air humidity sensor are respectively connected to the first input terminal, the second input terminal, the third input terminal, and the fourth input terminal of the PLC;

[0022] The main fan, air intake regulating valve, condensate regulating valve, steam proportional regulating valve, and valve driver are respectively connected to the first control terminal, second control terminal, third control terminal, fourth control terminal, and fifth control terminal of the PLC.

[0023] All of the above sensors and valves are connected to the PLC. The PLC automatically controls the valve action based on humidity and temperature information, thereby achieving automatic cooling of the finished drug granules, improving cooling efficiency, and freeing up manpower.

[0024] Further described, in S2, the ambient humidity sensor detects the air humidity and sends it to the PLC via the third input terminal. The PLC determines the intake air humidity. When the air humidity is less than or equal to the intake air humidity setpoint, the PLC does not generate a control signal; when the air humidity is greater than the intake air humidity setpoint, the PLC generates a dehumidification control signal. Based on the dehumidification control signal, the PLC opens the condensate regulating valve via the third control terminal, causing the surface cooler to condense and dehumidify the air, and further dries the air in conjunction with the mist separator, outputting cooling and boiling air.

[0025] The intake air humidity setting is 30-50%RH.

[0026] Normal temperature air enters the air intake system and comes into full contact with the surface of the cooling coil. The water vapor in the air condenses into small water droplets upon encountering the cold air and, combined with the mist separator, achieves air-water separation, thereby reducing air humidity and temperature.

[0027] Further described, in S5, the PLC closes the steam proportional regulating valve through the fourth control terminal to stop air heating, and controls the valve driver to open the cold air channel through the fifth control terminal. The cooling and boiling air is then introduced into the fluidized bed through the cold air channel to drive the material to boil and cool the material.

[0028] The value of t2 is 2 minutes, and the main fan maintains full-frequency operation.

[0029] To further describe, while the cold air duct is open, the PLC adjusts the opening of the air intake regulating valve through the second control terminal to reduce the air intake velocity.

[0030] When cooling materials, the large temperature difference between the air and the materials, and the excessive humidity of the air, will increase the risk of material agglomeration. Therefore, it is necessary to introduce dry and cold air into the fluidized bed to reduce the risk of material agglomeration.

[0031] Further described, in S6, the material sensor detects the material temperature every t3 minutes and sends the material temperature to the PLC for discharge determination;

[0032] When the material temperature is less than or equal to the discharge temperature set value, the PLC generates a shutdown control signal and enters S7;

[0033] When the material temperature is greater than the discharge temperature set value, the PLC generates a cooling control signal and returns to S5;

[0034] The discharge temperature is set to room temperature, t3 is set to 2 minutes, and the main blower operates at full frequency.

[0035] The PLC performs comprehensive calculations based on the real-time material temperature data collected by the material temperature sensor, automatically controls each device, and generates data curves to achieve traceable cooling.

[0036] Further description: In S7, the PLC controls the main fan to stop running and the air intake regulating valve to close through the first control terminal and the second control terminal, so that the material in the fluidized bed stops boiling and outputs the material.

[0037] Beneficial effects: This invention reduces the temperature of finished drug granules, prevents them from absorbing moisture and clumping together, ensures that the quality of finished drug granules meets production requirements, reduces the rework rate and scrap rate of finished drug granules, and lowers production costs. Attached Figure Description

[0038] Figure 1 This is a flowchart of the present invention;

[0039] Figure 2 This is a schematic diagram of the cooling system of the present invention;

[0040] Figure 3 This is a schematic diagram of the PLC connection for the present invention. Detailed Implementation

[0041] The specific embodiments and working principles of the present invention will be further described in detail below with reference to the accompanying drawings.

[0042] like Figures 1-3 As shown, an automatic cooling method for a fluidized bed dryer granulator includes the following steps:

[0043] S1. Construct an intelligent temperature control particle system: The intelligent temperature control particle system includes a fluidized bed 1, which is connected to an air inlet system 3 and a main fan 5. The air inlet system 3 supplies the fluidized bed 1 with air for heating and boiling and air for cooling and boiling.

[0044] The fluidized bed body 1 is provided with a base 1-1, a fluidized bed 1-2, a granulation chamber 1-3, and a collection chamber 1-4 arranged sequentially from bottom to top; the base 1-1 is connected to the air outlet of the air inlet system 3 through an air inlet pipe 2, and the air inlet pipe 2 is equipped with an air inlet temperature sensor 2-2 and an air inlet volume regulating valve 2-1; the fluidized bed 1-2 is equipped with a material temperature sensor 1-5; the collection chamber 1-4 is connected to the main blower 5 through an air outlet pipe 4;

[0045] An ambient humidity sensor 3-1 is installed at the air inlet of the air intake system 3. The air intake system 3 is provided with a dehumidification zone and a heating zone in the order of air treatment. The dehumidification zone is provided with a surface cooler 3-2 and a mist separator 3-5. A vertical baffle 3-4 is provided between the surface cooler 3-2 and the mist separator 3-5. An air outlet is opened on the vertical baffle 3-4, which is connected to the inlet of the mist separator 3-5. A condensate regulating valve 3-3 is installed on the surface cooler 3-2.

[0046] The heating zone is divided into a cold air passage 3-9 and a hot air passage 3-10 by a transverse baffle 3-8. A heat exchanger 3-11 is installed in the hot air passage 3-10, and a steam proportional regulating valve 3-12 is installed in the heat exchanger 3-11. A cold and hot air mixing valve 3-13 is installed at the outlet of the heating zone. The cold and hot air mixing valve 3-13 is used to control the opening or closing of the cold air passage 3-9 and the hot air passage 3-10. A valve actuator 3-14 is installed in the cold and hot air mixing valve 3-13.

[0047] The outlet of the mist separator 3-5 is connected to the inlet of the cold air channel 3-9 and the inlet of the hot air channel 3-10 through the Y-shaped pipe 3-6 respectively. The cold air channel 3-9 is used to transport air for cooling and boiling, and the hot air channel 3-10 is used to transport air for heating and boiling. An air inlet humidity sensor 3-7 is installed on the Y-shaped pipe 3-6.

[0048] The material temperature sensor 1-5, the air inlet temperature sensor 2-1, the ambient humidity sensor, and the air inlet humidity sensor 2-1 are respectively connected to the first input terminal, the second input terminal, the third input terminal, and the fourth input terminal of the PLC;

[0049] The main fan 5, air intake regulating valve 2-2, condensate regulating valve 3-3, steam proportional regulating valve 3-12, and valve actuator 3-14 are respectively connected to the first control terminal, second control terminal, third control terminal, fourth control terminal, and fifth control terminal of the PLC.

[0050] S2. Dehumidify the air: Set the intake humidity to 40%RH;

[0051] The ambient humidity sensor detects the air humidity and sends it to the PLC via the third input terminal. The PLC determines the intake air humidity. When the air humidity is less than or equal to 40% RH, the PLC does not generate a control signal; when the air humidity is greater than 40% RH, the PLC generates a dehumidification control signal. Based on the dehumidification control signal, the PLC opens the condensate regulating valve 3-3 via the third control terminal, causing the surface cooler 3-2 to condense and dehumidify the air, and further dries the air in conjunction with the mist separator 3-5, outputting cooling and boiling air with a humidity of less than or equal to 40% RH.

[0052] S3. Start boiling granulation: Set the granulation temperature to 40℃;

[0053] The PLC controls the opening of the steam proportional regulating valve 3-12 through the fourth control, thereby starting the heat exchanger 3-11 to heat the cooling and boiling air to obtain the heating and boiling air. The PLC also controls the valve driver 3-14 to open the hot air channel 3-10 through the fifth control terminal, so that the heating and boiling air is input into the fluidized bed 1-2 through the hot air channel 3-10 to drive the material to boil and start the stage granulation.

[0054] During the fluidized bed granulation process, the main blower 5 gradually increases its operating frequency as the granulation stage progresses, and after reaching full frequency, it maintains full frequency operation.

[0055] S4. Dry the material: Set the drying temperature to 55℃;

[0056] The PLC increases the opening of the steam proportional regulating valve 3-12 through the fourth control, thereby improving the heating effect of the heat exchanger 3-11 and increasing the temperature of the heating and boiling air. The hot air channel 3-10 is kept open, and the heating and boiling air at a higher temperature is input into the fluidized bed 1-2 to drive the material to boil and to dry the material for 5 minutes.

[0057] During the material drying process, the main fan 5 operates at full frequency.

[0058] S5. Cooling the material: The PLC closes the steam proportional regulating valve 3-12 through the fourth control terminal to stop air heating, and controls the valve driver 3-14 to open the cold air channel 3-9 through the fifth control terminal. The cooling and boiling air is introduced into the fluidized bed 1-2 through the cold air channel 3-9 to drive the material to boil and cool the material for 2 minutes.

[0059] While the cold air duct 3-9 is open, the PLC adjusts the opening of the air intake regulating valve 2-2 through the second control terminal to reduce the air intake speed;

[0060] During the material cooling process, the main fan 5 maintains full-frequency operation.

[0061] S6. Perform discharge determination: Set the discharge temperature to room temperature;

[0062] The material sensors 1-5 detect the material temperature every 2 minutes and send the material temperature to the PLC; when the material temperature is less than or equal to room temperature, the PLC generates a shutdown control signal and enters S7; when the material temperature is greater than room temperature, the PLC generates a cooling control signal and returns to S5.

[0063] During the material discharge judgment process, the main fan 5 maintains full-frequency operation.

[0064] S7. Shutdown and material output: The PLC controls the main fan 5 to stop running and the air intake regulating valve 2-2 to close through the first control terminal and the second control terminal. The material in the fluidized bed 1-2 stops boiling and outputs the material.

Claims

1. An automatic cooling method for a fluidized bed dryer granulator, characterized in that, It includes the following steps, S1. Build an intelligent temperature control particle system: The intelligent temperature control particle system includes a fluidized bed (1), which is connected to the air inlet system (3) and the main fan (5) respectively. The air inlet system (3) supplies the fluidized bed (1) with air for heating and boiling and air for cooling and boiling. S2. Set the intake humidity. The intake system (3) determines the intake humidity in real time according to the set intake humidity value and performs air dehumidification. S3. Set the granulation temperature. The air inlet system (3) heats the air according to the granulation temperature setting value and delivers the air for heating and boiling into the fluidized bed (1) to start boiling granulation. S4. Set the drying temperature. The air inlet system (3) heats the air according to the set drying temperature value and conveys the air for heating and boiling into the fluidized bed (1) to dry the material for t1 minutes. S5. The air intake system (3) stops air heating, maintains air dehumidification, and transports cooling and boiling air into the fluidized bed (1) to cool the material for t2 minutes. S6. Set the discharge temperature. The fluidized bed (1) performs a discharge determination every t3 minutes according to the set discharge temperature. When the material temperature is less than or equal to the discharge temperature setpoint, proceed to S7; If the material temperature is slightly higher than the discharge temperature setpoint, return to S5; S7. Stop the machine and output materials.

2. The automatic cooling method for a fluidized bed dryer granulator according to claim 1, characterized in that, In S1, the fluidized bed body (1) is provided with a base (1-1), a fluidized bed (1-2), a granulation chamber (1-3), and a collection chamber (1-4) from bottom to top; the base (1-1) is connected to the air outlet of the air inlet system (3) through an air inlet pipe (2), and the air inlet pipe (2) is equipped with an air inlet temperature sensor (2-2) and an air inlet volume regulating valve (2-1); the fluidized bed (1-2) is equipped with a material temperature sensor (1-5); the collection chamber (1-4) is connected to the main blower (5) through an air outlet pipe (4); An ambient humidity sensor (3-1) is installed at the air inlet of the air intake system (3); the air intake system (3) is provided with a dehumidification zone and a heating zone in the order of air treatment. The dehumidification zone is provided with a surface cooler (3-2) and a mist separator (3-5). A vertical baffle (3-4) is provided between the surface cooler (3-2) and the mist separator (3-5). An air outlet is opened on the vertical baffle (3-4) and the air outlet is connected to the inlet of the mist separator (3-5). The surface cooler (3-2) is equipped with a condensate regulating valve (3-3). The heating zone is divided into a cold air passage (3-9) and a hot air passage (3-10) by a transverse baffle (3-8). A heat exchanger (3-11) is installed in the hot air passage (3-10), and a steam proportional regulating valve (3-12) is installed in the heat exchanger (3-11). A hot and cold air mixing valve (3-13) is installed at the outlet of the heating zone. The hot and cold air mixing valve (3-13) is used to control the opening or closing of the cold air passage (3-9) and the hot air passage (3-10). A valve actuator (3-14) is installed in the hot and cold air mixing valve (3-13). The outlet of the mist separator (3-5) is connected to the inlet of the cold air channel (3-9) and the inlet of the hot air channel (3-10) through a Y-shaped pipe (3-6). The cold air channel (3-9) is used to transport air for cooling and boiling, and the hot air channel (3-10) is used to transport air for heating and boiling. An air inlet humidity sensor (3-7) is installed on the Y-shaped pipe (3-6).

3. The automatic cooling method for a fluidized bed dryer granulator according to claim 2, characterized in that, The material temperature sensor (1-5), the air inlet temperature sensor (2-1), the ambient humidity sensor, and the air inlet humidity sensor (2-1) are respectively connected to the first input terminal, the second input terminal, the third input terminal, and the fourth input terminal of the PLC; The main fan (5), air intake regulating valve (2-2), condensate regulating valve (3-3), steam proportional regulating valve (3-12), and valve actuator (3-14) are respectively connected to the first control terminal, second control terminal, third control terminal, fourth control terminal, and fifth control terminal of the PLC.

4. The automatic cooling method for a fluidized bed dryer granulator according to claim 3, characterized in that, In S2, the ambient humidity sensor detects the air humidity and sends it to the PLC via the third input terminal. The PLC determines the intake air humidity. When the air humidity is less than or equal to the intake air humidity setpoint, the PLC does not generate a control signal. When the air humidity is greater than the intake air humidity setpoint, the PLC generates a dehumidification control signal. Based on the dehumidification control signal, the PLC opens the condensate regulating valve (3-3) via the third control terminal, causing the surface cooler (3-2) to condense and dehumidify the air. Combined with the mist separator (3-5), the air is further dried, and cooling and boiling air is output. The intake air humidity setting is 30-50%RH.

5. The automatic cooling method for a fluidized bed dryer granulator according to claim 3, characterized in that, In S5, the PLC closes the steam proportional regulating valve (3-12) through the fourth control terminal to stop air heating, and controls the valve driver (3-14) through the fifth control terminal to open the cold air channel (3-9). The cooling and boiling air is input into the fluidized bed (1-2) through the cold air channel (3-9) to drive the material to boil and cool the material. The value of t2 is 2 minutes, and the main fan (5) maintains full-frequency operation.

6. The automatic cooling method for a fluidized bed dryer granulator according to claim 5, characterized in that, While the cold air duct (3-9) is open, the PLC adjusts the opening of the air intake regulating valve (2-2) through the second control terminal to reduce the air intake speed.

7. The automatic cooling method for a fluidized bed dryer granulator according to claim 3, characterized in that, In S6, the material sensor (1-5) detects the material temperature every t3 minutes and sends the material temperature to the PLC for discharge determination; When the material temperature is less than or equal to the discharge temperature set value, the PLC generates a shutdown control signal and enters S7; When the material temperature is greater than the discharge temperature set value, the PLC generates a cooling control signal and returns to S5; The discharge temperature is set to room temperature, t3 is set to 2 minutes, and the main blower (5) is kept running at full frequency.

8. The automatic cooling method for a fluidized bed dryer granulator according to claim 3, characterized in that... In S7, the PLC controls the main fan (5) to stop running and the air intake regulating valve (2-2) to close through the first control terminal and the second control terminal. The material in the fluidized bed (1-2) stops boiling and outputs the material.

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