A sampling and detection device

Abstract

This invention discloses a sampling and testing device, comprising a clamp body, a handle, a movable blade holder, a sample collection container, and a cutting head. The cutting head includes a blade and a connector, the connector being fixed to the end of the blade. The end of the connector has an annular drug storage chamber with its opening facing the blade. A drug storage and release structure is provided within the annular drug storage chamber. A squeezing element is also slidably mounted on the connector, and an elastic pre-tightening element is provided between the squeezing element and the connector. This sampling and testing device, through a single handle drive source and ingenious mechanical structure design, highly integrates multiple functional units such as cutting, sampling, transfer, and drug administration, achieving multi-functional synchronous coordination under a continuous mechanical action. The animal's ear itself acts as a mechanical transmission medium, automatically triggering the drug administration mechanism during the movement after sampling. This ensures that the timing, location, and triggering conditions of drug release form an inherent and inevitable mechanical linkage and closed-loop feedback with the sampling action.

Description

Technical Field

[0001] This invention relates to the field of sampling and testing technology, and more specifically, to a sampling and testing device. Background Technology

[0002] In livestock breeding, obtaining live tissue samples from livestock ears for DNA analysis is a crucial technique for assessing their genetic potential. However, traditional sampling devices (such as ear taggers or biopsy forceps) have many inherent limitations, severely restricting the efficiency of sampling operations and the reliability of sample quality.

[0003] First, traditional devices are single-function, separating sampling from subsequent processing. After cutting and collecting the sample, the operator must remove it from the instrument by hand or with auxiliary tools (such as tweezers) and transfer it to a storage container. This process significantly prolongs the sample's exposure to the external environment, greatly increasing the risk of contamination from the operator's gloves, airborne dust, and other pollutants. Cross-contamination and degradation of the sample can directly lead to deviations or even failures in subsequent gene sequencing or analysis results.

[0004] Secondly, the aforementioned sample transfer operations are not only cumbersome and time-consuming, reducing the efficiency of large-scale population sampling, but also cause secondary mechanical damage to the samples themselves, further affecting the accuracy of the analysis.

[0005] Furthermore, in pursuit of sampling efficiency, traditional procedures often omit anesthesia, leading to severe stress responses in animals during sampling (such as struggling and vocalizations). This vigorous movement actually increases the difficulty of the procedure, easily causing problems such as sampling location deviation and inconsistent sampling depth, resulting in non-standard sample specifications. Simultaneously, physiological changes triggered by pain stress may also affect the initial quality of the sample at the molecular level. Postoperative pain can also affect animal feed intake and growth, causing economic losses for farmers. Summary of the Invention

[0006] The purpose of this invention is to provide a sampling and detection device to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A sampling and detection device, comprising:

[0009] The clamp body includes an upper clamp arm and a lower clamp arm, the surface of the upper clamp arm has a first slot, and the upper clamp arm has a guide structure along its length direction;

[0010] The handle is hinged to the clamp body;

[0011] The movable tool holder is mounted on the guide structure of the upper clamp arm and is rotatably connected to the handle;

[0012] A sample collection container is detachably mounted on the front end of the upper clamp arm;

[0013] The cutting head is detachably mounted on the movable blade holder and includes a blade and a connector. The connector is fixed to the end of the blade and has an annular drug storage chamber at the end of the connector. The opening of the annular drug storage chamber faces the blade. A drug storage and release structure is provided inside the annular drug storage chamber. A pressing member is also slidably disposed on the connector and an elastic pre-tightening member is provided between the pressing member and the connector.

[0014] When the handle drives the movable blade holder to move toward the sample collection container, the movable blade holder drives the cutting head to perform cutting and sampling, and the obtained sample is contained in the sample collection container. During the sampling process, when the extruder is squeezed by the tissue around the sample, it can compress the elastic pre-tightening member and apply pressure to the drug storage and release structure, so that the drug is released from the opening of the annular drug storage chamber to the sampling area.

[0015] Preferably, the guide structure comprises a through groove at the end of the upper clamp arm and a limiting groove on the surface of the upper clamp arm. The movable tool holder is slidably connected in the through groove. The movable tool holder and the handle are rotatably connected by a limiting post. A first groove is provided on the surface of the handle. The limiting post is slidably connected in both the limiting groove and the first groove.

[0016] Preferably, a second slot is provided at the end of the upper clamp arm away from the guide structure, and a container seat is slidably connected in the second slot, with the sample collection container snapped into the container seat.

[0017] Preferably, a rubber pad is fixedly connected to the inner wall of the connector.

[0018] Preferably, the extrusion component includes a drive plate, a driven plate, and a slider. The driven plate has multiple flow grooves facing the cutter. The slider is fixed between the drive plate and the driven plate. The driven plate is located inside the annular drug storage chamber, and the drive plate is located outside the annular drug storage chamber. The elastic preload is fixed between the drive plate and the connector.

[0019] Preferably, the outer wall of the cutting tool is provided with a flow guide groove, one end of which is connected to the opening area of ​​the annular drug storage chamber, and the other end of which extends toward the free end of the cutting tool.

[0020] Preferably, the drug storage and release structure is a biodegradable sealing film containing the drug liquid, and the end of the extruder facing the drug storage and release structure has a puncture member, which punctures the sealing film when the extruder is pressed and moves.

[0021] Preferably, the puncture component includes a central needle and a plurality of expanding rods surrounding the central needle, the expanding rods having a bent portion, and the angle between the free end of the expanding rod and the central needle being an acute angle.

[0022] Preferably, the outer wall of the expanding rod has protrusions and through holes, and the protrusions and through holes are arranged at intervals along the axial direction of the expanding rod.

[0023] Preferably, the drug storage and release structure is a porous adsorbent material impregnated with drug solution.

[0024] By adopting the aforementioned technical solution, the beneficial effects of the present invention are:

[0025] 1. When the handle drives the movable blade holder to push the cutting head to cut and sample the animal's ear, the obtained sample tissue piece moves with the blade towards the sample collection container. During this process, the animal's ear itself, surrounding the sample tissue piece, acts as a trigger medium, naturally squeezing the extrusion component and overcoming the resistance of the elastic pre-tightening component, causing it to move towards the drug storage and release structure. This movement then triggers the drug storage and release structure, causing the drug liquid stored inside to be released instantly from the opening of the annular drug storage chamber under mechanical pressure. This achieves precise synchronization of the three functions of sampling, sample protection, and wound pretreatment, reducing the risk of bleeding and infection, while improving the sampling quality.

[0026] 2. Through a single handle drive source and ingenious mechanical structure design, multiple functional units, including cutting, sampling, transfer, and drug delivery, are highly integrated, achieving multi-functional synchronous coordination under a continuous mechanical action. The animal's ear itself serves as the mechanical transmission medium, automatically triggering the drug delivery mechanism during the movement after sampling. This ensures that the timing (instantaneously after cutting), location (the interface between the blade and the wound), and triggering condition (successful sample acquisition) of drug release are all intrinsically and inevitably linked to the sampling action, forming a closed-loop feedback mechanism.

[0027] 3. This integration produces a significant synergistic effect: complementary functions, that is, the drug delivery function directly serves the sampling function (reducing contamination and stabilizing animals), while the mechanical energy generated by the sampling action is directly used to trigger drug delivery, and the two support each other; multiplied effect, that is, the combination of cutting and immediate drug delivery not only completes physical sampling, but also creates a chemical environment conducive to sample preservation. Sampling and in-situ collection greatly reduce sample exposure and transfer links. Ultimately, the goal that previously required multiple independent steps was achieved in a very short time, and the overall effect (improvement in sample quality and operational efficiency) far exceeds the simple sum of the individual functions. Attached Figure Description

[0028] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments of the invention and, together with their description, serve to explain the principles of the invention.

[0029] Figure 1 This is a schematic diagram of the overall structure of the sampling and detection device in one embodiment;

[0030] Figure 2 This is a schematic diagram of a portion of the sampling and detection device in one embodiment;

[0031] Figure 3 This is a schematic diagram of the handle structure in one embodiment;

[0032] Figure 4 This is a schematic diagram of the movable tool holder structure in one embodiment;

[0033] Figure 5 This is a schematic diagram of the sample collection container and container seat structure in one embodiment;

[0034] Figure 6 This is a schematic diagram of the cutting head structure in one embodiment;

[0035] Figure 7 for Figure 6 Enlarged schematic diagram of the structure at point A in the diagram;

[0036] Figure 8 This is a schematic diagram of the extrusion component structure in one embodiment;

[0037] Figure 9 This is a schematic diagram of the connector structure in one embodiment;

[0038] Figure 10 This is a schematic diagram of the tool structure in one embodiment;

[0039] Figure 11 This is a schematic diagram of the puncture component structure in one embodiment;

[0040] Figure 12 This is a schematic diagram of the protective cover structure in one embodiment;

[0041] Figure label:

[0042] 100. Clamp body; 110. Upper clamp arm; 120. Lower clamp arm; 130. First slot; 140. Guide structure; 141. Through slot; 142. Limiting slot; 143. Limiting post; 150. Second slot; 160. Container base; 200. Handle; 210. First groove; 220. Second groove; 230. Pin; 240. Reset elastic element; 300. Movable blade holder; 310. Slide rod; 320. Clamping connector; 400. Sample collection container; 500. Cutting head; 501, protective cover; 502, third slot; 510, cutting tool; 520, connector; 530, annular drug storage chamber; 540, drug storage and release structure; 550, extrusion component; 551, drive plate; 552, driven plate; 553, slider; 554, flow channel; 560, elastic pre-tightening component; 570, rubber pad; 580, guide channel; 590, puncture component; 591, central puncture needle; 592, reaming rod; 593, protrusion; 594, through hole. Detailed Implementation

[0043] Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that, unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the invention.

[0044] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the invention or its application or use.

[0045] Techniques, methods, and equipment known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and equipment should be considered part of the specification.

[0046] In all the examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values.

[0047] like Figures 1-12 As shown, a sampling and testing device includes a clamp body 100, a handle 200, a movable blade holder 300, a sample collection container 400, and a cutting head 500.

[0048] Please refer to Figure 2 The clamp body 100 includes an upper clamp arm 110 and a lower clamp arm 120. The surface of the upper clamp arm 110 has a first slot 130 for placing livestock ears, and the upper clamp arm 110 has a guide structure 140 along its length.

[0049] For details, please refer to Figure 2The guide structure 140 consists of a through groove 141 at the end of the upper clamp arm 110 and a limiting groove 142 on the surface of the upper clamp arm 110. The movable tool holder 300 is slidably connected in the through groove 141. The limiting post 143 is hinged to the movable tool holder 300 on one hand and slidably connected in the first groove 210 on the surface of the handle 200 on the other hand. At the same time, the limiting post 143 slides along the limiting groove 142 of the upper clamp arm 110. This composite motion mechanism ensures accurate force transmission and smooth movement when the handle 200 drives the movable tool holder 300.

[0050] Please refer to Figure 2 and Figure 3 The handle 200 and the clamp body 100 are hinged at the middle by a pin 230. The surface of the handle 200 is provided with a second groove 220 for accommodating the upper clamp arm 110. A reset elastic element 240 is also fixedly connected between the handle 200 and the clamp body 100 for automatic reset of each component after sampling.

[0051] Please refer to Figure 2 and Figure 4 The movable tool holder 300 is disposed on the guide structure 140 of the upper clamp arm 110. Specifically, the movable tool holder 300 includes a slide rod 310 and a snap connector 320 fixed to the front end of the slide rod 310. The slide rod 310 and the handle 200 are hinged through the aforementioned limiting post 143.

[0052] Please refer to Figure 1 The sample collection container 400 is detachably mounted on the front end of the upper clamp arm 110 via the container base 160, which facilitates quick sample removal and container replacement, improving operational convenience. The sample collection container 400 contains DNA sample preservation solution.

[0053] It should be noted that, please refer to Figure 2 and Figure 5 The upper clamp arm 110 has a second slot 150 at the end away from the guide structure 140. A container seat 160 is slidably connected in the second slot 150, and the sample collection container 400 is snapped into the container seat 160.

[0054] Please refer to Figure 6 and Figure 7 The cutting head 500 is detachably mounted on the movable cutter holder 300, and the cutting head 500 includes a cutter 510 and a connector 520. The connector 520 is fixed to the end of the cutter 510. The end of the connector 520 has an annular drug storage chamber 530. The opening of the annular drug storage chamber 530 faces the cutter 510. A drug storage and release structure 540 is provided inside the annular drug storage chamber 530. A pressing member 550 is also slidably arranged on the connector 520. An elastic pre-tightening member 560 is provided between the pressing member 550 and the connector 520.

[0055] For details, please refer to Figure 8 The extrusion component 550 includes a drive plate 551, a driven plate 552, and a slider 553. The driven plate 552 has multiple flow grooves 554 facing the cutter 510. The slider 553 is fixed between the drive plate 551 and the driven plate 552. The driven plate 552 is located inside the annular drug storage chamber 530, and the drive plate 551 is located outside the annular drug storage chamber 530. The elastic pre-tightening component 560 is fixed between the drive plate 551 and the connector 520.

[0056] It should be noted that, please refer to Figure 9 A rubber pad 570 is fixedly connected to the inner wall of the connector 520, which makes the connector 520 more securely engaged in the connector 320, and the rubber pad 570 can automatically compensate for the processing error between the connector 520 and the connector 320.

[0057] When the handle 200 drives the movable blade holder 300 to move toward the sample collection container 400, the movable blade holder 300 drives the cutting head 500 to perform cutting and sampling, and the obtained sample is contained in the sample collection container 400. During the sampling process, when the squeezing member 550 is squeezed by the sample tissue, it can compress the elastic pre-tightening member 560 and apply pressure to the drug storage and release structure 540, so that the drug is released from the opening of the annular drug storage chamber 530 to the sampling area, realizing the simultaneous sampling and drug administration.

[0058] By utilizing the annular drug storage chamber 530 and drug storage and release structure 540 of the cutting head 500, the pressure of the animal's ear on the squeezing member 550 is used during sampling to release the drug from the opening, achieving simultaneous sampling and drug administration, reducing the risk of bleeding and infection. The drive design of the movable cutter head 300 and the handle 200 ensures stable and efficient sampling action.

[0059] For details, please refer to Figure 10 The outer wall of the cutting tool 510 is provided with a guide groove 580. One end of the guide groove 580 is connected to the opening area of ​​the annular drug storage chamber 530, and the other end of the guide groove 580 extends toward the free end of the cutting tool 510.

[0060] It should be noted that there are multiple guide channels 580, which are evenly distributed along the circumference of the outer wall of the tool 510. The first end of each guide channel 580 is connected to the opening of the annular drug storage chamber 530, and the end of the guide channel 580 extends to the vicinity of the cutting edge of the tool 510.

[0061] The cross-section of the flow channel 580 is V-shaped or U-shaped, with a depth and width between 0.1 mm and 0.5 mm. The flow channel 580 guides the drug released from the annular drug storage tank 530 to the free end of the cutter 510, ensuring that the drug accurately covers the sampling area and improving drug delivery efficiency. During the instantaneous trigger release process, the main driving force for drug flow is the instantaneous hydraulic pressure generated by the pressure movement of the extruder 550. This pressure drives the drug to quickly pass through the flow channel 580 and cover the newly formed sampling wound.

[0062] In this embodiment, please refer to Figure 8 The drug storage and release structure 540 is a biodegradable sealing film containing the drug liquid. The end of the extruder 550 facing the drug storage and release structure 540 has a puncture member 590. When the extruder 550 is pressed and moves, the puncture member 590 punctures the sealing film and triggers the release of the drug liquid.

[0063] It should be noted that the sealing film is made of one or more of polyvinyl alcohol, polylactic acid-glycolic acid copolymer, chitosan or sodium alginate, and the film thickness is 0.05 mm to 0.2 mm. The liquid contains one or more of hemostatic agents (such as thrombin, Yunnan Baiyao), anesthetics (such as lidocaine), antibiotics (such as gentamicin) or growth factors that promote wound healing.

[0064] The sealed film-type drug storage and release structure 540, combined with the puncture member 590, punctures the film when the extrusion member 550 is pressed, achieving instantaneous triggering and one-time release, and using the mechanical pressure generated by the sampling action to instantly complete drug delivery.

[0065] When the handle 200 drives the movable blade holder 300 to push the cutting head 500 to perform cutting and sampling, the obtained sample tissue slices move together with the blade 510 towards the sample collection container 400. During this process, the animal's ear itself acts as a trigger medium, naturally squeezing the compression member 550 and overcoming the resistance of the elastic preload member 560, causing it to move backward. This movement then triggers the drug storage and release structure 540, causing the liquid medicine stored inside to be released instantaneously from the opening of the annular drug storage chamber 530 under mechanical pressure.

[0066] The released medication is precisely guided through specific flow channels 580 on the surface of the blade 510 to the newly formed wound area and the contact interface between the sample and the blade 510. This design achieves precise synchronization of three main functions:

[0067] Sampling function: The 510 blade completes tissue cutting.

[0068] Sample protection function: The sample is directly pushed into the sealed sample collection container 400 to achieve in-situ collection and isolate external contamination.

[0069] Wound pretreatment function: The immediate release of medication (such as hemostatic agents and anesthetics) can quickly close the wound and reduce exudate contamination of the sample. At the same time, the anesthetic components can quickly calm the animal's stress and keep it calm, making it easier for the operator to complete the current and subsequent sampling operations more accurately and safely, thereby indirectly ensuring the standardization and continuity of the sampling process.

[0070] It should be noted that the extrusion member 550, the elastic pretensioner 560, and the drug storage and release structure 540 together constitute a precise mechanical pressure feedback and triggering system. The elastic pretensioner 560 is a cylindrical helical compression spring, a disc spring, or an elastic rubber column.

[0071] At the moment the cutting and sampling are completed and the sample tissue slide retracts with the cutter 510, the tissue slide contacts the front end of the extruder 550 and applies pressure. The pre-pressure of the elastic pre-tightening member 560 is configured to be much greater than all possible interference pressures (such as pressure from animal tremors or struggles), but less than the effective triggering pressure that occurs after successful cutting and during sampling. If the interference pressure is less than 5N and the effective triggering pressure is between 8N and 15N, then the pre-pressure of the elastic pre-tightening member 560 is set to 6N to 7N, and the stiffness of the elastic pre-tightening member 560 is between 1.0N / mm and 2.0N / mm.

[0072] Since sampling livestock ears using this device is an instantaneous process, the squeezing element 550 is mainly subjected to effective triggering pressure that occurs after cutting and during sampling, which ensures the release of the drug solution. In addition, during sampling, the livestock ear tissue surrounding the sample tissue abuts against the sample collection container 400 of the upper clamp arm 110, so that the soft and unstable livestock ear tissue can provide a continuous and stable pressure to the squeezing element 550, ensuring the release of the drug solution.

[0073] After the liquid medicine (such as one containing gelatin, thrombin, or other fast-acting hemostatic components) is released, its main function is:

[0074] It acts quickly on the wound, promoting blood clotting and greatly reducing blood exudation. This is beneficial for wound healing in animals, and more importantly, it prevents excessive blood exudate from contaminating, diluting, or polluting the sample slide to be collected, ensuring the purity of the sample and the accuracy of subsequent analysis.

[0075] The local anesthetic components (such as lidocaine) provide rapid relief, calming animals that may be agitated due to pain, allowing operators to hold the instruments more steadily, ensuring accurate sample collection, and creating a quiet environment for subsequent sampling procedures. This approach aims to improve the success rate and efficiency of the sampling procedure itself, rather than to provide clinical treatment for the disease.

[0076] For details, please refer to Figure 11 The puncture component 590 includes a central puncture needle 591 and a plurality of expanding rods 592 surrounding the central puncture needle 591. The expanding rods 592 have bent portions, and the angle between the free end of the expanding rods 592 and the central puncture needle 591 is an acute angle.

[0077] The central needle 591 can quickly puncture the sealed film-type drug storage and release structure 540. The acute angle design of the expanding rod 592 increases the puncture area to ensure uniform drug release, and the bent part enhances the puncture effect.

[0078] Specifically, the outer wall of the expanding rod 592 has a protrusion 593 and a through hole 594, with the protrusion 593 and the through hole 594 arranged at intervals along the axial direction of the expanding rod 592.

[0079] The protrusion 593 and through hole 594 on the expanding rod 592 increase the drug flow channel, promote drug diffusion, and avoid blockage.

[0080] For details, please refer to Figure 12 A protective cover 501 is fitted on the outer wall of the connector 520. The surface of the protective cover 501 is provided with a third groove 502 that is interference-fitted with the connector 520. The inner diameter of the protective cover 501 is larger than the outer diameter of the extrusion part 550. The protective cover 501 achieves interference fit with the connector 520 through the third groove 502 to prevent the tool 510 from being contaminated or accidentally touched.

[0081] In another embodiment, the drug storage and release structure 540 is a porous adsorbent material impregnated with drug solution. The porous adsorbent material is a sponge or a fiber cotton strip. The porous adsorbent material serves as the drug storage and release structure 540, enabling continuous drug release and prolonging the duration of drug effect. It is suitable for scenarios where a slightly longer duration of drug effect is desired.

[0082] The specific working process of this sampling and detection device is as follows:

[0083] 1. Before sampling, install the cutting head 500 filled with the medicine solution onto the movable blade holder 300.

[0084] 2. Hold the device in your hand and position the animal's ear in the first slot 130.

[0085] 3. Grip the handle 200 firmly, and the movable blade holder 300 will drive the cutting head 500 forward to cut. Simultaneously, the sample tissue squeezes the squeezing component 550, triggering the puncture component 590 to puncture the sealing film. Under pressure, the medication is instantly released into the wound through the guide groove 580, achieving immediate analgesia and hemostasis. After sampling, the tissue sample is pushed into the sample collection container 400.

[0086] 4. Release handle 200, and all parts will reset under the action of the elastic element.

[0087] 5. When the drug storage and release structure 540 uses a porous adsorption material, its working principle is similar. The extruder 550 directly extrudes the material to release the drug solution, which is suitable for scenarios where a longer drug solution action time is desired.

[0088] 6. When not in use, the protective cover 501 can be clipped to the bottom of the connector 520 to prevent accidental contact with the extrusion part 550 and ensure safety.

[0089] This sampling and testing device integrates the previously separate steps of cutting, sampling, transferring, and administering medication into a single, continuous mechanical action. This is not a simple aggregation of functions, but rather a structural innovation that achieves a completely new working mode and technological effect. It significantly reduces the risk of sample contamination and degradation during transfer, ensuring the authenticity of genetic analysis materials. It significantly improves the overall efficiency and standardization of sampling operations, making it suitable for large-scale population screening. Through immediate medication processing, it creates favorable operating conditions for obtaining high-quality samples (e.g., reducing animal struggle) and ensures the initial state of the samples (reducing contamination from blood and other exudates), ultimately serving the core objective of improving sample quality.

[0090] It is important to note that the integration of the above multiple steps is not a simple spatial parallelism, but is achieved through rigorous mechanical linkage and timing control. Its workflow demonstrates a high degree of integration and intelligence.

[0091] Dependence on Trigger Mechanism: The drug delivery function is not triggered by a separate button or switch, but depends entirely on the successful completion of the sampling step. Specifically, the animal's ear itself can only act as a trigger to squeeze the squeeze unit 550 when the cutter 510 successfully cuts and carries the sample tissue slice toward the sample collection container 400. This means that if sampling is unsuccessful (no sample is obtained), the drug delivery function will not be activated, thus avoiding waste and accidental release of the drug. This successful sampling as a necessary condition for triggering drug delivery is a key manifestation of the deep integration of functions.

[0092] Precise timing synchronization: The release of the medication occurs in the instant between the completion of the cutting action and the sample being collected in the sample collection container 400. This ensures that the medication acts on the freshest wound, achieving optimal hemostasis or analgesia. As the medication flows through the guide channel 580, some of it covers the contact interface between the sample and the blade 510, rinsing or pre-treating the sample surface before it is pushed into the sample collection container 400, greatly reducing the chance of external contaminants adhering.

[0093] Unified power source: The ultimate power source for all actions comes from the user's single gripping operation of the handle 200. This force is precisely decomposed and transmitted through mechanical structures such as hinges and sliding, and is used to drive the cutting motion (movable blade holder 300) and generate the pressure required to release the liquid (extrusion component 550 retracts), realizing the function of one force driving multiple effects simultaneously.

[0094] While specific embodiments of the invention have been described in detail by way of examples, those skilled in the art should understand that the examples are for illustrative purposes only and not intended to limit the scope of the invention. Those skilled in the art should understand that modifications can be made to the above embodiments without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.

Claims

1. A sampling detection device, characterized by, include: The clamp body (100) includes an upper clamp arm (110) and a lower clamp arm (120), the surface of the upper clamp arm (110) having a first slot (130), and the upper clamp arm (110) having a guide structure (140) along its length direction. The handle (200) is hinged to the clamp body (100); The movable tool holder (300) is disposed on the guide structure (140) of the upper clamp arm (110) and is rotatably connected to the handle (200); A sample collection container (400) is detachably mounted on the front end of the upper clamp arm (110); A cutting head (500) is detachably mounted on the movable cutter holder (300) and includes a cutter (510) and a connector (520). The connector (520) is fixed to the end of the cutter (510). The end of the connector (520) has an annular drug storage chamber (530). The opening of the annular drug storage chamber (530) faces the cutter (510). A drug storage and release structure (540) is provided inside the annular drug storage chamber (530). A pressing member (550) is also slidably disposed on the connector (520). An elastic pre-tightening member (560) is provided between the pressing member (550) and the connector (520). The guide structure (140) consists of a through groove (141) at the end of the upper clamp arm (110) and a limiting groove (142) on the surface of the upper clamp arm (110). The movable tool holder (300) is slidably connected in the through groove (141). The movable tool holder (300) and the handle (200) are rotatably connected by a limiting post (143). The surface of the handle (200) is provided with a first groove (210). The limiting post (143) is slidably connected in both the limiting groove (142) and the first groove (210). The drug storage and release structure (540) is a biodegradable sealing film containing liquid medicine. The extruder (550) has a puncture member (590) at one end facing the drug storage and release structure (540). When the extruder (550) is pressed and moves, the puncture member (590) punctures the sealing film. When the handle (200) drives the movable blade holder (300) to move toward the sample collection container (400), the movable blade holder (300) drives the cutting head (500) to perform cutting and sampling, and the obtained sample is contained in the sample collection container (400). During the sampling process, when the extruder (550) is squeezed by the tissue around the sample, it can compress the elastic pre-tightening member (560) and apply pressure to the drug storage and release structure (540), so that the drug is released from the opening of the annular drug storage chamber (530) to the sampling area.

2. The sampling detection device of claim 1, wherein The upper clamp arm (110) has a second slot (150) at one end away from the guide structure (140), and a container seat (160) is slidably connected in the second slot (150), and the sample collection container (400) is snapped into the container seat (160).

3. The sampling detection device of claim 2, wherein A rubber pad (570) is fixedly connected to the inner wall of the connector (520).

4. The sampling detection device of claim 1, wherein The extrusion piece (550) comprises a driving plate (551), a driven plate (552) provided with a plurality of flow-through grooves (554) facing the cutter (510), and a slider (553) fixed between the driving plate (551) and the driven plate (552), wherein the driven plate (552) is located in the annular medicine storage bin (530), the driving plate (551) is located outside the annular medicine storage bin (530), and the elastic pre-tightening piece (560) is fixed between the driving plate (551) and the butt joint (520).

5. A sampling detection device according to claim 4, wherein The outer wall of the cutter (510) is provided with a flow guide groove (580), one end of the flow guide groove (580) is in communication with the opening area of the annular medicine storage bin (530), and the other end of the flow guide groove (580) extends to the free end of the cutter (510).

6. The sampling detection device of claim 5, wherein, The piercing piece (590) comprises a central piercing needle (591) and a plurality of hole expanding rods (592) surrounding the central piercing needle (591), the hole expanding rods (592) have bending portions, and the included angle between the free end of the hole expanding rod (592) and the central piercing needle (591) is an acute angle.

7. A sampling detection device according to claim 6, wherein The outer wall of the hole expanding rod (592) is provided with protrusions (593) and through holes (594), and the protrusions (593) and the through holes (594) are arranged in an axial direction of the hole expanding rod (592).

8. The sampling detection device of claim 7, wherein, The medicine storage and release structure (540) is a porous adsorption material impregnated with a medicine solution.

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