Composition for improving stability of hydroxytyrosol and derivatives thereof and application

Abstract

The invention provides a composition for improving the stability of hydroxytyrosol and derivatives thereof and application of the composition. The composition comprises hydroxytyrosol and derivatives thereof, and one or more of acetyl hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract or ergothioneine. The composition can be applied to the field of cosmetics, and the stability of non-emulsifying system and emulsifying system products containing hydroxytyrosol or hydroxytyrosol butyrate prepared in the combination mode is obviously improved.

Description

Technical Field

[0001] This application relates to the field of cosmetic technology, specifically to a composition and its application for improving the stability of hydroxytyrosol and its derivatives. Background Technology

[0002] Hydroxytyrosol (HT) is the main polyphenolic compound in olive oil, chemically named 3,4-dihydroxyphenylethanol, and is the most bioactive component of olive oil. Hydroxytyrosol has two phenolic hydroxyl groups and one alcoholic hydroxyl group in its structure, with a molecular weight of 154.16 and a melting point of around 53°C. It exhibits good fat and water solubility, showing good solubility in water and polar organic solvents such as low molecular weight alcohols, and is readily soluble in water and dimethyl sulfoxide. Hydroxytyrosol possesses strong antioxidant activity and is currently widely used in cosmetics, health products, and food and beverages, offering benefits such as skin whitening, anti-aging, and cardiovascular protection.

[0003] Hydroxytyrosol and its derivatives have excellent antioxidant and anti-aging activities. However, because the unshared electron pair of the O on the -OH on the benzene ring forms p-π conjugation with the benzene ring, it exhibits an electron-donating effect, which increases the electron cloud density on the benzene ring. This substance has a relatively large electron cloud density, making electron transitions easy and the binding ability of electrons relatively weak. It is easily captured by oxidants, undergoes oxidation reactions, and causes discoloration. Summary of the Invention

[0004] This application provides a composition and its application for improving the stability of hydroxytyrosol and its derivatives.

[0005] This application involves the following:

[0006] 1. Use of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and / or ergothioneine in improving the stability of hydroxytyrosol and its derivatives.

[0007] 2. The use according to claim 1, wherein the derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate or hydroxytyrosol glucoside.

[0008] 3. According to the use described in either item 1 or 2, wherein the mass ratios of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine to hydroxytyrosol and its derivatives are respectively:

[0009] The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1;

[0010] The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1;

[0011] The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.1.

[0012] The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.1.

[0013] 4. Use of two, three, or four of the following in improving the stability of hydroxytyrosol and its derivatives: acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine.

[0014] 5. The use according to item 4, wherein the derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate or hydroxytyrosol glucoside.

[0015] 6. The use according to any one of items 4 or 5, wherein the combination is selected from any one of (1) to (10):

[0016] (1) Acetylhydroxyproline and ergothioneine; or

[0017] (2) Oxothiazolidinic acid and ergothioneine; or

[0018] (3) Italian kale extract and ergothioneine; or

[0019] (4) Acetylhydroxyproline and Italian kale extract; or

[0020] (5) Oxothiazolidinic acid and Italian kale extract; or

[0021] (6) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract; or

[0022] (7) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine; or

[0023] (8) Acetylhydroxyproline, Italian kale extract, and ergothioneine; or

[0024] (9) Oxothiazolidinic acid, Italian cabbage extract, and ergothioneine; or

[0025] (10) Acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine.

[0026] 7. The use according to either item 4 or 5, wherein,

[0027] The total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.2):0.1.

[0028] The total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives was (0.04-0.2):0.1.

[0029] The total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.13):0.1.

[0030] The total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.06-0.15):0.1.

[0031] The total mass ratio of oxothiazolidine carboxylic acid and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.05-0.13):0.1.

[0032] The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.08-0.18):0.1.

[0033] The total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.3):0.1.

[0034] The total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.08-0.18):0.1.

[0035] The total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.15):0.1.

[0036] The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.1-0.2):0.1.

[0037] 8. A composition for improving the stability of hydroxytyrosol and its derivatives, wherein the composition comprises one, two, three, or four of the following: acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine.

[0038] 9. The composition according to claim 8, wherein the derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate, or hydroxytyrosol glucoside.

[0039] 10. The composition according to any one of items 8 or 9, wherein the composition is selected from any one of (1) to (10):

[0040] (1) Acetylhydroxyproline and ergothioneine; or

[0041] (2) Oxothiazolidinic acid and ergothioneine; or

[0042] (3) Italian kale extract and ergothioneine; or

[0043] (4) Acetylhydroxyproline and Italian kale extract; or

[0044] (5) Oxothiazolidinic acid and Italian kale extract; or

[0045] (6) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract; or

[0046] (7) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine; or

[0047] (8) Acetylhydroxyproline, Italian kale extract, and ergothioneine; or

[0048] (9) Oxothiazolidinic acid, Italian cabbage extract, and ergothioneine; or

[0049] (10) Acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine.

[0050] 11. The composition according to any one of claims 8 or 9, wherein, when the composition is combined with hydroxytyrosol and its derivatives,

[0051] The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1;

[0052] The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1;

[0053] The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.1.

[0054] The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.1.

[0055] 12. The composition according to any one of claims 8 or 9, wherein, when the composition is combined with hydroxytyrosol and its derivatives,

[0056] The total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.2):0.1.

[0057] The total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives was (0.04-0.2):0.1.

[0058] The total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.13):0.1.

[0059] The total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.06-0.15):0.1.

[0060] The total mass ratio of oxothiazolidine carboxylic acid and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.05-0.13):0.1.

[0061] The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.08-0.18):0.1.

[0062] The total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.3):0.1.

[0063] The total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.08-0.18):0.1.

[0064] The total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.15):0.1.

[0065] The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.1-0.2):0.1.

[0066] 13. A composition comprising hydroxytyrosol and its derivatives, and one, two, three, or four of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine.

[0067] 14. The composition according to claim 13, wherein the derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate, or hydroxytyrosol glucoside.

[0068] 15. The composition according to any one of items 13 or 14, wherein,

[0069] The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1;

[0070] The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1;

[0071] The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.1.

[0072] The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.1.

[0073] 16. The composition according to any one of items 13 or 14, wherein,

[0074] The total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.2):0.1.

[0075] The total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives was (0.04-0.2):0.1.

[0076] The total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.13):0.1.

[0077] The total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.06-0.15):0.1.

[0078] The total mass ratio of oxothiazolidine carboxylic acid and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.05-0.13):0.1.

[0079] The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.08-0.18):0.1.

[0080] The total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.3):0.1.

[0081] The total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.08-0.18):0.1.

[0082] The total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.15):0.1.

[0083] The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.1-0.2):0.1.

[0084] 17. The composition according to any one of items 13 or 14, wherein the mass ratio of hydroxytyrosol and its derivatives, acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine is 0.1:(0.03-3):(0.02-2):(0.03-5):(0.02-6).

[0085] 18. A cosmetic product comprising a composition according to any one of claims 8 to 12 for improving the stability of hydroxytyrosol and its derivatives, or a composition according to any one of claims 13 to 17, and a carrier and / or excipients.

[0086] 19. The use of the composition according to any one of items 8 to 12 for improving the stability of hydroxytyrosol and its derivatives, or the composition according to any one of items 13 to 17, in the preparation of cosmetics.

[0087] Invention effects:

[0088] The composition provided in this application can effectively improve the stability of hydroxytyrosol and its derivatives;

[0089] The composition provided in this application can be applied in the cosmetics field, and the stability of non-emulsified and emulsified products containing hydroxytyrosol or hydroxytyrosol butyrate formulated by this combination is significantly improved. Attached Figure Description

[0090] Figure 1 This is a schematic diagram of the color just prepared in Example 1.

[0091] Figure 2 This is a schematic diagram of the colors observed in Example 1 over 60 days.

[0092] Figure 3 This is a color diagram observed over 60 days in Example 9.

[0093] Figure 4 This is a schematic diagram of the colors observed over 60 days in Example 12.

[0094] Figure 5 This is a schematic diagram of the colors observed in Comparative Example 1 over 60 days. Detailed Implementation

[0095] The following description provides exemplary embodiments of this application, including various details to aid understanding, and should be considered merely exemplary. Therefore, those skilled in the art will recognize that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of this application. Similarly, for clarity and brevity, descriptions of well-known functions and structures are omitted in the following description.

[0096] As used throughout the specification and claims, the terms "comprising" or "including" are open-ended and should be interpreted as "comprising but not limited to". The following descriptions in the specification are preferred embodiments for carrying out this application; however, these descriptions are for the purpose of understanding the general principles of the specification and are not intended to limit the scope of this application.

[0097] This application provides the use of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and / or ergothioneine in improving the stability of hydroxytyrosol and its derivatives.

[0098] In this application, hydroxytyrosol derivatives include, but are not limited to, hydroxytyrosol esters and hydroxytyrosol glycosides, such as hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate, and hydroxytyrosol glucoside.

[0099] In this application, the mass ratios of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract or ergothioneine to hydroxytyrosol and its derivatives are as follows:

[0100] The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1;

[0101] The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1;

[0102] The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.1.

[0103] The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.1.

[0104] For a mass ratio of (0.1-3):0.1, 0.1-3 can encompass any value between 0.1 and 3. For example, the mass ratio of acetylhydroxyproline to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, or 1.1:0.1. 1, 1.2: 0.1, 1.3: 0.1, 1.4: 0.1, 1.5: 0.1, 1.6: 0.1, 1.7: 0.1, 1.8: 0.1, 1.9: 0.1, 2: 0.1, 2.1: 0.1, 2.2: 0.1, 2.3: 0.1, 2.4: 0.1, 2.5: 0.1, 2.6: 0.1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1.

[0105] In some embodiments, the mass ratio of acetylhydroxyproline to hydroxytyrosol is 0.1:0.1, 1:0.1, or 3:0.1.

[0106] For a mass ratio of (0.1-2):0.1, 0.1-2 can encompass any value between 0.1 and 2. For example, the mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, or 2:0.1.

[0107] In some embodiments, the mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol is 0.1:0.1, 1:0.1, or 2:0.1.

[0108] For a mass ratio of (0.1-5):0.1, 0.1-5 can encompass any value between 0.1 and 5. For example, the mass ratio of Italian kale extract to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, 2:0.1, 2.1:0.1. 1, 2.2: 0.1, 2.3: 0.1, 2.4: 0.1, 2.5: 0.1, 2.6: 0.1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1, 3.1: 0.1, 3.2: 0.1, 3.3: 0.1, 3.4: 0.1, 3.5: 0.1, 3.6: 0.1, 3.7: 0.1, 3.8: 0.1, 3.9: 0.1, 4: 0.1, 4.1: 0.1, 4.2: 0.1, 4.3: 0.1, 4.4: 0.1, 4.5: 0.1, 4.6: 0.1, 4.7: 0.1, 4.8: 0.1, 4.9: 0.1, 5: 0.1.

[0109] In some embodiments, the mass ratio of Italian kale extract to hydroxytyrosol is 0.1:0.1, 1:0.1, or 5:0.1.

[0110] For a mass ratio of (0.1-6):0.1, 0.1-6 can encompass any value between 0.1 and 6. For example, the mass ratio of ergothioneine to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1. 1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, 2:0.1, 2.1:0.1, 2.2:0.1, 2.3:0.1, 2.4:0.1, 2.5:0.1, 2.6:0. 1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1, 3.1: 0.1, 3.2: 0.1, 3.3: 0.1, 3.4: 0.1, 3.5: 0.1, 3.6: 0.1, 3.7: 0.1, 3.8: 0.1, 3.9: 0.1, 4: 0.1, 4.1: 0.1, 4.2: 0.1, 4.3: 0.1 4.4:0.1, 4.5:0.1, 4.6:0.1, 4.7:0.1, 4.8:0.1, 4.9:0.1, 5:0.1, 5.1:0.1, 5.2:0.1, 5.3:0.1, 5.4:0.1, 5.5:0.1, 5.6:0.1, 5.7:0.1, 5.8:0.1, 5.9:0.1, 6:0.1.

[0111] In some embodiments, the mass ratio of ergothioneine to hydroxytyrosol is 0.1:0.1, 1:0.1, or 6:0.1.

[0112] This application provides the use of two, three, or four of the following ingredients in improving the stability of hydroxytyrosol and its derivatives: acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine.

[0113] In this application, the combination is selected from any one of the following (1) to (10): (1) acetylhydroxyproline and ergothioneine; or (2) oxothiazolidinylcarboxylic acid and ergothioneine; or (3) Italian cabbage extract and ergothioneine; or (4) acetylhydroxyproline and Italian cabbage extract; or (5) oxothiazolidinylcarboxylic acid and Italian cabbage extract; or (6) acetylhydroxyproline, oxothiazolidinylcarboxylic acid and Italian cabbage extract; or (7) acetylhydroxyproline, oxothiazolidinylcarboxylic acid and ergothioneine; or (8) acetylhydroxyproline, Italian cabbage extract and ergothioneine; or (9) oxothiazolidinylcarboxylic acid, Italian cabbage extract and ergothioneine; or (10) acetylhydroxyproline, oxothiazolidinylcarboxylic acid, Italian cabbage extract and ergothioneine.

[0114] In this application, the total mass ratio of acetylhydroxyproline and ergothioneine to hydroxytyrosol and its derivatives is (0.05-0.2):0.1. The range of 0.05-0.2 can encompass any value between 0.05 and 0.2; for example, the total mass ratio of acetylhydroxyproline and ergothioneine to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0115] In some embodiments, the total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.2:0.1, 0.07:0.1, 0.05:0.1, 0.15:0.1, or 0.12:0.1.

[0116] In this application, the mass ratio of the total mass of oxothiazolidinic acid and ergothioneine to hydroxytyrosol and its derivatives is (0.04-0.2):0.1. The range of 0.04-0.2 can encompass any value between 0.04 and 0.2; for example, the mass ratio of the total mass of oxothiazolidinic acid and ergothioneine to hydroxytyrosol and its derivatives can be 0.04:0.1, 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0117] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.2:0.1, 0.05:0.1, 0.07:0.1, 0.04:0.1, or 0.12:0.1.

[0118] In this application, the mass ratio of the total mass of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives is (0.05-0.13):0.1. The range of 0.05-0.13 can encompass any value between 0.05 and 0.13; for example, the mass ratio of the total mass of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, or 0.13:0.1.

[0119] In some embodiments, the total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.05:0.1, 0.12:0.1, or 0.13:0.1.

[0120] In this application, the mass ratio of the total mass of acetylated hydroxyproline and Italian kale extract to hydroxytyrosol and its derivatives is (0.06-0.15):0.1. The range of 0.06-0.15 can encompass any value between 0.06 and 0.15; for example, the mass ratio of the total mass of acetylated hydroxyproline and Italian kale extract to hydroxytyrosol and its derivatives can be 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, or 0.15:0.1.

[0121] In some embodiments, the total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives is 0.1:0.1, 0.08:0.1, 0.06:0.1, 0.15:0.1, or 0.13:0.1.

[0122] In this application, the mass ratio of the total mass of oxothiazolidinic acid and Italian kale extract to hydroxytyrosol and its derivatives is (0.05-0.13):0.1. The range of 0.05-0.13 can encompass any value between 0.05 and 0.13; for example, the mass ratio of the total mass of oxothiazolidinic acid and Italian kale extract to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, or 0.13:0.1.

[0123] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid and Italian kale extract to hydroxytyrosol and its derivatives is 0.1:0.1, 0.08:0.1, 0.05:0.1, or 0.13:0.1.

[0124] In this application, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract to hydroxytyrosol and its derivatives is (0.08-0.18):0.1. The range of 0.08-0.18 can encompass any value between 0.08 and 0.18; for example, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract to hydroxytyrosol and its derivatives can be 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, or 0.18:0.1.

[0125] In some embodiments, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, 0.08:0.1, or 0.18:0.1.

[0126] In this application, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives is (0.07-0.3):0.1. The range of 0.07-0.3 can encompass any value between 0.07 and 0.3; for example, the mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives can be 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, or 0.14:0.1. 1. 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, 0.2:0.1, 0.21:0.1, 0.22:0.1, 0.23:0.1, 0.24:0.1, 0.25:0.1, 0.26:0.1, 0.27:0.1, 0.28:0.1, 0.29:0.1, 0.3:0.1.

[0127] In some embodiments, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.3:0.1, 0.1:0.1, 0.07:0.1, or 0.17:0.1.

[0128] In this application, the mass ratio of the total mass of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is (0.08-0.18):0.1. The range of 0.08-0.18 can encompass any value between 0.08 and 0.18; for example, the mass ratio of the total mass of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, or 0.18:0.1.

[0129] In some embodiments, the total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, 0.08:0.1, or 0.18:0.1.

[0130] In this application, the mass ratio of the total mass of oxothiazolidinic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is (0.07-0.15):0.1. The range of 0.07-0.15 can be any value between 0.07 and 0.15; for example, the mass ratio of the total mass of oxothiazolidinic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, or 0.15:0.1.

[0131] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, or 0.07:0.1.

[0132] In this application, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is (0.1-0.2):0.1. For 0.1-0.2, it can encompass any value between 0.1 and 0.2; for example, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0133] In some embodiments, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1 or 0.2:0.1.

[0134] This application provides a composition for improving the stability of hydroxytyrosol and its derivatives, wherein the composition comprises one, two, three, or four of the following: acetylhydroxyproline, oxothiazolidinecarboxylic acid, Italian cabbage extract, or ergothioneine.

[0135] In this application, the composition is selected from any one of the following (1) to (10): (1) acetylhydroxyproline and ergothioneine; or (2) oxothiazolidinylcarboxylic acid and ergothioneine; or (3) Italian cabbage extract and ergothioneine; or (4) acetylhydroxyproline and Italian cabbage extract; or (5) oxothiazolidinylcarboxylic acid and Italian cabbage extract; or (6) acetylhydroxyproline, oxothiazolidinylcarboxylic acid and Italian cabbage extract; or (7) acetylhydroxyproline, oxothiazolidinylcarboxylic acid and ergothioneine; or (8) acetylhydroxyproline, Italian cabbage extract and ergothioneine; or (9) oxothiazolidinylcarboxylic acid, Italian cabbage extract and ergothioneine; or (10) acetylhydroxyproline, oxothiazolidinylcarboxylic acid, Italian cabbage extract and ergothioneine.

[0136] In this application, the mass ratios of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine to hydroxytyrosol and its derivatives in the above-mentioned compositions for improving the stability of hydroxytyrosol and its derivatives are as follows:

[0137] The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1;

[0138] The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1;

[0139] The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.1.

[0140] The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.1.

[0141] For a mass ratio of (0.1-3):0.1, 0.1-3 can encompass any value between 0.1 and 3. For example, the mass ratio of acetylhydroxyproline to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, or 1.1:0.1. 1, 1.2: 0.1, 1.3: 0.1, 1.4: 0.1, 1.5: 0.1, 1.6: 0.1, 1.7: 0.1, 1.8: 0.1, 1.9: 0.1, 2: 0.1, 2.1: 0.1, 2.2: 0.1, 2.3: 0.1, 2.4: 0.1, 2.5: 0.1, 2.6: 0.1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1.

[0142] In some embodiments, the mass ratio of acetylhydroxyproline to hydroxytyrosol is 0.1:0.1, 1:0.1, or 3:0.1.

[0143] For a mass ratio of (0.1-2):0.1, 0.1-2 can encompass any value between 0.1 and 2. For example, the mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, or 2:0.1.

[0144] In some embodiments, the mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol is 0.1:0.1, 1:0.1, or 2:0.1.

[0145] For a mass ratio of (0.1-5):0.1, 0.1-5 can encompass any value between 0.1 and 5. For example, the mass ratio of Italian kale extract to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, 2:0.1, 2.1:0.1. 1, 2.2: 0.1, 2.3: 0.1, 2.4: 0.1, 2.5: 0.1, 2.6: 0.1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1, 3.1: 0.1, 3.2: 0.1, 3.3: 0.1, 3.4: 0.1, 3.5: 0.1, 3.6: 0.1, 3.7: 0.1, 3.8: 0.1, 3.9: 0.1, 4: 0.1, 4.1: 0.1, 4.2: 0.1, 4.3: 0.1, 4.4: 0.1, 4.5: 0.1, 4.6: 0.1, 4.7: 0.1, 4.8: 0.1, 4.9: 0.1, 5: 0.1.

[0146] In some embodiments, the mass ratio of Italian kale extract to hydroxytyrosol is 0.1:0.1, 1:0.1, or 5:0.1.

[0147] For a mass ratio of (0.1-6):0.1, 0.1-6 can encompass any value between 0.1 and 6. For example, the mass ratio of ergothioneine to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1. 1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, 2:0.1, 2.1:0.1, 2.2:0.1, 2.3:0.1, 2.4:0.1, 2.5:0.1, 2.6:0. 1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1, 3.1: 0.1, 3.2: 0.1, 3.3: 0.1, 3.4: 0.1, 3.5: 0.1, 3.6: 0.1, 3.7: 0.1, 3.8: 0.1, 3.9: 0.1, 4: 0.1, 4.1: 0.1, 4.2: 0.1, 4.3: 0.1 4.4:0.1, 4.5:0.1, 4.6:0.1, 4.7:0.1, 4.8:0.1, 4.9:0.1, 5:0.1, 5.1:0.1, 5.2:0.1, 5.3:0.1, 5.4:0.1, 5.5:0.1, 5.6:0.1, 5.7:0.1, 5.8:0.1, 5.9:0.1, 6:0.1.

[0148] In some embodiments, the mass ratio of ergothioneine to hydroxytyrosol is 0.1:0.1, 1:0.1, or 6:0.1.

[0149] In this application, the total mass ratio of acetylhydroxyproline and ergothioneine to hydroxytyrosol and its derivatives in the composition for improving the stability of hydroxytyrosol and its derivatives is (0.05-0.2):0.1. The range of 0.05-0.2 can encompass any value between 0.05 and 0.2; for example, the total mass ratio of acetylhydroxyproline and ergothioneine to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0150] In some embodiments, the total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.2:0.1, 0.07:0.1, 0.05:0.1, 0.15:0.1, or 0.12:0.1.

[0151] In this application, the total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives in the above-mentioned composition for improving the stability of hydroxytyrosol and its derivatives is (0.04-0.2):0.1. For 0.04-0.2, it can cover any value between 0.04 and 0.2. For example, the mass ratio of the total mass of oxothiazolidine carboxylic acid and ergothioneine to the mass ratio of hydroxytyrosol and its derivatives can be 0.04:0.1, 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, 0.2:0.1.

[0152] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.2:0.1, 0.05:0.1, 0.07:0.1, 0.04:0.1, or 0.12:0.1.

[0153] In this application, the mass ratio of the total mass of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives in the composition for improving the stability of hydroxytyrosol and its derivatives is (0.05-0.13):0.1. The range of 0.05-0.13 can encompass any value between 0.05 and 0.13; for example, the mass ratio of the total mass of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, or 0.13:0.1.

[0154] In some embodiments, the total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.05:0.1, 0.12:0.1, or 0.13:0.1.

[0155] In this application, the mass ratio of the total mass of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives in the above-mentioned composition for improving the stability of hydroxytyrosol and its derivatives is (0.06-0.15):0.1. The range of 0.06-0.15 can encompass any value between 0.06 and 0.15; for example, the mass ratio of the total mass of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives can be 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, or 0.15:0.1.

[0156] In some embodiments, the total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives is 0.1:0.1, 0.08:0.1, 0.06:0.1, 0.15:0.1, or 0.13:0.1.

[0157] In this application, the mass ratio of the total mass of oxothiazolidinic acid and Italian cabbage extract to hydroxytyrosol and its derivatives in the above-mentioned composition for improving the stability of hydroxytyrosol and its derivatives is (0.05-0.13):0.1. The range of 0.05-0.13 can encompass any value between 0.05 and 0.13; for example, the mass ratio of the total mass of oxothiazolidinic acid and Italian cabbage extract to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, or 0.13:0.1.

[0158] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid and Italian kale extract to hydroxytyrosol and its derivatives is 0.1:0.1, 0.08:0.1, 0.05:0.1, or 0.13:0.1.

[0159] In this application, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives in the above-mentioned composition for improving the stability of hydroxytyrosol and its derivatives is (0.08-0.18):0.1. The range of 0.08-0.18 can encompass any value between 0.08 and 0.18; for example, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives can be 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, or 0.18:0.1.

[0160] In some embodiments, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, 0.08:0.1, or 0.18:0.1.

[0161] In this application, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives in the above-mentioned composition for improving the stability of hydroxytyrosol and its derivatives is (0.07-0.3):0.1. The range of 0.07-0.3 can encompass any value between 0.07 and 0.3; for example, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives can be 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, or 0.14:0.1. 1. 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, 0.2:0.1, 0.21:0.1, 0.22:0.1, 0.23:0.1, 0.24:0.1, 0.25:0.1, 0.26:0.1, 0.27:0.1, 0.28:0.1, 0.29:0.1, 0.3:0.1.

[0162] In some embodiments, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.3:0.1, 0.1:0.1, 0.07:0.1, or 0.17:0.1.

[0163] In this application, the total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives in the composition for improving the stability of hydroxytyrosol and its derivatives is (0.08-0.18):0.1. The range of 0.08-0.18 can encompass any value between 0.08 and 0.18; for example, the total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, or 0.18:0.1.

[0164] In some embodiments, the total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, 0.08:0.1, or 0.18:0.1.

[0165] In this application, the mass ratio of the total mass of oxothiazolidinic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives in the composition for improving the stability of hydroxytyrosol and its derivatives is (0.07-0.15):0.1. The range of 0.07-0.15 can be any value between 0.07 and 0.15; for example, the mass ratio of the total mass of oxothiazolidinic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, or 0.15:0.1.

[0166] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, or 0.07:0.1.

[0167] In this application, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives in the above-mentioned composition for improving the stability of hydroxytyrosol and its derivatives is (0.1-0.2):0.1. For 0.1-0.2, it can cover any value between 0.1 and 0.2; for example, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0168] In some embodiments, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1 or 0.2:0.1.

[0169] This application provides a composition comprising hydroxytyrosol and its derivatives, and one, two, three, or four of the following: acetylhydroxyproline, oxothiazolidinecarboxylic acid, Italian cabbage extract, or ergothioneine.

[0170] In this application, the mass ratios of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract or ergothioneine to hydroxytyrosol and its derivatives in the above composition are as follows:

[0171] The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1;

[0172] The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1;

[0173] The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.1.

[0174] The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.1.

[0175] For a mass ratio of (0.1-3):0.1, 0.1-3 can encompass any value between 0.1 and 3. For example, the mass ratio of acetylhydroxyproline to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, or 1.1:0.1. 1, 1.2: 0.1, 1.3: 0.1, 1.4: 0.1, 1.5: 0.1, 1.6: 0.1, 1.7: 0.1, 1.8: 0.1, 1.9: 0.1, 2: 0.1, 2.1: 0.1, 2.2: 0.1, 2.3: 0.1, 2.4: 0.1, 2.5: 0.1, 2.6: 0.1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1.

[0176] In some embodiments, the mass ratio of acetylhydroxyproline to hydroxytyrosol is 0.1:0.1, 1:0.1, or 3:0.1.

[0177] For a mass ratio of (0.1-2):0.1, 0.1-2 can encompass any value between 0.1 and 2. For example, the mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, or 2:0.1.

[0178] In some embodiments, the mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol is 0.1:0.1, 1:0.1, or 2:0.1.

[0179] For a mass ratio of (0.1-5):0.1, 0.1-5 can encompass any value between 0.1 and 5. For example, the mass ratio of Italian kale extract to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, 2:0.1, 2.1:0.1. 1, 2.2: 0.1, 2.3: 0.1, 2.4: 0.1, 2.5: 0.1, 2.6: 0.1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1, 3.1: 0.1, 3.2: 0.1, 3.3: 0.1, 3.4: 0.1, 3.5: 0.1, 3.6: 0.1, 3.7: 0.1, 3.8: 0.1, 3.9: 0.1, 4: 0.1, 4.1: 0.1, 4.2: 0.1, 4.3: 0.1, 4.4: 0.1, 4.5: 0.1, 4.6: 0.1, 4.7: 0.1, 4.8: 0.1, 4.9: 0.1, 5: 0.1.

[0180] In some embodiments, the mass ratio of Italian kale extract to hydroxytyrosol is 0.1:0.1, 1:0.1, or 5:0.1.

[0181] For a mass ratio of (0.1-6):0.1, 0.1-6 can encompass any value between 0.1 and 6. For example, the mass ratio of ergothioneine to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.2:0.1, 0.3:0.1, 0.4:0.1, 0.5:0.1, 0.6:0.1, 0.7:0.1, 0.8:0.1, 0.9:0.1. 1, 1:0.1, 1.1:0.1, 1.2:0.1, 1.3:0.1, 1.4:0.1, 1.5:0.1, 1.6:0.1, 1.7:0.1, 1.8:0.1, 1.9:0.1, 2:0.1, 2.1:0.1, 2.2:0.1, 2.3:0.1, 2.4:0.1, 2.5:0.1, 2.6:0. 1, 2.7: 0.1, 2.8: 0.1, 2.9: 0.1, 3: 0.1, 3.1: 0.1, 3.2: 0.1, 3.3: 0.1, 3.4: 0.1, 3.5: 0.1, 3.6: 0.1, 3.7: 0.1, 3.8: 0.1, 3.9: 0.1, 4: 0.1, 4.1: 0.1, 4.2: 0.1, 4.3: 0.1 4.4:0.1, 4.5:0.1, 4.6:0.1, 4.7:0.1, 4.8:0.1, 4.9:0.1, 5:0.1, 5.1:0.1, 5.2:0.1, 5.3:0.1, 5.4:0.1, 5.5:0.1, 5.6:0.1, 5.7:0.1, 5.8:0.1, 5.9:0.1, 6:0.1.

[0182] In some embodiments, the mass ratio of ergothioneine to hydroxytyrosol is 0.1:0.1, 1:0.1, or 6:0.1.

[0183] In this application, the mass ratio of the total mass of acetylhydroxyproline and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.05-0.2):0.1. The range of 0.05-0.2 can encompass any value between 0.05 and 0.2; for example, the mass ratio of the total mass of acetylhydroxyproline and ergothioneine to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0184] In some embodiments, the total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.2:0.1, 0.07:0.1, 0.05:0.1, 0.15:0.1, or 0.12:0.1.

[0185] In this application, the mass ratio of the total mass of oxothiazolidinic acid and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.04-0.2):0.1. The range of 0.04-0.2 can encompass any value between 0.04 and 0.2; for example, the mass ratio of the total mass of oxothiazolidinic acid and ergothioneine to hydroxytyrosol and its derivatives can be 0.04:0.1, 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0186] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.2:0.1, 0.05:0.1, 0.07:0.1, 0.04:0.1, or 0.12:0.1.

[0187] In this application, the mass ratio of the total mass of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.05-0.13):0.1. The range of 0.05-0.13 can encompass any value between 0.05 and 0.13; for example, the mass ratio of the total mass of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, or 0.13:0.1.

[0188] In some embodiments, the total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1, 0.05:0.1, 0.12:0.1, or 0.13:0.1.

[0189] In this application, the mass ratio of the total mass of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives in the above composition is (0.06-0.15):0.1. The range of 0.06-0.15 can encompass any value between 0.06 and 0.15; for example, the mass ratio of the total mass of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives can be 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, or 0.15:0.1.

[0190] In some embodiments, the total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives is 0.1:0.1, 0.08:0.1, 0.06:0.1, 0.15:0.1, or 0.13:0.1.

[0191] In this application, the mass ratio of the total mass of oxothiazolidinic acid and Italian cabbage extract to hydroxytyrosol and its derivatives in the above composition is (0.05-0.13):0.1. The range of 0.05-0.13 can encompass any value between 0.05 and 0.13; for example, the mass ratio of the total mass of oxothiazolidinic acid and Italian cabbage extract to hydroxytyrosol and its derivatives can be 0.05:0.1, 0.06:0.1, 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, or 0.13:0.1.

[0192] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid and Italian kale extract to hydroxytyrosol and its derivatives is 0.1:0.1, 0.08:0.1, 0.05:0.1, or 0.13:0.1.

[0193] In this application, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives in the above composition is (0.08-0.18):0.1. The range of 0.08-0.18 can encompass any value between 0.08 and 0.18; for example, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives can be 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, or 0.18:0.1.

[0194] In some embodiments, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, 0.08:0.1, or 0.18:0.1.

[0195] In this application, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.07-0.3):0.1. The range of 0.07-0.3 can encompass any value between 0.07 and 0.3; for example, the mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives can be 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, or 0.14:0.1. 1. 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, 0.2:0.1, 0.21:0.1, 0.22:0.1, 0.23:0.1, 0.24:0.1, 0.25:0.1, 0.26:0.1, 0.27:0.1, 0.28:0.1, 0.29:0.1, 0.3:0.1.

[0196] In some embodiments, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.3:0.1, 0.1:0.1, 0.07:0.1, or 0.17:0.1.

[0197] In this application, the mass ratio of the total mass of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.08-0.18):0.1. The range of 0.08-0.18 can encompass any value between 0.08 and 0.18; for example, the mass ratio of the total mass of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, or 0.18:0.1.

[0198] In some embodiments, the total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, 0.08:0.1, or 0.18:0.1.

[0199] In this application, the total mass ratio of oxothiazolidinic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.07-0.15):0.1. The range of 0.07-0.15 can be any value between 0.07 and 0.15; for example, the mass ratio of the total mass of oxothiazolidinic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.07:0.1, 0.08:0.1, 0.09:0.1, 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, or 0.15:0.1.

[0200] In some embodiments, the total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.15:0.1, 0.1:0.1, or 0.07:0.1.

[0201] In this application, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives in the above composition is (0.1-0.2):0.1. For 0.1-0.2, it can encompass any value between 0.1 and 0.2; for example, the total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives can be 0.1:0.1, 0.11:0.1, 0.12:0.1, 0.13:0.1, 0.14:0.1, 0.15:0.1, 0.16:0.1, 0.17:0.1, 0.18:0.1, 0.19:0.1, or 0.2:0.1.

[0202] In some embodiments, the total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives is 0.1:0.1 or 0.2:0.1.

[0203] In this application, the mass ratio of hydroxytyrosol and its derivatives, acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine in the above composition is 0.1:(0.03-3):(0.02-2):(0.03-5):(0.02-6). For 0.03-3, it can cover any value between 0.03 and 3; for 0.02-2, it can cover any value between 0.02 and 2; for 0.03-5, it can cover any value between 0.03 and 5; for 0.02-6, it can cover any value between 0.02 and 6.

[0204] This application provides a cosmetic product comprising the above-described composition for improving the stability of hydroxytyrosol and its derivatives, or the above-described composition, as well as a carrier and / or excipients.

[0205] In this application, the carriers / excipients described in the aforementioned cosmetics are not limited and can be obtained according to methods known to those skilled in the art. For example, emulsifiers may include sodium acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate 80, cetearyl glucoside, cetearyl oleate, sorbitan oleate, arachidonic acid glucoside, etc.

[0206] In some embodiments, the dosage form of the cosmetic includes an emulsified system or a non-emulsified system.

[0207] In some embodiments, the emulsified system includes water, essence, spray, freeze-dried powder, gel, and gel, while the non-emulsified system includes lotion, cream, and eye cream.

[0208] This application provides the above-described compositions for improving the stability of hydroxytyrosol and its derivatives, or the use of the above-described compositions in the preparation of cosmetics.

[0209] Example

[0210] This application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % represents wt%, i.e., weight percentage. Reagents or instruments used, unless otherwise specified, are all commercially available conventional reagent products.

[0211] Example 1: Hydroxytyrosol 0.1g, acetylhydroxyproline 0.1g, add water to 100g.

[0212] Example 2: Hydroxytyrosol 0.1g, oxothiazolidinecarboxylic acid 0.1g, water added to 100g.

[0213] Example 3: Hydroxytyrosol 0.1g, Italian cabbage extract 0.1g, add water to 100g.

[0214] Example 4: Hydroxytyrosol 0.1g, Ergothioneine 0.1g, add water to 100g.

[0215] Example 5: Hydroxytyrosol 0.1g, acetylhydroxyproline 1g, water added to 100g.

[0216] Example 6: Hydroxytyrosol 0.1g, oxothiazolidinecarboxylic acid 1g, water added to 100g.

[0217] Example 7: Hydroxytyrosol 0.1g, Italian cabbage extract 1g, add water to 100g.

[0218] Example 8: Hydroxytyrosol 0.1g, ergothioneine 1g, add water to 100g.

[0219] Example 9: Hydroxytyrosol 0.1g, Acetylhydroxyproline 3g, add water to 100g.

[0220] Example 10: Hydroxytyrosol 0.1g, oxothiazolidinecarboxylic acid 2g, water added to 100g.

[0221] Example 11: Hydroxytyrosol 0.1g, Italian cabbage extract 5g, water added to 100g.

[0222] Example 12: Hydroxytyrosol 0.1g, Ergothioneine 6g, add water to 100g.

[0223] Example 13: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Ergothioneine 0.05g, add water to 100g.

[0224] Example 14: Hydroxytyrosol 0.1g, oxothiazolidine carboxylic acid 0.05g, ergothioneine 0.05g, add water to 100g.

[0225] Example 15: Hydroxytyrosol 0.1g, Italian cabbage extract 0.05g, ergothioneine 0.05g, add water to 100g.

[0226] Example 16: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.05g, water added to 100g.

[0227] Example 17: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Italian cabbage extract 0.05g, add water to 100g.

[0228] Example 18: Hydroxytyrosol 0.1g, oxothiazolidinecarboxylic acid 0.05g, Italian cabbage extract 0.05g, water added to 100g.

[0229] Example 19: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.05g, Ergothioneine 0.05g, add water to 100g.

[0230] Example 20: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Italian cabbage extract 0.05g, Ergothioneine 0.05g, add water to 100g.

[0231] Example 21: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.05g, Italian cabbage extract 0.05g, add water to 100g.

[0232] Example 22: Hydroxytyrosol 0.1g, oxothiazolidine carboxylic acid 0.05g, Italian cabbage extract 0.05g, ergothioneine 0.05g, add water to 100g.

[0233] Example 23: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.1g, Oxothiazolidinylcarboxylic acid 0.1g, Ergothioneine 0.1g, add water to 100g.

[0234] Example 24: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.03g, Ergothioneine 0.02g, add water to 100g.

[0235] Example 25: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Italian cabbage extract 0.03g, Ergothioneine 0.02g, add water to 100g.

[0236] Example 26: Hydroxytyrosol 0.1g, oxothiazolidine carboxylic acid 0.05g, Italian cabbage extract 0.03g, ergothioneine 0.02g, water added to 100g.

[0237] Example 27: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.02g, Italian cabbage extract 0.03g, water added to 100g.

[0238] Example 28: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.05g, Italian cabbage extract 0.05g, Ergothioneine 0.05g, add water to 100g.

[0239] Example 29: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.03g, Oxothiazolidinylcarboxylic acid 0.02g, Italian cabbage extract 0.03g, Ergothioneine 0.02g, add water to 100g.

[0240] Example 30: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.03g, Italian cabbage extract 0.1g, Ergothioneine 0.02g, water added to 100g.

[0241] Example 31: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.02g, Italian cabbage extract 0.03g, Ergothioneine 0.1g, water added to 100g.

[0242] Example 32: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.05g, Oxothiazolidinylcarboxylic acid 0.1g, Italian cabbage extract 0.03g, Ergothioneine 0.02g, water added to 100g.

[0243] Example 33: Hydroxytyrosol 0.1g, Acetylhydroxyproline 0.1g, Oxothiazolidinylcarboxylic acid 0.05g, Italian cabbage extract 0.03g, Ergothioneine 0.02g, water added to 100g.

[0244] Example 34: Hydroxytyrosol butyrate 0.1g, acetylsalicylic acid 0.05g, Italian cabbage extract 0.05g, water added to 100g.

[0245] Example 35: Hydroxytyrosol butyrate 0.1g, acetylhydroxyproline 0.05g, ergothioneine 0.05g, water added to 100g.

[0246] Example 36: Hydroxytyrosol butyrate 0.1g, oxothiazolidine carboxylic acid 0.05g, Italian cabbage extract 0.05g, water added to 100g.

[0247] Example 37: Hydroxytyrosol butyrate 0.1g, oxothiazolidine carboxylic acid 0.05g, ergothioneine 0.05g, water added to 100g.

[0248] Example 38: Hydroxytyrosol butyrate 0.1g, Italian cabbage extract 0.05g, ergothioneine 0.05g, water added to 100g.

[0249] Example 39: Hydroxytyrosol butyrate 0.1g, acetylsalicylic acid 0.05g, Italian cabbage extract 0.03g, ergothioneine 0.02g, water added to 100g.

[0250] Example 40: Hydroxytyrosol butyrate 0.1g, oxothiazolidine carboxylic acid 0.05g, Italian cabbage extract 0.03g, ergothioneine 0.02g, water added to 100g.

[0251] Example 41: Hydroxytyrosol butyrate 0.1g, acetylhydroxyproline 0.03g, oxothiazolidine carboxylic acid 0.02g, Italian cabbage extract 0.02g, ergothioneine 0.03g, water added to 100g.

[0252] Example 42: Hydroxytyrosol butyrate 0.1g, acetylhydroxyproline 0.1g, oxothiazolidine carboxylic acid 0.05g, Italian cabbage extract 0.03g, ergothioneine 0.02g, water added to 100g.

[0253] Example 43: Hydroxytyrosol butyrate 0.1g, acetylhydroxyproline 0.05g, oxothiazolidine carboxylic acid 0.05g, Italian cabbage extract 0.05g, ergothioneine 0.05g, water added to 100g.

[0254] Comparative Example 1: Hydroxytyrosol 0.1g, add water to 100g.

[0255] Comparative Example 2: Hydroxytyrosol butyrate 0.1g, water added to 100g.

[0256] After the above-mentioned embodiments and comparative examples were stirred evenly, they were poured into sample bottles and placed in a 40°C oven. The color changes were observed periodically with the naked eye, and the records were kept for 1 day, 7 days, 14 days, 20 days, 28 days, 40 days, and 60 days.

[0257] In the examples and comparative examples, the colors that were just prepared, and the colors that did not change color, are as follows: Figure 1 As shown, when a color becomes darker, it is considered that the color has changed, such as... Figure 2 , Figure 3 , Figure 4 or Figure 5 As shown.

[0258] The parameters of the above composition and the results of color changes are shown in Table 1. Color change is marked with "×", and no change is marked with "√".

[0259] Table 1

[0260]

[0261]

[0262]

[0263] As can be seen from the above embodiments:

[0264] As can be seen from Examples 1-12, any one of the four compounds, acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine, can improve the stability of hydroxytyrosol. Among them, Example 11 achieved better results, and hydroxytyrosol did not change color until 60 days of observation.

[0265] As can be seen from Examples 13-15, 19-20, 22-26, and 28-33, one, two, or three of the three compounds—acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract—combined with ergothioneine can improve the stability of hydroxytyrosol. All of these examples achieved good results, and hydroxytyrosol did not change color until 60 days of observation.

[0266] As can be seen from Examples 16-18, the combination of two compounds from acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract can improve the stability of hydroxytyrosol. Examples 17 and 18 achieved better results, and hydroxytyrosol did not change color when observed up to 60 days later.

[0267] As can be seen from Examples 21 and 27, the combination of acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract can improve the stability of hydroxytyrosol. Both examples achieved good results, and hydroxytyrosol did not change color until 60 days of observation.

[0268] As can be seen from Examples 34 and 36, the combination of two compounds in acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract can improve the stability of hydroxytyrosol butyrate. Both examples achieved good results, and hydroxytyrosol butyrate did not change color until 60 days of observation.

[0269] As can be seen from Examples 35 and 37-43, the combination of one or two or three compounds from acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract with ergothioneine can improve the stability of hydroxytyrosol butyrate. All of these examples achieved good results, and hydroxytyrosol butyrate did not change color until 60 days of observation.

[0270] Comparative Examples: In Comparative Examples 1 and 2, hydroxytyrosol or hydroxytyrosol butyrate changed color within 1 day without the addition of any component of the composition.

[0271] The description in this disclosure is provided for illustrative and descriptive purposes only and is not intended to be exhaustive or to limit the disclosure to its forms. Many modifications and variations will be apparent to those skilled in the art. The embodiments were chosen and described in order to better illustrate the principles and practical application of this disclosure and to enable those skilled in the art to understand this disclosure and to design various embodiments with various modifications suitable for a particular purpose.

Claims

1. Use of acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and / or ergothioneine in improving the stability of hydroxytyrosol and its derivatives.

2. The use according to claim 1, wherein, The derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate, or hydroxytyrosol glucoside.

3. The use according to claim 1 or 2, wherein, The mass ratios of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract or ergothioneine to hydroxytyrosol and its derivatives are as follows: The mass ratio of acetylated hydroxyproline to hydroxytyrosol and its derivatives is (0.1-3):0.1; The mass ratio of oxothiazolidine carboxylic acid to hydroxytyrosol and its derivatives is (0.1-2):0.1; The mass ratio of Italian cabbage extract to hydroxytyrosol and its derivatives was (0.1-5):0.

1. The mass ratio of ergothioneine to hydroxytyrosol and its derivatives is (0.1-6):0.

1.

4. Use of two, three, or four of the following in improving the stability of hydroxytyrosol and its derivatives: acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine.

5. The use according to claim 4, wherein, The derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate, or hydroxytyrosol glucoside.

6. The use according to any one of claims 4 or 5, wherein, The combination is selected from any one of the following (1) to (10): (1) Acetylhydroxyproline and ergothioneine; or (2) Oxothiazolidinic acid and ergothioneine; or (3) Italian kale extract and ergothioneine; or (4) Acetylhydroxyproline and Italian kale extract; or (5) Oxothiazolidinic acid and Italian kale extract; or (6) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract; or (7) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine; or (8) Acetylhydroxyproline, Italian kale extract, and ergothioneine; or (9) Oxothiazolidinic acid, Italian cabbage extract, and ergothioneine; or (10) Acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine.

7. The use according to any one of claims 4 or 5, wherein, The total mass ratio of acetylated hydroxyproline and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.2):0.

1. The total mass ratio of oxothiazolidine carboxylic acid and ergothioneine to hydroxytyrosol and its derivatives was (0.04-0.2):0.

1. The total mass ratio of Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.05-0.13):0.

1. The total mass ratio of acetylated hydroxyproline and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.06-0.15):0.

1. The total mass ratio of oxothiazolidine carboxylic acid and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.05-0.13):0.

1. The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, and Italian cabbage extract to hydroxytyrosol and its derivatives was (0.08-0.18):0.

1. The total mass ratio of acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.3):0.

1. The total mass ratio of acetylated hydroxyproline, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.08-0.18):0.

1. The total mass ratio of oxothiazolidine carboxylic acid, Italian cabbage extract, and ergothioneine to hydroxytyrosol and its derivatives was (0.07-0.15):0.

1. The total mass ratio of acetylated hydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine to hydroxytyrosol and its derivatives was (0.1-0.2):0.

1.

8. A composition for improving the stability of hydroxytyrosol and its derivatives, wherein, The composition comprises one, two, three, or four of the following: acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract, or ergothioneine.

9. The composition according to claim 8, wherein, The derivative is selected from hydroxytyrosol butyrate, hydroxytyrosol acetate, hydroxytyrosol sulfate, or hydroxytyrosol glucoside.

10. The composition according to any one of claims 8 or 9, wherein, The composition is selected from any one of (1) to (10): (1) Acetylhydroxyproline and ergothioneine; or (2) Oxothiazolidinic acid and ergothioneine; or (3) Italian kale extract and ergothioneine; or (4) Acetylhydroxyproline and Italian kale extract; or (5) Oxothiazolidinic acid and Italian kale extract; or (6) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and Italian kale extract; or (7) Acetylhydroxyproline, oxothiazolidine carboxylic acid, and ergothioneine; or (8) Acetylhydroxyproline, Italian kale extract, and ergothioneine; or (9) Oxothiazolidinic acid, Italian cabbage extract, and ergothioneine; or (10) Acetylhydroxyproline, oxothiazolidine carboxylic acid, Italian cabbage extract and ergothioneine.

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