Compound feed additive for preventing verrucoid protuberances of goose soles and goose feed thereof

Abstract

The invention belongs to the field of feed additives, and particularly relates to a compound feed additive for preventing verruca of goose soles and a goose feed thereof. The compound feed additive can be directly added into growth fattening feed of geese, and the health of goose foot pads is improved through the synergistic effect of multiple components. In the formula, the wheat bran / rice bran promotes generation of intestinal short-chain fatty acid through dietary fibers and enhances synthesis of a biological membrane of an epidermal structure; the garlic powder provides sulfur-containing amino acid and strengthens a keratin cross-linked structure; linoleic acid in DDGS reduces the level of foot inflammatory factors by regulating and controlling metabolism of arachidonic acid; the vitamin B group maintains epidermal differentiation, and the vitamin E / K3 repairs the lipid barrier; the blood powder provides high digestible protein and heme iron, and tissue regeneration is accelerated; zinc sulfate and yeast selenium cooperate to remove oxidation products and inhibit cutin abnormal hyperplasia. According to the scheme, through triple mechanisms of nutrient enrichment, inflammation inhibition and oxidation balance, the occurrence rate of verrucosis of the foot pad is effectively reduced, and meanwhile, the drug residue risk and the physical protection cost are avoided.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of feed additives, and particularly relates to a compound feed additive for preventing warty protrusions on the goose footpads and a goose feed directly added with the compound feed additive. BACKGROUND

[0002] As a common physiological lesion in the field of goose breeding, the formation mechanism and control technology of warty protrusions on the goose footpads (commonly known as goose foot pad wrinkled skin, scientific name toe nodules) have become a key research topic in the industry. The disease mainly manifests as abnormal hyperplasia of the horny layer at the bottom of the goose foot to form warty protrusions, and the pathological causes can be attributed to two core elements: one is mechanical stimulation caused by long-term contact with hard ground, and the other is metabolic abnormalities caused by unbalanced nutrient ratio in the daily diet. Specifically, during the growth and development stage of geese, the foot forms nodular lesions due to long-term bearing of heavy load, which not only affects the standing balance and movement ability of the individual, but also causes pain stress reaction, thereby reducing feed conversion efficiency and affecting meat quality. Such problems have become a technical bottleneck restricting the large-scale development of the goose industry, and have significantly increased the comprehensive cost of breeding enterprises.

[0003] The current prevention and control system mainly relies on dual strategies of physical intervention and chemical control. Physical protection focuses on environmental improvement, and reduces the mechanical stress on the foot by laying cushioning materials and optimizing breeding density; chemical control relies on the addition of anti-inflammatory preparations and antibacterial drugs to relieve secondary infection. However, the existing solutions have significant limitations: physical improvement measures face the implementation dilemma of high maintenance cost of cushioning materials and difficulty in environmental control; chemical intervention has potential problems such as drug residue risk, drug resistance and symptom recurrence, making it difficult to form a long-term prevention and control mechanism. SUMMARY

[0004] In order to solve the problem of warty protrusions on the goose footpads affecting meat quality, the present application provides a compound feed additive for preventing warty protrusions on the goose footpads and a goose feed directly added with the compound feed additive.

[0005] The technical solution provided by the present application is as follows: A compound feed additive for preventing warty protrusions on the goose footpads, according to mass fraction, comprises: 4-8 parts of wheat bran or rice bran, 2-4 parts of garlic powder, 1-2 parts of DDGS, 0.01-0.03 parts of vitamin, 0.2 parts of blood meal and 0.006 parts of zinc sulfate.

[0006] As a further improvement of the present application, the crude protein content in the garlic powder is not less than 12%.

[0007] As a further improvement of the present application, the above-mentioned compound feed additive further comprises yeast selenium, and the selenium content in the yeast selenium is 2000 ppm; the added amount of the yeast selenium in the compound feed additive is 0.25 wt%.

[0008] As a further improvement of the present application, the vitamin is at least one of vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3.

[0009] As a further improvement of the present application, in the compound feed additive, the vitamin B2 is not less than 50 mg, the vitamin B3 is not less than 200 mg, the vitamin B5 is not less than 500 mg, the vitamin B6 is not less than 60 mg, the vitamin B7 is not less than 3 mg, the vitamin E is not less than 300 mg, and the vitamin K3 is not less than 50 mg per kilogram.

[0010] As a further improvement of the present application, the formula of the above-mentioned compound feed additive is as follows: wheat bran or rice bran: garlic powder: DDGS: vitamin: blood meal: zinc sulfate is 4.76:3:2:0.01:0.2:0.006 in mass fraction ratio, and the mass fraction of yeast selenium is 0.25 wt%; wherein, the vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 in the vitamin are in a mass ratio of 5:20:50:6:0.3:30:5; wheat bran or rice bran: garlic powder: DDGS: vitamin: blood meal: zinc sulfate is 4:2:1:0.01:0.2:0.006 in mass fraction ratio, and the mass fraction of yeast selenium is 0.25 wt%; wherein, the vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 in the vitamin are in a mass ratio of 5:20:50:6:0.3:30:5; wheat bran or rice bran: garlic powder: DDGS: vitamin: blood meal: zinc sulfate is 8:4:2:0.03:0.2:0.006 in mass fraction ratio, and the mass fraction of yeast selenium is 0.25 wt%; wherein, the vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 in the vitamin are in a mass ratio of 15:60:150:18:0.9:90:15.

[0011] The present application also provides a preparation method of a compound feed additive for preventing goose foot palm warts. S1: according to a preset formula, a corresponding amount of wheat bran or rice bran, garlic powder and DDGS are weighed, and the above-mentioned materials are uniformly mixed to obtain a mixture one; S2: according to the preset formula, the corresponding mass of blood meal, zinc sulfate and vitamins is weighed, and the above-mentioned materials are uniformly mixed to obtain a mixed material two; S3: the mixed material one and the mixed material two are uniformly mixed to obtain the required compound feed additive.

[0012] As a further improvement of the present application, when the formula contains yeast selenium, step S2 is: According to the preset formula, the corresponding mass of blood meal, zinc sulfate, vitamins and yeast selenium is weighed, and the above-mentioned materials are uniformly mixed to obtain a mixed material two.

[0013] The present application also provides a goose feed, which comprises a main material and any one of the above-mentioned compound feed additives for preventing goose foot pad warty protrusion, and the addition amount of the compound feed additive is 7-10wt%.

[0014] As a further improvement of the present application, the components of the main material include: corn, wheat, rice, soybean meal, rapeseed meal, beer lees, salt and stone powder.

[0015] The technical solution provided by the present application has the following beneficial effects: The present application provides a compound feed additive for preventing goose foot pad warty protrusion, which can be directly added to the fattening feed of geese, and improves the health of goose foot pad through the synergistic effect of multiple components. In the formula, wheat bran or rice bran promotes the synthesis of epidermal structure biofilm by regulating intestinal flora metabolism through dietary fiber, promoting the generation of short-chain fatty acids; garlic powder provides methionine, cysteine and other sulfur-containing amino acids, optimizes the cross-linking structure of keratin, and improves the wear resistance; linoleic acid in DDGS reduces the expression level of foot inflammation factors by regulating arachidonic acid metabolic pathway; vitamin B family cooperates to maintain normal differentiation of epidermal cells, vitamin E and K3 strengthen the integrity of lipid barrier; high-digestibility protein and heme iron in blood meal accelerate the regeneration and repair of foot pad tissue; zinc sulfate and yeast selenium cooperate to remove oxidative stress products and inhibit the excessive proliferation of stratum corneum. Through the triple mechanisms of nutritional regulation, inflammation inhibition and oxidation-reduction balance, the incidence of goose foot pad warty protrusion is effectively reduced, and the residual risk of drug prevention and the cost investment of physical protection measures are avoided. DETAILED DESCRIPTION

[0016] In order to make the purpose, technical scheme and advantages of the present application more clear, the following combined with examples, the present application is further described in detail. It should be understood that the specific examples described herein are only used to explain the present application, and are not used to limit the present application.

[0017] The present application provides a compound feed additive for preventing goose foot pad warty protrusion, and the mass fraction of each raw material component is: wheat bran or rice bran 4-8 parts, garlic powder 2-4 parts, dry distillers grains with solubles (DDGS) 1-2 parts, vitamins 0.01-0.03 parts, blood meal 0.2 parts, and zinc sulfate 0.006 parts.

[0018] In the garlic powder, the content of crude protein is not less than 12%, and the vitamins are at least one of vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E, and vitamin K3.

[0019] In the compound feed additive, the content of vitamin B2 is not less than 50 mg, the content of vitamin B3 is not less than 200 mg, the content of vitamin B5 is not less than 500 mg, the content of vitamin B6 is not less than 60 mg, the content of vitamin B7 is not less than 3 mg, the content of vitamin E is not less than 300 mg, and the content of vitamin K3 is not less than 50 mg.

[0020] In some other embodiments, on the basis of the above formula, the compound feed additive can further include yeast selenium with a selenium content of 2000 ppm, and the addition amount of the yeast selenium in the compound feed additive is 0.25 wt%.

[0021] The compound feed additive can be directly added to the growth and fattening feed of geese, and through the synergistic effect of multiple components, the health of the foot pad of the geese is improved. In the formula, the wheat bran or rice bran regulates the metabolism of intestinal flora through dietary fiber, promotes the generation of short-chain fatty acids, and enhances the synthesis of epidermal structural proteins of the foot pad; the garlic powder provides sulfur-containing amino acids such as methionine and cysteine, optimizes the cross-linking structure of keratin, and improves the wear resistance; the linoleic acid in the DDGS reduces the expression level of foot inflammation factors by regulating the arachidonic acid metabolic pathway; the vitamin B family cooperatively maintains the normal differentiation of epidermal cells, and vitamins E and K3 strengthen the integrity of the lipid barrier; the high-digestibility protein and hematin iron in the blood meal accelerate the regeneration and repair of the foot pad tissue; zinc sulfate and yeast selenium cooperatively scavenge oxidative stress products and inhibit the excessive proliferation of the stratum corneum. Through the triple mechanisms of nutritional regulation, inflammation inhibition, and oxidation-reduction balance, the incidence of warty protrusions on the geese's footpads is effectively reduced, and the residual risk of drug prevention and the cost investment of physical protection measures are avoided.

[0022] As an essential component of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), selenium scavenes free radicals generated by epidermal cell metabolism, reduces the damage of oxidative stress to keratinocytes, cooperatively regulates keratin gene expression with vitamin E, enhances the elasticity of the stratum corneum of the foot pad and the ability to resist mechanical wear, and inhibits the release of inflammatory factors (IL-6, TNF-α); and by enhancing the activity of lysozyme, it inhibits the colonization of pathogens such as Staphylococcus aureus.

[0023] Blood meal contains 83%-86% high-digestibility protein, which provides methionine, cystine and other sulfur-containing amino acids, and promotes the formation of β-keratin cross-linking structure; its heme iron can improve foot blood oxygen saturation, accelerate injury repair and prevent anemic dyskinesia; the immunoglobulin IgY and hemoglobin hydrolytic active peptide contained therein can inhibit the proliferation of pathogenic bacteria in the skin of the foot.

[0024] Zinc is an essential component of metallothionein (MT), which regulates keratinocyte differentiation by activating zinc finger transcription factors, prevents abnormal thickening of the stratum corneum, inhibits the inflammatory pathway of nuclear factor kappa-B (NF-κB), reduces local redness, heat and pain reactions in the foot pad, and in addition, as a coenzyme for various enzymes (such as alkaline phosphatase, DNA polymerase), it can ensure normal metabolism of epidermal cells in the foot, and also enhance the bioavailability of vitamin B group, and synergistically improve skin health.

[0025] Through the synergistic combination of various components, the metabolic balance of the epidermis of the foot of the goose can be systematically improved, preventing the formation of warty protrusions from multiple dimensions such as antioxidant, anti-inflammatory and structural reinforcement.

[0026] The following further illustrates the provided compound feed additive and its preparation method through specific examples.

[0027] Example 1 According to the mass fraction ratio of wheat bran: garlic powder: DDGS: vitamins: blood meal: zinc sulfate being 4.76:3:2:0.01:0.2:0.006, prepare 47.6 kg of wheat bran, 30 kg of garlic powder, 20 kg of DDGS, 5 g of vitamin B2, 20 g of vitamin B3, 50 g of vitamin B5, 6 g of vitamin B6, 0.3 g of vitamin B7, 30 g of vitamin E, 5 g of vitamin K3, 2 kg of blood meal, and 60 g of zinc sulfate; then prepare 250 g of yeast selenium with a mass fraction of 0.25%.

[0028] First, mix the wheat bran, garlic powder and DDGS evenly to obtain a mixture one; then mix the blood meal, yeast selenium, zinc sulfate, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 evenly to obtain a mixture two; finally, mix the mixture one and the mixture two evenly to obtain a uniform mixture.

[0029] After preparation, the compound feed additive is packaged and stored in a well-ventilated and cool place.

[0030] It should be noted that the above mixing process is mixed three times, which has scientific necessity. Blood powder, vitamins, zinc sulfate, yeast selenium and other trace components only account for 2.4% of the total material amount. If directly mixed with dozens of kilograms of material, it is easy to cause stratification due to powder electrostatic adsorption or mechanical vibration. By first mixing blood powder, zinc sulfate, yeast selenium and vitamins, the trace components are pre-mixed in a local area to achieve high concentration, and then mixed with the main raw materials, which can significantly improve the uniformity of the final product.

[0031] Example 2 According to the mass fraction ratio of rice bran: garlic powder: DDGS: vitamin: blood powder: zinc sulfate 4.76:3:2:0.01:0.2:0.006, prepare 47.6 kg of rice bran, 30 kg of garlic powder, 20 kg of DDGS, 5 g of vitamin B2, 20 g of vitamin B3, 50 g of vitamin B5, 6 g of vitamin B6, 0.3 g of vitamin B7, 30 g of vitamin E, 5 g of vitamin K3, 2 kg of blood powder, and 60 g of zinc sulfate; then prepare 250 g of yeast selenium with a mass fraction of 0.25%.

[0032] First, mix the rice bran, garlic powder and DDGS evenly to get mixed material one; then mix the blood powder, yeast selenium, zinc sulfate, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 evenly to get mixed material two; finally, mix the mixed material one and the mixed material two evenly to get the uniform mixed material.

[0033] After preparation, the compound feed additive is packed and stored in a well-ventilated and cool place.

[0034] Example 3 According to the mass fraction ratio of wheat bran: garlic powder: DDGS: vitamin: blood powder: zinc sulfate 4:2:1:0.01:0.2:0.006, prepare 40 kg of wheat bran, 20 kg of garlic powder, 10 kg of DDGS, 5 g of vitamin B2, 20 g of vitamin B3, 50 g of vitamin B5, 6 g of vitamin B6, 0.3 g of vitamin B7, 30 g of vitamin E, 5 g of vitamin K3, 2 kg of blood powder, and 60 g of zinc sulfate; then prepare 180 g (approximate value) of yeast selenium with a mass fraction of 0.25%.

[0035] First, mix the wheat bran, garlic powder and DDGS evenly to get mixed material one; then mix the blood powder, yeast selenium, zinc sulfate, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 evenly to get mixed material two; finally, mix the mixed material one and the mixed material two evenly to get the uniform mixed material.

[0036] After preparation, the compound feed additive is packed and stored in a ventilated and cool place.

[0037] Example 4 According to the mass fraction ratio of wheat bran: garlic powder: DDGS: vitamin: blood meal: zinc sulfate being 8:4:2:0.03:0.2:0.006, prepare 80 kg of wheat bran, 40 kg of garlic powder, 20 kg of DDGS, 15 g of vitamin B2, 60 g of vitamin B3, 150 g of vitamin B5, 18 g of vitamin B6, 0.9 g of vitamin B7, 90 g of vitamin E, 15 g of vitamin K3, 2 kg of blood meal, and 60 g of zinc sulfate; and then prepare 357 g (take the approximate value) of yeast selenium according to a mass fraction of 0.25wt%.

[0038] First, mix the wheat bran, garlic powder and DDGS uniformly to obtain a mixture one; then mix the blood meal, yeast selenium, zinc sulfate, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E and vitamin K3 uniformly to obtain a mixture two; finally, mix the mixture one and the mixture two uniformly to obtain a uniformly mixed material.

[0039] After preparation, the compound feed additive is packed and stored in a ventilated and cool place.

[0040] The above examples prepare a series of compound feed additives for preventing the warty protrusions on the goose's foot by different preparation methods. The difference between the different preparation methods is only that the auxiliary materials and the mass fraction ratio of each component are different.

[0041] In order to further determine the preventive effect of the compound feed additives obtained in the above examples on the warty protrusions on the goose's foot, three groups of comparative experiments are also set up in this example to verify.

[0042] Comparative Experiment 1 (1) Experimental setup The powder / pellet feed prepared from corn, wheat, soybean meal, rapeseed meal, beer dregs, salt and stone powder is used as the control group, and the test group is the control group with the addition of 10wt% of the compound feed additive of Example 1. There is also a farm group (corn + wheat meal pellet feed). 1200 60-day-old Wuxi white geese in the wheat area (half male and half female) are selected, with an average initial weight of about 3152.6±25.8g. A completely randomized block design is used to divide them into 3 groups, with 4 replicates in each group, 100 in each replicate (half male and half female), and a total of 12 independent pens. The experiment includes a 5-day pre-feeding period, and the formal test lasts from 65 days to 135 days.

[0043] (2) The experimental results are shown in Table 1 below: Table 1 Effect of the additive of Example 1 on the warty protrusions on the feet of Wuxi white geese in the wheat area Group Number of male geese Proportion of male geese Number of female geese Proportion of female geese Test group 1.75 ± 0.13 a ]] 1.86 ± 0.17 a ]] 1.87 ± 0.15 a ]] 1.96 ± 0.18 a ]] Control group 6.75 ± 0.65 b ]] 7.50 ± 0.85 b ]] 7.25 ± 0.72 b ]] 7.88 ± 0.85 b ]] Farm group 13.50 ± 1.60 c ]] 14.28 ± 1.73 c ]] 15.15 ± 1.5 c ]] 16.93 ± 2.23 c ]] Note: The same column data in the table with different letters on the right shoulder indicates significant difference (P<0.05), and the letters between the letters indicate extremely significant difference (P<0.01), and the same letters indicate no significant difference; The "proportion of male geese" and "proportion of female geese" in the table refer to the percentage of the number of occurrences in each repeat to the number of test geese in each repeat.

[0044] According to the test data in Table 1, it is shown that the incidence of foot pad warts of Maiquanzi Wanxi white geese fed with the compound feed additive of Example 1 of the present application is significantly improved: the incidence of the test group (male geese 1.86±0.17%, female geese 1.96±0.18%) is reduced by 75.3-75.9% (P<0.05) compared with the control group (male geese 7.50±0.85%, female geese 7.88±0.85%), and by 87.0-88.4% (P<0.01) compared with the farm group (male geese 14.28±1.73%, female geese 16.93±2.23%), which confirms that the additive has a significant foot pad health protection effect. It is worth noting that under the same feeding conditions, the incidence of male geese is generally lower than that of female geese, which may be related to the difference in thickness of the epidermal cuticle of male individuals and the regulation of androgen levels on collagen metabolism. The high incidence of the farm group highlights the significant defects in the nutritional balance of conventional diets, while the present application can systematically improve the epidermal microenvironment of the foot pad by constructing a "fiber reinforcement-anti-inflammatory repair-oxidation balance" trinity nutritional intervention system, and realize the breakthrough of traditional breeding from the perspective of feed nutrition.

[0045] Comparative Experiment 2 (1) Experimental setup The powder / granular feed prepared from corn, wheat, soybean meal, rapeseed meal, beer dregs, salt and stone powder is used as the control group, the test group I is the control group diet added with 10wt% of the compound feed additive of Example 1, and the test group II is the control group diet added with 10wt% of the compound feed additive of Example 2, and a farm group (corn+wheat coarse powder pellet feed) is also set. 1568 60-day-old Hall-Dobaji geese (half male and half female) with an average initial weight of about 3815.7±52.3g are selected, and a completely randomized design is used to divide them into 4 groups, 4 repeats per group, 98 (half male and half female) per repeat, a total of 16 independent pens. The test includes a 5-day pre-feeding period, and the formal test lasts from 65 days to 135 days.

[0046] (2) The experimental results are shown in Table 2 as follows: Table 2 Effect of additives of Example 1 and Example 2 on foot pad warts of Hall-Dobaji geese Group Number of male geese Proportion of male geese Number of female geese Proportion of female geese Test group I 1.70 ± 0.10 a ]] 1.87 ± 0.12 a ]] 1.79 ± 0.10 a ]] 1.88 ± 0.13 a ]] Test group II 1.29 ± 0.05 a ]] 1.40 ± 0.07 a ]] 1.70 ± 0.08 a ]] 1.79 ± 0.12 a <!-- 5 -->]]> Control group 5.35 ± 0.26 b ]] 5.87 ± 0.35 b ]] 5.55 ± 0.27 b ]] 5.95 ± 0.32 b ]] Farm group 13.55 ± 1.90 c ]] 14.10 ± 2.35 c ]] 14.25 ± 1.90 c ]] 14.96 ± 2.50 c ]] Note: The same column data in the table indicates significant difference (P<0.05) with different letters on the right shoulder, and extremely significant difference (P<0.01) with different letters, and no significant difference with the same letter; The "proportion of male geese" and "proportion of female geese" in the table refer to the percentage of the number of occurrences in each repeat to the number of test geese in each repeat.

[0047] As shown by the results in Table 2, the composite feed additive of the present application Example 1 and Example 2 can significantly reduce the incidence of warty protrusions on the feet of Hallabagi geese. The incidence of the test group I and the test group II is significantly lower than that of the control group and the farm group, which confirms that the additive has a significant preventive effect. The incidence of the test group II is lower than that of the test group I, which shows that rice chaff contains more nutrients to resist the occurrence of warty protrusions on the feet than bran; gender difference analysis shows that the incidence of male geese is lower than that of female geese, which is related to the mechanism of keratin layer thickening mediated by androgens. The incidence of the farm group is as high as 14.96%-15.10%, which confirms the nutritional imbalance problem of corn-wheat basic feed, and the additive effectively improves the health of the keratin layer by supplementing key nutrients such as zinc and vitamin B group. In addition, compared with Wanxi white geese in the same type of test, the basic incidence of Hallabagi geese group is lower, which shows that this breed may have an advantage in foot epidermal structure.

[0048] Comparative Experiment 3 (1) Experimental setup The powder / granular feed prepared from corn, rice, soybean meal, rapeseed meal, beer dregs, salt and stone powder was used as the control group, the test group I was prepared by adding 10wt% of the composite feed additive of Example 1 to the control group diet, and the test group II was prepared by adding 10wt% of the composite feed additive of Example 2 to the control group diet, and a farm group (corn + rice coarse powder granular feed) was also set up. 1568 60-day-old rice area Wanxi white goose growing geese (half male and half female) with an average initial weight of about 3363.5±26.5g were selected, and a completely randomized block design was used to divide them into 4 groups, 4 repeats in each group, 98 geese in each repeat (half male and half female), a total of 16 independent pens. The test included a 5-day pre-feeding period, and the formal test lasted from 65 days to 135 days.

[0049] (2) The experimental results are shown in Table 3 as follows: Table 3 Effect of the additive of Example 1 and Example 2 on the warty protrusions on the feet of rice area Wanxi white geese Group Number of male geese Proportion of male geese Number of female geese Proportion of female geese Test group I 1.70 ± 0.15 a ]] 2.07 ± 0.11 a ]] 2.05 ± 0.18 a ]] 2.36 ± 0.17 a ]] Test group II 1.51 ± 0.13 a ]] 1.60 ± 0.10 a ]] 1.70 ± 0.12 a ]] 1.79 ± 0.14 a ]] Control group 6.30 ± 0.74 b ]] 7.25 ± 1.02 b ]] 6.80 ± 0.85 b ]] 7.82 ± 1.20 b ]] Farm group 12.75 ± 1.40 c ]] 13.46 ± 1.83 c ]] 13.20 ± 1.75 c ]] 14.13 ± 1.75 c ]] Note: The same column data in the table indicates significant difference (P<0.05) with different letters on the right shoulder, and extremely significant difference (P<0.01) with different letters, and no significant difference with the same letter; The "proportion of male geese" and "proportion of female geese" in the table refer to the percentage of the number of occurrences in each repeat to the number of test geese in each repeat.

[0050] As shown in Table 3, after using the composite feed additive of the present application, the incidence of warty protrusions on the feet of Wanxi white geese in the rice area was significantly lower than that of the control group and the farm group. Among them, the effect of test group II was better, which further verified that the feed formula based on rice and its by-products (such as rice bran) could better adapt to the physiological needs of Wanxi white geese in the rice area compared to the northern wheat area (comparative experiment 1). Using feed containing the composite feed additive of Example 2 can further reduce the incidence of warty protrusions on the feet of Wanxi white geese in the rice area, and it is speculated that the mechanism may be closely related to the regional adaptability of Wanxi white geese in the rice area to rice-based feed (such as specific intestinal flora, keratin layer metabolism regulation, etc.), and the high incidence of the farm group highlights the structural defects of traditional feed in the proportion of crude protein, trace elements, vitamins and fiber content.

[0051] In summary, the present application provides a composite feed additive for preventing warty protrusions on the feet of geese, which can be directly added to the growth and fattening feed of geese to improve the health of the foot pad of geese through the synergistic effect of multiple components. In the formula, wheat bran or rice bran promotes the synthesis of the epidermal structure of the foot pad by regulating the metabolism of intestinal flora, promoting the generation of short-chain fatty acids, and enhancing the synthesis of the epidermal structure of the foot pad; garlic powder provides sulfur-containing amino acids such as methionine and cysteine, optimizes the cross-linking structure of keratin, and enhances wear resistance; linoleic acid in DDGS reduces the expression level of foot inflammation factors by regulating arachidonic acid metabolism pathways; vitamin B family maintains normal differentiation of epidermal cells, vitamin E and K3 strengthen the integrity of the lipid barrier; high-digestibility protein and heme iron in blood meal accelerate the regeneration and repair of foot pad tissue; zinc sulfate and selenium yeast synergistically scavenge oxidative stress products and inhibit the excessive proliferation of the keratin layer. Through the triple mechanisms of nutritional regulation, inflammation inhibition and oxidation-reduction balance, the incidence of warty protrusions on the feet of geese is effectively reduced, while the residual risk of drug prevention and the cost investment of physical protection measures are avoided.

[0052] The above only describes the preferred embodiments of the present application and should not be used to limit the present application, and any modifications, equivalent replacements and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A compound feed additive for preventing gouty hock warts, characterized by: It comprises, in parts by mass: 4-8 parts of wheat bran or rice bran, 2-4 parts of garlic powder, 1-2 parts of DDGS, 0.01-0.03 parts of vitamins, 0.2 parts of blood meal, and 0.006 parts of zinc sulfate.

2. The compound feed additive for preventing the verruciform protrusions on the goose's footpads according to claim 1, characterized in that: The crude protein content in the garlic powder is not less than 12%.

3. The compound feed additive for preventing the verruciform protrusions on the goose's footpads according to claim 1, characterized in that: It further comprises yeast selenium, the selenium content in the yeast selenium is 2000 ppm, and the added amount of the yeast selenium in the compound feed additive is 0.25 wt%.

4. The compound feed additive for preventing the verruciform protrusions on the goose's footpads according to claim 1, characterized in that: The vitamins are at least one of vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin E, and vitamin K3.

5. The compound feed additive for preventing the verruciform protrusions on the goose's footpads according to claim 4, characterized in that: In each kilogram of the compound feed additive, the vitamin B2 is not less than 50 mg, the vitamin B3 is not less than 200 mg, the vitamin B5 is not less than 500 mg, the vitamin B6 is not less than 60 mg, the vitamin B7 is not less than 3 mg, the vitamin E is not less than 300 mg, and the vitamin K3 is not less than 50 mg.

6. The compound feed additive for preventing goose footpalm warts according to claim 1, characterized in that: The mass ratio of the wheat bran or rice bran: garlic powder: DDGS: vitamins: blood meal: zinc sulfate is 4.76:3:2:0.01:0.2:0.006, the mass fraction of the yeast selenium is 0.25 wt%, and the vitamins B2, B3, B5, B6, B7, E, and K3 in the vitamins are in a mass ratio of 5:20:50:6:0.3:30:5; Or, the mass ratio of the wheat bran or rice bran: garlic powder: DDGS: vitamins: blood meal: zinc sulfate is 4:2:1:0.01:0.2:0.006, the mass fraction of the yeast selenium is 0.25 wt%, and the vitamins B2, B3, B5, B6, B7, E, and K3 in the vitamins are in a mass ratio of 5:20:50:6:0.3:30:5; Or, the mass ratio of the wheat bran or rice bran: garlic powder: DDGS: vitamins: blood meal: zinc sulfate is 8:4:2:0.03:0.2:0.006, the mass fraction of the yeast selenium is 0.25 wt%, and the vitamins B2, B3, B5, B6, B7, E, and K3 in the vitamins are in a mass ratio of 15:60:150:18:0.9:90:

15.

7. A method for preparing the compound feed additive for preventing gouty-hoof warty protrusions according to any one of claims 1 to 6, characterized in that, It comprises the following steps: S1: according to a preset formula, the corresponding mass of the wheat bran or rice bran, garlic powder, and DDGS is weighed, and the above materials are uniformly mixed to obtain a mixture one; S2: according to the preset formula, the corresponding mass of blood meal, zinc sulfate and vitamins are weighed, and the above materials are uniformly mixed to obtain a mixed material two; S3: the mixed material one and the mixed material two are uniformly mixed to obtain the required compound feed additive.

8. The compound feed additive for preventing goose footpalm warts according to claim 7, characterized in that, When the formula contains yeast selenium, step S2 is: According to the preset formula, the corresponding mass of blood meal, zinc sulfate, vitamins and yeast selenium are weighed, and the above materials are uniformly mixed to obtain a mixed material two.

9. A goose feed, characterized by: It comprises a main material and a compound feed additive for preventing goose foot palm warty protrusion according to any one of claims 1 to 6, and the addition amount of the compound feed additive is 7-10wt%.

10. The goose feed according to claim 9, characterized in that: The components of the main material include corn, wheat, rice, soybean meal, rapeseed meal, beer lees, salt and stone powder.