Compound oral liquid helpful for maintaining healthy level of blood pressure and preparation method of compound oral liquid

Abstract

The invention belongs to the technical field of functional food, and particularly relates to a compound oral liquid beneficial to maintaining the healthy level of blood pressure and a preparation method thereof.The compound oral liquid is prepared from, by weight, 4-12 parts of Shanxi mature vinegar, 3-12 parts of folium cortex eucommiae and 3-12 parts of folium apocyni veneti. The traditional Chinese medicine composition contains various antihypertensive active substances such as melanoidins and ligustrazine, two traditional Chinese medicinal materials such as folium cortex eucommiae and folium apocyni veneti which have an antihypertensive effect are matched, the traditional Chinese medicinal materials are rich in antihypertensive components such as flavonoid and phenolic acid, the optimal proportion is obtained through multiple tests, and the efficacy of cooperatively promoting and maintaining the blood pressure health level is achieved. A series of complications caused by hypertension are relieved, the healthy level of blood pressure can be maintained and tends to be stable, and the three components have a remarkable synergistic interaction effect according to the prescription range and the preparation method disclosed by the patent.

Description

Technical Field

[0001] This invention relates to the field of functional food technology, specifically to a compound oral liquid that helps maintain healthy blood pressure levels and its preparation method. Background Technology

[0002] High blood pressure is a major risk factor for premature death and disability, and a global health problem. While traditional drug treatments can effectively control blood pressure, long-term use may lead to a range of side effects. Functional foods, on the other hand, can not only alleviate symptoms and improve physical condition, but also do not cause significant side effects.

[0003] Shanxi aged vinegar is a famous Chinese vinegar, not only known for its unique flavor but also for its numerous health benefits. Many of its health-promoting factors are being continuously discovered, including its ability to lower blood lipids, lower blood pressure, protect the liver, and provide antioxidant effects. Eucommia ulmoides leaves contain flavonoids, lignans, and other chemical components, exhibiting pharmacological effects such as antioxidant activity, blood pressure reduction, neuroprotection, and bone protection. Compared to most antihypertensive drugs, Eucommia ulmoides leaves are safer and more effective, showing promising application prospects. Apocynum venetum leaves are also rich in rutin, minerals, and other nutrients, especially flavonoids. They have long been used in traditional Chinese medicine to treat hypertension and depression, making them a natural health-promoting plant.

[0004] In preliminary experimental studies, Shanxi aged vinegar, Eucommia ulmoides leaves, and Apocynum venetum leaves have been shown to have a synergistic effect. Shanxi aged vinegar is rich in polyphenols and flavonoids, possessing antioxidant properties, regulating intestinal flora, and assisting in lowering blood pressure and lipids, providing a solid foundation for metabolic regulation. Lignans in Eucommia ulmoides leaves, such as pinoresinol diglucoside, enhance the body's tolerance to blood pressure fluctuations. Flavonoids in Apocynum venetum leaves can dilate blood vessels, reduce blood flow resistance, and alleviate symptoms such as headaches and tinnitus caused by primary hypertension, exhibiting a significant blood pressure-lowering effect. When combined, these three ingredients can improve the body's internal metabolic environment and alleviate symptoms caused by hypertension. The acidity of Shanxi aged vinegar can also increase the solubility of some active ingredients, enhancing the absorption rate of the effective components, while masking the bitterness of Eucommia ulmoides and Apocynum venetum leaves. However, when used alone or in combination, the effect of maintaining healthy blood pressure levels is less than ideal. Based on Shanxi aged vinegar, and scientifically combined with Eucommia ulmoides leaves and Apocynum venetum leaves, the development of health food products that help maintain healthy blood pressure levels has significant social value and practical significance. Summary of the Invention

[0005] The purpose of this invention is to provide a compound oral liquid that helps maintain healthy blood pressure levels and its preparation method, so as to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a compound oral liquid that helps maintain healthy blood pressure levels, which is made from the following raw materials in parts by weight: 4-12 parts of Shanxi aged vinegar, 3-12 parts of Eucommia ulmoides leaves, and 3-12 parts of Apocynum venetum leaves.

[0007] Preferably, the compound oral liquid is made from the following raw materials in parts by weight: 12 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

[0008] A method for preparing a compound oral liquid that helps maintain healthy blood pressure levels, the specific steps of which are as follows:

[0009] Step 1: Preparation of concentrated solution A: Shanxi aged vinegar is concentrated under reduced pressure to obtain concentrated solution A;

[0010] Step 2: Preparation of concentrated solution B: Eucommia ulmoides leaves and Apocynum venetum leaves are decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B;

[0011] Step 3: Preparation of compound oral liquid: Combine concentrated solutions A and B, add appropriate excipients, mix well, filter, sterilize and package to obtain compound oral liquid.

[0012] Preferably, the vacuum concentration conditions in steps one and two are: maintaining a vacuum level of -0.06 to -0.09 MPa and a heating temperature of 50 to 95°C.

[0013] Preferably, in step one, the relative density of concentrated liquid A is 1.15-1.20, and it is concentrated to 0.3-0.8 times the original volume of Shanxi aged vinegar.

[0014] Preferably, the decoction extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step two are as follows: weigh Eucommia ulmoides leaves and Apocynum venetum leaves in a 1:1 ratio, use water extraction method, add water to soak at a material-to-liquid ratio of 1:10-20 kg:L, decoct at 90-110℃ for 30-80 minutes, filter after decoction, decoct 1-4 times, and collect and combine the filtrates C.

[0015] Preferably, in step two, the relative density of concentrate B is 1.10-1.15, and it is concentrated to 0.01-0.07 times the original volume of filtrate C.

[0016] Preferably, the excipients added in step three are selected from one or more of the following: honey, steviol glycosides, mogrosides, maltitol, fructooligosaccharides, xylitol, xylooligosaccharides, sucrose, aspartame, citric acid, flavoring, glycerin, xanthan gum, sodium carboxymethyl cellulose, β-cyclodextrin, polyethylene glycol, and sodium bicarbonate.

[0017] Preferably, in step three, the mixture is sterilized and packaged using pasteurization, high-temperature steam sterilization, or ultraviolet sterilization.

[0018] Compared with the prior art, the beneficial effects of the present invention are:

[0019] 1) This invention is based on Shanxi aged vinegar, which contains a variety of antihypertensive active substances such as melanin and ligustrazine. It is combined with two Chinese medicinal herbs, Eucommia ulmoides leaves and Apocynum venetum leaves, which are known to have antihypertensive effects. They are rich in antihypertensive components such as flavonoids and phenolic acids. After multiple experiments, the optimal ratio was obtained to synergistically promote the maintenance of healthy blood pressure levels and reduce a series of complications caused by hypertension. It helps to maintain healthy blood pressure levels and stabilize them. The three ingredients, according to the prescription scope and preparation method disclosed in this patent, have a significant synergistic effect.

[0020] 2) This invention specifies a concentration range for Shanxi aged vinegar and traditional Chinese medicine extract, that is, to a range of relative densities. On the one hand, this maximizes the enrichment of the effective components of the raw materials and avoids the loss of effective components; on the other hand, it avoids the adverse effects on the human body caused by excessive acidity and improves the safety and stability of the product; thirdly, concentrating Shanxi aged vinegar and traditional Chinese medicine extract to the relative density range disclosed in this patent is a necessary condition for the three to exert synergistic effects. Within this relative density range, the synergistic effect of the substances is optimal and the effect is most significant.

[0021] 3) The recommended dosage and method of administration in this invention not only avoid the irritation of acetic acid to the human gastric mucosa, making it more acceptable to the user, but also improve the utilization rate of its active ingredients, ensuring that the health benefits are fully realized.

[0022] 4) This invention is not only suitable for middle-aged and elderly people with hypertension, but also for young people who need to maintain healthy blood pressure levels as the age range of people with hypertension continues to expand, providing a variety of product choices for consumers. Attached Figure Description

[0023] Figure 1 This is a flowchart of the preparation steps of the present invention. Detailed Implementation

[0024] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0026] Please see Figure 1 The present invention provides a technical solution:

[0027] A compound oral liquid that helps maintain healthy blood pressure levels is made from the following ingredients in parts by weight: 4-12 parts Shanxi aged vinegar, 3-12 parts Eucommia ulmoides leaves, and 3-12 parts Apocynum venetum leaves.

[0028] The compound oral liquid is made from the following ingredients in parts by weight: 12 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

[0029] A method for preparing a compound oral liquid that helps maintain healthy blood pressure levels, the specific steps of which are as follows:

[0030] Step 1: Preparation of concentrated solution A: Shanxi aged vinegar is concentrated under reduced pressure to obtain concentrated solution A;

[0031] Step 2: Preparation of concentrated solution B: Eucommia ulmoides leaves and Apocynum venetum leaves are decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B;

[0032] Step 3: Preparation of compound oral liquid: Combine concentrated solutions A and B, add appropriate excipients, mix well, filter, sterilize and package to obtain compound oral liquid.

[0033] The vacuum concentration conditions in steps one and two are as follows: maintain a vacuum level of -0.06 to -0.09 MPa and maintain a heating temperature of 50 to 95°C.

[0034] In step one, the relative density of concentrated liquid A is 1.15-1.20, and it is concentrated to 0.3-0.8 times the original volume of Shanxi aged vinegar.

[0035] The recommended daily dosage of this compound oral solution for maintaining healthy blood pressure levels is 20-60 mL, taken twice daily with a 10-12 hour interval between doses.

[0036] The decoction and extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step two are as follows: weigh Eucommia ulmoides leaves and Apocynum venetum leaves in a 1:1 ratio, use water extraction method, add water to soak at a material-to-liquid ratio of 1:10-20 kg:L, decoct at 90-110℃ for 30-80 minutes, filter after decoction, decoct 1-4 times, and collect and combine the filtrates C.

[0037] In step two, the relative density of concentrate B is 1.10-1.15, and it is concentrated to 0.01-0.07 times the original volume of filtrate C.

[0038] In step three, the excipients added are selected from one or more of the following: honey, steviol glycosides, mogrosides, maltitol, fructooligosaccharides, xylitol, xylooligosaccharides, sucrose, aspartame, citric acid, flavoring, glycerin, xanthan gum, sodium carboxymethyl cellulose, β-cyclodextrin, polyethylene glycol, and sodium bicarbonate.

[0039] In step three, the mixture is sterilized and packaged using pasteurization, high-temperature steam sterilization, or ultraviolet sterilization.

[0040] Example 1:

[0041] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0042] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 12 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

[0043] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0044] (1) Shanxi aged vinegar is concentrated by vacuum concentration to obtain concentrated liquid A.

[0045] (2) Eucommia ulmoides leaves and Apocynum venetum leaves were decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0046] The vacuum concentration conditions in steps (1) and (2) are: maintaining a vacuum of -0.07 MPa and a heating temperature of 75°C.

[0047] In step (1), the relative density of concentrate A is 1.16, and it is concentrated to 0.5 times the original volume of Shanxi aged vinegar.

[0048] The decoction extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step (2) are as follows: Eucommia ulmoides leaves and Apocynum venetum leaves are weighed in a 1:1 ratio, and water extraction is used. Water is added at a material-to-liquid ratio of 1:14 kg:L for soaking. The mixture is then decocted at 100℃ for 50 min, filtered, and decocted twice. The filtrates C are collected and combined. The relative density of the resulting concentrated solution B is 1.11. The solution is concentrated to 0.04 times the original volume of filtrate C.

[0049] (3) Mix the concentrated solutions A and B thoroughly and filter them. Then sterilize and package them to obtain the compound oral solution.

[0050] In step (3), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0051] The dosage of the compound oral solution is twice a day, once in the morning and once in the evening, 20mL each time.

[0052] Example 2:

[0053] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0054] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 8 parts Shanxi aged vinegar, 5 parts Eucommia ulmoides leaves, and 5 parts Apocynum venetum leaves.

[0055] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0056] (1) Shanxi aged vinegar is concentrated by vacuum concentration to obtain concentrated liquid A.

[0057] (2) Eucommia ulmoides leaves and Apocynum venetum leaves were decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0058] The vacuum concentration conditions in steps (1) and (2) are: maintaining a vacuum of -0.07 MPa and a heating temperature of 75°C.

[0059] In step (1), the relative density of concentrate A is 1.16, and it is concentrated to 0.5 times the original volume of Shanxi aged vinegar.

[0060] The decoction extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step (2) are as follows: Eucommia ulmoides leaves and Apocynum venetum leaves are weighed in a 1:1 ratio, and water extraction is used. Water is added at a material-to-liquid ratio of 1:14 kg:L for soaking. The mixture is then decocted at 100℃ for 50 min, filtered, and decocted twice. The filtrates C are collected and combined. The relative density of the resulting concentrated solution B is 1.11. The solution is concentrated to 0.04 times the original volume of filtrate C.

[0061] (3) Mix concentrated solutions A and B together, add appropriate excipients, filter, sterilize and package to obtain compound oral liquid.

[0062] In step (3), an appropriate amount of honey is added to adjust the taste of the oral liquid.

[0063] In step (3), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0064] The dosage of the compound oral solution is twice a day, once in the morning and once in the evening, 20mL each time.

[0065] Example 3:

[0066] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0067] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 6 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

[0068] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0069] (1) Shanxi aged vinegar is concentrated by vacuum concentration to obtain concentrated liquid A.

[0070] (2) Eucommia ulmoides leaves and Apocynum venetum leaves were decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0071] The vacuum concentration conditions in steps (1) and (2) are: maintaining a vacuum of -0.08 MPa and a heating temperature of 85°C.

[0072] In step (1), the relative density of concentrate A is 1.16, and it is concentrated to 0.5 times the original volume of Shanxi aged vinegar.

[0073] The decoction extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step (2) are as follows: Eucommia ulmoides leaves and Apocynum venetum leaves are weighed in a 1:1 ratio, and water extraction is used. Water is added at a material-to-liquid ratio of 1:10 kg:L for soaking. The mixture is then decocted at 90℃ for 30 minutes, filtered, and decocted three times. The filtrates C are collected and combined. The relative density of the resulting concentrated solution B is 1.11. The solution is concentrated to 0.04 times the original volume of filtrate C.

[0074] (3) Mix concentrated solutions A and B together, add appropriate excipients, filter, sterilize and package to obtain compound oral liquid.

[0075] In step (3), an appropriate amount of honey is added to adjust the taste of the oral liquid.

[0076] In step (3), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0077] The dosage of the compound oral solution is twice a day, once in the morning and once in the evening, 20mL each time.

[0078] Example 4:

[0079] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0080] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 6 parts Shanxi aged vinegar and 6 parts Apocynum venetum leaves.

[0081] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0082] (1) Shanxi aged vinegar is concentrated by vacuum concentration to obtain concentrated liquid A.

[0083] (2) The leaves of Apocynum venetum were boiled, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0084] The vacuum concentration conditions in steps (1) and (2) are: maintaining a vacuum of -0.07 MPa and a heating temperature of 75°C.

[0085] In step (1), the relative density of concentrate A is 1.16, and it is concentrated to 0.5 times the original volume of Shanxi aged vinegar.

[0086] The extraction conditions for Apocynum venetum leaves in step (2) are as follows: weigh the Apocynum venetum leaves as required, use water extraction, soak in water at a material-to-liquid ratio of 1:14 kg:L, decoct at 100℃ for 50 min, filter after decoction, decoct twice, and collect and combine the filtrates C. The relative density of the resulting concentrated solution B is 1.11, and it is concentrated to 0.04 times the original volume of filtrate C.

[0087] (3) Mix concentrated solutions A and B together, add appropriate excipients, filter, sterilize and package to obtain compound oral liquid.

[0088] In step (3), an appropriate amount of honey is added to adjust the taste of the oral liquid.

[0089] In step (3), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0090] The dosage of the compound oral solution is twice a day, once in the morning and once in the evening, 20mL each time.

[0091] Example 5:

[0092] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0093] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 6 parts Eucommia ulmoides leaves and 6 parts Apocynum venetum leaves.

[0094] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0095] (1) Eucommia ulmoides leaves and Apocynum venetum leaves were decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0096] The vacuum concentration conditions in step (1) are: maintaining a vacuum of -0.07 MPa and a heating temperature of 75°C.

[0097] The decoction extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step (1) are as follows: Eucommia ulmoides leaves and Apocynum venetum leaves are weighed in a 1:1 ratio, and water extraction is used. Water is added at a material-to-liquid ratio of 1:14 kg:L for soaking. The mixture is then decocted at 100℃ for 50 min, filtered, and decocted twice. The filtrates C are collected and combined. The relative density of the resulting concentrated solution B is 1.11. The solution is concentrated to 0.04 times the original volume of filtrate C.

[0098] (2) Add an appropriate amount of excipients to concentrated solution B, mix well and filter, then sterilize and package to obtain compound oral solution.

[0099] In step (2), an appropriate amount of honey is added to adjust the taste of the oral liquid.

[0100] In step (2), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0101] The dosage of the compound oral solution is twice a day, once in the morning and once in the evening, 20mL each time.

[0102] Example 6:

[0103] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0104] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 7 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

[0105] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0106] (1) Shanxi aged vinegar is vinegar stock solution A.

[0107] (2) Eucommia ulmoides leaves and Apocynum venetum leaves were decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0108] The decoction and extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step (2) are as follows: weigh Eucommia ulmoides leaves and Apocynum venetum leaves in a 1:1 ratio, use water extraction method, add water to soak at a material-liquid ratio of 1:14 kg:L, decoct at 100℃ for 50 min, filter after decoction, decoct twice, and collect and combine the filtrate C.

[0109] The vacuum concentration conditions in step (2) are: maintaining a vacuum of -0.07 MPa and a heating temperature of 75°C. The resulting concentrate B has a relative density of 1.09 and is concentrated to 0.04 times the original volume of the filtrate C.

[0110] (3) Mix the vinegar stock solution A and the concentrated solution B, add an appropriate amount of excipients, mix well and filter, then sterilize and package to obtain the compound oral liquid.

[0111] In step (3), an appropriate amount of honey is added to adjust the taste of the oral liquid.

[0112] In step (3), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0113] The dosage of the compound oral solution is twice a day, once in the morning and once in the evening, 20mL each time.

[0114] Example 7:

[0115] Preparation of compound oral solutions that help maintain healthy blood pressure levels;

[0116] A compound oral liquid that helps maintain healthy blood pressure levels is mainly made from the following ingredients in parts by weight: 6 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

[0117] The steps for preparing the compound oral liquid using the above raw materials are as follows:

[0118] (1) Shanxi aged vinegar is concentrated by vacuum concentration to obtain concentrated liquid A.

[0119] (2) Eucommia ulmoides leaves and Apocynum venetum leaves were decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B.

[0120] The vacuum concentration conditions in steps (1) and (2) are: maintaining a vacuum of -0.07 MPa and a heating temperature of 75°C.

[0121] In step (1), the relative density of concentrate A is 1.16, and it is concentrated to 0.5 times the original volume of Shanxi aged vinegar.

[0122] The decoction extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step (2) are as follows: Eucommia ulmoides leaves and Apocynum venetum leaves are weighed in a 1:1 ratio, and water extraction is used. Water is added at a material-to-liquid ratio of 1:14 kg:L for soaking. The mixture is then decocted at 100℃ for 50 min, filtered, and decocted twice. The filtrates C are collected and combined. The relative density of the resulting concentrated solution B is 1.11. The solution is concentrated to 0.04 times the original volume of filtrate C.

[0123] (3) Mix the concentrates A and B properly, add an appropriate amount of excipients, filter, sterilize and package to obtain the compound oral liquid.

[0124] In step (3), an appropriate amount of honey is added to adjust the taste of the oral liquid.

[0125] In step (3), the mixture is sterilized and packaged using pasteurization to ensure that the compound oral liquid meets the national safety requirements.

[0126] The dosage of the compound oral solution is once a day, 40 mL each time.

[0127] Test Implementation Example:

[0128] This invention provides a compound oral liquid that helps maintain healthy blood pressure levels. To demonstrate its effectiveness, the compound oral liquid provided in the examples was evaluated for efficacy, and the results are as follows:

[0129] Ten normal Wister rats and 80 spontaneously hypertensive rats (SHR), all male, SPF grade, 10 weeks old, weighing 180-220g, were selected as experimental animals and fed with standard rat feed. The SHR rats were randomly divided into a model group and experimental groups 1-7, with 10 rats in each group. Experimental groups 1-7 were given the compound oral solution prepared in Examples 1-7, calculated based on a daily intake of 40mL for a 70kg adult (conversion factor 7: 40×7 / 70 = 4mL / kg / day). The subsequent dosage for rats was 4mL / kg / day. Except for experimental group 7, which was administered once daily, the other groups were administered the solution twice daily (morning and evening). The normal group and model group were given an equal volume of physiological saline by gavage. The administration was continued for 4 weeks. Blood pressure was measured in rats before and after the experiment using the rat tail artery pressure measurement method, with three repeated measurements and the average value taken. The results are shown in Tables 1-2.

[0130] Table 1. Effects on systolic blood pressure in rats (X±S)

[0131]

[0132]

[0133] Note: Compared with the model group, *** indicates that the experimental group P<0.001, and **** indicates that the experimental group P<0.0001.

[0134] Table 2 Effects on diastolic blood pressure in rats (X±S)

[0135]

[0136]

[0137] Note: Compared with the model group, *** indicates that the experimental group P<0.001, and **** indicates that the experimental group P<0.0001.

[0138] As shown in Tables 1 and 2, the systolic and diastolic blood pressure of the normal Wistar rats were significantly lower than those of the other groups before and after 4 weeks of administration. Before administration, there were no significant differences in systolic and diastolic blood pressure among the model group and the experimental groups. After 4 weeks of administration, compared with the model group, experimental groups 4-6 showed no significant difference in systolic and diastolic blood pressure, indicating that removing Shanxi aged vinegar, removing some traditional Chinese medicine, and changes in concentration and relative density greatly affected the efficacy in maintaining healthy blood pressure levels. The systolic and diastolic blood pressure of experimental groups 1-3 and 7 were significantly reduced, with experimental group 1 showing the best effect. Experimental groups 2, 3, and 7 still showed significant differences compared with experimental group 1 (P < 0.05), indicating poor efficacy. Therefore, changes in the prescription, preparation method, and administration method all adversely affected the efficacy, with the unconcentrated vinegar and changes in the concentration and relative density of the traditional Chinese medicine solution having the greatest impact. From the above, it can be concluded that Example 1 has the best effect in maintaining healthy blood pressure levels.

[0139] In summary, the compound oral liquid of this invention has a significant effect on maintaining healthy blood pressure levels, is highly safe, and can be well applied to the development and production of functional foods that help maintain healthy blood pressure levels.

[0140] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or basic characteristics. Therefore, the embodiments should be considered exemplary and non-limiting in all respects. The scope of the invention is defined by the appended claims rather than the foregoing description. Therefore, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention, and no reference numerals in the claims should be construed as limiting the scope of the claims.

[0141] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A compound oral solution that helps maintain healthy blood pressure levels, characterized in that, This compound oral liquid is made from the following ingredients in parts by weight: 4-12 parts Shanxi aged vinegar, 3-12 parts Eucommia ulmoides leaves, and 3-12 parts Apocynum venetum leaves.

2. The compound oral liquid according to claim 1, characterized in that: The compound oral liquid is made from the following ingredients in parts by weight: 12 parts Shanxi aged vinegar, 6 parts Eucommia ulmoides leaves, and 6 parts Apocynum venetum leaves.

3. A method for preparing a compound oral liquid as described in any one of claims 1-2 that helps maintain healthy blood pressure levels, characterized in that: The specific steps for preparing this compound oral liquid are as follows: Step 1: Preparation of concentrated solution A: Shanxi aged vinegar is concentrated under reduced pressure to obtain concentrated solution A; Step 2: Preparation of concentrated solution B: Eucommia ulmoides leaves and Apocynum venetum leaves are decocted, filtered, and concentrated under reduced pressure to obtain concentrated solution B; Step 3: Preparation of compound oral liquid: Combine concentrated solutions A and B, add appropriate excipients, mix well, filter, sterilize and package to obtain compound oral liquid.

4. The method for preparing a compound oral liquid that helps maintain healthy blood pressure levels according to claim 3, characterized in that: The vacuum concentration conditions in steps one and two are as follows: maintain a vacuum level of -0.06 to -0.09 MPa and maintain a heating temperature of 50 to 95°C.

5. The method for preparing a compound oral liquid that helps maintain healthy blood pressure levels according to claim 3, characterized in that: In step one, the relative density of concentrated liquid A is 1.15-1.20, and it is concentrated to 0.3-0.8 times the original volume of Shanxi aged vinegar.

6. The method for preparing a compound oral liquid that helps maintain healthy blood pressure levels according to claim 3, characterized in that: The decoction and extraction conditions for Eucommia ulmoides leaves and Apocynum venetum leaves in step two are as follows: weigh Eucommia ulmoides leaves and Apocynum venetum leaves in a 1:1 ratio, use water extraction method, add water to soak at a material-to-liquid ratio of 1:10-20 kg:L, decoct at 90-110℃ for 30-80 minutes, filter after decoction, decoct 1-4 times, and collect and combine the filtrates C.

7. The method for preparing a compound oral liquid that helps maintain healthy blood pressure levels according to claim 3, characterized in that: In step two, the relative density of concentrate B is 1.10-1.15, and it is concentrated to 0.01-0.07 times the original volume of filtrate C.

8. The method for preparing a compound oral liquid that helps maintain healthy blood pressure levels according to claim 3, characterized in that: In step three, the excipients added are selected from one or more of the following: honey, steviol glycosides, mogrosides, maltitol, fructooligosaccharides, xylitol, xylooligosaccharides, sucrose, aspartame, citric acid, flavoring, glycerin, xanthan gum, sodium carboxymethyl cellulose, β-cyclodextrin, polyethylene glycol, and sodium bicarbonate.

9. The method for preparing a compound oral liquid that helps maintain healthy blood pressure levels according to claim 3, characterized in that: In step three, the mixture is sterilized and packaged using pasteurization, high-temperature steam sterilization, or ultraviolet sterilization.

Images