Compound nutrient as well as preparation method and application thereof

Abstract

The invention relates to nutritional products, and discloses a compound nutrient as well as a preparation method and application thereof. The nutrient beverage contains blueberry anthocyanin, silymarin, theanine, algal oil DHA (docosahexaenoic acid) and phosphatidylserine. The method comprises the following steps: (1) mixing a raw material I to obtain a solid mixture; mixing the raw materials II to obtain a liquid mixture; mixing the solid mixture and the liquid mixture; the raw material I contains blueberry anthocyanin, silymarin and theanine, and the raw material II contains algae oil DHA (docosahexaenoic acid) and phosphatidylserine. The compound nutrient has a good blood fat reducing effect, is safe and does not have toxic or side effects.

Description

TECHNICAL FIELD

[0001] The present application relates to a nutritional product, in particular to a compound nutrient and a preparation method and application thereof. BACKGROUND

[0002] Hyperlipidemia is medically referred to as hyperlipidemia, which is a metabolic disease caused by abnormal increase of lipid components such as cholesterol and triglyceride in blood. It can cause blood viscosity, blood flow slowing down, and atherosclerosis, which is an important risk factor for cardiovascular and cerebrovascular diseases (such as coronary heart disease, cerebral infarction, etc.). Because there are usually no obvious symptoms in the early stage, it can silently damage the health of blood vessels. The current market's auxiliary blood lipid-lowering products, although the drugs have curative effect, but there are liver damage, muscle pain and other side effects, long-term use risk is larger; health care products are relatively safe, but the blood lipid-lowering effect is not satisfactory, and cannot meet the actual needs of patients, it is urgent to develop safe and efficient auxiliary blood lipid-lowering products. SUMMARY

[0003] The purpose of the present application is to overcome the problems of the prior art that the blood lipid-lowering drugs have liver damage, muscle pain and other side effects, and the health care products have unsatisfactory blood lipid-lowering effect, and to provide a compound nutrient and a preparation method and application thereof. The compound nutrient has good blood lipid-lowering effect and is safe and non-toxic side effect.

[0004] In order to achieve the above-mentioned purpose, the first aspect of the present application provides a compound nutrient, which contains blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine.

[0005] Preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.2.

[0006] Further preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine and the DHA algal oil is 1:0.83-1:1.3-1.5.

[0007] Preferably, the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin is 1:0.6-0.95:1.1-1.35:0.37-0.45.

[0008] Further preferably, the mass ratio of the theanine and the algal oil DHA is 1:1.2-1.3.

[0009] More preferably, the mass ratio of the phosphatidylserine and the algal oil DHA is 1:1.2-1.85.

[0010] Preferably, the mass ratio of the phosphatidylserine and the silymarin is 1:0.4-0.75.

[0011] Preferably, the complex nutrient further contains microcrystalline cellulose.

[0012] Further preferably, the content of the microcrystalline cellulose is 10-15wt% based on the total mass of the complex nutrient.

[0013] The second aspect of the present application provides a preparation method of a complex nutrient, which comprises the following steps: (1) mixing raw material I to obtain a solid mixture; mixing raw material II to obtain a liquid mixture; The raw material I contains blueberry anthocyanins, silymarin and theanine, and the raw material II contains algal oil DHA and phosphatidylserine; (2) mixing the solid mixture and the liquid mixture.

[0014] Preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.2.

[0015] Further preferably, the mass ratio of the blueberry anthocyanins, the algal oil DHA and the silymarin is 1:1.25-1.5:0.8-1.

[0016] Preferably, the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin is 1:0.6-0.95:1.1-1.35:0.37-0.45.

[0017] Further preferably, the mass ratio of the theanine and the algal oil DHA is 1:1.2-1.3.

[0018] More preferably, the mass ratio of the phosphatidylserine and the algal oil DHA is 1:1.2-1.85.

[0019] Preferably, the mass ratio of the phosphatidylserine and the silymarin is 1:0.4-0.75.

[0020] Preferably, the raw material I further contains microcrystalline cellulose.

[0021] Further preferably, the mass ratio of the blueberry anthocyanins and the microcrystalline cellulose is 1:0.4-0.8.

[0022] Preferably, in step (1), the mixing II is under the condition that the temperature is 50-60℃.

[0023] Preferably, before the mixing I of step (1), the raw material I is broken into particles.

[0024] Preferably, the particle size of the particles is less than or equal to 180 μm.

[0025] The third aspect of the present application provides a use of the above-mentioned complex nutrient or the complex nutrient prepared by the above-mentioned preparation method as a health care product or a drug for lowering blood lipid.

[0026] Through the above technical solution, the complex nutrient provided by the present application contains blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine, and through the interaction between the blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine, the advantages of each component are fully exerted, and the effect of lowering blood lipid can be significantly improved, and the complex nutrient has good application as a health care product or a drug for lowering blood lipid. Moreover, the complex nutrient also has the effects of antioxidant and promoting the development of nervous system, and can comprehensively improve the health status of human body, reduce the risk of complications such as cardiovascular diseases, and has high health application value. The above-mentioned substances can be used as components in health care products, and have relatively small toxic and side effects and high safety. BRIEF DESCRIPTION OF DRAWINGS

[0027] Fig. 1 is the total cholesterol level of mice in the example group, the comparative example group, the normal group and the high-fat model group; Fig. 2 is the triglyceride level of mice in the example group, the comparative example group, the normal group and the high-fat model group; Fig. 3 is the low-density lipoprotein cholesterol level of mice in the example group, the comparative example group, the normal group and the high-fat model group. DETAILED DESCRIPTION

[0028] The endpoints of the ranges and any values disclosed herein are not limited to the precise values stated. The endpoints of the ranges and any values are provided as approximations. The endpoints of the ranges and any values are understood to be approximate, and in actual practice, individual values will typically be understood to be within a range of values that are near to the stated value. Any numerical value, however, can be exact, where expressly stated.

[0029] The first aspect of the present application provides a complex nutrient containing blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine.

[0030] The inventors found in the research process that the compound nutrients contain blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine, and through the interaction between the blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine, the advantages of each component can be fully played, and the blood lipid-lowering effect can be significantly improved, so that the compound nutrients have better application as blood lipid-lowering health products or blood lipid-lowering drugs. Moreover, the compound nutrients also have the effects of antioxidation and promoting the development of the nervous system, and can comprehensively improve the health status of the human body and reduce the risk of complications such as cardiovascular diseases, and have high health application value. In addition, the blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin and theanine in the compound nutrients can be used as components in health products, and have relatively small toxic and side effects and high safety.

[0031] Preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.2. The blueberry anthocyanins, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine have better interaction effect at the above mass ratio, and thus the blood lipid-lowering effect of the compound nutrients can be further improved.

[0032] According to the present application, the mass ratio of the blueberry anthocyanins and the phosphatidylserine can be 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1.0, 1:1.1, or any value within the range formed by any two of the above ratios. The mass ratio of the blueberry anthocyanins and the algal oil DHA can be 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, or any value within the range formed by any two of the above ratios. The mass ratio of the blueberry anthocyanins and the silymarin can be 1:0.42, 1:0.44, 1:0.46, 1:0.48, 1:0.50, 1:0.52, 0.53, or any value within the range formed by any two of the above ratios. The mass ratio of the blueberry anthocyanins and the theanine can be 1:1, 1:1.02, 1:1.04, 1:1.06, 1:1.08, 1:1.1, 1:1.12, 1:1.14, 1:1.16, 1:1.18, 1:1.2, or any value within the range formed by any two of the above ratios.

[0033] From the perspective of further improving the blood lipid-lowering effect of the compound nutrients, it is further preferred that the mass ratio of the blueberry anthocyanins, the phosphatidylserine and the DHA algal oil is 1:0.83-1:1.3-1.5.

[0034] Preferably, the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin is 1:0.6-0.95:1.1-1.35::0.37-0.45. Controlling the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin within the above range, the hypolipidemic effect of the compound nutrient can be further improved through the interaction of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin with specific mass ratios.

[0035] According to the present application, the mass ratio of the theanine and the phosphatidylserine can be 1:0.6, 1:0.65, 1:0.7, 1:0.75, 1:0.8, 1:0.85, 1:0.9, 1:0.95, or any value within the range formed by any two of the above ratios. The mass ratio of the theanine and the algal oil DHA can be 1:1.1, 1:1.15, 1:1.2, 1:1.25, 1:1.3, 1:1.35, or any value within the range formed by any two of the above ratios. The mass ratio of the theanine and the silymarin can be 1:0.37, 1:0.39, 1:0.41, 1:0.43, 1:0.45, or any value within the range formed by any two of the above ratios.

[0036] Preferably, the mass ratio of the theanine and the algal oil DHA is 1:1.2-1.3, which can be 1:1.2, 1:1.22, 1:1.24, 1:1.26, 1:1.28, 1:1.3, or any value within the range formed by any two of the above ratios. Controlling the mass ratio of the theanine and the algal oil DHA within the above range, the hypolipidemic effect of the compound nutrient can be further improved through the interaction between the theanine and the algal oil with specific mass ratios.

[0037] Preferably, the compound nutrient further contains microcrystalline cellulose. Through the interaction between the microcrystalline cellulose and the blueberry anthocyanin, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine, the hypolipidemic effect of the compound nutrient can be further improved. In consideration of further improving the hypolipidemic effect of the compound nutrient, it is further preferred that the content of the microcrystalline cellulose is 10-15wt% based on the total mass of the compound nutrient, which can be 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, or any value within the range formed by any two of the above values.

[0038] The second aspect of the present application provides a preparation method of a compound nutrient, which comprises the following steps: (1) mixing raw material I to obtain a solid mixture; (2) mixing raw material II to obtain a liquid mixture; The raw material I contains blueberry anthocyanins, silymarin and theanine, and the raw material II contains algal oil DHA and phosphatidylserine; (2) mixing the solid mixture and the liquid mixture.

[0039] The composite nutrient prepared by the preparation method has blueberry anthocyanins, silymarin, algal oil DHA, phosphatidylserine and theanine, and the advantages of each component are fully exerted through the interaction of the blueberry anthocyanins, silymarin, algal oil DHA, phosphatidylserine and theanine, so that the lipid-lowering effect can be significantly improved, and the composite nutrient has good application as a lipid-lowering health product or a lipid-lowering drug.

[0040] Preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.2. The blueberry anthocyanins, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine have better interaction effect at the above mass ratio, so that the lipid-lowering effect of the composite nutrient can be further improved.

[0041] According to the present application, the mass ratio of the blueberry anthocyanins and the phosphatidylserine can be 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1.0, 1:1.1, or any value within the range formed by any two of the above ratios. The mass ratio of the blueberry anthocyanins and the algal oil DHA can be 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, 1:1.6, or any value within the range formed by any two of the above ratios. The mass ratio of the blueberry anthocyanins and the silymarin can be 1:0.42, 1:0.44, 1:0.46, 1:0.48, 1:0.50, 1:0.52, 0.53, or any value within the range formed by any two of the above ratios. The mass ratio of the blueberry anthocyanins and the theanine can be 1:1, 1:1.02, 1:1.04, 1:1.06, 1:1.08, 1:1.1, 1:1.12, 1:1.14, 1:1.16, 1:1.18, 1:1.2, or any value within the range formed by any two of the above ratios.

[0042] Further preferably, the mass ratio of the blueberry anthocyanins, the algal oil DHA and the silymarin is 1:1.25-1.5:0.8-1, in consideration of further improving the lipid-lowering effect of the composite nutrient.

[0043] Further preferably, the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin is 1:0.6-0.95:1.1-1.35::0.37-0.45. Controlling the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin within the above range, the hypolipidemic effect of the complex nutrients can be further improved through the interaction of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin with specific mass ratios According to the present application, the mass ratio of the theanine and the phosphatidylserine can be 1:0.6, 1:0.65, 1:0.7, 1:0.75, 1:0.8, 1:0.85, 1:0.9, 1:0.95, or any value within the range formed by any two of the above ratios. The mass ratio of the theanine and the algal oil DHA can be 1:1.1, 1:1.15, 1:1.2, 1:1.25, 1:1.3, 1:1.35, or any value within the range formed by any two of the above ratios. The mass ratio of the theanine and the silymarin can be 1:0.37, 1:0.39, 1:0.41, 1:0.43, 1:0.45, or any value within the range formed by any two of the above ratios.

[0044] Preferably, the mass ratio of the theanine and the algal oil DHA is 1:1.2-1.3, which can be 1:1.2, 1:1.22, 1:1.24, 1:1.26, 1:1.28, 1:1.3, or any value within the range formed by any two of the above ratios. Controlling the mass ratio of the theanine and the algal oil DHA within the above range, the hypolipidemic effect of the complex nutrients can be further improved through the interaction between the theanine and the algal oil with specific mass ratios.

[0045] Preferably, the raw material I further contains microcrystalline cellulose. Through the interaction between the microcrystalline cellulose and the blueberry anthocyanin, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine, the hypolipidemic effect of the complex nutrients can be further improved. In consideration of further improving the hypolipidemic effect of the complex nutrients, further preferably, the mass ratio of the blueberry anthocyanin and the microcrystalline cellulose is 1:0.4-0.8, which can be 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, or any value within the range formed by any two of the above ratios.

[0046] Preferably, in step (1), the mixing II is performed under conditions including at least: a temperature of 50-60℃, which can be 50℃, 52℃, 54℃, 56℃, 58℃, 60℃, or any value within the range formed by any two of these values. Under the above conditions, the phosphatidylserine has a better dissolution effect in the raw material II, which in turn enables the mixing of the algal oil DHA and the phosphatidylserine to be more uniform.

[0047] Preferably, before the mixing of step (1), the raw material I is broken into particles. Further preferably, the particle size of the particles is less than or equal to 180 μm. Controlling the particle size of the particles within the above range can result in better mixing of the raw material I.

[0048] Preferably, in step (2), the mixing is performed by adding the solid mixture into the liquid mixture under stirring. Further preferably, the stirring is performed at a speed of 40-50 rpm for 12-18 min.

[0049] Preferably, the method further comprises granulating the mixture obtained in step (2). Further preferably, the granulation is performed in a swing granulator. The diameter of the granules obtained is 0.8-1.2 mm, further preferably 1 mm.

[0050] Preferably, the method further comprises drying the granules obtained in the above granulation. Further preferably, the drying is performed at a temperature of 50-60 °C for 30-40 min. During the drying, the moisture content of the sample can be detected at intervals, and the drying is stopped when the moisture content is reduced to 4-5%. After the drying is completed, the sample can be sieved again to remove the agglomerates, and the sieve used for the sieving is a 18-mesh sieve (pore size 1 mm).

[0051] Preferably, the composite nutrient can be encapsulated to obtain a capsule, or compressed to obtain a tablet. The obtained capsule and / or tablet can be stored in the dark. In one specific embodiment of the present application, the capsule is encapsulated using a gelatin capsule shell.

[0052] According to one particularly preferred embodiment of the present application, a method for preparing a nutrient beverage is provided, comprising the following steps: The blueberry anthocyanins, silymarin, theanine and microcrystalline cellulose are broken into particles, sieved through a 89-mesh sieve (particle size ≤180 μm), and then mixed uniformly to obtain a solid powder mixture.

[0053] The algal oil DHA and phosphatidylserine are placed in a constant temperature water bath at 55±2 °C, and stirred and melted to form a uniform liquid, to obtain a liquid mixture.

[0054] The mass ratio of the blueberry anthocyanin, the phosphatidylserine, the algal oil DHA, the silymarin, the theanine and the microcrystalline cellulose is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.2:0.4-0.8; the mass ratio of the theanine, the phosphatidylserine, the algal oil DHA and the silymarin is 1:0.6-0.95:1.1-1.35:0.37-0.45.

[0055] (2) The solid powder mixture is slowly added into the liquid mixture, and a kneader is used to stir for 15 minutes at a speed of 45 rpm to form a soft material. The soft material is granulated by a swing granulator through an 18-mesh screen (pore size 1 mm) to obtain wet granules.

[0056] (3) The wet granules are transferred to a belt dryer for drying, the drying temperature is controlled at 55±2℃, the running speed of the mesh belt is 1±0.2 m / min, and the drying time is 30 minutes. During the drying process, the moisture content is detected every 10 minutes, and the drying is stopped when the moisture content is reduced to 4%-5%. The dried granules are granulated again through an 18-mesh screen to remove the agglomerates, and the granules with good fluidity are obtained.

[0057] (4) A semi-automatic capsule filling machine is used to quantitatively fill the granules into No. 0 gelatin capsule shells, and the net weight of each capsule is 500±20 mg. The capsule body cap is locked tightly, the filled capsules are placed into brown glass bottles, food-grade silica gel desiccant and iron-based oxygen scavenger are added into each bottle. The bottle opening is sealed with an aluminum foil gasket, and the plastic bottle cap is screwed and then labeled.

[0058] In addition, the blueberry anthocyanin, the phosphatidylserine, the algal oil DHA, the silymarin and the theanine in the above-mentioned specific mass ratio have a better synergistic effect, can further improve the efficacy of each component itself, and can significantly improve the blood lipid-lowering effect, and have a good application in blood lipid-lowering health products or blood lipid-lowering drugs.

[0059] The application will be described in detail through the following examples. In the following examples, the blueberry anthocyanin is purchased from Shaanxi Qingya Biological Technology Co., Ltd., the silymarin is purchased from Shaanxi Yunhe Biological Technology Co., Ltd., the theanine and curcumin are purchased from Shaanxi Baichuan Biological Technology Co., Ltd., the phosphatidylserine is purchased from Changzhou Mujia Food Ingredients Co., Ltd., the algal oil DHA is purchased from Zhishuo Biological Technology Co., Ltd., the microcrystalline cellulose is purchased from Jiangsu Shunying Biological Technology Co., Ltd., the black nightshade fruit anthocyanin is purchased from Shaanxi Juntaibio Technology Co., Ltd., the taurine is purchased from Henan Anrui Biological Technology Co., Ltd., the olive oil is purchased from Shandong Fuzekang Edible Oil Co., Ltd., and the glutamine is purchased from Mingrui Group Co., Ltd.

[0060] In the following examples, 1 mass part is 1 g.

[0061] Example 1 The raw material components are: blueberry anthocyanins 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 24 parts by mass, phosphatidylserine 16 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0062] The preparation method is: (1) The blueberry anthocyanins, silymarin, theanine, and microcrystalline cellulose are crushed, passed through a 89-mesh sieve (particle size ≤180 μm), and then uniformly mixed to obtain a solid powder mixture.

[0063] The algal oil DHA and phosphatidylserine are placed in a constant-temperature water bath at 55±2°C and stirred and melted until uniform liquid, forming a liquid mixture.

[0064] (2) The solid powder mixture is slowly added to the liquid mixture, and a kneader is used to stir at a speed of 45 rpm for 15 minutes to form a soft material. The soft material is granulated by passing through an 18-mesh sieve (pore size 1 mm) using a swing granulator to obtain wet granules.

[0065] (3) The wet granules are transferred to a belt dryer, and the drying temperature is controlled at 55±2°C, the web belt running speed is 1±0.2 m / min, and the drying time is 30 minutes. During the drying process, the moisture content is detected every 10 minutes, and when the moisture content is reduced to 4-5 wt%, the drying is stopped. The dried granules are again sieved through an 18-mesh sieve to remove lumps, and granules with good flowability are obtained.

[0066] (4) A semi-automatic capsule filling machine is used to quantitatively fill the granules into No. 0 gelatin capsule shells, with a net weight of 500±20 mg per capsule. The capsule body cap is tightly locked, and the filled capsules are placed in a brown glass bottle, 1 package (1 g / 30 capsules) of food-grade silica gel desiccant and 1 package (50 mg / capsule) of iron-based oxygen scavenger are added to each bottle. The bottle opening is sealed with an aluminum foil gasket, and the plastic bottle cap is screwed on and labeled.

[0067] Example 2 Compared with Example 1, the difference is that the raw material components are: blueberry anthocyanins 14 parts by mass, silymarin 6 parts by mass, theanine 16 parts, algal oil DHA 18 parts by mass, phosphatidylserine 15 parts by mass, and microcrystalline cellulose 11 parts by mass.

[0068] Example 3 Compared with Example 1, the difference is that the raw material components are: blueberry anthocyanins 18 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, phosphatidylserine 11 parts by mass, and microcrystalline cellulose 8 parts by mass.

[0069] Example 4 Comparative Example 1

[0070] Example 5 Comparative Example 1 except that the raw material components were as follows: blueberry anthocyanin 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 22 parts by mass, phosphatidylserine 15 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0071] Example 6 Comparative Example 3 except that the raw material components did not contain microcrystalline cellulose.

[0072] Example 7 Comparative Example 1 except that the raw material components were as follows: blueberry anthocyanin 12 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 24 parts by mass, phosphatidylserine 16 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0073] Example 8 Comparative Example 3 except that the raw material components were as follows: blueberry anthocyanin 20 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, phosphatidylserine 11 parts by mass, and microcrystalline cellulose 8 parts by mass.

[0074] Comparative Example 1 Comparative Example 1 except that the raw material components were as follows: silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, phosphatidylserine 16 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0075] Comparative Example 2 Comparative Example 1 except that the raw material components were as follows: blueberry anthocyanin 15 parts by mass, algal oil DHA 20 parts by mass, theanine 18 parts, phosphatidylserine 16 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0076] Comparative Example 3 Comparative Example 1 except that the raw material components were as follows: blueberry anthocyanin 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, phosphatidylserine 16 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0077] Comparative Example 4 Comparative Example 1 except that the raw material components were as follows: blueberry anthocyanin 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, and microcrystalline cellulose 10 parts by mass.

[0078] Comparative Example 5 Comparing with Example 1, the difference is that the raw material components: black wolfberry anthocyanins 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, phosphatidylserine 16 parts by mass, microcrystalline cellulose 10 parts by mass.

[0079] Comparative Example 6 Comparing with Example 1, the difference is that the raw material components: blueberry anthocyanins 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, taurine 16 parts by mass, microcrystalline cellulose 10 parts by mass.

[0080] Comparative Example 7 Comparing with Example 1, the difference is that the raw material components: blueberry anthocyanins 15 parts by mass, silymarin 8 parts by mass, theanine 18 parts, olive oil 20 parts by mass, phosphatidylserine 16 parts by mass, microcrystalline cellulose 10 parts by mass.

[0081] Comparative Example 8 Comparing with Example 1, the difference is that the raw material components: blueberry anthocyanins 15 parts by mass, curcumin 8 parts by mass, theanine 18 parts, algal oil DHA 20 parts by mass, phosphatidylserine 16 parts by mass, microcrystalline cellulose 10 parts by mass.

[0082] Comparative Example 9 Comparing with Example 1, the difference is that the raw material components: blueberry anthocyanins 15 parts by mass, silymarin 8 parts by mass, glutamine 18 parts, olive oil 20 parts by mass, phosphatidylserine 16 parts by mass, microcrystalline cellulose 10 parts by mass.

[0083] Test Example The high-fat feed is composed of basic feed 58.8wt%, lard 10wt%, fructose 20wt%, egg yolk powder 10wt%, cholesterol 1wt% and sodium cholate 0.2wt%. The basic feed is purchased from Syngenta.

[0084] After 77 selected 8-week-old male C57BL / 6J mice (22±2g) were adaptively fed for one week under the same conditions, free drinking and eating, keeping natural light, no adverse factors, they were randomly divided into two groups, 72 in the first group and 5 in the second group. The first group was fed with high-fat feed and the second group was fed with ordinary feed. After continuous feeding for 4 weeks, the blood lipids of the mice were measured, and the mice with serum total cholesterol content higher than 3 mmol / L were considered as successful construction of hyperlipidemia mouse model.

[0085] The first group of 72 mice successfully constructed hyperlipidemia model were randomly divided into 18 groups. One group was used as a hyperlipidemia model control group, and the remaining groups corresponded to the hypolipidemic products of Examples 1-8 and Comparative Examples 1-9, respectively. The hypolipidemic products were dissolved in water and administered by gavage, with a dose of 150 mg / kg body weight once a day. The control group was fed with the same volume of pure water. After 18 days of continuous administration, the blood lipid status of the mice was determined (the mice were normally fed with ordinary feed during the administration period). The data obtained are shown in Table 1. Figs. 1-3 and Table 1.

[0086] Table 1

[0087] As can be seen from the results in Table 1, the nutrient drinks of Examples 1-8 have lower total cholesterol content, triglyceride content and low-density lipoprotein cholesterol content than all the comparative examples 1-9, indicating that the components in the nutrient drinks provided by the present application cooperate with each other to have good hypolipidemic efficacy.

[0088] The preferred embodiments of the present application are described in detail above, but the present application is not limited thereto. Within the technical concept of the present application, various simple modifications can be made to the technical solutions of the present application, including the combination of various technical features in any other suitable manner. These simple modifications and combinations should also be considered as disclosed by the present application and fall within the protection scope of the present application.

Claims

1. A compound nutrient, characterized in that, This complex nutrient contains blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin, and theanine.

2. The compound nutrient according to claim 1, characterized in that, The mass ratio of the blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin, and theanine is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.

2. Preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine, and the DHA algal oil is 1:0.83-1:1.3-1.

5.

3. The compound nutrient according to claim 1 or 2, characterized in that, The mass ratio of theanine, phosphatidylserine, algal oil DHA, and silymarin is 1:0.6-0.95:1.1-1.35:0.37-0.45; Preferably, the mass ratio of theanine to algal oil DHA is 1:1.2-1.3; Preferably, the mass ratio of phosphatidylserine to algal oil DHA is 1:1.2-1.85; Preferably, the mass ratio of phosphatidylserine to silymarin is 1:0.4-0.

75.

4. The compound nutrient according to any one of claims 1 to 3, characterized in that, This complex nutrient also contains microcrystalline cellulose; Preferably, the content of microcrystalline cellulose is 10-15 wt%, based on the total mass of the compound nutrients as 100%.

5. A method for preparing a compound nutrient, characterized in that, The method includes the following steps: (1) Mix raw material I to obtain a solid mixture; Mix raw material II to obtain a liquid mixture; Raw material I contains blueberry anthocyanins, silymarin and theanine, and raw material II contains algal oil DHA and phosphatidylserine; (2) Mix the solid mixture and the liquid mixture.

6. The preparation method according to claim 5, characterized in that, The mass ratio of the blueberry anthocyanins, phosphatidylserine, algal oil DHA, silymarin, and theanine is 1:0.6-1.1:1.1-1.6:0.42-0.53:1-1.

2. Preferably, the mass ratio of the blueberry anthocyanins, the phosphatidylserine, and the DHA algal oil is 1:0.83-1:1.3-1.

5.

7. The preparation method according to claim 6, characterized in that, The mass ratio of theanine, phosphatidylserine, algal oil DHA, and silymarin is 1:0.6-0.95:1.1-1.35:0.37-0.45; Preferably, the mass ratio of theanine to algal oil DHA is 1:1.2-1.3; Preferably, the mass ratio of phosphatidylserine to algal oil DHA is 1:1.2-1.85; Preferably, the mass ratio of phosphatidylserine to silymarin is 1:0.4-0.

75.

8. The preparation method according to any one of claims 5 to 7, characterized in that, The raw material I also contains microcrystalline cellulose; Preferably, the mass ratio of blueberry anthocyanins to microcrystalline cellulose is 1:0.4-0.

8.

9. The preparation method according to any one of claims 5 to 7, characterized in that, In step (1), the conditions for mixing II include at least: a temperature of 50-60°C; Preferably, before mixing I in step (1), the raw material I is crushed into particles; Preferably, the particle size is less than or equal to 180 μm.

10. The use of the compound nutrient as described in any one of claims 1 to 4 or the compound nutrient prepared by the preparation method described in any one of claims 5 to 9 as a lipid-lowering health product or medicine.

Images