A three-dimensional multi-nuclear spectral scanning positioning method and system based on region of interest optimization

By optimizing the magnetic resonance spectroscopy imaging positioning grid and combining high-resolution structural image data with T1-weighted images, precise positioning of multi-nucleus spectral scanning was achieved, solving the problems of inaccurate positioning and low efficiency in traditional methods, and improving the accuracy and operational efficiency of quantitative analysis.

CN120959715BActive Publication Date: 2026-01-23RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Application Number
CN202511467896.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-10-15
Publication Date
2026-01-23
Estimated Expiration
2045-10-15

AI Technical Summary

Technical Problem

Traditional magnetic resonance spectroscopy imaging localization methods rely on human experience, making it difficult to accurately locate multiple regions of interest. Furthermore, the lack of unified standards in existing technologies leads to inaccurate localization and low efficiency, especially affecting the accuracy of metabolite quantification in complex shapes.

Method used

By utilizing a multi-channel 1H head coil to acquire high-resolution structural image data, dividing the region of interest, optimizing the magnetic resonance spectroscopy imaging positioning grid, and combining the T1-weighted structural image acquired by the 1H/31P dual-tuned head coil as a reference space, multi-scale search and mapping are performed to achieve automatic positioning of three-dimensional multi-nucleus spectroscopy scanning.

Benefits of technology

It achieves precise alignment between the region of interest and the voxel of magnetic resonance spectroscopy imaging, improves the accuracy of localization and the accuracy of metabolite quantification, simplifies the post-processing process, expands the application scenarios of the technology, and supports localization optimization for multiple ROIs and custom lesions.

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Abstract

The present application relates to a kind of three-dimensional multi-nuclear spectrum scanning positioning method and system based on region of interest optimization, method includes: obtaining high-resolution structural image data, one or more regions of interest are divided, and the corresponding mask information is obtained;Optimization is carried out based on the type of region of interest, and the optimal positioning grid information of magnetic resonance spectroscopy imaging is obtained in high-resolution anatomical image space by multi-scale search;T1 weighted structural image is obtained as the reference space of magnetic resonance spectroscopy imaging scan, based on the mask information, the magnetic resonance spectroscopy imaging positioning grid information is mapped to reference space;Based on the magnetic resonance spectroscopy imaging positioning grid information registered to reference space, magnetic resonance spectroscopy imaging scan is carried out, and the closed loop of scan-analysis-optimization-scan is used to realize multi-nuclear spectrum scanning automatic optimization positioning.The present application realizes the accurate alignment of region of interest and magnetic resonance spectroscopy voxel, real-time three-dimensional magnetic resonance spectrum optimal positioning and simplifies post-processing.
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