Anti-hair-loss, plumping and hair-densifying essence

Abstract

The embodiment of the invention provides anti-hair-loss, plump and dense hair essence, and relates to the field of hair care essence. The essence is prepared from water, ethyl alcohol, butanediol, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, tetrahydromethylpyrimidine carboxylic acid, 1, 2-hexanediol, caprylyl glycol, a ginseng root extract, palmitoyl tetrapeptide-7, a cacumen biotae extract, 1, 2-hexanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol, 1, 3-pentanediol and the like. The preparation method comprises the following steps: adding 1, 3-propylene glycol, phenoxyethanol, p-hydroxyacetophenone, carbomer, triethanolamine, adenosine, hydrolyzed sodium hyaluronate, hydrolyzed collagen, hydrolyzed elastin, caramel color, a scutellaria baicalensis root extract, a ginger root extract, copper tripeptide-1, a chamomilla recutita flower extract, glycerin, polysorbate-20, lactic acid, ethylhexylglycerin, carnosine, acetyl hexapeptide-8, palmitoyl pentapeptide-4, 2, 4-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1, 2, 3-trimethyl-1 The composition is prepared from the following raw materials: palmitoyl tripeptide-1, rosemary leaf extract, acetyl hexapeptide-8, arginine / lysine polypeptide, acetyl tetrapeptide-2 and acetyl tetrapeptide-5.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of hair care essence, in particular to a hair loss prevention and hair growth promoting essence. BACKGROUND

[0002] Hair loss, as a common skin and hair health problem, has become an important factor affecting the quality of modern life. With the increase of life pressure, the aggravation of environmental pollution and the change of dietary structure, the incidence of hair loss is increasing year by year, especially androgenetic alopecia, postpartum hair loss and stress-induced alopecia, which often leads to gradual atrophy of hair follicles, disorder of hair growth cycle, and eventually causes hair thinning, oily or dry scalp and other symptoms. If not effectively intervened, it not only accelerates the process of hair loss, but also may be accompanied by scalp inflammation or psychological burden and other problems.

[0003] Existing hair loss prevention products are mainly divided into two categories: chemical synthesis and natural extraction. Chemical synthesis products usually stimulate hair follicle vasodilation or inhibit specific enzyme activity to achieve short-term growth promotion, but often accompanied by scalp irritation, allergic reactions or endocrine interference and other side effects, and rebound phenomenon is easy to occur after stopping use. Natural extraction products rely on single or a small number of plant ingredients, such as root or leaf extract of some Chinese herbal medicines, to improve scalp microcirculation or nourish hair follicles, but the extraction efficiency of active substances is low and the penetration is poor, resulting in unstable actual effect and difficulty in comprehensive regulation for different causes of hair loss. For example, some products can provide basic moisturizing and cleaning functions, but ignore the synergistic effect of multiple mechanisms, and cannot solve the problems of hair follicle regeneration, moisturizing and water retention, and antioxidant protection at the same time.

[0004] In addition, the existing formula also has challenges in stability. Many products use simple water-alcohol solvent system, which is easy to cause degradation or separation of active ingredients, especially in high temperature or humid environment, the pH value fluctuates greatly, affecting long-term storage and use experience. At the same time, the mildness for sensitive scalp is insufficient, the preservation and thickening mechanism is single, and it is difficult to balance efficacy and safety. Overall, these deficiencies make it difficult for existing hair loss prevention products to achieve the transition from treating symptoms to treating the root cause, and there is an urgent need for a composite essence of comprehensive plant extract and bioactive peptide, which can improve the bioavailability and long-term efficacy of ingredients by optimizing the solvent carrier, enhancing the penetration aid and fine pH control, so as to effectively inhibit hair loss, promote hair growth and improve scalp health. SUMMARY

[0005] According to the embodiments of the present application, a hair loss prevention and hair growth promoting essence is provided to solve the problems raised in the background art.

[0006] In a first aspect of the present application, a hair loss prevention and hair growth promoting essence is provided.

[0007] The anti-shedding and hair growth promoting essence comprises water, ethanol, butylene glycol, PPG-26-butyl polyether-26, PEG-40 hydrogenated castor oil, tetrahydro methyl pyrimidine carboxylic acid, 1,2-hexanediol, octoxyglycerol, ginseng root extract, palmitoyl tetrapeptide-7, cypress leaf extract, 1,3-propanediol, phenoxyethanol, p-hydroxyacetophenone, carbomer, triethanolamine, adenosine, sodium hyaluronate, hydrolyzed collagen, hydrolyzed elastin, caramel color, radix scrophulariae extract, ginger root extract, tripeptide-1 copper, mother chamomile flower extract, glycerol, polysorbate-20, lactic acid, ethylhexylglycerin, myo-inositol, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, rosemary leaf extract, acetyl hexapeptide-8, arginine / lysine polypeptide, acetyl tetrapeptide-2 and acetyl tetrapeptide-5.

[0008] Preferably, the water is the main solvent, the ethanol and butylene glycol are auxiliary solvents and humectants, the PPG-26-butyl polyether-26 and PEG-40 hydrogenated castor oil are hair conditioning agents, the tetrahydro methyl pyrimidine carboxylic acid, 1,2-hexanediol and octoxyglycerol are moisturizing and stabilizing agents, and the ginseng root extract, cypress leaf extract, radix scrophulariae extract, ginger root extract, mother chamomile flower extract and rosemary leaf extract are anti-shedding and hair conditioning agents.

[0009] Preferably, the content of the cypress leaf extract is 0.5%-3.0%, the content of the ginseng root extract is 0.1%-0.5%, the content of the radix scrophulariae extract is 0.005%-0.02%, the content of the ginger root extract is 0.005%-0.02%, the content of the mother chamomile flower extract is 0.001%-0.005%, and the content of the rosemary leaf extract is 0.0005%-0.002%.

[0010] Preferably, the content of the palmitoyl tetrapeptide-7 is 0.005%-0.03%, the content of the tripeptide-1 copper is 0.001%-0.01%, the content of the adenosine is 0.05%-0.15%, the content of the sodium hyaluronate is 0.02%-0.1%, the content of the hydrolyzed collagen is 0.02%-0.1%, and the content of the hydrolyzed elastin is 0.02%-0.1%.

[0011] Preferably, the content of the ethanol is 5%-10%, the content of the butylene glycol is 3%-7%, the content of the 1,2-hexanediol is 0.5%-2.0%, the content of the octoxyglycerol is 0.3%-1.0%, the content of the 1,3-propanediol is 0.2%-0.6%, the content of the p-hydroxyacetophenone is 0.3%-0.7%, and the content of the phenoxyethanol is 0.2%-0.5%.

[0012] Preferably, the content of the carbomer is 0.05%-0.2%, the content of the triethanolamine is 0.05%-0.2%, and the pH value is 5.0-7.0.

[0013] Preferably, the content of the glycerol is 0.001%-0.005%, the content of the polysorbate-20 is 0.0005%-0.002%, the content of the lactic acid is 0.0005%-0.002%, and the content of the ethylhexylglycerin is 0.0005%-0.002%.

[0014] Preferably, the content of the carnosine is 0.0005%-0.002%, the content of the acetyl hexapeptide-8 is 0.0005%-0.002%, the content of the palmitoyl pentapeptide-4 is 0.00005%-0.0002%, the content of the palmitoyl tripeptide-1 is 0.00005%-0.0002%, the content of the acetyl tetrapeptide-2 is 0.00005%-0.0002%, and the content of the acetyl tetrapeptide-5 is 0.00005%-0.0002%.

[0015] Preferably, the content of the arginine / lysine polypeptide is 0.00001%-0.0001%.

[0016] One or more technical solutions provided in the application have at least the following technical effects or advantages: The anti-hair loss and hair thickening essence provided by the application realizes multi-target regulation of hair follicles by the complex proportioning of plant extracts and polypeptide active ingredients, including inhibiting 5alpha-reductase activity, promoting scalp microcirculation, and enhancing hair follicle regeneration, and has a significant anti-hair loss and hair thickening effect. Compared with the prior art, the essence can effectively reduce the hair loss rate by more than 25%, increase the hair density by 15%, and improve the moisture content of the scalp by more than 17%, and is suitable for various types of male baldness and postpartum hair loss, avoiding the defects of easy rebound and irritation of chemical drugs.

[0017] The essence adopts a water-alcohol mixed solvent system, combines carbomer thickening and triethanolamine pH adjustment, ensures that the pH of the product is stable in the range of 5.5-6.5, the viscosity is moderate, and the product is easy to apply and absorb. Through accelerated aging test, the retention rate of active ingredients is more than 95%, there is no delamination or precipitation phenomenon, and the storage period is more than 24 months, which is better than the shortcoming of easy degradation of traditional plant extract products.

[0018] Furthermore, the synergistic effect of ingredients such as Platycladus orientalis leaf extract, ginseng root extract, and acetyl hexapeptide-8 in the formula of this invention not only enhances the antioxidant and moisturizing functions, but also reduces the incidence of scalp inflammation. It has excellent clinical tolerability, with no allergic or irritating reactions, and is especially suitable for people with sensitive skin, thus improving the overall health of the scalp.

[0019] It should be understood that the description in the Summary of the Invention is not intended to limit the key or essential features of the embodiments of the present invention, nor is it intended to restrict the scope of the invention. Other features of the invention will become readily apparent from the following description. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] Furthermore, the term "and / or" in this article is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. Additionally, the character " / " in this article generally indicates that the preceding and following related objects have an "or" relationship.

[0022] Example 1 This anti-hair loss and volumizing hair serum contains water as the main solvent, accounting for 78.5576%; The formula contains 8% ethanol as a co-solvent, 5% butylene glycol as a hair conditioning agent, and various plant extracts and active ingredients, such as 0.23% ginseng root extract, 1.8% arborvitae leaf extract, 0.01% scutellaria baicalensis root extract, 0.01% ginger root extract, 0.002% chamomile flower extract, and 0.001% rosemary leaf extract. It is also supplemented with 0.015% palmitoyl tetrapeptide-7, 0.005% copper tripeptide-1, 0.05% hydrolyzed sodium hyaluronate, 0.05% hydrolyzed collagen, 0.05% hydrolyzed elastin, 0.1% adenosine, and small amounts of preservatives such as phenoxyethanol (0.4%), p-hydroxyacetophenone (0.5%), 1.5% 1,2-hexanediol, 0.752% octyl glycol, and 0.45% 1,3-propanediol. The thickener carbomer accounts for 0.15%, the pH adjuster triethanolamine accounts for 0.15%, the colorant caramel color accounts for 0.05%, and trace amounts of peptides and protective agents such as acetyl hexapeptide-8 accounts for 0.001%, palmitoyl pentapeptide-4 accounts for 0.001%, palmitoyl tripeptide-1 accounts for 0.001%, acetyl tetrapeptide-2 accounts for 0.0002%, acetyl tetrapeptide-5 accounts for 0.0002%, arginine lysine peptide accounts for 0.001%, carnosine accounts for 0.001%, glycerol accounts for 0.0022%, polysorbate-20 accounts for 0.001%, lactic acid accounts for 0.001%, ethylhexylglycerin accounts for 0.0012%, tetrahydromethylpyrimidine carboxylic acid accounts for 1%, PPG-26-butanol polyether-26 accounts for 3.24%, and PEG-40 hydrogenated castor oil accounts for 2.16%, with the total ingredients accounting for 100%.

[0023] The preparation process of this serum begins with the aqueous phase. Water is heated to 70-80°C, and carbomer, hydrolyzed sodium hyaluronate, hydrolyzed collagen, and hydrolyzed elastin are added sequentially, stirring until completely dissolved to form a homogeneous aqueous matrix. Next, the oil phase is prepared. Ethanol, butylene glycol, PPG-26-butanol polyether-26, and PEG-40 hydrogenated castor oil are heated to 50-60°C and dissolved. Tetrahydromethylpyrimidine carboxylic acid, 1,2-hexanediol, and octyl glycol are added, and stirring continues until homogeneous.

[0024] Slowly add the oil phase to the aqueous phase and mix with high-speed stirring. At the same time, add adenosine, palmitoyl tetrapeptide-7, tripeptide-1 copper, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-2, acetyl tetrapeptide-5, arginine lysine peptide and carnosine to ensure that these active ingredients are evenly dispersed. Stir for no less than 30 minutes to enhance the synergistic effect of the ingredients.

[0025] After cooling to 40-50℃, add ginseng root extract, arborvitae leaf extract, scutellaria root extract, ginger root extract, chamomile flower extract, and rosemary leaf extract in sequence, stir well, and add caramel coloring to give the product a suitable appearance.

[0026] The temperature was further lowered to 30-40℃, and phenoxyethanol, p-hydroxyacetophenone, 1,3-propanediol, polysorbate-20, lactic acid, and ethylhexylglycerin were added as preservatives and stabilizers. Finally, the pH was adjusted to 5.5-6.5 with triethanolamine, and the mixture was stirred for 10 minutes before testing for confirmation. After the entire process was completed, the mixture was allowed to cool naturally to room temperature, filtered to remove impurities, and a transparent, slightly yellow liquid with moderate viscosity was obtained for convenient daily use.

[0027] When using this serum, apply 1-2 ml evenly to the scalp daily and massage for 5-10 minutes to promote absorption. Clinical tests show that after 4 weeks of continuous use, it can significantly reduce hair loss rate by more than 25% and increase hair density by 15%. This is due to the synergistic anti-hair loss effects of arborvitae leaf extract and ginseng root extract, as well as the regeneration-promoting effect of peptide ingredients on hair follicles. It is suitable for people with all types of hair loss.

[0028] To optimize adaptability to different skin types, variant formulations can be developed, such as increasing butylene glycol to 6% to enhance moisturizing effects while correspondingly reducing water content. The preparation method is the same as the original formulation. This variant is particularly suitable for dry scalps, with a 20% increase in moisturizing performance after use, further enhancing the effect of volumizing and thickening hair.

[0029] Example 2 To enhance antioxidant properties, the p-hydroxyacetophenone content in this embodiment was adjusted to 0.7%, and the water content was correspondingly reduced to 78.3576%, while other components remained unchanged. This anti-hair loss and volumizing hair serum contains water as the main solvent (78.3576%), ethanol as an auxiliary solvent (8%), butylene glycol as a hair conditioning agent (5%), and various plant extracts and active ingredients, such as ginseng root extract (0.23%), arborvitae leaf extract (1.8%), scutellaria root extract (0.01%), ginger root extract (0.01%), chamomile extract (0.002%), rosemary leaf extract (0.001%), and is supplemented with palmitoyl tetrapeptide-7 (0.015%), tripeptide-1 copper (0.005%), hydrolyzed sodium hyaluronate (0.05%), hydrolyzed collagen (0.05%), hydrolyzed elastin (0.05%), adenosine (0.1%), and small amounts of preservatives such as phenoxyethanol (0.4%), p-hydroxyacetophenone (0.7%), 1,2-hexanediol (1.5%), and caprylyl glycol (0.752%). The composition includes 0.45% 3-propanediol, 0.15% carbomer (thickener), 0.15% triethanolamine (pH adjuster), 0.05% caramel color (colorant), and trace amounts of peptides and protective agents such as acetyl hexapeptide-8 (0.001%), palmitoyl pentapeptide-4 (0.001%), palmitoyl tripeptide-1 (0.001%), acetyl tetrapeptide-2 (0.0002%), acetyl tetrapeptide-5 (0.0002%), arginine-lysine peptides (0.001%), carnosine (0.001%), glycerol (0.0022%), polysorbate-20 (0.001%), lactic acid (0.001%), ethylhexylglycerin (0.0012%), tetrahydromethylpyrimidine carboxylic acid (1%), PPG-26-butanol polyether-26 (3.24%), and PEG-40 hydrogenated castor oil (2.16%), totaling 100% of the total composition.

[0030] The preparation process of this serum begins with the aqueous phase. Water is heated to 70-80°C, and carbomer, hydrolyzed sodium hyaluronate, hydrolyzed collagen, and hydrolyzed elastin are added sequentially, stirring until completely dissolved to form a homogeneous aqueous matrix. Next, the oil phase is prepared. Ethanol, butylene glycol, PPG-26-butanol polyether-26, and PEG-40 hydrogenated castor oil are heated to 50-60°C and dissolved. Tetrahydromethylpyrimidine carboxylic acid, 1,2-hexanediol, and octyl glycol are added, and stirring continues until homogeneous.

[0031] Slowly add the oil phase to the aqueous phase and mix with high-speed stirring. At the same time, add adenosine, palmitoyl tetrapeptide-7, tripeptide-1 copper, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-2, acetyl tetrapeptide-5, arginine lysine peptide and carnosine to ensure that these active ingredients are evenly dispersed. Stir for no less than 30 minutes to enhance the synergistic effect of the ingredients.

[0032] After cooling to 40-50℃, add ginseng root extract, arborvitae leaf extract, scutellaria root extract, ginger root extract, chamomile flower extract, and rosemary leaf extract in sequence, stir well, and add caramel coloring to give the product a suitable appearance.

[0033] The temperature was further lowered to 30-40℃, and phenoxyethanol, p-hydroxyacetophenone, 1,3-propanediol, polysorbate-20, lactic acid, and ethylhexylglycerin were added as preservatives and stabilizers. Finally, the pH was adjusted to 5.5-6.5 with triethanolamine, and the mixture was stirred for 10 minutes before testing for confirmation. After the entire process was completed, the mixture was allowed to cool naturally to room temperature, filtered to remove impurities, and a transparent, slightly yellow liquid with moderate viscosity was obtained for convenient daily use.

[0034] When using this serum, apply 1-2 ml evenly to the scalp daily and massage for 5-10 minutes to promote absorption. Clinical tests show that after 4 weeks of continuous use, it can significantly reduce hair loss rate by more than 25% and increase hair density by 15%. This is due to the synergistic anti-hair loss effects of arborvitae leaf extract and ginseng root extract, as well as the regeneration-promoting effect of peptide ingredients on hair follicles. It is suitable for people with all types of hair loss, and its antioxidant effect is improved by 10%, making it more suitable for scalp environments with high oxidative stress.

[0035] Example 3 To enhance the moisturizing function, the content of hydrolyzed sodium hyaluronate in this embodiment is increased to 0.08%, and the water content is correspondingly reduced to 78.5276%, while other components remain unchanged. This anti-hair loss and volumizing hair serum contains water as the main solvent (78.5276%), ethanol as an auxiliary solvent (8%), butylene glycol as a hair conditioning agent (5%), and various plant extracts and active ingredients, such as ginseng root extract (0.23%), arborvitae leaf extract (1.8%), scutellaria root extract (0.01%), ginger root extract (0.01%), chamomile extract (0.002%), rosemary leaf extract (0.001%), and is supplemented with palmitoyl tetrapeptide-7 (0.015%), tripeptide-1 copper (0.005%), hydrolyzed sodium hyaluronate (0.08%), hydrolyzed collagen (0.05%), hydrolyzed elastin (0.05%), adenosine (0.1%), and small amounts of preservatives such as phenoxyethanol (0.4%), p-hydroxyacetophenone (0.5%), 1,2-hexanediol (1.5%), and caprylyl glycol (0.752%). The composition includes 0.45% 3-propanediol, 0.15% carbomer (thickener), 0.15% triethanolamine (pH adjuster), 0.05% caramel color (colorant), and trace amounts of peptides and protective agents such as acetyl hexapeptide-8 (0.001%), palmitoyl pentapeptide-4 (0.001%), palmitoyl tripeptide-1 (0.001%), acetyl tetrapeptide-2 (0.0002%), acetyl tetrapeptide-5 (0.0002%), arginine-lysine peptides (0.001%), carnosine (0.001%), glycerol (0.0022%), polysorbate-20 (0.001%), lactic acid (0.001%), ethylhexylglycerin (0.0012%), tetrahydromethylpyrimidine carboxylic acid (1%), PPG-26-butanol polyether-26 (3.24%), and PEG-40 hydrogenated castor oil (2.16%), totaling 100% of the total composition.

[0036] The preparation process of this serum begins with the aqueous phase. Water is heated to 70-80°C, and carbomer, hydrolyzed sodium hyaluronate, hydrolyzed collagen, and hydrolyzed elastin are added sequentially, stirring until completely dissolved to form a homogeneous aqueous matrix. Next, the oil phase is prepared. Ethanol, butylene glycol, PPG-26-butanol polyether-26, and PEG-40 hydrogenated castor oil are heated to 50-60°C and dissolved. Tetrahydromethylpyrimidine carboxylic acid, 1,2-hexanediol, and octyl glycol are added, and stirring continues until homogeneous.

[0037] Slowly add the oil phase to the aqueous phase and mix with high-speed stirring. At the same time, add adenosine, palmitoyl tetrapeptide-7, tripeptide-1 copper, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-2, acetyl tetrapeptide-5, arginine lysine peptide and carnosine to ensure that these active ingredients are evenly dispersed. Stir for no less than 30 minutes to enhance the synergistic effect of the ingredients.

[0038] After cooling to 40-50℃, add ginseng root extract, arborvitae leaf extract, scutellaria root extract, ginger root extract, chamomile flower extract, and rosemary leaf extract in sequence, stir well, and add caramel coloring to give the product a suitable appearance.

[0039] The temperature was further lowered to 30-40℃, and phenoxyethanol, p-hydroxyacetophenone, 1,3-propanediol, polysorbate-20, lactic acid, and ethylhexylglycerin were added as preservatives and stabilizers. Finally, the pH was adjusted to 5.5-6.5 with triethanolamine, and the mixture was stirred for 10 minutes before testing for confirmation. After the entire process was completed, the mixture was allowed to cool naturally to room temperature, filtered to remove impurities, and a transparent, slightly yellow liquid with moderate viscosity was obtained for convenient daily use.

[0040] When using this serum, apply 1-2 ml evenly to the scalp daily and massage for 5-10 minutes to promote absorption. Clinical tests show that after 4 weeks of continuous use, it can significantly reduce hair loss rate by more than 25% and increase hair density by 15%. This is due to the synergistic anti-hair loss effects of arborvitae leaf extract and ginseng root extract, as well as the regeneration-promoting effect of peptide ingredients on hair follicles. It is suitable for people with all types of hair loss, and the moisturizing effect is improved by 15%, making it especially suitable for sensitive and dry scalps.

[0041] To confirm the consistency between the actual content of each active ingredient in the anti-hair loss and volumizing hair essence of this invention and the formula design, this test example uses high performance liquid chromatography (HPLC) to quantitatively analyze the formulations of Examples 1, 2, and 3. After dilution, the samples were injected into a C18 column and eluted using an acetonitrile-water gradient. The detection wavelengths were 254 nm (peptides) and 280 nm (plant extracts), respectively. The results showed that the actual content of Platycladus orientalis leaf extract in Example 1 was 1.80%, with a deviation of <0.5% from the design value; ginseng root extract was 0.23%, with a deviation of 0.3%; adenosine was 0.099%, with a deviation of 0.1%; the content of p-hydroxyacetophenone in Example 2 reached 0.70%, with a deviation of <1%; and the content of hydrolyzed sodium hyaluronate in Example 3 was 0.080%, with a deviation of 0.2%. The peak purity of all active ingredients was >98%, with no interference from impurity peaks, confirming that the plant extracts in the formula, such as Scutellaria baicalensis root extract (0.01%) and ginger root extract (0.01%), had high extraction efficiency and excellent overall content stability.

[0042] This test example evaluated the physicochemical stability of the formulations in Examples 1, 2, and 3 using a pH meter (accuracy 0.01) and a rotational viscometer (Brookfield model). Samples were stored at 25°C for 3 months under accelerated conditions at 40°C, with pH (target 5.5-6.5) and viscosity (target 200-500 cps) measured monthly. Results showed that in Example 1, the initial pH was 6.0, decreasing to 6.1 at 25°C (change +0.1) and 5.9 at 40°C (change -0.1) after 3 months; the initial viscosity was 350 cps, with a change of <3%. In Example 2, the pH remained stable at 5.9-6.2, with a viscosity fluctuation of 2.5%, indicating that enhanced antioxidant properties helped maintain system equilibrium. In Example 3, the pH ranged from 6.1 to 6.3, with a viscosity change of <4%, suggesting that the moisturizing components improved long-term stability. No stratification or precipitation was observed, confirming the effectiveness of triethanolamine in pH adjustment and demonstrating the stability of the carbomer thickener in ethanol and butanediol solvent systems.

[0043] To ensure the microbial safety and heavy metal purity of the product, this test example used the national standard GB 15979 method for microbial counting and atomic absorption spectrometry (AAS) to detect the content of lead, mercury, arsenic, and cadmium. Samples were diluted and plated on nutrient agar plates, incubated at 37°C for 48 hours, and colonies were counted. The detection limit for heavy metals was 0.01 ppm. Results showed that the total colony count in all examples was <10 CFU / mL, and molds and yeasts were not detected, meeting cosmetic hygiene standards. The phenoxyethanol and 1,2-hexanediol preservative system effectively inhibited contamination. Regarding heavy metals, in Example 1, lead <0.005 ppm, mercury <0.001 ppm, arsenic <0.002 ppm, and cadmium <0.001 ppm; Examples 2 and 3 were similar, all below the limit of 0.01 ppm, with no risk of extract residue. This test verified the high purity of the raw materials, the absence of contamination in the production process, and the suitability of the product for use on sensitive scalps.

[0044] The specific embodiments described above do not constitute a limitation on the scope of protection of this invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A hair loss prevention and volumizing hair thickening essence, characterized in that, include: Water, ethanol, butylene glycol, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, tetrahydromethylpyrimidine carboxylic acid, 1,2-hexanediol, caprylyl glycol, ginseng root extract, palmitoyl tetrapeptide-7, arborvitae leaf extract, 1,3-propanediol, phenoxyethanol, p-hydroxyacetophenone, carbomer, triethanolamine, adenosine, hydrolyzed sodium hyaluronate, hydrolyzed collagen, hydrolyzed elastin, caramel color, scutellaria baicalensis root extract, ginger root extract, tripeptide-1 copper, matricaria chamomile extract, glycerin, polysorbate-20, lactic acid, ethylhexylglycerin, carnosine, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, rosemary leaf extract, acetyl hexapeptide-8, arginine / lysine peptide, acetyl tetrapeptide-2 and acetyl tetrapeptide-5.

2. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, Water is the main solvent, ethanol and butylene glycol are auxiliary solvents and humectants, PPG-26-butanol polyether-26 and PEG-40 hydrogenated castor oil are hair conditioning agents, tetrahydromethylpyrimidine carboxylic acid, 1,2-hexanediol and caprylyl glycol are moisturizing and stabilizing agents, and ginseng root extract, arborvitae leaf extract, scutellaria root extract, ginger root extract, chamomile flower extract and rosemary leaf extract are anti-hair loss agents and hair conditioning agents.

3. The anti-hair loss and volumizing hair thickening essence according to claim 2, characterized in that, The content of the arborvitae leaf extract is 0.5%-3.0%, the content of the ginseng root extract is 0.1%-0.5%, the content of the scutellaria root extract is 0.005%-0.02%, the content of the ginger root extract is 0.005%-0.02%, the content of the chamomile extract is 0.001%-0.005%, and the content of the rosemary leaf extract is 0.0005%-0.002%.

4. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, The content of palmitoyl tetrapeptide-7 is 0.005%-0.03%, the content of tripeptide-1 copper is 0.001%-0.01%, the content of adenosine is 0.05%-0.15%, the content of hydrolyzed sodium hyaluronate is 0.02%-0.1%, the content of hydrolyzed collagen is 0.02%-0.1%, and the content of hydrolyzed elastin is 0.02%-0.1%.

5. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, The ethanol content is 5%-10%, the butanediol content is 3%-7%, the 1,2-hexanediol content is 0.5%-2.0%, the octyl glycol content is 0.3%-1.0%, the 1,3-propanediol content is 0.2%-0.6%, the p-hydroxyacetophenone content is 0.3%-0.7%, and the phenoxyethanol content is 0.2%-0.5%.

6. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, The content of carbomer is 0.05%-0.2%, the content of triethanolamine is 0.05%-0.2%, and the pH value is 5.0-7.

0.

7. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, It also includes glycerin, polysorbate-20, lactic acid, and ethylhexylglycerin, wherein the content of glycerin is 0.001%-0.005%, the content of polysorbate-20 is 0.0005%-0.002%, the content of lactic acid is 0.0005%-0.002%, and the content of ethylhexylglycerin is 0.0005%-0.002%.

8. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, It also includes carnosine, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, acetyl tetrapeptide-2, and acetyl tetrapeptide-5, wherein the content of carnosine is 0.0005%-0.002%, the content of acetyl hexapeptide-8 is 0.0005%-0.002%, the content of palmitoyl pentapeptide-4 is 0.00005%-0.0002%, the content of palmitoyl tripeptide-1 is 0.00005%-0.0002%, the content of acetyl tetrapeptide-2 is 0.00005%-0.0002%, and the content of acetyl tetrapeptide-5 is 0.00005%-0.0002%.

9. The anti-hair loss and volumizing hair thickening essence according to claim 1, characterized in that, It also includes arginine / lysine peptides, with a content of 0.00001%-0.0001%.