PRP composite gel, and injection system and injection method thereof

By using PRP composite gel and electromagnetic synergistic injection system, the problems of injection blockage, growth factor diffusion and platelet activity loss in PRP therapy have been solved, achieving smooth fine needle injection and targeted sustained release of growth factors, significantly improving tissue repair efficiency.

CN120983346APending Publication Date: 2025-11-21ZHONGSHAN TORCH DEV ZONE PEOPLES HOSPITAL
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Patent Information

Application Number
CN202511148184.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-16
Publication Date
2025-11-21

AI Technical Summary

Technical Problem

Current PRP therapy suffers from problems such as injection blockage, uncontrolled diffusion of growth factors, and loss of platelet activity, resulting in significant tissue trauma and poor treatment outcomes.

Method used

The PRP composite gel, combined with a temperature-sensitive block copolymer matrix, functionalized magnetic nanoparticles, and an electromagnetic synergistic injection system, enables fine-needle injection, immediate gelation, and targeted sustained release. Through the synergistic effect of dual cross-linking and alternating magnetic field, the problems of blockage and growth factor diffusion during injection are solved, thus protecting platelet activity.

Benefits of technology

It achieves smooth fine-needle injection, targeted sustained release and efficient enrichment of growth factors, significantly improves tissue repair efficiency, reduces tissue trauma and platelet activity loss, and enhances treatment efficacy.

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Abstract

The invention relates to the technical field of biomedical engineering and regenerative medicine, and particularly discloses PRP composite gel. Comprising a component A and a component B, wherein the component A comprises a temperature-sensitive block copolymer matrix, a component B and a component C, the temperature-sensitive block copolymer matrix is prepared from Pluronic F-127 (the mass fraction is 20-25%) and methacrylic anhydride gelatin (GelMA (the mass fraction is 5-8%), and the methylacryloylation degree of the GelMA is 60-70%; the functionalized magnetic nanoparticles are characterized in that RGD peptides (the grafting rate is greater than or equal to 0.5 mu g / mg) are grafted on the surfaces of superparamagnetic Fe3O4 coated SiO2 nanoparticles (the particle size is 50 + / -5nm, and the thickness of a SiO2 coating layer is 8-10nm), and the mass fraction is 0.05-0.1%; the invention further provides an injection system and an injection method. According to the invention, the temperature-sensitive gel, the magnetic targeting PRP and the electromagnetic synergistic injection system are organically combined, so that the synergistic unification of three seemingly contradictory technical requirements of'fine needle injection '(27G), 'instant gelation' (completed within 3 seconds) and'directional slow release 'is successfully realized, and a major breakthrough is made technically.
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