Antibacterial, anti-inflammatory, itching-relieving and repairing eczema cream and preparation method thereof

Abstract

The invention discloses antibacterial, anti-inflammatory, itching-relieving and repairing eczema cream and a preparation method thereof, and relates to the field of medical cosmetics, the preparation method comprises the following steps: S1, placing cetostearyl alcohol, glyceryl stearate and ethylparaben in a container, heating and melting in a constant-temperature water bath of 75-85 DEG C, and stirring for 10-15 minutes while keeping the temperature to obtain a uniform and transparent oil phase; s2, putting deionized water, glycerol, Tween 80 and allantoin into another container, heating in a constant-temperature water bath at 75-85 DEG C, stirring until complete dissolution to obtain a uniform water phase, and keeping the temperature for 10-15 minutes; according to the eczema cream capable of resisting bacteria, diminishing inflammation, relieving itching and repairing and the preparation method of the eczema cream, the components of the cream are scientifically selected and compounded, especially plant extracts and synthetic functional components are synergistically combined, so that the cream which not only has remarkable antibacterial and anti-inflammatory curative effects, but also has excellent refreshing feeling and comfort level is provided; the use compliance of a patient is greatly improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the medical cosmetic technology, specifically relates to an anti-bacterial anti-inflammatory and itching-relieving and repairing eczema cream and a preparation method thereof. BACKGROUND

[0002] Eczema is a chronic inflammatory skin disease caused by multiple internal and external factors. Its core feature is the appearance of multiple forms of skin lesions such as erythema, papules, and blisters, accompanied by severe itching. This disease has a clear exudation tendency, and the skin rash has various forms, including erythema, papules, blisters, erosion, exudation, scales, scab, etc., and often symmetrically distributed on both sides of the body, such as hands, feet, ears, face, and flexor sides of limbs. Eczema often has a prolonged course and is prone to recurrence, causing a lot of discomfort to patients.

[0003] The etiology of eczema is complex and diverse, involving genetic factors, environmental factors, immune system abnormalities, and skin barrier dysfunction. Genetic factors play an important role in the pathogenesis of eczema, and people with a family history of allergies are more likely to develop the disease. Internal factors such as chronic digestive system diseases, mental stress, insomnia, excessive fatigue, and emotional changes can also induce eczema. External factors include contact with irritating substances such as cosmetics, soap, synthetic fibers, animal fur, and plant pollen. In addition, immune dysfunction, humid and stuffy environment, or climate change can also be a cause of eczema.

[0004] Existing external medications for treating eczema are mainly based on glucocorticoids, which have a quick effect, but long-term use can lead to skin atrophy, telangiectasia, pigmentation, and hormone dependence, resulting in poor patient compliance. In addition, non-hormonal drugs such as calcineurin inhibitors (e.g., tacrolimus) are also used, but they are expensive and can cause discomfort such as burning. Therefore, it is of great clinical significance and market value to develop an eczema treatment external preparation that is efficient, safe, has few side effects, and can be used long-term. SUMMARY

[0005] The purpose of the present application is to provide an anti-bacterial anti-inflammatory and itching-relieving and repairing eczema cream and a preparation method thereof to solve the problems of poor patient compliance, high price, and possible discomfort such as burning in the prior art.

[0006] To achieve the above-mentioned purpose, the present application provides the following technical solution: a preparation method of an anti-bacterial anti-inflammatory and itching-relieving and repairing eczema cream, comprising the following steps:

[0007] S1, placing cetyl stearyl alcohol, glyceryl stearate, and nipagin ethyl ester in a container, heating and melting in a constant temperature water bath at 75-85℃, and stirring for 10-15 minutes to obtain a uniform transparent oil phase;

[0008] S2, deionized water, glycerol, Tween 80, allantoin are placed in another container, heated in a constant temperature water bath at 75-85℃, stirred until completely dissolved, to obtain a uniform aqueous phase, and keep warm for 10-15 minutes;

[0009] S3, under high speed stirring at 1000-2000 rpm, the oil phase obtained in S1 is slowly added to the aqueous phase obtained in S2, and after adding, continue to stir emulsification at 75-85℃ for 10-15 minutes;

[0010] S4, stop heating, stir and cool at a rate of 1-3℃ / min, when the temperature drops to 40-45℃, add chlorhexidine acetate, Sophora flavescens extract, Cnidium monnieri extract, Scutellaria baicalensis extract, Fructus Kochiae extract, Cortex Phellodendri extract, Cortex Dictamni extract and Fructus Ignatii extract, stir for 20-30 minutes until evenly mixed;

[0011] S5, the cream obtained in S4 is transferred to a homogenizer, and is homogenized for 2-3 cycles under a pressure of 20-40 MPa, and then is degassed under a vacuum degree of -0.08 to -0.10 MPa;

[0012] S6, continue to stir and cool the degassed cream to 25-30℃, discharge, fill, to obtain the eczema cream.

[0013] Further, the pressure of the homogenization treatment in S5 is 25-35 MPa.

[0014] An antibacterial anti-inflammatory and itching-relieving eczema cream prepared by the above-mentioned preparation method, which is composed of the following components in mass percentage:

[0015] glycerol 15-20%, cetylstearyl alcohol 7-11%, glyceryl stearate 5-8%, Tween 80 0.3-0.6%, chlorhexidine acetate 0.05-0.15%, allantoin 0.3-0.5%, nipagin ethyl 0.1-0.3%, Sophora flavescens extract 0.6-1.0%, Cnidium monnieri extract 0.5-0.9%, Scutellaria baicalensis extract 0.4-0.8%, Fructus Kochiae extract 0.3-0.7%, Cortex Phellodendri extract 0.3-0.7%, Cortex Dictamni extract 0.2-0.6%, and Fructus Ignatii extract 0.2-0.5%, and the balance of deionized water;

[0016] wherein the sum of the mass percentages of the components is 100%, and the mass percentages of the seven plant extracts do not overlap.

[0017] Further, the following components in mass percentage are used:

[0018] Glycerin 17%, Cetostearyl alcohol 9%, Stearic acid glyceride 6%, Tween 80 0.4%, Chlorhexidine acetate 0.1%, Allantoin 0.4%, Nipagin ethyl 0.2%, Sophora flavescens extract 0.8%, Cnidium fruit extract 0.7%, Scutellaria extract 0.6%, Tribulus terrestris extract 0.5%, Cortex phellodendri extract 0.5%, Dictamnus dasycarpus extract 0.4%, and deionized water to 100%.

[0019] A use of the eczema cream described above in the preparation of a medicament for treating eczema, including acute eczema, subacute eczema and chronic eczema.

[0020] A use of the eczema cream described above in the preparation of a cosmetic or skin care product for relieving skin itching and repairing skin barrier.

[0021] Compared with the prior art, the eczema cream and the preparation method thereof provided by the application have the advantages that the ingredients of the cream are selected and compounded scientifically, especially the synergistic combination of plant extracts and synthetic active ingredients, so that the cream not only has significant antibacterial and anti-inflammatory effects, but also has excellent refreshing and comfortable feeling, greatly improving the use compliance of patients.

[0022] In addition, by simply improving the preparation method of the cream, the emulsification, homogenization and cooling process parameters are optimized, the rheological property of the cream is significantly improved, the cream is more easily applied and absorbed, the viscosity of the cream is effectively reduced, and the greasy and heavy feeling is avoided. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments described in the present application, and other drawings can also be obtained by those skilled in the art according to these drawings.

[0024] Figure 1 The cream preparation process schematic diagram provided by the embodiments of the present application;

[0025] Figure 2 The cream product real object diagram provided by the embodiments of the present application. DETAILED DESCRIPTION

[0026] In order to make those skilled in the art better understand the technical solutions of the present application, the present application will be further described in detail below with reference to the drawings.

[0027] Embodiment one:

[0028] Please refer to Figure 1The application discloses a preparation method of an antibacterial, anti-inflammatory, antipruritic and repairing eczema cream.

[0029] S1, cetyl stearyl alcohol, glyceryl stearate and nipagin ethyl ester are placed in a container, heated and melted in a constant temperature water bath at 75-85 DEG C, and stirred for 10-15 minutes, so that an uniform and transparent oil phase is obtained;

[0030] S2, deionized water, glycerol, Tween 80 and allantoin are placed in another container, heated and stirred in a constant temperature water bath at 75-85 DEG C until completely dissolved, so that an uniform water phase is obtained, and the temperature is kept for 10-15 minutes;

[0031] S3, the oil phase obtained in S1 is slowly added into the water phase obtained in S2 under high-speed stirring at 1000-2000 rpm, and after the addition is completed, the emulsion is continuously stirred at 75-85 DEG C for 10-15 minutes;

[0032] S4, the heating is stopped, the stirring is cooled at a rate of 1-3 DEG C / min, when the temperature is reduced to 40-45 DEG C, chlorhexidine acetate, sophora flavescens extract, cnidium monnieri extract, radix scrophulariae extract, cortex phellodendri extract, bauhinia championii extract and radix stellae extract are added, and stirred for 20-30 minutes until mixed uniformly;

[0033] S5, the cream obtained in S4 is transferred into a homogenizer, and homogenized for 2-3 times under a pressure of 20-40 MPa, and then the bubbles are removed under a vacuum degree of-0.08 to-0.10 MPa;

[0034] S6, the cream after the defoaming is continuously stirred and cooled to 25-30 DEG C, and then discharged, filled and sealed, so that the eczema cream is obtained.

[0035] The pressure of the homogenization treatment in S5 is 25-35 MPa.

[0036] The antibacterial, anti-inflammatory, antipruritic and repairing eczema cream is prepared from the following components in percentage by mass:

[0037] glycerol 17%, cetyl stearyl alcohol 9%, glyceryl stearate 6%, Tween 80 0.4%, chlorhexidine acetate 0.1%, allantoin 0.4%, nipagin ethyl ester 0.2%, sophora flavescens extract 0.8%, cnidium monnieri extract 0.7%, radix scrophulariae extract 0.6%, cortex phellodendri extract 0.5%, radix stellae extract 0.3%, bauhinia championii extract 0.4% and deionized water added to 100%.

[0038] The embodiment provides a wet eczema cream with optimal comprehensive performance, and the formula is selected according to mass percentage: glycerin 17.0%, cetyl stearyl alcohol 9.0%, glyceryl stearate 6.0%, Tween 80 0.4%, chlorhexidine acetate 0.1%, allantoin 0.4%, nipagin ethyl 0.2%, Sophora flavescens extract 0.8%, Cnidium monnieri extract 0.7%, Scutellaria baicalensis extract 0.6%, Tribulus terrestris extract 0.5%, Cortex Phellodendri extract 0.5%, Cortex Dictamni extract 0.4%, Broussonetia papyrifera extract 0.3%, and deionized water added to 100.0%, and the preparation method is as follows: the components are weighed according to the proportion;

[0039] Oil phase preparation: cetyl stearyl alcohol, glyceryl stearate and nipagin ethyl are placed in a beaker, melted in a constant temperature water bath at 80℃±2℃, and stirred for 12 minutes. Water phase preparation: deionized water, glycerin, Tween 80 and allantoin are placed in an emulsifying kettle, heated and stirred at 80℃±2℃ until dissolved, and kept for 15 minutes;

[0040] Emulsification: the oil phase is added to the water phase at 1500 rpm, and homogenized and emulsified at 80℃±2℃ for 15 minutes;

[0041] Cooling and dosing: stop heating, cool at a rate of about 2℃ / min, add chlorhexidine acetate and all plant extracts at 43℃, and stir for 25 minutes;

[0042] Homogenization and defoaming: homogenized twice at a pressure of 30MPa, and defoamed under a vacuum of-0.09MPa for 5 minutes;

[0043] Filling: cooled to 28℃, and discharged and filled.

[0044] The components of the cream prepared in the embodiment are shown in Table 1.

[0045] Example two:

[0046] The antibacterial anti-inflammatory and antipruritic wet eczema cream is prepared from the following components with mass percentage:

[0047] Glycerin 15-20%, cetyl stearyl alcohol 7-11%, glyceryl stearate 5-8%, Tween 80 0.3-0.6%, chlorhexidine acetate 0.05-0.15%, allantoin 0.3-0.5%, nipagin ethyl 0.1-0.3%, Sophora flavescens extract 0.6-1.0%, Cnidium monnieri extract 0.5-0.9%, Scutellaria baicalensis extract 0.4-0.8%, Tribulus terrestris extract 0.3-0.7%, Cortex Phellodendri extract 0.3-0.7%, Cortex Dictamni extract 0.2-0.6%, Broussonetia papyrifera extract 0.2-0.5%, and deionized water in the remainder;

[0048] The sum of the mass percentages of the components is 100%, and the mass percentages of the seven plant extracts do not overlap.

[0049] The present embodiment provides a cream with higher content of plant active ingredients, which is suitable for patients with more serious symptoms. The formula is selected by mass percentage: glycerin 16.0%, cetyl stearyl alcohol 8.0%, glyceryl stearate 5.5%, Tween 80 0.5%, chlorhexidine acetate 0.15%, allantoin 0.45%, nipagin ethyl 0.25%, Sophora flavescens extract 1.0%, Cnidium monnieri extract 0.9%, Scutellaria baicalensis extract 0.7%, Semen pruni extract 0.6%, Cortex phellodendri extract 0.6%, Cortex dictamni extract 0.5%, Broussonetia papyrifera extract 0.4%, and deionized water added to 100.0%.

[0050] The components of the cream prepared in the present embodiment are shown in Table 1.

[0051] The preparation method is the same as that of Example 1, and 0.2% panthenol is additionally added in the drug adding step.

[0052] Example Three:

[0053] The present embodiment provides a cream with lower concentration of active ingredients, which is suitable for subacute or sensitive skin. The formula is selected by mass percentage: glycerin 18.0%, cetyl stearyl alcohol 10.0%, glyceryl stearate 7.0%, Tween 80 0.35%, chlorhexidine acetate 0.08%, allantoin 0.35%, nipagin ethyl 0.15%, Sophora flavescens extract 0.65%, Cnidium monnieri extract 0.55%, Scutellaria baicalensis extract 0.45%, Semen pruni extract 0.35%, Cortex phellodendri extract 0.35%, Cortex dictamni extract 0.25%, Broussonetia papyrifera extract 0.25%, and deionized water added to 100.0%.

[0054] The components of the cream prepared in the present embodiment are shown in Table 1.

[0055] The preparation method is the same as that of Example 1.

[0056] Example Four:

[0057] The present embodiment provides a product using a natural preservative alternative.

[0058] The formula is selected by mass percentage: glycerin 17.5%, cetyl stearyl alcohol 9.0%, glyceryl stearate 6.0%, Tween 80 0.4%, chlorhexidine acetate 0.1%, allantoin 0.4%, octanediol 0.6%, Sophora flavescens extract 0.8%, Cnidium monnieri extract 0.7%, Scutellaria baicalensis extract 0.6%, Semen pruni extract 0.5%, Cortex phellodendri extract 0.5%, Cortex dictamni extract 0.4%, Broussonetia papyrifera extract 0.3%, and deionized water added to 100.0%. The preparation method is the same as that of Example 1, and octanediol is added together with the plant extracts.

[0059] The components of the cream prepared in the present embodiment are shown in Table 1.

[0060] Comparative Example:

[0061] The formulation is identical to Example 1, but does not contain any plant extract, which is replaced by an equal proportion of deionized water.

[0062] The components of the cream prepared in this example are shown in Table 1.

[0063] The preparation method is the same as Example 1.

[0064] Table 1 Formulation Table (wt%)

[0065]

[0066]

[0067] Performance Test

[0068] The performance test results of the creams of each example were compared by a third-party testing agency, and the test results are shown in Table 2.

[0069] Table 2 Performance Test Results

[0070]

[0071] The products of Examples 1-4 and the comparative example were tested: stability tests showed that the products of each example were stable in high temperature (60°C), high humidity (RH 92.5%), strong light irradiation and long-term conditions;

[0072] In vitro antibacterial experiments showed that the diameters of the inhibition zones of Examples 1, 2 and 4 against Staphylococcus aureus were significantly larger than that of the comparative example (P<0.01);

[0073] Human efficacy evaluation (120 volunteers) showed that after 4 weeks of use, the EASI score reduction rates of Examples 1-4 were significantly higher than that of the comparative example group (P<0.01), among which Example 2 showed the most significant improvement, and Example 4 had the highest subjective comfort score.

[0074] The above only describes certain exemplary embodiments of the present application by way of illustration, and it is needless to say that those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present application. Therefore, the above figures and descriptions are illustrative in nature and should not be understood as limiting the scope of protection of the claims of the present application.

Claims

1. A method for preparing an anti-bacterial, anti-inflammatory, anti-itching, repairing eczema cream, characterized in that, Comprising the following steps: S1, cetyl stearyl alcohol, glyceryl stearate, ethylparaben is placed in a container, heated to melt in 75-85℃ constant temperature water bath, incubation stirring 10-15 minutes, get uniform transparent oil phase; S2, deionized water, glycerol, Tween 80, allantoin is placed in another container, heated in 75-85℃ constant temperature water bath, stirring until completely dissolved, get uniform water phase, incubation 10-15 minutes; S3, under the high speed stirring of 1000-2000 revolutions per minute, the oil phase obtained by S1 is slowly added to the water phase obtained by S2, after adding, continue to stir emulsification at 75-85℃ for 10-15 minutes; S4, stop heating, with the rate of 1-3℃ / min stirring cooling, when the temperature drops to 40-45℃, add chlorhexidine acetate, sophora flavescens extract, cnidium extract, radix scrophulariae extract, cortex phellodendri extract, barks extract and extract of broussonetia; stirring 20-30 minutes to mix evenly; S5, the paste obtained by S4 is transferred into a homogenizer, and is homogenized for 2-3 cycles under a pressure of 20-40 MPa, and then is degassed under a vacuum degree of-0.08 to-0.10 MPa; S6, continue to stir and cool the degassed paste to 25-30℃, discharge, fill, get the eczema cream.

2. The process for the preparation of an antiseptic anti-inflammatory anti-itching repair eczema cream as claimed in claim 1, wherein, The pressure of the homogenization treatment in S5 is 25-35 MPa.

3. The anti-bacterial, anti-inflammatory, anti-itching, repairing eczema cream prepared by the method of any one of claims 1 or 2, characterized in that, Composed of the following components by mass percentage: glycerol 15-20%, cetyl stearyl alcohol 7-11%, glyceryl stearate 5-8%, Tween 80 0.3-0.6%, chlorhexidine acetate 0.05-0.15%, allantoin 0.3-0.5%, ethylparaben 0.1-0.3%, sophora flavescens extract 0.6-1.0%, cnidium extract 0.5-0.9%, radix scrophulariae extract 0.4-0.8%, cortex phellodendri extract 0.3-0.7%, barks extract 0.3-0.7%, extract of broussonetia 0.2-0.6%, and the balance of deionized water; wherein the sum of the mass percentages of the components is 100%, and the mass percentages of the seven plant extracts do not overlap.

4. The antibacterial, anti-inflammatory, antipruritic, and repairing eczema cream according to claim 3, characterized in that, Made of the following components by mass percentage: glycerol 17%, cetyl stearyl alcohol 9%, glyceryl stearate 6%, Tween 80 0.4%, chlorhexidine acetate 0.1%, allantoin 0.4%, ethylparaben 0.2%, sophora flavescens extract 0.8%, cnidium extract 0.7%, radix scrophulariae extract 0.6%, cortex phellodendri extract 0.5%, barks extract 0.5%, extract of broussonetia 0.4%, and deionized water to 100%.

5. Use of the eczema cream of any one of claims 3 or 4 in the preparation of a medicament for treating eczema, including acute eczema, subacute eczema and chronic eczema.

6. Use of the eczema cream of any one of claims 3 or 4 in the preparation of a cosmetic or skin care product for relieving skin itching and repairing skin barrier.

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