Bionic self-crimping material and application of bionic self-crimping material in nerve field

By designing a biomimetic self-curling material, and utilizing the differences in cross-linking density and dynamic water migration, the nerve ends can be autonomously curled and stably adhered. This solves the problems of size adaptation and suturing complexity of traditional nerve repair materials, and improves nerve regeneration and limb function recovery.

CN120983698APending Publication Date: 2025-11-21YONGYE (TAIZHOU) BIOMATERIALS CO LTD
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Patent Information

Application Number
CN202511143215.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-15
Publication Date
2025-11-21

AI Technical Summary

Technical Problem

Traditional nerve repair materials are difficult to match with the dynamic deformation of nerve tissue, have size limitations, are prone to unstable adhesion and inflammatory reactions at the moist tissue interface, and the suturing operation is complicated, which affects the nerve regeneration effect.

Method used

A biomimetic self-curling material was designed. By photopolymerizing acrylic acid with N-hydroxysuccinimide, chitosan and glutaraldehyde to form a hydrogel, epigallocatechin gallate was introduced. The structure of mimosa leaf was simulated by the difference in crosslinking density and dynamic water migration, so as to achieve autonomous curling and stable adhesion of the material, avoiding the need for suture fixation.

Benefits of technology

The material can automatically curl into a tube within seconds to match nerve ends of different thicknesses, forming a stable adhesive layer, reducing the risk of inflammation, simplifying the operation, promoting nerve regeneration, reducing the probability of infection, improving the efficiency of nerve electrical signal transmission, and restoring limb function to near normal.

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Abstract

The invention discloses a bionic self-crimping material and application in the nerve field, and relates to the technical field of nano materials. The preparation method comprises the following steps: firstly, carrying out ultraviolet photopolymerization on acrylic acid and acrylic acid-N-hydroxysuccinimide, adding chitosan and glutaraldehyde to form hydrogel, and introducing epigallocatechin gallate into a chitosan-acrylic acid network. The material is rapidly and autonomously curled into a tube shape after being in contact with wet nerves, glutaraldehyde is directionally and orderly diffused by adopting a three-channel micro-fluidic chip, and the fineness is improved, so that the matching degree of nerve broken ends with different thicknesses is increased; the surface active groups of the material and the natural component chitosan cooperate to realize suture-free fixation; the plant phenol antioxidant removes free radicals at nerve injury parts; the degradation period is synchronous with natural healing of nerves, and secondary operation for taking out is not needed. The electroneurographic signals using the material are transmitted more smoothly, the target muscle atrophy degree is reduced, and the limb movement function is recovered to be close to the normal level.
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