Anti-saccharification composition, cosmetic as well as preparation method and application of anti-saccharification composition and cosmetic

Abstract

The invention provides an anti-saccharification composition, a cosmetic as well as a preparation method and application of the anti-saccharification composition. The anti-saccharification composition comprises a chamomilla recutita flower extract, a plantago major seed extract and pear juice fermentation product filtrate, the chamomilla recutita flower extract promotes epidermal cells to grow new cells, the plantago major seed extract can prevent the epidermal cells from saccharification reaction, and the pear juice fermentation product filtrate can effectively remove saccharified proteins; the three anti-saccharification extracts are combined together to exert different effects respectively, the anti-saccharification effect is highlighted in a three-in-one combination mode, the anti-saccharification effect can be embodied to the maximum extent, the better, better and more comprehensive effect can be exerted compared with single use, the anti-saccharification effect of epidermal cells is helped to the maximum extent, and the anti-saccharification effect of the epidermal cells is improved. Epidermal cells are full of vitality and vitality for a long time.

Description

Technical Field

[0001] This application belongs to the field of functional cosmetics technology, and in particular relates to an anti-glycation composition, cosmetic, preparation method and application thereof. Background Technology

[0002] With societal development and rising living standards, consumers are using more and more cosmetics, and anti-glycation cosmetics are receiving increasing attention in their daily skincare routines. Currently, the technological development of anti-glycation cosmetics is undergoing a transformation from single-ingredient screening to multi-dimensional mechanism analysis, and from in vitro validation to precise clinical evaluation. Therefore, anti-glycation cosmetics have significant application value. Summary of the Invention

[0003] This application provides an anti-glycation composition, a cosmetic, a method for preparing the same, and its application, to address the problems existing in related technologies. The technical solution is as follows:

[0004] In a first aspect, embodiments of this application provide an anti-glycation composition comprising the following components in parts by weight:

[0005] 1-30 parts of marigold extract; 1-20 parts of psyllium seed extract; 1-30 parts of pear juice fermentation product filtrate.

[0006] In one embodiment, the following components are included in parts by weight:

[0007] 5-15 parts of marigold extract; 3-10 parts of psyllium seed extract; 5-15 parts of pear juice fermentation product filtrate.

[0008] In one embodiment, the method for preparing chamomile extract includes the following steps:

[0009] Mix chamomile with the first extraction solvent at a material ratio of 1:(7-10); stir thoroughly, soak for 48-50 hours, stir thoroughly, filter, and collect the filtrate; the first extraction solvent is a mixture of 95% ethanol, 1,3-butanediol or glycerol at a weight ratio of 4:(4-6);

[0010] The filtrate was concentrated at 55-60℃ and -0.10--0.05MPa until it reached 40-60%. Concentration was then stopped, and 5-15% pure water was added and stirred until homogeneous. After standing, the solid and liquid phases were separated, and the liquid phase was the chamomile extract.

[0011] In one embodiment, the preparation method of psyllium seed extract includes the following steps:

[0012] Plantago seeds are mixed with the second extraction solvent at a material ratio of 1:(17-20); the mixture is steamed at 95℃ for 3-4 hours, then cooled, and then the solid and liquid are separated and the filtrate is collected; the second extraction solvent is a mixture of pure water, 1,3-butanediol or glycerol, and 95% alcohol at a weight ratio of 1:(6-8):(8-12);

[0013] The filtrate was concentrated by distillation at 70-75℃ and -0.10--0.05MPa until no more distillate dripped out; then 5-10% pure water was added, stirred evenly, and allowed to stand before solid-liquid separation. The liquid phase was the Plantago seed extract.

[0014] In one embodiment, the method for preparing pear juice fermentation product filtrate includes the following steps:

[0015] Mix pears and pure water in a ratio of 1:(2-4), and blend them in a high-speed blender to obtain pear juice.

[0016] Add the Lactobacillus culture medium to the pear juice at a weight ratio of 1:(25-35) and ferment at 35-38℃ for 36-60 hours. Adjust the pH of the fermentation broth to 6.5-7.0, and then separate the solid and liquid. The filtrate is the pear juice fermentation product filtrate.

[0017] In one embodiment, the solid-liquid separation process includes: filtering the fermentation broth with 400-mesh gauze, centrifuging the filtrate at 8000-8500 rpm for 5-10 minutes; filtering the supernatant after centrifugation using a 5μm PP cotton core filter, and the filtrate is the pear juice fermentation product filtrate.

[0018] Secondly, embodiments of this application provide the application of the anti-glycation composition in the preparation of anti-glycation cosmetics.

[0019] Thirdly, embodiments of this application provide a cosmetic product comprising the aforementioned anti-glycation composition; the anti-glycation composition constitutes 5-50% by weight in the cosmetic product.

[0020] In one embodiment, the following components are also included in weight percentage:

[0021] The composition includes 5-15% polyol, 1-3% betaine, 0.1-0.5% carbomer, 0.5-1.5% auxiliaries, and 40-80% water.

[0022] In one embodiment, the polyol is one or a combination of two or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol, or sorbitol.

[0023] The additives are fragrances and preservatives.

[0024] The advantages or beneficial effects of the above technical solutions include at least the following:

[0025] The anti-glycation composition of this application comprises chamomile extract, plantain seed extract, and pear juice fermentation filtrate. Chamomile extract promotes the growth of new epidermal cells, plantain seed extract inhibits glycation reactions in epidermal cells, and pear juice fermentation filtrate effectively removes glycated proteins. Therefore, the three ingredients work synergistically, highlighting anti-glycation through a three-pronged approach. This maximizes the anti-glycation effect, providing greater, better, and more comprehensive benefits, and helping epidermal cells resist glycation to the greatest extent possible, keeping epidermal cells full of vitality and vigor for a long time.

[0026] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of this application will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description

[0027] In the accompanying drawings, unless otherwise specified, the same reference numerals throughout the various drawings denote the same or similar parts or elements. These drawings are not necessarily drawn to scale. It should be understood that these drawings depict only some embodiments disclosed in this application and should not be construed as limiting the scope of this application.

[0028] Figure 1 Images showing the skin darkening and glycation caused by applying 1% dihydroxyacetone (DHA).

[0029] Figure 2 The image shows the recovery effect of glycated and darkened skin after treatment using Example 3 and Example 5. Detailed Implementation

[0030] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of this application. Therefore, the drawings and description are considered to be exemplary in nature and not restrictive.

[0031] This application studies the application of anti-glycation compositions in cosmetics, promotes the development of anti-glycation efficacy claims, further enhances the scientific validity and credibility of anti-glycation, and injects long-term growth momentum into the market.

[0032] This application provides an anti-glycation composition comprising the following components in parts by weight:

[0033] 1-30 parts of marigold extract; 1-20 parts of psyllium seed extract; 1-30 parts of pear juice fermentation product filtrate.

[0034] As one embodiment, the anti-glycation composition comprises the following components in parts by weight:

[0035] 5-15 parts of marigold extract; 3-10 parts of psyllium seed extract; 5-15 parts of pear juice fermentation product filtrate.

[0036] This product combines three anti-glycation extracts: chamomile extract, psyllium seed extract, and pear juice fermentation filtrate. Each extract exerts its unique effect, working synergistically to maximize anti-glycation efficacy when added to cosmetics. Chamomile extract promotes the growth of new epidermal cells, psyllium seed extract inhibits glycation in epidermal cells, and pear juice fermentation filtrate effectively removes glycated proteins. Therefore, the combined use of these three extracts provides complementary benefits, maximizing anti-glycation efficacy. Compared to using them individually, this combination offers greater, better, and more comprehensive benefits, effectively helping epidermal cells resist glycation and maintaining their long-term vitality.

[0037] As one implementation method, the preparation method of chamomile extract includes the following steps:

[0038] Mix chamomile with the first extraction solvent at a material ratio of 1:(7-10); stir thoroughly, soak for 48-50 hours, stir thoroughly, filter, and collect the filtrate; the first extraction solvent is a mixture of 95% ethanol, 1,3-butanediol or glycerol at a weight ratio of 4:(4-6);

[0039] The filtrate was concentrated at 55-60℃ and -0.10--0.05MPa until it reached 40-60%. Concentration was then stopped, and 5-15% pure water was added and stirred until homogeneous. After standing, the solid and liquid phases were separated, and the liquid phase was the chamomile extract.

[0040] The chamomile extract obtained using this method is rich in apigenin, quercetin, polysaccharides, and various amino acids, which can effectively promote the metabolism of epidermal cells, continuously provide new cells to epidermal cells, effectively replenish cells that die due to glycation, and make epidermal cells more vibrant.

[0041] In this embodiment, the solid-liquid separation is achieved by filtration using 800-mesh gauze.

[0042] As one implementation method, the preparation method of Plantago seed extract includes the following steps:

[0043] Plantago seeds are mixed with the second extraction solvent at a material ratio of 1:(17-20); the mixture is steamed at 95℃ for 3-4 hours, then cooled, and then the solid and liquid are separated and the filtrate is collected; the second extraction solvent is a mixture of pure water, 1,3-butanediol or glycerol, and 95% alcohol at a weight ratio of 1:(6-8):(8-12);

[0044] The filtrate was concentrated by distillation at 70-75℃ and -0.10--0.05MPa until no more distillate dripped out; then 5-10% pure water was added, stirred evenly, and allowed to stand before solid-liquid separation. The liquid phase was the Plantago seed extract.

[0045] The plant seed extract obtained using this method is rich in various flavonoids, which can effectively inhibit glycation of epidermal cells and prevent skin from turning brown due to glycation.

[0046] In this embodiment, the solid-liquid separation is achieved by filtration using 800-mesh gauze.

[0047] As one implementation method, the preparation method of pear juice fermentation product filtrate includes the following steps:

[0048] Mix pears and pure water in a ratio of 1:(2-4), and blend them in a high-speed blender to obtain pear juice.

[0049] Add the Lactobacillus culture medium to the pear juice at a weight ratio of 1:(25-35) and ferment at 35-38℃ for 36-60 hours. Adjust the pH of the fermentation broth to 6.5-7.0, and then separate the solid and liquid. The filtrate is the pear juice fermentation product filtrate.

[0050] As one implementation method, the solid-liquid separation process includes: filtering the fermentation broth with 400-mesh gauze, centrifuging the filtrate at 8000-8500 rpm for 5-10 minutes; filtering the supernatant after centrifugation with a 5μm PP cotton core, and the filtrate is the pear juice fermentation product filtrate.

[0051] The filtrate of pear juice fermented using this method contains various vitamins and amino acids, which can promote the metabolism of epidermal cells, quickly remove glycosylated proteins from the cells, and provide epidermal cells with a better living environment.

[0052] In this embodiment, sodium carbonate is used to adjust the pH of the fermentation broth to 6.5-7.0.

[0053] This application also provides the use of the anti-glycation composition in the preparation of anti-glycation cosmetics.

[0054] This application provides a cosmetic product comprising the aforementioned anti-glycation composition; the anti-glycation composition constitutes 5-50% by weight in the cosmetic product. Applied topically, the anti-glycation composition interacts with skin cells, helping epidermal cells resist glycation and maintaining their vitality and vigor for an extended period.

[0055] As one embodiment, it also includes the following components by weight percentage:

[0056] The composition includes 5-15% polyol, 1-3% betaine, 0.1-0.5% carbomer, 0.5-1.5% auxiliaries, and 40-80% water.

[0057] In one embodiment, the polyol is one or a combination of two or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol, or sorbitol.

[0058] The additives are fragrances and preservatives; the fragrances are selected from those commonly used in the art. The preservatives are preferably one or a combination of phenoxyethanol, p-hydroxyacetophenone, octyl glycol, pentylene glycol, or hexanediol.

[0059] The following provides a further explanation using specific implementation methods.

[0060] Example 1

[0061] Preparation of chamomile extract:

[0062] 1) Clean the chamomile flowers and then dry them at a low temperature not exceeding ℃, and set aside for later use;

[0063] 2) Mix chamomile with 95% alcohol and 1,3-butanediol in a weight ratio of 1:4:5, stir thoroughly, soak for 48-50 hours, stir thoroughly, and then filter through 400-mesh gauze to collect the filtrate.

[0064] 3) Transfer the filtrate to a vacuum pot for distillation. Set the temperature to 55-60℃ and the pressure to -0.10--0.05MPa. When about 50% of the filtrate remains in the pot, stop heating, release the filtrate, add 10% pure water, stir well, let stand, and then filter through 800-mesh gauze. The filtrate is the chamomile extract.

[0065] Preparation of Plantago seed extract:

[0066] 1) Clean the psyllium seeds thoroughly, then dry them and set aside for later use;

[0067] 2) Mix psyllium seeds with pure water, 1,3-butanediol and 95% alcohol in a weight ratio of 1:1:8:10, place in a heated reflux pot, set the temperature to 95℃, heat and reflux for 3-4 hours, cool down after completion, filter with 200 mesh gauze and take the filtrate.

[0068] 3) Transfer the filtrate to a vacuum pot for distillation. Set the temperature to 70-75℃ and the pressure to -0.10--0.05MPa. Stop heating when no more distillate drips out during distillation. Discharge the liquid from the pot, add 10% pure water, stir well, let stand, and then filter through 800-mesh gauze. The filtrate is the Plantago seed extract.

[0069] Preparation of pear juice fermentation product filtrate:

[0070] 1) Wash the pears thoroughly, let them air dry, and set aside.

[0071] 2) Mix pears and pure water in a 1:3 weight ratio, place in a blender, and blend on normal speed. Then pour the mixture into a fermentation tank and set aside.

[0072] 3) Dissolve the commercially available lyophilized lactobacillus powder in MRS medium and then incubate it in a 37°C incubator. After 24 hours, take out the lactobacillus culture and add it to a fermenter containing pear juice at a weight ratio of 1:30. Set the fermenter to a constant temperature of 37°C and ferment for 48 hours. Then take the fermentation liquid and adjust the pH to 6.5-7.0 with sodium carbonate. Filter it through 400-mesh gauze and take the filtrate.

[0073] 4) After centrifuging the filtrate at 8000-8500 rpm, filter it through a 5μm PP cotton core and collect the filtrate to obtain the pear juice fermentation product filtrate.

[0074] Example 2

[0075] The difference between Example 2 and Example 1 is that 1,3-butanediol in the extraction solvent is replaced with glycerol, while the other conditions are the same as in Example 1.

[0076] Example 3

[0077] A serum containing an anti-glycation composition, comprising the following components in weight percentages:

[0078] Example 1 contains 15.0% chamomile extract; Example 1 contains 10.0% plantain seed extract; Example 1 contains 15.0% pear juice fermentation product filtrate; 10.0% polyol; 2.0% betaine; 0.3% carbomer; 1.0% auxiliaries; and 46.7% water. The betaine used is a product of DuPont. The polyol is selected from one or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol, and sorbitol. The auxiliaries consist of fragrance and preservatives.

[0079] The preparation method includes the following steps:

[0080] Disperse the polyol, betaine, and carbomer together completely, add them to the emulsification pot, then add purified water, start stirring and heating, heat to 82±2℃, keep warm for 5 minutes, and stir until dissolved evenly;

[0081] When the temperature drops to around 50°C, add chamomile extract, plantain seed extract, pear juice fermentation filtrate, and auxiliary ingredients, then stir well and mix thoroughly to obtain an essence containing an anti-glycation composition.

[0082] Example 4

[0083] The difference between Example 4 and Example 3 is that the content of the components in the serum containing the anti-glycation composition is different:

[0084] Example 1 contains 5.0% chamomile extract; Example 1 contains 3.0% plantain seed extract; Example 1 contains 5.0% pear juice fermentation product filtrate; 10.0% polyol; 2.0% betaine; 0.3% carbomer; 1.0% auxiliaries; and 73.7% water. The betaine is a product of DuPont, USA. The polyol is selected from one or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol, and sorbitol. The auxiliaries consist of fragrance and preservatives. The preparation method is the same as in Example 3.

[0085] Example 5

[0086] The difference between Example 5 and Example 3 is that the chamomile extract, plantain seed extract, and pear juice fermentation product filtrate in Example 5 were prepared using those from Example 2.

[0087] The content of other components and the preparation method are the same as in Example 3.

[0088] Comparative Example 1

[0089] A method for preparing a cosmetic essence, comprising the following components by weight percentage: water 83.7%; carnosine 3.0%; polyol 10.0%; betaine 2.0%; carbomer 0.3%; and auxiliary agent 1.0%; wherein the carnosine is a product purchased from Shenzhen Ruidelin Biotechnology Co., Ltd., and its content is above 99.0%; the preparation method of the essence is the same as in Example 3.

[0090] Comparative Example 2

[0091] The difference between Comparative Example 2 and Example 3 is that the plantago seed extract of Example 1 was replaced with water, while the content of other components and the preparation method were the same as those of Example 3.

[0092] Comparative Example 3

[0093] The difference between Comparative Example 3 and Example 3 is that the pear juice fermentation product filtrate of Example 1 was replaced with water, while the content of other components and the preparation method were the same as those of Example 3.

[0094] Cosmetic testing:

[0095] 1. Security Testing

[0096] Twenty-four volunteers with good skin were selected for testing. They were divided into six groups of four. Each group tested the anti-glycation serum samples from Examples 3-5 and Comparative Examples 1-3, respectively. Each participant used a patch control experiment on the inner side of both arms. A 36-well patch of the product of this invention was applied to the inner side of the left arm, while a 36-well patch with a blank base was applied to the inner side of the right arm, twice daily. Skin reactions were recorded after 24 hours, 48 ​​hours, and 72 hours. The data are shown in Table 1.

[0097] Table 1

[0098]

[0099]

[0100] As can be seen from the results in Table 1, no skin redness, itching, or erythema or other allergic reactions were observed 24h, 48h, and 72h after applying the product of the present invention. This indicates that the anti-glycation essence in the embodiments and comparative examples of the present invention is safe and no adverse reactions occurred.

[0101] 2. Application effect test

[0102] A 20-year-old female volunteer was selected, and 1% dihydroxyacetone DHA stock solution was applied to the inside of the backs of both her hands twice a day for one week. Photos were then taken to document the process. (The photos are shown below.) Figure 1 As shown; then continue to apply the essences of Example 3 and Example 5 to the inner skin of both hands respectively, applying the sample of Example 3 to the skin of the left hand and the sample of Example 5 to the skin of the right hand, twice a day for one week. During this period, the volunteer is required not to apply other products. After completion, continue to take photos, as shown in the photos. Figure 2 As shown;

[0103] from Figure 2As can be seen, the pigmentation on the inner skin of the hand treated with the sample of Example 3 disappeared faster than that on the inner skin of the hand treated with the sample of Example 5. This indicates that the extract obtained using 1,3-butanediol is significantly better than that obtained using other polyols (glycerol), and the use of 1,3-butanediol as the extraction solvent in this application demonstrates its superior performance.

[0104] 3. Human anti-glycation test

[0105] (1) Six healthy volunteers aged 25-40 were selected and numbered 1, 2, 3, 4, 5 and 6.

[0106] (2) Volunteers No. 1, No. 2, No. 3, No. 4, No. 5, and No. 6 were asked to apply 1% dihydroxyacetone DHA stock solution to the left side of their face twice a day for one week. Then, the left side of their face was scanned using the Visia 7th generation skin analyzer, and the area of ​​skin darkening due to glycation was recorded. The area data is shown in Table 2.

[0107] (3) Volunteers No. 1, No. 2, No. 3, No. 4, No. 5, and No. 6 were asked to apply the serums of Examples 3-5 and Comparative Examples 1-3 evenly to the glycated skin on their faces twice a day for one week. During this period, volunteers were required to pay attention to sun protection and not to use other products. After the time was up, the Visia skin tester was used to take a picture and scan the skin to record the improvement of their facial skin. The data is recorded as shown in Table 2.

[0108] Table 2

[0109]

[0110] The data in Table 2 show that Example 3 of this application has the best effect on anti-glycation of the skin. Example 3 is better than Example 5, and Example 5 is better than Example 4. This indicates that the selection of extraction solvent and the ratio of the composition in Example 3 are the most suitable, and the effect is the most obvious. It is even better than the anti-glycation effect of adding carnosine in Comparative Example 1. Furthermore, the results of Comparative Examples 2 and 3 show that the anti-glycation composition developed in this application will greatly reduce the anti-glycation effect if any one of them is missing. Therefore, the anti-glycation composition developed in this application has good efficacy and innovation.

[0111] 4. In vitro anti-glycation model test

[0112] (1) Weigh a certain amount of bovine serum albumin and glucose and mix them in a beaker. Then divide the mixture into 7 small beakers of equal volume. After dividing, add the contents of Examples 3-5 and Comparative Examples 1-3 of this patent respectively, and leave one blank sample. Mark each sample accordingly.

[0113] (2) After sealing the sample from step 1 in a beaker with plastic wrap, place it at 65°C.

[0114] (3) Then, the above sample solutions were placed in spectrophotometer bottles and placed in a fluorescence spectrophotometer. The excitation wavelength was set to 370 nm. The absorption concentration of the AGEs, the final product of the saccharification reaction, was detected. The saccharification product inhibition rate of the sample was calculated according to the formula: saccharification product inhibition rate % = 1 - saccharification product of the sample experimental group / saccharification product of the blank group * 100%. The results are shown in Table 3.

[0115] Table 3

[0116]

[0117]

[0118] As shown in Table 3, the serums of Examples 3 and 5 achieved glycation product inhibition rates of over 91.3%, with Example 3 even reaching 98.6%. The serum of Example 4 also achieved a glycation product inhibition rate of 88.7%. This is better than the serum of Comparative Example 1, which used carnosine as the active ingredient. In contrast, Comparative Examples 2 and 3 showed less than 20% anti-glycation effect, indicating poor anti-glycation efficacy.

[0119] Human and in vitro anti-glycation evaluation experiments showed that Example 3 had the best and most significant anti-glycation effect. Example 4, with half the content of the anti-glycation composition, still showed an advantage over carnosine in anti-glycation. Therefore, the preparation method and application of the anti-glycation composition of this invention have excellent anti-glycation effects, effectively preventing skin protein glycation, enhancing skin transparency, maintaining vitality and elasticity, and making the skin look younger. The effects of Comparative Examples 2-3 demonstrate that the combination of the three components in the anti-glycation composition of this invention can achieve a greater and better anti-glycation effect; the absence of any one component significantly reduces the anti-glycation effect. Therefore, this invention's anti-glycation composition is innovative and effective, providing a very good functional application for cosmetics.

[0120] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of those different embodiments or examples.

[0121] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "a plurality of" means two or more, unless otherwise explicitly specified.

[0122] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in this application, and these should all be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. An anti-glycation composition, characterized in that, Includes the following components by weight: 1-30 parts of marigold extract; 1-20 parts of psyllium seed extract; 1-30 parts of pear juice fermentation product filtrate.

2. The anti-glycation composition according to claim 1, characterized in that, Includes the following components by weight: 5-15 parts of marigold extract; 3-10 parts of psyllium seed extract; 5-15 parts of pear juice fermentation filtrate.

3. An anti-glycation composition according to claim 1 or 2, characterized in that, The preparation method of chamomile extract includes the following steps: Mix chamomile with the first extraction solvent at a material ratio of 1:(7-10); stir thoroughly, soak for 48-50 hours, stir thoroughly, filter, and collect the filtrate; the first extraction solvent is a mixture of 95% ethanol, 1,3-butanediol or glycerol at a weight ratio of 4:(4-6); The filtrate was concentrated at 55-60℃ and -0.10--0.05MPa until it reached 40-60%. Concentration was then stopped, and 5-15% pure water was added and stirred until homogeneous. After standing, the solid and liquid phases were separated, and the liquid phase was the chamomile extract.

4. An anti-glycation composition according to claim 1 or 2, characterized in that, The preparation method of Plantago seed extract includes the following steps: Plantago seeds are mixed with the second extraction solvent at a material ratio of 1:(17-20); the mixture is steamed at 95℃ for 3-4 hours, then cooled, and then the solid and liquid are separated and the filtrate is collected; the second extraction solvent is a mixture of pure water, 1,3-butanediol or glycerol, and 95% alcohol at a weight ratio of 1:(6-8):(8-12); The filtrate was concentrated by distillation at 70-75℃ and -0.10--0.05MPa until no more distillate dripped out; 5-10% pure water was added, stirred evenly, and after standing, the solid and liquid phases were separated, and the liquid phase was the Plantago seed extract.

5. An anti-glycation composition according to claim 1 or 2, characterized in that, The preparation method of pear juice fermentation product filtrate includes the following steps: Mix pears and pure water in a ratio of 1:(2-4), and blend them in a high-speed blender to obtain pear juice. Add the Lactobacillus culture medium to the pear juice at a weight ratio of 1:(25-35) and ferment at 35-38℃ for 36-60 hours. Adjust the pH of the fermentation broth to 6.5-7.0, and then separate the solid and liquid. The filtrate is the pear juice fermentation product filtrate.

6. The anti-glycation composition according to claim 5, characterized in that, The solid-liquid separation process includes: filtering the fermentation broth with 400-mesh gauze, centrifuging the filtrate at 8000-8500 rpm for 5-10 minutes; filtering the supernatant after centrifugation with a 5μm PP cotton core, and the filtrate is the pear juice fermentation product filtrate.

7. The use of the anti-glycation composition according to any one of claims 1-6 in the preparation of anti-glycation cosmetics.

8. A cosmetic product, characterized in that, The product includes the anti-glycation composition according to any one of claims 1-6; the anti-glycation composition is present in the cosmetic at a weight percentage of 5-50%.

9. The cosmetic product according to claim 8, characterized in that, It also includes the following components by weight percentage: The composition includes 5-15% polyol, 1-3% betaine, 0.1-0.5% carbomer, 0.5-1.5% auxiliaries, and 40-80% water.

10. The cosmetic product according to claim 9, characterized in that, The polyol is one or a combination of two or more of glycerol, butylene glycol, propylene glycol, dipropylene glycol or sorbitol; The additives are fragrances and preservatives.

Images