Traditional Chinese medicine compound preparation for treating hiccup and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine compound preparation for treating hiccup and a preparation method thereof. The invention provides a traditional Chinese medicine compound preparation for treating hiccup. The traditional Chinese medicine compound preparation is prepared from the following components in parts by mass: 10-14 parts of rhizoma pinelliae preparata, 10-14 parts of cortex magnoliae officinalis, 8-12 parts of radix scutellariae, 13-17 parts of kaki calyx, 13-17 parts of radix salviae miltiorrhizae, 8-12 parts of caulis perllae and 5-7 parts of liquorice root. Clinical research results show that the total effective rate of an experimental group treated by the hiccup-reducing and hiccup-stopping formula is as high as 90.9%, which is obviously higher than that of a control group treated by morpholine (68.18%). Through compatibility of rhizoma pinelliae preparata, cortex magnoliae officinalis, radix scutellariae and the like, the traditional Chinese medicine compound has the effects of clearing heat, eliminating phlegm, regulating qi and calming adverse-rising energy, can effectively relieve clinical symptoms of hiccup patients with qi depression and phlegm stagnation syndromes and promote healing, and shows remarkable advantages of traditional Chinese medicine syndrome differentiation and treatment in treatment of the hiccup and good clinical application value.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine compound preparation for treating hiccups and its preparation method. Background Technology

[0002] Hiccups, commonly known as "hiccups," are involuntary, intermittent spasmodic contractions of the diaphragm. While these symptoms are often brief and resolve spontaneously, their persistence or refractory nature causes significant discomfort and embarrassment, severely impacting eating, sleep, and quality of life. They can also be a clinical manifestation of certain serious organic diseases. Current Western medicine treatments primarily focus on symptomatic relief, such as physical stimulation, muscle relaxants, or psychotropic drugs. However, these methods often have limited effectiveness and may be accompanied by side effects such as drowsiness and fatigue. Therefore, seeking a safe, effective, and comprehensive alternative therapy is of significant clinical importance.

[0003] Traditional Chinese medicine (TCM) has a long history and unique theoretical advantages in treating functional gastrointestinal disorders. TCM believes that hiccups are primarily caused by the upward flow of stomach qi affecting the diaphragm, often related to factors such as improper diet, emotional imbalance, cold invading the stomach, or spleen and stomach weakness. Treatment emphasizes holistic regulation, with the fundamental principles being harmonizing the stomach, suppressing the upward flow of qi, and relieving diaphragmatic discomfort. Existing literature and clinical practice indicate that various single-herb TCM formulas and compound preparations show good potential in relieving diaphragmatic spasms and regulating gastrointestinal motility. This provides a solid theoretical and practical foundation for developing highly effective and stable compound preparations from TCM. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine compound preparation for treating hiccups and its preparation method.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a traditional Chinese medicine compound preparation for treating hiccups, comprising the following components in parts by weight: 10-14 parts of Pinellia ternata, 10-14 parts of Magnolia officinalis, 8-12 parts of Scutellaria baicalensis, 13-17 parts of Dioscorea opposita, 13-17 parts of Salvia miltiorrhiza, 8-12 parts of Perilla frutescens, and 5-7 parts of Glycyrrhiza uralensis.

[0006] This invention provides a method for preparing a traditional Chinese medicine compound preparation for treating hiccups, comprising the following steps: (1) Mix Pinellia ternata, Magnolia officinalis, Scutellaria baicalensis, Dioscorea opposita calyx, Salvia miltiorrhiza, Perilla frutescens stem and Glycyrrhiza uralensis to obtain material 1; mix material 1 with water, soak, decoct, and filter to obtain filtrate and residue; (2) The filter residue is mixed with water and boiled, and then filtered to obtain the decoction; (3) Simply mix the filtrate and the decoction.

[0007] Preferably, the mass ratio of material 1 to water in step (1) is 1:5~8.

[0008] Preferably, the soaking time in step (1) is 25 to 35 minutes.

[0009] Preferably, the simmering time in step (1) is 20-30 minutes.

[0010] Preferably, the mass ratio of the filter residue to water in step (2) is 1:2~3.

[0011] Preferably, the simmering time in step (2) is 5 to 10 minutes.

[0012] Compared with the prior art, the present invention has the following beneficial effects: The traditional Chinese medicine compound preparation provided by this invention is mainly used to treat: persistent hiccups, burning pain behind the sternum, belching or acid reflux, sticky phlegm in the throat that is difficult to cough up, bitter taste in the mouth, dry mouth, occasional cough with phlegm, pale red tongue with a slightly greasy yellow coating, and a wiry and slippery pulse. Western medicine diagnosis: reflux esophagitis. Traditional Chinese medicine diagnosis: hiccups or acid reflux (qi stagnation and phlegm obstruction syndrome). Treatment principle: regulate qi, relieve chest tightness, resolve phlegm, and clear heat.

[0013] The traditional Chinese medicine compound preparation provided by this invention is explained as follows: Pinellia ternata, Magnolia officinalis, and Ligusticum striatum promote the downward flow of qi and stop hiccups; Scutellaria baicalensis clears heat and dries dampness; Dioscorea opposita calyx descends rebellious qi, stops hiccups, strengthens the spleen, and resolves phlegm; Salvia miltiorrhiza promotes blood circulation, removes blood stasis, and relieves pain; Glycyrrhiza uralensis strengthens the spleen and regulates the middle jiao.

[0014] The results of this clinical study show that the total effective rate of the experimental group treated with the Tongjiang Zhie formula was as high as 90.9%, significantly higher than that of the control group treated with domperidone (68.18%). This traditional Chinese medicine compound, through the combination of Pinellia ternata, Magnolia officinalis, and Scutellaria baicalensis, works synergistically to clear heat, resolve phlegm, regulate qi, and relieve hiccups. It can effectively alleviate the clinical symptoms of patients with hiccups due to qi stagnation and phlegm obstruction, promote recovery, and demonstrate the significant advantages and good clinical application value of traditional Chinese medicine in the treatment of this disease. Detailed Implementation

[0015] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0016] Example 1

[0017] A method for preparing a traditional Chinese medicine compound for treating hiccups, comprising the following steps: (1) Mix 10 parts of Pinellia ternata, 10 parts of Magnolia officinalis, 8 parts of Scutellaria baicalensis, 13 parts of Dioscorea opposita, 13 parts of Salvia miltiorrhiza, 8 parts of Perilla frutescens and 5 parts of Glycyrrhiza uralensis to obtain material 1; mix material 1 with water at a mass ratio of 1:5 and soak for 25 minutes, decoct for 20 minutes, and filter to obtain filtrate and residue. (2) Mix the filter residue with water at a mass ratio of 1:2 and boil for 5 minutes, then filter to obtain the decoction; (3) Simply mix the filtrate and the decoction.

[0018] Example 2

[0019] A method for preparing a traditional Chinese medicine compound for treating hiccups, comprising the following steps: (1) Mix 14 parts of Pinellia ternata, 14 parts of Magnolia officinalis, 12 parts of Scutellaria baicalensis, 17 parts of Dioscorea opposita, 17 parts of Salvia miltiorrhiza, 12 parts of Perilla frutescens and 7 parts of Glycyrrhiza uralensis to obtain material 1; mix material 1 with water at a mass ratio of 1:8 and soak for 35 minutes, decoct for 30 minutes, and filter to obtain filtrate and residue. (2) Mix the filter residue with water at a mass ratio of 1:3 and boil for 10 minutes, then filter to obtain the decoction; (3) Simply mix the filtrate and the decoction.

[0020] Example 3

[0021] A method for preparing a traditional Chinese medicine compound for treating hiccups, comprising the following steps: (1) Mix 11 parts of Pinellia ternata, 11 parts of Magnolia officinalis, 9 parts of Scutellaria baicalensis, 14 parts of Dioscorea opposita, 14 parts of Salvia miltiorrhiza, 9 parts of Perilla frutescens and 6 parts of Glycyrrhiza uralensis to obtain material 1; mix material 1 with water at a mass ratio of 1:6 and soak for 27 min, decoct for 23 min, and filter to obtain filtrate and residue; (2) The filter residue and water are mixed at a mass ratio of 1:3 and boiled for 6 minutes, then filtered to obtain the decoction; (3) Simply mix the filtrate and the decoction.

[0022] Example 4

[0023] A method for preparing a traditional Chinese medicine compound for treating hiccups, comprising the following steps: (1) Mix 13 parts of Pinellia ternata, 13 parts of Magnolia officinalis, 11 parts of Scutellaria baicalensis, 16 parts of Dioscorea opposita, 16 parts of Salvia miltiorrhiza, 11 parts of Perilla frutescens and 6 parts of Glycyrrhiza uralensis to obtain material 1; mix material 1 with water at a mass ratio of 1:7 and soak for 29 minutes, decoct for 28 minutes, and filter to obtain filtrate and residue. (2) The filter residue and water are mixed at a mass ratio of 1:3 and boiled for 9 minutes, then filtered to obtain the decoction; (3) Simply mix the filtrate and the decoction.

[0024] Example 5

[0025] A method for preparing a traditional Chinese medicine compound for treating hiccups, comprising the following steps: (1) Mix 12 parts of Pinellia ternata, 12 parts of Magnolia officinalis, 10 parts of Scutellaria baicalensis, 15 parts of Dioscorea opposita, 15 parts of Salvia miltiorrhiza, 10 parts of Perilla frutescens and 6 parts of Glycyrrhiza uralensis to obtain material 1; mix material 1 with water at a mass ratio of 1:6 and soak for 30 min, decoct for 25 min, and filter to obtain filtrate and residue. (2) The filter residue and water are mixed at a mass ratio of 1:3 and boiled for 8 minutes, then filtered to obtain the decoction; (3) Simply mix the filtrate and the decoction.

[0026] Experimental Example 1

[0027] Forty-four patients with hiccups who visited the Department of Gastroenterology at the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from February 2022 to December 2023 were selected as the study subjects and randomly divided into an experimental group (n=22) and a control group (n=22) using a random number table. In the experimental group, there were 14 males and 8 females, aged 23–81 years, with a mean age of (56.1±10.6) years. In the control group, there were 15 males and 8 females, aged 25–80 years, with a mean age of (57.2±11.4) years. There were no statistically significant differences in general characteristics between the two groups (P>0.05), indicating comparability. Inclusion criteria: ① Meeting the diagnostic criteria for hiccups in *Internal Medicine of Traditional Chinese Medicine*; syndrome type: Qi stagnation and phlegm obstruction; ② Mild chronic superficial gastritis or chronic atrophic gastritis; ③ Age > 18 years; ④ Gender not limited. Exclusion criteria: ① Impaired consciousness; ② Accompanied by severe underlying diseases; ③ Accompanied by mental illness; ④ Patients with active peptic ulcers or those with dysplasia. Patients in the experimental group were treated with Tongjiang Zhie Fang (prepared according to the method in Example 5), 150ml twice daily. One course of treatment lasted 5 days, and a total of one course was administered. Patients in the control group were treated with Domperidone, 10mg orally three times daily. One course of treatment lasted 7 days.

[0028] The clinical efficacy of the two groups of patients was compared after 7 days of treatment. The efficacy evaluation criteria included three categories: cured, effective, and ineffective. Cured was defined as the disappearance of patient symptoms and the cessation of hiccups; effective was defined as significant improvement in patient symptoms and occasional hiccups; ineffective was defined as no improvement in patient symptoms.

[0029] Overall effective rate of treatment = (number of cured cases + number of effective cases) / total number of cases × 100%.

[0030] Treatment results: Experimental group: 9 cases were cured, 11 cases were effective, and 2 cases were ineffective, with a total effective rate of 90.9%; Control group: 6 cases were cured, 9 cases were effective, and 7 cases were ineffective, with a total effective rate of 68.18%.

[0031] The results of this clinical study show that the total effective rate of the experimental group treated with the Tongjiang Zhie formula was as high as 90.9%, significantly higher than that of the control group treated with domperidone (68.18%). This traditional Chinese medicine compound, through the combination of Pinellia ternata, Magnolia officinalis, and Scutellaria baicalensis, works synergistically to clear heat, resolve phlegm, regulate qi, and relieve hiccups. It can effectively alleviate the clinical symptoms of patients with hiccups due to qi stagnation and phlegm obstruction, promote recovery, and demonstrate the significant advantages and good clinical application value of traditional Chinese medicine in the treatment of this disease.

[0032] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine compound preparation for treating hiccups, characterized in that, The composition comprises the following components in mass fraction: Qingbanxia 10-14 parts, Hupu 10-14 parts, Huangqi 8-12 parts, Qitidi 13-17 parts, Danshen 13-17 parts, Sugeng 8-12 parts, and Gancao 5-7 parts.

2. The preparation method of the traditional Chinese medicine compound preparation for treating hiccups according to claim 1, characterized in that, The method comprises the following steps: (1) mixing Qingbanxia, Hupu, Huangqi, Qitidi, Danshen, Sugeng, and Gancao to obtain material 1; mixing the material 1 with water to soak, decocting, and filtering to obtain filtrate and residue; (2) mixing the residue with water to decoct, and filtering to obtain decocted liquid; (3) mixing the filtrate and the decocted liquid.

3. The production method according to claim 2, characterized by, In step (1), the mass ratio of the material 1 to water is 1:5-8.

4. The production method according to claim 2, characterized by, In step (1), the soaking time is 25-35 min.

5. The preparation method according to claim 2, characterized in that, In step (1), the decocting time is 20-30 min.

6. The preparation method according to claim 2, characterized in that, In step (2), the mass ratio of the residue to water is 1:2-3.

7. The preparation method according to claim 2, characterized in that, In step (2), the decocting time is 5-10 min.