Human body lubricant containing hyaluronic acid for vagina lubrication as well as preparation method and application of human body lubricant

Abstract

The invention provides a human body lubricant containing hyaluronic acid for vagina lubrication and a preparation method and application thereof, the human body lubricant is prepared from the following raw materials in parts by weight: 0.5-2.5 parts of sodium hyaluronate, 6-10 parts of plant extract, 0.5-0.8 part of alpha-ketoglutaric acid, 5-8 parts of 1, 2-propylene glycol, 10-15 parts of glycerol and 3-5 parts of arginine modified hydroxyethyl cellulose, 1-3 parts of a pH regulator, 0.05-0.1 part of a preservative and 60-80 parts of purified water. The human body lubricant disclosed by the invention has a good lubricating effect, is not sticky and greasy, reduces a dynamic friction coefficient, is good in moisture retention, reduces dryness of women caused by lack of secretions, improves sexual life experience, has no side effects, is high in safety and has no irritation to vaginal mucosa. The pH value is consistent with the normal pH value of the female vagina, the balance of the micro-ecological environment of the female vagina is maintained, various venereal disease pathogens can be quickly killed, venereal disease transmission is prevented, female gynecological diseases in sexual life are prevented, and inflammations such as pruritus and peculiar smell at private parts are prevented.

Description

Technical Field

[0001] This invention relates to the field of lubricants, and in particular to a hyaluronic acid-containing human lubricant for vaginal lubrication, its preparation method, and its application. Background Technology

[0002] As women transition from childbearing age to old age, declining ovarian function leads to decreased vaginal secretions, resulting in vaginal dryness and reduced reproductive tract secretions. Currently, most natural rubber condoms on the market use methyl silicone oil as a lubricant. Because methyl silicone oil is non-volatile and insoluble in water, it doesn't readily absorb moisture from the skin, causing a greasy feeling. Furthermore, silicone oil lubricants have a high coefficient of friction, making it difficult to wash off the grease. Prolonged retention in the folds of the condom can weaken the body's immune system, creating favorable conditions for bacterial growth and increasing the risk of reproductive infections, causing itching, odor, and other inflammatory symptoms.

[0003] Therefore, there is a need to develop a human lubricant that can reduce dryness in women caused by lack of secretions, and prevent inflammation such as itching and odor caused by gynecological infections during sexual intercourse. It should have no side effects, be highly safe, and enhance the sexual experience, which would be of practical significance. Summary of the Invention

[0004] In view of this, the present invention proposes a human lubricant containing hyaluronic acid for vaginal lubrication, its preparation method and application.

[0005] The technical solution of this invention is implemented as follows:

[0006] A hyaluronic acid-containing personal lubricant for vaginal lubrication, comprising the following ingredients by weight: 0.5-2.5 parts sodium hyaluronate, 6-10 parts plant extract, 0.5-0.8 parts α-ketoglutarate, 5-8 parts 1,2-propanediol, 10-15 parts glycerin, 3-5 parts arginine-modified hydroxyethyl cellulose, 1-3 parts pH adjuster, 0.05-0.1 parts preservative, and 60-80 parts purified water.

[0007] Furthermore, the plant extract consists of sea grape extract and aloe vera extract in a mass ratio of 3-5:1.

[0008] Furthermore, the sodium hyaluronate is composed of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate in a mass ratio of 1-3:3-5, wherein the high molecular weight sodium hyaluronate has a molecular weight of 1600-1800 kDa and the low molecular weight sodium hyaluronate has a molecular weight of 20-50 kDa.

[0009] Furthermore, the α-ketoglutarate is α-ketoglutarate / plant extract containing α-ketoglutarate / fermentation product containing α-ketoglutarate.

[0010] Furthermore, the preparation method of the arginine-modified hydroxyethyl cellulose includes: dispersing hydroxyethyl cellulose in water for 10-20 min, adding arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide, adjusting the pH to 4-5, reacting at 30-40℃ for 8-12 h, adjusting the pH to 9-10, filtering, concentrating under reduced pressure, and cooling to 1-5℃ to obtain arginine-modified hydroxyethyl cellulose;

[0011] The solid-liquid ratio of the hydroxyethyl cellulose to water is 1:10-15 g / mL; the molar ratio of the hydroxyethyl cellulose to arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide is 1:1.2-1.4:1-3:1-3.

[0012] Furthermore, the preservative is methylparaben and propylparaben in a mass ratio of 1:1-3.

[0013] Furthermore, the pH adjuster maintains the pH value of the human lubricant at 4-6.

[0014] A method for preparing a hyaluronic acid-containing human lubricant for vaginal lubrication includes the following steps: dissolving sodium hyaluronate in 50-60 wt% of purified water; sequentially adding plant extracts, α-ketoglutaric acid, 1,2-propanediol, glycerol, and amino acid-modified hydroxyethyl cellulose; ultrasonic treatment; adding a pH adjuster, preservative, and the remaining water; microwave irradiation treatment; and homogenization to obtain a human lubricant with a viscosity of 500-1500 MPa·s.

[0015] Furthermore, the ultrasonic treatment is performed at 300-500 rpm and 40-60℃ for 20-30 minutes; the microwave radiation treatment is performed at 500-700W and 60-80℃ for 10-20 minutes; and the homogenization is performed by first shearing and dispersing at 2000-3000 rpm for 5-8 minutes, followed by shearing and dispersing at 1000-2000 rpm for 10-15 minutes.

[0016] The application of the aforementioned human lubricant as a lubricant for condoms.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] 1. The human lubricant of this invention has excellent lubrication effects, is non-sticky, reduces the coefficient of dynamic friction, has good moisturizing properties, reduces dryness caused by lack of secretions in women, and enhances the sexual experience. It has no side effects, is highly safe, and does not irritate the vaginal mucosa.

[0019] 2. The human lubricant of this invention has the same pH value as the normal pH value of the female vagina, maintaining the balance of the female vaginal microecological environment. At the same time, it can quickly kill Escherichia coli, Candida albicans, and Staphylococcus aureus, prevent the spread of sexually transmitted diseases, prevent women from contracting gynecological diseases during sexual intercourse, and prevent inflammation such as itching and odor in the private parts. Detailed Implementation

[0020] To better understand the technical content of this invention, specific embodiments are provided below to further illustrate the invention.

[0021] Unless otherwise specified, the experimental methods used in the embodiments of this invention are all conventional methods.

[0022] Unless otherwise specified, all materials and reagents used in the embodiments of this invention are commercially available.

[0023] Example 1

[0024] A hyaluronic acid-containing personal lubricant for vaginal lubrication comprises, by weight, the following ingredients: 1.5 parts sodium hyaluronate (1700kDa high molecular weight sodium hyaluronate and 35kDa low molecular weight sodium hyaluronate in a mass ratio of 1:2), 8 parts plant extracts (sea grape extract and aloe vera extract in a mass ratio of 4:1), 0.7 parts α-ketoglutarate, 7 parts 1,2-propanediol, 13 parts glycerin, 4 parts arginine-modified hydroxyethyl cellulose, 2 parts pH adjuster, 0.08 parts preservative (methylparaben and propylparaben in a mass ratio of 1:2), and 70 parts purified water.

[0025] The preparation method of arginine-modified hydroxyethyl cellulose includes: dispersing hydroxyethyl cellulose in water for 15 min according to a solid-liquid ratio of 1:13 g / mL, then adding arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide, with a molar ratio of 1:1.3:2:2 for hydroxyethyl cellulose to arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide. The pH is adjusted to 4.5±0.1, and the reaction is carried out at 35℃ for 10 h. The pH is then adjusted to 9.5±0.1, filtered, concentrated under reduced pressure, and cooled to 3℃ to obtain arginine-modified hydroxyethyl cellulose.

[0026] The preparation method of the above-mentioned hyaluronic acid-containing human lubricant for vaginal lubrication includes the following steps: dissolving sodium hyaluronate in 55wt% of the formulated amount of purified water, sequentially adding plant extracts, α-ketoglutarate, 1,2-propanediol, glycerol, and amino acid-modified hydroxyethyl cellulose, ultrasonically treating (400 rpm, 50℃) for 25 min, adding pH adjuster, preservative, and the remaining water to maintain the pH value of the human lubricant at 5.0±0.1, treating with microwave radiation (600W, 70℃) for 15 min, homogenizing (first shearing and dispersing at 2500 rpm for 7 min, then shearing and dispersing at 1500 rpm for 12 min), to obtain a human lubricant with a viscosity of 1000±50 MPa·s.

[0027] Example 2

[0028] A hyaluronic acid-containing personal lubricant for vaginal lubrication comprises, by weight, the following ingredients: 0.5 parts sodium hyaluronate (1600kDa high molecular weight sodium hyaluronate and 20kDa low molecular weight sodium hyaluronate in a mass ratio of 1:3), 6 parts plant extracts (sea grape extract and aloe vera extract in a mass ratio of 3:1), 0.5 parts plant extract containing α-ketoglutarate, 5 parts 1,2-propanediol, 10 parts glycerin, 3 parts arginine-modified hydroxyethyl cellulose, 1 part pH adjuster, 0.05 parts preservative (methylparaben and propylparaben in a mass ratio of 1:1), and 60 parts purified water.

[0029] The preparation method of arginine-modified hydroxyethyl cellulose includes: dispersing hydroxyethyl cellulose in water for 10 min according to a solid-liquid ratio of 1:10 g / mL, then adding arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide, with a molar ratio of 1:1.2:1:1 for hydroxyethyl cellulose, arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide. The pH is adjusted to 4±0.1, and the reaction is carried out at 30℃ for 8 h. The pH is then adjusted to 9.1±0.1, filtered, concentrated under reduced pressure, and cooled to 1℃ to obtain arginine-modified hydroxyethyl cellulose.

[0030] The preparation method of the above-mentioned hyaluronic acid-containing human lubricant for vaginal lubrication includes the following steps: dissolving sodium hyaluronate in 50-60 wt% of the formulated amount of purified water; sequentially adding plant extracts, plant extracts containing α-ketoglutarate, 1,2-propanediol, glycerol, and amino acid-modified hydroxyethyl cellulose; ultrasonic treatment (300 rpm, 40℃) for 20 min; adding pH adjuster, preservative, and the remaining water to maintain the pH value of the human lubricant at 4.1±0.1; microwave radiation treatment (500W, 60℃) for 10 min; homogenization (first shearing and dispersing at 2000 rpm for 5 min, then shearing and dispersing at 1000 rpm for 10-15 min) to obtain a human lubricant with a viscosity of 550±50 MPa·s.

[0031] Example 3

[0032] A hyaluronic acid-containing personal lubricant for vaginal lubrication comprises, by weight, the following ingredients: 2.5 parts sodium hyaluronate (1800kDa high molecular weight sodium hyaluronate and 50kDa low molecular weight sodium hyaluronate in a mass ratio of 3:5), 10 parts plant extracts (sea grape extract and aloe vera extract in a mass ratio of 5:1), 0.8 parts fermentation product containing α-ketoglutarate, 8 parts 1,2-propanediol, 15 parts glycerin, 5 parts arginine-modified hydroxyethyl cellulose, 3 parts pH adjuster, 0.1 parts preservative (methylparaben and propylparaben in a mass ratio of 1:3), and 80 parts purified water.

[0033] The preparation method of arginine-modified hydroxyethyl cellulose includes: dispersing hydroxyethyl cellulose in water for 20 min at a solid-liquid ratio of 1:15 g / mL, then adding arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide, with a molar ratio of 1:1.4:3:3 for hydroxyethyl cellulose, arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide. The pH is adjusted to 4.9±0.1, and the reaction is carried out at 40℃ for 12 h. The pH is then adjusted to 9.9±0.1, filtered, concentrated under reduced pressure, and cooled to 5℃ to obtain arginine-modified hydroxyethyl cellulose.

[0034] The preparation method of the above-mentioned hyaluronic acid-containing human lubricant for vaginal lubrication includes the following steps: dissolving sodium hyaluronate in 60wt% of the formulated amount of purified water, then sequentially adding plant extracts, fermentation products containing α-ketoglutarate, 1,2-propanediol, glycerol, and amino acid-modified hydroxyethyl cellulose, ultrasonically treating (500 rpm, 60℃) for 30 min, adding pH adjuster, preservative, and the remaining water to maintain the pH value of the human lubricant at 5.9±0.1, microwave irradiation (700W, 80℃) for 20 min, homogenizing (first shearing and dispersing at 3000 rpm for 8 min, then shearing and dispersing at 2000 rpm for 15 min) to obtain a human lubricant with a viscosity of 1450±50 MPa·s.

[0035] Comparative Example 1

[0036] The difference from Example 1 is that the amount of raw materials used is different, but everything else is the same as Example 1.

[0037] This comparative example of a hyaluronic acid-containing human lubricant for vaginal lubrication comprises, by weight, the following ingredients: 3 parts sodium hyaluronate, 5 parts plant extract, 0.3 parts α-ketoglutarate, 9 parts 1,2-propanediol, 17 parts glycerin, 2 parts arginine-modified hydroxyethyl cellulose, 4 parts pH adjuster, 0.04 parts preservative, and 90 parts purified water.

[0038] Comparative Example 2

[0039] The difference from Example 1 is that the sodium hyaluronate used is 1700kDa high molecular weight sodium hyaluronate, while the rest is the same as in Example 1.

[0040] Comparative Example 3

[0041] The difference from Example 1 is that all plant extracts are aloe vera extracts, i.e., 8 parts of aloe vera extract, while the rest is the same as Example 1.

[0042] Comparative Example 4

[0043] The difference from Example 1 is that the raw materials lack α-ketoglutarate, and the missing raw materials are allocated to other components in proportion, otherwise it is the same as Example 1.

[0044] Comparative Example 5

[0045] The difference from Example 1 is that the arginine-modified hydroxyethyl cellulose is replaced with hydroxyethyl cellulose, otherwise it is the same as Example 1.

[0046] Comparative Example 6

[0047] The difference from Example 1 is that the homogenization process was performed by shear dispersion at 2500 rpm for 19 min, while the rest was the same as Example 1.

[0048] The preparation method of the hyaluronic acid-containing human lubricant for vaginal lubrication in this comparative example includes the following steps: adding sodium hyaluronate to 55wt% of the formulated amount of purified water to dissolve it, then adding plant extract, α-ketoglutarate, 1,2-propanediol, glycerol and amino acid-modified hydroxyethyl cellulose in sequence, ultrasonic treatment (400 rpm, 50℃) for 25 min, adding pH adjuster, preservative and the remaining water to maintain the pH value of the human lubricant at 5±0.1, microwave radiation treatment (600W, 70℃) for 15 min, homogenization (shear dispersion at 2500 rpm for 19 min) to obtain a human lubricant with a viscosity of 1000±50 MPa·s.

[0049] Test case

[0050] 1. Lubricity

[0051] The human lubricants of Examples 1-3 and Comparative Examples 1-6 were subjected to dynamic friction coefficient testing (according to GB / T10006-2021 Determination of the coefficient of friction of plastic films and sheets). Specifically, the surface of the latex condom wetted with lubricant was used as the test surface, and the friction pair surface was pigskin. The condoms were placed at 40°C and subjected to a linear abrasion test in a constant temperature and humidity chamber (40°C, relative humidity 30%). The friction speed was 60 times / min. After 3 minutes, the dynamic friction coefficient of the condom friction surface was tested. The results are summarized in Table 1.

[0052] 2. Moisturizing properties

[0053] 5g of the human body lubricant from Examples 1-3 and Comparative Examples 1-6 was weighed and added to a weighing bottle (without a cap). The bottle was placed in a constant temperature and humidity chamber (40℃, 30% relative humidity) for 24 hours. After 24 hours, the bottle was removed and weighed again, and the mass difference was calculated. The smaller the mass difference, the better the moisturizing effect. The results are summarized in Table 1.

[0054] 3. Vaginal stimulation test

[0055] According to GB / T 16886.10-2017 Biological Evaluation of Medical Devices Part 10: Irritation and Skin Sensitization Tests, vaginal irritation tests were performed on rabbits. The evaluation criteria were as follows: average score of 0 points, no irritation; average score of 1-4 points, very mild irritation; average score of 5-8 points, mild irritation; average score of 9-11 points, toxic irritation; and average score of 12-16 points, severe irritation. The results are summarized in Table 1.

[0056] 4. Sensitization test

[0057] Skin sensitization tests were conducted according to ISO 1099310:2010, with evaluation criteria as follows: Level 0, no sensitization; Level 1, mild sensitization; Level 2, moderate sensitization; Level 3, severe sensitization. The results are summarized in Table 1.

[0058] From the table

[0059] Table 1

[0060] sample coefficient of kinetic friction Moisturizing vaginal stimulation test Sensitization test Example 1 0.18 79.4 0 0 Example 2 0.21 77.3 0 0 Example 3 0.23 78.6 0 0 Comparative Example 1 0.47 64.7 0 0 Comparative Example 2 0.44 61.1 0 0 Comparative Example 3 0.39 58.9 0 0 Comparative Example 4 0.57 55.8 0 0 Comparative Example 5 0.61 55.1 0 0 Comparative Example 6 0.69 54.7 0 0

[0061] As shown in Table 1, the human lubricants prepared in Examples 1-3 of this invention have excellent lubrication effects, reduced dynamic friction coefficient, greatly enhanced sexual experience, and high moisturizing properties, reducing dryness caused by insufficient vaginal secretions. They have no side effects, high safety, are non-allergenic, and do not irritate the vaginal mucosa. In contrast, the human lubricants prepared in Comparative Examples 1-6 exhibit varying degrees of decreased functionality, increased dynamic friction coefficient, insufficient lubrication, and decreased moisturizing properties, leading to dryness and odor in the genital area, and a sharp decline in sexual experience, making them unsuitable for real-life use.

[0062] 5. Antibacterial test

[0063] Test strains: Escherichia coli, Candida albicans, Staphylococcus aureus;

[0064] Specific method: First, wash the 24-hour slant culture of the test bacteria with PBS to prepare a bacterial suspension (the required concentration is: 100 μL is dropped onto the control sample, and the recovered bacterial count is 1 × 10⁻⁶). 4 -9×10 4 (CFU / tablet). Take 4 sample tablets (50px × 75px) and 4 control tablets (same material and size as the sample, but without antibacterial material and sterilized). Take the above bacterial suspension and add 100μL to each sample tablet and control tablet, spread evenly, and let it incubate for 10 min. Use sterile forceps to put the tablets into test tubes containing 5mL PBS, mix thoroughly, and dilute appropriately. Then take 2-3 dilutions, take 0.5mL of each, place them in two petri dishes, pour 5mL of nutrient agar medium cooled to 40-45℃ into each dish, rotate the petri dish to make it evenly mixed, and after the agar solidifies, invert the plate and incubate at 35℃±2℃ for 48 h. Count the viable colonies.

[0065] The experiment was repeated three times, and the inhibition rate was calculated as follows: Inhibition rate % = (Average colony count of control sample - Average colony count of test sample) / Average colony count of control sample × 100%

[0066] The antibacterial effects of Examples 1-3 and Comparative Examples 1-6 against Escherichia coli, Candida albicans, and Staphylococcus aureus were tested. The action time was 5 minutes, and the test results are shown in Table 2.

[0067] Table 2

[0068] sample Candida albicans inhibition rate Escherichia coli inhibition rate Staphylococcus aureus inhibition rate Example 1 >99％ >99％ >99％ Example 2 >99％ >99％ >99％ Example 3 >99％ >99％ >99％ Comparative Example 1 80.4％ 82.7％ 81.9％ Comparative Example 2 84.7％ 85.4％ 85.7％ Comparative Example 3 60.8％ 61.4％ 62.6％ Comparative Example 4 58.7％ 59.6％ 57.1％ Comparative Example 5 89.7％ 87.7％ 87.4％ Comparative Example 6 82.4％ 80.2％ 81.5％

[0069] As shown in Table 2, the human lubricants prepared in Examples 1-3 of this invention can rapidly kill sexually transmitted pathogens (Escherichia coli, Candida albicans, Staphylococcus aureus), preventing women from being infected with gynecological diseases during sexual intercourse, thus preventing itching and odor. Compared to Example 1, the bactericidal effect of the human lubricants obtained in Comparative Examples 1-6 is reduced.

[0070] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A hyaluronic acid-containing personal lubricant for vaginal lubrication, characterized in that, The ingredients, by weight, include the following: 0.5-2.5 parts sodium hyaluronate, 6-10 parts plant extract, 0.5-0.8 parts α-ketoglutarate, 5-8 parts 1,2-propanediol, 10-15 parts glycerol, 3-5 parts arginine-modified hydroxyethyl cellulose, 1-3 parts pH adjuster, 0.05-0.1 parts preservative, and 60-80 parts purified water.

2. A hyaluronic acid-containing personal lubricant for vaginal lubrication as described in claim 1, characterized in that, The plant extract consists of sea grape extract and aloe vera extract in a mass ratio of 3-5:

1.

3. A hyaluronic acid-containing personal lubricant for vaginal lubrication as described in claim 1, characterized in that, The sodium hyaluronate is composed of high molecular weight sodium hyaluronate and low molecular weight sodium hyaluronate in a mass ratio of 1-3:3-5, wherein the molecular weight of the high molecular weight sodium hyaluronate is 1600-1800 kDa and the molecular weight of the low molecular weight sodium hyaluronate is 20-50 kDa.

4. A hyaluronic acid-containing personal lubricant for vaginal lubrication as described in claim 1, characterized in that, The α-ketoglutarate is α-ketoglutarate / plant extracts containing α-ketoglutarate / fermentation products containing α-ketoglutarate.

5. A hyaluronic acid-containing personal lubricant for vaginal lubrication as described in claim 1, characterized in that, The preparation method of the arginine-modified hydroxyethyl cellulose includes: dispersing hydroxyethyl cellulose in water for 10-20 min, adding arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide, adjusting the pH to 4-5, reacting at 30-40℃ for 8-12 h, adjusting the pH to 9-10, filtering, concentrating under reduced pressure, and cooling to 1-5℃ to obtain arginine-modified hydroxyethyl cellulose; The solid-liquid ratio of the hydroxyethyl cellulose to water is 1:10-15 g / mL; the molar ratio of the hydroxyethyl cellulose to arginine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxy-succinimide is 1:1.2-1.4:1-3:1-3.

6. A hyaluronic acid-containing personal lubricant for vaginal lubrication as described in claim 1, characterized in that, The preservative is methylparaben and propylparaben in a mass ratio of 1:1-3.

7. A hyaluronic acid-containing personal lubricant for vaginal lubrication as described in claim 1, characterized in that, The pH adjuster is used to maintain the pH value of the human lubricant at 4-6.

8. A method for preparing a hyaluronic acid-containing human lubricant for vaginal lubrication as described in claim 1, characterized in that, The specific steps include: adding sodium hyaluronate to 50-60 wt% of the formulated amount of purified water, dissolving it, then sequentially adding plant extracts, α-ketoglutarate, 1,2-propanediol, glycerol, and amino acid-modified hydroxyethyl cellulose, ultrasonic treatment, adding pH adjuster, preservative, and the remaining water, microwave irradiation treatment, homogenization, and obtaining a human lubricant with a viscosity of 500-1500 MPa·s.

9. A method for preparing a hyaluronic acid-containing human lubricant for vaginal lubrication as described in claim 8, wherein the ultrasonic treatment is performed at 300-500 rpm and 40-60°C for 20-30 min; the microwave radiation treatment is performed at 500-700 W and 60-80°C for 10-20 min; and the homogenization is performed by first shearing and dispersing at 2000-3000 rpm for 5-8 min, followed by shearing and dispersing at 1000-2000 rpm for 10-15 min.

10. The use of the personal lubricant according to any one of claims 1-7 as a lubricant for condoms.