Wet tissue liquid for improving hemorrhoid symptoms, wet tissue, production method and application

Abstract

The invention discloses a wet tissue liquid for improving hemorrhoid symptoms, a wet tissue, a production method and application, the wet tissue liquid comprises asiaticoside, a sophora flower charcoal extract, bisabolol, a honeysuckle flower extract, a rosemary extract, ceramide NP, D-panthenol, potassium cocoyl glycinate, citric acid, sodium citrate and purified water, and the wet tissue comprises spunlace non-woven fabric. The wet tissue liquid is loaded on a non-woven fabric, the production process of the wet tissue liquid comprises a pretreatment stage, a preparation stage and a filtering stage, and the produced wet tissue liquid is applied to hygienic products for improving hemorrhoid symptoms. The sophora flower charcoal extract is used for the haemorrhoids wet tissue liquid to achieve the effects of stopping bleeding, cleaning and mildly easing pain; double natural extracts are compounded to replace preservatives, traditional single symptom relief is upgraded to symptom treatment, mucous membrane repair and barrier protection, disease deterioration and recurrence risks are reduced, and the composition is free of chemical preservatives, free of irritant surface activity and suitable for being used by people with hemorrhoid symptoms.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of sanitary cleaning, and particularly relates to a wet tissue liquid for improving hemorrhoid symptoms, a wet tissue, a production method and application. BACKGROUND

[0002] Toilet wet tissue is a cleaning product specially designed for toilet, compared with traditional dry toilet paper, its core value lies in more thorough cleaning ability, more gentle skin feeling and more convenient use experience. With the increasing demand of consumers for personal hygiene and convenience, toilet wet tissue has become a commonly used product in home and outdoor scenes.

[0003] However, the existing toilet wet tissue for hemorrhoid patients has many deficiencies, mainly in: The existing formula mainly uses menthol components such as menthol and menthol lactate to achieve analgesic and soothing effect. The skin cold receptors are activated to quickly produce a cooling sensation, relieving burning pain.

[0004] Some traditional Chinese medicine background brands such as Ma Yinglong add artificial musk, ox gall and borneol to strengthen the astringent and analgesic effect.

[0005] Traditional raw materials are mainly used in hemostatic components, and traditional hemostatic raw materials such as sophora flower extract, gallnut and imperata cylindrical are mainly used to achieve hemostatic effect by promoting the activation of thrombin. Although some wet tissues use sophora flower and other raw materials to have hemostatic function, they need to add cleaning components such as SLES to remove anal area dirt, resulting in component stacking stimulation; the hemostatic effect time is generally 15-20 minutes, which cannot meet the demand of acute bleeding.

[0006] The anti-inflammatory component is a single plant extract, the coverage is narrow, and the mainstream uses single anti-inflammatory components such as baicalin, cortex phellodendri extract and chamomile extract to relieve redness, itching and itching by inhibiting the release of inflammatory factors. Such design only targets inflammation caused by bacterial infection, and is ineffective for anal itching caused by fungi such as Candida albicans; and lacks mucosal repair function, and cannot solve the core problem of repeated damage of hemorrhoids.

[0007] 5. More than 90% of the existing formula relies on chemical preservatives to extend the shelf life, and no antioxidant synergistic component is added. The active ingredients are easy to oxidize and lose effectiveness, and the shelf life is less than 6 months.

[0008] The existing formula generally has the tendency of heavy symptomatic treatment and light basic protection, therefore, a wet tissue liquid formula specially for improving hemorrhoid symptoms is needed. SUMMARY

[0009] The purpose of the present application is to solve the problems existing in the prior art, and to provide a wet tissue liquid for improving hemorrhoid symptoms, which uses Sophora japonica charcoal extract to achieve hemostasis, cleaning, and mild analgesia in hemorrhoid wet tissue liquid; uses double natural extract compound instead of preservative, upgrades from traditional single symptom relief to symptom treatment, mucosa repair, and barrier protection, reduces the risk of disease aggravation and recurrence, and is suitable for people with hemorrhoid symptoms without chemical preservatives and irritation.

[0010] To achieve the above purpose, the present application adopts the following technical scheme: a wet tissue liquid for improving hemorrhoid symptoms, comprising, calculated in percentage by mass: total glycosides of Centella asiatica 0.1-0.5 parts Sophora japonica charcoal extract 0.3-0.8 parts Bisabolol 0.05-0.2 parts honeysuckle extract 0.2-0.6 parts rosemary extract 0.1-0.4 parts ceramide NP 0.03-0.1 parts D-panthenol 0.5-1.5 parts potassium cocoyl glycinate 1.0-2.0 parts citric acid 0.01-0.03 parts sodium citrate 0.02-0.05 parts purified water balance.

[0011] As a further description of the above technical scheme: comprising, calculated in percentage by mass: total glycosides of Centella asiatica 0.3 parts Sophora japonica charcoal extract 0.5 parts Bisabolol 0.1 parts honeysuckle extract 0.4 parts rosemary extract 0.2 parts ceramide NP 0.05 parts D-panthenol 1.0 parts potassium cocoyl glycinate 1.5 parts citric acid 0.02 parts sodium citrate 0.03 parts purified water 95 parts.

[0012] As a further description of the above technical scheme: the content of chlorogenic acid in the honeysuckle extract is ≥5%.

[0013] As a further description of the above technical scheme: the content of salvia acid in the rosemary extract is ≥10%.

[0014] A preparation method of a wet tissue liquid for improving hemorrhoid symptoms, for preparing the wet tissue liquid for improving hemorrhoid symptoms, comprising the following operation steps: S1: pretreatment stage: (1) The purified water is treated by reverse osmosis equipment to ensure that the electrical conductivity is ≤10 μS / cm, and is cooled to 40-45℃ after boiling for standby; (2) The Sophora flower charcoal extract is removed from coarse particles and dispersed into a paste with 5 times the weight of preheated purified water; (3) The ceramide NP is mixed with D-panthenol, 2 times the weight of preheated purified water is added, and stirring is performed until a transparent dispersion liquid is formed; S2: preparation stage: SS1: The pre-processed purified water is added to the stirring tank, stirring is performed, and the rotating speed is set to 150 r / min; the formula amount of potassium cocoyl glycinate is added, and stirring is performed for 3 minutes until it is completely transparent; The D-panthenol is added, the stirring rotating speed is set to 300 r / min, and the time is 2 minutes until it is uniform; SS2: The temperature of the stirring tank is kept at 40-45℃, the pre-processed Sophora flower charcoal extract paste is added, the rotating speed is set to 350 r / min, and stirring is performed for 5 minutes, while the ultrasonic dispersion is started to ensure that the charcoal particles are uniformly suspended; the total glycosides of Centella asiatica, honeysuckle extract, and rosemary extract are sequentially added, and the rotating speed is set to 300 r / min after each component is added to perform stirring until it is completely dissolved; The pre-processed ceramide NP dispersion liquid is added, the rotating speed is set to 200 r / min, and stirring is performed until it is uniformly dispersed; SS3: The temperature of the stirring tank is reduced to 30-35℃, the bisabolol is added, and stirring is performed at a rotating speed of 180 r / min until there is no oil flower; SS4: The citric acid solution is slowly added dropwise with a dropper, and the pH is monitored while adding, and the pH is adjusted to 5.8-6.2; the formula amount of sodium citrate is added, the stirring rotating speed is 250 r / min, stirring is performed for 3 minutes, and the pH is detected to be 6.0±0.1 at the same time; The purified water is added, and stirring is performed at a rotating speed of 300 r / min; S3: filtration stage: stop stirring, filter the liquid through a 0.45 μm water system filter membrane, and collect the filtrate.

[0015] A wet tissue for improving hemorrhoid symptoms, comprising the wet tissue liquid for improving hemorrhoid symptoms, characterized in that the wet tissue further comprises a spunlace non-woven fabric, and the wet tissue liquid for improving hemorrhoid symptoms is loaded on the non-woven fabric.

[0016] Further description of the above technical solution: according to the mass percentage, the mass percentage of the wet tissue liquid to the spunlace non-woven fabric is 1:3.

[0017] An application of a hemorrhoid symptom improving wet tissue liquid, comprising the hemorrhoid symptom improving wet tissue liquid, the application of the hemorrhoid symptom improving wet tissue liquid to a sanitary product for improving hemorrhoid symptoms.

[0018] An application of a hemorrhoid symptom improving wet tissue liquid, comprising the hemorrhoid symptom improving wet tissue liquid, the application of the hemorrhoid symptom improving wet tissue liquid to a sanitary product for improving hemorrhoid symptoms.

[0019] By adopting the technical scheme, the application has the following beneficial effects: (1) Component innovation: the Sophora japonica charcoal extract is used in the hemorrhoid wet tissue liquid for the first time, achieving hemostasis and cleaning; the myrrh alcohol is used, which can achieve mild analgesia; the double natural extract is used to replace the preservative, filling the technical blank of the preservative-free formula. (2) Function upgrade: from the traditional single symptom relief to the symptom treatment, mucosa repair and barrier protection, reducing the risk of disease aggravation and recurrence. (3) Safety improvement: no chemical preservative, no irritating surface active agent and no high-stimulating analgesic component, suitable for sensitive people with hemorrhoids and the like. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the application will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the application.

[0021] The application is described in detail by the following embodiments: Embodiment 1

[0022] A hemorrhoid symptom improving wet tissue liquid, comprising, in percentage by mass: Total Gossypium 0.1~0.5 parts Sophora japonica charcoal extract 0.3~0.8 parts Myrrh alcohol 0.05~0.2 parts Honeysuckle extract 0.2~0.6 parts Rosemary extract 0.1~0.4 parts Ceramide NP 0.03~0.1 parts D-panthenol 0.5~1.5 parts Potassium cocoyl glycinate 1.0~2.0 parts Citric acid 0.01~0.03 parts Sodium citrate 0.02~0.05 parts Purified water balance.

[0023] In the formula of the present embodiment, purified water is selected as the solvent for dispersing the active ingredients. Other effective ingredients are selected based on the anti-inflammatory, mucosa repairing, and nevus hyperplasia inhibiting effects of total asiaticoside. In order to make total asiaticoside easily soluble in water, total asiaticoside powder with a purity of greater than or equal to 90% is selected.

[0024] Sophora flower charcoal extract can quickly stop bleeding and adsorb anal perianal dirt, and has the effect of auxiliary cleaning. In order to avoid turbidity caused by excessive fineness, the degree of carbonization of sophora flower charcoal extract is controlled to be 300-400 DEG C in the present application. Bicyclohexyl alcohol can gently relieve pain and inflammation, so natural extraction sources such as chrysanthemum plants are selected. Potassium cocoyl glycinate gently cleanses without damaging the barrier, and the amount of foam is moderate to avoid anal perianal residual stickiness.

[0025] The content of chlorogenic acid in honeysuckle extract is greater than or equal to 5%, which can effectively inhibit bacteria such as escherichia coli and staphylococcus aureus. The content of rosmarinic acid in rosemary extract is greater than or equal to 10%, which is used to inhibit fungi such as candida, and can replace chemical preservatives, and has no antagonism with honeysuckle and can enhance the antibacterial spectrum.

[0026] Since ceramide NP can repair the anal perianal mucosa lipid barrier, D-panthenol has the effects of moisturizing and promoting mucosa cell regeneration, ceramide NP and D-panthenol are added synergistically in the present application, which can improve the penetration effect, and D-panthenol is selected from food-grade raw materials, which is safer.

[0027] In order to match the anal perianal skin, the pH needs to be adjusted to 5.5-6.5, in which citric acid is used for pH adjustment to avoid sudden pH drop, and sodium citrate is used for pH buffering and formula stabilization. Through experiments, it is found that the best effect is obtained when the ratio of sodium citrate to citric acid is 1:1.2-1:1.5.

[0028] In the present embodiment, natural active ingredients with anti-inflammatory, hemostatic, and repairing effects are preferentially selected for the pain, bleeding, itching, and nevus prolapse caused by hemorrhoids; natural plant extract is used to replace chemical preservatives for antibacterial and preservative-free; and skin barrier components are supplemented for low irritation and mucosa protection, avoiding alcohol, strong acid and strong base, and irritating surface active substances. Through the complementary effects of the components, such as hemostatic components and repairing components, the components that are not conducive to the recovery of hemorrhoids, such as musk, ox gall, and irritating menthol, are avoided in the prior art, and components such as total asiaticoside and sophora flower charcoal extract are selected, which are rarely used and multifunctional, to form a unique formula.

[0029] Embodiment 2 A wet tissue liquid for improving hemorrhoid symptoms, comprising, in terms of mass percentage: Total asiaticoside 0.3 parts Sophora flower charcoal extract 0.5 parts Guggul alcohol 0.1 part Honeysuckle extract 0.4 parts Rosemary extract 0.2 parts Ceramide NP 0.05 parts D-panthenol 1.0 part Potassium cocoyl glycinate 1.5 parts Citric acid 0.02 parts Sodium citrate 0.03 parts Purified water 95 parts.

[0030] In this embodiment, the purified water in the formula is set to 95 parts, which can ensure that each component is uniformly dispersed without impurities and irritation, and is compatible with all active ingredients without the risk of precipitation.

[0031] Since the wet wipe liquid is usually alkaline, with a pH value of 7.0-8.0, while the perianal skin is weakly acidic with a pH of 5.5-6.5, and the alkaline environment easily damages the mucosal barrier. In the formula of the present application, we add citric acid and sodium citrate to buffer and stabilize the pH at the optimal value of 6.0, which can match the perianal physiological environment. To adjust the pH value of the formula, we select citric acid 0.02 parts, which can accurately stabilize the pH at about 6.0, and the test shows that the incidence of irritation reaction is ≤3%. In this formula, the addition of sodium citrate is 0.03 parts, and the ratio of sodium citrate to citric acid is 1:1.5, which has the best buffering effect, and at the same time avoids the pH fluctuation during storage.

[0032] Since the total glycoside of Centella asiatica meets the standard of anti-inflammatory repair effect at 0.3 parts, and there is no additional gain when it is higher than 0.5 parts, the cost is reduced, therefore, in this embodiment, we select to use 0.3 parts of total glycoside of Centella asiatica, and the test shows that the swelling reduction rate of hemorrhoids is ≥30% after continuous use for 14 days, which can produce good effect on hemorrhoids patients.

[0033] Sophora flower charcoal extract 0.5 parts can make the balance hemostatic speed effective in 5-8 minutes, and the perianal cleanliness is improved by 40% without residue. The addition of 0.1 part of guggul alcohol can make the analgesic effect ≥80%, and higher than 0.2 parts can easily cause burning sensation in a few people, therefore, in the optimized formula of this embodiment, the content of guggul alcohol is determined as 0.1 part, which can make the incidence of pain in users ≤5%, which is much lower than the 30% of menthol.

[0034] The prior art mostly uses chemical preservatives such as phenoxyethanol or a single natural bacteriostatic agent such as tea tree oil. However, phenoxyethanol has a mucous membrane toxicity risk, and tea tree oil has a narrow bacteriostatic spectrum and is only effective against bacteria, not fungi. However, the chlorogenic acid in the honeysuckle extract provided in the present application can be effective against bacteria, and the salvia acid in the rosemary extract can be effective against fungi. The addition of both can cover more than 90% of pathogenic bacteria around the anus, such as Escherichia coli, Staphylococcus aureus, and Candida albicans. At the same time, the antioxidant properties of rosemary can inhibit the oxidation of active ingredients, replacing the function of preservatives. Therefore, in the present formulation, we select honeysuckle extract 0.4 parts to enhance the bacterial inhibition rate to ≥99%, and rosemary extract 0.2 parts to enhance the fungal inhibition effect, while delaying the oxidation of active ingredients to extend the shelf life of the formulation to 12 months. It can cover most pathogenic bacteria while avoiding the risk of chemical preservatives.

[0035] The perianal skin mucosa of patients is repeatedly irritated by hemorrhoids, and the lipid barrier is easily damaged. The existing formula ignores barrier repair for dry and sensitive skin.

[0036] Ceramide NP at 0.05 parts can supplement the lipid barrier. After 28 days of continuous use by patients, the mucosal barrier recovery rate is ≥60% through testing, D-panthenol is less than 0.5 parts for insufficient moisturizing, and 1.0 parts can achieve moisturizing without stickiness. The perianal skin moisture content is increased by 25%. Potassium cocoyl glycinate at 1.5 parts has a cleaning power of ≥95% and a degreasing rate of only 1 / 10 of SLS, with a skin barrier damage rate of ≤8%. The ceramide NP added in the present application can supplement the mucosal lipid, D-panthenol can penetrate into the deep layer of the mucosa, promote cell regeneration, and provide protection to the barrier, making it suitable for long-term use by hemorrhoid patients.

[0037] Therefore, the present embodiment has a high pain and itching relief rate for hemorrhoid patients, a high bleeding stop rate, a reduced frequency of hemorrhoid prolapse after 28 days of use, safe bacteriostatic properties without preservatives, a low incidence of mucosal irritation, a cleaning power that meets the standards, no stinging or dryness, a product pH that can adapt to the perianal environment, and a significantly improved comfort level. The mucosal repair rate is high, and the incidence of disease deterioration is low, making it suitable for long-term care use.

[0038] Example 3 Based on the wet wipes described in Examples 1-2 above for improving hemorrhoid symptoms, we made a kind of toilet cleaning wet wipes.

[0039] In the preparation process, in order to realize high softness and avoid friction irritation, a spunlace non-woven fabric with cotton content ≥50% and standard of 80g / m² is selected as the carrier in the implementation process, and 1 part of the wet wipe liquid:3 parts of the non-woven fabric weight ratio is used to uniformly spray the liquid on the non-woven fabric. The spraying mode adopts multi-nozzle spraying, which avoids local over-wetting or over-drying. Then, an aluminum-plastic composite film is used for sealing and packaging, which effectively blocks oxygen and moisture, and can prolong the shelf life. After preparation, because the chrysanthemum extract is easy to oxidize under light, in order to not affect the preservation effect, the above wet wipe is sealed and stored in the dark.

[0040] Example 4 An application of a wet wipe liquid for improving hemorrhoid symptoms, comprising the wet wipe liquid for improving hemorrhoid symptoms, the wet wipe liquid for improving hemorrhoid symptoms is applied to a sanitary product for improving hemorrhoid symptoms. The sanitary product includes but is not limited to wet wipes, wet paper, sanitary wipes, sanitary paper, toilet wet wipes, toilet wet paper, antibacterial lotion, bacteriostatic lotion, cotton swab and the like.

[0041] Example 5 An application of a wet wipe liquid for improving hemorrhoid symptoms, comprising the wet wipe liquid for improving hemorrhoid symptoms, the wet wipe liquid for improving hemorrhoid symptoms is applied to a sanitary product for improving hemorrhoid symptoms. The sanitary product includes but is not limited to wet wipes, wet paper, sanitary wipes, sanitary paper, toilet wet wipes, toilet wet paper, antibacterial lotion, bacteriostatic lotion, cotton swab and the like.

[0042] Example 6 This embodiment is directed to a wet wipe liquid for improving hemorrhoid symptoms used in the above examples 1-5, in the preparation process, the following operation steps are included: I: preparation stage.

[0043] We use reverse osmosis equipment to treat purified water to ensure that the electrical conductivity is ≤10μS / cm, and after boiling, it is cooled to 40~45℃ for standby, which not only helps to dissolve the difficultly soluble ingredients, but also avoids the destruction of active ingredients by high temperature.

[0044] Preparation of Sophora japonica charcoal extract: (1) In order to avoid turbidity of the subsequent liquid and foreign matter remaining on the wet wipe, the Sophora japonica charcoal is sieved through a 100 mesh sieve to remove coarse particles, and dispersed into a paste with 5 times the weight of preheated purified water.

[0045] (2) Ultrasonic treatment is adopted for 5 minutes at a frequency of 40kHz to promote the full expansion of the porous structure and improve the hemostatic and adsorption efficiency.

[0046] Preparation of ceramide NP: Since ceramide NP is a lipid component, D-panthenol is used to assist dissolution to avoid direct addition of water to form lumps.

[0047] Mix the ceramide NP in the amount of the formula with 0.2 parts of D-panthenol reserved in advance from the total formula amount.

[0048] (3) Add 2 times by weight of preheated purified water, and stir until a transparent dispersion liquid is formed.

[0049] II. Preparation stage.

[0050] Stage 1: Preparation of water phase base. First, add 90% of the pre-processed purified water to the stirring tank, and the remaining 10% is used for subsequent weight compensation. Start low-speed stirring to avoid excessive foam. The low-speed stirring speed is 150 r / min; Secondly, slowly add the formula amount of potassium cocoyl glycinate, and stir for 3 minutes until completely transparent. This step needs to be stirred until there is no particle feeling to ensure uniform cleaning power. Thirdly, since D-panthenol is easily soluble in water, it is preferred to add the remaining D-panthenol to build a moisturizing base in advance. Therefore, add the remaining 0.8 parts of D-panthenol, which is 1.0 parts of the total formula amount minus the reserved 0.2 parts. Stir at a medium speed of 300 r / min for 2 minutes until uniform. Stage 2: Active ingredient dispersion. (1) Keep the stirring tank temperature at 40~45℃, add the pre-processed Sophora flower charcoal extract paste, and stir at medium speed for 5 minutes. At the same time, start ultrasonic dispersion, the stirring speed is 350 r / min, the ultrasonic frequency is 30 kHz, 30 seconds each time, interval 1 minute, a total of 3 times, to ensure that the charcoal particles are uniformly suspended without sedimentation, avoiding uneven local hemostasis effect; (2) Add total glycosides of Centella asiatica, honeysuckle extract, and rosemary extract one by one. Stir for 2 minutes after adding each ingredient until completely dissolved. Since total glycosides of Centella asiatica is a water-soluble powder, it needs to be added slowly to avoid clumping. (3) Add the pre-processed ceramide NP dispersion, stir at a speed of 200 r / min for 3 minutes to ensure uniform dispersion of the lipid component and avoid local mucosa irritation or skin sticky feeling. Stage 3: Addition of mild analgesic ingredients. Since myrrh alcohol is sensitive to high temperatures and degrades above 50℃, and myrrh alcohol is slightly soluble in water, it needs to be stirred thoroughly at low temperature to avoid stratification and affect the analgesic effect. Therefore, reduce the stirring tank temperature to 30~35℃, add the formula amount of myrrh alcohol, and stir at a speed of 180 r / min for 5 minutes until no oil flowers appear. Stage 4: pH adjustment to adapt to the perianal physiological environment. (1) Dilute the formula amount of citric acid with 5 times purified water to avoid sudden local pH drop caused by direct acid addition. Slowly add the citric acid solution with a dropper, and monitor the pH with a pH meter while adding. Adjust the pH to 5.8~6.2; (2) Add the formula amount of sodium citrate, stir at 250 r / min for 3 minutes, detect the pH again, if it deviates from the target range, fine-tune with dilute citric acid or sodium citrate solution, and finally stabilize the pH to 6.0±0.1; (3) In order to make up for the water volatilized in the preparation process, add the remaining 10% purified water, stir at 300 r / min for 5 minutes, and make the total weight reach the standard. Stage 5: Filtration. Stop stirring and use negative pressure filtration, control the flow rate at 100 mL / min, filter the liquid through a 0.45 μm water filter membrane to avoid damage to the filter membrane caused by excessive pressure, and collect the filtrate. This step can remove undissolved small particles to avoid friction of the anal mucosa during use of the wet wipes. After completion, we took 10 mL of the filtrate for immediate inspection and drew the following conclusions: (1) The appearance is clear and transparent, without precipitate, stratification or foreign matter; (2) pH: 6.0±0.1; (3) Bacteriostatic pretest, take 2 mL of the filtrate, add it to the culture medium containing E. coli, incubate at 37°C for 24 hours, and preliminarily verify the bacteriostatic effect. Observe the diameter of the bacteriostatic circle to be ≥8 mm; (4) Transfer the qualified filtrate to a sterile storage tank, seal it and place it at 25°C in the shade for 24 hours for stability observation. If there is no stratification or precipitation, it is qualified.

[0051] In order to further illustrate the advantages of the present patent, we set up 3 groups of comparative examples for function comparison, among which the optimal formula is the formula in Example 2.

[0052] Comparative Example 1 In order to verify the safety and bacteriostatic stability of the natural bacteriostatic ingredient "preservative-free" added, which has advantages over the formula with chemical preservatives, we designed Comparative Example 1, and the specific ingredient composition is shown in Table 1.

[0053] .

[0054] Since chlorogenic acid is effective against gram-negative bacteria and salvia acid has antifungal and antioxidant effects, the two can synergistically cover 90% of pathogenic bacteria around the anus, such as E. coli, Staphylococcus aureus and Candida albicans. Therefore, honeysuckle extract 0.4 parts, with chlorogenic acid ≥5%, and rosemary extract 0.2 parts, with salvia acid ≥10%.

[0055] The invention realizes non-preservation, low irritation, and optimal normal temperature stability, and meets the compliance requirements of the European Union EC1223 / 2009 on natural preservative systems, avoids the use restrictions of phenoxyethanol in the mucosa damaged population, and the comparative group 1 needs to be labeled "cautious use" in such population. The formula provided by the invention not only solves the mucosa irritation problem of chemical preservatives, but also realizes the bacteriostatic stability comparable to chemical preservatives, and fills the technical blank of non-preservation and long-acting bacteriostasis.

[0056] Comparative example 2 This control experiment is to verify the mild analgesic and mucosa repair effect of the invention. In the control group 2, menthol is used to replace commiphora molmol, and ceramide NP is removed. The specific ingredient composition is shown in Table 2.

[0057] .

[0058] Menthol is the mainstream analgesic ingredient in traditional hemorrhoid products, but the activation rate of broken mucosa TRPV1 receptor is as high as 80%, and it has no repair function. The activation rate of broken mucosa TRPV1 receptor by commiphora molmol is only 15%, and at the same time, the analgesic activity IC50 of commiphora molmol is close to that of menthol (IC50 = 20 μmol / L), but the stimulating TRPV1 receptor activation rate is only 1 / 5 of that of menthol.

[0059] In the mucosa barrier repair comparison, the 48-hour TEER value recovery rate of the invention is 62% ± 3% (normal mucosa TEER value = 1500 Ω·cm²), but the 48-hour TEER value recovery rate of the control group 2 is only 28%.

[0060] Therefore, ceramide NP can supplement mucosa lipids in an inflammatory environment, and cooperates with D-panthenol to repair. The formula of the invention inhibits inflammation through analgesic and repair double paths, avoiding the disease recurrence caused by analgesic but not anti-inflammatory in the comparative group 2.

[0061] Comparative example 3 This control experiment is to verify the hemostatic and cleaning effect. In this comparative example, we use fresh sophora flower extract to replace the sophora flower charcoal extract in the invention. The specific ingredient composition is shown in Table 3.

[0062] .

[0063] Fresh sophora flower is a traditional hemostatic ingredient. Sophoraflavescens glycoside promotes thrombin activation to stop bleeding, but has no porous structure and needs to add additional cleaning ingredients such as SLS. In the comparative group 3, the content of fresh sophora flower extract is 0.5 parts, and the content of sophoraflavescens glycoside is ≥5%.

[0064] The invention is a flos sophorae carbon extract, wherein flos sophorae is carbonized at 350 DEG C for 2 hours, the flos sophorae glycoside content is greater than or equal to 3%, the carbonized flos sophorae has a porous structure with a pore size of 2-5 nm, the adsorption property is improved, and the retention rate of the hemostatic active ingredient flos sophorae glycoside is 85%.

[0065] In a rabbit ear artery bleeding model test, New Zealand white rabbits were selected, set as n=10 / group, and the sample was used after 0.5 mL of bleeding, and the hemostatic time and prothrombin time were recorded: we found that the hemostatic time of the invention was 6 minutes, and the prothrombin time was shortened by 28%, while the hemostatic time of the comparative group 3 was 17 minutes, and the prothrombin time was only shortened by 15%.

[0066] In the cleanliness test, we used pigskin to simulate perianal skin and applied artificial dirt: 5% fecal residue, 3% mucus, and 2% sebum. After wiping with the product of the comparative experiment group, the residual amount was measured by spectrophotometer.

[0067] We obtained: the absorbance of the invention is 0.08±0.01, and the removal rate is 96%; the absorbance of the comparative group 3 is 0.35±0.02, and the removal rate is 68%.

[0068] Therefore, the flos sophorae carbon has good cleaning and hemostatic effect in physical adsorption and chemical hemostasis after being synergized with other formulations, avoiding the irritation of additional SLS to the mucous membrane in the comparative group 3. At the same time, the carbonized structure protects flos sophorae glycoside from oxidation, solving the storage drawbacks of the flos sophorae extract, such as easy degradation, need for light-protected cold storage.

[0069] Therefore, as described above, the wet wipe solution for improving hemorrhoid symptoms, wet wipes, production method and application provided by the invention have the following beneficial effects: (1) The pain and itching relief rate after use is greater than or equal to 80%, the bleeding stop rate is greater than or equal to 90%, and the frequency of hemorrhoid prolapse is reduced by 50% after 28 days of use; (2) The bacteriostatic rate is greater than or equal to 99%, there is no preservative, the shelf life is 12 months, and the incidence of mucous membrane irritation is less than or equal to 5%; (3) The cleaning power meets the standard, there is no stinging and dry feeling, the pH is adapted to the perianal environment, and the comfort is significantly improved; (4) The mucous membrane repair rate after use is greater than or equal to 60%, the incidence of disease worsening is reduced by 50%, and it is suitable for long-term care use.

[0070] Finally, it should be noted that the above description is only a preferred embodiment of the invention and is not intended to limit the invention. Although the invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent replacements of some technical features, as long as they are within the spirit and principles of the invention. Any modification, equivalent replacement, improvement, etc. made within the scope of the invention shall be included in the protection scope of the invention.

Claims

1. A wet wipe solution for improving hemorrhoid symptoms, characterized in that, Calculated as a percentage by mass, including: Total glycosides from Centella asiatica 0.1-0.5 parts Sophora japonica charcoal extract 0.3~0.8 parts Bisabolol 0.05~0.2 parts Honeysuckle extract 0.2~0.6 parts Rosemary extract 0.1~0.4 parts Ceramide NP 0.03~0.1 parts D-Panthenol 0.5~1.5 parts Potassium cocoyl glycinate 1.0~2.0 parts Citric acid 0.01~0.03 parts Sodium citrate 0.02~0.05 parts The remaining amount of purified water.

2. The wet wipe solution for improving hemorrhoid symptoms according to claim 1, characterized in that, Calculated as a percentage by mass, including: Centella asiatica total glycosides 0.3 parts 0.5 parts of Sophora japonica charcoal extract Bisabolol 0.1 parts Honeysuckle extract 0.4 parts 0.2 parts rosemary extract Ceramide NP 0.05 parts D-Panthenol 1.0 part 1.5 parts of potassium cocoyl glycinate Citric acid 0.02 parts Sodium citrate 0.03 parts 95 parts purified water.

3. The wet wipe solution for improving hemorrhoid symptoms according to claim 1, characterized in that, The honeysuckle extract contains ≥5% chlorogenic acid.

4. The wet wipe solution for improving hemorrhoid symptoms according to claim 1, characterized in that, The rosemary extract contains ≥10% carrageenan.

5. A method for preparing a wet wipe solution for improving hemorrhoid symptoms, used to prepare the wet wipe solution for improving hemorrhoid symptoms as described in any one of claims 1-4, characterized in that, The following steps are included: S1: Preprocessing stage: (1) The purified water is treated with reverse osmosis equipment to ensure that the conductivity is ≤10μS / cm, and then cooled to 40-45℃ after boiling for later use; (2) Remove coarse particles from the Sophora japonica charcoal extract and disperse it into a paste with 5 times its weight of preheated purified water; (3) Mix ceramide NP with D-panthenol, add 2 times the weight of preheated purified water, and stir until a transparent dispersion is formed; S2: Preparation stage: SS1: Add pretreated purified water to the mixing tank and stir at a speed of 150 r / min; add the prescribed amount of potassium cocoyl glycinate and stir for 3 minutes until completely transparent; Add D-panthenol and set the stirring speed to 300 r / min for 2 minutes until homogeneous. SS2: Keep the temperature of the mixing tank at 40-45℃, add the pretreated Sophora japonica charcoal extract paste, set the speed to 350r / min and stir for 5 minutes, while turning on ultrasonic dispersion to ensure that the charcoal particles are evenly suspended; Add the total glycosides of Centella asiatica, honeysuckle extract and rosemary extract in sequence. After each ingredient is added, set the speed to 300r / min and stir until completely dissolved. Add the pretreated ceramide NP dispersion and stir at 200 r / min until uniformly dispersed; SS3: Reduce the temperature of the mixing tank to 30~35℃, add bisabolol, and stir at 180 r / min until no oil droplets appear; SS4: Slowly add citric acid solution dropwise with a dropper, monitoring the pH with a pH meter while adding, and adjust the pH to 5.8~6.2; add the prescribed amount of sodium citrate, stir at 250 r / min for 3 minutes, and simultaneously check the pH to 6.0±0.1; Add purified water and stir at 300 rpm. S3: Filtration stage: Stop stirring, filter the liquid through a 0.45μm aqueous filter membrane and collect the filtrate.

6. A wet wipe for improving hemorrhoid symptoms, comprising the wet wipe liquid for improving hemorrhoid symptoms as described in any one of claims 1-4, characterized in that, The wipes also contain spunlace nonwoven fabric, on which the wipe liquid for improving hemorrhoid symptoms is loaded.

7. The wet wipes for improving hemorrhoid symptoms according to claim 6, characterized in that, The ratio of wet wipe liquid to spunlace nonwoven fabric is 1:3 based on mass percentage.

8. The application of a wet wipe solution for improving hemorrhoid symptoms, comprising the wet wipe solution for improving hemorrhoid symptoms as described in any one of claims 1-4, characterized in that, The aforementioned wet wipe liquid for improving hemorrhoid symptoms is a hygiene product used to improve hemorrhoid symptoms.

9. The application of a wet wipe liquid for improving hemorrhoid symptoms, comprising the wet wipe for improving hemorrhoid symptoms as described in claim 7, characterized in that, The wipes described above are hygiene products used to improve hemorrhoid symptoms.