Two-phase mixed fat-reducing shaping cream as well as preparation method and application thereof

Abstract

The invention relates to a two-phase mixed fat-reducing and shaping cream as well as a preparation method and application thereof. The fat-reducing and shaping cream comprises an oil phase and a water phase, wherein the oil phase is prepared from the following raw materials: natural vegetable fat, plant essential oil, isohexadecane, caprylic / capric triglyceride, cinnamon oil, blumea oil, tocopherol, bisabolol and pentaerythritol tetra (bis-tert-butylhydroxyhydrocinnamate) ester; the water phase is prepared from the following raw materials: pentahydroxy flavone, a compound of a paraguay tea leaf extract and a caffeine / caffeine palmityl carnitine compound, a glaucine and coco-glucoside compound, a calanthe extract and gluconolactone compound, p-hydroxyacetophenone, a pH regulator, a thickening agent, an emulsifier, a humectant, an emollient and water. The fat-reducing and shaping cream is high in safety, has remarkable fat-reducing and tightening effects after being continuously smeared and massaged for 2 weeks, and can be used by people with daily obesity, muscle relaxation and the like.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a two-phase mixed fat-reducing and shaping cream, its preparation method, and its application. Background Technology

[0002] In recent years, due to the rapid improvement of people's living standards, the number of obese people has gradually increased. Obesity is a metabolic disease caused by a long-term imbalance between the body's energy intake and utilization. The surplus energy is stored as fat, thus causing obesity. The process of fat formation includes fatty acid intake, fatty acid synthesis, and fatty acid storage. To solve the problem of obesity, people have been searching for effective fat reduction methods, such as injections, liposuction, meal replacement products, and topical products. Among these, injections and liposuction often have disadvantages such as requiring a recovery period, easy rebound, and high risks. While meal replacement products can play a good auxiliary role, they have problems such as poor taste, poor nutrition, and potential impact on mood. Topical slimming and shaping products can effectively address these issues, and related research has been increasing in recent years. Chinese patent CN117045574 A discloses a slimming emulsion that promotes the browning of fat cells and its preparation, comprising the following ingredients: 20-50 parts camel milk extract, 10-30 parts Isochrysis galbana extract, 10-30 parts St. John's wort extract, 2-6 parts tocopherol, 0.1-5 parts allantoin, 5-25 parts emulsifier, 5-20 parts moisturizer, 10-30 parts skin conditioning agent, 1-5 parts thickening and stabilizing agent, 0.01-1 part preservative, and 1-50 parts water. This invention achieves its slimming and fat-reducing effects by promoting the browning of white adipose tissue into brown adipose tissue and reducing the accumulation of fat droplets in adipose tissue. Chinese patent CN 116585444 A discloses a method for preparing a fat-reducing cream, comprising the following raw materials: 10-20 parts of roselle extract, 5-10 parts of five-finger peach, 10-20 parts of yellow water lily, 10-20 parts of concentrated extract of traditional Chinese medicine, 10-20 parts of smilax glabra, 5-15 parts of rhubarb, 1-2 parts of ginger oil, 1-2 parts of black pepper essential oil, 5-10 parts of sweet almond oil, 1-2 parts of stearyl alcohol, 3-6 parts of stearic acid, 0.2-0.8 parts of phenoxyethanol, 1.5-2.5 parts of emulsifier, 0.2-0.8 parts of emulsion stabilizer, 10-20 parts of polyol, 0.2-0.8 parts of inorganic salt, 0.2-0.8 parts of preservative, 20-30 parts of water, and 10-20 parts of petrolatum. While the slimming patch provided by this invention can target weight loss and fat reduction, its mechanism of action is unclear, and its effectiveness is relatively poor. Furthermore, long-term use of the patch can compromise skin sensitivity. It can be seen that existing technologies for topical slimming and body shaping products either have unclear mechanisms or rely on a single mechanism, failing to comprehensively consider the various factors influencing obesity, such as cellular lipid uptake, inflammation of fat cells, and mitochondrial activity. Therefore, they have failed to achieve significant slimming and body shaping effects. Summary of the Invention

[0003] To address the shortcomings of existing technologies, this invention provides a two-phase mixed fat-reducing and shaping cream, its preparation method, and its application. The two-phase mixed fat-reducing and shaping cream prepared by this invention has no serious adverse reactions on the skin, has good safety, and can significantly reduce the weight of volunteers, reduce fat thickness, and improve skin elasticity, thus achieving a significant fat-reducing and shaping effect. It can be used by people with obesity, muscle relaxation, etc.

[0004] In a first aspect, the present invention provides a two-phase mixed fat-reducing and shaping cream comprising two phases, namely an oil phase and an aqueous phase, wherein the oil phase and the aqueous phase are mixed in a volume ratio of 1:0.5 to 5, preferably 1:2.

[0005] (1) The composition of the oil phase is as follows:

[0006] The oil phase comprises the following raw materials by weight percentage: 40-70% natural vegetable oil, 5-20% vegetable essential oil, 10-30% isohexadecane, 5-15% caprylic / capric triglyceride, 1-5% cinnamon oil, 1-5% Artemisia argyi oil, 0.1-1% tocopherol, 0.1-1% bisabolol, and 0.1-1% pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester;

[0007] Furthermore, the natural plant oil in the oil phase is selected from one or more of sweet almond oil, baobab seed oil, pomegranate seed oil, burr walnut seed oil, and evening primrose oil;

[0008] Furthermore, the weight ratio of the natural plant oils in the oil phase, namely sweet almond oil, baobab seed oil, pomegranate seed oil, burdock seed oil, and evening primrose oil, is (15-25):(2-6):(10-20):(15-25):(1-5).

[0009] Furthermore, the plant essential oils in the oil phase are selected from two to four of the following: laurel leaf oil, saffron oil, gardenia oil, and bitter orange blossom oil, and are also compounded with two to five of the following: ginger root oil, benzoin resin extract, angelica extract, chuanxiong oil, and thyme oil.

[0010] Preferably, the weight ratio of laurel leaf oil, saffron oil, ginger root oil, and benzoin resin extract in the plant essential oil is (0.1-1):(1-5):(1-5):(1-5);

[0011] More preferably, the weight ratio of laurel leaf oil, saffron oil, gardenia oil, and bitter orange blossom oil in the plant essential oil is (0.1-1):(1-5):(0.1-1):(0.1-1), and the weight ratio of ginger root oil, benzoin resin extract, angelica extract, chuanxiong oil, and thyme oil is (1-5):(1-5):(0.1-2):(0.1-5):(0.1-1).

[0012] (2) The aqueous phase composition is as follows:

[0013] The aqueous phase comprises the following raw materials by weight percentage: 0.01–0.2% quinacrine, 0.5–3% Paraguayan tea leaf extract and small-fruit coffee leaf / seed extract complex, 0.5–3% caffeine and palmitoylcarnitine complex, 0.5–2.5% papaverine and cocoyl glucoside complex, 0.5–2% *Cymbidium goeringii* extract and gluconolactone complex, 0.3–1% p-hydroxyacetophenone, 0.01–0.5% pH adjuster, 0.4–1.5% thickener, 1–5% emulsifier, 5–20% humectant, 5–25% emollient, and 50–80% water.

[0014] Furthermore, the pH of the aqueous phase is 5.5 to 6.5, and the regulator is triethanolamine, wherein the weight percentage of triethanolamine is 0.1% to 0.5%.

[0015] Furthermore, the thickener in the aqueous phase is selected from one or more of xanthan gum, ammonium acryloyl dimethyl taurate / VP copolymer, and acrylate / C10-30 alkanol acrylate crosslinking polymer;

[0016] Preferably, the weight ratio of xanthan gum, ammonium acryloyl dimethyl taurate / VP copolymer, and acrylate / C10-30 alkanol acrylate crosslinking polymer in the thickener in the aqueous phase is (0.05-0.2):(0.3-1):(0.1-0.5).

[0017] Furthermore, the emulsifier in the aqueous phase is selected from one or more of PEG-20 methyl glucose sesquistearate, methyl glucose sesquistearate, and MONTANOV 202;

[0018] Preferably, the weight ratio of PEG-20 methyl glucosesquistearate, methyl glucosesquistearate, and MONTANOV 202 in the emulsifier is (0.5-3):(0.2-1):(0.5-1).

[0019] Furthermore, the humectant in the aqueous phase is selected from one or more of glycerin, 1,3-butanediol, 1,2-hexanediol, 1,3-propanediol, and sodium hyaluronate;

[0020] Preferably, the weight ratio of glycerin, 1,3-butanediol, 1,2-hexanediol, 1,3-propanediol, and sodium hyaluronate in the humectant in the aqueous phase is (2-10):(2-8):(0.5-1):(0.5-1):(0.05-0.2).

[0021] Furthermore, the emollient is selected from one or more of the following: triethylhexanoate, isononyl isononanoate, shea butter, coconut oil-caprylate / capric acid ester, and Atlantic sea bream oil;

[0022] Preferably, the weight ratio of triglyceride (ethylhexanoate), isononyl isononanoate, shea butter, coconut oil-caprylate / capric acid ester, and Atlantic sea bream oil in the emollient in the aqueous phase is (2-6):(2-6):(1-5):(2-6):(0.5-2).

[0023] Secondly, the present invention provides a method for preparing the aforementioned two-phase mixed fat-reducing and shaping cream, comprising the following steps:

[0024] (1) Preparation of the oil phase

[0025] Weigh each raw material according to the formula and divide it into phase A, phase B and phase C for later use; the raw material of phase A includes pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester and caprylic / capric triglyceride; the raw material of phase B includes natural plant oil and isohexadecane; the raw material of phase C includes cinnamon oil, artemisia oil, tocopherol, bisabolol and plant essential oil.

[0026] S11: Add pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester and caprylic / capric triglyceride A phase raw materials into a homogenizing emulsifying pot, heat to 70-75℃, and stir to dissolve;

[0027] S12: Cool down to 50-60℃, add the B phase raw material into the homogenizing emulsifier in sequence, and stir to disperse evenly;

[0028] S13: Cool to 40-45℃, add C phase raw material sequentially, homogenize at 1000-1500 r / min for 3-5 min, cool to below 30℃ and discharge to obtain oil phase;

[0029] (2) Preparation of the aqueous phase

[0030] Weigh each raw material according to the formula and divide it into phases A, B, C, and D for later use. Phase A includes water, thickener, humectant, and p-hydroxyacetophenone. Phase B includes emulsifier and moisturizer. Phase C includes pH adjuster. Phase D includes 5-hydroxyflavone, Paraguayan tea extract and small-fruit coffee leaf / seed extract complex, caffeine and palmitoylcarnitine complex, papaverine and cocoyl glucoside complex, and spatholobus suberectus extract and gluconolactone complex.

[0031] S21: Add the A phase raw material into the homogenizing emulsifying pot, heat to 70-75℃, and homogenize at 3000-3500r / min for 3-5min while stirring to dissolve;

[0032] S22: Add the B phase raw material into the oil phase pot of the homogenizing emulsifier, heat to 80-85℃, and stir to disperse evenly;

[0033] S23: Mix phase A and phase B raw materials, homogenize at 3000-4000 r / min at 70-80℃ for 5-10 min, and then keep warm at 80-85℃ for 15-20 min;

[0034] S24: Stir and cool to 50-55℃, then add C phase raw material and homogenize at 3000-4000 r / min for 1-2 min;

[0035] S25: Stir and cool to 40-45℃, then add D phase raw material, homogenize at 1000-1500r / min for 3-5min, cool to below 30℃ and discharge to obtain aqueous phase.

[0036] Thirdly, the present invention provides a method for using a two-phase mixed fat-reducing and shaping cream, wherein the oil phase and the water phase are mixed in a volume ratio of 1:0.5 to 5, preferably 1:2.

[0037] This invention provides a two-phase slimming and shaping cream, comprising an oil phase and an aqueous phase. The oil phase is a brown, transparent essential oil, and the aqueous phase is a pale yellow cream. The oil phase is primarily composed of natural plant oils rich in skin-beneficial substances and possessing skin-strengthening and revitalizing effects, such as pomegranate seed oil and burdock seed oil, as well as plant essential oils with very small molecules that alleviate inflammation in fat cells and reduce interstitial moisture. Among the selected plant essential oils, laurel leaf oil and saffron oil treat skin inflammation; bitter orange blossom oil and gardenia oil soothe and heal, promote cell regeneration, and soften and refine the skin; ginger root oil and angelica extract invigorate blood circulation, relieve pain, and treat wounds; chuanxiong oil and thyme oil invigorate blood circulation, promote qi flow, and dispel wind; and benzoin resin extract invigorates blood circulation and increases skin elasticity. This essential oil phase has anti-inflammatory and anti-edema effects and also possesses strong permeability. When mixed with the pale yellow cream phase, it enhances the absorption of its active ingredients and strengthens its efficacy.

[0038] The various active ingredients selected in the aqueous phase complement each other in mechanism, targeting each stage of adipocytes in the skin, and working together to achieve the effect of fat reduction and firming. (1) The complex of Paraguayan tea extract and small-fruit coffee leaf / seed extract contains a large amount of cafestol and coffee bean alcohol, which reduces the storage effect of adipocytes on triglycerides transported in the blood by inhibiting the expression of lipid receptor factors LDL and VLDL on the adipocyte membrane, thereby inhibiting the enlargement of normal adipocytes; (2) Calcium ions in adipocytes inhibit the secretion of adenylate cyclase in preadipocytes, reduce AMPc, and promote the differentiation of adipocytes. The complex of papaverine and cocoyl glucoside is a superoxide that inhibits calcium flow in adipocytes, thereby effectively inhibiting their differentiation. It also inhibits the expression of elastase and matrix metalloproteinase MMP9, relieves inflammation in adipocytes, promotes the reversal of adipose tissue into fibrous tissue, and enhances the connection between the dermis and epidermis, making the collagen network denser. (3) Five-hydroxyflavone is a flavonoid that can improve mitochondrial activity and effectively promote the decomposition of fat deposits into glycerol and fatty acids. (4) The complex of caffeine and palmitoyl carnitine can promote microcirculation and reduce interstitial water, while palmitoyl carnitine can enhance the transport of fatty acids, transporting the fatty acids decomposed by caffeine and five-hydroxyflavone to the mitochondria for complete combustion, enhancing mitochondrial activity, and increasing fat reduction. (5) The complex of shrimp spiny orchid extract and gluconolactone can activate the signal exchange between adipose stem cells and fibroblasts, activate the function and regeneration of fibroblasts, promote the synthesis of collagen and elastin, lift and tighten the skin contour, and lighten stretch marks.

[0039] Existing technologies are basically designed only to promote fat breakdown and reduce edema. This invention innovatively targets the entire process of adipocytes in the skin, forming a closed loop mechanism with complementary and synergistic effects: First, it eliminates inflammation in enlarged adipocytes and reduces lipid absorption by adipocytes, preventing further enlargement; at the same time, it improves the drainage function of adipocytes, eliminating edema; second, it inhibits calcium flow in adipocytes, thereby inhibiting adipocyte differentiation and preventing further increase in the number of adipocytes; third, it inhibits phosphodiesterase activity, promoting the breakdown of adipocytes into glycerol and fatty acids, while improving the transport of fatty acids and mitochondrial activity, enabling complete burning of fat deposits; finally, it protects and repairs the extracellular matrix, enhances the adhesion of the dermis, and promotes the synthesis of collagen and elastin on fibroblasts, resulting in firming and reduced wrinkles.

[0040] The various active components of this invention are formulated in specific proportions to achieve synergistic effects. The two phases, when mixed in a specific ratio, further enhance synergistic effects, strengthen penetration, promote absorption, and offer high safety and significant efficacy.

[0041] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0042] (1) Compared with existing fat reduction methods such as injection, liposuction, meal replacement products, and topical application products, the two-phase mixed fat reduction and shaping cream prepared in this invention is very safe and reliable, and has no rebound effect.

[0043] (2) The fat reduction and shaping mechanism of the two-phase mixed fat reduction and shaping cream prepared by the present invention is different from that of the prior art. By mixing each active component in a specific ratio, they work synergistically. By mixing the oil phase and water phase in a specific ratio, they can achieve better synergistic effects, enhance penetration, promote absorption, have high safety, and achieve a more comprehensive and targeted fat reduction and shaping effect.

[0044] (3) The two-phase mixed fat-reducing and shaping cream prepared by this invention can effectively improve skin firmness, significantly reduce weight, decrease fat thickness, and improve skin elasticity, thus achieving a significant fat-reducing and shaping effect. Whether tested by instruments or based on volunteers' own feelings, there is a significant improvement effect. Moreover, the two-phase mixed fat-reducing and shaping cream prepared by this invention has no serious adverse reactions on the skin, has good safety, and can be used by people with obesity, muscle relaxation, etc. Detailed Implementation

[0045] Experimental methods in the following embodiments of the present invention, unless otherwise specified, are generally performed under conventional conditions or as recommended by the manufacturer. All commonly used chemical reagents used in the embodiments are commercially available products. Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the invention.

[0046] The following embodiments further describe the present invention, but these embodiments are not intended to limit the scope of protection of the present invention.

[0047] Example 1: Preparation of a two-phase blended slimming and shaping cream

[0048] The composition of the oil and water phases in the two-phase blended slimming and shaping cream, by weight percentage (%), is shown in Tables 1 and 2:

[0049] Table 1: Formulation of Oil Phase

[0050]

[0051] Table 2: Formulation of Aqueous Phase

[0052]

[0053]

[0054]

[0055] The preparation process of the nine groups of two-phase mixed fat reduction and body shaping compositions in Example 1 above is as follows:

[0056] (1) Preparation of the oil phase

[0057] S11: Add the A phase raw material into a homogenizing emulsifier, heat to 70-75℃, and stir to dissolve;

[0058] S12: Cool down to 60℃, add the B phase raw material into the homogenizing emulsifying pot in sequence, and stir to disperse evenly;

[0059] S13: Cool down to 45℃, add C phase raw materials sequentially, homogenize at 1000~1500r / min for 3~5min, cool down to below 30℃ and discharge to obtain oil phase;

[0060] (2) Preparation of the aqueous phase

[0061] S21: Add the A phase raw material into the homogenizing emulsifying pot, heat to 70-75℃, and homogenize at 3000-3500r / min for 3-5min while stirring to dissolve;

[0062] S22: Add the B phase raw material into the oil phase pot of the homogenizing emulsifier, heat to 80-85℃, and stir to disperse evenly;

[0063] S23: Mix phase A and phase B raw materials, homogenize at 3000-4000 r / min at 70-80℃ for 5-10 min, and then keep warm at 80-85℃ for 15-20 min;

[0064] S24: Stir and cool to 55℃, then add C phase raw material and homogenize at 3000~4000r / min for 1~2min;

[0065] S25: Stir and cool to 45℃, then add D phase raw material, homogenize at 1000~1500r / min for 3~5min, cool to below 30℃ and discharge to obtain aqueous phase with pH 6.0±0.5;

[0066] In this embodiment, all nine groups of two-phase mixed slimming and shaping creams can be prepared within the above-mentioned preparation conditions. The two-phase mixed slimming and shaping cream is obtained by mixing the prepared oil phase and water phase at a volume ratio of 1:2.

[0067] Experimental Example 1: Safety Test of a Two-Phase Mixture Fat Reduction and Shaping Cream

[0068] The safety testing method for the nine groups of two-phase mixed slimming and shaping creams in Example 1 of this invention is as follows:

[0069] Test basis: Cosmetic Safety Technical Specifications 2015 Edition, Human Skin Patch Test, 24-hour closed patch test;

[0070] Experimental subjects: 30 healthy volunteers aged 20-59 years with no history of allergies were randomly selected;

[0071] Test procedure: Select an area not exceeding 50mm² 2 A suitable spot tester with a depth of approximately 1 mm was used. The two-phase product was mixed at a volume ratio of 1:2 (oil phase: brown transparent essential oil) and 1:2 (water phase: pale yellow cream). 0.020–0.025 mL of each of the nine groups of two-phase mixed slimming and shaping cream samples from Example 1 was weighed into the spot tester. After cleaning the subject's hands, the spot tester containing the mixed slimming and shaping cream sample was applied to the flexor side of the subject's forearm for 24 hours. The subject was advised to keep the patch area dry during these 24 hours and avoid strenuous exercise, scratching, and prolonged sun exposure. After 24 hours, the tester was removed and marked. After 30 minutes, once the indentation disappeared, the skin was assessed under sufficient light. The grading criteria for adverse skin reactions are shown in Table 3 below, and the results of adverse skin reactions to the two-phase mixed slimming and shaping cream samples are shown in Table 4.

[0072] Table 3: Grading Standards for Adverse Skin Reactions

[0073]

[0074] Table 4: Grading Standards for Adverse Skin Reactions

[0075]

[0076] As shown in Table 4, the skin patch test results were all negative and a few suspicious reactions. According to the cosmetic safety technical specifications for patch test results, the nine groups of two-phase mixed slimming and shaping creams prepared in this invention did not have any serious adverse reactions on the skin and had good safety.

[0077] Experimental Example 2: Efficacy Evaluation of a Two-Phase Blend Fat-Reducing and Shaping Cream

[0078] The method for evaluating the efficacy of the two-phase hybrid fat-reducing and body-shaping composition of the present invention is as follows:

[0079] Test population: 90 people were randomly selected, aged 21-54 years, with a body fat percentage (BMI) of 23-30, and who had maintained a stable weight for 3 months; they had no allergic diseases, no history of allergies to cosmetics or other topical preparations; they were able to understand the test process and voluntarily participated in the test. They were divided into 9 groups of 10 people each.

[0080] Test conditions: ambient temperature 20-22℃, humidity 40-60%, and real-time dynamic monitoring. Before each test, you need to sit quietly in the constant temperature and humidity room for 15 minutes.

[0081] Test method: Volunteers were randomly selected to use one leg of the eight two-phase mixed fat reduction and shaping composition samples in Example 1. The other leg was treated with a placebo (oil phase without C-phase plant essential oils combined with water phase without D-phase active ingredients) as a blank control. The amount used was 2-4 mL of oil phase per application and 4-8 g of water phase per application. The two phases were mixed and applied once in the morning and once in the evening. After application, massage for 5-10 minutes until absorbed. The treatment was continued for 2 weeks, and tests were conducted at week 0 and week 2.

[0082] Efficacy evaluation items and results

[0083] (1) Tightness of leg skin

[0084] The MPA580 skin elasticity tester was used to test the firmness of leg skin. The test principle is based on suction and stretching. A negative pressure is generated on the surface of the skin being tested, drawing the skin into a specific test probe. The depth to which the skin is drawn into the test probe is measured by a non-contact optical testing system. The test probe includes a light emitter and a receiver. The light ratio (the ratio of emitted light to received light) is directly proportional to the depth of skin absorption. The skin firmness is then determined by analysis using MPA software.

[0085] Select a specific area on the leg where the product was used, and assess the degree of change in skin firmness based on the difference in the skin firmness value F4 before and after use. △F4 = F4 (after use) - F4 (before use). The smaller the △F4 value, the greater the increase in firmness. The test results are shown in Table 5.

[0086] Table 5: Results of Skin Tightness Test

[0087]

[0088] As can be seen from the results in Table 5, the two-phase mixed slimming and shaping creams prepared in Examples 1-3 have lower F4 values ​​compared with Comparative Examples 1-5 and the control examples. The effect is more significant, especially after 2 weeks of product use, and the ΔF4 value is small, indicating that the two-phase mixed slimming and shaping creams prepared in this invention can effectively improve skin firmness.

[0089] (2) Three-point positioning method for measuring leg circumference

[0090] At the same height on both sides of the volunteer's thighs, three points at the same level were selected as markers. The leg circumference was measured before and after using the product (a two-phase slimming and shaping cream) or a placebo (an oil phase without C-phase plant essential oils combined with an aqueous phase without D-phase active ingredients). The change in leg circumference of the volunteer was calculated as Δ circumference (using the product) - Δ circumference (using the placebo), excluding the influence of changes in the volunteer's own body for comparison.

[0091] The criteria for judging the test results are as follows: significant effect - leg circumference decreased by 3cm or more; moderate effect - leg circumference decreased by 1-3cm; no obvious effect - leg circumference decreased by 1cm or less. The test results are shown in Table 6.

[0092] Table 6: Leg circumference test results

[0093] sample Significant effect / person It has a general effect per person No obvious effect / person Example 1 5 4 1 Example 2 7 3 0 Example 3 7 2 1 Comparative Example 1 3 4 3 Comparative Example 2 3 5 2 Comparative Example 3 2 4 4 Comparative Example 4 3 4 3 Comparative Example 5 3 6 1 Comparison Example 0 1 9

[0094] As shown in Table 6, the two-phase mixed fat-reducing and shaping creams prepared in Examples 1-3 have a more significant effect on reducing leg circumference compared to Control Examples 1-5, while the Control Examples have no obvious effect.

[0095] (3) Self-assessment questionnaire survey

[0096] After the second week of testing, questionnaires were distributed to volunteers to evaluate the slimming effect, skin firmness, weight change, and overall product performance of the 9 groups of two-phase mixed slimming and shaping creams before and after two weeks of use. The test results are shown in Table 7.

[0097] Table 7: Self-Assessment Results

[0098]

[0099]

[0100] The test results above show that the two-phase mixed fat-reducing and shaping cream of the present invention, including the examples, comparative examples, and control examples, all have good safety. Each example significantly reduces the volunteers' weight, decreases fat thickness, and improves skin elasticity, resulting in a significant fat-reducing and shaping effect. Both instrumental testing and volunteers' self-reported feelings demonstrate a clear improvement effect.

[0101] It should be noted that, for the sake of brevity, not all possible combinations of the various technical features in the above embodiments have been described. The embodiments described above only illustrate several implementation methods of the present invention, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the invention patent.

Claims

1. A two-phase blended fat-reducing and shaping cream, characterized in that, The two phases are an oil phase and a water phase; By weight percentage, the raw materials for preparing the oil phase include 40-70% natural vegetable oils, 5-20% vegetable essential oils, 10-30% isohexadecane, 5-15% caprylic / capric triglycerides, 1-5% cinnamon oil, 1-5% Artemisia argyi oil, 0.1-1% tocopherol, 0.1-1% bisabolol, and 0.1-1% pentaerythritol tetra(bis-tert-butylhydroxyhydrogenated cinnamic acid) ester. By weight percentage, the raw materials for preparing the aqueous phase include 0.01–0.2% quinacrine, 0.5–3% a complex of Paraguayan tea extract and small-fruited coffee leaf / seed extract, 0.5–3% a complex of caffeine and palmitoylcarnitine, 0.5–2.5% a complex of papaverine and cocoyl glucoside, 0.5–2% a complex of *Cymbidium goeringii* extract and gluconolactone, 0.3–1% p-hydroxyacetophenone, 0.01–0.5% a pH adjuster, 0.4–1.5% a thickener, 1–5% an emulsifier, 5–20% a humectant, 5–25% a skin moisturizer, and 50–80% water.

2. The two-phase mixed slimming and shaping cream according to claim 1, characterized in that, The natural plant oils in the oil phase are selected from one or more of the following: sweet almond oil, baobab seed oil, pomegranate seed oil, burr walnut seed oil, and evening primrose oil.

3. The two-phase mixed slimming and shaping cream according to claim 2, characterized in that, The mass ratio of sweet almond oil, baobab seed oil, pomegranate seed oil, burdock seed oil, and evening primrose oil in the natural plant oil is (15-25):(2-6):(10-20):(15-25):(1-5).

4. The slimming and shaping cream composed of two phases as described in claim 1, characterized in that, The plant essential oils in the oil phase are selected from two to four of the following: laurel leaf oil, saffron oil, gardenia oil, and bitter orange blossom oil, and are also compounded with two to five of the following: ginger root oil, benzoin resin extract, angelica extract, chuanxiong oil, and thyme oil.

5. The two-phase mixed slimming and shaping cream according to claim 4, characterized in that, The plant essential oils contain laurel leaf oil, saffron oil, ginger root oil, and benzoin resin extract in a weight percentage of (0.1-1):(1-5):(1-5):(1-5).

6. The two-phase mixed slimming and shaping cream according to claim 1, characterized in that, The thickener in the aqueous phase is selected from one or more of xanthan gum, ammonium acryloyl dimethyl taurate / VP copolymer, and acrylate / C10-30 alkanol acrylate crosspolymer.

7. The two-phase mixed slimming and shaping cream according to claim 1, characterized in that, The emulsifier in the aqueous phase is selected from one or more of PEG-20 methyl glucoside sesquistearate, methyl glucoside sesquistearate, and MONTANOV 202.

8. The two-phase mixed slimming and shaping cream according to claim 1, characterized in that, The humectant in the aqueous phase is selected from one or more of glycerin, 1,3-butanediol, 1,2-hexanediol, 1,3-propanediol, and sodium hyaluronate; the emollient in the aqueous phase is selected from one or more of triethylhexanoate, isononyl isononanoate, shea butter, coconut oil-caprylate / capric acid ester, and Atlantic sea bream oil.

9. A method for preparing the two-phase mixed slimming and shaping cream according to any one of claims 1 to 8, comprising the following steps: (1) Preparation of the oil phase Weigh each raw material according to the formula and divide it into phase A, phase B and phase C for later use; the raw material of phase A includes pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester and caprylic / capric triglyceride; the raw material of phase B includes natural plant oil and isohexadecane; the raw material of phase C includes cinnamon oil, artemisia oil, tocopherol, bisabolol and plant essential oil. S11: Add pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester and caprylic / capric triglyceride A phase raw materials into a homogenizing emulsifying pot, heat to 70-75℃, and stir to dissolve; S12: Cool down to 50-60℃, add the B phase raw material into the homogenizing emulsifier in sequence, and stir to disperse evenly; S13: Cool to 40-45℃, add C phase raw material sequentially, homogenize at 1000-1500 r / min for 3-5 min, cool to below 30℃ and discharge to obtain oil phase; (2) Preparation of the aqueous phase Weigh each raw material according to the formula and divide it into phases A, B, C, and D for later use. Phase A includes water, thickener, humectant, and p-hydroxyacetophenone. Phase B includes emulsifier and moisturizer. Phase C includes pH adjuster. Phase D includes 5-hydroxyflavone, Paraguayan tea extract and small-fruit coffee leaf / seed extract complex, caffeine and palmitoylcarnitine complex, papaverine and cocoyl glucoside complex, and spatholobus suberectus extract and gluconolactone complex. S21: Add the A phase raw material into the homogenizing emulsifying pot, heat to 70-75℃, and homogenize at 3000-3500r / min for 3-5min while stirring to dissolve; S22: Add the B phase raw material into the oil phase pot of the homogenizing emulsifier, heat to 80-85℃, and stir to disperse evenly; S23: Mix phase A and phase B raw materials, homogenize at 3000-4000 r / min at 70-80℃ for 5-10 min, and then keep warm at 80-85℃ for 15-20 min; S24: Stir and cool to 50-55℃, then add C phase raw material and homogenize at 3000-4000 r / min for 1-2 min; S25: Stir and cool to 40-45℃, then add D phase raw material, homogenize at 1000-1500r / min for 3-5min, cool to below 30℃ and discharge to obtain aqueous phase.

10. A method of using a two-phase mixed slimming and shaping cream as described in any one of claims 1 to 8, characterized in that, The oil phase and water phase are mixed in a volume ratio of 1:0.5 to 5.

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