Eye-protecting lotion for relieving eye fatigue and production process of eye-protecting lotion
By using a compound strain of lactic acid bacteria and yeast for bio-fermentation, the large molecules in traditional Chinese medicinal materials are broken down into smaller molecules, solving the problem of poor permeability and low absorption rate of traditional Chinese medicine preparations due to their large molecular weight, thus achieving a highly effective eye care solution to relieve eye fatigue.
Patent Information
- Application Number
- CN202511000105.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-21
- Publication Date
- 2025-11-28
AI Technical Summary
Existing eye care products have low absorption rates and poor bioavailability of active ingredients, while traditional Chinese medicine preparations suffer from poor absorption and easy destruction of active ingredients.
Biological fermentation using a complex of lactic acid bacteria and yeast breaks down macromolecular materials in Chinese medicinal herbs into smaller active substances such as oligosaccharides, amino acids, and aglycones. Low-temperature extraction and precision filtration ensure the stability and safety of the active ingredients.
It significantly improves the bioavailability and permeability of eye care solution, achieving rapid and significant fatigue relief while maintaining the product's effectiveness and safety.
Smart Images
Figure CN121015757A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to the technical field of eye-care water, in particular to eye-care water for relieving eye fatigue and a production process thereof. BACKGROUND
[0002] The application relates to the technical field of eye fatigue (also known as eye fatigue), which has become a very common sub-health state. Its main symptoms include dry eyes, eye dryness, acid swelling, burning sensation, blurred vision, wind-tearing and the like, which seriously affect the work efficiency and life quality of people. The products on the market for relieving eye fatigue are mainly chemical synthetic eye drops, such as artificial tears, vasoconstrictor or eye drops containing vitamin ingredients. Artificial tears can supplement tears and lubricate eyeballs in a short term, but the action time is limited and the eye function cannot be fundamentally improved. Although the eye drops containing vasoconstrictor ingredients can quickly eliminate red blood vessels, long-term use may lead to rebound hyperemia and aggravate the symptoms. Most of the commercially available eye drops contain preservatives, which may cause potential damage to the corneal and conjunctival cells of the eye surface, cause or aggravate dry eye syndrome, and are not suitable for long-term and frequent use. Another type is traditional Chinese herbal eye care products. Traditional Chinese medicine has a long history and rich theoretical basis in regulating eye discomfort. Through the combination of multiple medicinal materials as monarch, minister, assistant and guide, the symptoms and root causes can be treated. However, the traditional preparation method of Chinese medicine, such as water decoction, has obvious technical bottlenecks.
[0003] Therefore, the existing technology urgently needs a new eye-care product which can not only exert the comprehensive regulation advantages of Chinese herbal medicine formula, but also overcome the defects of traditional preparations such as poor absorption and easy damage of active ingredients. It is of important practical significance and broad market prospect to develop a pure natural, preservative-free, safe and non-irritating eye-care water with improved absorption rate and activity of active ingredients through modern biological technology to meet the safe and efficient eye health needs of the majority of people with eye fatigue.
[0004] The existing technical solution has the technical problems of low absorption rate of active ingredients and poor bioavailability. INVENTION CONTENT
[0005] In view of the deficiencies of the prior art, the application provides eye-care water for relieving eye fatigue and a production process thereof, which solves the technical problems of low absorption rate of active ingredients and poor bioavailability of the existing technical solution.
[0006] To achieve the above purpose, the application realizes the following technical scheme: eye-care water for relieving eye fatigue, comprising the following ingredients: eaglewood, wind-preventing plant, licorice, coptis, almond, angelica, copper green and alum.
[0007] Chenxiang is good for the eyes, can soothe the nerves, reduce stress, relieve eye muscle tension, promote blood circulation, reduce eye fatigue, and protect the eyes from excessive fatigue. Chenxiang is also used in eye care products, such as steam eye masks, which can relax the eyes and promote blood circulation. Qianfeng is mainly used in traditional Chinese medicine to dispel wind and relieve the surface, and to stop pain, and its effects on the eyes are mainly related to its ability to dispel wind, relieve itching, and relieve eye inflammation. It is often used in clinical practice to treat symptoms such as red and swollen eyes, tears, and eyelid itching caused by wind or damp heat. The main effects of licorice on the eyes are anti-oxidation, anti-inflammatory, and auxiliary relief of eye dryness. As a traditional Chinese herbal medicine, Huanglian has the core components (such as berberine) that have the effects of clearing heat and dampness, purging fire and detoxification, and is often used in traditional Chinese medicine to improve eye problems caused by liver fire or internal dampness, such as red and swollen eyes, and increased eye secretions. Almonds have some benefits for the eyes, mainly due to their rich content of vitamin E, antioxidant ingredients, and zinc and other nutrients. These substances play a role in protecting eye cells, delaying aging, and preventing oxidative damage. Copper green can remove nebula and improve eyesight, and has some effect on treating eye diseases such as nebula and ulcerative eye diseases. The astringent properties of alum may be used to relieve mild conjunctivitis or increased eye secretions, by diluting and washing the area to reduce secretions. Alum has an inhibitory effect on some bacteria, but modern clinical practice tends to use safer antibiotic eye drops.
[0008] Preferably, the selected formula has the following proportions: Chenxiang 15-25 parts; Qianfeng 8-15 parts; Gancao 5-10 parts; Huanglian 5-10 parts; Xingren 5-10 parts; Danggui 8-15 parts; Tonglu 0.5-2 parts; Mingmu 0.5-2 parts; The significant synergistic effect between the components makes the final product effective in relieving visual fatigue quickly, comprehensively, and gently, and suitable for long-term use.
[0009] The application discloses a production process of an eye-care water for relieving eye fatigue, which comprises the following steps: step (1), pretreatment, ingredients are weighed according to a formula, and then are crushed into fine powder and uniformly mixed; step (2), fermentation, the mixed fine powder is mixed with purified water, and is inoculated with fermentation bacteria, and then is subjected to fermentation at a set temperature and time to obtain a fermentation liquor; step (3), extraction, the fermentation liquor is subjected to low-temperature extraction, and is subjected to solid-liquid separation through centrifugation to obtain supernatant; step (4), purification, the supernatant is subjected to purification and sterilization through precision filtration to obtain a finished product stock solution; and step (5), the finished product stock solution is subjected to filling and sealing under aseptic conditions. The biological fermentation decomposes macromolecular polysaccharides, proteins, glycosides and the like in traditional Chinese medicinal materials into oligosaccharides, amino acids and aglycons through metabolic action of microorganisms, greatly improves bioavailability and permeability of active ingredients, and ensures that heat-sensitive active substances generated in the fermentation process and originally existing in the medicinal materials are not damaged, and meanwhile, invalid solid residues and miscellaneous bacteria are removed, so that the effectiveness, safety and stability of the final product are ensured.
[0010] Preferably, the fine powder in step (1) is crushed to pass through a 80-120 mesh sieve; the crushing of the ingredients to a particle size range of 80-120 meshes is a prerequisite for realizing efficient fermentation and extraction; the fine powder greatly increases the contact area of the ingredients and the fermentation medium, so that the microorganisms can more fully and uniformly act on the medicinal materials, and thus the fermentation efficiency and the conversion rate of active ingredients are significantly improved.
[0011] Preferably, the fermentation bacteria in step (2) are a composite bacteria of lactic acid bacteria and yeast; the fermentation temperature is 25-37 DEG C, and the fermentation time is 48-72 hours; the synergistic fermentation of lactic acid bacteria and yeast is a technical key of the process. The yeast can decompose macromolecular carbohydrates and proteins in the medicinal materials to provide nutrients required for the growth of the lactic acid bacteria; the lactic acid bacteria produce organic acids such as lactic acid to create an acidic environment, which not only inhibits the growth of miscellaneous bacteria, but also promotes the dissolution of various plant active ingredients. The synergistic action of the two produces metabolic products which are much more abundant than those produced by single bacteria fermentation, and thus the nutrition and efficacy of the product are enhanced.
[0012] Preferably, the low-temperature extraction temperature in step (3) is 4-10 DEG C; and the centrifugal speed is 3000-5000 r / min; the subsequent treatment of the fermentation liquor under the low-temperature condition of 4-10 DEG C can protect the active ingredients; and the low-temperature treatment can effectively remove insoluble impurities such as bacteria and medicinal residue particles in the fermentation liquor to obtain clear supernatant.
[0013] Preferably, the precision filtration in step (4) is sterilized by filtering through a microporous filter with a pore size of 0.22 μm; according to the standards of the international pharmaceutical industry and relevant regulations (such as the FDA guidelines), the pore size of the sterilization filter must be ≤0.22 μm, and compared with thermal sterilization (such as high-temperature high-pressure steam sterilization), the filtration sterilization is a "cold sterilization" technology, which can achieve product sterility without damaging the valuable heat-sensitive active ingredients in the product.
[0014] Preferably, the filling and sealing in step (5) is carried out in a sterile light-proof sealed plastic bottle and stored in a cold storage; the filtered and sterilized liquid medicine is filled into a pre-sterilized packaging bottle in a sterile environment and immediately sealed, which can prevent the product from being secondarily contaminated during the dispensing process and ensure the sterile state of the product before use; many active ingredients of traditional Chinese medicines are sensitive to light, and light can catalyze their oxidative decomposition, resulting in discoloration and reduced potency of the product; the light-proof packaging bottle can effectively prevent the influence of light on the product.
[0015] Beneficial effects
[0016] The present application provides a production process for an eye-protecting water for relieving eye fatigue, which adopts lactic acid bacteria and yeast complex strains for biological fermentation to decompose large molecular active substances in traditional Chinese medicinal materials into small molecular substances that are more easily absorbed by eye tissues, thereby fundamentally solving the technical problems of poor permeability, low absorption rate and poor bioavailability of traditional Chinese medicine preparations due to large molecular weight, enabling the effective ingredients to act more efficiently on the eyes, and achieving a faster and more significant fatigue relieving effect; the present application avoids the damage to effective ingredients caused by traditional high-temperature decoction; low-temperature extraction and microporous filter physical filtration sterilization are adopted; the valuable heat-sensitive and volatile active ingredients in agarwood and angelica are retained, ensuring the integrity of the efficacy of the eye-protecting water. BRIEF DESCRIPTION OF DRAWINGS
[0017] Figure 1 The present application provides a production process for an eye-protecting water for relieving eye fatigue. DETAILED DESCRIPTION
[0018] To further illustrate the technical means and effects adopted by the present application to achieve the predetermined purposes, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. The detailed description is as follows.
[0019] Please refer to Figure 1 The present application provides a technical solution: an eye-protecting water for relieving eye fatigue, which comprises the following ingredients: agarwood, wind-preventing plant, licorice, goldthread, apricot kernel, angelica, copper green and alum.
[0020] Lignum has benefits for the eyes, can soothe nerves, reduce stress, relieve eye muscle tension, promote blood circulation, reduce eye fatigue, and protect the eyes from excessive fatigue. Lignum is also used in eye care products, such as steam eye masks, to relax the eyes and promote blood circulation. Qianfeng is mainly used in traditional Chinese medicine to dispel wind and relieve the surface, and to stop pain, and its effects on the eyes are mainly related to its ability to dispel wind, relieve itching, and relieve eye inflammation. It is often used in clinical practice to treat symptoms such as red and swollen eyes, tears, and eyelid itching caused by wind or damp heat. The effects of licorice on the eyes are mainly reflected in its antioxidant and anti-inflammatory properties, as well as its ability to help relieve eye dryness. As a traditional Chinese herbal medicine, the core components of Huanglian, such as berberine, have the effects of clearing heat and dampness, purging fire and detoxifying, and are often used in traditional Chinese medicine to improve eye problems caused by liver fire or internal dampness, such as red and swollen eyes, and increased eye secretions. Almonds have certain benefits for the eyes, mainly due to their rich content of vitamin E, antioxidant ingredients, and zinc and other nutrients. These substances play a role in protecting eye cells, delaying aging, and preventing oxidative damage. Copper green can remove nebula and improve eyesight, and has certain effects on treating nebula and other eye diseases. The astringent properties of alum may be used to relieve mild conjunctivitis or increased eye secretions, and by diluting and washing the local area, the amount of secretions can be reduced. Alum has an inhibitory effect on some bacteria, but modern clinical practice tends to use safer antibiotic eye drops.
[0021] The present embodiment is further provided, and the specific formulation is as follows: Lignum 15-25 parts; Qianfeng 8-15 parts; Licorice 5-10 parts; Huanglian 5-10 parts; Almonds 5-10 parts; Danggui 8-15 parts; Copper green 0.5-2 parts; Alum 0.5-2 parts; The significant synergistic effect between each component makes the final product have a rapid and comprehensive effect in relieving visual fatigue, and the nature is mild, suitable for long-term use.
[0022] The application discloses a production process of an eye-care water for relieving eye fatigue, which comprises the following steps: Step (1): pretreatment, ingredients are weighed according to a formula, and then are crushed into fine powder and uniformly mixed; Step (2): fermentation, the mixed fine powder is mixed with purified water, and is inoculated with fermentation bacteria, and then is subjected to fermentation at a set temperature and time to obtain a fermentation liquor; Step (3): extraction, the fermentation liquor is subjected to low-temperature extraction, and is subjected to solid-liquid separation through centrifugation to obtain supernatant; Step (4): purification, the supernatant is subjected to purification and sterilization through precision filtration to obtain a finished product stock solution; and Step (5): the finished product stock solution is subjected to filling and sealing under aseptic conditions. The biological fermentation decomposes macromolecular polysaccharides, proteins, glycosides and the like in traditional Chinese medicinal materials into oligosaccharides, amino acids and aglycons through metabolic action of microorganisms, greatly improves bioavailability and permeability of active ingredients, and ensures that heat-sensitive active substances generated in the fermentation process and originally existing in the medicinal materials are not damaged, and meanwhile, invalid solid residues and miscellaneous bacteria are removed, so that the effectiveness, safety and stability of the final product are ensured.
[0023] In the step (1), the crushing into fine powder is through an 80-120 mesh sieve; the crushing of the ingredients to a particle size range of 80-120 meshes is a prerequisite for realizing efficient fermentation and extraction; and the fine powder greatly increases the contact area of the ingredients and the fermentation medium, so that the microorganisms can more fully and uniformly act on the medicinal materials, and thus the fermentation efficiency and the conversion rate of the active ingredients are significantly improved.
[0024] In the step (2), the fermentation bacteria are a composite bacteria of lactic acid bacteria and yeast bacteria; the fermentation temperature is 25-37 DEG C, and the fermentation time is 48-72 hours; and the synergistic fermentation of the lactic acid bacteria and the yeast bacteria is a technical key of the process. The yeast bacteria can decompose macromolecular carbohydrates and proteins in the medicinal materials to provide nutrients required for growth of the lactic acid bacteria; and the lactic acid bacteria produce organic acids such as lactic acid to create an acidic environment, which not only inhibits growth of miscellaneous bacteria, but also promotes dissolution of various plant active ingredients. The synergistic action of the two produces metabolic products which are much more abundant than those produced by single bacteria fermentation, and thus the nutrition and efficacy of the product are enhanced.
[0025] In the step (3), the low-temperature extraction temperature is 4-10 DEG C; and the centrifugal speed is 3000-5000 r / min; and the subsequent treatment of the fermentation liquor under the low-temperature condition of 4-10 DEG C can protect the active ingredients; and the treatment can effectively remove insoluble impurities such as bacteria bodies and medicinal residue particles in the fermentation liquor to obtain clear supernatant.
[0026] The embodiment is further provided with the following arrangement: the precision filtration in step (4) is performed by using a microporous filter with a pore size of 0.22 μm for sterilization; according to the standards of international pharmaceutical industry and relevant regulations (such as FDA guidelines), the pore size of a sterilization-grade filter must be ≤0.22 μm; compared with thermal sterilization (such as high-temperature and high-pressure steam sterilization), the filtration sterilization is a "cold sterilization" technology, which can achieve product sterility without damaging the valuable heat-sensitive active ingredients in the product.
[0027] The embodiment is further provided with the following arrangement: the filling and sealing in step (5) is performed in a sterile light-proof sealed plastic bottle and the product is stored in a cold storage; the filtered and sterilized medicinal liquid is filled into a pre-sterilized packaging bottle in a sterile environment and immediately sealed, which can prevent the product from being secondarily contaminated during the dispensing process and ensure the sterile state of the product before use; many active ingredients of traditional Chinese medicines are sensitive to light, and light can catalyze the oxidative decomposition of the active ingredients, resulting in discoloration and reduced potency of the product; the light-proof packaging bottle can effectively prevent the influence of light on the product.
[0028] The detailed connection means is a technology known in the art; as shown in the following table: Figure 1 The first step: raw material proportioning and pretreatment
[0029] The raw materials are accurately weighed according to the following proportions: eaglewood 20 g, prepared rhizoma 12 g, licorice 8 g, goldthread 8 g, apricot kernel 8 g, angelica 12 g, copper green 1 g, and alum 1 g.
[0030] The weighed mixed raw materials are put into a pulverizer for pulverization until the powder can pass through a 100-mesh sieve to obtain a uniform mixture of fine powder for use.
[0031] The above-mentioned mixture of fine powder is added to a fermentation tank containing 1000 ml of purified water and stirred uniformly. Then, a composite strain composed of Lactobacillus plantarum and Saccharomyces cerevisiae is inoculated. The fermentation tank is sealed and fermentation is performed at a constant temperature of 30℃ for 60 hours to obtain a fermentation liquid.
[0032] The fermentation liquid after fermentation is placed in a low-temperature environment of 4℃ for subsequent treatment. A high-speed refrigerated centrifuge is used for centrifugation at a speed of 4000 r / min for 15 minutes for solid-liquid separation. The supernatant is carefully sucked and the bottom of the bacterial body and dreg sediment is discarded.
[0033] The obtained supernatant is sequentially filtered through a filter membrane with a larger pore size to remove residual small particles. Then, the primary filtrate is precisely filtered through a sterile microporous filter with a pore size of 0.22 μm to completely remove all bacteria and achieve "cold sterilization", thereby obtaining a clear and sterile finished product stock solution.
[0034] The product solution is filled into 10ml capacity brown light-shielded eye drop plastic bottles which have been sterilized by gamma rays in a clean area meeting GMP standards, and immediately sealed by hot melting. The sealed product eye drops are subjected to final quality inspection, and after passing the inspection, are labeled and stored under refrigeration at 4-8℃.
[0035] The prepared eye drops are clear light yellow liquid without any visible suspended matter, and are mild and non-irritating. After trial, the eye drops can rapidly relieve eye dryness and acid-bloat caused by long-time use of electronic products, and the effect is significant and persistent, proving that the eye drops prepared by the technical scheme have excellent effect in relieving visual fatigue, and are safe for long-term use due to their sterile and preservative-free characteristics.
[0036] It should be noted that in this article, relational terms such as first and second are used merely to distinguish one entity or action from another, and do not necessarily require or imply that there is any such actual relationship or order between these entities or actions.
[0037] The above is only the preferred embodiment of the present application, and does not limit the present application in any form. Although the present application has been disclosed as above with the preferred embodiment, it is not intended to limit the present application. Any person skilled in the art can make some changes or modifications to the above disclosed technical content without departing from the scope of the present application, and any equivalent embodiments with equivalent changes are still within the scope of the present application.
Claims
1. An eye care solution for relieving eye fatigue, characterized in that, It includes the following ingredients: agarwood, saposhnikovia root, licorice root, coptis root, apricot kernel, angelica root, verdigris, and alum.
2. An eye care solution for relieving eye fatigue according to claim 1, characterized in that, The selected formula proportions are as follows: agarwood 15-25 parts; saposhnikovia root 8-15 parts; licorice root 5-10 parts; coptis root 5-10 parts; apricot kernel 5-10 parts; angelica root 8-15 parts; verdigris 0.5-2 parts; alum 0.5-2 parts.
3. The production process of an eye-care solution for relieving eye fatigue according to claim 1 or 2, characterized in that, The process includes the following steps: Step (1): Pretreatment, weigh each raw material according to the formula ratio, crush them into fine powder and mix them evenly; Step (2): Fermentation, mix the mixed fine powder with purified water, inoculate with fermentation bacteria, and ferment at the set temperature and time to obtain fermentation liquid; Step (3): Extraction, extract the fermentation liquid at low temperature and separate the solid and liquid by centrifugation to obtain the supernatant; Step (4): Purification, purify and sterilize the supernatant by precision filtration to obtain the finished product stock solution; Step (5): fill and seal the finished product stock solution under aseptic conditions.
4. The production process of an eye-care solution for relieving eye fatigue according to claim 3, characterized in that, The pulverization process described in step (1) involves passing the powder through an 80-120 mesh sieve.
5. The production process of an eye-care solution for relieving eye fatigue according to claim 3, characterized in that, The fermentation strain mentioned in step (2) is a compound strain of lactic acid bacteria and yeast; the fermentation temperature is 25-37℃ and the fermentation time is 48-72 hours.
6. The production process of an eye-care solution for relieving eye fatigue according to claim 3, characterized in that, The low-temperature extraction temperature in step (3) is 4-10℃; the centrifugation speed is 3000-5000r / min.
7. The production process of an eye-care solution for relieving eye fatigue according to claim 3, characterized in that, The precision filtration described in step (4) uses a microporous membrane with a pore size of 0.22 μm for filtration and sterilization.
8. The production process of an eye-care solution for relieving eye fatigue according to claim 3, characterized in that, The filling and sealing process described in step (5) involves filling and sealing the product in sterile, light-proof, sealed plastic bottles and storing it under cold conditions.