Composite analysis system

Abstract

The purpose of the present invention is to reduce the movement distance of an operator and reduce the workload. A composite analysis system (1) is provided with a blood cell analysis device (2), a blood coagulation measurement device (3), and a transport device (4) having a transport path (50). The blood cell analyzer (2) and the blood coagulation measurement device (3) are disposed along a first side surface of the transport device (4). The blood cell analysis device (2), the blood coagulation measurement device (3), and the transport device (4) are disposed in a position and orientation at which at least one of the following operations can be performed: an operation on a power operation reception unit of the blood cell analysis device (2) and the blood coagulation measurement device (3) from a second side surface side of the transport device (4); operation of the consumable placement part of each device from the second side surface side of the conveying device (4); operation of a terminal device of each device from the second side surface side of the conveying device (4); and operating the maintenance management object part of each device from the second side surface side of the conveying device (4).

Description

Technical Field

[0001] This invention relates to a composite analysis system, and more specifically, to a composite analysis system comprising a blood cell analysis device and a blood coagulation assay device. Background Technology

[0002] Currently, a composite analysis system integrating a blood cell analysis device and a blood coagulation assay device is known. For example, Patent Document 1 discloses a composite analysis system comprising test blocks including blood test lines, coagulation test lines, etc., a pretreatment block in which common processing is performed in each test block, and an unmanned transport vehicle positioned between the pretreatment block and the test blocks for sample transfer between the two. In the system of Patent Document 1, the sample transport paths of each test line extend parallel to each other, and the test lines are arranged side by side in the front-to-back direction to facilitate the movement of the unmanned transport vehicle between the pretreatment block and each test line.

[0003] Existing technical documents Patent documents Patent Document 1: Japanese Patent Application Publication No. 2000-19180 Summary of the Invention The problem that the invention aims to solve The composite analysis system in Patent Document 1 may be effective in large-scale facilities, but in facilities of medium to small scale, the large sample size available in large-scale facilities is unavailable, and the unmanned transport vehicle may become redundant equipment. In particular, it is difficult to effectively utilize such a system in facilities of medium to small scale.

[0004] In order to make the composite analysis system effective, it is also considered to connect the inspection lines by a transport path. However, in the system of Patent Document 1, since the inspection lines are arranged side by side in the front-back direction, the following problem arises: when performing operations on each inspection line or replacing consumables, the movement between the inspection lines requires effort and time, which reduces the efficiency of the operation.

[0005] Technical solutions for solving the problem The present invention provides a composite analysis system (1) comprising: a blood cell analysis device (2); a blood coagulation assay device (3); and a transport device (4) capable of transporting the sample to a first acquisition position (P2) of the blood cell analysis device (2) and a second acquisition position (P3) of the blood coagulation assay device (3), having a first side and a second side opposite to the first side, the blood cell analysis device (2) and the blood coagulation assay device (3) being arranged along the first side of the transport device (4), and the blood cell analysis device (2), the blood coagulation assay device (3) and the transport device (4) being arranged in a position and orientation capable of performing at least one of the following operations: (a) Operation of the power operation receiving unit from the second side of the transport device (4), the power operation receiving unit accepting the power operation of the blood cell analysis device (2) and the power operation of the blood coagulation assay device (3); (b) Operation of the consumable placement section from the second side of the transport device (4), the consumable placement section being used to place consumables used in the blood cell analyzer (2) and consumables used in the blood coagulation assay device (3); (c) Operation of the terminal device from the second side of the transport device (4), wherein the terminal device performs at least one of receiving operation instructions and displaying information from the blood cell analyzer (2), and at least one of receiving operation instructions and displaying information from the blood coagulation assay device (3); and (d) Operation of the maintenance management object section from the second side of the transport device (4), wherein the maintenance management object section performs maintenance management of the blood cell analysis device (2) and the blood coagulation determination device (3).

[0006] Invention Effects According to the composite analysis system of the present invention, each device can be operated and performed from a second side opposite to the first side of the transport device on which each device is arranged, thus avoiding inefficient actions such as moving around the system as in the past. This reduces the operator's travel distance and workload. For example, the operator can smoothly perform operations such as operating each device, replenishing or replacing reagents, replenishing or replacing consumables, handling errors, and maintaining and repairing the parts under maintenance. Attached Figure Description

[0007] Figure 1 This is a diagram showing the appearance of a composite analysis system as an example of an implementation method.

[0008] Figure 2This is a diagram showing the structure of a composite analysis system as an example of an implementation method.

[0009] Figure 3 This is a diagram showing the structure of a blood cell analysis device.

[0010] Figure 4 This is a diagram showing the upper part of the blood cell analyzer, indicating the state after the cover is opened.

[0011] Figure 5 This diagram shows the upper part of a blood cell analyzer, illustrating a manual measurement of a substance requiring precision control.

[0012] Figure 6 This is a diagram showing the lower part of the blood cell analyzer, indicating the state after the door is opened.

[0013] Figure 7 This is an example diagram showing the operation screen of a blood cell analyzer.

[0014] Figure 8 This is an example of a display screen showing the analysis results of a blood cell analyzer.

[0015] Figure 9 This is a diagram showing the structure of a blood coagulation testing device.

[0016] Figure 10 This is a diagram showing the upper part of the blood coagulation measuring device, indicating the state after the cover is opened.

[0017] Figure 11 This is a diagram showing the lower part of the blood coagulation measuring device, indicating the state after the door is opened.

[0018] Figure 12 This is an example diagram showing the operation screen of a blood coagulation testing device.

[0019] Figure 13 This is an example of a display screen showing the analysis results of a blood coagulation assay device.

[0020] Figure 14 This is a diagram representing the first variant of the composite analysis system.

[0021] Figure 15 This is a diagram representing the second variation of the composite analysis system.

[0022] Figure 16 This is a diagram representing the third variation of the composite analysis system.

[0023] Figure 17 This is a diagram representing the fourth variation of the composite analysis system. Detailed Implementation

[0024] Hereinafter, embodiments of the composite analysis system of the present invention will be described in detail with reference to the accompanying drawings. The embodiments described below are merely examples, and the present invention is not limited to the embodiments described below. In addition, the present invention includes arrangements in which the constituent elements of the various embodiments and variations described below are selectively combined.

[0025] Figure 1 This is a perspective view showing the appearance of the composite analysis system 1, which is an example of an implementation method. Figure 2 This is a diagram showing the structure of composite analysis system 1. (For example...) Figure 1 and Figure 2 As shown, the composite analysis system 1 includes a blood cell analyzer 2, a blood coagulation assay 3, and a transport device 4. The blood cell analyzer 2 is used to count blood cells in a blood sample, and the blood coagulation assay 3 is used to measure hemostatic components in the blood sample. The transport device 4 also includes a sample collection position P2 for collecting samples from the blood cell analyzer 2 and a sample collection position P3 for collecting samples from the blood coagulation assay 3, a sample setting section for setting samples, and a sample collection section for collecting samples after testing. The transport device 4 has a first side and a second side opposite to the first side, and the blood cell analyzer 2 and the blood coagulation assay 3 are arranged along the first side of the transport device 4. Furthermore, the transport device 4 has a continuous transport path 50. It should be noted that the continuous transport path 50 may not consist of a single transport path, but may be a transport path connecting multiple transport paths. However, other transport devices are not required to lift sample containers or racks for transporting sample containers or racks at the connection points of multiple transport paths.

[0026] In the composite analysis system 1, racks 100 and 110, which respectively hold sample containers 101 and 111 containing samples, are transported to the hematology analyzer 2 or the blood coagulation assay 3 via a transport device 4. The composite analysis system 1 includes a rack placement section 5 for placing the racks 100 and 110, and rack recovery sections 6A and 6B for recovering the racks 100 and 110, respectively. In this embodiment, the rack placement section 5 functions as the sample placement section, and the rack recovery sections 6A and 6B function as sample recovery sections.

[0027] Shelf 100 is used to hold sample container 101 and transport it to blood cell analyzer 2. After the sample is measured, it is returned to shelf collection unit 6A. Shelf 110 is used to hold sample container 111 and transport it to blood coagulation analyzer 3. After the sample is measured, it is returned to shelf collection unit 6B. That is, shelves 100 and 110 are placed in a shared shelf placement unit 5 and are returned to their respective shelf collection units 6A and 6B. Shelves 100 and 110 may have the same shape and size, for example, but may have different shapes and sizes as long as they can be placed in shelf placement unit 5 and transported by transport device 4.

[0028] The sample container 101, held by rack 100 and transported to the hematology analyzer 2, and the sample container 111, held by rack 110 and transported to the blood coagulation assay 3, typically contain different samples. Because the samples in sample containers 101 and 111 are prepared using different methods, they differ even if the subjects are the same. For example, the sample in sample container 101 may be whole blood, while the sample in sample container 111 may be plasma. In this embodiment, the rack mounting section 5 is connected to the transport path 50 between the hematology analyzer 2 and the blood coagulation assay 3. Furthermore, racks 100 and 110 are transported separately to each device from the rack mounting section 5 in opposite directions. Therefore, in this embodiment, the two types of sample containers 101 and 111 cannot be placed on the same rack.

[0029] Shelf 100 has multiple holding sections capable of holding sample containers 101 one by one, holding multiple (e.g., five, six, or ten) sample containers 101 in a row. Shelf 110 similarly holds multiple sample containers 111 in a row. In this embodiment, the number of sample containers that shelf 100 can hold is the same as the number of sample containers that shelf 110 can hold, but they may also be different. As described above, only sample containers 101 are held on shelf 100, and only sample containers 111 are held on shelf 110, but the composite analysis system 1 may also include a rearrangement device capable of transferring sample containers to another shelf. In this case, shelf 100 holding only sample containers 101 and shelf 110 holding only sample containers 111 are prepared by the rearrangement device, so that the operator can place both types of sample containers 101 and 111 on the same shelf.

[0030] The composite analysis system 1 is constructed by arranging the blood cell analyzer 2, the blood coagulation assay device 3, the rack mounting section 5, and the rack retrieval sections 6A and 6B in a row, and connecting each device via the transport path 50 of the transport device 4. Hereinafter, for ease of explanation, terms indicating front-back, left-right, and up-down directions will be used. Left and right in the composite analysis system 1 refer to left and right when observing the system from the operator's standing position. In this embodiment, the blood cell analyzer 2 and the rack retrieval section 6A are located on the right side of the rack mounting section 5, and the blood coagulation assay device 3 and the rack retrieval section 6B are located on the left side of the rack mounting section 5.

[0031] In this manual, the operator's standing position refers to the area where the operator stands when performing tasks such as operating various devices, replenishing or replacing reagents, replenishing or replacing consumables, handling errors, and maintaining or repairing the parts under maintenance. The multi-analytical system 1 is typically positioned in the inspection chamber with a wider open space in front of the system than behind it, i.e., on the side where the operator stands. Alternatively, the multi-analytical system 1 may be positioned behind the system along the side wall of the inspection chamber or the rear of another analytical system.

[0032] The composite analysis system 1 comprises two hematology analyzers 2A and 2B and two coagulation assays 3A and 3B. Since hematology analyzers 2A and 2B each contain two assay units 10A and 10B, the composite analysis system 1 can also be said to have four hematology analyzers. Hematology analyzers 2A and 2B each have a transport unit 18 shared by assay units 10A and 10B, and are configured to allow assay units 10A and 10B to share the sample assay. It should be noted that the number of hematology analyzers 2 and coagulation assays 3 is not particularly limited; for example, there can be one of each, or more than three. The number of hematology analyzers 2 and coagulation assays 3 can be the same or different.

[0033] The composite analysis system 1 further includes a power operation receiving unit for receiving power operations from the hematology analyzer 2 and the blood coagulation assay 3, a consumable storage unit for storing consumables used in each device, and a maintenance management unit for performing maintenance management on each device. The power operation receiving unit may be a shared power operation receiving unit for receiving power operations from both the hematology analyzer 2 and the blood coagulation assay 3, or it may have a first power operation receiving unit for receiving power operations from the hematology analyzer 2 and a second power operation receiving unit for receiving power operations from the blood coagulation assay 3. The power operation receiving unit may also include at least one of a start-up indication receiving unit and a stop-down indication receiving unit, described later. The start-up indication receiving unit may be a shared start-up indication receiving unit for receiving start-up indications from both the hematology analyzer 2 and the blood coagulation assay 3, or it may have a first start-up indication receiving unit for receiving start-up indications from the hematology analyzer 2 and a second start-up indication receiving unit for receiving start-up indications from the blood coagulation assay 3. The shut-off indicator receiving section can be a shared shut-off indicator receiving section that receives shut-off indicators from both the hematology analyzer 2 and the blood coagulation assay 3, or it can have a first shut-off indicator receiving section that receives shut-off indicators from both the hematology analyzer 2 and the blood coagulation assay 3. The consumable storage section can also include at least one of the following: a precision management material storage section, a reagent storage section, and a cleaning solution storage section. The consumable storage section can be a shared consumable storage section for both the first consumable used by the hematology analyzer 2 and the second consumable used by the blood coagulation assay 3, or it can have a first consumable storage section for the first consumable used by the hematology analyzer 2 and a second consumable storage section for the second consumable used by the blood coagulation assay 3. The reagent storage section can be a shared reagent storage section for both the first reagent used by the hematology analyzer 2 and the second reagent used by the blood coagulation assay 3, or it can have a first reagent storage section for the first reagent used by the hematology analyzer 2 and a second reagent storage section for the second reagent used by the blood coagulation assay 3. The cleaning solution placement section can be a shared section for both the first cleaning solution used by the hematology analyzer 2 and the second cleaning solution used by the blood coagulation assay 3, or it can have a first cleaning solution placement section for the first cleaning solution used by the hematology analyzer 2 and a second cleaning solution placement section for the second cleaning solution used by the blood coagulation assay 3. The maintenance and management target section can also include at least one of the following: a pipette, an error handling section, and a repair target section. The maintenance and management target section can be a shared section for both the maintenance and management of the hematology analyzer 2 and the blood coagulation assay 3, or it can have a first maintenance and management target section for the maintenance and management of the hematology analyzer 2 and a second maintenance and management target section for the maintenance and management of the blood coagulation assay 3.The error handling unit can be a shared error handling unit for errors generated in the blood cell analyzer 2 and the blood coagulation assay 3, or it can have a first error handling unit for errors generated in the blood cell analyzer 2 and a second error handling unit for errors generated in the blood coagulation assay 3. The maintenance target unit can be a shared maintenance target unit for maintenance of the blood cell analyzer 2 and the blood coagulation assay 3, or it can have a first maintenance target unit for maintenance of the blood cell analyzer 2 and a second maintenance target unit for maintenance of the blood coagulation assay 3. Furthermore, the composite analysis system 1 has a terminal device with the functions of receiving operation instructions from the blood cell analyzer 2 and the blood coagulation assay 3, displaying analysis results, or both. The terminal device can be a shared terminal device for the blood cell analyzer 2 and the blood coagulation assay 3, or it can have a first terminal device for the blood cell analyzer 2 and a second terminal device for the blood coagulation assay 3. Hereinafter, the term "measurement result" will also be used, but "analysis result" and "measurement result" are synonymous.

[0034] The blood cell analyzer 2 and the blood coagulation assay 3 are arranged side-by-side in the left-right direction as described above, and the transport path 50 of the transport device 4 extends straight in the left-right direction. The blood cell analyzer 2 and the blood coagulation assay 3 are arranged along the first side of the transport device 4. In this embodiment, the side of the transport device 4 along the transport path 50 is the first side side, and the other side along the transport path 50 is the second side side. Alternatively, the first side side of the transport path 50 can also be referred to as the rear side of the transport path 50, and the second side side of the transport path 50 can also be referred to as the front side of the transport path 50. A portion of the structure of the blood cell analyzer 2 and the blood coagulation assay 3 may also be arranged directly below the transport path 50, but not on the second side side of the transport path 50. As detailed later, the blood cell analyzer 2, the blood coagulation assay 3, and the transport device 4 are arranged in a position and orientation capable of performing at least one of the following operations: (a) Operation of the power supply receiving unit of the blood cell analyzer 2 and the blood coagulation assay 3 from the second side of the transport device 4; (b) Operation of the consumable storage section of the blood cell analyzer 2 and the blood coagulation assay 3 from the second side of the transport device 4; (c) Operation of the terminal devices of the blood cell analyzer 2 and the blood coagulation assay 3 from the second side of the transport device 4; and (d) Operation of the maintenance and management unit of the blood cell analyzer 2 and the blood coagulation assay 3 from the second side of the transport device 4.

[0035] According to the composite analysis system 1, the blood cell analyzer 2 and the blood coagulation assay 3 can only be operated from the second side (front) of the transport device 4. Therefore, inefficient actions such as moving around the system as in the past can be avoided. That is, the operator can operate each device from one side of the transport device 4 (transport path 50), i.e., the second side, without having to move to the first side of the transport device 4. As a result, the operator's travel distance is shortened, and the operator's workload is reduced.

[0036] Figure 2 This refers to the operating section 2Z of the blood cell analyzer 2 and the operating section 3Z of the blood coagulation assay 3. Operating sections 2Z and 3Z are locations where at least one of a power operation receiving section, a consumable storage section, a terminal device, and a maintenance and management section is installed. Operating sections 2Z and 3Z are locations where the operator performs operations; specifically, they include various operation buttons (described later), reagent and sample storage sections, front covers 11a and 31a, anti-backflow chambers 25 and 46, etc. Additionally, the screens of displays 17 and 37 (described later) may be installed in operating sections 2Z and 3Z. At least one of the power operation receiving section, consumable storage section, terminal device, and maintenance and management section is located on the first side of the transport device 4, and is operated from the second side of the transport device 4 across the transport device 4. Furthermore, at least one of the power operation receiving unit, consumable placement unit, terminal device, and maintenance management object unit, which is operated across the second side of the transport device 4, is arranged such that the shortest horizontal distance from the end of the second side of the transport device 4 is within a length range of 700 mm. In this embodiment, all of the power operation receiving unit, consumable placement unit, terminal device, and maintenance management object unit are arranged on only the first side of the transport device 4 or directly below the first side of the transport device 4 and the transport path 50. Alternatively, at least one of the power operation receiving unit, consumable placement unit, terminal device, and maintenance management object unit may be movable toward the second side of the transport device 4. That is, at least one of them may be movable toward the second side of the transport device 4 and be operated on the second side.

[0037] As described above, the blood cell analyzer 2 includes two measuring units 10A and 10B. Measuring units 10A and 10B are arranged adjacent to each other in the left-right direction and have the same shape and size. Figure 4 As shown, measuring units 10A and 10B each have a frame 11 in a generally rectangular parallelepiped shape. The frame 11 has an openable and closable front cover 11a. The front cover 11a can be rotated open from bottom to top, and by opening the front cover 11a, the interior of the device can be opened.

[0038] Measurement units 10A and 10B include a sample placement section 19 for placing a sample container, an open / close button 20 for opening and closing the sample placement section 19, and a measurement start button 21 for starting the measurement of the sample placed on the sample placement section 19. The sample placement section 19 corresponds to the aforementioned consumable placement section, and the open / close button 20 and the measurement start button 21 correspond to the aforementioned operation instruction receiving section of the terminal device.

[0039] return Figure 1 and Figure 2 The blood cell analyzer 2 includes a transport unit 18 connected to the main transport path constituting the transport path 50. The transport unit 18 is a secondary transport path for introducing the rack 100 from the first transport path 51, transporting it to the sample acquisition position P2 of the blood cell analyzer 2, and returning it to the first transport path 51, which is the main transport path connecting the rack mounting section 5 to the rack recovery section 6A. The transport unit 18, together with the first transport path 51, forms part of the transport path 50 of the transport device 4. The transport unit 18 is shared by the measurement units 10A and 10B, and transports the sample container 101 held on the rack 100 to the acquisition position P2 of the measurement unit 10A or measurement unit 10B.

[0040] The blood cell analyzer 2 also includes a resolution device 16 and a display 17. The resolution device 16 is a computer that analyzes the results of measurements performed by the measurement units 10A and 10B, and is communicatively connected to the measurement units 10A and 10B. Figure 1 In the example shown, a side frame 11b is mounted on the side of the frame 11, and a resolution device 16 and a display 17 are configured on the side frame 11b. One resolution device 16 and one display 17 are respectively provided on the blood cell analysis devices 2A and 2B.

[0041] The analyzer 16 can also be communicatively connected to the host 120, which registers sample identification codes such as sample IDs and measurement items. The composite analysis system 1 is installed, for example, in a hospital examination room. In this case, an example of the host 120 is a clinical examination information system that connects to multiple examination devices and centrally manages sample information or measurement instructions. Furthermore, the analyzer 16 has a power button 16a located in a position operable from the front of the composite analysis system 1. It should be noted that the functions of the analyzer 16 can also be integrated into the measurement units 10A and 10B.

[0042] Display 17 is a display unit that displays measurement results, etc. In this embodiment, it is a touch panel type display that also functions as an input device. Display 17 is connected to the analysis device 16 and is communicatively connected to the measurement units 10A and 10B via the analysis device 16. For example, operation signals of the display 17, which is a touch panel, are sent to the measurement units 10A and 10B via the analysis device 16. It should be noted that display 17 may also be integrated with the measurement units 10A and 10B.

[0043] like Figure 10 As shown, the blood coagulation assay device 3 has a generally rectangular frame 31. The frame 31 has an openable and closable front cover 31a. The front cover 31a is rotated open from bottom to top, allowing the interior of the device to be opened. Furthermore, the blood coagulation assay device 3 has a main power button 35 for activating the device and a measurement start button 39 for starting manual sample measurement. The main power button 35 corresponds to the power operation receiving unit, and the measurement start button 39 corresponds to the terminal device.

[0044] The main power button 35 and the measurement start button 39 are located on the front surface of the frame 31 facing the front of the composite analysis system 1. In this case, each button can be easily operated from the second side of the transport device 4. The main power button 35 is located directly below the transport path 50 of the transport device 4, and the measurement start button 39 is located above and behind the transport path 50. In addition, the blood coagulation assay device 3 has a sample placement section 49 for placing sample containers. The sample placement section 49 is equivalent to the aforementioned consumable placement section and is located adjacent to the transport path 50.

[0045] Additionally, the blood coagulation testing device 3 includes a transport unit 38 connected to the main transport path constituting the transport path 50. The transport unit 38 is a secondary transport path used to introduce the rack 110 from the second transport path 52, transport it to the sample acquisition position P3 of the blood coagulation testing device 3, and return it to the second transport path 52, which is the main transport path connecting the rack mounting section 5 to the rack recovery section 6B. The transport unit 38 and the second transport path 52 together constitute part of the transport path 50 of the transport device 4.

[0046] return Figure 1 and Figure 2The blood coagulation assay apparatus 3 includes a main body 30 housed in a housing 31, an analytical device 36, and a display 37. The analytical device 36 is a computer that analyzes the results of measurements performed by the main body 30 and is communicatively connected to the main body 30. In this embodiment, the main body 30 is the unit that measures the optical information of the sample, referring to the part of the blood coagulation assay apparatus 3 other than the analytical device 36 and the display 37. Figure 1 In the example shown, a display 37 is mounted on the side of the frame 31, and a resolution device 36 is housed on the side bracket 31b behind the display 37.

[0047] The analysis device 36 can also be communicatively connected to the host 120. The display 37 is a display unit that displays measurement results, etc., and in this embodiment, it is a touch panel type display that also functions as an input device. The display 37 is connected to the analysis device 36 and is communicatively connected to the device body 30 via the analysis device 36. For example, the operation signals of the display 37, which is a touch panel, are sent to the device body 30 via the analysis device 36. It should be noted that the functions of the analysis device 36 can also be built into the device body 30, and the display 37 can also be integrated with the device body 30.

[0048] The transport device 4 includes a transport path 50 and a transport control unit 54 for controlling the operation of the transport path 50. As described above, the transport path 50 includes a first transport path 51 to the transport rack 100 of the blood cell analyzer 2, a second transport path 52 to the transport rack 110 of the blood coagulation assay device 3, a transport unit 18 serving as a first auxiliary transport path, and a transport unit 38 serving as a second auxiliary transport path. The transport path 50 may include, for example, a belt conveyor for the transport racks 100 and 110 in a left-right direction. The transport unit 18 is connected to the first transport path 51, and the transport unit 38 is connected to the second transport path 52.

[0049] The main transport path connecting the rack mounting section 5 to the rack retrieval sections 6A and 6B, namely the first transport path 51 and the second transport path 52, are formed in a straight line without bending in the middle. The first transport path 51 extends straight from the rack mounting section 5 past the front of the measurement units 10A and 10B of the blood cell analyzer 2 to the rack retrieval section 6A. A sample acquisition position P2 for the blood cell analyzer 2 can also be set on the first transport path 51, but when two blood cell analyzers 2A and 2B are provided, setting the acquisition position P2 on the transport unit 18, which serves as a secondary transport path, enables more efficient sample measurement. In this case, for example, when transporting the rack 100 to the blood cell analyzer 2A and performing sample measurement, the rack 100 can also be transported to the blood cell analyzer 2B and sample measurement can also be performed.

[0050] The second transport path 52 extends straight from the rack mounting section 5, passing in front of the main body 30 of the blood coagulation assay device 3, to the rack recovery section 6B. The second transport path 52 can also have a sample acquisition position P3 for the blood coagulation assay device 3. However, when two blood coagulation assay devices 3A and 3B are provided, setting the acquisition position P3 on the transport unit 38, which serves as a secondary transport path, enables more efficient sample measurement. It should be noted that the portion of the transport path 50 connected to the rack mounting section 5, for example, also serves as the first transport path 51 and the second transport path 52, and includes a belt conveyor for transporting the rack in the left-right direction. In this embodiment, the blood cell analyzer 2 and the blood coagulation assay device 3 are arranged with the same orientation as the main transport path. The operating section 2Z of the blood cell analyzer 2 and the operating section 3Z of the blood coagulation assay device 3 both face forward of the composite analysis system 1.

[0051] Details will be described later, but the blood cell analysis device 2 is configured such that the sample container 101 is inserted into the device at the acquisition position P2 of the transport unit 18, and the sample is aspirated within the device. The blood coagulation assay device 3 is configured such that the sample is aspirated at the acquisition position P3 of the transport unit 38. The blood cell analysis device 2 has a suction tube 14a that pierces the stopper attached to the sample container 101 and aspirates the sample (see below). Figure 3 Additionally, the blood coagulation assay device 3 includes a pipette 43a for piercing the stopper attached to the sample container 111 and transferring the sample, and a pipette 43b for dispensing a portion of the sample from the reaction container containing the sample into other reaction containers (see below). Figure 9 The suction tubes of each device are equivalent to the maintenance and management objects mentioned above, and are cleaned as part of maintenance and management.

[0052] The transport device 4 also includes a code reading unit 55, which reads the identification code attached to the sample containers 101 and 111 for individual identification of each sample container. In this embodiment, the code reading unit 55 is provided in the rack mounting unit 5. The rack mounting unit 5 has, for example, a first and a second transport path extending in the front-rear direction that are connected rearward and are generally formed into a U-shape when viewed from above, configured to allow the rack to be mounted in front of the first transport path. The rack mounted in front of the first transport path moves rearward on the first transport path and then moves forward again on the second transport path. The second transport path is connected to the transport path 50, transporting the racks 100 and 110 from the second transport path to the transport path 50.

[0053] The code reading unit 55 reads the identification code of the sample container held on the shelf and moving along the transport path of the shelf setting unit 5. The identification code is, for example, a sample ID, and a barcode label with a printed barcode representing the sample ID is affixed to the sample container. The transport control unit 54 determines the transport destination of the shelf holding the sample container based on the identification code read by the code reading unit 55. As described above, the shelf 100 holding sample container 101 is transported to the blood cell analysis device 2 via the first transport path 51, and the shelf 110 holding sample container 111 is transported to the blood coagulation assay device 3 via the second transport path 52. That is, based on the identification code read by the code reading unit 55, it is determined which of the shelves 100 and 110 it belongs to.

[0054] In the composite analysis system 1, the blood cell analyzer 2 and the blood coagulation assay device 3 are mostly positioned behind the transport path 50, i.e., on the first side of the transport device 4. It should be noted that a portion of the lower part of the blood cell analyzer 2 and the blood coagulation assay device 3 is positioned directly below the transport path 50. In the composite analysis system 1, an operator's standing position is provided on the second side (front) of the transport path 50, and the blood cell analyzer 2 and the blood coagulation assay device 3 are positioned on the first side (rear) of the transport path 50. Furthermore, the parts of the power supply receiver, the terminal device, etc., that are operated by the operator, are positioned facing forward of the composite analysis system 1 so that they can be operated from the second side of the transport path 50.

[0055] The power operation receiving unit includes at least one of a start indication receiving unit for receiving instructions to start the blood cell analyzer 2 and the blood coagulation assay 3, and a stop indication receiving unit for receiving instructions to stop the respective devices. In this embodiment, the blood cell analyzer 2 and the blood coagulation assay 3 are respectively provided with start indication receiving units and stop indication receiving units. Therefore, the operator can start / stop each device individually.

[0056] The blood cell analyzer 2 includes a power button 16a for the analyzer 16 as a start-up indicator receiver. The blood cell analyzer 2 is configured such that if the operator operates the power button 16a, the analyzer 16 starts, and the measurement units 10A and 10B also start. The blood coagulation assay device 3 includes a main power button 35 as a start-up indicator receiver. Both the power button 16a and the main power button 35 are positioned with their operating surfaces facing the front of the composite analysis system 1, allowing operation from the second side of the transport device 4. In other words, the blood cell analyzer 2, the blood coagulation assay device 3, and the transport device 4 are arranged in a position and orientation that allows operation of the start-up indicator receiver from the second side of the transport device 4.

[0057] The operating surface of the power button 16a of the blood cell analyzer 2 is configured facing away from the first side of the transport device 4, i.e., facing away from the transport path 50. In other words, the power button 16a is configured such that its operating surface is parallel to the long side of the transport path 50. In this case, the operability of operating the power button 16a from the front of the transport path 50 is improved. The main power button 35 of the blood coagulation assay device 3 is, for example, a lever switch, but it can also be a push-button switch like the power button 16a. Alternatively, the main power button 35 can also be configured behind the transport path 50, with its operating surface facing away from the transport path 50.

[0058] The terminal device is a device that receives operation instructions and displays information for at least one of the blood cell analysis device 2 and the blood coagulation assay device 3. That is, the terminal device includes at least one of an operation instruction receiving unit and an information display unit. The terminal device broadly includes operation units that are not part of the power operation receiving unit. It should be noted that the present invention does not structurally require a clear distinction between the terminal device and the power operation receiving unit. In this embodiment, the displays 17 and 37, which are touch panels, function as the terminal device for receiving operation instructions and displaying information. Furthermore, the operation buttons of each device correspond to the operation instruction receiving unit of the terminal device.

[0059] The display 17 shows a screen containing an operation instruction receiving unit that receives operation instructions for the blood cell analyzer 2, and the display 37 shows a screen containing an operation instruction receiving unit that receives operation instructions for the blood coagulation assay device 3. Both displays 17 and 37 are configured so that the screens displaying the operation instruction receiving units face forward of the composite analysis system 1, allowing operation from the second side of the transport device 4. In other words, the blood cell analyzer 2, the blood coagulation assay device 3, and the transport device 4 are configured in a position and orientation that allows operation of the displays 17 and 37 from the second side of the transport device 4.

[0060] In the composite analysis system 1, it is preferable to position the working part 2Z of the blood cell analyzer 2 and the working part 3Z of the blood coagulation assay 3 at a horizontal distance of 700 mm from the end of the second side (front) of the transport device 4 towards the first side (rear). In this embodiment, the front end 50a of the transport device 4 is located at the frontmost part of the system, becoming the end of the second side of the transport device 4. That is, it is preferable to position the working parts 2Z and 3Z within a length range of 700 mm in the front-rear direction from the front end 50a of the transport device 4. In this case, good operability is obtained.

[0061] Specifically, the front cover 11a, sample placement section 19, on / off button 20, measurement start button 21, and other operation buttons, power button 16a, and display screen 17 of the blood cell analyzer 2 are preferably arranged within a horizontal distance of 700 mm from the front end 50a of the transport device 4. Similarly, the blood coagulation analyzer 3 preferably has its front cover 31a, sample placement section 49, measurement start button 39, and other operation buttons, main power button 35, and display screen 37 arranged within a horizontal distance of 700 mm from the front end 50a of the transport device 4. Furthermore, the operating surfaces of each button and the displays 17 and 37 are preferably arranged facing away from the first side of the transport device 4, i.e., facing away from the transport path 50.

[0062] Below, further reference Figures 3-8 The blood cell analysis device 2 that constitutes the composite analysis system 1 is described in detail.

[0063] Figure 3 This is a diagram showing the internal structure of the blood cell analyzer 2. (Example) Figure 3 As shown, the blood cell analyzer 2 includes measuring units 10A and 10B, and a transport unit 18 connected to a first transport path 51. The measuring units 10A and 10B and the transport unit 18 are positioned behind the first transport path 51. The measuring units 10A and 10B remove a sample container 101 from a rack 100 on an intermediate transport path 18b leading to the transport unit 18 and insert it into the unit to measure the sample contained in the sample container 101. For example, the measurable items of the measuring units 10A and 10B may be the same for each other. Alternatively, some of the measurable items of the measuring units 10A and 10B may also be different for each other. Figure 3 The internal structure of measuring unit 10A is shown, but measuring unit 10B also has the same device structure.

[0064] The transport unit 18 includes an infeed path 18a for transferring the rack 100 from the first transport path 51, an intermediate transport path 18b, and an outfeed path 18c for transferring the rack 100 out of the first transport path 51, and has a transport path that is generally U-shaped when viewed from above. The intermediate transport path 18b is a transport path that connects the infeed path 18a and the outfeed path 18c, and is arranged parallel to the first transport path 51. An acquisition position P2A for the measurement unit 10A to acquire a sample and an acquisition position P2B for the measurement unit 10B to acquire a sample are set on the intermediate transport path 18b. The intermediate transport path 18b may include, for example, a belt conveyor, configured to allow the rack 100 to move in the left-right direction.

[0065] Measurement unit 10A can, for example, perform CBC and DIFF measurements. CBC measurements include WBC (white blood cell count), RBC (red blood cell count), HGB (hemoglobin level), HCT (hematocrit), MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin level), MCHC (mean corpuscular hemoglobin concentration), and PLT (platelet count). DIFF measurements include NEUT# (neutrophil count), LYMPH# (lymphocyte count), MONO# (monocyte count), EO# (eosinophil count), and BASO# (basophil count). Measurement unit 10B, for example, in addition to CBC and DIFF measurements, can also perform RET, PLT-F, and WPC measurements. RET measurements include RET# (reticulocyte count). PLT-F measurements include PLT# (platelet count).

[0066] The measurement unit 10A includes a container transfer unit 12, a code reading unit 13, a sample preparation unit 14, a measurement unit 15, and a robot arm 26. The robot arm 26 removes the sample container 101 from the rack 100 at the acquisition position P2 on the intermediate transport path 18b, shakes the removed sample container 101 a predetermined number of times to stir it by inversion, and then places it on the container transfer unit 12. The container transfer unit 12 is configured to hold the sample container 101 in an upright state and move the sample container 101 in the front-back direction. The code reading unit 13 is provided on the transport path of the container transfer unit 12 that moves the sample container 101, and reads the sample ID from the label affixed to the sample container 101.

[0067] The operation of measurement units 10A and 10B and transport unit 18 is controlled by the control unit of the analysis device 16. The control unit queries the host 120 for measurement instructions based on the sample ID read by the code reading unit 13, and obtains the sample measurement instructions from the host 120. At this time, the measurement unit to which the sample container 101 is introduced is determined in a load-distribution manner for measurement units 10A and 10B. For example, sample containers 101 with odd-numbered numbers in the holding section of the rack 100 are introduced into measurement unit 10A, and sample containers 101 with even-numbered numbers are introduced into measurement unit 10B.

[0068] The sample preparation unit 14 includes a pipette 14a. The pipette 14a passes through the stopper of the sample container 101 disposed in the container transfer unit 12 and aspirates the sample. When the sample aspiration is completed, the sample container 101 is transported forward by the container transfer unit 12 and returned to its original holding part in the rack 100 by the robot arm 26. The sample preparation unit 14 includes, for example, a reaction chamber and a reagent supply unit 22, and prepares a test sample by mixing the aspirated sample and reagent in the reaction chamber. Multiple reaction chambers are provided according to the type of test, and various reagents (staining solutions, etc.) corresponding to the test item are supplied to each reaction chamber to prepare test samples corresponding to various test items.

[0069] The measurement unit 15 performs RBC and PLT detection using the sheath flow DC detection method, and HGB detection using the SLS-hemoglobin method. Additionally, the measurement unit 15 includes an FCM measurement unit for WBC detection using flow cytometry with a semiconductor laser. The prepared measurement sample is supplied to the FCM measurement unit, etc. The detection results obtained by the measurement unit 15 are sent to the analysis device 16 as sample measurement data.

[0070] The pipette 14a is located inside the housing 11 and can be viewed by opening the front cover 11a. The pipette 14a is a maintenance-managed component that is periodically cleaned or repaired when measurement results are abnormal, such as periodically cleaning the attached sample when measurement results are abnormal. As detailed later, the front cover 11a can be opened from the front of the composite analysis system 1, allowing the operator to clean the pipette 14a from the front of the system. That is, the blood cell analyzer 2 and the transport device 4 are configured to allow operation of the pipette 14a from the second side of the transport device 4, or in other words, the second side of the first transport path 51. The pipette 14a is operated across the first transport path 51 from the second side of the first transport path 51. The pipette 14a is preferably located within a length of 700 mm horizontally from the front end 50a of the transport device 4 in the front-rear direction. In this case, workability is improved.

[0071] Figure 4 This diagram shows the upper part of the blood cell analyzer 2 (measurement unit 10A), indicating the state after the front cover 11a is opened. (See diagram below.) Figure 4 As shown, the blood cell analyzer 2, covered by the front cover 11a, includes a reagent supply section 22 for holding reagents and an anti-backflow chamber 25. The front cover 11a forms part of the front surface of the frame 11 and is configured to open by rotating from bottom to top. The front cover 11a is rotatably fixed to the upper surface of the frame 11 via a hinge.

[0072] A handle 11c is provided at the lower part of the front cover 11a. The handle 11c is an operating part used to open the front cover 11a. The handle 11c is formed, for example, by fixing a component with a recess for inserting a finger to the inner surface of the front cover 11a with the recess facing downward. The handle 11c is provided on the front surface of the front cover 11a opposite to the first transport path 51. Therefore, the operator can easily open the front cover 11a from the front of the composite analysis system 1. The handle 11c is operated by crossing the first transport path 51 from the second side of the first transport path 51.

[0073] The reagent supply unit 22 is located inside the front cover 11a and has a reagent container support 22a that holds multiple reagent containers containing a predetermined amount of reagent. The reagent container support 22a functions as a reagent placement section for holding reagents. A pipette for transferring reagents from the reagent containers is located at the rear of the reagent container support 22a. The reagent container support 22a may include, for example, five support sections, configured to hold five different reagent containers. The reagent containers held on the reagent container support 22a contain reagents (staining solutions) for measuring multiple assays by the FCM assay unit.

[0074] The reagent supply unit 22 is located inside the housing 11 and can be operated by opening the front cover 11a. As described above, the front cover 11a can be opened from the front of the composite analysis system 1, and the reagent supply unit 22 is configured to allow the reagent container to be replaced from the front of the composite analysis system 1. That is, the blood cell analyzer 2 and the transport device 4 are configured in a position and orientation that allows operation of the reagent supply unit 22 from the second side of the first transport path 51. More specifically, the blood cell analyzer 2 and the transport device 4 are configured in a position and orientation that allows the operator to install and remove the reagent container from the reagent container holder 22a from the second side of the first transport path 51. The reagent supply unit 22 is operated across the first transport path 51 from the second side of the first transport path 51. In addition, the reagent supply unit 22 is preferably located within a length range of 700 mm in the front-rear direction from the front end 50a of the transport device 4.

[0075] The anti-backflow chamber 25 is disposed inside the hematology analyzer 2, which is covered by the front cover 11a, and is positioned side-by-side with the reagent supply unit 22 in the left-right direction. The anti-backflow chamber 25 prevents backflow from the reaction chamber to the reagent supply unit 22. The anti-backflow chamber 25 is a maintenance part that is periodically inspected and cleaned when abnormal test results occur, and can be inspected and cleaned from the front of the composite analysis system 1. That is, the hematology analyzer 2 and the transport device 4 are configured in a position and orientation that allows for visual inspection and operation of the anti-backflow chamber 25 from the second side of the first transport path 51. The anti-backflow chamber 25 is operated across the first transport path 51 from the second side of the first transport path 51. The anti-backflow chamber 25 is preferably disposed within a length of 700 mm in the front-rear direction from the front end 50a of the transport path 50.

[0076] Figure 5 This diagram shows the upper part of the blood cell analyzer 2 (measurement unit 10A), illustrating a manual measurement using a precision-controlled substance. It should be noted that the precision-controlled substance is also commonly referred to as a precision-controlled sample. For example... Figure 5 As shown, a sample placement section 19 is provided on the lower part of the front surface of the measuring unit 10A. This sample placement section 19 is configured to hold the cover 19a (see reference 10A) Figure 4 The sample placement section 19 can be opened and pulled forward to accommodate a sample container holding a precision-managed sample. An on / off button 20 and a measurement start button 21 are also provided on the lower part of the front surface of the measurement unit 10A. Operating the on / off button 20 opens and closes the sample placement section 19, and operating the measurement start button 21 begins the measurement of the sample placed in the sample placement section 19. For example, a sample container is placed in the sample placement section 19 when measuring precision-managed or emergency samples, and a cleaning solution container is placed there when cleaning the device.

[0077] The sample placement section 19, the on / off button 20, and the measurement start button 21 are arranged facing away from the first side of the transport device 4, that is, on the front surface of the measurement unit 10A opposite to the first transport path 51, allowing the sample container to be placed in the sample placement section 19 from the front of the composite analysis system 1. Furthermore, the operating surfaces of the on / off button 20 and the measurement start button 21 are arranged facing away from the first transport path 51, allowing for easy operation from the front of the composite analysis system 1. In other words, the blood cell analyzer 2 and the transport device 4 are arranged in a position and orientation that allows operation of the sample placement section 19, the on / off button 20, and the measurement start button 21 from the second side of the first transport path 51. The sample placement section 19, the on / off button 20, and the measurement start button 21 are operated across the first transport path 51 from the second side of the first transport path 51. Additionally, as described above, the sample placement section 19 and each button are preferably located within a length range of 700 mm in the front-rear direction from the front end 50a of the transport device 4.

[0078] The blood cell analyzer 2 includes an error response unit that handles errors that occur within the device. An example of such an error is when the measurement result of a precision-managed sample deviates from the management range. If this error occurs, for example, the precision-managed sample is re-measured, and precision-managed samples from different batches are placed in the sample placement unit 19. Therefore, the sample placement unit 19 functions as the error response unit.

[0079] Figure 6 This diagram shows the lower part of the blood cell analyzer 2, indicating the state after door 24 is opened. (Example) Figure 6 As shown, a cleaning solution placement section 23 is provided at the lower part of the blood cell analyzer 2, which holds a cleaning solution container 23a. The cleaning solution container 23a contains cleaning solution used for cleaning the device. The cleaning solution placement section 23 may have a space for holding the cleaning solution container 23a, or it may be configured with a drawer, shelf, base, etc., to hold the cleaning solution container 23a. A door 24 is provided at the lower part of the blood cell analyzer 2, forming the front surface of the device, and closes the cleaning solution placement section 23.

[0080] The cleaning solution placement section 23 is located below the measurement units 10A and 10B and the transport path 50, and the cleaning solution container 23a can be removed / placed by opening the door 24 from the front of the composite analysis system 1. That is, the blood cell analyzer 2 and the transport device 4 are positioned to allow operation of the cleaning solution placement section 23 from the second side of the first transport path 51. For example, the left end of the door 24 is hinged to the lower side of the frame 11 and can be opened by rotating from right to left. The cleaning solution placement section 23 is located on the first side of the transport device 4 and is configured to move to the second side of the transport device 4. For example, the drawer, base, etc., constituting the cleaning solution placement section 23 can be pulled out to the second side of the transport device 4, allowing the cleaning solution container 23a to be removed / placed from the second side.

[0081] Figure 7 This is an example diagram showing the operation screen of the blood cell analyzer 2. (Example) Figure 7 As shown, the operation screen 200 includes: a toolbar 210 containing main function buttons; a status display area 220 containing indicators showing the status of the device, the status of the main unit, and the remaining levels of reagents, consumables, etc.; and a menu icon display area 230. The operation screen 200 is displayed on the monitor 17. In addition to the operation screen 200, the monitor 17 also outputs a command screen for inputting sample information during manual measurement, a precision management screen containing information related to precision management, and a results display screen described later.

[0082] Toolbar 210 includes a menu button 211, a QC document button 212 for displaying the accuracy management screen, and a measurement registration button 213 for displaying the instruction screen. The menu icon display area 230 displays multiple buttons (icons) for various operations and information display; it may also display buttons identical to those included in the toolbar 210. The menu icon display area 230 includes an exit button 231, a close button 232, a history button 233, a calibration history button 234, a measurement section setting button 235, and a schedule setting button 236.

[0083] The off button 232 displayed on the operation screen 200 corresponds to the off instruction receiving unit that receives instructions to turn off the blood cell analyzer 2. Additionally, the operation buttons other than the off button 232 correspond to operation instruction receiving units that receive operation instructions for the blood cell analyzer 2. The screen of the display 17 is a touch panel screen that receives operation instructions and displays information, and is configured in an orientation opposite to the first transport path 51. That is, the screen of the display 17 faces the front of the composite analysis system 1, and the blood cell analyzer 2 and transport device 4 are configured in a position and orientation that allows operation of the off button 232 and various operation buttons from the second side of the first transport path 51. The screen of the display 17 is operated across the first transport path 51 from the second side of the first transport path 51.

[0084] Figure 8 This is an example diagram showing the results displayed by the blood cell analyzer 2. (Example) Figure 8 As shown, in addition to the blood sample number and the date and time of the test, the results display screen also includes areas 61-64. Area 61 displays the number of neutrophils (NEUT), lymphocytes (LYMPH), monocytes (MONO), eosinophils (EO), and basophils (BASO), and their respective proportions relative to the white blood cell count, along with the total white blood cell (WBC) count. Area 62 displays the test results for the examined items. Area 63 displays marker information indicating suspected presence of specified abnormal cells in the blood sample. Area 64 displays a scatter plot. This scatter plot is a two-dimensional scatter plot with the horizontal axis set to lateral scattering intensity and the vertical axis set to fluorescence intensity. The results display screen is shown on monitor 17. It should be noted that output to monitor 17 is also possible. Figure 8 Other result display screens besides the example result display screen.

[0085] The result display screen on the display 17 is equivalent to the analysis result display unit that displays the analysis results of the blood cell analyzer 2. The screen of the display 17 is configured in an orientation opposite to the first transport path 51, i.e., facing forward of the composite analysis system 1. The blood cell analyzer 2 and the transport device 4 are configured in a position and orientation that allows the analysis results displayed on the analysis result display unit to be viewed from the second side of the first transport path 51.

[0086] Below, further reference Figures 9-13 The blood coagulation assay device 3, which constitutes the composite analysis system 1, will be described in detail. The blood coagulation assay device 3 is, for example, a device for analyzing blood coagulation function by coagulation method, synthetic matrix method, immunoturbidimetric method and agglutination method. The structure of the device will be described below using the coagulation method as an example.

[0087] Figure 9This is a diagram showing the internal structure of the blood coagulation measuring device 3. (Example) Figure 9 As shown, the blood coagulation assay apparatus 3 includes a assay sample preparation unit 33 for preparing an assay sample containing a sample and reagents, and a measurement unit 34 for performing optical measurements on the assay sample. The assay sample is prepared, for example, by mixing coagulation assay reagents such as prothrombin time (PT) assay reagent and activated partial prothrombin time (APTT) assay reagent into the sample, and then mixing in reagents such as calcium solution to initiate blood coagulation. The measurement unit 34 measures the optical information of the prepared assay sample.

[0088] The sample is prepared by centrifuging a whole blood sample collected from the subject. For example, the sample may be the supernatant obtained by centrifuging blood with added anticoagulant. A sample container 111 containing the sample is placed on a rack 110.

[0089] For coagulation assays, any APTT assay reagent will suffice; it must contain an activator and phospholipids. Commercially available reagents such as Revohem APTT SLA (Sysmex Corporation), ThromboCheck APTT SLA (Sysmex Corporation), COAGPIA APTT-N (Sekisui Medical Co., Ltd.), and Datafi APTT (Siemens Healthcare Diagnostics Products GmbH) can be used.

[0090] The sample preparation unit 33 has a reagent holding platform 32a. The reagent holding platform 32a is a circular platform. The reagent holding platform 32a is equivalent to a reagent placement section for placing reagents. On the reagent holding platform 32a, a plurality of container racks 47a and 47b are arranged along the circumference of the platform. Reagent containers 48b, 48c, 48d, etc., containing solutions containing reagents are placed on the container racks 47a and 47b. The reagent containers 48b, 48c, 48d, etc., are, for example, solidified test reagents or calcium solutions. The reagent containers 48b, 48c, 48d, etc., are placed on the container racks 47a and 47b by the operator in a state where they are removed from the reagent holding platform 32a. The placement of the container racks 47a and 47b, containing the reagent containers 48b, 48c, 48d, etc., onto the reagent holding platform 32a is performed by the operator with the front cover 31a open, thus opening the interior of the device.

[0091] The reagent holding stage 32a includes a first stage 32b in a top-view circular shape and a second stage 32c in a top-view annular shape disposed on the outer periphery of the first stage 32b. Figure 9In the example shown, four container racks 47a are arranged circumferentially on the first unit 32b. Three large container racks 47b are arranged circumferentially on the second unit 32c. The first unit 32b and the second unit 32c can rotate independently circumferentially around the rotation axis 32d via a rotating mechanism equipped with an electric motor. By rotating, reagent containers 48b, 48c, 48d, etc., can be moved to designated positions. When changing reagent containers 48b, 48c, 48d, etc., the first unit 32b or the second unit 32c rotates, and the reagent containers 48b, 48c, 48d, etc., to be replaced stop at an angular position on the front side of the system. Thus, the operator can operate the reagent placement table 32a from the second side of the transport device 4, that is, from the second side of the second transport path 52, i.e., install and remove the container racks 47a, 47b containing the reagents to be replaced from the reagent holding table 32a. The reagent holding table 32a is operated across the second transport path 52 from the second side of the second transport path 52.

[0092] The sample preparation unit 33 is equipped with a code reading unit 32e that reads the identification codes assigned to reagent containers 48b, 48c, 48d, etc., and container racks 47a, 47b, etc. By reading the identification codes by the code reading unit 32e, the positions of the reagent containers 48b, 48c, 48d, etc. on the reagent holding station 32a can be determined.

[0093] The sample preparation unit 33 includes first dispensing units 42a and 42b for dispensing samples. Each of the first dispensing units 42a and 42b has a dispensing arm that holds the dispensing pipettes 43a and 43b in a rotatable manner. The pipettes 43a and 43b are configured to aspirate and dispense a predetermined amount of fluid. The tip of the pipette 43a is sharpened to pierce a stopper attached to the opening of the sample container 111. The first dispensing unit 42a moves the pipette 43a onto the sample container 111, aspirates a predetermined amount of sample from the sample container 111, and dispenses the predetermined amount of sample into the reaction container 48a. The first dispensing unit 42b moves the pipette 43b onto the reaction container 48a containing the sample, aspirates a portion of the sample from the reaction container 48a, and dispenses a portion of the sample into other reaction containers 48a. In the case of multiple measurement items, the first dispensing unit 42b moves the pipette 43b to the reaction container 48a containing the sample and pipettes a portion of the sample from the reaction container 48a again, and further dispenses a portion of the sample into other reaction containers 48a.

[0094] The transport unit 38 positions the sample container 111 held on the rack 110 at a designated sample aspiration position P3a. The sample aspiration position P3a is the sample acquisition position P3 of the blood coagulation assay device 3. The transport unit 38 has a code reading unit 41 that reads the sample ID from a label affixed to the sample container 111. The operation of the device body 30 and the transport unit 38 is controlled by the control unit of the analysis device 36. Based on the sample ID read by the code reading unit 41, the control unit queries the host 120 for the measurement command and obtains the sample measurement command from the host 120.

[0095] The transport unit 38 includes an infeed path 38a for transferring the rack 110 from the second transport path 52, an intermediate transport path 38b, and an outfeed path 38c for transferring the rack 110 out of the second transport path 52, and has a transport path that is generally U-shaped when viewed from above. The intermediate transport path 38b is the transport path connecting the infeed path 38a and the outfeed path 38c, and is arranged parallel to the second transport path 52. In this embodiment, a sample suction position P3a is set on the intermediate transport path 38b. The intermediate transport path 38b is, for example, a belt conveyor, configured to allow the rack 110 to move in the left-right direction.

[0096] The blood coagulation assay device 3 may also have a sample container fixing part, which fixes the sample container 111 at the sample aspiration position P3a located in the intermediate transport path 38b when the aspiration tube 43a pierces the stopper of the sample container 111 and aspirates the sample. In this case, the sample can be stably collected from the sample container 111 located in the intermediate transport path 38b. It should be noted that the sample container fixing part can also fix the sample container 111 held on the frame 110 by fixing the frame 110.

[0097] The sample preparation unit 33 has a rotating stage 33a for transporting the reaction vessel 48a. The rotating stage 33a is positioned outside the reagent holding stage 32a. The rotating stage 33a has a ring shape when viewed from above and can rotate circumferentially. A plurality of holding holes 33b are provided on the rotating stage 33a arranged circumferentially. Each holding hole 33b can hold the reaction vessel 48a individually.

[0098] The sample is dispensed into the reaction vessel 48a via the first dispensing sections 42a and 42b. As described above, the first dispensing section 42a moves the pipette 43a to dispense a predetermined amount of sample from the sample container 111 located at the sample dispensing position P3a in the transport unit 38. The first dispensing section 42b moves the pipette 43b to dispense a portion of the sample from the reaction vessel 48a containing the sample and dispenses it into other reaction vessels 48a.

[0099] The sample preparation unit 33 includes a holding mechanism 33c capable of transporting the reaction vessel 48a and a heating stage 33e for holding and heating the reaction vessel 48a. The holding mechanism 33c holds and transfers the reaction vessel 48a. The holding mechanism 33c positions the empty reaction vessel 48a in the holding hole 33b of the rotating stage 33a.

[0100] The sample preparation unit 33 has two second dispensing units 33h. Each second dispensing unit 33h has a dispensing pipette 33i. The second dispensing unit 33h moves the pipette 33i to the reagent containers 48b, 48c, 48d, etc., located at designated reagent dispensing positions P34 and P35 on the reagent holding stage 32a, and dispenses a predetermined amount of solidification assay reagent from the reagent containers 48b, 48c, 48d, etc. Then, the second dispensing unit 33h moves to the reaction vessel 48a located on the rotating stage 33a and dispenses the dispensed predetermined amount of solidification assay reagent into the reaction vessel 48a containing the sample.

[0101] The heating stage 33e is a circular stage with a built-in heater. It includes multiple holding holes 33f for holding multiple reaction vessels 48a containing a mixture of sample and coagulation assay reagent, and a holding mechanism 33g for holding and transferring the reaction vessels 48a. Multiple holding holes 33f are arranged circumferentially along the heating stage 33e. The heating stage 33e is circumferentially rotatable, and while heating the reaction vessels 48a to a specified temperature by the heater, it transfers the reaction vessels 48a disposed in the multiple holding holes 33f circumferentially by rotation. The holding mechanism 33g removes the reaction vessel 48a containing the coagulation assay reagent from the holding hole 33b of the rotating stage 33a and places the reaction vessel 48a into any of the holding holes 33f.

[0102] The sample preparation unit 33 also includes a holding mechanism 33d for transferring the reaction vessel 48a. The holding mechanism 33d has a moving mechanism that moves in orthogonal triaxial directions, namely the X, Y, and Z directions, and holds and transfers the reaction vessel 48a. After the mixture in the reaction vessel 48a is heated for a predetermined time by the heating stage 33e, the holding mechanism 33d holds the reaction vessel 48a and positions it at any of the reagent dispensing positions P32 or P33. The second dispensing unit 33h moves the pipette 33i to the reagent containers 48b, 48c, 48d, etc., positioned at the predetermined reagent dispensing positions P34 and P35 on the reagent holding stage 32a, and dispenses a predetermined amount of calcium solution from the reagent containers 48b, 48c, 48d, etc. Next, the second dispensing unit 33h moves to the reaction vessel 48a, which is located at reagent dispensing positions P32 and P33 and contains the heated mixture, and dispenses a predetermined amount of calcium solution into the reaction vessel 48a containing the mixture. As a result, the blood begins to coagulate inside the reaction vessel 48a. The holding mechanism 33d moves the reaction vessel 48a containing the calcium solution to the measuring unit 34. Furthermore, the holding mechanism 33d moves the completed reaction vessel 48a from the container placement unit 34a to the waste outlet 33j.

[0103] The measuring unit 34 measures the absorbance or transmittance of the test sample. The measuring unit 34 includes a container placement section 34a for holding the reaction vessel 48a containing the test sample, a light-transmitting section 34b for irradiating the reaction vessel 48a with light for signal detection, and a light-receiving section 34c disposed opposite to the light-transmitting section 34b across the reaction vessel 48a. Multiple container placement sections 34a are provided in the measuring unit 34. In this case, test samples in multiple reaction vessels 48a can be measured simultaneously.

[0104] The measuring unit 34 measures the time-dependent change in transmitted light during the reaction process of the hemostatic component in the test sample disposed within the container 48a of the container placement unit 34a. The light-emitting unit 34b irradiates the test sample disposed within the reaction container 48a of the container placement unit 34a with light. The light-emitting unit 34b includes a light source such as a light-emitting diode or a halogen lamp. The light-receiving unit 34c receives light (transmitted light) that irradiates and transmits through the test sample within the reaction container 48a, and outputs an electrical signal corresponding to the amount of light received. The light-receiving unit 34c includes a photoelectric conversion element that converts the received light into an electrical signal and outputs it, sending the electrical signal to the analysis device 36. It should be noted that the measuring unit 34 may also be configured to receive light (scattered light) formed by the light irradiated from the light-emitting unit 34b and scattered by the test sample through the light-receiving unit 34c.

[0105] The analysis device 36 analyzes the solidification time, activity of a specified component, and concentration of a specified component based on the measurement results of the electrical signal output from the light-receiving unit 34c, i.e., the optical information of the sample acquired by the measuring unit 34. For example, the analysis device 36 generates a reaction curve and calculates the solidification time based on the intensity of light transmitted through the test sample. The analysis results of the analysis device 36 are displayed on the display 37.

[0106] Figure 10 This diagram shows the upper part of the blood coagulation measuring device 3, indicating the state after the front cover 31a is opened. (See diagram below.) Figure 10 As shown, the blood coagulation assay device 3, covered by the front cover 31a, includes a first dispensing section 42a, 42b with pipettes 43a, 43b for transferring samples from the sample container 111, and a cooling section 40 for holding reagents. The front cover 31a forms the front surface of the frame 31, the front portion of the upper surface, and the front portion of the left side, and is configured to open by rotating from bottom to top.

[0107] The front cover 31a is rotatably fixed to the rear portion of the upper surface of the frame 31 via a hinge. Additionally, a handle 31c is provided on the lower part of the front surface of the front cover 31a. The handle 31c is an operating part used to open the front cover 31a. The handle 31c has a recess for inserting a finger from below and is provided on the front surface of the front cover 31a opposite to the second transport path 52. Therefore, the operator can easily open the front cover 31a from the front of the composite analysis system 1. The handle 31c is operated by crossing the second transport path 52 from its second side.

[0108] Two pipettes 43a and 43b are installed inside the blood coagulation assay device 3. These pipettes 43a and 43b can be viewed by opening the front cover 31a. The pipettes 43a and 43b are maintenance items that are cleaned periodically or when abnormal measurement results occur. The operator can clean them from the front of the composite analysis system 1. That is, the blood coagulation assay device 3 and the transport device 4 are configured in a position and orientation that allows operation of the pipettes 43a and 43b from the second side of the second transport path 52. The pipettes 43a and 43b are operated across the second transport path 52 from the second side.

[0109] The cooling section 40 has a reagent holding platform 32a that is cooled to a temperature suitable for storing reagents and on which reagents are placed. Reagent containers 48b, 48c, 48d, etc., are placed on the reagent holding platform 32a as described above. The cooling section 40 has an opening 40a for removing / placing container racks 47a, 47b, and a cooling section cover 40b for opening and closing the opening 40a. The cooling section cover 40b is configured to open by rotating in the same direction as the front cover 31a.

[0110] The reagent holding platform 32a of the cooling section 40 serves as both a reagent placement area for the blood coagulation assay device 3 and a precision management sample placement area for precision management samples. The operator can place reagents, precision management samples, etc., onto the reagent holding platform 32a by opening the front cover 31a and the cooling section cover 40b from the front of the composite analysis system 1. That is, the blood coagulation assay device 3 and the transport device 4 are configured in a position and orientation that allows operation of the reagent holding platform 32a from the second side of the second transport path 52. Furthermore, the reagent holding platform 32a and the two pipettes 43a and 43b are preferably located within a horizontal distance of 700 mm from the front end 50a of the transport device 4 in the front-to-back direction. This improves workability.

[0111] The blood coagulation assay device 3, as described above, includes a sample placement section 49 located adjacent to the second transport path 52. A sample container is placed on the sample placement section 49, for example, in cases of measuring samples requiring precision management or in emergency situations. Measurement of the sample placed on the sample placement section 49 is initiated by operating the measurement start button 39 located on the front surface of the blood coagulation assay device 3. The sample placement section 49 is configured with an orientation opposite to the first side of the transport device 4, i.e., opposite to the second transport path 52, allowing the sample container to be placed in the sample placement section 49 from the front of the composite analysis system 1. In other words, the blood coagulation assay device 3 and the transport device 4 are configured in a position and orientation that allows operation of the sample placement section 49 from the second side of the second transport path 52. The sample placement section 49 is operated across the second transport path 52 from its second side.

[0112] The blood coagulation assay device 3 includes an error response unit to handle errors that occur within the device. As an example of an error, similar to the case of the blood cell analyzer 2, an error could be made where the measurement result of a precision-managed sample deviates from the management range. If this error occurs, for example, the precision-managed sample is re-measured, and precision-managed samples from different batches are placed on the sample placement unit 49. Therefore, the sample placement unit 49 functions as the error response unit.

[0113] Figure 11 This diagram shows the lower part of the blood coagulation measuring device 3, indicating the state after the door 45 is opened. (Example) Figure 11As shown, a cleaning solution placement section 44 is provided at the lower part of the blood coagulation testing device 3, containing a cleaning solution container 44a. The cleaning solution container 44a holds the cleaning solution used for cleaning the blood coagulation testing device 3. The cleaning solution placement section 44 may have a space capable of holding the cleaning solution container 44a, or it may be configured with a drawer, shelf, base, or similar fixture for holding the cleaning solution container 44a. A door 45 is provided at the lower part of the blood coagulation testing device 3, forming the front surface of the device, and closes the cleaning solution placement section 44.

[0114] The cleaning fluid placement section 44 is located below the main body 30 and the transport path 50. The cleaning fluid container 44a can be removed / placed by opening the door 45 from the front of the composite analysis system 1. That is, the blood coagulation assay device 3 and the transport device 4 are positioned to allow operation of the cleaning fluid placement section 44 from the second side of the second transport path 52. For example, the left end of the door 45 is hinged to the lower side of the frame 31 and can be opened by rotating from right to left. The cleaning fluid placement section 44 is located on the first side of the transport device 4 and is configured to be movable to the second side of the transport device 4. For example, the drawer, base, etc., constituting the cleaning fluid placement section 44 can be pulled out to the second side of the transport device 4, allowing the cleaning fluid container 44a to be removed / placed from the second side.

[0115] The blood coagulation assay device 3 includes an anti-backflow chamber 46. The anti-backflow chamber 46 is a maintenance component that is periodically inspected, cleaned, or repaired when measurement results are abnormal. In this embodiment, the anti-backflow chamber 46 is provided inside the device, covered by a door 45, at the lower part of the blood coagulation assay device 3. The anti-backflow chamber 46 can be inspected by opening the door 45 and can be easily removed from the front of the composite analysis system 1. That is, the blood coagulation assay device 3 and the transport device 4 are configured in a position and orientation that allows operation of the anti-backflow chamber 46 from the second side of the second transport path 52. Furthermore, the anti-backflow chamber 46 is preferably located within a horizontal distance of 700 mm from the front end 50a of the transport device 4 in the front-rear direction.

[0116] Figure 12 This is an example diagram showing the operation screen of the blood coagulation measuring device 3. (Example) Figure 12 As shown, the operation screen 300 includes: a toolbar 310 containing buttons for main functions; a status display area 320 containing indicators showing the status of the device, the status of the main unit, and the remaining levels of reagents, consumables, etc.; and a menu icon display area 330. The operation screen 300 is displayed on the monitor 37. In addition to the operation screen 300, the monitor 37 also outputs a command screen for inputting sample information during manual measurement, a result display screen (described later), etc.

[0117] Toolbar 310 includes a maintenance button 311 for operating during device maintenance, a shut-off button 312 for shutting down the device, and an instruction button 313 for displaying the instruction screen. The menu icon display area 330 displays multiple buttons (icons) for various operations and information display; it may also display buttons identical to those included in the toolbar 310. The menu icon display area 330 includes a reagent consumables button 331, a measurement line button 332, a QC chart button 333, a maintenance button 334, an error history button 335, a setting button 336, and a shut-off button 337.

[0118] The off buttons 312 and 337 displayed on the operation screen 300 correspond to the off instruction receiving units that receive instructions to turn off the blood coagulation measuring device 3. Additionally, the operation buttons other than off buttons 312 and 337 correspond to operation instruction receiving units that receive operation instructions for the blood coagulation measuring device 3. The screen of the display 37 is a touch panel screen that receives operation instructions and displays information as described above, and is configured with an orientation opposite to the second transport path 52. If the touch panel screen detects contact with the operator's finger, each button receives an operation instruction. That is, the screen of the display 37 faces forward of the composite analysis system 1, and the blood coagulation measuring device 3 and the transport device 4 are configured in a position and orientation that allows operation of the off buttons 312 and 337 and various operation buttons from the second side of the second transport path 52. The screen of the display 37 is operated across the second transport path 52 from the second side of the second transport path 52.

[0119] Figure 13 This is an example diagram showing the result display screen of the blood coagulation testing device 3. (Example) Figure 13 As shown, the results display screen 350 includes a reaction curve display area 351 that displays a reaction curve representing the time-series change in the intensity of transmitted light, and is a screen that displays details of the results of the measurement item selected by the measurement item label 352. The results display screen 350 is displayed on the monitor 37. It should be noted that other results display screens besides the results display screen 350 can also be output to the monitor 37.

[0120] The results display screen 350 also includes a measurement results display area 353a, a detailed information display area 353b, and an error information display area 354. Figure 13 In the example shown, the measurement item "PT" is selected, and the measurement results related to this measurement item are displayed in the measurement result display area 353a and the detailed information display area 353b.

[0121] The result display screen 350 on the display 37 corresponds to the analysis result display unit that displays the analysis results of the blood coagulation assay device 3. The screen of the display 37 is configured in an orientation opposite to the second transport path 52, i.e., facing forward of the composite analysis system 1. The blood coagulation assay device 3 and the transport device 4 are configured in a position and orientation that allows the analysis results displayed on the analysis result display unit to be viewed from the second side of the second transport path 52.

[0122] Below, refer to Figures 14-17 Other examples (modifications) of the embodiments will be described. The same reference numerals are used for the same components as in the embodiments described above, and repeated descriptions are omitted.

[0123] Figure 14 This is a diagram representing the composite analysis system 1A as the first variant example. (See diagram for example.) Figure 14 As shown, the combined analysis system 1A includes a shared terminal device 500 that can be used for both the blood cell analyzer 2 and the blood coagulation assay 3. The terminal device 500 is, for example, a touch panel display. An operation screen and a measurement result screen are displayed on the screen of the terminal device 500. The operation screen is a shared operation instruction receiving unit that receives operation instructions from both the blood cell analyzer 2 and the blood coagulation assay 3. The measurement result screen is a shared analysis result display unit that displays the analysis results from both the blood cell analyzer 2 and the blood coagulation assay 3.

[0124] exist Figure 14 In the example shown, a terminal device 500 is disposed between the blood cell analyzer 2 and the rack return unit 6A. However, the terminal device 500 can be disposed in any location, such as between the rack placement unit 5 and the blood cell analyzer 2, between the rack placement unit 5 and the blood coagulation assay unit 3, or between the blood coagulation assay unit 3 and the rack return unit 6B. Preferably, the screen of the terminal device 500 is positioned facing forward of the composite analysis system 1A, similar to the case of the composite analysis system 1. The terminal device 500 and the transport device 4 are configured to allow operation of the screen from the second side of the transport path 50, and to allow viewing of the measurement results screen, in terms of both position and orientation.

[0125] On the screen of the terminal device 500, at least one of a shared start indication receiver for receiving the start of the blood cell analyzer 2 and the blood coagulation assay 3, and a shared stop indication receiver for receiving the stop of the blood cell analyzer 2 and the stop of the blood coagulation assay 3, may be displayed. Alternatively, the shared start indication receiver may be located in a location other than a push-button or lever switch. However, it is preferable that the switch, like in the case of the composite analysis system 1, be configured to face forward towards the composite analysis system 1A.

[0126] Figure 15 This is a diagram representing the composite analysis system 1B as a second variation. (See diagram below.) Figure 15 As shown, the composite analysis system 1B includes a transport device 4B comprising a main transport path that bends midway. A first transport path 51, which transports the rack 100 from the rack mounting section 5 to the blood cell analyzer 2, extends straight in the left-right direction, but a second transport path 52B, which transports the rack 110 from the rack mounting section 5 to the blood coagulation assay device 3, bends at a right angle midway. The transport path 50B, comprising the straight first transport path 51 and the bend-midway second transport path 52B, serves as the main transport path connecting the rack mounting section 5 and the rack return section. In the composite analysis system 1B, the first transport path 51 and the second transport path 52B are arranged in mutually intersecting directions. The blood cell analyzer 2 and the blood coagulation assay device 3 are arranged with different orientations, allowing the operator to operate and perform tasks on each device from the second side of the transport path 50B, avoiding inefficient actions such as moving around the system as in the past. Furthermore, since the transport path 50B bends midway, the composite analysis system 1B can be configured along two adjacent side walls of the room where the composite analysis system 1B is installed.

[0127] exist Figure 15 In the example shown, the second transport path 52B bends between the shelf mounting section 5 and the blood coagulation measuring device 3A. However, the second transport path 52B may also bend between the blood coagulation measuring device 3A and the blood coagulation measuring device 3B, or between the blood coagulation measuring device 3B and the shelf recovery section 6B. In either case, for example, the following state is achieved: from the shelf mounting section 5 to the bend of the second transport path 52B, the long side direction of the shelf 110 is aligned with the transport direction; from the bend to the shelf recovery section 6B, the long side direction of the shelf 110 is orthogonal to the transport direction. It should be noted that, in addition to the bend of the second transport path 52B, or in place of the bend, a bend may also exist on the first transport path 51.

[0128] Figure 16 This is a diagram representing the composite analysis system 1C as a third variation. (See diagram below.) Figure 16As shown, the composite analysis system 1C differs from other embodiments in that it includes one hematology analyzer 2 and one blood coagulation assay 3. Furthermore, the transport device 4C of the composite analysis system 1C does not include secondary transport paths, i.e., transport units 18 and 38, corresponding to each device. When there is only one hematology analyzer 2, for example, if the measurement time cannot be shortened by transport unit 18, a sample acquisition position P2 for the hematology analyzer 2 is set on the first transport path 51, which is the main transport path. Similarly, when there is only one blood coagulation assay 3, a sample acquisition position P3 for the blood coagulation assay 3 is set on the second transport path 52.

[0129] Figure 17 This is a diagram representing the composite analysis system 1D as the fourth variation. (See diagram for example.) Figure 17 As shown, the composite analysis system 1D differs from other embodiments in that it has adjacent arrangement of the rack recovery sections 6A and 6B and includes a conveying device 4D containing a third conveying path 502. Figure 17 In the example shown, rack recovery units 6A and 6B are located on the right side of the blood cell analyzer 2, and the third transport path 502 extends parallel to the first transport path 51 and the second transport path 52.

[0130] Similar to the other embodiments described above, the first transport path 51 connects the rack placement section 5 and the rack collection section 6A, transporting the rack 100 to the rack collection section 6A via the blood cell analyzer 2. On the other hand, the second transport path 52 connects to the rack collection section 6B via the third transport path 502. In the composite analysis system 1D, the rack 110, transported to the blood coagulation assay device 3 via the second transport path 52, is transported to the rack collection section 6B via the third transport path 502.

[0131] As described above, according to the composite analysis systems 1-1D, each device can be operated and performed from the second side of the transport device. That is, it is not necessary to go around to the first side of the transport device to operate and perform the work on each device. As a result, the operator's travel distance can be significantly reduced, and the operator's workload can be reduced. In addition, since it is not necessary to ensure space for the operator to move to the first side of the transport device, the space required around the composite analysis systems 1-1E can be reduced, and the space of the inspection room can be used efficiently and effectively.

[0132] It should be noted that the above embodiments can be appropriately modified without compromising the purpose of the present invention. For example, in the above embodiments, since the blood cell analysis device 2 and the blood coagulation determination device 3 are respectively arranged on the left and right sides of the shelf mounting section 5, it is necessary to prepare a shelf 100 that holds only sample container 101 and a shelf 110 that holds only sample container 111. However, when the shelf mounting section, the blood cell analysis device and the blood coagulation determination device are arranged side by side along the main transport path, for example, both types of sample containers 101 and 111 can be arranged on the same shelf.

[0133] Explanation of reference numerals in the attached figures 1. Composite Analysis System 2. 2A and 2B blood cell analysis devices 3. 3A, 3B Blood Coagulation Measurement Device 4. Conveying device 5-unit installation department 6A and 6B Recycling Section 10A and 10B measurement units 11 frames 11a front cover 11b side frame 11c handle 12Container transfer department 13 Code Reading Department 14 Sample Preparation Section 14a pipette 15 Measurement Department 16 analytical devices 16A power button 17-inch monitor 18 transport units 18a Moving Path 18b Intermediate transport route 18c moving path 19 Sample Placement Section 19a cover 20 On / Off Buttons 21 Measurement Start Button 22 Reagent Supply Department 22a Reagent Container Holder 23 Cleaning fluid placement section 23a cleaning fluid container 24 doors 25 anti-backflow chamber 26 robotic arms 30 main body of the device 31 frame 31a front cover 31b side frame 31c handle 32. Preparation of dilution reagent solution 32a Reagent Holding Stand The first 32b 32C second unit 32d Rotation Axis 32e code reading unit 33 Sample Preparation Section 33a Rotary Table 33b, 33f retaining holes 33c, 33d, 33g control mechanisms 33e heating table 33h Second Packaging Section 33i pipette 33j abandoned port 34 Measurement Department 34a Container Configuration Department 34b Light Transmission Section 34c light-receiving part 35 Main Power Button 36 analytical devices 37-inch monitor 38 transport units 38a Moving Path 38b intermediate transport path 38c moving path 39. Measurement Start Button 40Cooling Department 40a opening 40b Cold Insulation Cover 41 Code Reading Department 42a, 42b First Packaging Section 43a, 43b pipettes 44 Cleaning fluid placement section 44a cleaning fluid container 45 doors 46 Anti-backflow chamber 47a, 47b container racks 48a Reaction Vessel 48b Reagent Container 48c reagent container 48d reagent container 49 Sample Placement Section 50 delivery routes 51 First Transportation Route 52 Second Delivery Route 54 Transport Control Department 55 Code Reading Department 100, 110 Sample containers 101 and 111 120 host 200 operation screens 210 Toolbar 211 Menu button 212QC file button 213 Measurement Registration Button 220 Status Display Area 230 Menu icon display area 231 Exit button 232 Close button 233 History Button 234 Correction History Button 235 Measurement Section Setting Button 236 Schedule setting button 300 operation screen 310 Toolbar 311 Maintenance Button 312 Close button 313 Command Button 320 Status Display Area 330 Menu icon display area 331 Reagent Consumables Button 332 Measurement Line Button 333QC diagram button 334 Maintenance Button 335 Error History Button 336 Setting Button 337 Close button 350 Results Display Screen 351 reaction curve display area 352 Test Item Label 353a measurement results show the area 353b Detailed Information Display Area 354 error message display area 500 terminal device 501 aircraft installation department 502 Third Transportation Route Get the position of P2, P2A, P2B, and P3. P3a sample aspiration position Sample dispensing locations for P30 and P31 P32, P33 Reagent dispensing locations P34, P35 Reagent Absorption Positions

Claims

1. A composite analysis system, comprising: Blood cell analysis device; Blood coagulation assay device; as well as A transport device, capable of transporting the sample to a first acquisition position of the blood cell analysis device and a second acquisition position of the sample of the blood coagulation assay device, has a first side and a second side opposite to the first side. The blood cell analysis device and the blood coagulation assay device are arranged along the first side of the transport device. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation capable of performing at least one of the following operations: (a) Operation of the power operation receiving unit from the second side of the transport device, the power operation receiving unit receiving power operation of the blood cell analysis device and the blood coagulation assay device; (b) Operation of the consumable placement section from the second side of the transport device, the consumable placement section being used to place consumables used in the blood cell analysis device and consumables used in the blood coagulation assay device; (c) Operation of the terminal device from the second side of the transport device, wherein the terminal device performs at least one of receiving operation instructions and displaying information for the blood cell analysis device, and at least one of receiving operation instructions and displaying information for the blood coagulation assay device; as well as (d) Operation of the maintenance management object unit from the second side of the transport device, wherein the maintenance management object unit performs maintenance management of the blood cell analysis device and the blood coagulation determination device.

2. The composite analysis system according to claim 1, wherein, At least one of the power operation receiving unit, the consumable placement unit, the terminal device, and the maintenance management object unit is disposed on the first side of the transport device and is operated across the transport device from the second side of the transport device.

3. The composite analysis system according to claim 2, wherein, At least one of the power operation receiving unit, the consumable placement unit, the terminal device, and the maintenance management object unit, which are operated across the second side of the transport device, is configured such that the shortest distance from the end of the second side of the transport device is within a length range of 700 mm in horizontal distance.

4. The composite analysis system according to claim 1, wherein, At least one of the power operation receiving unit, the consumable placement unit, the terminal device, and the maintenance management object unit is disposed on the first side of the transport device, and is moved to the second side of the transport device for operation.

5. The composite analysis system according to claim 1, wherein, The conveying device has a main conveying path that extends straight without bending in the middle. The blood cell analysis device and the blood coagulation assay device are configured to face the same direction as each other.

6. The composite analysis system according to claim 1, wherein, The conveying device has a main conveying path that bends midway. The blood cell analysis device and the blood coagulation determination device are configured with different orientations.

7. The composite analysis system according to claim 1, wherein, The blood cell analysis device has a first aspiration tube that pierces the stopper attached to the first sample container and aspirates the sample. The blood coagulation assay device has a second suction tube that pierces a stopper attached to a second sample container and aspirates the sample.

8. The composite analysis system according to claim 7, wherein, The blood coagulation assay device has a sample container fixing part, which fixes the second sample container at the second acquisition position on the transport device when the second suction tube pierces the stopper and suctions the sample.

9. The composite analysis system according to claim 7 or 8, wherein, The maintenance and management object unit includes the first suction tube and the second suction tube. The maintenance and management refers to the cleaning of the first and second suction tubes. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first and second suction tubes from the second side of the transport device.

10. The composite analysis system according to claim 1, wherein, The power operation receiving unit includes a start instruction receiving unit that receives instructions to start the blood cell analysis device and instructions to start the blood coagulation assay device. The blood cell analyzer, the blood coagulation assay device, and the transport device are configured to be positioned and oriented so that the activation instruction receiver can be operated from the second side of the transport device.

11. The composite analysis system according to claim 10, wherein, The start instruction receiving unit includes: The first activation instruction receiving unit receives an instruction to activate the blood cell analysis device; The second start-up instruction receiver receives an instruction to start the blood coagulation measuring device. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first start indication receiver and the second start indication receiver from the second side of the transport device.

12. The composite analysis system according to claim 11, wherein, The first operating surface of the first start indication receiving unit and the second operating surface of the second start indication receiving unit are configured to face opposite to the first side of the transport device.

13. The composite analysis system according to claim 10, wherein, The activation indication receiver includes a shared third activation indication receiver that accepts activation of both the blood cell analysis device and the blood coagulation assay device.

14. The composite analysis system according to claim 1, wherein, The power operation receiving unit includes a shutdown instruction receiving unit that receives instructions to shut down the blood cell analyzer and instructions to shut down the blood coagulation assay device. The blood cell analyzer, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the closure indication receiver from the second side of the transport device.

15. The composite analysis system according to claim 14, wherein, The shutdown instruction receiving unit includes: A first shutdown instruction receiving unit receives an instruction to shut down the blood cell analysis device; The second shut-off instruction receiving unit receives an instruction to shut down the blood coagulation measuring device. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first and second closure indication receivers from the second side of the transport device.

16. The composite analysis system according to claim 14, wherein, The shutdown indication receiving unit includes a shared third shutdown indication receiving unit that accepts the shutdown of the blood cell analysis device and the blood coagulation assay device.

17. The composite analysis system according to claim 1, wherein, The consumable storage section includes a precision management material storage section for storing the precision management materials of the blood cell analysis device and the precision management materials of the blood coagulation assay device. The blood cell analysis device, the blood coagulation determination device, and the transport device are configured in a position and orientation that allows operation of the precision management material placement section from the second side of the transport device.

18. The composite analysis system according to claim 17, wherein, The precision management substance comprises a first precision management substance for precision management of the blood cell analysis device and a second precision management substance for precision management of the blood coagulation assay device. The precision management material placement unit includes: A first precision management substance placement unit is provided in the blood cell analysis device for placing the first precision management substance; The second precision management substance placement section, which is disposed in the blood coagulation measuring device, is used to place the second precision management substance. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first precision management material placement section and the second precision management material placement section from the second side of the transport device.

19. The composite analysis system according to claim 17, wherein, The precision management substance comprises a first precision management substance for precision management of the blood cell analysis device and a second precision management substance for precision management of the blood coagulation assay device. The precision management material placement section includes a shared third precision management material placement section, which is connected to the conveying device and is used to place the first precision management material and the second precision management material. The transport device delivers the first precision management substance placed in the third precision management substance placement section to the blood cell analysis device, and delivers the second precision management substance placed in the third precision management substance placement section to the blood coagulation assay device.

20. The composite analysis system according to claim 1, wherein, The consumable storage section includes a reagent storage section for storing the reagents of the blood cell analysis device and the reagents of the blood coagulation assay device. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the reagent placement section from the second side of the transport device.

21. The composite analysis system according to claim 20, wherein, The reagent comprises a first reagent for the determination performed by the blood cell analyzer and a second reagent for the determination performed by the blood coagulation assay. The reagent placement section includes: A first reagent placement section is used to place the first reagent; The second reagent placement section is used to place the second reagent. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first reagent placement section and the second reagent placement section from the second side of the transport device.

22. The composite analysis system according to claim 21, wherein, The blood cell analysis device has an openable and closable first cover. The blood coagulation testing device has an openable and closable second cover. The first reagent placement section is disposed inside the first cover of the blood cell analysis device. The second reagent placement section is disposed inside the second cover of the blood coagulation assay device. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first cover and the second cover from the second side of the transport device.

23. The composite analysis system according to claim 1, wherein, The consumable storage section includes a cleaning solution storage section for holding cleaning solution for cleaning the blood cell analyzer and cleaning solution for cleaning the blood coagulation assay device. The blood cell analysis device, the blood coagulation determination device, and the transport device are configured in a position and orientation that allows operation of the cleaning solution placement section from the second side of the transport device.

24. The composite analysis system according to claim 23, wherein, The cleaning solution includes a first cleaning solution for cleaning the blood cell analyzer and a second cleaning solution for cleaning the blood coagulation assay device. The cleaning fluid placement section includes: A first cleaning fluid placement section is used to place the first cleaning fluid. The second cleaning fluid placement section is used to place the second cleaning fluid. The blood cell analyzer, the blood coagulation assay device, and the transport device are positioned to allow operation of the first cleaning solution placement section and the second cleaning solution placement section from the second side of the transport device.

25. The composite analysis system according to claim 24, wherein, The first cleaning solution placement section is located at the lower part of the blood cell analysis device. The second cleaning solution placement section is located at the lower part of the blood coagulation measuring device.

26. The composite analysis system according to claim 1, wherein, The terminal device includes an operation instruction receiving unit that receives operation instructions for the blood cell analysis device and operation instructions for the blood coagulation assay device. The blood cell analyzer, the blood coagulation assay device, and the transport device are configured to be positioned and oriented so that the operation instruction receiver can be operated from the second side of the transport device.

27. The composite analysis system according to claim 26, wherein, The operation instruction receiving unit includes: The first operation instruction receiving unit receives operation instructions from the blood cell analysis device; The second operation instruction receiving unit receives operation instructions from the blood coagulation measuring device. The blood cell analysis device, the blood coagulation assay device, and the transport device are configured in a position and orientation that allows operation of the first operation instruction receiving unit and the second operation instruction receiving unit from the second side of the transport device.

28. The composite analysis system according to claim 27, wherein, The first operation instruction receiving unit and the second operation instruction receiving unit are touch panel screens that receive the operation instructions and display information.

29. The composite analysis system according to claim 26, wherein, The operation instruction receiving unit includes a shared third operation instruction receiving unit that receives operation instructions from the blood cell analysis device and the blood coagulation assay device.

30. The composite analysis system according to claim 1, wherein, The terminal device includes an analysis result display unit that displays the analysis results of the blood cell analyzer and the blood coagulation assay device. The blood cell analyzer, the blood coagulation assay device, and the transport device are configured such that the analysis results displayed on the analysis result display unit can be viewed from the second side of the transport device in terms of position and orientation.

31. The composite analysis system according to claim 30, wherein, The analysis results display section includes: The first analysis result display unit displays the first analysis result of the blood cell analysis device; The second analysis result display unit displays the second analysis result of the blood coagulation assay device. The blood cell analyzer, the blood coagulation assay device, and the transport device are configured to allow viewing of the first analysis result displayed on the first analysis result display unit and the second analysis result displayed on the second analysis result display unit from the second side of the transport device, with both positions and orientations suitable for observation.

32. The composite analysis system according to claim 30, wherein, The analysis result display unit includes a shared third analysis result display unit that displays the first analysis result of the blood cell analysis device and the second analysis result of the blood coagulation assay device.

33. The composite analysis system according to claim 1, wherein, The maintenance and management unit includes an error response unit that handles errors generated in the blood cell analyzer and the blood coagulation assay device. The blood cell analysis device, the blood coagulation determination device, and the transport device are configured in a position and orientation that allows operation of the error response unit from the second side of the transport device.

34. The composite analysis system according to claim 33, wherein, The consumable storage section includes a precision management material storage section for storing the precision management materials of the blood cell analysis device and the precision management materials of the blood coagulation assay device. The error refers to the measurement results of the precision-managed substance falling outside the management range. The error handling unit is the precision management material placement unit.

35. The composite analysis system according to claim 1, wherein, The maintenance management department includes a maintenance department that performs maintenance on the blood cell analysis device and the blood coagulation determination device. The blood cell analysis device, the blood coagulation determination device, and the transport device are configured in a position and orientation that allows operation of the repair object from the second side of the transport device.

36. The composite analysis system according to claim 35, wherein, The blood cell analysis device has a first anti-backflow section to prevent liquid backflow. The blood coagulation measuring device has a second anti-backflow section to prevent liquid backflow. The blood cell analysis device, the blood coagulation determination device, and the transport device are configured such that the position and orientation of the first anti-backflow part and the second anti-backflow part, which are the parts to be repaired, can be visually confirmed from the second side of the transport device.

37. The composite analysis system according to claim 1, wherein, The conveying device includes: Main delivery route; The first secondary transport path transports the sample, which is carried by the main transport path, to the blood cell analysis device and then returns it to the main transport path; as well as The second transport path carries the sample, which is transported by the main transport path, to the blood coagulation assay device and then back to the main transport path.

38. The composite analysis system according to claim 1, wherein, The sample is contained in a first sample container transported to the hematology analyzer and a second sample container transported to the blood coagulation assay device. The conveying device has: The code reading unit is attached to the first sample container and the second sample container and is used to identify the identification code of the first sample container and the second sample container separately. The delivery control unit determines the delivery destination of the first sample container and the second sample container based on the identification code read by the code reading unit.

39. The composite analysis system according to claim 1, wherein, The composite analysis system also includes a sample setting unit for setting the sample. The sample setting unit is connected to the transport device between the blood cell analysis device and the blood coagulation assay device.

Images