A skin closure dressing aerosol and method of manufacture
By using film-forming dressing matrices such as polyvinyl alcohol, fish scale collagen powder, and nanocellulose, combined with effective drugs to prepare aerosols, the problem of poor sealing effect of water-based aerosol dressings has been solved, achieving rapid film formation and high-strength sealing, and promoting wound healing.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG GUOYAO JINGYUE AEROSOL CO LTD
- Filing Date
- 2025-08-29
- Publication Date
- 2026-07-03
AI Technical Summary
Existing water-based aerosol dressings have difficulty forming a tight, high-strength protective film quickly on the wound surface, and the film-forming material may irritate the wound, resulting in limited sealing effect.
Polyvinyl alcohol, fish scale collagen powder, and nanocellulose are used as the film-forming dressing matrix, combined with effective drugs such as Panax notoginseng extract, Lithospermum erythrorhizon extract, Coptis chinensis extract, D-panthenol, and oxytetracycline. The aerosol is prepared by high-speed shearing and high-temperature sterilization to form a rapidly forming and biocompatible closed protective layer.
It enables water-based aerosol dressings to quickly form a flexible and high-strength protective layer on the wound surface, reducing skin irritation and promoting hemostasis, sterilization and healing. It is suitable for timely closure of minor abrasions, scratches and other minor injuries.
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical dressing technology, specifically to a skin wound occlusive dressing aerosol and its preparation method. Background Technology
[0002] Medical dressings are protective materials used to cover skin wounds such as abrasions, cuts, incisions, and burns to stop bleeding, promote healing, and prevent infection. Traditional medical dressings mainly consist of gauze and cotton pads. Before use, the wound is cleaned, disinfected, and treated with medication, then covered with gauze. This traditional gauze provides good protection for open, deep wounds and is absorbent and breathable. For minor abrasions and cuts, bandaging with gauze is inconvenient, so people often use adhesive bandages coated with benzalkonium chloride or gel dressings. However, regardless of whether gauze, adhesive bandages, or gel dressings are used, the sealing effect remains poor. Pathogens can easily penetrate through the mesh of the gauze and the edges of the adhesive bandage, leading to wound infection. Topical gel dressings such as chitosan, hyaluronic acid, carbomer, and sodium alginate have poor film-forming ability, a long film-forming time, and are prone to detachment from the skin after film formation.
[0003] Aerosol dressings spray onto the wound surface to form a protective film, effectively isolating the wound from external bacterial contamination. Furthermore, aerosol dressings can incorporate antibacterial, disinfectant, analgesic, hemostatic, and repairing agents to provide long-lasting wound protection and promote healing. Compared to gauze bandages and adhesive bandages, aerosol dressings are more comfortable and do not restrict movement. For minor abrasions, scratches, and bedsores, the aerosol spray provides immediate protection and repair, making it convenient and ideal for home use.
[0004] Although aerosol dressings are convenient to use, their sealing effect remains limited due to limitations in spray volume and thickness. This is primarily manifested in the difficulty of rapidly forming a tight and high-strength protective film. The primary purpose of medical dressings is to protect wounds and prevent secondary damage from external contamination and infection. Therefore, forming a strong protective barrier film that adheres closely to the skin is the primary objective of dressings. Chinese invention patent publication number CN114306729B discloses a biological antibacterial film-forming liquid medical dressing and its preparation method. By dissolving nitrocellulose in ethanol and ethyl acetate as a film-forming agent, a high-strength film can be rapidly formed with good sealing effect and good breathability. However, the film-forming agent needs to be dissolved in an organic solvent, which can be highly irritating and harmful to wounds. While water-based aerosol dressings are less irritating, they form a slow film initially and have limited sealing properties. Summary of the Invention
[0005] The technical problem to be solved by this invention is to enable water-based aerosol dressings to quickly form a protective layer on the surface of wounds, alleviate the irritation of the dressing to the skin, promote rapid hemostasis, antibacterial activity, wound healing and prevent bacterial invasion of the wound. Based on this, a skin wound sealing dressing aerosol and its preparation method are proposed.
[0006] The specific technical solution adopted by this invention to solve its technical problem is as follows:
[0007] This invention provides a skin wound occlusive dressing aerosol, characterized by being composed of an effective drug, a film-forming dressing matrix, and a propellant in a mass ratio of (0.2-0.5):100:(35-40); wherein,
[0008] The effective drugs, by weight, include: 30-40 parts of Panax notoginseng extract, 20-30 parts of Lithospermum erythrorhizon extract, 10-20 parts of Coptis chinensis extract, 10-15 parts of D-panthenol, 5-10 parts of oxytetracycline, and 5-10 parts of analgesic.
[0009] The film-forming dressing matrix comprises, by weight, 0.3-0.5 parts fish scale collagen, 0.2-0.3 parts polyvinyl alcohol, 0.05-0.1 parts nanocellulose, 0.05-0.1 parts carbomer, and 100 parts deionized water;
[0010] The propellant is nitrogen and / or carbon dioxide.
[0011] Preferably, the effective drug is composed of 35 parts by weight of Panax notoginseng extract, 25 parts of Lithospermum erythrorhizon extract, 15 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of analgesic.
[0012] More preferably, the pain reliever is at least one of borneol, menthol, and diclofenac diethylamine. The pain reliever can alleviate the inflammatory response, reducing inflammatory swelling and relieving pain. Care should be taken to control the dosage and avoid using high concentrations that may irritate the wound.
[0013] Preferably, the Panax notoginseng extract is a concentrated extract at a ratio of 10:1. The Panax notoginseng extract contains active ingredients such as saponins, polysaccharides, and flavonoids, and has effects such as promoting blood circulation, removing blood stasis, stopping bleeding, and anti-inflammation. It can moderately shorten clotting time and assist in stopping bleeding from external injuries.
[0014] Preferably, the shikonin content of the comfrey extract is not less than 30%. Shikonin extracted from comfrey can inhibit local inflammatory responses, and has the effects of clearing heat and cooling blood, detoxifying and relieving pain. It also has good biocompatibility with epidermal tissue. For minor abrasions and burns, shikonin can continuously penetrate the skin, providing antibacterial and anti-inflammatory effects and promoting wound healing.
[0015] Preferably, the Coptis chinensis extract is a concentrated extract at a ratio of 10:1. The Coptis chinensis extract contains berberine, a natural broad-spectrum antibacterial component that has a strong killing effect on pathogenic microorganisms such as Streptococcus pyogenes.
[0016] D-Panthenol has moisturizing properties, can resist external stimuli, avoid drug-induced skin irritation, soothe wounds, and form a protective barrier for the skin; at the same time, panthenol participates in the skin tissue repair process and accelerates wound healing.
[0017] Otinididine has broad-spectrum antibacterial properties, can quickly kill pathogens, has low irritation, and is well compatible with skin tissue. It is used for disinfection and sterilization of skin wounds, and effectively prevents local infection.
[0018] Preferably, the polyvinyl alcohol is selected from polyvinyl alcohol with a degree of hydrolysis of 88%, such as at least one of PVA0588, PVA1788, and PVA4088. It is readily soluble in water and can quickly form a film after spraying, thus assisting the fish scale collagen powder in rapid initial film formation.
[0019] Fish scale collagen powder has good water solubility. After spraying, it forms a film with excellent toughness and breathability. It has good biocompatibility with skin tissue, binds tightly, is non-irritating, and has high adhesion strength in the later stage of film formation. It can effectively seal wounds, prevent bacteria from entering the wound, and provide a protective barrier for skin wound repair.
[0020] Nanocellulose binds to water molecules via hydrogen bonds to form a three-dimensional network structure, maintaining the stability of the aerosol. After spraying and forming a film, it constructs a network structure that promotes air permeability.
[0021] Preferably, the carbomer is selected from either carbomer 941 or carbomer U10. Carbomer has certain moisturizing properties and forms a protective film on the skin surface, which can reduce the damage of external irritants to the skin and form a skin barrier.
[0022] This invention discloses a formulation for a skin wound closure aerosol. Utilizing the rapid initial film-forming properties of polyvinyl alcohol and the biocompatibility and skin-adhesive properties of fish scale collagen powder, combined with nanocellulose and carbomer as the film-forming dressing matrix, it achieves rapid film-forming and wound-sealing effects. For minor superficial abrasions, scratches, and bedsores, the aerosol can be conveniently sprayed to quickly form a protective film. This protective layer is flexible, adheres well, is not easily detached, and isolates external bacteria and contaminants, as well as external irritants. Containing effective hemostatic, bactericidal, and analgesic drugs, it can promptly stop bleeding, sterilize and reduce swelling, relieve pain, and promote healing.
[0023] This invention also provides a method for preparing a skin wound occlusive dressing aerosol, the specific preparation method of which is as follows:
[0024] S1. By weight, add 0.3-0.5 parts of fish scale collagen to 40 parts of deionized water and stir at low speed for 30-60 minutes at room temperature; add 0.2-0.3 parts of polyvinyl alcohol to 30 parts of deionized water and stir at low speed for 20-30 minutes at 90℃, then cool to room temperature; add 0.05-0.1 parts of nanocellulose to 20 parts of deionized water and stir at low speed for 30-60 minutes at room temperature; add 0.05-0.1 parts of carbomer to 10 parts of deionized water and stir at low speed for 30-60 minutes at room temperature; mix the above mixtures, stir evenly, and pass through a 100-mesh sieve to obtain the film-forming dressing matrix;
[0025] S2. Weigh out 30-40 parts of Panax notoginseng extract, 20-30 parts of Lithospermum erythrorhizon extract, 10-20 parts of Coptis chinensis extract, 10-15 parts of D-panthenol, 5-10 parts of oxytetracycline, and 5-10 parts of analgesic agent by weight and add them to a planetary mixer to mix evenly to obtain the effective drug.
[0026] S3. The effective drug and film-forming dressing matrix are dispersed in a homogenizer at a mass ratio of (0.2-0.5):100 at a high-speed shearing speed of 8000-10000 rpm / min for 10-15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture is metered and canned in an aluminum alloy can, the valve is sealed, and the propellant is added. After weighing and water bath testing, the nozzle is installed to obtain a skin wound occlusive dressing aerosol.
[0027] Preferably, the pressure inside the aluminum alloy can is controlled at 0.60-0.75 MPa after the propellant is filled. The film-forming dressing matrix has a certain viscosity, and in order to fully propel the contents out, the pressure is controlled at a relatively high level after the propellant is filled.
[0028] Compared with the prior art, the beneficial effects of the present invention are:
[0029] This invention relates to a water-based aerosol medical dressing. It utilizes polyvinyl alcohol, fish scale collagen powder, nanocellulose, and carbomer as a synergistic film-forming dressing matrix. The polyvinyl alcohol solution rapidly loses its moisture upon spraying, enabling rapid initial film formation and exhibiting high adhesion strength in the later stages. The selected materials possess excellent biocompatibility, causing no significant irritation, and forming a flexible, high-strength protective layer that adheres tightly to the wound, creating a sealed protective barrier with good breathability. By appropriately incorporating effective drugs with hemostatic, bactericidal, and analgesic effects into the dressing, it can promptly stop bleeding, sterilize and reduce swelling, relieve pain, and promote healing of the wound. This aerosol dressing is suitable for the timely closure of minor superficial abrasions, scratches, and bedsores, but is not suitable for use on deep open skin wounds. Detailed Implementation
[0030] To enable those skilled in the art to further understand the technical means, technical objectives, and technical effects of the present invention, the present invention will be described in detail below with reference to embodiments; unless otherwise specified, all percentage contents (%) involved in the present invention are mass percentage contents; all raw materials used are medical grade raw materials; the inner liner of the mixing equipment, planetary mixer, and homogenizer used is made of 316L stainless steel or PTFE coating to avoid corrosion or chemical reactions; the preparation and canning environment meets sanitary standards to avoid cross-contamination.
[0031] Some raw material specifications used in embodiments of the present invention:
[0032] Panax notoginseng extract: an extract concentrated at a ratio of 10:1.
[0033] Comfrey extract: Comfrey extract content 30%.
[0034] Coptis chinensis extract: an extract concentrated at a ratio of 10:1.
[0035] Polyvinyl alcohol: PVA0588 with a degree of alcoholysis of 88%.
[0036] Nanocellulose: active ingredient content greater than 98%, particle size 3-20nm, carboxyl content 0.5-1.5mmol / g.
[0037] Carbomer: Carbomer 941.
[0038] Examples 1-3
[0039] The film-forming dressing matrix was prepared according to the proportions in Table 1 for each implementation scheme. Fish scale collagen was added to 400 ml of deionized water and stirred at 50 rpm for 60 min at room temperature; polyvinyl alcohol was added to 300 ml of deionized water and stirred at 50 rpm for 30 min at 90°C, then cooled to room temperature; nanocellulose was added to 200 ml of deionized water and stirred at 50 rpm for 60 min at room temperature; carbomer was added to 100 ml of deionized water and stirred at 50 rpm for 30 min at room temperature; the above mixtures were combined, stirred evenly, and passed through a 100-mesh sieve to obtain the film-forming dressing matrix.
[0040] Comparative Example 1
[0041] The film-forming dressing matrix was prepared according to the proportions in Table 1. Polyvinyl alcohol was added to 700 ml of deionized water and stirred at 90°C and 50 rpm for 30 min, then cooled to room temperature. Nanocellulose was added to 200 ml of deionized water and stirred at 50 rpm for 60 min at room temperature. Carbomer was added to 100 ml of deionized water and stirred at 50 rpm for 30 min at room temperature. The above mixtures were combined, stirred evenly, and passed through a 100-mesh sieve to obtain the film-forming dressing matrix.
[0042] Comparative Example 2
[0043] The film-forming dressing matrix was prepared according to the proportions in Table 1. Fish scale collagen was added to 700 ml of deionized water and stirred at 50 rpm for 60 min at room temperature; nanocellulose was added to 200 ml of deionized water and stirred at 50 rpm for 60 min at room temperature; carbomer was added to 100 ml of deionized water and stirred at 50 rpm for 30 min at room temperature; the above mixtures were combined, stirred evenly, and passed through a 100-mesh sieve to obtain the film-forming dressing matrix.
[0044] Comparative Example 3
[0045] The film-forming dressing matrix was prepared according to the proportions in Table 1. Fish scale collagen was added to 600 ml of deionized water and stirred at 50 rpm for 60 min at room temperature; polyvinyl alcohol was added to 300 ml of deionized water and stirred at 50 rpm for 30 min at 90℃, then cooled to room temperature; carbomer was added to 100 ml of deionized water and stirred at 50 rpm for 30 min at room temperature; the above mixtures were combined, stirred evenly, and passed through a 100-mesh sieve to obtain the film-forming dressing matrix.
[0046] Table 1 Film-forming dressing matrix formulation
[0047] formula Fish scale collagen (g) Polyvinyl alcohol (g) Nanocellulose (g) Carbomer (g) Deionized water (ml) Example 1 4.5 2.5 1.0 0.5 1000 Example 2 3.5 3.0 1.0 1.0 1000 Example 3 5.0 2.0 0.5 1.0 1000 Comparative Example 1 -- 7.0 1.0 0.5 1000 Comparative Example 2 7.0 -- 1.0 0.5 1000 Comparative Example 3 5.5 2.5 -- 0.5 1000
[0048] Film-forming test of film-forming dressing matrix:
[0049] The film-forming dressing matrix of Examples 1-3 and Comparative Examples 1-3 was sprayed onto the silicone surface simulating human skin. The initial film-forming coagulation was measured with the sprayed layer not sticking to the hand as the standard. The initial coagulation time was tested and is shown in Table 2. Two hours after spraying, the peel strength of the dressing film at a peel angle of 180° was tested using a universal tensile testing machine and is shown in Table 2.
[0050] Table 2 Film-forming test of film-forming dressing matrix
[0051] Test metrics Initial setting time (min) Peel strength at 180° (N / cm) Example 1 6 2.4 Example 2 5 2.2 Example 3 5 2.5 Comparative Example 1 3 1.8 Comparative Example 2 10 2.2 It broke when pulled apart, but was not completely peeled off. Comparative Example 3 5 2.7
[0052] Example 4
[0053] Weigh out 35 parts of Panax notoginseng extract, 25 parts of Lithospermum erythrorhizon extract, 15 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of borneol (an analgesic) according to the weight ratio, add them to a planetary mixer and mix evenly to obtain the effective drug.
[0054] The effective drug and the film-forming dressing matrix of Example 1 were dispersed in a homogenizer at a mass ratio of 0.3:100 at a high-speed shearing speed of 10,000 rpm / min for 15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture was metered and canned in an aluminum alloy can, the valve was sealed, and compressed nitrogen was filled in as a propellant. The amount of propellant filled was 35% of the mass of the canned material, and the standard pressure for filling the propellant was 0.75 MPa. After weighing and water bath testing, a nozzle was installed to obtain a skin wound occlusive dressing aerosol.
[0055] Example 5
[0056] Weigh out 40 parts of Panax notoginseng extract, 20 parts of Lithospermum erythrorhizon extract, 20 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of diclofenac diethylamine (an analgesic) according to the weight ratio, add them to a planetary mixer and mix evenly to obtain the effective drug.
[0057] The effective drug and the film-forming dressing matrix of Example 2 were dispersed in a homogenizer at a mass ratio of 0.5:100 at a high-speed shearing speed of 8000 rpm / min for 15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture was metered and canned in an aluminum alloy can, and the valve was sealed. Compressed nitrogen was filled in as a propellant, with the propellant filling amount being 36% of the canned material mass. The standard pressure for filling the propellant was 0.75 MPa. After weighing and water bath testing, a nozzle was installed to obtain a skin wound occlusive dressing aerosol.
[0058] Example 6
[0059] Weigh out 40 parts of Panax notoginseng extract, 20 parts of Lithospermum erythrorhizon extract, 20 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of diclofenac diethylamine (an analgesic) according to the weight ratio, add them to a planetary mixer and mix evenly to obtain the effective drug.
[0060] The effective drug and the film-forming dressing matrix of Example 3 were dispersed in a homogenizer at a mass ratio of 0.2:100 at a high-speed shearing speed of 8000 rpm / min for 15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture was metered and canned in an aluminum alloy can, the valve was sealed, and compressed nitrogen was filled in as a propellant. The propellant filling amount was 37% of the canned material mass, and the standard pressure for filling the propellant was 0.75 MPa. After weighing and water bath testing, a nozzle was installed to obtain a skin wound occlusive dressing aerosol.
[0061] Comparative Example 4
[0062] Weigh out 40 parts of Panax notoginseng extract, 20 parts of Lithospermum erythrorhizon extract, 20 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of diclofenac diethylamine (an analgesic) according to the weight ratio, add them to a planetary mixer and mix evenly to obtain the effective drug.
[0063] The effective drug and the film-forming dressing matrix of Comparative Example 1 were dispersed at a mass ratio of 0.5:100 in a homogenizer at a high-speed shearing speed of 8000 rpm / min for 15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture was metered and filled into an aluminum alloy can, and the valve was sealed. Compressed nitrogen was added as a propellant, with the propellant filling amount being 36% of the canned material mass. The standard pressure for filling the propellant was 0.70-0.75 MPa. After weighing and water bath testing, a nozzle was installed to obtain a skin wound occlusive dressing aerosol.
[0064] Comparative Example 5
[0065] Weigh out 40 parts of Panax notoginseng extract, 20 parts of Lithospermum erythrorhizon extract, 20 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of diclofenac diethylamine (an analgesic) according to the weight ratio, add them to a planetary mixer and mix evenly to obtain the effective drug.
[0066] The effective drug and the film-forming dressing matrix of Comparative Example 2 were dispersed at a mass ratio of 0.5:100 in a homogenizer at a high-speed shearing speed of 8000 rpm / min for 15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture was metered and filled into aluminum alloy cans, the valves were sealed, and compressed nitrogen was filled in as a propellant. The propellant filling amount was 36% of the canned material mass, and the standard pressure for filling the propellant was 0.70-0.75 MPa. After weighing and water bath testing, a nozzle was installed to obtain a skin wound occlusive dressing aerosol.
[0067] Comparative Example 6
[0068] Weigh out 40 parts of Panax notoginseng extract, 20 parts of Lithospermum erythrorhizon extract, 20 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of diclofenac diethylamine (an analgesic) according to the weight ratio, add them to a planetary mixer and mix evenly to obtain the effective drug.
[0069] The effective drug and the film-forming dressing matrix of Comparative Example 3 were dispersed at a mass ratio of 0.5:100 in a homogenizer at a high-speed shearing speed of 8000 rpm / min for 15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture was metered and filled into an aluminum alloy can, and the valve was sealed. Compressed nitrogen was added as a propellant, with the propellant filling amount being 36% of the canned material mass. The standard pressure for filling the propellant was 0.70-0.75 MPa. After weighing and water bath testing, a nozzle was installed to obtain a skin wound occlusive dressing aerosol.
[0070] Film-forming effect of dressing aerosols:
[0071] The dressing aerosols of Examples 4-6 and Comparative Examples 4-6 were sprayed onto the silicone surface simulating human skin. The initial film-forming and coagulating time was measured when the sprayed layer was not sticky to the hand. See Table 3. Two hours after spraying, the peel strength of the dressing film at a peel angle of 180° was tested using a universal tensile testing machine. See Table 3. The dressing aerosols were sprayed onto the surface of human skin. Two hours after spraying, the adhesion effect between the dressing aerosol film and the skin was observed. The adhesion effect was judged by tearing by hand. The breathability after the dressing film was formed was judged by the skin moisture residue and body feel after tearing by hand. See Table 3.
[0072] Table 3 Film-forming test of dressing aerosol
[0073] Test metrics Initial setting time (min) Peel strength at 180° (N / cm) Skin surface sealing effect Example 4 6 2.1 It adheres tightly to the skin with no lifting at the edges, and the adhesive is firm when peeled off by hand, leaving no moisture residue on the skin. Example 5 6 1.8 It adheres tightly to the skin with no lifting at the edges, and the adhesive is firm when peeled off by hand, leaving no moisture residue on the skin. Example 6 6 1.9 It adheres tightly to the skin with no lifting at the edges, and the adhesive is firm when peeled off by hand, leaving no moisture residue on the skin. Comparative Example 4 4 1.6 It doesn't adhere well to the skin, the edges lift up, the adhesive is loose when peeled off by hand, and a small amount of moisture remains on the skin. Comparative Example 5 10 2.0 tensile strength It adheres tightly to the skin with no lifting at the edges, and the adhesive is firm when peeled off by hand, leaving no moisture residue on the skin. Comparative Example 6 7 2.3 It adheres tightly to the skin with no lifting at the edges. It is firmly bonded when peeled off by hand, leaving a significant amount of moisture residue on the skin.
[0074] Based on the test records in Tables 2 and 3, the film-forming dressing matrix used in the aerosol dressing of this invention exhibits a rapid initial setting effect, facilitating the rapid formation of a sealing barrier. It also demonstrates good peel strength in the later stages of film formation, uniform film formation, tight adhesion to the skin, and no peeling or edge lifting, thus achieving a long-lasting sealing effect. In Examples 4-6, the addition of the effective drug did not significantly negatively impact the initial setting time or the sealing effect of the dressing film. Comparative tests in Examples 4-6 showed that fish scale collagen significantly increased skin adhesion; nanocellulose significantly improved film permeability. In aerosols without nanocellulose, the protected skin retained more moisture after film formation.
[0075] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments; the embodiments and descriptions in the specification are merely illustrative of the principles and objectives of the invention. The synergistic effect of different film-forming agents and their compatibility with effective drugs are key to achieving the desired effects of aerosol dressings. Various changes and modifications can be made without departing from the spirit and scope of the present invention, and all such changes and modifications fall within the scope of the claimed invention.
Claims
1. A skin wound occlusive dressing aerosol, characterized in that: It is composed of an effective drug, a film-forming dressing matrix, and a propellant in a mass ratio of (0.2-0.5):100:(35-40); wherein, The effective drugs, by weight, include: 30-40 parts of Panax notoginseng extract, 20-30 parts of Lithospermum erythrorhizon extract, 10-20 parts of Coptis chinensis extract, 10-15 parts of D-panthenol, 5-10 parts of oxytetracycline, and 5-10 parts of analgesic. The film-forming dressing matrix comprises, by weight, 0.3-0.5 parts fish scale collagen, 0.2-0.3 parts polyvinyl alcohol, 0.05-0.1 parts nanocellulose, 0.05-0.1 parts carbomer, and 100 parts deionized water; The propellant is nitrogen and / or carbon dioxide.
2. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The effective drug is composed of 35 parts by weight of Panax notoginseng extract, 25 parts of Lithospermum erythrorhizon extract, 15 parts of Coptis chinensis extract, 10 parts of D-panthenol, 10 parts of oxytetracycline, and 5 parts of pain reliever.
3. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The pain reliever is selected from at least one of borneol, menthol, and diclofenac diethylamine.
4. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The Panax notoginseng extract is a concentrated extract at a ratio of 10:
1.
5. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The content of shikonin in the gromwell extract is not less than 30%.
6. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The Coptis chinensis extract is a concentrated extract at a ratio of 10:
1.
7. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The polyvinyl alcohol is selected from at least one of PVA0588, PVA1788, and PVA4088 with a degree of alcoholysis of 88%.
8. The skin wound occlusive dressing aerosol according to claim 1, characterized in that: The carbomer is selected from either carbomer 941 or carbomer U10.
9. A method for preparing the skin wound occlusive dressing aerosol according to any one of claims 1-8, characterized in that: The specific preparation method is as follows: S1. By weight, add 0.3-0.5 parts of fish scale collagen to 40 parts of deionized water and stir at low speed for 30-60 minutes at room temperature; add 0.2-0.3 parts of polyvinyl alcohol to 30 parts of deionized water and stir at low speed for 20-30 minutes at 90℃, then cool to room temperature; add 0.05-0.1 parts of nanocellulose to 20 parts of deionized water and stir at low speed for 30-60 minutes at room temperature; add 0.05-0.1 parts of carbomer to 10 parts of deionized water and stir at low speed for 30-60 minutes at room temperature; mix the above mixtures, stir evenly, and pass through a 100-mesh sieve to obtain the film-forming dressing matrix; S2. Weigh out 30-40 parts of Panax notoginseng extract, 20-30 parts of Lithospermum erythrorhizon extract, 10-20 parts of Coptis chinensis extract, 10-15 parts of D-panthenol, 5-10 parts of oxytetracycline, and 5-10 parts of analgesic agent by weight and add them to a planetary mixer to mix evenly to obtain the effective drug. S3. The effective drug and film-forming dressing matrix are dispersed in a homogenizer at a mass ratio of (0.2-0.5):100 at a high-speed shearing speed of 8000-10000 rpm / min for 10-15 min. After passing through a 100-mesh sieve and being sterilized by high-temperature instantaneous sterilization, the mixture is metered and canned in an aluminum alloy can, the valve is sealed, and the propellant is added. After weighing and water bath testing, the nozzle is installed to obtain a skin wound occlusive dressing aerosol.
10. The method for preparing the skin wound occlusive dressing aerosol according to claim 9, characterized in that: After the propellant is filled, the pressure inside the aluminum alloy can is controlled at 0.60-0.75 MPa.