Diabetes carbon-egg proportion dynamic adjusting system and method based on metabolic capability grading

Abstract

The invention discloses a diabetic carbon-egg proportion dynamic adjusting system and method based on metabolic capacity grading, and the system comprises a grading evaluation module which is used for precisely reversely deducing the intrinsic insulin secretion response efficiency of a user through the form of a blood glucose dynamic curve monitored by a CGM, and carrying out the grading evaluation according to different index data and core characteristics; the proportion calculation module is used for calculating a protein volume ratio based on a three-step calculation method; and the safety correction module is used for outputting a basic correction proportion based on a safety mechanism double-path mechanism, and performing dynamic management on the protein intake by setting a protein upper limit and according to metabolism capability grading. Diet suggestions are made for crowds with different metabolic capabilities by setting a grading evaluation module; the protein volume ratio is calculated through the proportion calculation module, and complex food calorie calculation is not needed through the protein volume ratio; by setting a safety correction module, a protein upper limit is set based on renal functions and obesity degrees, and protein mass excess is prevented.

Description

Technical Field

[0001] This invention relates to a system and method for dynamically adjusting the carbohydrate-protein ratio in diabetes, and more particularly to a system and method for dynamically adjusting the carbohydrate-protein ratio in diabetes based on metabolic capacity grading. Background Technology

[0002] The existing dynamic adjustment system for the carbohydrate-protein ratio of diabetes based on metabolic capacity classification has a complicated method for calculating dietary calories, requiring users to memorize a large number of food calories and GI values, which is too difficult to operate, especially for elderly users. Uniform dietary recommendations cannot be adapted to people with different metabolic capacities, ignoring individual differences; Blindly restricting carbon intake can lead to an excess of protein, resulting in gluconeogenesis-induced hyperglycemia or kidney damage, and carries the risk of nutritional imbalance. Summary of the Invention

[0003] To address the shortcomings of the aforementioned technologies, this invention provides a dynamic adjustment system and method for the carbon-protein ratio in diabetes based on metabolic capacity grading.

[0004] To solve the above technical problems, the technical solution adopted by the present invention is: a dynamic adjustment system for the carbon protein ratio of diabetes based on metabolic capacity grading, including a grading assessment module, which is used to accurately infer the user's intrinsic insulin secretion response efficiency, i.e., core characteristics, through the glycemic dynamics curve morphology monitored by CGM, and to perform metabolic grading assessment based on different indicator data and core characteristics. The ratio calculation module is used to calculate the protein volume ratio based on a three-step calculation method, which facilitates subsequent ratio correction. The safety correction module is used to output a basic correction ratio based on a dual-path safety mechanism, and to ensure nutritional safety by setting a protein upper limit and dynamically managing protein intake according to metabolic capacity classification.

[0005] Furthermore, the three-step calculation method includes basic ratio calculation, renal function impairment correction calculation, and obesity degree correction calculation.

[0006] A dynamic adjustment method for the carbohydrate protein ratio in diabetes based on metabolic capacity grading includes the following steps: Step S1: Conduct standardized tests on users based on the graded assessment module, quantify using four-dimensional monitoring indicators, and grade metabolism according to the quantification results and metabolic capacity grading standards. Step S2: Determine the user's baseline proportion through metabolic grading; then, after sequential renal function correction and obesity correction calculations, calculate the protein volume ratio based on the protein volume ratio calculation formula; the protein volume ratio calculation formula is: ; Where G is the basic proportion; This is the kidney correction factor; For obesity correction factor; Step S3: Determine the basic correction ratio based on whether carbohydrates are high-GI foods; and set the upper limit for protein based on kidney function and degree of obesity.

[0007] Furthermore, in step S1, standardized testing is performed, specifically including the following steps: Step A1: Measure the user's baseline blood glucose level before the user's meal; Step A2: The user consumes 50g of standardized carbohydrates and selects the type of carbohydrates they consume; Step A3: Perform 4 hours of CGM monitoring; Step A4: Based on the CGM monitoring results, quantify them using four-dimensional monitoring indicators; Step A5: Based on the results of the four-dimensional monitoring indicators in Step A4 and using the standardized comprehensive scoring formula, perform independent metabolic grading; the metabolic capacity grading criteria are as follows: 1. If the peak blood glucose increase is greater than 6.0 mmol / L, the time to peak (T) is greater than 2.5 hours, the area under the blood glucose curve increases by more than 15 mmol / L·h, and the blood glucose clearance half-life exceeds 60 minutes, then the metabolic capacity is considered to be Grade 1, i.e., severely abnormal. 2. If the peak blood glucose increase is 4.5-6.0 mmol / L, the time to reach the peak is 2.0 to 2.5 hours, the increase in the area under the blood glucose curve is 12 to 15 mmol / L·h, and the blood glucose clearance half-life is 40 to 60 minutes, then the metabolic capacity is considered to be grade 2, i.e., moderately abnormal. 3. If the peak blood glucose increase is 3.0-4.5 mmol / L, the time to reach the peak is 1.5 to 2.0 hours, the increase in the area under the blood glucose curve is 9 to 12 mmol / L·h, and the blood glucose clearance half-life is 25 to 40 minutes, then the metabolic capacity is considered to be grade 3, i.e., mildly abnormal. IV. If the peak blood glucose increment is 1.5-3.0 mmol / L, the time to reach peak is 1.0 to 1.5 hours, the area under the blood glucose curve increment is 6 to 9 mmol / L·h, and the blood glucose clearance half-life is 15 to 25 minutes, then the metabolic capacity is considered to be level 4, i.e., the critical state. 5. If the peak blood glucose increase is less than 1.5 mmol / L, the time to reach the peak is less than 1.0 hour, the increase in the area under the blood glucose curve is less than 6 mmol / L·h, and the blood glucose clearance half-life is less than 15 minutes, then the metabolic capacity is considered to be level 5, which is basically normal.

[0008] Furthermore, the four-dimensional monitoring indicators in step S1 include the increase in peak blood glucose levels. Time to peak (T) and AUC increment (area under the blood glucose curve) are also important metrics. Clear half-life .

[0009] Furthermore, the increase in peak blood glucose levels The calculation formula is: ; in, This refers to the peak blood glucose level after a meal; This refers to the baseline blood glucose level before a meal; The formula for calculating peak time is: ; in, This refers to the time point of the blood glucose peak. This is the point in time to begin eating; Increment The calculation formula is: ; in, Blood glucose levels within a specific time period Baseline blood glucose level.

[0010] Furthermore, the standardized comprehensive scoring formula in step A5 is as follows: ; in, The weighting of the peak blood glucose increment; This represents the increase in peak blood glucose levels. Weighting for peak time; Peak time; The weights for the AUC increment; This is the AUC increment; To clear the weight of half-life; To clear the half-life; The standardized coefficient for the AUC increment; The standardized coefficient for peak time; The standardized coefficient of AUC; The standardized factor for clearing the half-life.

[0011] Furthermore, the calculation of the protein volume ratio in step S2 specifically includes the following steps: Step B1: Calculate the comprehensive metabolic score (Score) based on the comprehensive scoring algorithm. The comprehensive metabolic score corresponds to the metabolic capacity level in Step S1, and the baseline proportion (G) is determined based on the metabolic capacity level. The comprehensive scoring algorithm is as follows: ; in, This represents the increase in peak blood glucose levels. Peak time; This is the AUC increment; To clear the half-life; Step B2: Adjust based on renal function, calculate eGFR based on relevant user indicators; if eGFR is less than 60, adjust the renal correction factor. The value is 0.8; if the eGFR is not less than 60, the renal correction factor is maintained. =1; Step B3: Adjust based on user obesity; if the user's MBI is greater than 28, then the obesity correction factor is applied. Set to 1.2; if MBI is not greater than 28, then the obesity correction factor is... Keep it at 1; Step B4: Calculate the protein volume ratio based on the protein volume ratio calculation formula.

[0012] Further, step S3 determines the basic correction ratio, specifically including the following steps: Step C1: Enter the food type; Step C2: Determine if the food is a high-GI food; Step C3: If the food is a high-GI food, the basic correction ratio is 1.2 times the protein volume ratio in step S2; if the food is a medium-low GI food, the basic correction ratio is 1.1 times the protein volume ratio in step S2; if the food is a medium-GI food, the basic correction ratio will remain the same as the protein volume ratio in step S2.

[0013] Furthermore, step S3 sets an upper limit for protein levels, specifically including the following steps: Step D1: Determine the metabolic capacity level. If the metabolic capacity is level 4 or 5, the upper limit of protein is 1.2g / kg; if the metabolic capacity is level 1 to 3, proceed to step D2. Step D2: Determine if the eGFR is less than 60. If the eGFR is less than 60, the upper limit of protein is 0.8 g / kg; if the eGFR is not less than 60, the upper limit of protein is 1.0 g / kg. Step D3: Determine if the user's BMI is less than 30. If the BMI is less than 30, maintain the protein upper limit in Step D2; if the BMI is not less than 30, reduce the protein upper limit in Step D2 by 0.1g / kg.

[0014] This invention discloses a dynamic adjustment system and method for the carbohydrate-protein ratio in diabetes based on metabolic capacity grading. It utilizes a grading assessment module to monitor the glycemic dynamics curve morphology of the CGM (carbohydrate glycemic index) and performs metabolic grading assessment based on different indicator data and core characteristics. This allows for targeted dietary recommendations for individuals with different metabolic capacities. Furthermore, a ratio calculation module calculates the protein volume ratio, eliminating the need for complex food calorie calculations and simplifying the process. Finally, a safety correction module sets an upper limit for protein intake based on renal function and obesity levels to prevent excessive protein intake and ensure nutritional balance. Attached Figure Description

[0015] Figure 1 This is a logic flowchart of the present invention.

[0016] Figure 2 This is a flowchart of the standardized test in this invention.

[0017] Figure 3 This is a flowchart of the scoring and grading process in this invention.

[0018] Figure 4 This is a flowchart of the ratio calculation module in this invention.

[0019] Figure 5 This is a flowchart for setting the upper limit of protein in this invention.

[0020] Figure 6 This is a flowchart of Embodiment 3 of the present invention. Detailed Implementation

[0021] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0022] Example 1:

[0023] like Figures 1 to 5 The illustrated dynamic adjustment system for the carbohydrate-protein ratio in diabetes based on metabolic capacity grading includes a grading assessment module. This module uses the glycemic dynamics curve morphology monitored by CGM (Continuous Glucose Monitoring) to perform reverse diagnostic logic, non-invasively and accurately inferring the user's intrinsic insulin secretion response efficiency, i.e., core characteristics. It performs metabolic grading assessment based on different indicator data and core characteristics, and suggests corresponding carbohydrate-protein ratios. The carbohydrate-protein ratio is the volume ratio of carbohydrates to protein. The glycemic dynamics curve morphology monitored by CGM is the glycemic dynamics curve of continuous glucose monitoring. The device continuously records the human blood glucose level and plots a dynamic trend graph of blood glucose changes over 24 hours. The ratio calculation module is used to calculate the protein volume ratio based on a three-step calculation method, which facilitates subsequent ratio correction. The safety correction module is used to output a basic correction ratio based on a dual-path safety mechanism, and to dynamically manage protein intake through protein upper limits and metabolic capacity grading to ensure nutritional safety.

[0024] A dynamic adjustment method for the carbohydrate protein ratio in diabetes based on metabolic capacity grading includes the following steps: Step S1: Conduct standardized tests on users based on the graded assessment module, quantify using four-dimensional monitoring indicators, and grade metabolism according to the quantification results and metabolic capacity grading standards. Step S2: Determine the user's baseline proportion through metabolic grading; then, after sequential renal function correction and obesity correction calculations, calculate the protein volume ratio based on the protein volume ratio calculation formula; the protein volume ratio calculation formula is: ; Where G is the basic proportion; This is the kidney correction factor; For obesity correction factor; Step S3: Determine the basic correction ratio based on whether carbohydrates are high-GI foods; and set the upper limit for protein based on kidney function and degree of obesity.

[0025] The standardized testing process includes the following steps: Step A1: Measure the user's baseline blood glucose before the meal. It should be noted that the test should be performed on a non-fasting basis to avoid interfering with daily life, using the pre-meal blood glucose as the baseline. Furthermore, the user must not have undergone surgery, experienced any serious complications, or had any critical medication adjustments in the short period prior to the test.

[0026] Step A2: The user consumes 50g of standardized carbohydrates and selects the type of carbohydrates they consume; high-GI carbohydrates include refined rice and steamed buns, with a GI value ranging from 72 to 78; medium-GI carbohydrates include whole-wheat steamed buns, brown rice, and mixed grain rice, with a GI value ranging from 54 to 58; low-to-medium GI carbohydrates, namely low-to-medium GI fruit carbohydrates, include nuts such as apples and berries such as strawberries, with a GI value ranging from 50 to 54. Step A3: Perform 4 hours of CGM monitoring; CGM monitoring is a medical technology that uses a sensor implanted under the skin to track changes in blood glucose levels in real time and continuously.

[0027] Step A4: Based on the CGM monitoring results, quantify the data using four-dimensional monitoring indicators; these four-dimensional monitoring indicators include the peak blood glucose increment. Time to peak (T) and AUC increment (area under the blood glucose curve) are also important metrics. Clear half-life ; Peak blood glucose increment It can reflect insulin secretion capacity and the increase in peak blood glucose levels. The calculation formula is: ; in, This refers to the peak blood glucose level after a meal; The baseline blood glucose level before meals; the CGM device monitors both the baseline blood glucose level before meals and the blood glucose level after meals; the CGM device is a continuous glucose monitoring device, a medical device that uses subcutaneous sensors to collect and analyze human blood glucose data in real time and continuously. By observing the time to peak absorption, the gastric emptying rate and carbohydrate absorption efficiency can be calculated; the formula for calculating the time to peak absorption is: ; in, This refers to the time point of the blood glucose peak. This refers to the time point at which food intake begins; the CGM timestamp identifies the time when each blood glucose measurement data point was collected in the continuous glucose monitoring system. Calculate the AUC increment using professional analysis software. Quantifying the cumulative effect of blood glucose levels exceeding baseline within a specific time period involves calculating the integral of the difference between the blood glucose level and the baseline blood glucose level over that time period, which reflects the total glucose exposure; incremental The calculation formula is: ; in, Blood glucose levels within a specific time period Baseline blood glucose level; if A positive value represents the total cumulative amount of blood sugar exceeding the baseline level; if... A negative value indicates the total deficit of blood sugar levels below baseline. The empty half-life was calculated using a nonlinear regression fitting algorithm. The empty half-life, or the time required for blood glucose to drop 50% from its peak, reflects insulin sensitivity. It should be noted that calculating the empty half-life using a nonlinear regression fitting algorithm is a standard technique used by those skilled in the art.

[0028] Step A5: Based on the results of the four-dimensional monitoring indicators in Step A4 and using the standardized comprehensive scoring formula, perform independent metabolic grading; the criteria for metabolic capacity grading include: 1. If the peak blood glucose increment is greater than 6.0 mmol / L, the time to peak (T) is greater than 2.5 hours, the area under the blood glucose curve increment is greater than 15 mmol / L·h, the blood glucose clearance half-life is greater than 60 minutes, and the metabolic score is greater than 15, then the metabolic capacity is considered to be Grade 1, which is severely abnormal. Its core characteristics are severe insulin secretion delay and significant delay in C-peptide release resistance, resulting in extremely high CGM blood glucose peak. The recommended carbon-to-protein volume ratio is 1:4. 2. If the peak blood glucose increment is 4.5-6.0 mmol / L, the time to peak is 2.0 to 2.5 hours, the area under the blood glucose curve increment is 12 to 15 mmol / L·h, the blood glucose emptying half-life is 40 to 60 minutes, and the metabolic score is 12 to 15, then the metabolic capacity is considered to be grade 2, i.e., moderately abnormal. Its core characteristics are obvious delayed insulin secretion, delayed C-peptide release, and insufficient response. The recommended carbon-to-protein volume ratio is 1:3. 3. If the peak blood glucose increment is 3.0-4.5 mmol / L, the time to peak is 1.5 to 2.0 hours, the area under the blood glucose curve increment is 9 to 12 mmol / L·h, the blood glucose clearance half-life is 25 to 40 minutes, and the metabolic score is 9 to 12, then the metabolic capacity is considered to be grade 3, i.e., mildly abnormal. Its core characteristics are mild delayed insulin secretion, lack of insulin secretion in the early phase, and compensation in the second phase. The recommended carbon-to-protein volume ratio is 1:2. IV. If the peak blood glucose increment is 1.5-3.0 mmol / L, the time to peak is 1.0 to 1.5 hours, the area under the blood glucose curve increment is 6 to 9 mmol / L·h, the blood glucose clearance half-life is 15 to 25 minutes, and the metabolic score is 6 to 9, then the metabolic capacity is considered to be level 4, i.e., the critical state. Its core characteristics are decreased insulin sensitivity, normal total insulin secretion but weakened effect, and a carbon-to-protein volume ratio of 1:1 is recommended. 5. If the peak blood glucose increment is less than 1.5 mmol / L, the time to reach peak is less than 1.0 hour, the area under the blood glucose curve increment is less than 6 mmol / L·h, the blood glucose emptying half-life is less than 15 minutes, and the metabolic score is less than 6, then the metabolic capacity is considered to be level 5, which is basically normal. Its core characteristic is that the relative functional compensation pancreatic islet function is close to normal or in a state of impaired glucose tolerance. The recommended carbon-to-protein volume ratio is 1:0.8. It should be noted that assessing the degree of delay in insulin secretion and the degree of delay in C-peptide release are standard techniques used by those skilled in the art. (The abstract...) The functions of key cells that secrete insulin are quantified into intuitive and actionable dietary intervention ratios, achieving a direct closed loop from diagnosis to treatment.

[0029] The standardized comprehensive scoring formula is as follows: ; in, The weighting of the peak blood glucose increment; This represents the increase in peak blood glucose levels. Weighting for peak time; Peak time; The weights for the AUC increment; This is the AUC increment; To clear the weight of half-life; To clear the half-life; The standardized coefficient for the AUC increment; The standardized coefficient for peak time; The standardized coefficient of AUC; The standardized factor for clearing the half-life.

[0030] In this embodiment 30%, It is 40%. It is 20%. The weighting is set at 10%; peak time is set as the highest weighting indicator because it is the most direct and sensitive CGM manifestation indicating delayed insulin secretion; the weighting of blood glucose increment is reduced because it reflects insufficient absolute insulin secretion; both are the main criteria for diagnosing insulin response disorders. It is 1.5. It is 0.5. It is 3. The value is set to 15 to scale the typical change values ​​of each indicator to a similar numerical range, making weighted calculation easier.

[0031] The calculation of the protein volume ratio in step S2 specifically includes the following steps: Step B1: Calculate the comprehensive metabolic score (Score) based on the comprehensive scoring algorithm. The comprehensive metabolic score corresponds to the metabolic capacity level in Step S1, and the baseline proportion (G) is determined based on the metabolic capacity level. The comprehensive scoring algorithm is as follows: ; in, This represents the increase in peak blood glucose levels. Peak time; This is the AUC increment; To clear the half-life; The criteria for determining the basic ratio G are as follows: If the metabolic capacity is graded as level 1, then the baseline proportion G is 5. 2. If the metabolic capacity is classified as level 2, then the baseline proportion G is 4. 3. If the metabolic capacity is classified as level 3, then the baseline proportion G is 3. IV. If the metabolic capacity is graded as level 4, then the baseline ratio G is 2. 5. If the metabolic capacity is graded as level 5, then the baseline ratio G is 1. Step B2: Adjust based on renal function. Calculate eGFR based on relevant user indicators. eGFR (glomerular filtration rate) is a key indicator used to assess whether renal function is normal and whether it can effectively excrete metabolic waste. If eGFR is less than 60, adjust the renal correction factor. The value is 0.8; if the eGFR is not less than 60, the renal correction factor is maintained. The value is 1.

[0032] Step B3: Adjust based on user obesity; if the user's MBI is greater than 28, then the obesity correction factor is applied. Set to 1.2; if MBI is not greater than 28, then the obesity correction factor is... Keep it at 1; Step B4: Calculate the protein volume ratio corresponding to 1 part carbohydrate based on the protein volume ratio calculation formula. The protein volume ratio calculation formula is: ; Where G is the basic proportion; This is the kidney correction factor; This is the obesity correction factor.

[0033] For example, if the metabolic capacity classification is level 2, the eGFR is 70, and the MBI is 25, then the basal proportion of glucose is 4.0. =1, The value is 1, resulting in a protein volume ratio of 4.0; If the metabolic capacity classification is level 1, the eGFR is 50, and the MBI is 30, then the basal proportion of glucose is 5.0. It is 0.8. The ratio was 1.2, resulting in a protein volume ratio of 4.8.

[0034] Step S3 determines whether carbohydrates are high-GI foods and establishes a basic correction ratio, specifically including the following steps: Step C1: Enter the food type; Step C2: Determine whether the food is a high-GI food; it should be noted that the determination criteria are conventional technical means used by those skilled in the art. Step C3: If the food is a high-GI food, the basic correction ratio is 1.2 times the protein volume ratio in step S2; if the food is a medium-low GI food, the basic correction ratio is 1.1 times the protein volume ratio in step S2; if the food is a medium-GI food, the basic correction ratio will remain the same as the protein volume ratio in step S2.

[0035] Step S3 sets the upper limit for protein levels, which specifically includes the following steps: Step D1: Determine the metabolic capacity level. If the metabolic capacity is level 4 or 5, the upper limit of protein is 1.2g / kg; if the metabolic capacity is level 1 to 3, proceed to step D2. Step D2: Determine if the eGFR is less than 60. If the eGFR is less than 60, the upper limit of protein is 0.8 g / kg; if the eGFR is not less than 60, the upper limit of protein is 1.0 g / kg. Step D3: Determine if the user's BMI is less than 30. If the BMI is less than 30, maintain the protein upper limit in Step D2; if the BMI is not less than 30, reduce the protein upper limit in Step D2 by 0.1g / kg.

[0036] Example 2: CGM monitoring data after user A ingested 50g of steamed bun. It was 5.8 mmol.

[0037] The glycemic dynamics curve morphology for CGM monitoring is assessed through a tiered evaluation module. Metabolic tiering is performed based on different indicator data and core characteristics, providing targeted dietary recommendations for individuals with varying metabolic capacities. A protein volume ratio calculation module eliminates the need for complex calorie calculations, simplifying the process. A safety correction module sets upper limits for protein intake based on renal function and obesity levels to prevent excessive protein intake and ensure nutritional balance. (4.0 mmol / L·h) The timeframe is 75 minutes. Analysis of user A's CGM monitoring curve shows a typical "late and high" pattern, indicating the disappearance of the first phase of insulin secretion. The pancreas's perception and response to rising blood glucose is severely delayed; insulin is only slowly released after blood glucose has reached a high level. It should be noted that the insulin secretion level is a standard technique used by those skilled in the art. Cellular function may decline, resulting in insufficient total insulin release or low efficacy, which cannot effectively lower blood sugar; therefore, the clearance half-life is relatively long. A metabolic score is calculated for user A, and the values ​​of each indicator are substituted into the comprehensive scoring formula. In this embodiment... 30%, It is 40%. It is 20%. 10%, It is 1.5. It is 0.5. It is 3. The score was 15; the final metabolic score was 4.43. Based on the various indicators, the user was classified as Level 2, with significantly delayed insulin secretion. A volume ratio of 1 part carbohydrate to 3 parts protein was recommended. The purpose of increasing the protein ratio was to utilize the dual mechanism of protein delaying gastric emptying and the insulin-secreting effect, especially the secretion-promoting effect of whey protein, to externally compensate for the user's own slow and inefficient insulin response, thereby smoothing the blood glucose curve.

[0038] Example 3 describes the process of adjusting the basic corrected protein ratio when a user consumes refined carbohydrates, fruits, or whole grains. Figure 6 As shown, it specifically includes: Step E1: Input and determine the food type; Step E2: If the food is refined carbohydrates (high GI food), use 1.2 times the user's protein volume ratio as the basic adjustment ratio; if the food is fruit (medium to low GI food), use 1.1 times the user's protein volume ratio as the basic adjustment ratio; if the food is whole grains (medium GI food), maintain the user's protein volume ratio as the basic adjustment ratio. Step E3: Determine whether the user is a high-risk group, that is, determine the user's metabolic capacity level; Step E4: If the user's metabolic capacity is classified as level 1 to 3, the basic correction ratio in step E2 is output as the final ratio; if the user's metabolic capacity is classified as level 4 or 5, the basic correction ratio of 0.9 is used as the final ratio.

[0039] When a user selects a high-GI food, the system will force a 20% increase in protein content to prevent blood sugar spikes.

[0040] The above embodiments are not intended to limit the present invention, and the present invention is not limited to the examples given above. Any changes, modifications, additions or substitutions made by those skilled in the art within the scope of the technical solution of the present invention are also within the protection scope of the present invention.

Claims

1. A dynamic adjustment system for the carbon-protein ratio in diabetes based on metabolic capacity grading, characterized in that, It includes a grading assessment module, which is used to accurately infer the user's intrinsic insulin secretion response efficiency, i.e., core characteristics, through the glycemic dynamics curve morphology monitored by CGM, and to perform metabolic grading assessment based on different indicator data and core characteristics. The ratio calculation module is used to calculate the protein volume ratio based on a three-step calculation method, which facilitates subsequent ratio correction. The safety correction module is used to output a basic correction ratio based on a dual-path safety mechanism, and to ensure nutritional safety by setting a protein upper limit and dynamically managing protein intake according to metabolic capacity classification.

2. The dynamic adjustment system for the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 1, characterized in that, The three-step calculation method includes basic ratio calculation, renal function impairment correction calculation, and obesity degree correction calculation.

3. A method for dynamically adjusting the carbohydrate-protein ratio in diabetes based on metabolic capacity grading, applied to the dynamic adjustment system for the carbohydrate-protein ratio in diabetes based on metabolic capacity grading as described in claim 2, characterized in that, Specifically, the following steps are included: Step S1: Conduct standardized tests on users based on the graded assessment module, quantify using four-dimensional monitoring indicators, and grade metabolism according to the quantification results and metabolic capacity grading standards. Step S2: Determine the user's baseline ratio through metabolic grading; Then, after undergoing renal function correction calculation and obesity correction calculation in sequence, the protein volume ratio is calculated based on the protein volume ratio calculation formula; The formula for calculating the protein volume ratio is: ； Where G is the basic proportion; This is the kidney correction factor; For obesity correction factor; Step S3: Determine the basic correction ratio based on whether carbohydrates are high-GI foods; and set the upper limit for protein based on kidney function and degree of obesity.

4. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 3, characterized in that: The standardized testing performed in step S1 specifically includes the following steps: Step A1: Measure the user's baseline blood glucose level before the user's meal; Step A2: The user consumes 50g of standardized carbohydrates and selects the type of carbohydrates they consume; Step A3: Perform 4 hours of CGM monitoring; Step A4: Based on the CGM monitoring results, quantify them using four-dimensional monitoring indicators; Step A5: Based on the results of the four-dimensional monitoring indicators in Step A4 and using the standardized comprehensive scoring formula, perform independent metabolic grading; the metabolic capacity grading criteria are as follows:

1. If the peak blood glucose increase is greater than 6.0 mmol / L, the time to peak (T) is greater than 2.5 hours, the area under the blood glucose curve increases by more than 15 mmol / L·h, and the blood glucose clearance half-life exceeds 60 minutes, then the metabolic capacity is considered to be Grade 1, i.e., severely abnormal.

2. If the peak blood glucose increase is 4.5-6.0 mmol / L, the time to reach the peak is 2.0 to 2.5 hours, the increase in the area under the blood glucose curve is 12 to 15 mmol / L·h, and the blood glucose clearance half-life is 40 to 60 minutes, then the metabolic capacity is considered to be grade 2, i.e., moderately abnormal.

3. If the peak blood glucose increase is 3.0-4.5 mmol / L, the time to reach the peak is 1.5 to 2.0 hours, the increase in the area under the blood glucose curve is 9 to 12 mmol / L·h, and the blood glucose clearance half-life is 25 to 40 minutes, then the metabolic capacity is considered to be grade 3, i.e., mildly abnormal. IV. If the peak blood glucose increment is 1.5-3.0 mmol / L, the time to reach peak is 1.0 to 1.5 hours, the area under the blood glucose curve increment is 6 to 9 mmol / L·h, and the blood glucose clearance half-life is 15 to 25 minutes, then the metabolic capacity is considered to be level 4, i.e., the critical state.

5. If the peak blood glucose increase is less than 1.5 mmol / L, the time to reach the peak is less than 1.0 hour, the increase in the area under the blood glucose curve is less than 6 mmol / L·h, and the blood glucose clearance half-life is less than 15 minutes, then the metabolic capacity is considered to be level 5, which is basically normal.

5. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 4, characterized in that: The four-dimensional monitoring indicators in step S1 include peak blood glucose increment. Time to peak (T) and AUC increment (area under the blood glucose curve) are also important metrics. Clear half-life .

6. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 5, characterized in that: The peak blood glucose increment The calculation formula is: ； in, This refers to the peak blood glucose level after a meal; This refers to the baseline blood glucose level before a meal; The formula for calculating peak time is: ； in, This refers to the time point of the blood glucose peak. This is the time to start eating; Increment The calculation formula is: ； in, Blood glucose levels within a specific time period Baseline blood glucose level.

7. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 6, characterized in that: The standardized comprehensive scoring formula in step A5 is as follows: ； in, The weighting of the peak blood glucose increment; This represents the increase in peak blood glucose levels. Weighting for peak time; Peak time; The weights for the AUC increment; This is the AUC increment; To clear the weight of half-life; To clear the half-life; The standardized coefficient for the AUC increment; The standardized coefficient for peak time; The standardized coefficient of AUC; The standardized coefficient for clearing the half-life.

8. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 7, characterized in that: The calculation of the protein volume ratio in step S2 specifically includes the following steps: Step B1: Calculate the comprehensive metabolic score (Score) based on the comprehensive scoring algorithm. The comprehensive metabolic score corresponds to the metabolic capacity level in Step S1, and the baseline proportion (G) is determined based on the metabolic capacity level. The comprehensive scoring algorithm is as follows: ； in, This represents the increase in peak blood glucose levels. Peak time; This is the AUC increment; To clear the half-life; Step B2: Adjust based on renal function, calculate eGFR based on relevant user indicators; if eGFR is less than 60, adjust the renal correction factor. The value is 0.8; if the eGFR is not less than 60, the renal correction factor is maintained. =1; Step B3: Adjust based on user obesity; if the user's MBI is greater than 28, then the obesity correction factor is applied. Set to 1.2; if MBI is not greater than 28, then the obesity correction factor is... Keep it at 1; Step B4: Calculate the protein volume ratio based on the protein volume ratio calculation formula.

9. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 8, characterized in that: Determining the basic correction ratio in step S3 specifically includes the following steps: Step C1: Enter the food type; Step C2: Determine if the food is a high-GI food; Step C3: If the food is a high-GI food, the basic correction ratio is 1.2 times the protein volume ratio in step S2; if the food is a medium-low GI food, the basic correction ratio is 1.1 times the protein volume ratio in step S2; if the food is a medium-GI food, the basic correction ratio will remain the same as the protein volume ratio in step S2.

10. The method for dynamic adjustment of the carbohydrate protein ratio in diabetes based on metabolic capacity grading according to claim 9, characterized in that: Setting the upper limit for protein levels in step S3 specifically includes the following steps: Step D1: Determine the metabolic capacity level. If the metabolic capacity is level 4 or 5, the upper limit of protein is 1.2g / kg; if the metabolic capacity is level 1 to 3, proceed to step D2. Step D2: Determine if the eGFR is less than 60. If the eGFR is less than 60, the upper limit of protein is 0.8 g / kg; if the eGFR is not less than 60, the upper limit of protein is 1.0 g / kg. Step D3: Determine if the user's BMI is less than 30. If the BMI is less than 30, maintain the protein upper limit in Step D2; if the BMI is not less than 30, reduce the protein upper limit in Step D2 by 0.1g / kg.

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