Compound lithospermum ointment for treating damp-heat dermatosis as well as preparation method and application of compound lithospermum ointment

Abstract

The invention discloses a compound lithospermum ointment for treating damp-heat dermatosis and a preparation method of the compound lithospermum ointment. The radix arnebiae seu lithospermi ointment is prepared by extracting multiple traditional Chinese medicines such as radix arnebiae seu lithospermi, radix sophorae flavescentis, dandelion, radix salviae miltiorrhizae, cortex moutan, rhizoma atractylodis, catechu and liquorice through plant oil frying and then adding beewax. The radix arnebiae seu lithospermi and the radix sophorae flavescentis are used as monarch drugs, have the effects of clearing heat, cooling blood, eliminating dampness and relieving itching, and are matched with ministerial and adjuvant drugs such as the dandelion, the radix salviae miltiorrhizae, the cortex moutan, the rhizoma atractylodis and the catechu to jointly achieve the synergistic effects of clearing heat, drying dampness, cooling blood, detoxifying, killing parasites, relieving itching, activating blood and promoting tissue regeneration; the traditional Chinese medicine is especially suitable for treating eczema, dermatitis, mosquito bite, acne, mild scald and other damp-heat accumulation type skin diseases. The medicine is remarkable in curative effect, safe to use and reasonable in preparation process.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a compound radix lithospermi ointment for treating skin diseases caused by damp-heat accumulation and a preparation method thereof. BACKGROUND

[0002] The compound radix lithospermi ointment in the current pharmacopoeia is mainly composed of radix lithospermi, angelica sinensis, saposhnikovia divaricata and radix angelicae dahuricae, which is good at promoting blood circulation and removing swelling, but is slightly inferior in drying dampness and relieving itching for skin diseases with both dampness and heat, especially acute eczema, allergic dermatitis with severe itching and exudation.

[0003] The existing products containing radix lithospermi on the market are either inclined to clearing heat and ignoring drying dampness, or inclined to relieving itching and ignoring promoting blood circulation and removing swelling, which are difficult to comprehensively and effectively treat damp-heat skin diseases.

[0004] The present application aims to solve the above problems and provide a compound radix lithospermi ointment with more balanced efficacy, especially good at clearing heat and drying dampness, killing insects and relieving itching, and also having the effects of cooling blood, detoxifying, promoting blood circulation and removing swelling. SUMMARY

[0005] The present application aims to solve the above problems and provide a compound radix lithospermi ointment with more balanced efficacy, especially good at clearing heat and drying dampness, killing insects and relieving itching, and also having the effects of cooling blood, detoxifying, promoting blood circulation and removing swelling.

[0006] TECHNICAL SOLUTION The present application adopts the following technical solution to achieve the above-mentioned purpose. The compound radix lithospermi ointment for treating damp-heat skin diseases is prepared from the following raw materials in parts by weight: Radix lithospermi 15-45 parts, sophora flavescens 10-30 parts, herba taraxaci 10-30 parts, salvia miltiorrhiza 8-24 parts, cortex moutan 8-24 parts, atractylodes 8-24 parts, catechu 5-15 parts, licorice 5-15 parts, vegetable oil 300-900 parts, and beeswax 80-240 parts.

[0007] As a preferred solution, the compound radix lithospermi ointment for treating damp-heat skin diseases is prepared from the following raw materials in parts by weight: radix lithospermi 15-30 parts, sophora flavescens 10-20 parts, herba taraxaci 10-20 parts, salvia miltiorrhiza 8-15 parts, cortex moutan 8-15 parts, atractylodes 8-15 parts, catechu 5-10 parts, licorice 5-10 parts, vegetable oil 300-600 parts, and beeswax 80-150 parts.

[0008] As a preferred option, the compound purple gromwell ointment for treating damp-heat skin diseases described above is made from the following raw materials in parts by weight: 20 parts purple gromwell, 15 parts sophora flavescens, 15 parts dandelion, 10 parts salvia miltiorrhiza, 10 parts peony bark, 10 parts atractylodes lancea, 8 parts catechu, 6 parts licorice, 400 parts vegetable oil, and 100 parts beeswax.

[0009] As a preferred embodiment, the plant oil in the above-mentioned compound comfrey ointment is one or a mixture of several of camellia oil, sesame oil, and olive oil.

[0010] The preparation method of the compound comfrey ointment of the present invention includes the following steps: (1) Heat the vegetable oil, add Atractylodes lancea, Salvia miltiorrhiza, Paeonia suffruticosa and Glycyrrhiza uralensis into the vegetable oil and fry until withered and yellow, then remove the dregs; (2) After cooling down, fry the Sophora flavescens until golden brown and remove the dregs; (3) After further cooling, add Lithospermum erythrorhizon and dandelion for low-temperature extraction; (4) Add catechu and stir to extract the flavor; (5) Filter to obtain medicinal oil, add beeswax to melt, and cool to form.

[0011] As a preferred embodiment, in the preparation method described above, the frying temperature in step (1) is 150-160°C; and the frying temperature in step (2) is 100-110°C.

[0012] As a preferred embodiment, in the preparation method described above, the extraction temperature in step (3) is 60-70°C and the extraction time is 1-12 hours; the extraction temperature in step (4) is 50-70°C and the extraction time is 1-10 hours.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: The compound purple gromwell ointment developed in this invention has a synergistic effect, and its formulation is based on the principles of traditional Chinese medicine (TCM) and its auxiliary ingredients: The principal herbs are: Lithospermum erythrorhizon, which clears heat, cools the blood, detoxifies, and promotes rash eruption; and Sophora flavescens, which clears heat, dries dampness, kills parasites, and relieves itching. Both herbs target "dampness" and "itching," and together they serve as the principal herbs.

[0014] Assistant herb: Dandelion. Dandelion clears heat and detoxifies, reduces swelling and dissipates nodules, and assists Lithospermum in strengthening its "heat-clearing" power.

[0015] Adjuvant herbs: Salvia miltiorrhiza, Paeonia suffruticosa, Atractylodes lancea, and Catechu. Salvia miltiorrhiza and Paeonia suffruticosa cool the blood and promote blood circulation; Atractylodes lancea dries dampness and strengthens the spleen; Catechu astringes dampness, promotes wound healing, and stops bleeding.

[0016] The adjuvant herb, licorice, harmonizes the effects of other herbs.

[0017] The combination of the above-mentioned herbs can achieve the organic unity of five major effects: clearing heat, drying dampness, relieving itching, promoting blood circulation, and promoting tissue regeneration.

[0018] The compound purple gromwell ointment provided by this invention has outstanding advantages: it has particularly enhanced the effects of drying dampness (sophora flavescens and atractylodes lancea) and relieving itching (sophora flavescens), and is supplemented with blood-cooling and blood-activating (salvia miltiorrhiza and peony bark). It is significantly more effective than traditional formulas for skin redness, swelling, itching and exudation (such as acute eczema) caused by damp-heat accumulation.

[0019] The compound comfrey ointment provided by this invention contains Sophora flavescens and Atractylodes lancea: both are rich in volatile oils and alkaloids, and have broad-spectrum antibacterial, antifungal and anti-inflammatory effects. Their synergistic effect can effectively inhibit pathogenic microorganisms on the skin surface.

[0020] Danshen and Mudanpi: can improve local microcirculation, promote the absorption of inflammation, and relieve redness, swelling, heat and pain.

[0021] Catechu is rich in catechins, which can effectively astringe proteins, reduce wound exudation, form a protective film, and promote healing.

[0022] Combined with other adjuvant herbs such as dandelion, salvia miltiorrhiza, peony bark, atractylodes lancea, and catechu, it works synergistically to clear heat and dry dampness, cool blood and detoxify, kill parasites and relieve itching, and promote blood circulation and tissue regeneration. It has a very good therapeutic effect on eczema, dermatitis, acne, insect bites, and burns. Specific implementation methods

[0023] The technical solution of the present invention will be clearly and completely described below with reference to specific embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Example 1 1. A compound comfrey ointment for treating damp-heat skin diseases, which is made from the following raw materials in parts by weight: 20 parts comfrey, 15 parts sophora flavescens, 15 parts dandelion, 10 parts salvia miltiorrhiza, 10 parts peony bark, 10 parts atractylodes lancea, 8 parts catechu, 6 parts licorice, 400 parts camellia oil, and 100 parts beeswax.

[0025] 2. The preparation method of the compound comfrey ointment of the present invention includes the following steps: (1) Take vegetable oil according to the weight proportions, heat the vegetable oil to 150°C, and then put Atractylodes lancea, Salvia miltiorrhiza, Paeonia suffruticosa and Glycyrrhiza uralensis into the vegetable oil and fry until withered and yellow, and remove the dregs. (2) Cool down to 110°C, take out Sophora flavescens, fry it until golden brown, and remove the dregs; (3) Continue to cool down to 60-70°C, add purple gromwell and dandelion and extract for 8 hours; (4) Add catechu and stir at 50-60°C for 6 hours to extract; (5) Filter to obtain medicinal oil, add beeswax to melt, and cool to form.

[0026] Example 2 1. A compound comfrey ointment for treating damp-heat skin diseases, which is made from the following raw materials in parts by weight: 15 parts comfrey, 10 parts sophora flavescens, 10 parts dandelion, 8 parts salvia miltiorrhiza, 8 parts peony bark, 8 parts atractylodes lancea, 5 parts catechu, 5 parts licorice, 300 parts vegetable oil, and 80 parts beeswax.

[0027] 2. The preparation method of the compound comfrey ointment of the present invention includes the following steps: (1) Take vegetable oil according to the weight proportions, heat the vegetable oil to 160°C, and then put Atractylodes lancea, Salvia miltiorrhiza, Paeonia suffruticosa and Glycyrrhiza uralensis into the vegetable oil and fry until withered and yellow, and remove the dregs. (2) Cool down to 110°C, take out Sophora flavescens, fry it until golden brown, and remove the dregs; (3) Continue to cool down to 60-70°C, add purple gromwell and dandelion and extract for 10 hours; (4) Add catechu and stir and extract at 50-60°C for 8 hours; (5) Filter to obtain medicinal oil, add beeswax to melt, and cool to form.

[0028] Example 3 1. A compound comfrey ointment for treating damp-heat skin diseases, which is made from the following raw materials in parts by weight: 30 parts comfrey, 20 parts sophora flavescens, 20 parts dandelion, 15 parts salvia miltiorrhiza, 15 parts peony bark, 15 parts atractylodes lancea, 10 parts catechu, 10 parts licorice, 600 parts vegetable oil, and 150 parts beeswax.

[0029] 2. The preparation method of the compound comfrey ointment in this embodiment is the same as that in embodiment 1.

[0030] Comparative Example 1 The purple gromwell ointment was prepared according to the method recorded in the 2000 edition of the Chinese Pharmacopoeia. The prescription was as follows: purple gromwell 500g, angelica sinensis 150g, saposhnikovia divaricata 150g, rehmannia glutinosa 150g, angelica dahurica 150g, frankincense 150g, and myrrh 150g.

[0031] The preparation method is as follows: Take the above seven ingredients, except for the gromwell root, frankincense and myrrh, grind them into a fine powder, and sift them; crush the remaining four ingredients, including angelica root, as needed. Take 6000g of edible vegetable oil, place them in a pot, and fry them until withered, then remove the residue. Moisten the gromwell root with water, place it in a pot, and fry until the oil turns purplish-red, then remove the residue and filter. Add an appropriate amount of beeswax (2-4g beeswax per 10g of vegetable oil), melt it, let it cool to a warm temperature, add the above powder, stir well, and the product is ready.

[0032] Comparative Example 2 1. A compound comfrey ointment for treating damp-heat skin diseases, made from the following ingredients in parts by weight. 50 parts of Lithospermum erythrorhizon, 10 parts of Salvia miltiorrhiza, 10 parts of Paeonia suffruticosa, 10 parts of Atractylodes lancea, 8 parts of Catechu, 6 parts of Glycyrrhiza uralensis, 400 parts of Camellia oil, and 100 parts of beeswax.

[0033] 2. The preparation method of this embodiment includes the following steps: (1) Take vegetable oil according to the weight proportions, heat the vegetable oil to 150°C, and then put Atractylodes lancea, Salvia miltiorrhiza, Paeonia suffruticosa and Glycyrrhiza uralensis into the vegetable oil and fry until withered and yellow, and remove the dregs. (2) Continue to cool down to 60-70°C, add Lithospermum erythrorhizon and extract for 8 hours; (3) Add catechu and stir at 50-60°C for 6 hours to extract; (5) Filter to obtain medicinal oil, add beeswax to melt, and cool to form.

[0034] Example 4 Pharmacodynamic Study To verify the effectiveness of the compound comfrey ointment of the present invention, a series of in vitro pharmacodynamic experiments were conducted to evaluate its efficacy in terms of antibacterial, anti-inflammatory, and antipruritic effects.

[0035] 1. In vitro antibacterial test 1.1 Experimental method: The diameter of the inhibition zone was determined using the Oxford cup method (tube disc method).

[0036] 1.2 Experimental strains: Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 8739), and Candida albicans (ATCC 10231).

[0037] 1.3 Sample preparation: The compound comfrey ointment prepared in Example 1 of this invention, the comfrey ointment of Comparative Example 1, and the comfrey ointment of Comparative Example 2 were all diluted with sterile DMSO to a concentration of 50%.

[0038] 1.4 Experimental results: as shown in Table 1 below.

[0039] Table 1: Comparison of inhibition zone diameters (mm, n=3) Group Staphylococcus aureus Escherichia coli Candida albicans Example 1 compound arnebia euchroma ointment 22.5 ±0.7 ## ]] 18.2 ± 0.5 # ]] 16.8 ± 0.4 *## ]] Comparative example 1 arnebia euchroma ointment 19.1± 0.6 16.3± 0.4 12.1± 0.4 Comparative example 2 arnebia euchroma ointment 19.5± 0.6 14.8± 0.4 11.5± 0.3 Note: Compared with the comfrey ointment of Comparative Example 1, *P < 0.05, **P < 0.01; compared with the comfrey ointment of Comparative Example 2, # P < 0.05, ## P < 0.01; The above antibacterial test results show that all three types of comfrey ointments exhibit significant inhibitory effects on common skin pathogens. However, the antibacterial effect of the compound comfrey ointment in Example 1 is better than that of the other comparative examples, indicating the synergistic antibacterial effect of comfrey, sophora flavescens, and dandelion in the formula.

[0040] 2. Anti-inflammatory experiment (mouse ear swelling model) 2.1 Experimental Methods: A xylene-induced mouse ear swelling model was used. ICR mice were randomly divided into three groups: the compound comfrey ointment group (Example 1), the comfrey ointment group (Comparative Example 1), and the comfrey ointment group (Comparative Example 2). One hour after administration, xylene was applied to both sides of the right ear of the mice to induce inflammation, while the left ear was left untreated. The mice were sacrificed 30 minutes later, and ear films were taken to calculate the degree of swelling and the swelling inhibition rate.

[0041] 2.2 Experimental results: as shown in Table 2 below.

[0042] Table 2 Effects of xylene on ear swelling in mice (n=10) Group Swelling degree (mg) Swelling inhibition rate (%) Example 1 compound arnebia euchroma ointment 8.4 ± 1.4 ** ]] 50.6% ** ]]> Comparative example 1 arnebia euchroma ointment 10.6 ± 1.8 41.5% Comparative example 2 arnebia euchroma ointment 9.0± 0.8 47.7% Note: Compared with the comfrey ointment in Comparative Example 1, *P < 0.05, **P < 0.01; The above experimental results show that the compound comfrey ointment provided by this invention can significantly inhibit xylene-induced acute inflammation of the mouse auricle, with a swelling inhibition rate (50.6%) that is higher than that of the comfrey ointment in Comparative Example 1, which is statistically significant. This indicates that the product of this invention has a stronger anti-acute inflammatory effect, thanks to the synergistic anti-inflammatory effects of ingredients such as salvia miltiorrhiza, peony bark, and licorice in the formula.

[0043] 3. Antipruritic experiment (histamine phosphate-induced itch threshold model in guinea pigs) 3.1 Experimental Methods: Guinea pigs were randomly divided into three groups: the compound comfrey ointment group of Example 1, the comfrey ointment group of Comparative Example 1, and the comfrey ointment group of Comparative Example 2. One hour later, histamine phosphate solution (0.01%) was injected into the dorsal side of the right hind foot, with the concentration increasing every 3 minutes. The total amount of histamine injected (itch threshold) was recorded when the guinea pig began to lick its foot.

[0044] 3.2 Test results: as shown in Table 3 below.

[0045] Table 3 Effect of histamine phosphate on the itch threshold in guinea pigs (n=8) Group Itching threshold (μg) Example 1 compound arnebia euchroma ointment 78.6 ± 7.5 **## ]] Comparative example 1 arnebia euchroma ointment 60.6 ± 5.6 Comparative example 2 arnebia euchroma ointment 62.8± 6.0 Note: Compared with the comfrey ointment of Comparative Example 1, *P < 0.05, **P < 0.01; compared with the comfrey ointment of Comparative Example 2, # P < 0.05, ## P < 0.01; The experimental results in Table 3 above show that the compound comfrey ointment provided by this invention can significantly increase the pruritus threshold of guinea pigs to histamine phosphate, and its effect is significantly better than that of the comparative examples. This indicates that the compound comfrey ointment of this invention has a strong antipruritic ability, which is highly correlated with the "insectic and antipruritic" effects of the principal herb Sophora flavescens and the "drying" effect of Atractylodes lancea. Removing dampness will reduce itching.

[0046] The above pharmacodynamic experimental results show that the Chinese herbs in the formula of this invention have achieved good effects in antibacterial, anti-inflammatory and antipruritic aspects through the synergistic effects of clearing heat and drying dampness (Sophora flavescens, Atractylodes lancea), cooling blood and detoxifying (Lithospermum erythrorhizon, Taraxacum mongolicum, Paeonia suffruticosa), and promoting blood circulation and removing blood stasis (Salvia miltiorrhiza).

[0047] Example 5: Clinical efficacy study of comfrey ointment in treating eczema, insect bites, and minor burns. 1. Materials and Methods 1.1 General Information Thirty patients with skin diseases admitted to the outpatient department of Jingjiang Municipal Hospital of Traditional Chinese Medicine between January and August 2025 were selected as the study subjects. There were 16 males and 14 females; their ages ranged from 5 to 65 years, with a mean age of 34.2 ± 12.6 years; the duration of illness ranged from 3 days to 3 months. Disease types included eczema (12 cases), insect bites (10 cases), and minor burns (8 cases). All patients signed informed consent forms before enrollment.

[0048] 1.2 Treatment methods All patients were treated with the compound purple gromwell ointment prepared in Example 1 of this invention.

[0049] Treatment method: External use. For patients with eczema and burns, first clean and disinfect the affected area. For patients with insect bites, apply the medication directly. Apply an appropriate amount of comfrey ointment evenly to the affected area 2-3 times daily. After application, patients with eczema and burns can cover the area with sterile gauze. The treatment period is 2 weeks.

[0050] 1.3 Observation Indicators (1) Symptom and sign score: including redness, swelling, pain, itching, exudation, etc. (2) Changes in lesion area: Measure the changes in lesion area before and after treatment. (3) Recovery time: Record the time when clinical symptoms completely disappear. (4) Adverse reactions: Observe for any allergic reactions, irritation, etc. 1.4 Efficacy Evaluation Criteria Cure: Skin lesions completely subside, symptoms completely disappear, and skin returns to normal. Significant effect: Skin lesions subside by ≥70%, and symptoms are significantly improved. Effective: Skin lesions subside in 30%–69% of cases, and symptoms improve. Ineffective: Skin lesions subside by less than 30%, symptoms do not improve or worsen. Overall effective rate (%) = (Number of cured cases + Number of cases with significant improvement + Number of cases with improvement) / Total number of cases × 100% 1.5 Statistical Methods Data analysis was performed using SPSS 26.0 software. Quantitative data were expressed as mean ± standard deviation, and paired t-tests were used to compare data before and after treatment. Categorical data were expressed as percentages (%). A p-value < 0.05 was considered statistically significant.

[0051] 2 Results 2.1 Clinical efficacy analysis As shown in Table 4, after 2 weeks of treatment, the efficacy results of 30 patients were as follows: the total effective rate was 91.7% in the eczema group, 100% in the mosquito bite group, and 87.5% in the mild burn group, with an overall total effective rate of 93.3%.

[0052] Table 4. Clinical efficacy statistics of 30 patients [n(%)] Disease type Example number Cured Effective Effective Ineffective Total effective rate Eczema 12 5(41.7%) 4(33.3%) 2(16.7%) 1(8.3%) 91.7% Mosquito bites 10 8(80.0%) 2(20.0%) 0(0.0%) 0(0.0%) 100.0% Mild burns and scalds 8 3(37.5%) 2(25.0%) 2(25.0%) 1(12.5%) 87.5% Total 30 16(53.3%) 8(26.7%) 4(13.3%) 2(6.7%) 93.3% 2.2 Symptom improvement As shown in Table 5, after treatment, the patients' VAS scores for pruritus decreased from 7.2±1.5 to 1.3±0.7 (t=16.84, P<0.01), and for pain from 6.5±1.8 to 1.2±0.6 (t=14.26, P<0.01). The degree of redness and swelling significantly improved, decreasing from grade 2.5±0.6 to grade 0.3±0.2 (t=19.37, P<0.01).

[0053] Table 5 Comparison of symptom improvement before and after treatment Observation index Before treatment After treatment t value P value Itching VAS score (points) 7.2±1.5 1.3±0.7 16.84 <0.01 Pain VAS score (points) 6.5±1.8 1.2±0.6 14.26 <0.01 Redness and swelling degree (grade) 2.5±0.6 0.3±0.2 19.37 <0.01 Exudation (grade) 1.8±0.4 0.2±0.1 21.45 <0.01 2.3 Onset time and recovery time The medication is most effective for patients with mosquito bites, with significant relief of itching within 30 minutes of application. The average recovery time for eczema patients is 9.2 ± 2.4 days, for mosquito bite patients it is 3.5 ± 1.2 days, and for minor burns it is 12.6 ± 3.1 days.

[0054] 2.4 Typical Cases Case 1: Ms. Wang, female, 28 years old. She had eczema on both wrists for more than two months, characterized by erythema, papules, exudation, and severe itching. After three days of treatment with comfrey ointment, the itching was significantly reduced. After one week, the skin lesions had subsided by 70%, and after two weeks, the skin lesions had completely disappeared, and she was assessed as cured.

[0055] Case 2: Li, male, 8 years old. Multiple mosquito bites on his right lower leg, with significant redness, swelling, and intense itching. The itching was relieved within 30 minutes of medication, the redness and swelling subsided by 80% after 24 hours, and the skin lesions completely disappeared after 3 days, and he was assessed as cured.

[0056] Case 3: Mr. Zhang, male, 42 years old. He suffered a mild burn on the back of his left hand, measuring 3cm x 2cm, with blisters, redness, swelling, and pain. After one week of treatment with comfrey ointment, the blisters subsided, the pain disappeared, and the wound was essentially healed after two weeks, which was rated as a significant effect.

[0057] 2.5 Safety Evaluation During treatment, only 2 out of 30 patients experienced mild local burning sensation, which subsided spontaneously without treatment. No other significant adverse reactions were observed. The incidence of adverse reactions was 6.7%, indicating that the comfrey ointment has good safety.

[0058] The purple gromwell ointment prepared by this invention contains purple gromwell, which has the effects of clearing heat and cooling blood, detoxifying and promoting rash eruption, and is effective for redness, swelling and pain caused by heat toxin accumulation; sophora flavescens and atractylodes lancea clear heat and dry dampness, effectively inhibiting exudation and relieving itching; dandelion and peony bark clear heat and detoxify, and have anti-inflammatory and anti-swelling effects; salvia miltiorrhiza promotes blood circulation and removes blood stasis, and improves local microcirculation; catechu astringes and heals sores, and promotes wound healing; licorice harmonizes the various herbs and has anti-inflammatory and anti-allergic effects. The entire formula is well-matched and works synergistically to clear heat and dry dampness, cool blood and detoxify, reduce swelling and relieve pain, and promote tissue regeneration and wound healing. It has significant effects on eczema, insect bites and minor burns, especially in relieving itching, reducing swelling and pain, and has a rapid onset of action and good safety, making it worthy of clinical application.

[0059] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A compound purple gromwell ointment for treating damp-heat skin diseases, characterized in that, It is made from the following ingredients in parts by weight: 15-45 parts of Lithospermum erythrorhizon, 10-30 parts of Sophora flavescens, 10-30 parts of Taraxacum mongolicum, 8-24 parts of Salvia miltiorrhiza, 8-24 parts of Paeonia suffruticosa, 8-24 parts of Atractylodes lancea, 5-15 parts of Catechu, 5-15 parts of Glycyrrhiza uralensis, 300-900 parts of vegetable oil, and 80-240 parts of beeswax.

2. The compound purple gromwell ointment for treating damp-heat skin diseases according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 15-30 parts of Lithospermum erythrorhizon, 10-20 parts of Sophora flavescens, 10-20 parts of Taraxacum mongolicum, 8-15 parts of Salvia miltiorrhiza, 8-15 parts of Paeonia suffruticosa, 8-15 parts of Atractylodes lancea, 5-10 parts of Catechu, 5-10 parts of Glycyrrhiza uralensis, 300-600 parts of vegetable oil, and 80-150 parts of beeswax.

3. The compound purple gromwell ointment for treating damp-heat skin diseases according to claim 2, characterized in that, It is made from the following ingredients in parts by weight: 20 parts gromwell root, 15 parts sophora flavescens root, 15 parts dandelion, 10 parts salvia miltiorrhiza root, 10 parts peony bark, 10 parts atractylodes lancea root, 8 parts catechu, 6 parts licorice root, 400 parts vegetable oil, and 100 parts beeswax.

4. The compound comfrey ointment according to any one of claims 1 to 3, characterized in that, The vegetable oil is one or a mixture of camellia oil, sesame oil, and olive oil.

5. The method for preparing the compound comfrey ointment according to any one of claims 1-3, characterized in that, Includes the following steps: (1) Heat the vegetable oil, add Atractylodes lancea, Salvia miltiorrhiza, Paeonia suffruticosa and Glycyrrhiza uralensis into the vegetable oil and fry until withered and yellow, then remove the dregs; (2) After cooling down, fry the Sophora flavescens until golden brown and remove the dregs; (3) After further cooling, add Lithospermum erythrorhizon and dandelion for low-temperature extraction; (4) Add catechu and stir to extract; (5) Filter to obtain medicinal oil, add beeswax to melt, and cool to form.

6. The preparation method according to claim 5, characterized in that, The frying temperature in step (1) is 150-160°C; the frying temperature in step (2) is 100-110°C.

7. The preparation method according to claim 5, characterized in that, The extraction temperature in step (3) is 60-70°C and the extraction time is 1-12 hours; the extraction temperature in step (4) is 50-70°C and the extraction time is 1-10 hours.

8. The use of the compound comfrey ointment according to any one of claims 1 to 3 in the preparation of drugs for eczema, dermatitis, and acne.

9. The use of the compound comfrey ointment according to any one of claims 1 to 3 in the preparation of medicines for mosquito bites and burns.