Traditional Chinese medicine compound aromatherapy composition capable of soothing nerves and resolving depression and preparation method of traditional Chinese medicine compound aromatherapy composition

Abstract

The traditional Chinese medicine compound aromatherapy composition is prepared from the following components in parts by weight: a nerve soothing component: 5 to 15 parts of lavender, 1 to 5 parts of jasmine, 1 to 5 parts of cortex albiziae, 1 to 5 parts of cassia twig, 1 to 5 parts of radix paeoniae alba and 1 to 5 parts of rhizoma acori graminei; and the depression-relieving component comprises the following components in parts by weight: 4-12 parts of elsholtzia, 3-9 parts of rose, 2-6 parts of eupatorium, 2-8 parts of cortex albiziae and 0.5-2 parts of radix angelicae. According to the traditional Chinese medicine compound aromatherapy composition for soothing the nerves and relieving depression, provided by the invention, the nerve soothing and depression relieving are carried out at the same time, the compatibility is rigorous, the composition is superior to single essential oil or random compound, and the synergistic effect of soothing the nerves and relieving depression is remarkable; and the components are safe, have the advantages of good stability and safety and convenience in use, and are suitable for relieving symptoms such as anxiety, depression and insomnia.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine compound, and particularly relates to a traditional Chinese medicine compound for soothing the nerves and relieving depression and a preparation method thereof. BACKGROUND

[0002] With the acceleration of modern life rhythm, people are facing increasing work and life pressure, and the incidence of emotional diseases such as anxiety, depression and insomnia continues to rise. Western medicine treatment (such as benzodiazepines, selective 5-hydroxytryptamine reuptake inhibitors, etc.) can control symptoms in the short term, but is often accompanied by drowsiness, dependence, gastrointestinal reactions and other side effects, and the patient compliance is poor.

[0003] Aromatherapy, as a natural and mild auxiliary treatment method, is increasingly favored by people through the olfactory pathway to deliver aromatic molecular signals to the brain limbic system, thereby regulating mood and autonomic nervous system. Currently, commercially available aromatherapy products mostly rely on single natural plant essential oil, such as lavender essential oil for sleep aid, rose essential oil for emotional relief, etc. However, the efficacy of single essential oil is relatively limited, and long-term use is prone to resistance. Some compound aromatherapy products often lack scientific guidance of traditional Chinese medicine theory, and the compatibility is arbitrary, which is difficult to play a synergistic effect on the complex pathogenesis of coexistence of "restlessness of heart and mind" and "stagnation of liver qi" in clinic. SUMMARY

[0004] In view of the above technical deficiencies, the present application aims to provide a traditional Chinese medicine compound for soothing the nerves and relieving depression and a preparation method thereof, so as to solve the problems mentioned in the background art.

[0005] To solve the above technical problems, the present application adopts the following technical scheme: the present application provides a traditional Chinese medicine compound for soothing the nerves and relieving depression, which comprises the following components by weight: soothing component: lavender 5-15 parts, jasmine 1-5 parts, cortex albiflorae 1-5 parts, cassia twig 1-5 parts, white peony root 1-5 parts, and aconite 1-5 parts; relieving depression component: mosla 4-12 parts, rose 3-9 parts, pellitory 2-6 parts, cortex albiflorae 2-8 parts, and white pyrethrum 0.5-2 parts.

[0006] Preferably, the composition comprises the following components by weight: soothing component: lavender 10 parts, jasmine 2 parts, cortex albiflorae 2 parts, cassia twig 2 parts, white peony root 2 parts, and aconite 2 parts; relieving depression component: mosla 8 parts, rose 6 parts, pellitory 4 parts, cortex albiflorae 4 parts, and white pyrethrum 1 part.

[0007] Preferably, the form of the composition is compound essential oil, nanoemulsion or water-soluble aromatherapy liquid; the average particle size of the nanoemulsion is 100-500 nm.

[0008] The present application also provides a preparation method of the traditional Chinese medicine compound for soothing the nerves and relieving depression, comprising the following steps: a. Raw material pretreatment: weigh each raw material, clean and select, dry at low temperature to less than 8% of water content, and crush to 40-80 mesh; b. Essential oil extraction: the raw materials of the tranquilizing component and the depression-relieving component are respectively taken as a whole, and the volatile essential oil is extracted by using the water vapor distillation method or the supercritical CO2 fluid extraction method, to obtain the essential oil of the tranquilizing component and the essential oil of the depression-relieving component respectively; c. Compounding: the essential oil of the tranquilizing component and the essential oil of the depression-relieving component obtained in step b are mixed in proportion, stirred uniformly, and aged for 7-14 days to obtain the compound essential oil.

[0009] Preferably, step d, nano-emulsification, is further included, that is, a nanoscale aromatherapy emulsion is prepared, 1-5 parts by weight of the compound essential oil prepared in step c is taken, 2-10 parts by weight of a surfactant is added, and the oil phase is dissolved by stirring at 40-60 DEG C; 85-97 parts by weight of deionized water is taken as the water phase; the oil phase is slowly added into the water phase under high-speed shearing to form a primary emulsion; and then the primary emulsion is subjected to cyclic homogenization under a pressure of 50-200 MPa for 3-10 times by using a high-pressure homogenizer to obtain the tranquilizing and depression-relieving traditional Chinese medicine compound aromatherapy nano-emulsion with a particle size distribution of 100-500 nanometers.

[0010] Preferably, the surfactant is one or more of Tween-80, polysorbate-80 and hydrogenated castor oil.

[0011] The tranquilizing and depression-relieving traditional Chinese medicine compound aromatherapy composition provided by the application can be applied to the preparation of a product for preventing or assisting in the treatment of anxiety, depression and insomnia; and the product is preferably an aromatherapy product diffused by ultrasonic atomization.

[0012] The tranquilizing and depression-relieving traditional Chinese medicine compound aromatherapy composition provided by the application has the following prescription principles: The tranquilizing component: lavender is used as the monarch drug, which is good at soothing the heart and tranquilizing the mind; the cortex forsythiae and the white peony root are used as the ministerial drugs, which can enhance the effects of relieving depression and tranquilizing the mind, nourishing blood and softening the liver; the jasmine, the cassia twig and the rhizoma of the alocasia macrorrhiza are used as the auxiliary drugs, the jasmine regulates qi and relieves depression, the cassia twig warms and unblocks the meridians to balance the medicinal properties, and the rhizoma of the alocasia macrorrhiza dissipates dampness, opens the orifices and invigorates the mind and intelligence; the combination of the drugs achieves the effects of calming, tranquilizing, and assisting in sleep;

[0013] The depression-relieving component: the herba elsholtziae is used as the monarch drug, which has the effects of sweating and relieving the exterior, dampness and the middle, and promoting the flow of qi; the rosa rugosa is used as the ministerial drug, which activates blood and qi and relieves depression; the herba eriaca, the cortex forsythiae and the radix angelicae dahuricae are used as the auxiliary drugs, the herba eriaca dissipates dampness with fragrance, the cortex forsythiae enhances the relieving depression effect of the rosa rugosa, and the radix angelicae dahuricae dispels wind and dampness, opens the orifices and relieves pain, and also has the effect of dispersing and diffusing the herba elsholtziae; the whole prescription achieves the purposes of soothing the liver and relieving depression, and promoting the flow of qi.

[0014] Both components contain Radix Albiziae, which embodies the TCM treatment thought that 'calming the mind' and'relieving depression' complement each other and are difficult to separate, and strengthens the synergistic effect of the whole prescription that 'calming the mind to help relieving depression, and relieving depression to benefit calming the mind'; the combination of the two components aims at the core pathogenesis of 'depression of the mind', and achieves treatment of both the root and the branch.

[0015] The composition can be prepared into a compound essential oil, and can be further prepared into a nanoemulsion or a water-soluble aromatherapy liquid with an average particle size of 100-500 nm by using nano technology. The nanoemulsion can improve the dispersibility and stability of the essential oil in water, and is suitable for ultrasonic atomization.

[0016] The composition provided by the application is based on the TCM 'treatment based on syndrome differentiation' theory, and can calm the mind and relieve depression simultaneously, has strict compatibility, has comprehensive and synergistic effects on complex emotional problems of modern people, is superior to single essential oil or arbitrary compound, has significant synergistic effects of calming the mind and relieving depression, and has the advantages of safety, good stability, safety and convenience in use, and is suitable for relieving symptoms such as anxiety, depression and insomnia.

[0017] The essential oil is prepared into a nanoemulsion with uniform particle size and narrow distribution by high-pressure homogenization nanometerization technology, and the solubility, stability and bioavailability of the hydrophobic essential oil in water are improved.

[0018] The nanoemulsion prepared from the components can be directly added into a water-based ultrasonic atomizer for use, reduces irritation and safety hazards, has high atomization efficiency, and releases fragrance uniformly and durably. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the application.

[0020] Embodiment 1 The raw materials are weighed: the mind-calming component: lavender 100g, jasmine 20g, Radix Albiziae 20g, Ramulus Cinnamomi 20g, Radix Paeoniae Alba 20g, Rhizoma Acori Graminei 20g; the depression-relieving component: Herba Moslae 80g, Rosa rugosa 60g, Herba Eupatorium Fortunei 40g, Radix Albiziae 40g, Radix Angelicae Dahuricae 10g.

[0021] The raw materials were cleaned and dried at 45°C to a moisture content of <8%, and then ground to 60 mesh. The raw material powders of the tranquilizing component were mixed and extracted by steam distillation for 6 hours. The distillate was collected, and after oil-water separation, about 2.3 g of the tranquilizing component essential oil was obtained. The raw material powders of the depression-relieving component were treated in the same way, and about 2.1 g of the depression-relieving component essential oil was obtained. The two kinds of essential oils were mixed, stirred uniformly, and placed in a brown glass bottle for aging in a cool place for 10 days to obtain the compound essential oil of the application.

[0022] Example 2 3.0 g of the compound essential oil prepared in Example 1, 6.0 g of Tween-80, were dissolved by stirring in a 50°C water bath as the oil phase; 91.0 g of deionized water was taken as the water phase; the oil phase was slowly added to the water phase under high-speed shearing at 12000 rpm, and emulsified for 5 minutes to obtain a primary emulsion; then the primary emulsion was introduced into a high-pressure homogenizer and homogenized for 5 cycles at a pressure of 150 MPa. The obtained emulsion was light milky white and translucent, and had an average particle size of 215 nm and a PDI of 0.17, and the system had good stability.

[0023] Example 3 The raw materials were weighed: the tranquilizing component: lavender 12 parts, jasmine 3 parts, Chinese magnolia bark 3 parts, cassia twig 3 parts, white peony root 3 parts, and pinellia 3 parts; the depression-relieving component: mosla 6 parts, rose 8 parts, pellitory 3 parts, Chinese magnolia bark 5 parts, and white anise 1.5 parts.

[0024] The essential oils were extracted and mixed according to the method of Example 1, and then 2.5 g of the compound essential oil, 7.5 g of Tween-80, and 90 g of deionized water were used to prepare a nanoemulsion by high-pressure homogenization (100 MPa, 7 times) according to the method of Example 2, and the average particle size was 190 nm.

[0025] Example 4 The raw material powders of the formula of Example 1 were weighed, and the essential oil was extracted by supercritical CO2 extraction (pressure 25 MPa, temperature 45°C), and the yield was slightly higher than that of the steam distillation method; a nanoemulsion was prepared according to the same formula and process of Example 2, and the average particle size was 200 nm; the aroma of the emulsion was closer to that of natural plants, and more heat-sensitive components were retained.

[0026] Example 5 To improve the content of effective components, the formula was adjusted to: compound essential oil 5.0 g, Tween-80 10.0 g, and deionized water 85.0 g. After high-pressure homogenization (200 MPa, 10 times), a nanoemulsion with an average particle size of 150 nm was obtained. The preparation has a high concentration and is suitable for application scenarios that require rapid effect.

[0027] Comparative Example 1 The essential oil was extracted only using the soothing component, and was prepared into a nanoemulsion by the method of Example 2 with the same ratio as Example 1. This composition only focuses on soothing, and lacks the effect of soothing the liver and relieving depression.

[0028] Comparative Example 2 The essential oil was extracted only using the relieving depression component, and was prepared into a nanoemulsion by the method of Example 2 with the same ratio as Example 1. This composition only focuses on relieving depression, and lacks the effect of soothing the heart and relieving depression.

[0029] Comparative Example 3 The lavender in the soothing component was reduced to 5 parts, and the mosla in the relieving depression component was reduced to 4 parts, and the other components were the same as Example 1. After the essential oil was extracted, a nanoemulsion was prepared by the method of Example 2.

[0030] Comparative Example 4 The compound essential oil of Example 1 was weighed at 3.0 g, Tween-80 was weighed at 6.0 g, and deionized water was weighed at 91.0 g. Only high-speed shearing emulsification was performed, and high-pressure homogenization treatment was not performed. The obtained emulsion had a large particle size (about 5-20 μm), and was prone to stratification after standing.

[0031] Comparative Example 5 The compound essential oil of Example 1 was weighed at 3.0 g, dissolved in 47.0 g of anhydrous ethanol, and then 50.0 g of deionized water was added, and mixed uniformly. The solution was transparent, but contained an organic solvent and had a stimulating nature.

[0032] Effect Example Effect Example 1: Evaluation of the soothing effect of the composition of the present application on insomnia model rats 1. Experimental animals: healthy SD rats, male, SPF level, body weight 180-220 g.

[0033] 2. Main experimental drugs: compound essential oil of Example 1, nanoemulsion of Example 2, and samples of Comparative Examples 1-5. Positive control drug: estazolam tablets (purchased on the market).

[0034] 3. Experimental method: 3.1 Establishment and identification of insomnia rat model: 3.1.1 Model establishment: The insomnia model was prepared by intraperitoneal injection of p-chlorophenylalanine. The principle is that PCPA, as an irreversible inhibitor of tryptophan hydroxylase, can significantly reduce the content of 5-hydroxytryptamine (5-HT) in the brain, thereby destroying the sleep-wake cycle and leading to insomnia. The specific operation is as follows: at 9:00-10:00 every morning, PCPA powder was prepared into a suspension with 0.5% carboxymethylcellulose sodium solution, and was intraperitoneally injected into rats at a dose of 350 mg / kg, once a day, for 2 consecutive days. The normal control group of rats was intraperitoneally injected with the same volume of solvent.

[0035] 3.1.2 Criteria for Judging Model Success: After model building is completed, the success of the model is judged by the following aspects: Macroscopic behavioral observation: Compared with the normal control group, the successful model group rats should show obvious circadian rhythm disorder, manifested as abnormally increased activity during the day (photograph period), increased excitability, irritability, sensitivity to external stimuli, dull fur, and light-colored stool.

[0036] Objective experimental verification: Quantitative verification was performed using a sodium pentobarbital synergistic hypnosis experiment (see Section 3.3). The objective criteria for model success were: compared with the normal control group, the sleep latency of rats in the model group was significantly prolonged and the sleep duration was significantly shortened (p<0.05 or p<0.01).

[0037] 3.2 Grouping and Administration: Eighty rats were randomly divided into eight groups of ten each: normal control group, model group, estazolam group (0.18 mg / kg by gavage), Example 2 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 4 group, and Comparative Example 5 group. All treatment groups received the medication after successful model establishment via ultrasonic nebulization. Each sample was added to the nebulizer water at a concentration of 0.5%, and nebulized for 30 minutes daily at a fixed time. The normal control group and model group inhaled the same amount of air under the same conditions. The intervention lasted for 7 consecutive days.

[0038] 3.3 Indicator Detection: Thirty minutes after the last administration, all rats were intraperitoneally injected with a suprathreshold dose (40 mg / kg) of sodium pentobarbital solution. The disappearance of the righting reflex for 1 minute was used as the indicator of sleep onset, and the spontaneous turning over three times within 30 seconds was used as the indicator of sleep termination.

[0039] Sleep latency: Record the time from the injection of sodium pentobarbital to the disappearance of the righting reflex.

[0040] Sleep duration: Record the time from the disappearance of the righting reflex to its spontaneous recovery.

[0041] Meanwhile, the mental state, behavior, and macroscopic signs such as fur of the rats in each group were continuously observed and recorded.

[0042] 3.4 Statistical Analysis Methods: SPSS 22.0 statistical software was used. Quantitative data were expressed as mean ± standard deviation (x̄ ± s). One-way ANOVA was used for comparisons among multiple groups, and LSD-t test was used for pairwise comparisons. p < 0.05 was considered statistically significant.

[0043] 4. Experimental Results: 4.1 Effects of sodium pentobarbital on sleep-induced sleep (Table 1) Compared with the normal control group, the model group showed a highly significant prolongation of sleep latency (p<0.01) and a highly significant shortening of sleep duration (p<0.01), indicating successful model establishment. Compared with the model group, the nanoemulsion group of Example 2 significantly shortened sleep latency and prolonged sleep duration (p<0.01), confirming the successful replication of the PCPA insomnia model. Its effect was superior to the positive drug estazolam group. Comparative Example 1 (lacking antidepressant) and Comparative Example 2 (lacking sedative) were significantly weaker than Example 2, demonstrating the synergistic necessity of the combination of sedative and antidepressant groups. Comparative Example 4 (ordinary emulsion) and Comparative Example 5 (alcohol solvent) showed the worst effects, demonstrating the advantages of nanotechnology and the importance of solvent-free formulations.

[0044] Table 1: Results of the sodium pentobarbital synergistic hypnosis experiment in rats of each group (x̄ ± s, n=10) Table 1 Note: Compared with the normal control group, ##p<0.01; compared with the model group, *p<0.05, **p<0.01.

[0045] 4.2 Macroscopic observation: After PCPA injection, rats in the model group exhibited symptoms such as hyperactivity, irritability, dull yellow fur, and slow weight gain. Rats in Example 2 group showed calm behavior, glossy fur, and their weight recovered to near normal levels. The behavioral improvement in Comparative Example 1 and Comparative Example 2 groups was less than that in Example 2 group. The improvement in physical signs was not significant in Comparative Example 4 and Comparative Example 5 groups.

[0046] Example 2: Evaluation of the depressive effect of the composition of the present invention on an anxiety and depression model mouse. 1. Laboratory animals: Healthy male ICR mice, 18-22g.

[0047] 2. Experimental Methods: 2.1 Grouping and Administration: A mouse model of depression was established using the Chronic Unpredictable Mild Stress (CUMS) method. Simultaneously with model establishment, the mice were divided into groups for intervention (same as in Effect Example 1, n=12). The treatment group received the medication via nebulized inhalation (0.5% concentration, 30 minutes daily) for 4 consecutive weeks.

[0048] 2.2 Behavioral testing: Opening test: One hour after the last dose, mice were placed in the center of the opening test box, and their total distance traveled and time spent in the central area were recorded over 5 minutes. Their spontaneous activity and exploratory behavior (reflecting anxiety) were evaluated.

[0049] Tail suspension test: The tail of a mouse is fixed and it is suspended upside down. The immobility time in the last 4 minutes of a 6-minute test is recorded. A shorter immobility time reflects an antidepressant-like effect.

[0050] 2.3 Statistical Analysis: Same as Example 1.

[0051] 3. Experimental Results: 3.1 Opening Experiment Results (Table 2): Compared with the normal control group, the model group mice showed a significant reduction in activity time and total distance traveled in the central region (p<0.01), indicating anxiety-like behavior. Compared with the model group, the nanoemulsion group of Example 2 significantly increased activity time and total distance traveled in the central region (p<0.01). Comparative Example 1 was less effective than Example 2 in increasing activity time in the central region (p<0.05), while Comparative Example 2 showed no significant improvement in total distance traveled.

[0052] Table 2: Results of the opening experiment (x̄ ± s, n=12) Table 2 Note: ##p<0.01 vs normal group; *p<0.05, **p<0.01 vs model group.

[0053] 3.2 Results of the tail suspension test (Table 3): Compared with the normal control group, the immobility time of mice in the model group was significantly prolonged (p<0.01). Compared with the model group, the nanoemulsion group of Example 2 significantly shortened the immobility time (p<0.01). The effect of Comparative Example 2 in shortening the immobility time was weaker than that of Example 2 (p<0.05), and the improvement of Comparative Example 1 was not obvious.

[0054] Table 3: Time of immobility in the tail suspension experiment (x̄ ± s, n=12, unit: s) Table 3 Note: ##p<0.01 vs normal group; *p<0.05, **p<0.01 vs model group.

[0055] Therefore, it can be seen that the composition of the present invention has clear anti-anxiety and anti-depressant effects, and the effect of the complete formulation is better than that of the comparative formulation with missing components, which verifies the scientific nature and synergistic effect of the compound formulation of the present invention.

[0056] Example 3: Clinical efficacy observation 1. General Information: 120 patients diagnosed with mild to moderate anxiety and insomnia at a hospital outpatient clinic from June 2023 to May 2024 were randomly divided into 4 groups, with 30 patients in each group. There were no statistically significant differences among the four groups in terms of age, gender, duration of illness, and PSQI (Pittsburgh Sleep Quality Index) and HAMA (Hamilton Anxiety Scale) scores (p>0.05), making them comparable.

[0057] 2. Treatment methods: Group A (the group of the present invention): Use the nano aromatherapy emulsion prepared in Example 2, add it to a dedicated ultrasonic nebulizer, and atomize and diffuse it in the bedroom for 1 hour every night before going to bed.

[0058] Group B (traditional essential oil group): Use the compound essential oil prepared in Example 1, and add it to a common aromatherapy machine that requires adding water and has no nanotechnology for use.

[0059] Group C (control group 4): Use the ordinary emulsion prepared in Comparative Example 4, and add it to an ultrasonic nebulizer for use.

[0060] Group D (blank control group): Only conduct lifestyle guidance and do not use any aromatherapy products.

[0061] The treatment course for all groups is 4 weeks.

[0062] 3. Observation indicators: PSQI score and HAMA score before and after treatment. Criteria for efficacy determination: Recovery: PSQI reduction rate > 75%; Marked effect: 50% < PSQI reduction rate ≤ 75%; Effective: 25% < PSQI reduction rate ≤ 50%; Ineffective: PSQI reduction rate ≤ 25%. Total effective rate = (recovery + marked effect + effective) / number of cases × 100%.

[0063] 4. Results: 4.1 Comparison of clinical efficacy (Table 4) The total effective rate of the group of the present invention (Group A) is significantly higher than that of other groups (p < 0.05).

[0064] Table 4: Comparison of clinical efficacy of four groups of patients [n(%)] <00,00174> Table 4 Note: Compared with Groups B, C, and D, ▲p < 0.​​​​​​​​​​​​​​​​The above animal experiments and clinical research data show that the traditional Chinese medicine compound aromatherapy composition provided by the present invention, with its nano-level emulsion dosage form and ultrasonic atomization, has significant dual effects of calming the nerves and relieving depression, and its effects are superior to traditional essential oil formulas and non-nano-based preparations.

[0068] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A compound aromatherapy composition of traditional Chinese medicine for calming the nerves and relieving depression, characterized in that, It includes the following components by weight: sedative components: lavender 5-15 parts, jasmine 1-5 parts, albizia bark 1-5 parts, cinnamon twig 1-5 parts, white peony root 1-5 parts, and acorus tatarinowii 1-5 parts; depressive components: euphorbia pekinensis 4-12 parts, rose 3-9 parts, eupatorium fortunei 2-6 parts, albizia bark 2-8 parts, and angelica dahurica 0.5-2 parts.

2. The aromatherapy composition of traditional Chinese medicine for calming the nerves and relieving depression as described in claim 1, characterized in that, The formula includes the following components by weight: sedative components: 10 parts lavender, 2 parts jasmine, 2 parts albizia bark, 2 parts cinnamon twig, 2 parts white peony root, 2 parts acorus tatarinowii; depressant components: 8 parts euphorbia pekinensis, 6 parts rose, 4 parts eupatorium fortunei, 4 parts albizia bark, 1 part angelica dahurica.

3. The aromatherapy composition of traditional Chinese medicine for calming the nerves and relieving depression as described in claim 1, characterized in that, The composition is in the form of compound essential oil, nanoemulsion, or water-soluble aromatherapy liquid; the average particle size of the nanoemulsion is 100-500 nm.

4. The preparation method of the sedative and mood-relieving traditional Chinese medicine compound aromatherapy composition as described in claim 1, characterized in that, Includes the following steps: a. Raw material pretreatment: Weigh each raw material, clean and select it, dry it at low temperature until the moisture content is less than 8%, and then crush it to 40-80 mesh; b. Essential oil extraction: The raw materials of the calming component and the depression-relieving component are treated as whole, and their volatile essential oils are extracted by steam distillation or supercritical CO2 fluid extraction to obtain the calming component essential oil and the depression-relieving component essential oil, respectively. c. Compounding: Mix the calming component essential oil and the depression-relieving component essential oil obtained in step b in a certain proportion, stir evenly, and let stand and age for 7-14 days to obtain the compound essential oil.

5. The preparation method of the sedative and mood-relieving traditional Chinese medicine compound aromatherapy composition as described in claim 4, characterized in that, The process also includes step d, nanoemulsification: preparing a nano-sized aromatherapy emulsion by taking 1-5 parts by weight of the compound essential oil obtained in step c, adding 2-10 parts by weight of a surfactant, and stirring and dissolving it at 40-60℃ to form an oil phase; taking 85-97 parts by weight of deionized water as an aqueous phase; slowly adding the oil phase to the aqueous phase under high-speed shearing to form a primary emulsion; then homogenizing the primary emulsion by circulating it 3-10 times under a high-pressure homogenizer at a pressure of 50-200 MPa to obtain a calming and mood-relieving traditional Chinese medicine compound aromatherapy nanoemulsion with a particle size distribution of 100-500 nanometers.

6. The preparation method of the sedative and mood-relieving traditional Chinese medicine compound aromatherapy composition as described in claim 5, characterized in that, The surfactant is one or more of Tween-80, polysorbate-80, and hydrogenated castor oil.

7. The aromatherapy composition of traditional Chinese medicine for calming the nerves and relieving depression as described in claim 1, characterized in that, It is used in the preparation of products for the prevention or adjunctive treatment of anxiety, depression, and insomnia.

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