Inhalation device for monitoring drug concentration in real time and dosage regulation and control method

Abstract

The invention relates to the technical field of medical instruments, in particular to an inhalation device for monitoring drug concentration in real time and a dose regulation and control method.The inhalation device comprises a bottom plate and a dry powder storage tank installed on the bottom plate, a fixing block is installed at the top end of the dry powder storage tank, and an inhalation pipe connected into the dry powder storage tank is embedded into the fixing block; a gas storage tank is installed on one side of the top end of the bottom plate, a connecting pipeline is connected between the gas storage tank and the dry powder storage tank, a gas inlet pipe connected to the rear end of the suction pipe is embedded in the top end of the gas storage tank, and a gas pump is installed on the side, close to the fixing block, of the top end of the dry powder storage tank. The air guide pipe is connected to a flow dividing pipe at the inner end of the fixing block, a plurality of injection pipes extending to the inner pipe wall of the suction pipe are embedded in the flow dividing pipe, an air bag cavity is formed in the suction pipe, and a plurality of reinforcing ribs are fixedly connected to the inner end of the air bag cavity. The pipe diameter of the suction pipe is enlarged, and concentration is reduced.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to an inhalation device for real-time monitoring of drug concentration and a dosage control method. Background Technology

[0002] In the treatment of respiratory diseases (such as asthma and chronic obstructive pulmonary disease), drug inhalation is an important method of drug delivery, with drug forms including dry powder and nebulizers. Inhalation allows drugs to act directly on the affected areas of the respiratory tract, resulting in faster onset of action and reducing systemic side effects compared to oral administration.

[0003] Currently, most inhalation devices only control the total amount of gas inhaled, failing to directly affect the drug concentration within the inhalation tube. This can easily lead to excessively high local drug concentrations within the tube, affecting dosing accuracy and potentially causing adverse reactions. Furthermore, as dry powder medications flow through the inhalation tube, frequent static electricity is generated due to friction between particles and with the tube wall. This not only causes drug particles to adhere to the tube wall, wasting efficacy, but also alters the actual delivered concentration, further exacerbating dosage deviations and impacting therapeutic efficacy and safety. Therefore, it is necessary to develop inhalation devices and dosage control methods that allow for real-time monitoring of drug concentration. Summary of the Invention

[0004] To address the problems in the prior art, this invention provides an inhalation device for real-time monitoring of drug concentration and a dosage control method.

[0005] The technical solution adopted by the present invention to solve its technical problem is: an inhalation device for real-time monitoring of drug concentration, including a base plate and a dry powder storage tank installed on the base plate, a fixing block installed on the top of the dry powder storage tank, an inhalation tube connected to the dry powder storage tank embedded in the fixing block, and a concentration monitoring component provided at the front end of the inhalation tube wall; A gas storage tank is installed on one side of the top of the base plate. A connecting pipe is connected between the gas storage tank and the dry powder storage tank. A pump body is installed on the connecting pipe near the gas storage tank. An air inlet pipe connected to the rear end of the suction pipe is embedded in the top of the gas storage tank. An air pump is installed on the top of the dry powder storage tank near the fixed block. An air guide pipe is fixedly connected to the output end of the air pump. The air guide pipe is connected to a split pipe at the inner end of the fixed block. Several injection pipes extending to the inner wall of the suction pipe are embedded in the split pipe. The inhalation tube has an air bladder cavity inside. Several reinforcing ribs are fixedly connected to the inner end of each air bladder cavity. A contraction air bladder is set between two adjacent reinforcing ribs. The bottom surface of the contraction air bladder is connected to the bottom surface of the air bladder cavity. There is a movable gap between the top surface of the contraction air bladder and the top surface of the air bladder cavity. Branch reinforcing ribs are embedded inside the bottom surface of each contraction air bladder.

[0006] Specifically, a feed pipe is embedded at the top of the dry powder storage tank.

[0007] Specifically, a controller is installed on the outer wall of the dry powder storage tank, a mask is connected to one end of the inhalation tube, a connector is fixedly connected to the outer end of the mask for breathing, and a dry powder inhalation air pump is installed at one end of the connector.

[0008] Specifically, the mask is fitted with head restraint straps on both sides.

[0009] Specifically, an inlet and outlet pipe is embedded in the lower end of the gas storage tank wall, and the inlet pipe is a one-way valve pipe.

[0010] Specifically, the inhalation tube, reinforcing ribs, and branch reinforcing ribs are all made of medical-grade PVC, and the inhalation tube is provided with a sealing layer and an anti-static layer from the inside out.

[0011] Specifically, the concentration monitoring component includes a housing, which houses an integrated laser, a laser scatterer with a particle size screening baffle, and a photoelectric sensor.

[0012] A dosage control method for real-time monitoring of drug concentration includes the following steps: S1, the gas storage tank is connected to the pump body through a connecting pipe to fill the dry powder storage tank with inert gas, so that the dry powder in the dry powder storage tank is in a suspended and dispersed state, in preparation for subsequent uniform inhalation. S2, the patient puts on the mask and starts the dry powder inhalation pump. Under the action of the dry powder inhalation pump, the dry powder in the dry powder storage tank is inhaled through the inhalation tube and flows towards the mask. S3, synchronously start the concentration monitoring component. This component uses a built-in integrated laser, a laser scatterer of the particle size screening baffle and a photoelectric sensor to monitor the concentration of dry powder in the inhalation tube in real time and transmit the monitored concentration signal to the controller. S4. When the controller receives a high concentration signal from the concentration monitoring component, it issues an alarm and simultaneously regulates the operation of relevant components, reducing the gas flow rate into the dry powder storage tank and adjusting the operating parameters of the dry powder inhalation pump. Furthermore, the controller controls the pump to draw air into the distribution and injection pipes, causing the contraction bladder to contract. This contraction expands the bottom of the bladder cavity outwards, increasing the diameter of the inhalation tube. This increased diameter not only reduces the concentration of the dry powder but also reduces friction between powder particles, thus lowering static electricity. Simultaneously, the expanded space triggers the one-way valve in the inlet pipe to open, injecting a certain amount of inert gas into the inhalation tube, further reducing the static electricity on the powder particles and ensuring a stable and safe state during delivery, achieving precise control of drug dosage and delivery environment.

[0013] The beneficial effects of this invention are as follows: This invention constitutes a dynamic control system through components such as an air pump, a contractile air bladder, and an inlet tube. When the controller detects an abnormal concentration, it can adjust the working state of the air pump to cause the contractile air bladder to contract, thereby increasing the diameter of the inhalation tube and reducing the concentration. At the same time, it triggers the one-way valve of the inlet tube to inject inert gas, reducing static electricity generated by friction of dry powder particles. In addition, the inhalation tube is made of medical-grade PVC material and has a sealing layer and an anti-static layer structure. With the support of reinforcing ribs and branch reinforcing ribs, it not only avoids drug adsorption loss but also ensures the structural stability and sealing safety of the device during the concentration control process. At the same time, the inlet and outlet pipes of the gas storage tank can realize pressure regulation, further improving the operational reliability of the device. Attached Figure Description

[0014] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0015] Figure 1 Schematic diagram of the inhalation device for real-time monitoring of drug concentration provided by the present invention Figure 1 ; Figure 2 Schematic diagram of the inhalation device for real-time monitoring of drug concentration provided by the present invention Figure 2 ; Figure 3 The inhalation device for real-time monitoring of drug concentration provided by the present invention Figure 2 Enlarged structural diagram at point A in the middle; Figure 4 A schematic cross-sectional view of the inhalation tube of the inhalation device for real-time monitoring of drug concentration provided by the present invention; Figure 5 A cross-sectional plan view of the inhalation tube portion of the inhalation device for real-time monitoring of drug concentration provided by the present invention; Figure 6 A schematic diagram of the branched reinforcing rib planar structure of the inhalation device for real-time monitoring of drug concentration provided by the present invention.

[0016] In the diagram: 1. Base plate; 11. Dry powder storage tank; 3. Fixing block; 31. Suction pipe; 310. Concentration monitoring component; 2. Gas storage tank; 21. Connecting pipe; 23. Air inlet pipe; 5. Air pump; 510. Air guide pipe; 51. Injection pipe; 301. Airbag cavity; 311. Reinforcing rib; 52. Contracting airbag; 53. Branch reinforcing rib; 12. Feed pipe; 10. Controller; 4. Mask; 41. Connector; 42. Dry powder suction air pump; 22. Inlet and outlet pipes; 312. Sealing layer; 313. Antistatic layer. Detailed Implementation

[0017] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0018] like Figures 1-6 As shown, the present invention provides the following technical solution: Example 1: An inhalation device for real-time monitoring of drug concentration includes a base plate 1 and a dry powder storage tank 11 mounted on the base plate 1. A fixing block 3 is installed at the top of the dry powder storage tank 11. An inhalation tube 31 connected to the dry powder storage tank 11 is embedded in the fixing block 3. A concentration monitoring component 310 is set at the front end of the inhalation tube 31. An infeed tube 12 is embedded at the top of the dry powder storage tank 11. A controller 10 is installed on the outer wall of the dry powder storage tank 11. A mask 4 is connected to one end of the inhalation tube 31. A connector 41 is fixedly connected to the outer end of the mask 4. A dry powder inhalation air pump 42 is installed at one end of the connector 41. Head restraint straps are connected to both sides of the mask 4.

[0019] Dry powder can be added to the dry powder storage tank 11 through the feed pipe 12; The drug delivery dynamics (dry powder inhalation pump 42) and concentration monitoring and control carrier (controller 10) are clearly defined to improve the core components of the drug delivery system; The restraint straps installed on both sides of the mask 4 allow the mask 4 to be worn.

[0020] In use, open the sealing cap of the feed tube 12, inject the preset dose of dry powder medication into the dry powder storage tank 11, and then seal it. The patient wears the mask 4 and adjusts it to a tight seal against the face using the head strap. The dry powder inhalation air pump 42 is then activated, and the negative pressure generated drives the dry powder in the dry powder storage tank 11 to flow along the inhalation tube 31 toward the mask 4, thus achieving inhalation drug delivery. Simultaneously, the concentration monitoring component 310 is activated, and its built-in detection unit collects the dry powder concentration signal in the inhalation tube 31 in real time. After processing, the signal is transmitted to the controller 10, and the controller 10 displays the concentration data in real time on its screen, facilitating dynamic monitoring of the drug delivery process and ensuring dosage accuracy.

[0021] Example 2: The technical solution of this example, which differs from that of Example 1, includes: a gas storage tank 2 is installed on one side of the top of the base plate 1, a connecting pipe 21 is connected between the gas storage tank 2 and the dry powder storage tank 11, and a pump body is provided on the side of the connecting pipe 21 near the gas storage tank 2. An air inlet pipe 23 connected to the rear end of the suction pipe 31 is embedded in the top of the gas storage tank 2. An air pump 5 is installed on the top of the dry powder storage tank 11 near the fixed block 3. An air guide pipe 510 is fixedly connected to the output end of the air pump 5, and the air guide pipe 510 is connected to the diversion pipe at the inner end of the fixed block 3. Several injection pipes 51 extending to the inner wall of the suction pipe 31 are embedded in the diversion pipe respectively. The inhalation tube 31 has an air bladder cavity 301 inside. Several reinforcing ribs 311 are fixedly connected to the inner end of the air bladder cavity 301. A contraction air bladder 52 is set between two adjacent reinforcing ribs 311. The bottom surface of the contraction air bladder 52 is connected to the bottom surface of the air bladder cavity 301. There is a movable gap between the top surface of the contraction air bladder 52 and the top surface of the air bladder cavity 301. Branch reinforcing ribs 53 are embedded in the bottom surface of the contraction air bladder 52. An inlet and outlet pipe 22 is embedded in the lower end of the gas storage tank 2. The inlet pipe 23 is a one-way valve pipe. The inhalation tube 31, reinforcing ribs 311 and branch reinforcing ribs 53 are all made of medical grade PVC. The inhalation tube 31 is provided with a sealing layer 312 and an antistatic layer 313 from the inside to the outside. The concentration monitoring component 310 includes a shell. The shell integrates a laser, a laser scatterer with a particle size screening baffle and a photoelectric sensor.

[0022] The operating principle of the concentration monitoring component 310 is as follows: the laser emits a laser of a specific wavelength, which penetrates the dry powder flow field inside the inhalation tube 31; when the laser encounters dry powder particles, it is scattered, and the particle size screening baffle filters out the interfering scattered light from particles of non-target particle size; the remaining scattered light is captured by the laser scatterer, and then the photoelectric sensor converts the light signal into an electrical signal, which is transmitted to the controller 10; the controller 10 calculates and outputs the drug concentration in the inhalation tube in real time by analyzing the intensity of the electrical signal (which is positively correlated with the particle concentration); The intake and exhaust pipe 22 can inject gas into the gas storage tank 2, and the one-way valve passage of the intake pipe 23 ensures that when the suction pipe 31 expands, gas will be injected into the interior of the suction pipe 31 through the one-way valve of the intake pipe 23. The inhalation tube 31, reinforcing rib 311, and branch reinforcing rib 53 are made of medical-grade PVC material, and the sealing layer 312 and antistatic layer 313 structure of the inhalation tube 31 take into account medical safety, sealing and antistatic properties, and reduce drug loss and static interference.

[0023] In use, the dry powder drug is injected into the dry powder storage tank 11 through the feed pipe 12 and then sealed. The valve of the gas storage tank 2 is opened, and the pump on the connecting pipe 21 is started to fill the dry powder storage tank 11 with inert gas, so that the dry powder is in a suspended and dispersed state to avoid particle agglomeration. After the patient wears the mask 4 and is fixed with the restraint strap, the dry powder inhalation air pump 42 is started. Under the action of negative pressure, the suspended dry powder flows along the inhalation tube 31 to the mask 4. The concentration monitoring component 310 is started at the same time. The laser emitted by the laser is filtered by the particle size screening baffle and then irradiates the dry powder particles. The laser scatterer captures the scattered light signal, and the photoelectric sensor converts the light signal into an electrical signal and transmits it to the controller 10 to realize real-time concentration monitoring.

[0024] When the controller 10 detects that the concentration exceeds the preset threshold, it immediately triggers a control command: on the one hand, it adjusts the power of the dry powder suction air pump 42 to reduce the suction flow rate; on the other hand, it starts the air pump 5 to draw gas from the contraction air bladder 52 through the air guide pipe 510, the diverter pipe and the injection pipe 51, causing the contraction air bladder 52 to contract axially, driving the bottom end of the air bladder cavity 301 to expand outward, thereby increasing the effective flow diameter of the suction pipe 31 and reducing the local dry powder concentration; at the same time, the negative pressure generated by the expansion of the pipe diameter triggers the one-way valve of the air inlet pipe 23 to open, and the inert gas in the gas storage tank 2 is injected into the suction pipe 31 through the air inlet pipe 23 to further dilute the concentration and suppress the static electricity generation of dry powder particles; the reinforcing rib 311 and the branch reinforcing rib 53 together ensure the structural stability of the suction pipe 31 in the expanded state, the sealing layer 312 prevents gas leakage, and the antistatic layer 313 reduces particle adsorption loss; when the pressure in the gas storage tank 2 is too high, the excess gas can be discharged through the air inlet and outlet pipes 22 to ensure the safe and stable operation of the device.

[0025] A dosage control method for real-time monitoring of drug concentration includes the following steps: S1, the gas storage tank 2 is connected to the pump body through the connecting pipe 21 to fill the dry powder storage tank 11 with inert gas, so that the dry powder in the dry powder storage tank 11 is in a suspended and dispersed state, in preparation for subsequent uniform inhalation. S2, the patient puts on the mask 4 and starts the dry powder inhalation pump 42. Under the action of the dry powder inhalation pump 42, the dry powder in the dry powder storage tank 11 is inhaled through the inhalation tube 31 and flows towards the mask 4. S3, synchronously start the concentration monitoring component 310. This component uses a built-in integrated laser, a laser scatterer of a particle size screening baffle and a photoelectric sensor to monitor the concentration of dry powder in the inhalation tube 31 in real time and transmit the monitored concentration signal to the controller 10. S4, when the controller 10 receives a high concentration signal from the concentration monitoring component 310, it issues an alarm and simultaneously regulates the operation of relevant components, reducing the gas flow rate into the dry powder storage tank 11 and adjusting the operating parameters of the dry powder inhalation air pump 42. Furthermore, the controller 10 controls the air pump 5 to draw air into the diversion pipe and injection pipe 51, causing the contraction airbag 52 to contract. The contraction of the contraction airbag 52 causes the bottom end of the airbag cavity 301 to expand outwards, thereby increasing the diameter of the inhalation pipe 31. This increased diameter not only reduces the concentration of the dry powder but also reduces friction between the dry powder particles, thus lowering static electricity. Simultaneously, the expanded space triggers the one-way valve of the air inlet pipe 23 to open, injecting a certain amount of inert gas into the inhalation pipe 31, further reducing the static electricity carried by the dry powder particles and ensuring a stable and safe state of the dry powder during delivery, achieving precise control of drug dosage and delivery environment.

[0026] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of protection claimed by the present invention. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. An inhalation device for real-time monitoring of drug concentration, comprising a base plate (1) and a dry powder storage tank (11) installed on the base plate (1), wherein a fixing block (3) is installed at the top of the dry powder storage tank (11), and an inhalation tube (31) connected to the dry powder storage tank (11) is embedded in the fixing block (3), and a concentration monitoring component (310) is provided at the front end of the inhalation tube (31). Its features are, A gas storage tank (2) is installed on one side of the top of the base plate (1). A connecting pipe (21) is connected between the gas storage tank (2) and the dry powder storage tank (11). A pump body is provided on the side of the connecting pipe (21) near the gas storage tank (2). An air inlet pipe (23) connected to the rear end of the suction pipe (31) is embedded at the top of the gas storage tank (2). An air pump (5) is installed on the side of the top of the dry powder storage tank (11) near the fixed block (3). An air guide pipe (510) is fixedly connected to the output end of the air pump (5). The air guide pipe (510) is connected to the diversion pipe at the inner end of the fixed block (3). Several injection pipes (51) extending to the inner wall of the suction pipe (31) are embedded on the diversion pipe. The inhalation tube (31) has an air bladder cavity (301) inside. Several reinforcing ribs (311) are fixedly connected to the inner end of the air bladder cavity (301). A contraction air bladder (52) is provided between two adjacent reinforcing ribs (311). The bottom surface of the contraction air bladder (52) is connected to the bottom surface of the air bladder cavity (301). There is a movable gap between the top surface of the contraction air bladder (52) and the top surface of the air bladder cavity (301). Branch reinforcing ribs (53) are embedded in the bottom surface of the contraction air bladder (52).

2. The inhalation device for real-time monitoring of drug concentration according to claim 1, characterized in that: The top of the dry powder storage tank (11) is embedded with a feed pipe (12).

3. The inhalation device for real-time monitoring of drug concentration according to claim 1, characterized in that: The outer wall of the dry powder storage tank (11) is equipped with a controller (10), one end of the inhalation tube (31) is connected to a mask (4), the outer end of the mask (4) is fixedly connected to a connector (41), and one end of the connector (41) is equipped with a dry powder inhalation air pump (42).

4. The inhalation device for real-time monitoring of drug concentration according to claim 3, characterized in that: The mask (4) is worn with head restraint straps on both sides.

5. The inhalation device for real-time monitoring of drug concentration according to claim 1, characterized in that: The gas storage tank (2) has an inlet and outlet pipe (22) embedded in the lower end of the tank wall, and the inlet pipe (23) is a one-way valve pipe.

6. The inhalation device for real-time monitoring of drug concentration according to claim 1, characterized in that: The inhalation tube (31), reinforcing rib (311) and branch reinforcing rib (53) are all made of medical grade PVC, and the inhalation tube (31) is provided with a sealing layer (312) and an antistatic layer (313) from the inside to the outside.

7. The inhalation device for real-time monitoring of drug concentration according to claim 1, characterized in that: The concentration monitoring component (310) includes a housing, which houses an integrated laser, a laser scatterer with a particle size screening baffle, and a photoelectric sensor.

8. A dosage control method based on real-time monitoring of drug concentration according to any one of claims 1-7, characterized in that, Includes the following steps: S1, the gas storage tank (2) is connected to the pump body through the connecting pipe (21) to fill the dry powder storage tank (11) with inert gas, so that the dry powder in the dry powder storage tank (11) is in a suspended and dispersed state, in preparation for subsequent uniform inhalation; S2, the patient puts on the mask (4), starts the dry powder inhalation pump (42), and under the action of the dry powder inhalation pump (42), the dry powder in the dry powder storage tank (11) is inhaled through the inhalation tube (31) and flows towards the mask (4); S3, synchronously start the concentration monitoring component (310). This component uses the built-in integrated laser, the laser scatterer of the particle size screening baffle and the photoelectric sensor to monitor the concentration of dry powder in the inhalation tube (31) in real time and transmit the monitored concentration signal to the controller (10). S4, when the controller (10) receives a high concentration signal transmitted by the concentration monitoring component (310), it issues an alarm; on the other hand, the controller (10) regulates the operation of relevant components, reduces the flow rate of gas into the dry powder storage tank (11), and adjusts the operating parameters of the dry powder inhalation pump (42). Furthermore, the controller (10) controls the air pump (5) to draw air into the diversion pipe and the injection pipe (51), causing the contraction airbag (52) to contract. The contraction of the contraction airbag (52) causes the bottom end of the airbag cavity (301) to expand outward, thereby increasing the diameter of the inhalation pipe (31). After the pipe diameter is increased, not only can the concentration of dry powder be reduced, but the increased space also reduces the friction between dry powder particles, and the static electricity is reduced accordingly. At the same time, the expanded space will trigger the one-way valve of the air inlet pipe (23) to open, injecting a certain amount of inert gas into the inhalation pipe (31), further reducing the static electricity carried by the dry powder particles, ensuring that the dry powder remains stable and safe during transportation, and achieving precise control of drug dosage and transportation environment.

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