Traditional Chinese medicine composition for treating spleen deficiency and damp-heat type ulcerative colitis

Abstract

The invention aims to provide a traditional Chinese medicine composition for treating spleen deficiency and damp-heat type ulcerative colitis. The traditional Chinese medicine composition can effectively solve the medication problem of the spleen deficiency and damp-heat type ulcerative colitis. The traditional Chinese medicine is prepared from bighead atractylodes rhizome, radix paeoniae alba, white poria, rhizoma alismatis, coptis chinensis, scutellaria baicalensis, humifuse euphorbia herb, smoked plum, mangnolia officinalis and liquorice, and is prepared by the following steps: soaking in water, boiling with strong fire, decocting with slow fire and filtering to obtain filtrate; adding water into filter residues, boiling with strong fire, decocting with slow fire, filtering, removing the filter residues to obtain filtrate, combining the two filtrates, and concentrating to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition is effectively combined and mutually supported according to a main and secondary compatibility relationship of monarch, minister, assistant and guide, is scientifically prepared, has the effects of promoting diuresis, relieving pain, invigorating spleen and replenishing qi, has a remarkable effect on treating spleen-deficiency damp-heat type ulcerative colitis, is good in long-term curative effect, is not easy to relapse, is easily accepted by patients, and is free of toxic and side effects. The traditional Chinese medicine composition is an innovation of medicines for treating spleen deficiency and damp-heat type ulcerative colitis, and has practical popularization and application values.

Description

Technical Field

[0001] This invention relates to the field of medicine, and in particular to a traditional Chinese medicine composition for treating ulcerative colitis of the spleen deficiency and damp-heat type. Background Technology

[0002] Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), clinically characterized by diarrhea, abdominal pain, bloody and purulent stools, and tenesmus. The lesions are primarily concentrated in the colon and rectum, characterized by continuous and diffuse inflammation of the mucosa and submucosa. The pathogenesis of UC is currently unclear, but factors including immune factors, genetics, infection, environment, gut microbiota dysbiosis, diet, and psychological factors are considered. These factors directly contribute to the persistent occurrence, development, and outcome of intestinal inflammation in UC. Epidemiological studies have found that UC is more common in developed countries in North America and Europe, with an incidence rate of 10-20 per 100,000. In my country, the incidence is approximately 11.6 per 100,000, with a higher rate in men than women. In recent years, influenced by the deterioration of the social environment, changes in dietary structure, and lifestyle habits, the overall incidence of UC has shown an upward trend. Because of its chronic and recurrent nature, as well as its certain chance of becoming cancerous, ulcerative colitis (UC) not only seriously affects the treatment effect for patients but also significantly reduces their quality of life. Therefore, it is currently recognized as one of the most difficult-to-treat diseases in the world.

[0003] Traditional Chinese medicine lacks a clear name for ulcerative colitis (UC). Clinically, UC is often categorized under "diarrhea," "intestinal disorders," or "chronic dysentery" based on its characteristic symptoms. The etiology, pathogenesis, and treatment of UC vary among different schools of thought throughout history. Based on long-term clinical practice, the inventors believe that this disease is generally a mixture of deficiency and excess, with the root cause being deficiency and the manifestation being excess. Therefore, they proposed the general principle of the TCM "staged sequential theory," which involves differentiating syndromes and treating according to the stages of UC recurrence, selecting appropriate prescriptions for continuous treatment. Furthermore, based on the evolution of UC's pathogenesis, it is divided into three typical stages: the initial stage of damp-heat accumulation in the large intestine; the middle stage of spleen deficiency with damp-heat; and the final stage of spleen and kidney deficiency. In the initial stage of damp-heat accumulation in the large intestine, the method of "clearing damp-heat in the intestines, supplemented by promoting blood circulation and removing blood stasis" is used to induce remission. For the stage of spleen deficiency with damp-heat, the method of clearing the intestines and strengthening the spleen should continue. For the stage of spleen and kidney deficiency, the method of strengthening the spleen and tonifying the kidney is mainly used. Long-term clinical studies have found that this TCM treatment plan can significantly improve patients' clinical symptoms, promote the repair of the intestinal mucosa and the recovery of immune function. It can also significantly improve patients' quality of life and reduce the recurrence rate of ulcerative colitis (UC).

[0004] Spleen and stomach weakness is a crucial underlying cause of ulcerative colitis (UC) of the spleen deficiency and damp-heat type. When the spleen and stomach are deficient, the balance of qi, blood, yin, and yang is disrupted, the defensive qi is insufficient, and the body's defenses are weakened, making it susceptible to external pathogens. Therefore, symptoms such as fatigue, poor appetite, and borborygmus are commonly observed at this stage. Treatment based on syndrome differentiation focuses on strengthening the spleen and replenishing qi, harmonizing the various organs, and tonifying and regulating the spleen to restore its ascending and descending functions.

[0005] Residual damp-heat is an important factor in the pathogenesis of ulcerative colitis (UC) of the spleen deficiency and damp-heat type. When UC enters the spleen deficiency and damp-heat stage, on the one hand, the damp-heat is about to be eliminated, so symptoms such as abdominal pain, tenesmus, and mucus and bloody stools improve significantly; on the other hand, because the damp-heat is sticky and stagnant, it binds together and obstructs qi and blood, making it difficult to remove easily, resulting in a lingering and difficult-to-cure disease that is very prone to relapse.

[0006] In summary, spleen and stomach weakness, coupled with residual damp-heat, leading to spleen deficiency and damp-heat, is the underlying pathogenesis of ulcerative colitis (UC). Based on this TCM theory, traditional Chinese medicine (TCM) possesses unique advantages in treating intractable diseases. Therefore, the question remains: could a TCM combination be developed to effectively address the medication issues in treating UC? However, no publicly reported studies have yet been published on this topic. Summary of the Invention

[0007] In view of the above situation and to overcome the shortcomings of the existing technology, the purpose of this invention is to provide a traditional Chinese medicine composition for spleen deficiency and damp-heat type ulcerative colitis, which can effectively solve the medication problem of spleen deficiency and damp-heat type ulcerative colitis.

[0008] The technical solution of this invention is a traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, made from the following raw materials by weight: Atractylodes macrocephala 10-15g, Paeonia lactiflora 10-20g, Poria cocos 10-20g, Alisma plantago-aquatica 10-20g, Coptis chinensis 6-8g, Scutellaria baicalensis 10-12g, Euphorbia humifusa 10-15g, Prunus mume 6-8g, Magnolia officinalis 8-10g, and Glycyrrhiza uralensis 6-8g. The above raw materials are then mixed with water. Soak 400-600ml of water at 18-25℃ for 15-25 minutes, then bring to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter to obtain the filtrate and set aside. Add 300-400ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 10-15 minutes. Filter, discard the residue, and obtain the filtrate. Combine the two filtrates and concentrate to 1 / 2-1 / 3 of the total amount of water added to obtain the finished decoction.

[0009] The traditional Chinese medicine composition of this invention can also be prepared into medically acceptable dosage forms, such as decoctions, pills, powders, and capsules, according to the dosage form requirements and conventional dosage form methods. The core of this invention lies in the traditional Chinese medicine composition.

[0010] The formulation of this invention is based on the principle of principal, assistant, adjuvant, and guide drugs, which are combined in an effective and mutually supportive manner. Through scientific preparation, it has the effects of promoting diuresis and relieving pain, strengthening the spleen and replenishing qi. It has a significant effect on treating ulcerative colitis of spleen deficiency and damp-heat type, with good long-term efficacy, low recurrence rate, and easy acceptance by patients. It is an innovation in the treatment of ulcerative colitis of spleen deficiency and damp-heat type and has practical application value. Detailed Implementation

[0011] The specific implementation of the present invention will be described in detail below with reference to examples and specific circumstances.

[0012] The present invention can be described by the following embodiments: Example

[0013] A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type is made from the following raw materials by weight: Atractylodes macrocephala 13g, Paeonia lactiflora 15g, Poria cocos 15g, Alisma plantago-aquatica 15g, Coptis chinensis 7g, Scutellaria baicalensis 11g, Euphorbia humifusa 12g, Prunus mume 7g, Magnolia officinalis 9g, and Glycyrrhiza uralensis 7g. The above raw materials are added to 500ml of water and soaked at 22℃ for 20 minutes. Then, the mixture is brought to a boil over high heat, then simmered over low heat for 25 minutes. The mixture is filtered to obtain the filtrate, which is set aside. The residue is added to 350ml of water, brought to a boil over high heat, then simmered over low heat for 12 minutes. The residue is filtered, and the filtrate is discarded. The two filtrates are combined and concentrated to 360ml to obtain the finished decoction. Example

[0014] A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type is made from the following raw materials by weight: 15g of Atractylodes macrocephala, 20g of Paeonia lactiflora, 20g of Poria cocos, 20g of Alisma plantago-aquatica, 8g of Coptis chinensis, 12g of Scutellaria baicalensis, 15g of Euphorbia humifusa, 8g of Prunus mume, 10g of Magnolia officinalis, and 8g of Glycyrrhiza uralensis. The above raw materials are added to 600ml of water and soaked at 25℃ for 25 minutes. Then, the mixture is brought to a boil over high heat, then simmered over low heat for 30 minutes. The mixture is filtered to obtain the filtrate, which is set aside. The residue is added to 400ml of water, brought to a boil over high heat, then simmered over low heat for 15 minutes. The mixture is filtered, the residue is discarded, and the filtrate is obtained. The two filtrates are combined and concentrated to 500ml to obtain the finished decoction. Example

[0015] A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type is made from the following raw materials by weight: 10g of Atractylodes macrocephala, 10g of Paeonia lactiflora, 10g of Poria cocos, 10g of Alisma plantago-aquatica, 6g of Coptis chinensis, 10g of Scutellaria baicalensis, 10g of Euphorbia humifusa, 6g of Prunus mume, 8g of Magnolia officinalis, and 6g of Glycyrrhiza uralensis. The above raw materials are added to 400ml of water and soaked at 18℃ for 15 minutes. Then, the mixture is brought to a boil over high heat, then simmered over low heat for 20 minutes. The mixture is filtered to obtain the filtrate, which is set aside. The residue is added to 300ml of water, brought to a boil over high heat, then simmered over low heat for 10 minutes. The residue is filtered, and the filtrate is discarded. The two filtrates are combined and concentrated to 240ml to obtain the finished decoction. Example

[0016] A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type is made from the following raw materials by weight: Atractylodes macrocephala 15g, Paeonia lactiflora 10g, Poria cocos 20g, Alisma plantago-aquatica 10g, Coptis chinensis 8g, Scutellaria baicalensis 10g, Euphorbia humifusa 15g, Prunus mume 6g, Magnolia officinalis 10g, and Glycyrrhiza uralensis 6g. The above raw materials are added to 600ml of water and soaked at 25℃ for 25 minutes. Then, the mixture is brought to a boil over high heat, then simmered over low heat for 30 minutes. The mixture is filtered to obtain the filtrate, which is set aside. The residue is added to 300ml of water, brought to a boil over high heat, then simmered over low heat for 10 minutes. The residue is filtered, and the filtrate is discarded. The two filtrates are combined and concentrated to 400ml to obtain the finished decoction. Example

[0017] A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type is made from the following raw materials by weight: 10g of Atractylodes macrocephala, 20g of Paeonia lactiflora, 10g of Poria cocos, 20g of Alisma plantago-aquatica, 6g of Coptis chinensis, 12g of Scutellaria baicalensis, 10g of Euphorbia humifusa, 8g of Prunus mume, 8g of Magnolia officinalis, and 8g of Glycyrrhiza uralensis. The above raw materials are added to 400ml of water and soaked at 18℃ for 15 minutes. Then, the mixture is brought to a boil over high heat, then simmered over low heat for 20 minutes. The mixture is filtered to obtain the filtrate, which is set aside. The residue is added to 400ml of water, brought to a boil over high heat, then simmered over low heat for 15 minutes. The mixture is filtered, the residue is discarded, and the filtrate is obtained. The two filtrates are combined and concentrated to 320ml to obtain the finished decoction.

[0018] The compositions given in the above embodiments can be used to prepare any amount of traditional Chinese medicine as needed. The given embodiments are only used to illustrate specific implementation methods of the present invention, and are not intended to limit the scope of protection of the present invention. The core and key technology protected by the present invention is the compatibility of traditional Chinese medicine compositions.

[0019] The traditional Chinese medicine composition of this invention can be formulated into any medically acceptable dosage form, such as decoction, powder, pill, capsule or oral liquid, according to the needs of administration.

[0020] Among the above components, which are: Atractylodes macrocephala: bitter, sweet, warm; enters the spleen and stomach meridians; strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and calms the fetus; White peony root; bitter, sour, slightly cold; enters the liver and spleen meridians; soothes the liver and relieves pain, nourishes blood and regulates menstruation, astringes yin and stops sweating; White Poria; sweet, bland, neutral; enters the heart, spleen, lung, and kidney meridians; promotes diuresis and eliminates dampness, strengthens the spleen and stomach, calms the mind and soothes the nerves; Alisma plantago-aquatica; sweet and bland, cold; enters the kidney and bladder meridians; promotes diuresis and eliminates dampness, clears damp-heat; Coptis chinensis; bitter, cold; enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians; clears heat and dries dampness, drains fire and detoxifies; Scutellaria baicalensis; bitter, cold; enters the lung, gallbladder, spleen, large intestine, and small intestine meridians; clears heat and dries dampness, drains fire and detoxifies, stops bleeding, and calms the fetus; Euphorbia humifusa; tastes bitter, pungent, and neutral; enters the liver, stomach, and large intestine meridians; clears heat and detoxifies, cools the blood and stops bleeding, promotes diuresis, and promotes lactation; Ume plum; sour, astringent, neutral; enters the liver, spleen, lung, and large intestine meridians; astringes the lungs, astringes the intestines, promotes the production of body fluids, and expels roundworms; Magnolia officinalis; bitter, pungent, warm; enters the spleen, stomach, lung, and large intestine meridians; promotes qi circulation, dries dampness, eliminates stagnation, and relieves asthma; Licorice; sweet, neutral; enters the heart, lung, spleen, and stomach meridians; tonifies the spleen and replenishes qi, clears heat and detoxifies, eliminates phlegm and relieves cough, alleviates spasms and pain, and harmonizes other herbs.

[0021] The formula contains Atractylodes macrocephala, Paeonia lactiflora, and Poria cocos, also known as "Sanbai San" (Three White Powder), which invigorate the spleen and promote diuresis, and are effective for treating spleen deficiency edema, abdominal distension, and loose stools. These three herbs are the principal herbs. Alisma plantago-aquatica, Coptis chinensis, Scutellaria baicalensis, and Euphorbia humifusa clear heat, promote diuresis, and stop dysentery, serving as the assistant herbs. Prunus mume is effective in treating diarrhea with mixed cold and heat patterns, while Magnolia officinalis promotes qi circulation and relieves bloating, serving as the adjuvant herbs. Glycyrrhiza uralensis harmonizes the other herbs, serving as the guiding herb. This effective combination of herbs, mutually supporting each other, and through scientific preparation, possesses the functions of promoting diuresis, relieving pain, invigorating the spleen, and replenishing qi. Experiments have yielded very good and beneficial technical results, and the relevant experimental data are as follows (taking Example 1 as an example):

[0022] Sixty patients with mild to moderate chronic relapsing ulcerative colitis (UC) with active phase (spleen deficiency and damp-heat type) who visited the Department of Gastroenterology of our hospital from January 2024 to January 2025 were selected as the study subjects.

[0023] Referencing the "Guidelines for the Diagnosis and Treatment of Ulcerative Colitis in China" formulated in Xi'an in 2023. 1) Clinical manifestations: ① During the active phase of the disease, the main symptoms are abdominal pain, diarrhea, mucus and bloody stools, and tenesmus. Symptoms often recur, and the course of the disease is usually longer than 4-6 weeks. ② When the condition is severe or the onset is acute, it may be accompanied by varying degrees of systemic symptoms. ③ Extraintestinal manifestations often occur in the skin, joints, eyes, and other parts of the body. 2) Colonoscopy: ① Intestinal mucosal damage is often continuous and retrograde, progressing proximally; the lesion originates in the rectum; ② Endoscopic findings show varying degrees of mucosal damage, manifested as erythema, congestion, edema, erosion, spontaneous bleeding or contact bleeding; mucosal vascular patterns are blurred or even disappear; the mucosal surface is rough and granular; ③ The colonic haustra may appear shallower, blunter, or disappear, and pseudopolyps may form; 3) Histological examination of mucosa: The main pathological manifestations in the active phase are: ① a large number of acute and chronic inflammatory cells infiltrate the lamina propria, with cryptitis and crypt abscesses; ② changes in crypt structure, irregular shape and size, disordered arrangement, and a decrease in goblet cells; ③ erosion, shallow ulceration and granulation tissue can be seen on the mucosal surface. A diagnosis of the disease requires meeting all three of the above diagnostic criteria and excluding other types of intestinal diseases.

[0024] Traditional Chinese Medicine Diagnostic Criteria Formulated with reference to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine Drugs" and the "Expert Consensus on the Diagnosis and Treatment of Ulcerative Colitis with Traditional Chinese Medicine" Spleen deficiency with damp-heat type: Main symptoms: Incomplete or urgent bowel movements, or stools containing mucus, pus, or blood, abdominal pain, diarrhea, and fatigue. Secondary symptoms: abdominal pain and distension, poor appetite, and burning sensation in the anus; Tongue and pulse: The tongue is pale red or has teeth marks on the edges, the coating is white and greasy or yellow and greasy, and the pulse is soft and rapid; Syndrome diagnosis: Two primary symptoms and two secondary symptoms, or one primary symptom plus three secondary symptoms, with reference to tongue and pulse manifestations for diagnosis.

[0025] 1) Meets the Western medical diagnostic criteria for UC; 2) Patients with mild to moderate UC in the active phase (Mayo score between 3 and 11); 3) According to traditional Chinese medicine syndrome differentiation, it belongs to the spleen deficiency and damp-heat syndrome; 4) Individuals aged 18-75 (inclusive) who voluntarily sign the informed consent form can be included in the trial.

[0026] 1) Individuals under 18 years of age or over 75 years of age, pregnant or planning to become pregnant, breastfeeding women, and those who are intolerant to the investigational drug; 2) Patients with serious heart, brain, liver, kidney, or hematopoietic system diseases who require drug treatment; 3) Patients with serious complications, such as local stenosis, intestinal obstruction, intestinal perforation, toxic megacolon, lower gastrointestinal bleeding, intestinal cancer, and anal diseases; 4) Individuals suffering from severe mental illnesses such as schizophrenia, anxiety, or depression, or those with intellectual disabilities who are unable to cooperate; 5) Individuals allergic to the drugs used in this experiment; 6) Currently participating in other research projects.

[0027] The 60 selected subjects were randomly assigned to a treatment group and a control group, with 30 patients in each group.

[0028] Treatment duration: 4 weeks Control group: Mesalazine enteric-coated tablets (250mg × 24 tablets, National Drug Approval Number H19980148, Sunflower Pharmaceutical Group Jiamusi Luling Pharmaceutical Co., Ltd.), 4g / day, taken orally in divided doses of 1g / time, three times a day and before bedtime; Treatment group: Mesalazine enteric-coated tablets (specific usage as in the control group) combined with the traditional Chinese medicine decoction prepared in this invention, 200ml each time, once in the morning and once in the evening.

[0029] The TCM clinical syndrome scoring table was developed with reference to the "Guiding Principles for Clinical Research of New Chinese Medicines (2002 Edition)," and the specific indicators are shown in Table 1.

[0030] Table 1. Traditional Chinese Medicine Clinical Symptom Score Table

[0031] Note: Major TCM clinical symptoms include frequent bowel movements, mucus and bloody stools, abdominal pain, and fatigue. Minor TCM clinical symptoms include tenesmus, borborygmus, poor appetite, and anal burning. Each symptom can be categorized as normal, mild, moderate, or severe. Major TCM clinical symptoms are scored as 0, 3, 6, and 9 points respectively, while minor TCM clinical symptoms are scored as 0, 1, 2, and 3 points respectively.

[0032] Based on the above clinical symptom scoring criteria, the reduction in symptom score is used as the criterion for determining therapeutic efficacy: Ineffective: The reduction in symptom score is less than 20%; Effective: The number of symptoms decreased by ≥20% and <50%; Significant effect: The number of symptoms is reduced by ≥50% and <85%.

[0033] According to the above efficacy evaluation criteria, after statistical processing, in the treatment group, 2 cases were ineffective, 8 cases were effective, and 20 cases showed significant improvement, with a total effective rate of 93.3%; in the control group, 5 cases were ineffective, 13 cases were effective, and 12 cases showed significant improvement, with a total effective rate of 83.3%. Further testing revealed… P <0.05, the treatment group showed significantly better efficacy than the control group, as shown in Table 2: Table 2. Evaluation of Clinical Efficacy [n(%)] Grouping Number of examples invalid efficient Effective Overall efficiency Treatment group 30 people 2 people (6.7%) 8 people (26.6%) 20 people (66.7%) 93.3% control group 30 people 5 people (16.7%) 13 people (43.3%) 12 people (40.0%) 83.3%

[0034] No drug-related adverse events occurred in either group of subjects during the treatment. Laboratory monitoring data showed that liver and kidney function indicators (ALT, AST, blood urea nitrogen, serum creatinine) and electrocardiogram parameters did not show significant abnormal fluctuations before and after the intervention, indicating that the treatment regimen has reliable safety characteristics.

[0035] As can be seen from the above, the raw materials of this invention are abundant, the preparation method is simple, easy to take, low in cost, and effective. The components are matched according to the principal-assistant-adjuvant relationship, supporting each other and having the effects of promoting diuresis and relieving pain, strengthening the spleen and replenishing qi. The whole formula works together, not only with stable efficacy but also with good long-term efficacy, with a total effective rate of up to 93.3%. It is not easy to relapse and is easily accepted by patients. It is effective in treating ulcerative colitis of spleen deficiency and damp-heat type. The traditional Chinese medicine composition of this invention, characterized by simplicity, convenience, low cost and effectiveness, conforms to the pathogenesis of ulcerative colitis and is an innovation in the treatment of ulcerative colitis drugs, with practical application value.

Claims

1. A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, characterized in that, The decoction is prepared from the following raw materials by weight: Atractylodes macrocephala 10-15g, Paeonia lactiflora 10-20g, Poria cocos 10-20g, Alisma plantago-aquatica 10-20g, Coptis chinensis 6-8g, Scutellaria baicalensis 10-12g, Euphorbia humifusa 10-15g, Prunus mume 6-8g, Magnolia officinalis 8-10g, and Glycyrrhiza uralensis 6-8g. Add 400-600ml of water to the above raw materials and soak at 18-25℃ for 15-25 minutes. Then bring to a boil over high heat, then simmer over low heat for 20-30 minutes. Filter to obtain the filtrate, which is set aside. Add 300-400ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 10-15 minutes. Filter, discard the residue, and obtain the filtrate. Combine the two filtrates and concentrate to 1 / 2-1 / 3 of the total amount of water added to obtain the finished decoction.

2. A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, characterized in that, The decoction is prepared from the following raw materials by weight: Atractylodes macrocephala 13g, Paeonia lactiflora 15g, Poria cocos 15g, Alisma plantago-aquatica 15g, Coptis chinensis 7g, Scutellaria baicalensis 11g, Euphorbia humifusa 12g, Prunus mume 7g, Magnolia officinalis 9g, and Glycyrrhiza uralensis 7g. Add 500ml of water to the above raw materials and soak at 22℃ for 20 minutes. Then bring to a boil over high heat, then simmer over low heat for 25 minutes. Filter to obtain the filtrate, which is set aside. Add 350ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 12 minutes. Filter, discard the residue, and obtain the filtrate. Combine the two filtrates and concentrate to 360ml to obtain the finished decoction.

3. A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, characterized in that, The decoction is prepared from the following raw materials by weight: 15g of Atractylodes macrocephala, 20g of Paeonia lactiflora, 20g of Poria cocos, 20g of Alisma plantago-aquatica, 8g of Coptis chinensis, 12g of Scutellaria baicalensis, 15g of Euphorbia humifusa, 8g of Prunus mume, 10g of Magnolia officinalis, and 8g of Glycyrrhiza uralensis. Add 600ml of water to the above raw materials and soak at 25℃ for 25 minutes. Then bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the filtrate, which is set aside. Add 400ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 15 minutes. Filter, discard the residue, and obtain the filtrate. Combine the two filtrates and concentrate to 500ml to obtain the finished decoction.

4. A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, characterized in that, The decoction is prepared from the following raw materials by weight: 10g of Atractylodes macrocephala, 10g of Paeonia lactiflora, 10g of Poria cocos, 10g of Alisma plantago-aquatica, 6g of Coptis chinensis, 10g of Scutellaria baicalensis, 10g of Euphorbia humifusa, 6g of Prunus mume, 8g of Magnolia officinalis, and 6g of Glycyrrhiza uralensis. Add 400ml of water to the above raw materials and soak at 18℃ for 15 minutes. Then bring to a boil over high heat, then simmer over low heat for 20 minutes. Filter to obtain the filtrate, which is set aside. Add 300ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 10 minutes. Filter and discard the residue to obtain the filtrate. Combine the two filtrates and concentrate to 240ml to obtain the finished decoction.

5. A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, characterized in that, The decoction is prepared from the following ingredients by weight: 15g of Atractylodes macrocephala, 10g of Paeonia lactiflora, 20g of Poria cocos, 10g of Alisma plantago-aquatica, 8g of Coptis chinensis, 10g of Scutellaria baicalensis, 15g of Euphorbia humifusa, 6g of Prunus mume, 10g of Magnolia officinalis, and 6g of Glycyrrhiza uralensis. Add 600ml of water to the above ingredients and soak at 25℃ for 25 minutes. Then bring to a boil over high heat, then simmer over low heat for 30 minutes. Filter to obtain the filtrate, which is set aside. Add 300ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 10 minutes. Filter and discard the residue to obtain the filtrate. Combine the two filtrates and concentrate to 400ml to obtain the finished decoction.

6. A traditional Chinese medicine composition for ulcerative colitis of spleen deficiency and damp-heat type, characterized in that, The decoction is prepared from the following raw materials by weight: 10g of Atractylodes macrocephala, 20g of Paeonia lactiflora, 10g of Poria cocos, 20g of Alisma plantago-aquatica, 6g of Coptis chinensis, 12g of Scutellaria baicalensis, 10g of Euphorbia humifusa, 8g of Prunus mume, 8g of Magnolia officinalis, and 8g of Glycyrrhiza uralensis. Add 400ml of water to the above raw materials and soak at 18℃ for 15 minutes. Then bring to a boil over high heat, then simmer over low heat for 20 minutes. Filter to obtain the filtrate, which is set aside. Add 400ml of water to the residue, bring to a boil over high heat, then simmer over low heat for 15 minutes. Filter and discard the residue to obtain the filtrate. Combine the two filtrates and concentrate to 320ml to obtain the finished decoction.

7. The traditional Chinese medicine composition according to any one of claims 1-6, the traditional Chinese medicine composition of the present invention can also be formulated into a medically acceptable dosage form according to the dosage form requirements.

8. The traditional Chinese medicine composition according to claim 7, characterized in that, The dosage forms mentioned are decoctions, pills, powders, and capsules.

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