Traditional Chinese medicine composition capable of invigorating spleen, eliminating dampness and reducing weight as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition for invigorating spleen, eliminating dampness and reducing weight as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition for invigorating spleen, eliminating dampness and reducing weight comprises the following components in parts by weight: 20-40 parts of white hyacinth bean, 15-25 parts of rabdosia lingua, 10-15 parts of bighead atractylodes rhizome, 5-10 parts of Chinese yam and 3-7 parts of xanthoceras sorbifolia bunge. According to the traditional Chinese medicine composition, the white hyacinth bean is used as a monarch drug, the rabdosia lophanthoides is matched as a ministerial drug, the rhizoma atractylodis macrocephalae and the Chinese yam are used as adjuvant drugs, the xanthoceras sorbifolia bunge is used as a conductant drug, and all the drugs are combined, so that the problem of endogenous pathogenic dampness caused by dysfunction of the spleen and the stomach can be effectively solved, the purpose of invigorating the spleen to eliminate dampness is achieved, and an excellent effect is shown in the aspect of weight loss; a safe and effective novel treatment means based on the traditional Chinese medicine theory is provided for obese people, and wide clinical application prospects are achieved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, as well as its preparation method and application. Background Technology

[0002] With socioeconomic development and changes in lifestyle, the number of obese people worldwide is rising sharply. According to statistics from the World Health Organization (WHO), obesity has become a serious global public health problem. In my country, the incidence of obesity is also increasing year by year, especially in large cities and economically developed areas, where the problem is more prominent.

[0003] Obesity not only affects an individual's appearance, but more importantly, it is closely related to the development of various chronic diseases. Studies have shown that obesity is a significant risk factor for type 2 diabetes, cardiovascular diseases (such as coronary heart disease and hypertension), certain cancers (such as breast cancer and colorectal cancer), and bone and joint diseases. These diseases not only seriously threaten patients' physical health and quality of life, but also impose a heavy economic burden on families and society. Therefore, finding safe and effective weight loss methods is of great practical significance. Summary of the Invention

[0004] To address the above problems, this invention provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, as well as its preparation method and application.

[0005] In a first aspect, the present invention provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, wherein the traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight comprises the following components in parts by weight: White hyacinth bean 20-40 parts, narrow-ribbed fragrant tea 15-25 parts, Atractylodes macrocephala 10-15 parts, Dioscorea opposita 5-10 parts and Sapindus mukorossi 3-7 parts.

[0006] Furthermore, the weight ratio of the white hyacinth bean to the narrow-ribbed fragrant tea vegetable is 1.5:1.

[0007] Furthermore, by weight, the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition comprises the following components: White hyacinth bean 25-35 parts, narrow-ribbed fragrant tea 18-22 parts, Atractylodes macrocephala 12-14 parts, Dioscorea opposita 7-9 parts and Sapindus mukorossi 4-6 parts.

[0008] Furthermore, by weight, the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition comprises the following components: 30 portions of white hyacinth bean, 20 portions of narrow-ribbed fragrant tea leaf, 13 portions of Atractylodes macrocephala, 8 portions of yam, and 5 portions of Sapindus mukorossi.

[0009] Secondly, the present invention provides a method for preparing the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to any one of the first aspects, wherein the method for preparing the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition includes the following steps: White hyacinth bean, narrow-lined fragrant tea leaf, Atractylodes macrocephala, yam and Sapindus mukorossi are mixed and crushed to obtain a mixture; The mixture was added to water and extracted under reduced pressure by reflux. The resulting extract was then concentrated and dried to obtain the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition.

[0010] Furthermore, the working conditions for the reduced pressure reflux extraction include: temperature of 15~25℃, pressure of 9~15KPa, time of 60~90min, and number of extractions of 1~3.

[0011] Furthermore, the temperature of the vacuum reflux extraction is 20°C.

[0012] Furthermore, the pressure of the depressurization reflux extraction is 12 kPa.

[0013] Thirdly, the present invention provides the application of the spleen-strengthening and dampness-resolving weight-reducing traditional Chinese medicine composition as described in any one of the first aspects, or the spleen-strengthening and dampness-resolving weight-reducing traditional Chinese medicine composition prepared by the preparation method of the spleen-strengthening and dampness-resolving weight-reducing traditional Chinese medicine composition as described in any one of the second aspects, in the preparation of weight-reducing drugs and weight-reducing health products.

[0014] Furthermore, both the weight loss drug and the weight loss health product are available in granule and liquid forms.

[0015] The technical solutions provided in the embodiments of the present invention have at least the following advantages compared with the prior art: This invention provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, along with its preparation method and application. The composition uses white hyacinth bean as the principal ingredient, combined with narrow-spotted fragrant tea leaves as the assistant ingredient, atractylodes macrocephala and yam as adjuvant ingredients, and *Xanthoceras sorbifolium* as the guiding ingredient. White hyacinth bean, the principal ingredient, strengthens the spleen and resolves dampness; fragrant tea leaves, the assistant ingredient, enhance diuresis and liver protection; atractylodes macrocephala and yam, the adjuvant ingredients, consolidate spleen and stomach function and regulate metabolism; and *Xanthoceras sorbifolium*, the guiding ingredient, guides the efficacy and enhances antioxidant and anti-inflammatory capabilities. The combined use of these herbs, through a progressive pathway of "strengthening the spleen → resolving dampness → reducing weight," achieves multi-target effects, from improving spleen and stomach function to regulating lipid metabolism, inhibiting fat absorption, and providing anti-inflammatory and antioxidant effects. This not only effectively improves the problem of internal dampness caused by spleen and stomach dysfunction, achieving the goal of strengthening the spleen and resolving dampness, but also demonstrates excellent weight loss effects. It provides a safe, effective, and novel treatment method based on traditional Chinese medicine theory for obese individuals, with broad clinical application prospects. Detailed Implementation

[0016] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0017] Unless otherwise specified, all raw materials, reagents, instruments, and equipment used in this invention can be purchased from the market or prepared using existing methods. Furthermore, unless otherwise specified or detailed, the steps and parameters involved can be performed according to existing traditional Chinese medicine processing techniques or directly using existing equipment; these will not be elaborated upon in this invention document.

[0018] The present invention will be further illustrated below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Experimental methods in the following embodiments, unless otherwise specified, are generally performed according to national standards. If no corresponding national standard exists, then generally accepted international standards, conventional conditions, or conditions recommended by the manufacturer are followed.

[0019] Example 1

[0020] This example provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight. By weight, the composition comprises the following components: 30 portions of white hyacinth bean, 20 portions of narrow-ribbed fragrant tea leaf, 13 portions of Atractylodes macrocephala, 8 portions of yam, and 5 portions of Sapindus mukorossi.

[0021] The preparation method of the above-mentioned spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition includes the following steps: White hyacinth bean, narrow-lined fragrant tea leaf, Atractylodes macrocephala, yam and Sapindus mukorossi are mixed and crushed to obtain a mixture; The mixture was added to water and subjected to vacuum reflux extraction twice. The vacuum reflux extraction temperature was 20℃, the vacuum reflux extraction pressure was 12KPa, and the vacuum reflux extraction time was 75min. The resulting extract was then concentrated and dried to obtain the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition.

[0022] Example 2

[0023] This example provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight. By weight, the composition comprises the following components: 20 portions of white hyacinth bean, 15 portions of narrow-ribbed fragrant tea leaf, 10 portions of Atractylodes macrocephala, 5 portions of Dioscorea opposita, and 3 portions of Xanthoceras sorbifolium.

[0024] The preparation method of the above-mentioned spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition includes the following steps: White hyacinth bean, narrow-lined fragrant tea leaf, Atractylodes macrocephala, yam and Sapindus mukorossi are mixed and crushed to obtain a mixture; The mixture was added to water and subjected to vacuum reflux extraction twice. The vacuum reflux extraction temperature was 15℃, the vacuum reflux extraction pressure was 9KPa, and the vacuum reflux extraction time was 90min. The resulting extract was then concentrated and dried to obtain the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition.

[0025] Example 3

[0026] This example provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight. By weight, the composition comprises the following components: 40 portions of white hyacinth bean, 25 portions of narrow-ribbed fragrant tea, 15 portions of Atractylodes macrocephala, 10 portions of Dioscorea opposita and 7 portions of Xanthoceras sorbifolium.

[0027] The preparation method of the above-mentioned spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition includes the following steps: White hyacinth bean, narrow-lined fragrant tea leaf, Atractylodes macrocephala, yam and Sapindus mukorossi are mixed and crushed to obtain a mixture; The mixture was added to water and subjected to vacuum reflux extraction twice. The vacuum reflux extraction temperature was 25℃, the vacuum reflux extraction pressure was 15KPa, and the vacuum reflux extraction time was 60min. The resulting extract was then concentrated and dried to obtain the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition.

[0028] Comparative Example 1 This example provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, and its preparation method. The only difference from Example 1 is that the narrow-skinned fragrant tea leaves are not added; all other steps and parameters are the same.

[0029] Comparative Example 2 This example provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, and its preparation method. The only difference from Example 1 is that the reduced pressure reflux extraction is changed to normal pressure reflux extraction, that is, the temperature is adjusted to 105℃ and the pressure is adjusted to normal pressure; the remaining steps and parameters are the same.

[0030] Comparative Example 3 This example provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, and its preparation method. The only difference from Example 1 is that the white hyacinth bean is adjusted to 20 parts and the narrow-spotted fragrant tea leaf is adjusted to 30 parts; the remaining steps and parameters are the same.

[0031] Test case This example tests the weight loss efficacy of the traditional Chinese medicine compositions obtained in Examples 1-3 and Comparative Examples 1-3.

[0032] The testing method is as follows: 1. Experimental animals: SPF grade C57 male mice, weighing 17.2±0.3g.

[0033] 2. Model Establishment: Four-week-old C57 mice were divided into two groups after 5 days of acclimatization feeding. One group (n=10) served as the control group, fed with standard feed; the other group (n=0) served as the model group, fed with a high-fat feed. Mice had free access to food and water during the feeding period. Mouse weight and food intake were measured every two days. After 5 weeks of feeding, a significant difference in weight gain between the model group and the control group was considered a successful model establishment. No significant change in food intake was observed between the model group and the control group.

[0034] 3. Drug administration test: Mice that successfully established the model were randomly divided into 7 groups, with 10 mice in each group. Among them, group 1 was the high-fat model control group, which was fed with a high-fat diet; the other 6 groups were drug administration test groups 1-6 (drug administration test group 1 was given the traditional Chinese medicine composition provided in Example 1, drug administration test group 2 was given the traditional Chinese medicine composition provided in Example 2, drug administration test group 3 was given the traditional Chinese medicine composition provided in Example 3, drug administration test group 4 was given the traditional Chinese medicine composition provided in Comparative Example 1, drug administration test group 5 was given the traditional Chinese medicine composition provided in Comparative Example 2, and drug administration test group 6 was given the traditional Chinese medicine composition provided in Comparative Example 3). In addition to being fed with a high-fat diet, the mice were also administered the traditional Chinese medicine compositions of Examples 1-3 and Comparative Example 13 by gavage at 10:00 am every day. Before gavage, the traditional Chinese medicine weight loss composition was dissolved in distilled water to form a suspension. The gavage dose was 0.4 g / kg / day. The high-fat model control group was administered the same volume of distilled water by gavage.

[0035] The body weight of the mice was tested at 0 weeks and 7 weeks, and the results are shown in Table 1.

[0036] Table 1 Test group Weight (0 weeks, g) Weight (7 weeks, g) High-fat model control group 28.12±1.05 34.19±1.67 Drug administration test group 1 28.03±1.21 29.85±1.40 Drug administration test group 2 28.16±1.14 30.44±1.28 Drug administration test group 3 28.15±1.09 29.97±1.36 Drug administration test group 4 28.08±1.26 33.01±1.35 Drug administration test group 5 28.01±1.18 32.46±1.23 Drug administration test group 6 28.14±1.20 32.19±1.21 As shown in Table 1, compared with Comparative Examples 1-3, the traditional Chinese medicine compositions provided in Examples 1-3 of this invention have a better weight loss effect on the high-fat model control group.

[0037] The above description is merely a specific embodiment of the present invention, enabling those skilled in the art to understand or implement the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight, characterized in that, The spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition comprises the following components by weight: White hyacinth bean 20-40 parts, narrow-ribbed fragrant tea 15-25 parts, Atractylodes macrocephala 10-15 parts, Dioscorea opposita 5-10 parts and Sapindus mukorossi 3-7 parts.

2. The spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to claim 1, characterized in that, The weight ratio of the white hyacinth bean to the narrow-ribbed fragrant tea leaf is 1.5:

1.

3. The spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to claim 1, characterized in that, The spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition comprises the following components by weight: White hyacinth bean 25-35 parts, narrow-ribbed fragrant tea 18-22 parts, Atractylodes macrocephala 12-14 parts, Dioscorea opposita 7-9 parts and Sapindus mukorossi 4-6 parts.

4. The spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to claim 1, characterized in that, The spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition comprises the following components by weight: 30 portions of white hyacinth bean, 20 portions of narrow-ribbed fragrant tea leaf, 13 portions of Atractylodes macrocephala, 8 portions of yam, and 5 portions of Sapindus mukorossi.

5. A method for preparing a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, and reducing weight according to any one of claims 1 to 4, characterized in that, The preparation method of the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition includes the following steps: White hyacinth bean, narrow-lined fragrant tea leaf, Atractylodes macrocephala, yam and Sapindus mukorossi are mixed and crushed to obtain a mixture; The mixture was added to water and extracted under reduced pressure by reflux. The resulting extract was then concentrated and dried to obtain the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition.

6. The preparation method of the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to claim 5, characterized in that, The working conditions for the reduced pressure reflux extraction include: temperature of 15~25℃, pressure of 9~15KPa, time of 60~90min, and number of extractions of 1~3.

7. The preparation method of the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to claim 6, characterized in that, The temperature for the vacuum reflux extraction is 20°C.

8. The method for preparing the spleen-strengthening, dampness-resolving, and weight-reducing traditional Chinese medicine composition according to claim 6, characterized in that, The pressure for the depressurization reflux extraction is 12 kPa.

9. The use of a traditional Chinese medicine composition for invigorating the spleen and resolving dampness for weight loss, as described in any one of claims 1 to 4, or a traditional Chinese medicine composition for invigorating the spleen and resolving dampness for weight loss prepared by the method described in any one of claims 5 to 8, in the preparation of weight loss drugs and weight loss health products.

10. The application according to claim 9, characterized in that, The dosage forms of both the weight loss drugs and the weight loss health products include granules and liquids.