Heat-clearing and dryness-moistening composition prepared based on radix polygonati officinalis and mint and preparation method of heat-clearing and dryness-moistening composition

Abstract

The invention discloses a heat-clearing and dryness-moistening composition prepared based on radix polygonati officinalis and mint and a preparation method of the heat-clearing and dryness-moistening composition, and particularly relates to the technical field of compound prescriptions.The heat-clearing and dryness-moistening composition is prepared from, by weight, 50-150 g of licorice roots, 10-40 g of tremella fuciformis, 50-150 g of apricot kernels, 50-150 g of radix polygonati officinalis, 100-200 g of hawthorn fruits, 50-150 g of mint, 50-150 g of platycodon grandiflorum and 100-200 g of exocarpium citri rubrum. , 50-150 g of dandelion, and 50-150 g of dark plum. The heat-clearing and dryness-moistening composition has the effects of clearing heat, moistening dryness, relieving, repairing, cooling and refreshing.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of compound prescription, and particularly relates to a heat-clearing and dryness-moistening composition prepared from polygonatum and mint and a preparation method thereof. BACKGROUND

[0002] In the traditional field of Chinese medicine, heat-clearing and dryness-moistening preparations are widely used to improve symptoms such as dry mouth, sore throat, cough and little sputum caused by autumn dryness damaging body fluid and lung and stomach heat. Although the classic prescription represented by Sangxintang (Dissertation on Warm Diseases) has certain curative effect, the addition amount of sucrose is as high as 30-50%, which is not suitable for people with diabetes and sugar control. And the commercially available solid granules such as Jukuanrunzai Granules also cause more than 40% loss of volatile components such as menthol due to high-temperature spray drying.

[0003] As a core medicinal material for nourishing yin and moistening dryness, polygonatum odoratum is prone to Maillard reaction and browning at a temperature higher than 85 DEG C. The retention rate of menthol in the volatile oil of mint is less than 60% under open boiling conditions. More importantly, the conventional decoction process is difficult to meet the stability requirements of tremella polysaccharide and taraxacum mongolicum lev. For example, in the prior art, single normal pressure concentration method is used, which easily leads to a degradation rate of more than 32% of tremella acidic polysaccharide, and cannot effectively reconcile the stability conflict between organic acid (pH is about 2.9) of Fructus mume and bitter almond glycoside (optimum pH is 6.5) of almond. Moreover, in the prior art, volatile oil is embedded by beta-cyclodextrin, but the additional embedding agent causes a 27% decrease in the hardness of the paste, which affects the texture of the product.

[0004] Therefore, it is urgent to develop a heat-clearing and dryness-moistening composition preparation method which can meet the stability requirements of multiple active ingredients and realize low sugar and high bioavailability. SUMMARY

[0005] The application provides a heat-clearing and dryness-moistening composition prepared from polygonatum and mint and a preparation method thereof.

[0006] The purpose of the application is achieved by the following technical scheme. A heat-clearing and dryness-moistening composition prepared from polygonatum and mint is composed of the following components in a certain amount: Glycyrrhiza 50-150 g, Tremella 10-40 g, Almond 50-150 g, Polygonatum 50-150 g, Crataegus 100-200 g, Mentha 50-150 g, Platycodon 50-150 g, Citrus red 100-200 g, Taraxacum mongolicum lev 50-150 g and Fructus mume 50-150 g.

[0007] As preferred, the heat-clearing and dryness-moistening composition is composed of the following components with the following weight content: licorice 80-120 grams, tremella 15-30 grams, apricot kernel 80-120 grams, polygonatum 80-120 grams, hawthorn 120-160 grams, mint 80-120 grams, platycodon 80-120 grams, orange red 110-140 grams, dandelion 80-120 grams, and dark plum 80-120 grams.

[0008] As preferred, the heat-clearing and dryness-moistening composition is composed of the following components with the following weight content: licorice 80-120 grams, tremella 15-30 grams, apricot kernel 80-120 grams, polygonatum 80-120 grams, hawthorn 120-160 grams, mint 80-120 grams, platycodon 80-120 grams, orange red 110-140 grams, dandelion 80-120 grams, and dark plum 80-120 grams.

[0009] As preferred, the heat-clearing and dryness-moistening composition further comprises maltose 100-150 grams.

[0010] As preferred, the heat-clearing and dryness-moistening composition is a paste.

[0011] The application further provides a preparation method of the heat-clearing and dryness-moistening composition prepared based on polygonatum and mint, which comprises the following steps: S01, pretreatment stage Pretreatment of tremella: the tremella is soaked in cold water alone for 1-2 hours until fully swelled, the hard root is cut off, and the tremella is torn into small pieces for standby; Soaking of hard medicinal materials: the polygonatum, platycodon, orange red, apricot kernel, and dark plum are soaked in warm water for 20-30 minutes to soften the fiber tissues; Post-treatment of volatile substances: the mint is stored alone in a sealed manner to avoid loss of fragrance; S02, decoction process flow First decoction: all the medicinal materials except the tremella and the mint are poured into 8-10 L of clean water, boiled with a large fire, and then slowly decocted with a small fire for 40 minutes; the soaked tremella is added, and the decoction is continued for 10-20 minutes; Second decoction and concentration: the medicinal liquid is filtered and stored, and the medicinal residues are decocted again with 4-5 L of water for 20-30 minutes; The two medicinal liquids are combined, and the residues are removed by precise filtration with a 100-mesh filter screen; Post-decoction fragrance extraction: the filtrate is heated again to 70-80℃, and the mint leaves are added, and then covered immediately and decocted for 5-10 minutes; S03, product processing Concentration and shaping: the medicinal liquid is transferred to a stainless steel concentration pot, maltose is added, and the medicinal liquid is concentrated to 1 / 3 of the original volume under reduced pressure at 50-60℃, thereby obtaining the heat-clearing and dryness-moistening composition.

[0012] As preferred, step S03 is followed by step S04, which is: Sterilization storage: hot filling to sealed bottles, 100℃ flow through steam sterilization for 15 minutes, natural cooling and refrigerated storage.

[0013] As preferred, in step S01, the hard medicinal material soaking time is 30 min.

[0014] As preferred, in step S02, the first decocting time is 20 min.

[0015] As preferred, the paste obtained in step S03 has a water content of ≤25%.

[0016] Compared with the prior art, the technical scheme of the present application has the advantages or beneficial effects including: 1. In the formula provided by the present application: by adding polygonatum multiflorum polysaccharide which can promote mucosal repair, organic acid of prunus mume which can promote saliva secretion and activation, and tremella fuciformis gum which has the function of reducing fire and clearing heat, the effect of moistening dryness is achieved.

[0017] 2. In the composition, peppermint and taraxacum are added, menthol can make TRPM8 receptor transiently cool down, and taraxacum chlorogenic acid can inhibit the NF-κB inflammatory pathway, and after combination, the effect of clearing heat and regulating is achieved.

[0018] 3. In the preparation process: by the way of post-decocting, the loss of volatile oil can be greatly reduced. At the same time, by vacuum concentration, the heat-sensitive material (such as polygonatum multiflorum) can be prevented from browning. At the same time, by making the final product into a paste, the natural preservation time can be prolonged without adding preservatives, and the eating process is safer. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 Statistical diagram of amygdalin content results. DETAILED DESCRIPTION

[0020] The embodiments of the present application will be described in detail below with reference to the accompanying drawings and examples, so that how the present application applies technical means to solve technical problems and achieves corresponding technical effects can be fully understood and implemented. The embodiments of the present application and each feature in the examples can be combined with each other without conflict, and the formed technical scheme is within the protection scope of the present application.

[0021] It should be clear that the following described examples are only part of the examples of the present application, not all examples. Based on the examples in the present application, all other examples obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0022] Example 1: Paste preparation (core scheme) Raw materials and proportions: liquorice 100 g, tremella 25 g, almond 100 g, polygonatum 100 g, hawthorn 150 g, mint 100 g, platycodon 100 g, orange red 125 g, dandelion 100 g, Chinese plum 100 g Preparation process: Pre-treatment: after the tremella is soaked in cold water for 2 h, it is torn into pieces; the almond and platycodon are crushed through a 40-mesh sieve; the Chinese plum is cored and crushed; the polygonatum and orange red are immersed in 5 times the amount of 60°C water for 1 h (extraction rate ≥ 92%) Segmented decoction: First decoction: medicinal materials except mint + 6 L water, boiling at 100°C and then adjusting to 95°C for 45 min of micro-boiling.

[0023] Second decoction: decocting the residues + 4 L water for 30 min, and combining the filtrates (yield 78%).

[0024] pH buffer system: The filtrate is passed through a D113 cation resin column (flow rate 1 BV / h), and the pH is adjusted to 5.8 ± 0.2; Low-temperature concentration: vacuum concentration (80°C / -0.085 MPa) to 38°Bé Baume; adding mint essential oil (the mint essential oil can be embedded by β-cyclodextrin, with an encapsulation rate of 94%); Casting: 110°C normal temperature and normal pressure casting to hanging flag shape, with a water content of 24.7%.

[0025] Product characteristics: dark brown red paste, density 1.42 g / cm³, amygdalin content 1.50 mg / g.

[0026] Example 2: Sugar-free granules (raw materials are the same as in Example 1) Extraction optimization: compound enzymolysis (cellulase: pectinase = 1:2, 50°C / 3 h) is used for polygonatum and tremella.

[0027] Reduced pressure drying: the concentrated liquid is mixed with maltitol (amount 15%), and then spray dried at 60°C (inlet air temperature 160°C, outlet air temperature 75°C).

[0028] Granule forming: 0.5% magnesium stearate is added to the dry paste powder, and wet granulation is performed (20-mesh sieve).

[0029] Parameter index: moisture content ≤ 5.0%, natural melting time 120 s, menthol retention 7.55 mg / g.

[0030] Test example 1: verification of acid-base stability.

[0031] Comparison group: traditional decocted paste without pH adjustment.

[0032] Experimental group: Example 1 paste (pH = 5.79), 60°C accelerated test for 30 days, HPLC determination of amygdalin content, the results are shown inFigure 1 It can be known that the pH buffer system designed in the application can reduce the degradation rate of amygdalin. Figure 1 It can be known that the pH buffer system designed in the application can reduce the degradation rate of amygdalin.

Claims

1. A heat-clearing and dryness-moistening composition prepared based on Polygonatum odoratum and Mentha haplocalyx, characterized in that, It consists of the following components by weight: Licorice root 50-150g, white fungus 10-40g, almond 50-150g, Solomon's seal rhizome 50-150g, hawthorn 100-200g, peppermint 50-150g, platycodon root 50-150g, tangerine peel 100-200g, dandelion 50-150g, dried plum 50-150g.

2. The heat-clearing and dryness-moistening composition prepared based on Polygonatum odoratum and Mentha haplocalyx according to claim 1, characterized in that, It consists of the following components by weight: Licorice root 80-120g, white fungus 15-30g, apricot kernel 80-120g, Solomon's seal rhizome 80-120g, hawthorn 120-160g, peppermint 80-120g, platycodon root 80-120g, tangerine peel 110-140g, dandelion 80-120g, dried plum 80-120g.

3. The heat-clearing and dryness-moistening composition prepared based on Polygonatum odoratum and Mentha haplocalyx according to claim 1, characterized in that, It consists of the following components by weight: 100g licorice root, 25g white fungus, 100g almonds, 100g Solomon's seal rhizome, 150g hawthorn, 100g mint, 100g platycodon root, 125g tangerine peel, 100g dandelion, 100g dried plum.

4. The heat-clearing and dryness-moistening composition according to any one of claims 1-3, characterized in that, It also includes 100-150 grams of maltose.

5. The heat-clearing and dryness-moistening composition according to claim 4, characterized in that, The aforementioned heat-clearing and dryness-moistening composition is an ointment.

6. A method for preparing a heat-clearing and dryness-moistening composition based on Polygonatum odoratum and Mentha haplocalyx, characterized in that, Includes the following steps: S01, Preprocessing Stage Pre-treatment of white fungus: Soak white fungus in cold water for 1-2 hours until fully expanded, cut off the hard base, and tear into small pieces for later use; Soaking hard medicinal materials: Soak Polygonatum odoratum, Platycodon grandiflorus, Citrus reticulata peel, apricot kernel, and dried plum in warm water for 20-30 minutes to soften the fibrous tissue; Post-processing of volatile substances: Store mint separately in an airtight container to prevent aroma loss; S02, Decoction Process Flow First decoction: Add all the herbs except for the white fungus and mint to 8-10L of water, bring to a boil over high heat, then simmer over low heat for 40 minutes; add the soaked white fungus and continue to simmer for 10-20 minutes. Second decoction and concentration: Filter out the liquid and store it. Add 4-5L of water to the dregs and decoct again for 20-30 minutes. Combine the two solutions and filter them through a 100-mesh filter to remove any residue. Add aroma later: Reheat the filtrate to 70-80℃, add mint leaves, immediately cover and simmer for 5-10 minutes; S03, Finished Product Processing Concentration and finalization: The medicinal liquid is transferred to a stainless steel concentrator, maltose is added, and the liquid is concentrated under reduced pressure at 50-60℃ to 1 / 3 of the original volume, thus obtaining the heat-clearing and dryness-moistening composition.

7. The preparation method according to claim 6, characterized in that, Step S03 is followed by step S04, which is as follows: Sterilization and storage: Hot fill into sealed bottles, sterilize with flowing steam at 100°C for 15 minutes, and store under cold storage after natural cooling.

8. The preparation method according to claim 6, characterized in that, In step S01, the soaking time for hard medicinal materials is 30 minutes.

9. The preparation method according to claim 6, characterized in that, In step S02, the initial decoction time is 20 minutes.

10. The preparation method according to claim 6, characterized in that, The ointment obtained in step S03 has a water content of ≤25%.

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