A collision reaction cell for inductively coupled plasma mass spectrometer

Abstract

The application relates to a collision reaction cell for an inductively coupled plasma mass spectrometer applied to the field of mass spectrometers, which comprises a shell, through holes are formed in the two ends of the shell, the inner walls of the two ends of the shell are fixedly connected with incomplete tracks, and eight sliding blocks are arranged on the incomplete tracks. The biggest advantage of the collision reaction cell is that the electric field form can be flexibly controlled to adapt to different reaction requirements. When the number of poles is small, for example, a quadrupole rod structure is used, the electric field gradient is steep, has strong radial focusing effect, is favorable for efficient transmission of ions, and improves ion flux. When more poles are used, for example, a sextupole or an octupole is used, the electric field becomes more uniform and soft, the distribution of ions in the reaction cell is wider, the ions are favorable for fully contacting with reaction gas, and thus the reaction efficiency is improved. Through pole number adjustment, the spatial electric field distribution of the reaction cell can be set as required, and the reaction cell can be flexibly switched between fast transmission and sufficient reaction.

Description

TECHNICAL FIELD

[0001] The present application relates to a collision reaction cell, in particular to a collision reaction cell for inductively coupled plasma mass spectrometer applied in the field of mass spectrometer. BACKGROUND

[0002] The collision reaction cell of the mass spectrometer is a functional area between the ion source and the mass analyzer, by introducing inert gas (such as argon) or reaction gas (such as ammonia, oxygen, etc.), using the collision or chemical reaction of ions and gas molecules to remove interfering ions, change ion form or adjust energy distribution, so as to improve the selectivity, sensitivity and accuracy of analysis.

[0003] The Chinese patent application with publication number CN107026068A discloses an inductively coupled plasma mass spectrometer and a collision reaction cell, ions enter between a plurality of electrode rods through an ion inlet, and are discharged through an ion outlet. The Chinese patent application with publication number CN104347342A discloses an ion guiding device and a collision reaction cell for mass spectrometer, ions are processed through the ion channel formed by the space surrounded by four electrode rods.

[0004] The above collision reaction cells all use the ion channel composed of fixed electrode rods to process ions, the ion channel composed of a single number of electrode rods has relatively single effect and cannot be flexibly adjusted according to different analysis requirements. For example, when facing complex samples or changing interference components, the fixed electrode number structure lacks self-adaptive adjustment ability and cannot optimize key parameters such as ion residence time and orbit distribution in real time, which easily leads to insufficient interference removal, and therefore needs to be further improved. SUMMARY

[0005] In view of the above prior art, the technical problem to be solved by the present application is that the ion channel composed of a single number of electrode rods has relatively single effect and cannot be flexibly adjusted according to different analysis requirements.

[0006] To solve the above problems, the present application provides a collision reaction cell for inductively coupled plasma mass spectrometer, which comprises an outer shell, a through hole is formed at both ends of the outer shell, an incomplete orbit is fixedly connected to the inner wall of both ends of the outer shell, eight sliding blocks are arranged on the incomplete orbit, one of the sliding blocks is fixedly connected to the head end of the incomplete orbit, and the other seven sliding blocks are slidingly connected to the incomplete orbit, a straight orbit is fixedly connected to the tail end of the incomplete orbit, a driving block is slidingly connected to the straight orbit, a shaft is fixedly connected to the side wall of the sliding block and the driving block, a telescopic rod is rotationally connected between every two adjacent shafts, a connecting disc is fixedly connected to one end of the sliding block, an electrode rod is fixedly connected to one end of the connecting disc, a receiving frame is fixedly connected to the bottom end of the outer shell, the straight orbit is located in the receiving frame and is fixedly connected thereto, and a driver is fixedly connected to the driving block, and the driver is used to drive the driving block to move along the straight orbit.

[0007] As a further improvement of the present application, the telescopic rod comprises a strip tube, an inner wall of the strip tube is fixedly connected with an inner tube, an inner wall of the inner tube is slidably connected with a driving piston, a top end of the driving piston is fixedly connected with a lifting rod.

[0008] As a further improvement of the present application, the inner side wall of the strip tube is fixedly connected with a plurality of guide rods, the plurality of guide rods are slidably connected with a ring disc, and the bottom end of the strip tube is fixedly connected with a motor.

[0009] As a further improvement of the present application, the output end of the motor is fixedly connected with a lead screw, the lead screw penetrates through the ring disc and is threadedly connected therewith, a plurality of connecting rods are fixedly connected between the ring disc and the top end of the driving piston.

[0010] As a further improvement of the present application, the inside of the sliding block is provided with a linkage cavity, an inner wall of the linkage cavity is slidably connected with a driven piston, one end of the driven piston is fixedly connected with a length-adjusting rod, and the connecting disc is fixedly connected with the length-adjusting rod.

[0011] As a further improvement of the present application, a transmission pipe is communicated between the linkage cavity and the inner tube, the transmission pipe is made of flexible material, and transmission liquid is filled between the driving piston and the driven piston.

[0012] As a further improvement of the present application, the connection between the incomplete track and the straight track is provided as a turning area.

[0013] As a further improvement of the present application, twelve positioning sensors are fixedly connected to the inner side wall of the shell close to the incomplete track, and the positioning sensors are composed of four uniformly distributed four-level sensors, six uniformly distributed six-level sensors and eight uniformly distributed eight-level sensors.

[0014] To sum up, the variable number of pole structure is adopted in the collision reaction cell, the biggest advantage is that the electric field form can be flexibly controlled to adapt to different reaction requirements, when the number of poles is small, for example, four-pole structure is used, the electric field gradient is steep, and the radial focusing effect is strong, which is beneficial to efficient transmission of ions and improves ion flux, and when more poles are used, such as six-pole or eight-pole, the electric field becomes more uniform and soft, so that the distribution of ions in the reaction cell is wider, which is beneficial to sufficient contact with the reaction gas, thereby improving the reaction efficiency, through the adjustment of the number of poles, the spatial electric field distribution of the reaction cell can be "set as needed", and the reaction cell can be flexibly switched between fast transmission and sufficient reaction;

[0015] Meanwhile, the ion residence time can be regulated. The electric field formed by different numbers of poles affects the axial velocity distribution and focusing ability of ions. By increasing the number of poles, the migration speed of ions can be moderately slowed down, the residence time of ions in the reaction cell is prolonged, the interaction probability with the reaction gas is enhanced, and the reaction selectivity is improved. When fast passing is needed to reduce side reactions, the number of poles can be reduced, the electric field focusing is enhanced, and the ions pass through the cell body faster. The adjustable number of poles provides a new dimension for the optimization of ion-gas reaction mechanism.

[0016] The variable number of pole structure improves the compatibility of the reaction cell for multiple modes. The traditional fixed number of pole structure is usually adapted to a certain type of reaction or working mode, while the structure with switchable number of poles can freely switch between collision mode, reaction mode and mass filtering mode according to the analysis task, realize one-pool multi-use, and improve the utilization rate and versatility of the instrument. BRIEF DESCRIPTION OF DRAWINGS

[0017] Figure 1 is a front view of the shell in the first embodiment of the present application;

[0018] Figure 2 is a perspective view of the shell in the first and second embodiments of the present application;

[0019] Figure 3 is a perspective view of the pole in the first and second embodiments of the present application;

[0020] Figure 4 is a perspective view of the incomplete track in the first and second embodiments of the present application;

[0021] Figure 5 is a state diagram when the number of poles is eight in the first and second embodiments of the present application;

[0022] Figure 6 is a state diagram when the number of poles is four in the first and second embodiments of the present application;

[0023] Figure 7 is a front view of the telescopic rod in the second embodiment of the present application;

[0024] Figure 8 is a front view of the sliding block in the second embodiment of the present application;

[0025] Figure 9 is a front view of the positioning sensor in the second embodiment of the present application;

[0026] Figure 10 is a front view of the four-stage sensor in the second embodiment of the present application;

[0027] Figure 11Front view at the six-stage sensor for the second embodiment of the application;

[0028] Figure 12 Front view at the eight-stage sensor for the second embodiment of the application.

[0029] Explanation of reference numerals in the drawings:

[0030] 1, shell; 101, through hole; 2, incomplete track; 201, sliding block; 202, rotating shaft; 203, telescopic rod; 204, connecting disc; 205, pole rod; 3, storage frame; 4, straight track; 5, driving block; 6, turning area; 7, positioning sensor; 701, four-stage sensor; 702, six-stage sensor; 703, eight-stage sensor; 8, driver; 9, strip tube; 901, inner tube; 902, active piston; 903, lifting rod; 904, guide rod; 905, ring disc; 906, motor; 907, connecting rod; 908, lead screw; 10, linkage cavity; 1001, passive piston; 1002, length adjustment rod; 11, transmission tube. DETAILED DESCRIPTION

[0031] The two embodiments of the application will be described in detail below with reference to the drawings.

[0032] First embodiment:

[0033] Figures 1-6 A collision reaction cell for inductively coupled plasma mass spectrometer is shown, comprising a shell 1, through holes 101 are formed at both ends of the shell 1, incomplete tracks 2 are fixedly connected to the inner walls of both ends of the shell 1, eight sliding blocks 201 are arranged on the incomplete tracks 2, one of the sliding blocks 201 is fixedly connected to the head end of the incomplete track 2, and the remaining seven sliding blocks 201 are slidingly connected to the incomplete track 2, a straight track 4 is fixedly connected to the tail end of the incomplete track 2, a driving block 5 is slidingly connected to the straight track 4, rotating shafts 202 are fixedly connected to the side walls of the sliding blocks 201 and the driving block 5, telescopic rods 203 are rotationally connected between every two adjacent rotating shafts 202, a connecting disc 204 is fixedly connected to one end of the sliding block 201, a pole rod 205 is fixedly connected to one end of the connecting disc 204, a storage frame 3 is fixedly connected to the bottom end of the shell 1, the straight track 4 is located inside the storage frame 3 and is fixedly connected thereto, a driver 8 is fixedly connected to the driving block 5, the driver 8 is used to drive the driving block 5 to move along the straight track 4, and the connection between the incomplete track 2 and the straight track 4 is set as a turning area 6.

[0034] When the cell works, multiple pole rods 205 are started to form an electric field between the multiple pole rods 205, ions enter between the multiple pole rods 205 from one end of the shell 1, and are discharged from the other end of the shell 1, so that the ions are processed.

[0035] When the plurality of telescopic rods 203 are simultaneously extended, the distance between the plurality of sliders 201 increases, and the driver 8 drives the driving block 5 to move downward. Since the length of the incomplete track 2 does not change, the slider 201 at the tail end of the incomplete track 2 moves to the straight track 4. At this time, by controlling the length of the telescopic rod 203, the number of sliders 201 remaining on the incomplete track 2 can be controlled. The number of sliders 201 on the incomplete track 2 can be kept at 4, 6, or 8, and the pole 205 entering the storage frame 3 stops working.

[0036] The biggest advantage of the variable number of pole structure in the collision reaction cell is that the electric field pattern can be flexibly controlled to adapt to different reaction requirements. When the number of poles is small, for example, four-pole structure is used, the electric field gradient is steep, which has strong radial focusing effect, is beneficial to efficient transmission of ions, and improves ion flux. When more poles are used, such as six-pole or eight-pole, the electric field becomes more uniform and soft, which makes the distribution of ions in the reaction cell more extensive, and is beneficial to sufficient contact with the reaction gas, thereby improving the reaction efficiency. Through the adjustment of the number of poles, the spatial electric field distribution of the reaction cell can be "set as needed", and the reaction cell can be flexibly switched between fast transmission and sufficient reaction.

[0037] At the same time, the ion residence time can be controlled. The electric field formed by different numbers of poles will affect the axial velocity distribution and focusing ability of ions. By increasing the number of poles, the migration speed of ions can be moderately slowed down, and the residence time of ions in the reaction cell can be prolonged, thereby enhancing the interaction probability with the reaction gas and improving the reaction selectivity. When fast passing is required to reduce side reactions, the number of poles can be reduced, so that the electric field focusing is enhanced, and the ions pass through the cell body faster. The adjustable number of poles provides a new dimension for the optimization of ion-gas reaction mechanism.

[0038] The variable number of pole structure improves the compatibility of the reaction cell for multiple modes. The traditional fixed number of pole structure is usually only suitable for a certain type of reaction or working mode. The structure with switchable number of poles can freely switch between collision mode, reaction mode, and mass filtering mode according to the analysis task, realize one cell with multiple functions, and improve the utilization rate and versatility of the instrument.

[0039] Second embodiment:

[0040] Figures 2-12A collision reaction cell for inductively coupled plasma mass spectrometer is shown, and different from the first embodiment, the telescopic rod 203 comprises a strip tube 9, the inner wall of the strip tube 9 is fixedly connected with an inner tube 901, the inner wall of the inner tube 901 is slidably connected with a driving piston 902, the top end of the driving piston 902 is fixedly connected with a lifting rod 903, the inner side wall of the strip tube 9 is fixedly connected with a plurality of guide rods 904, the plurality of guide rods 904 are slidably connected with a ring disc 905, the bottom end of the strip tube 9 is fixedly connected with a motor 906, the output end of the motor 906 is fixedly connected with a lead screw 908, the lead screw 908 penetrates through the ring disc 905 and is threadedly connected with the ring disc 905, a plurality of connecting rods 907 are fixedly connected between the ring disc 905 and the top end of the driving piston 902.

[0041] Through the above setting, the motor 906 can drive the driving piston 902 to move up and down when the motor 906 is reversed, and the driving piston 902 drives the lifting rod 903 to rise and fall when the driving piston 902 moves up and down, so as to change the length of the telescopic rod 203.

[0042] The inside of the sliding block 201 is provided with a linkage cavity 10, the inner wall of the linkage cavity 10 is slidably connected with a driven piston 1001, one end of the driven piston 1001 is fixedly connected with a length adjusting rod 1002, the connecting disc 204 is fixedly connected with the length adjusting rod 1002, a transmission pipe 11 is communicated between the linkage cavity 10 and the inner tube 901, the transmission pipe 11 is made of flexible material, and transmission liquid is filled between the driving piston 902 and the driven piston 1001.

[0043] Through the above setting, when the number of pole rods 205 located on the incomplete track 2 is adjusted by changing the length of the telescopic rod 203, the driving piston 902 moves up and down, and the driving piston 902 drives the driven piston 1001 to move left and right under the action of the transmission liquid, so as to change the distance between the plurality of pole rods 205, which can better adapt to different effects of quantum.

[0044] The housing 1 is fixedly connected with twelve positioning sensors 7 near the inner side wall of the incomplete track 2, and the positioning sensors 7 are composed of four four-level sensors 701, six six-level sensors 702 and eight eight-level sensors 703 which are uniformly distributed.

[0045] Through the above setting, after the sliding block 201 is distributed and formed, the positioning sensors 7 can play a positioning detection role on different distribution and formed pole rods 205 through the four-level sensors 701, the six-level sensors 702 and the eight-level sensors 703, so that the pole rods 205 can be found and treated in time after deviation.

[0046] In combination with the current actual demand, the above-mentioned embodiments adopted by the present application do not limit the protection scope, and various changes made within the knowledge range of those skilled in the art without departing from the concept of the present application still fall within the protection scope of the present application.

Claims

1. A collision reaction cell for an inductively coupled plasma mass spectrometer, comprising a housing (1), characterized in that: Both ends of the outer shell (1) are provided with through holes (101). The inner walls of both ends of the outer shell (1) are fixedly connected with incomplete tracks (2). Eight sliders (201) are provided on the incomplete tracks (2). One slider (201) is fixedly connected to the first end of the incomplete track (2), and the other seven sliders (201) are slidably connected to the incomplete track (2). The tail end of the incomplete track (2) is fixedly connected with a straight track (4). A driving block (5) is slidably connected on the straight track (4). The side walls of the sliders (201) and the driving block (5) are... All are fixedly connected to a rotating shaft (202), and a telescopic rod (203) is rotatably connected between every two adjacent rotating shafts (202). One end of the slider (201) is fixedly connected to a connecting plate (204), and one end of the connecting plate (204) is fixedly connected to an pole rod (205). The bottom end of the outer shell (1) is fixedly connected to a storage frame (3). The straight track (4) is located inside the storage frame (3) and fixedly connected to it. The drive block (5) is fixedly connected to a driver (8), and the driver (8) is used to drive the drive block (5) to move along the straight track (4). By controlling the length of the telescopic rod (203), the number of sliders (201) remaining on the incomplete track (2) can be controlled. The number of sliders (201) on the incomplete track (2) is 4, 6 or 8, and the pole rod (205) that enters the storage box (3) stops working.

2. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 1, characterized in that: The telescopic rod (203) includes a strip tube (9), an inner tube (901) is fixedly connected to the inner wall of the strip tube (9), an active piston (902) is slidably connected to the inner wall of the inner tube (901), and a lifting rod (903) is fixedly connected to the top end of the active piston (902).

3. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 2, characterized in that: Multiple guide rods (904) are fixedly connected to the inner wall of the tube (9), and a ring disc (905) is slidably connected between the multiple guide rods (904). A motor (906) is fixedly connected to the bottom end of the tube (9).

4. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 3, characterized in that: The output end of the motor (906) is fixedly connected to a lead screw (908), which passes through the ring disc (905) and is threadedly connected to it. Multiple connecting rods (907) are fixedly connected between the top end of the ring disc (905) and the active piston (902).

5. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 4, characterized in that: Each slider (201) has a linkage cavity (10) inside. A passive piston (1001) is slidably connected to the inner wall of the linkage cavity (10). An adjusting rod (1002) is fixedly connected to one end of the passive piston (1001). The connecting plate (204) is fixedly connected to the adjusting rod (1002).

6. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 5, characterized in that: A transmission pipe (11) is connected between the linkage cavity (10) and the inner tube (901). The transmission pipe (11) is made of flexible material, and transmission fluid is filled between the active piston (902) and the passive piston (1001).

7. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 1, characterized in that: The junction of the incomplete track (2) and the straight track (4) is set as a turning area (6).

8. The collision reaction cell for an inductively coupled plasma mass spectrometer according to claim 1, characterized in that: The outer shell (1) is fixedly connected to the inner wall of the incomplete track (2) with twelve positioning sensors (7). The positioning sensors (7) consist of four uniformly distributed level 4 sensors (701), six uniformly distributed level 6 sensors (702), and eight uniformly distributed level 8 sensors (703).

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