An anti-aging skin composition and a method for preparing the same

Abstract

The application discloses an anti-aging skin composition and a preparation method thereof. The anti-aging skin composition comprises glycerol, dipropylene glycol, trehalose, horny goat weed extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, sodium hyaluronate, caprylic / capric triglyceride, isononyl isononanoate, phytosterol, white pool seed oil, an emulsifier, a thickening stabilizer, superoxide dismutase, fullerene, ergothioneine, a penetration regulator, a pH regulator, a preservative and deionized water. The application completely discards the existing formula system, introduces brand-new core efficacy components, and has multiple anti-aging, repairing and skin tendering effects through the design of constructing a complete pathway of "telomere protection-signal activation-antioxidation-barrier repair-energy supplement" for synergistic anti-aging, realizes excellent anti-wrinkle, lifting, moisturizing and skin quality improvement effects, and the product is stable and safe.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-aging and skin-rejuvenating composition with multiple anti-aging, repairing and skin-rejuvenating effects, and its preparation method. Background Technology

[0002] Skin aging is a complex physiological process, mainly manifested as wrinkles, skin laxity, loss of elasticity, dryness and roughness, and pigmentation. Its internal mechanisms include telomere shortening, cell senescence, genomic instability, epigenetic changes, loss of protein homeostasis, nutrient sensing disorders, mitochondrial dysfunction, and changes in intercellular communication. External factors such as ultraviolet radiation (photoaging), pollution, and unhealthy lifestyle habits can accelerate this process.

[0003] Currently, most anti-aging skincare products on the market focus on a single pathway, such as supplementing collagen, providing strong antioxidant effects, or simply moisturizing. For example, Chinese invention patent application CN117159438A discloses an anti-aging and skin-rejuvenating complex with complex ingredients, including Bifida Ferment Lysate, various ceramides, hydroxypropyl tetrahydropyranotriol, and other common functional ingredients. However, such formulations have the following shortcomings: (1) The ingredients are too complex, the synergistic effect between the ingredients is unclear, and it may increase the risk of skin sensitization; (2) There is insufficient attention to deep anti-aging mechanisms such as cellular energy metabolism and telomere protection; (3) Ceramides and other ingredients are expensive, and the compatibility of chemically synthesized ceramides with the skin needs to be further improved.

[0004] Therefore, there is an urgent need in this field to develop an anti-aging and skin-rejuvenating composition with a scientifically designed formula, a clear mechanism of action, targeting multiple aging pathways, and excellent stability and safety. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a novel anti-aging and skin-rejuvenating composition with synergistic effects and good stability, as well as its preparation method. By constructing a complete pathway of "telomere protection-signal activation-antioxidation-barrier repair-energy replenishment" for synergistic anti-aging, it has multiple anti-aging, repair and skin-rejuvenating effects, achieving excellent anti-wrinkle, lifting, moisturizing and skin texture improvement effects, and the product is stable and safe.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] In a first aspect, the present invention provides an anti-aging and skin-rejuvenating composition, comprising, by weight percentage: 3.0%~8.0% glycerin, 2.0%~5.0% dipropylene glycol, 1.0%~3.0% trehalose, 0.5%~2.0% Cynomorium songaricum extract, 0.05%~0.2% acetyl tetrapeptide-11, and palmitoyl tripeptide-38. 0.05%~0.2%, sodium hyaluronate 0.05%~0.3%, caprylic / capric triglycerides 3.0%~10.0%, isononyl isononanoate 1.0%~5.0%, phytosterols 0.1%~0.5%, meadowfoam seed oil 0.5%~2.0%, emulsifier 2.4%~6%, thickener and stabilizer 0.5%~2.0%, superoxide dismutase 0.01%~0.1%, fullerene 0.1%~0.5%, ergothioneine 0.05%~0.2%, osmotic conditioner 0.5%~2.0%, pH adjuster 0.1%~0.3%, preservative 0.45%~1.2%, and the balance being deionized water.

[0008] In some specific technical solutions, the anti-aging and skin-rejuvenating composition, by weight percentage, includes the following components: 5% glycerin, 3% dipropylene glycol, 2% trehalose, 1% Cynomorium songaricum extract, 0.1% acetyl tetrapeptide-11, 0.1% palmitoyl tripeptide-38, 0.1% sodium hyaluronate, 6% caprylic / capric triglyceride, 3% isononyl isononanoate, 0.2% phytosterols, 1% meadowfoam seed oil, 4% emulsifier, 1% thickener and stabilizer, 0.05% superoxide dismutase, 0.3% fullerene, 0.1% ergothioneine, 1% penetration regulator, 0.2% pH regulator, 0.75% preservative, and the balance being deionized water.

[0009] In some specific technical solutions, the fullerene is a water-soluble fullerene. Water-soluble fullerene, through the dispersion effect of water-soluble polymer PVP, forms a water-soluble cosmetic raw material that can absorb free radicals in the human body. This not only helps repair cell damage but also stimulates cell regeneration and accelerates cell metabolism, thereby effectively combating skin aging.

[0010] In some specific technical solutions, the emulsifier is composed of cetearyl oleate / sorbitan oleate and cetearyl oleate in a mass ratio of 3:1.

[0011] In some specific technical solutions, the thickening stabilizer is sodium acryloyl dimethyl taurate / VP copolymer.

[0012] In some specific technical solutions, the osmosis regulator is trimethylglycine.

[0013] In some specific technical solutions, the pH adjuster is at least one of citric acid, sodium benzoate, and potassium sorbate.

[0014] In some specific technical solutions, the preservative is composed of 1,2-hexanediol and octyl glycol in a mass ratio of 2:1.

[0015] The overall design concept of the formulation of this invention is as follows: This invention adopts a multi-level, multi-target anti-aging design. By carefully selecting core components of each pathway, a complete anti-aging network from the cellular level to the epidermal level is constructed, including deep protection and activation, signal regulation and repair, powerful anti-oxidation, barrier repair and moisturizing, and cell energy replenishment. This avoids the simple accumulation of ingredients and achieves synergistic effects.

[0016] Specifically, the specific functions and effects of each component are explained in detail below:

[0017] (1) Deep protection and activation components

[0018] Cynomorium extract: Rich in Cynomorium polysaccharides, it can act as a plant telomere protectant, mimicking the effect of calorie restriction, activating Sirtuins (such as SIRT1 and SIRT6), and increasing telomerase activity. This inhibits telomere shortening, which is the cell's "biological clock," and protects telomere length, directly delaying the process of cellular replication-based aging. It can also enhance cellular resistance to stress, improving skin vitality from the root.

[0019] (2) Signal regulation and repair components

[0020] Acetyl tetrapeptide-11: As a signaling peptide, it can mimic collagen fragments, send repair signals to skin fibroblasts, promote the synthesis of type I and type III collagen, effectively reduce the depth and number of wrinkles, and improve skin firmness.

[0021] Palmitoyl tripeptide-38: works synergistically with acetyl tetrapeptide-11. This peptide can specifically promote the synthesis of type IV collagen and laminin, strengthen the basement membrane structure, and improve skin elasticity and firmness. The combination of the two can produce a synergistic effect.

[0022] (3) Highly effective antioxidant network components

[0023] Superoxide dismutase (SOD): As a primary antioxidant enzyme, it can efficiently catalyze the conversion of superoxide anion free radicals into hydrogen peroxide and oxygen, directly scavenging primary products of oxidative stress and reducing cell damage.

[0024] Fullerenes: A potent antioxidant with a unique cage-like structure that acts like a "free radical sponge" to continuously adsorb and neutralize various free radicals (such as hydroxyl radicals and superoxide anions), providing long-lasting and stable antioxidant protection, far exceeding the effects of traditional antioxidants.

[0025] Ergothioneine: an antioxidant derived from natural amino acids. It can penetrate cell membranes and exert antioxidant effects inside cells, protecting mitochondrial function, reducing DNA damage, and forming a synergistic antioxidant defense network with SOD and fullerenes.

[0026] (4) Barrier repair and moisturizing components

[0027] Glycerin: As a classic moisturizer, it captures moisture from the environment through its hygroscopic properties, maintains the hydration of the stratum corneum, keeps the skin moist, improves dry and rough skin, and repairs the skin barrier function.

[0028] Dipropylene glycol: As a moisturizer and solvent, it has both moisturizing and penetration-enhancing effects, helping other active ingredients to be better absorbed by the skin while providing a refreshing skin feel.

[0029] Trehalose: A natural small-molecule sugar that acts as a natural moisturizer. It can form a protective hydration film on the cell surface to prevent moisture loss and improve cell survival under stresses such as dryness and ultraviolet radiation, thus having an anti-stress effect.

[0030] Sodium hyaluronate: As a highly effective moisturizer, sodium hyaluronate of different molecular weights can lock in and replenish moisture in both the surface and deep layers of the skin. Among them, low molecular weight sodium hyaluronate can penetrate into the dermis to promote repair, while high molecular weight sodium hyaluronate forms a water-locking film in the epidermis. Through the synergistic effect of sodium hyaluronate of multiple molecular weights, three-dimensional moisturizing is achieved, wrinkles are filled, and skin texture is improved.

[0031] Phytosterols: Their structure is similar to cholesterol, which can mimic skin lipids, embed themselves in the skin lipid bilayer, repair damaged skin barriers, reduce transepidermal water loss, and have anti-inflammatory properties.

[0032] Meadowfoam seed oil: An extremely stable plant oil, rich in long-chain fatty acids and antioxidants, which can form a soft protective film on the skin surface, providing long-lasting hydration, protecting the skin from oxidative damage, and enhancing the stability of other fat-soluble active ingredients.

[0033] (5) Cellular energy replenishment components

[0034] Trimethylglycine: It acts as an osmotic regulator. As an osmotic compensating solute, it can stabilize protein structure, provide energy to cells (as a methyl donor), enhance cell vitality under osmotic stress, and improve the skin's hydration capacity.

[0035] (6) Basic and auxiliary components

[0036] Deionized water: serves as a solvent and carrier, ensuring that all components are uniformly dispersed and stably exist.

[0037] Caprylic / capric triglycerides: Light synthetic oils that give the product good spreadability and moisturizing feel without being greasy.

[0038] Isonononyl isononanoate: Improves product texture, making it smooth and easy to apply, enhancing the user experience.

[0039] Cetearyl oleate / sorbitan oleate: A natural emulsifier system derived from olive oil, gentle yet highly effective, forming a stable O / W emulsion structure while providing additional moisturizing benefits. Emulsification effectively repairs the skin barrier function, reduces damage from external irritants, and provides long-lasting hydration.

[0040] Cetearyl oleate: As an emulsifier and emollient, derived from olive oil, it provides gentle emulsification and skin-softening effects.

[0041] Sodium acryloyldimethyl taurate / VP copolymer: As a thickener and stabilizer, it imparts suitable viscosity to the product, enhances emulsion stability, and prevents stratification and sedimentation during storage.

[0042] Citric acid, 1,2-hexanediol, and caprylyl glycol constitute a mild pH-regulating and preservative system. Citric acid maintains the product's pH within the skin's physiological range (approximately 5.5–6.0), reducing irritation and enhancing stability. 1,2-hexanediol and caprylyl glycol work synergistically to provide broad-spectrum antibacterial activity while also offering moisturizing benefits, replacing traditional irritating preservatives.

[0043] Secondly, the present invention further provides a method for preparing the above-mentioned anti-aging and skin-rejuvenating composition, comprising the following steps:

[0044] S1. Mix deionized water, glycerin, dipropylene glycol, trehalose, sodium hyaluronate, and osmotic regulator, heat to 75℃~78℃, and stir homogenously to obtain the aqueous phase component;

[0045] S2. Mix caprylic / capric triglyceride, isononyl isononanoate, emulsifier, phytosterol, and meadowfoam seed oil, and heat to 75℃~78℃ to dissolve, to obtain the oil phase component;

[0046] S3. Add the oil phase component to the aqueous phase component under stirring, and perform high-speed homogenization and emulsification;

[0047] S4. Cool down to below 45℃, add thickener and stabilizer, and stir well;

[0048] S5. Continue cooling to below 40℃, then add Cynomorium extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, superoxide dismutase, fullerene, and ergothioneine in sequence, and stir well.

[0049] S6. Add pH adjuster and preservative, and stir until completely homogeneous;

[0050] S7. Cool down to below 30°C and discharge to obtain the anti-aging and skin-rejuvenating composition.

[0051] In some specific technical solutions, in step S3, the rotation speed of the high-speed homogenization emulsification is 4000 rpm to 6000 rpm, and the time is 3 min to 6 min.

[0052] Compared with the prior art, the present invention provides an anti-aging and skin-rejuvenating composition and its preparation method, which has the following beneficial effects:

[0053] 1. This invention completely abandons the existing formula system and introduces entirely new core active ingredients, forming a multi-level, multi-target anti-aging design:

[0054] (1) Deep protection and activation: By using Cynomorium extract, the calorie restriction effect is simulated to activate Sirtuins longevity proteins, protect telomeres, and delay the aging process at the cellular level.

[0055] (2) Signal regulation and repair: A novel signal peptide combination was constructed by synergistic action of acetyl tetrapeptide-11 and palmitoyl tripeptide-38 to mimic collagen fragments and send repair signals to fibroblasts, promoting the synthesis of type I, III, and IV collagen and laminin, effectively improving wrinkles and enhancing skin firmness.

[0056] (3) Powerful antioxidant network: A powerful antioxidant network combination consisting of superoxide dismutase, fullerene and ergothioneine was constructed. Superoxide dismutase first removes superoxide anions, fullerene acts as a "free radical sponge" to continuously remove various free radicals, and ergothioneine provides intracellular protection. The three work together to comprehensively resist oxidative stress damage.

[0057] (4) Barrier repair and moisturizing: Phytosterols and meadowfoam seed oil work synergistically to mimic skin lipids and repair the skin barrier. Trehalose and trimethylglycine form a natural moisturizing complex that forms a protective film around cells for long-lasting hydration. Sodium hyaluronate locks in and replenishes moisture at different molecular levels.

[0058] (5) Cellular energy replenishment: Trimethylglycine, as an osmotic regulator, can also provide energy for cells and enhance cell vitality.

[0059] 2. Simplified and Efficient Formula: This invention avoids simply piling up ingredients. By carefully selecting core components for each pathway and optimizing their proportions, it achieves multi-dimensional anti-aging through "telomere protection, signal activation, anti-oxidation, barrier repair, and energy replenishment," resulting in synergistic effects and reducing potential irritation risks. For example, the Cynomorium extract protects cells, enabling them to synthesize collagen more efficiently under the guidance of peptide signals; a powerful antioxidant network creates a low-oxidative stress environment for cell repair; and barrier repair components ensure effective penetration of active ingredients and maintain the foundation of healthy skin. This synergistic effect makes the anti-aging and skin-rejuvenating composition of this invention significantly more effective than single-ingredient or simply compounded products in terms of anti-wrinkle, lifting, moisturizing, and skin texture improvement.

[0060] 3. Stable and mild process: The process adopts a milder medium and low temperature emulsification process and adds heat-sensitive active ingredients at appropriate temperature stages to maximize the bioactivity of each component, especially peptides, enzymes and plant extracts.

[0061] 4. High safety: It mainly uses ingredients from natural or biotechnology sources, which are gentle and low in irritation, and are suitable for a variety of skin types, including sensitive skin.

[0062] The anti-aging and skin-rejuvenating composition of the present invention can be applied to skin care preparations and to the development of corresponding highly effective anti-aging cosmetics. Detailed Implementation

[0063] The technical solution of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0064] The present invention will be further described in detail below through detailed embodiments.

[0065] Unless otherwise specified, the experimental methods used in the embodiments and comparative examples of this invention are conventional methods, and the raw materials and reagents used are commercially available. Those skilled in the art will understand that any equivalent product conforming to cosmetic raw material specifications can be used to implement this invention.

[0066] Example 1

[0067] This embodiment provides an anti-aging and skin-rejuvenating composition, the formulation of which is as follows (by weight percentage): 5% glycerin, 3% dipropylene glycol, 2% trehalose, 1% Cynomorium songaricum extract, 0.1% acetyl tetrapeptide-11, 0.1% palmitoyl tripeptide-38, 0.1% sodium hyaluronate, 6% caprylic / capric triglyceride, 3% isononyl isononanoate, 0.2% phytosterols, 1% meadowfoam seed oil, 4% emulsifier, 1% thickener and stabilizer, 0.05% superoxide dismutase, 0.3% fullerene, 0.1% ergothioneine, 1% penetration regulator, 0.2% pH regulator, 0.75% preservative, and the balance being deionized water.

[0068] The fullerene is a water-soluble fullerene. The emulsifier is composed of cetearyl oleate / sorbitan oleate and cetearyl oleate in a mass ratio of 3:1. The thickening and stabilizing agent is sodium acryloyl dimethyl taurate / VP copolymer. The penetration conditioner is trimethylglycine. The pH conditioner is citric acid. The preservative is composed of 1,2-hexanediol and octyl glycol in a mass ratio of 2:1.

[0069] The preparation method of this anti-aging and skin-rejuvenating composition includes the following steps:

[0070] S1. Add deionized water, glycerin, dipropylene glycol, trehalose, sodium hyaluronate, and osmotic regulator to the main pot, stir and heat to 76°C, and homogenize to obtain the aqueous phase component.

[0071] S2. Add caprylic / capric triglyceride, isononyl isononanoate, emulsifier, phytosterol, and meadowfoam seed oil to the oil phase pot, stir and heat to 78°C until completely dissolved to obtain the oil phase component;

[0072] S3. Slowly add the oil phase component to the aqueous phase component while stirring, and homogenize and emulsify at high speed of 5000 rpm for 5 min.

[0073] S4. Slowly cool to 45℃, add thickener and stabilizer, and stir well;

[0074] S5. Continue cooling to below 40℃, then add Cynomorium extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, superoxide dismutase, fullerene, and ergothioneine in sequence. Stir well after each addition.

[0075] S6. Finally, add the pH adjuster and preservative, and stir until completely homogeneous.

[0076] S7. Cool down to below 30°C and discharge to obtain the anti-aging and skin-rejuvenating composition.

[0077] Example 2

[0078] This embodiment provides an anti-aging and skin-rejuvenating composition. Unlike Example 1, the amounts of each component have been adjusted, while the rest remain unchanged. Specifically, the formulation of the anti-aging and skin-rejuvenating composition is as follows (by weight percentage): 4% glycerin, 2.5% dipropylene glycol, 1.5% trehalose, 0.8% Cynomorium songaricum extract, 0.08% acetyl tetrapeptide-11, 0.08% palmitoyl tripeptide-38, 0.08% sodium hyaluronate, 5% caprylic / capric triglyceride, 2% isononyl isononanoate, 0.15% phytosterols, 0.8% meadowfoam seed oil, 3.2% emulsifier, 0.8% thickener and stabilizer, 0.03% superoxide dismutase, 0.2% fullerene, 0.08% ergothioneine, 0.8% penetration modifier, 0.15% pH modifier, 0.6% preservative, and the balance being deionized water.

[0079] The preparation method of the anti-aging and skin-rejuvenating composition in this embodiment is the same as that in Example 1, so it will not be described again.

[0080] Example 3

[0081] This embodiment provides an anti-aging and skin-rejuvenating composition. Unlike Example 1, the amounts of each component have been adjusted, while the rest remain unchanged. Specifically, the formulation of the anti-aging and skin-rejuvenating composition is as follows (by weight percentage): 6% glycerin, 4% dipropylene glycol, 2.5% trehalose, 1.5% Cynomorium songaricum extract, 0.15% acetyl tetrapeptide-11, 0.15% palmitoyl tripeptide-38, 0.15% sodium hyaluronate, 8% caprylic / capric triglyceride, 4% isononyl isononanoate, 0.3% phytosterols, 1.5% meadowfoam seed oil, 6% emulsifier, 1.5% thickener and stabilizer, 0.08% superoxide dismutase, 0.4% fullerene, 0.15% ergothioneine, 1.8% penetration conditioner, 0.25% pH adjuster, 1.05% preservative, and the balance being deionized water.

[0082] The preparation method of the anti-aging and skin-rejuvenating composition in this embodiment is the same as that in Example 1, so it will not be described again.

[0083] Example 4

[0084] This embodiment provides an anti-aging and skin-rejuvenating composition. Unlike Example 1, the amounts of each component have been adjusted, while the rest remain unchanged. Specifically, the formulation of the anti-aging and skin-rejuvenating composition is as follows (by weight percentage): 3.5% glycerin, 2% dipropylene glycol, 1% trehalose, 0.5% Cynomorium songaricum extract, 0.05% acetyl tetrapeptide-11, 0.05% palmitoyl tripeptide-38, 0.05% sodium hyaluronate, 4% caprylic / capric triglyceride, 1.5% isononyl isononanoate, 0.1% phytosterols, 0.5% meadowfoam seed oil, 2.4% emulsifier, 0.5% thickener and stabilizer, 0.01% superoxide dismutase, 0.1% fullerene, 0.05% ergothioneine, 0.5% penetration modifier, 0.1% pH modifier, 0.45% preservative, and the balance being deionized water.

[0085] The preparation method of the anti-aging and skin-rejuvenating composition in this embodiment is the same as that in Example 1, so it will not be described again.

[0086] Example 5

[0087] This embodiment provides an anti-aging and skin-rejuvenating composition. Unlike Example 1, the amounts of each component have been adjusted, while the rest remain unchanged. Specifically, the formulation of the anti-aging and skin-rejuvenating composition is as follows (by weight percentage): 7% glycerin, 4.5% dipropylene glycol, 2.8% trehalose, 2% Cynomorium songaricum extract, 0.2% acetyl tetrapeptide-11, 0.2% palmitoyl tripeptide-38, 0.25% sodium hyaluronate, 9% caprylic / capric triglyceride, 4.5% isononyl isononanoate, 0.4% phytosterols, 1.8% meadowfoam seed oil, 4.8% emulsifier, 1.8% thickener and stabilizer, 0.1% superoxide dismutase, 0.45% fullerene, 0.18% ergothioneine, 2% penetration modifier, 0.3% pH adjuster, 1.2% preservative, and the balance being deionized water.

[0088] The preparation method of the anti-aging and skin-rejuvenating composition in this embodiment is the same as that in Example 1, so it will not be described again.

[0089] Comparative Example 1

[0090] This comparative example provides an anti-aging and skin-rejuvenating composition. Compared with Example 1, it does not contain Cynomorium extract, acetyl tetrapeptide-11, and palmitoyl tripeptide-38, and is made up with an equal amount of deionized water to reach 100%. The remaining ingredients and dosages are the same as in Example 1. The corresponding preparation method can be referred to Example 1, so it will not be repeated here.

[0091] Comparative Example 2

[0092] This comparative example provides an anti-aging and skin-rejuvenating composition. Compared with Example 1, it does not contain superoxide dismutase, fullerene, and ergothioneine, and is made up with an equal amount of deionized water to reach 100%. The remaining components and amounts are the same as in Example 1. The corresponding preparation method can be referred to in Example 1, so it will not be repeated here.

[0093] Comparative Example 3

[0094] This comparative example provides an anti-aging and skin-rejuvenating composition, obtained using the formulation and preparation method of Example 1 in invention patent application CN117159438A.

[0095] To verify the technical effectiveness of this invention, the following performance test experiments were conducted.

[0096] 1. In vitro antioxidant capacity test (DPPH free radical scavenging rate)

[0097] Take 0.1 g of the samples prepared in Examples 1-5 and Comparative Examples 1-3 respectively, mix them with 2.9 mL of DPPH ethanol solution (0.1 mM), react in the dark for 30 minutes, and then measure the absorbance at 517 nm. Calculate the DPPH free radical scavenging rate, and the results are shown in Table 1.

[0098] Table 1: DPPH free radical scavenging rate

[0099] 2. Evaluation of human efficacy

[0100] Sixty healthy female volunteers aged 35-55 were recruited and randomly divided into eight groups. Each group used the products from Example 1, Comparative Example 1, Comparative Example 2, and Comparative Example 3, respectively, twice daily (morning and evening) for 28 consecutive days. Measurements were taken using professional skin testing equipment.

[0101] Skin elasticity: R2 value (total elasticity) is measured using a cutometer.

[0102] Skin wrinkles: The area of ​​crow's feet at the corners of the eyes was assessed using the Visioface image analysis system.

[0103] Skin moisture: The moisture content of the stratum corneum was measured using a Corneometer CM825.

[0104] The results are expressed as the improvement rate after 28 days of use (compared to day 0), and the results are shown in Table 2.

[0105] Table 2: Results of Human Efficacy Evaluation (Improvement Rate %) after 28 Days of Use

[0106] 3. Stability Test

[0107] The samples from Example 1 and Comparative Example 3 were placed in a 40℃ constant temperature incubator (accelerated test), a -15℃ freezer (cold resistance test), and at room temperature (25℃). Their appearance, color, and odor were observed after 1 month, 3 months, and 6 months, respectively, and changes in pH and viscosity were measured. Simultaneously, all samples were centrifuged (4000 rpm, 30 min) to evaluate their emulsification stability. Specific results are shown in Tables 3 and 4 below.

[0108] Table 3: Stability test results of Example 1 (initial pH 5.82, viscosity 25500 mPa·s)

[0109] Table 4: Stability test results of Comparative Example 3 (initial pH 5.9, viscosity 23800 mPa·s)

[0110] As shown in Tables 3 and 4, the sample from Example 1 exhibited excellent stability under various test conditions. After 6 months of accelerated testing at 40°C, only a slight color change was observed, and the pH and viscosity decreased slightly but by a very small margin, maintaining a good emulsified state without any stratification. All indicators remained highly stable at -15°C and room temperature.

[0111] The stability of the sample in Comparative Example 3 was significantly inferior to that of the present invention. Oil precipitation began to appear after being placed at 40°C for 3 months, and obvious stratification occurred after 6 months; it had extremely poor cold resistance at -15°C, and particles appeared after repeated freeze-thaw cycles, eventually leading to demulsification; it also showed slight exudation after being placed at room temperature for 6 months.

[0112] Analyzing the results of the above tests, we can see that:

[0113] (1) The anti-aging and skin-rejuvenating compositions prepared in Examples 1 to 5 of the present invention all exhibit excellent in vitro antioxidant capacity, which is significantly better than Comparative Example 2, which lacks core antioxidant components, and Comparative Example 3 of the prior art.

[0114] (2) Human efficacy evaluation shows that Example 1 of the present invention is most effective in improving skin elasticity, reducing wrinkles and increasing skin moisture, and is superior to Comparative Example 1 which lacks deep anti-aging ingredients, Comparative Example 2 which lacks antioxidant ingredients and Comparative Example 3 of the prior art.

[0115] (3) Stability tests have shown that the anti-aging and skin-rejuvenating composition of the present invention has significantly better physical and chemical stability than the prior art through the optimized formulation system and preparation process. It has good storage stability and can guarantee the quality and efficacy of the product within the shelf life, thus meeting the requirements for market launch.

[0116] In summary, this invention constructs a novel, multi-pathway synergistic anti-aging system through multi-level, multi-target scientific formulation design. The synergistic effect of each component achieves excellent anti-aging, skin rejuvenation and moisturizing effects, and the product is stable and safe.

[0117] The above embodiments are merely illustrative of the concept and technical solution of the present invention and are not intended to limit the present invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

[0118] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. An anti-aging and skin-rejuvenating composition, characterized in that, By weight percentage, it comprises the following components: glycerin 3.0%~8.0%, dipropylene glycol 2.0%~5.0%, trehalose 1.0%~3.0%, Cynomorium songaricum extract 0.5%~2.0%, acetyl tetrapeptide-11 0.05%~0.2%, palmitoyl tripeptide-38 0.05%~0.2%, sodium hyaluronate 0.05%~0.3%, caprylic / capric triglycerides 3.0%~10.0%, isononyl isononanoate 1.0%~5.0%, phytosterols 0.1%~0.5%, meadowfoam seed oil 0.5%~2.0%, emulsifier 2.4%~6%, thickener and stabilizer 0.5%~2.0%, superoxide dismutase 0.01%~0.1%, fullerene 0.1%~0.5%, ergothioneine 0.05%~0.2%, osmotic conditioner 0.5%~2.0%, pH adjuster 0.1%~0.3%, preservative 0.45%~1.2%, and the balance being deionized water.

2. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, By weight percentage, it comprises the following components: glycerin 5%, dipropylene glycol 3%, trehalose 2%, Cynomorium songaricum extract 1%, acetyl tetrapeptide-11 0.1%, palmitoyl tripeptide-38 0.1%, sodium hyaluronate 0.1%, caprylic / capric triglyceride 6%, isononyl isononanoate 3%, phytosterols 0.2%, meadowfoam seed oil 1%, emulsifier 4%, thickener and stabilizer 1%, superoxide dismutase 0.05%, fullerene 0.3%, ergothioneine 0.1%, osmotic conditioner 1%, pH adjuster 0.2%, preservative 0.75%, and the balance being deionized water.

3. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The fullerene is a water-soluble fullerene.

4. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The emulsifier is composed of cetearyl oleate / sorbitan oleate and cetearyl oleate in a mass ratio of 3:

1.

5. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The thickening stabilizer is sodium acryloyl dimethyl taurate / VP copolymer.

6. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The osmotic regulator is trimethylglycine.

7. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The pH adjuster is citric acid.

8. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The preservative is composed of 1,2-hexanediol and octyl glycol in a mass ratio of 2:

1.

9. A method for preparing an anti-aging and skin-rejuvenating composition according to any one of claims 1 to 8, characterized in that, Includes the following steps: S1. Mix deionized water, glycerin, dipropylene glycol, trehalose, sodium hyaluronate, and osmotic regulator, heat to 75℃~78℃, and stir homogenously to obtain the aqueous phase component. S2. Mix caprylic / capric triglyceride, isononyl isononanoate, emulsifier, phytosterol, and meadowfoam seed oil, and heat to 75℃~78℃ to dissolve, to obtain the oil phase component; S3. Add the oil phase component to the aqueous phase component under stirring, and perform high-speed homogenization and emulsification; S4. Cool down to below 45℃, add thickener and stabilizer, and stir well; S5. Continue cooling to below 40℃, then add Cynomorium extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, superoxide dismutase, fullerene, and ergothioneine in sequence, and stir well. S6. Add pH adjuster and preservative, and stir until completely homogeneous; S7. Cool down to below 30°C and discharge to obtain the anti-aging and skin-rejuvenating composition.

10. The preparation method according to claim 9, characterized in that, In step S3, the high-speed homogenization emulsification speed is 4000 rpm to 6000 rpm, and the time is 3 min to 6 min.

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