Light and thin moisturizing lip cream and preparation method thereof

Abstract

The invention relates to a light and thin moisturizing lip cream and a preparation method thereof, and belongs to the technical field of cosmetics. The light and thin moistening type lip cream is prepared from the following raw materials: meadowfoam seed oil, ceramide NP, lecithin, caprylic acid / capric triglyceride, a dendrobium officinale-tremella-glucan compound, tetrahydromethylpyrimidine carboxylic acid, 1, 3-propylene glycol, inulin, a cooling agent WS-23, vitamin E, capryloyl hydroximic acid, ethylhexylglycerin and deionized water. The prepared lip cream provides bionic barrier repair by virtue of ceramide NP wrapped by nano-liposome, has strong water locking effect of a dendrobium officinale-tremella-glucan compound, and is compounded with other components such as meadowfoam seed oil, so that multiple moisturizing repair is provided under the condition that the texture is kept light and thin.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and relates to a light and thin moisturizing lip balm and a preparation method thereof. BACKGROUND

[0002] The lip balm has a texture generally between thick paste and flowing oil, presents a cream or curd, and has a wide application range. The lip balm can be used as a lip essence in a daily skin care process, can improve the fit and texture of lip makeup when used before makeup, and can repair and protect lips, and fade lip lines when used at night. The lip balm provides more efficient and comfortable care effects for people who have been using matte lipstick for a long time, are in a dry environment, or have lip problems. However, the texture of the lip balm causes a heavy and sticky feeling when used, which greatly affects the experience of consumers. SUMMARY

[0003] The present application belongs to the technical field of cosmetics, and relates to a light and thin moisturizing lip balm and a preparation method thereof.

[0004] The purpose of the present application can be achieved by the following technical solutions.

[0005] A light and thin moisturizing lip balm, raw materials of the light and thin moisturizing lip balm include, by weight, 4-4.4 parts of white pool flower seed oil, 0.8-1.2 parts of ceramide NP, 1.4-1.6 parts of lecithin, 2.5-3.5 parts of caprylic / capric triglyceride, 9.5-10.5 parts of dendrobium officinale- tremella-fucoidan complex, 0.8-1.2 parts of tetrahydro methyl pyrimidine carboxylic acid, 4.5-5.5 parts of 1,3-propanediol, 0.4-0.6 parts of inulin, 0.08-0.12 parts of cooling agent WS-23, 0.15-0.25 parts of vitamin E, 0.04-0.1 parts of capryl hydroxamic acid, 0.3-0.5 parts of ethylhexylglycerin, and 74-76 parts of deionized water.

[0006] Further, the ceramide NP is a nano-liposome-encapsulated ceramide NP, and a preparation method of the nano-liposome-encapsulated ceramide NP includes the following steps.

[0007] A1, ceramide NP, lecithin, and cholesterol are added to a container, anhydrous ethanol is then added, stirring is performed in a 48-52℃ water bath until complete dissolution, and an organic solvent is removed by rotary evaporation to obtain a lipid film;

[0008] A2, the PBS buffer preheated to 48-52℃ is poured into the lipid film, and hydration is performed in a 48-52℃ water bath to obtain a liposome suspension.

[0009] A3, the liposome suspension is placed in an ice water bath, ultrasonic treatment, high pressure homogenization, filtration, to obtain nanoliposome wrapped ceramide NP.

[0010] Further, the mass ratio of ceramide NP, lecithin, cholesterol, anhydrous ethanol in step A1 is 1:13.5-16.5:3-5:19.5-20.5.

[0011] Further, the mass ratio of the lipid film and PBS buffer in step A2 is 1:2.5-3.5; the pH of the PBS buffer is 7.3-7.5; the hydration refers to stirring at a speed of 150-250 rpm for 2-3 h.

[0012] Further, the ultrasonic power of the ultrasonic treatment in step A3 is 300-500 W, and the ultrasonic time is 8-12 min; the high pressure homogenization refers to controlling the interval of 0.2-0.4 min before and after each homogenization cycle, first homogenizing at 750-850 bar for 3 times, each time for 2-3 min, and then homogenizing at 1150-1250 bar for 5 times, each time for 0.5-1.5 min; the filtration uses a 0.22 μm filter membrane.

[0013] Further, the preparation method of the Dendrobium officinale-Tremella fuciformis-glucan complex comprises the following steps:

[0014] B1, the Dendrobium officinale powder and deionized water are mixed, the pH is adjusted to 4.4-4.6 using citric acid, then cellulase is added, and enzyme hydrolysis is carried out at 48-52℃ for 2-3 h; after inactivation by heating, the temperature is lowered to 48-52℃ for continuous extraction for 2-3 h; the extract is separated and collected, concentrated under reduced pressure to 1 / 5 of the original volume, and then anhydrous ethanol is added under stirring to stand at 4℃ for 10-14 h; the precipitate is collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50℃ under vacuum to obtain Dendrobium officinale polysaccharide powder;

[0015] B2, the Tremella fuciformis powder and deionized water are mixed and refluxed at 94-96℃ for 3-4 h; the filtrate is separated and collected, and the two filtrates obtained after repeated extraction are combined and concentrated under reduced pressure to 1 / 5 of the original volume to obtain concentrated filtrate; then anhydrous ethanol is added under stirring to stand at 4℃ for 10-14 h; the precipitate is collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50℃ under vacuum to obtain Tremella fuciformis polysaccharide powder;

[0016] B3, the Dendrobium officinale polysaccharide powder, Tremella fuciformis polysaccharide powder, β-glucan powder and deionized water are mixed and stirred at low speed to form a uniform colloidal solution, which is then placed at 14-16℃ for 10-14 h and freeze-dried to obtain Dendrobium officinale-Tremella fuciformis-glucan complex.

[0017] Further, the mass ratio of the Dendrobium officinale powder, deionized water and cellulase in step B1 is 1:28-32:0.004-0.006; the volume ratio of the concentrated extract and anhydrous ethanol is 1:3.5-4.5.

[0018] Further, the mass ratio of the Tremella fuciformis powder and deionized water in step B2 is 1:48-52; the volume ratio of the concentrated filtrate and anhydrous ethanol is 1:2.5-3.5.

[0019] Further, the mass ratio of the Dendrobium officinale polysaccharide powder, Tremella fuciformis polysaccharide powder, beta-glucan powder and deionized water in step B3 is 4.5-5.5:7.5-8.5:1.5-2.5:290-310; the low-speed stirring refers to stirring at a speed of 80-120 rpm at room temperature.

[0020] Further, the preparation method of the light and thin moisturizing lip balm comprises the following steps:

[0021] C1, mix the white pool flower seed oil, ceramide NP, lecithin and caprylic / capric triglyceride, uniformly stir in a water bath at 73-77 DEG C, and keep warm for 8-12 min to obtain a first mixture;

[0022] C2, mix the Dendrobium officinale-Tremella fuciformis-glucan complex, tetrahydro methyl pyrimidine carboxylic acid, 1,3-propanediol and deionized water, uniformly stir in a water bath at 73-77 DEG C, and keep warm for 8-12 min to obtain a second mixture;

[0023] C3, under the stirring speed of 350-450 rpm, add the first mixture to the second mixture, and then stir at a speed of 2200-2800 rpm for 2-4 min to obtain a primary emulsion;

[0024] C4, under the stirring speed of 350-450 rpm, place the primary emulsion in an ice water bath and stir to cool to 33-37 DEG C, then add inulin and cooling agent WS-23, stir to cool to 28-32 DEG C, then add in vitamin E, capryl hydroxamic acid and ethylhexyl glycerin, at the same time, reduce the stirring speed to 180-220 rpm, adjust the pH to 5.1-5.5 and uniformly stir, vacuum degassing, filling, to obtain a light and thin moisturizing lip balm.

[0025] The beneficial effects of the present application are:

[0026] (1) The present application provides a biomimetic barrier repair by means of nanoliposome-wrapped ceramide NP, a strong water-locking effect of the Dendrobium officinale-Tremella fuciformis-glucan complex, and a complex of white pool flower seed oil and other ingredients, to provide multiple moisturizing repair while maintaining a light and thin texture.

[0027] (2) The present application provides a dendrobium officinale-tremella-polyglucosan compound, which can provide additional repair effect in the case of synergistic moisturizing and water locking, tremella polysaccharide can effectively regulate skin feeling, and beta-glucan can strengthen soothing and repair, so as to give the lips good care effect and comfortable light and thin experience. DETAILED DESCRIPTION

[0028] In order to further illustrate the technical means and effects adopted by the present application to achieve the predetermined object of the application, the specific embodiments, structures, features and effects according to the present application are described in detail as follows in combination with examples.

[0029] The white pool flower seed oil in all examples and comparative examples of the present application is purchased from Jiangxi Jian City Guoguang Fragrance Factory; the ceramide NP, lecithin (which is soybean lecithin), cholesterol and cooling agent WS-23 are purchased from Wuhan Lanya Bai Medicine and Chemical Industry Co., Ltd.; the PBS buffer is purchased from Sigma Aldrich (Shanghai) Trading Co., Ltd.; the caprylic acid / capric acid triglyceride and ethylhexylglycerin are purchased from Wuhan Smack Biological Technology Co., Ltd.; the cellulase (CAS number 9012-54-8), beta-glucan powder and tetrahydro methyl pyrimidine carboxylic acid are purchased from Shaanxi Ran'gao Biological Technology Co., Ltd.; 1,3-propanediol is purchased from Hubei Yihua New Material Technology Co., Ltd.; inulin is purchased from Xi'an Ruier Biological Engineering Co., Ltd.; vitamin E is purchased from Jiangsu Caiwei Biological Technology Co., Ltd.; caprylhydroxamic acid is purchased from Xi'an Xihai Biological Technology Co., Ltd.

[0030] Example 1

[0031] A light and thin moisturizing lip cream, the raw materials of the light and thin moisturizing lip cream comprise, by weight fraction, 4 parts of white pool flower seed oil, 0.8 parts of ceramide NP, 1.4 parts of lecithin, 2.5 parts of caprylic acid / capric acid triglyceride, 9.5 parts of dendrobium officinale-tremella-polyglucosan compound, 0.8 parts of tetrahydro methyl pyrimidine carboxylic acid, 4.5 parts of 1,3-propanediol, 0.4 parts of inulin, 0.08 parts of cooling agent WS-23, 0.15 parts of vitamin E, 0.04 parts of caprylhydroxamic acid, 0.3 parts of ethylhexylglycerin, and 74 parts of deionized water.

[0032] The ceramide NP is a nano-liposome-encapsulated ceramide NP, and the preparation method of the nano-liposome-encapsulated ceramide NP comprises the following steps:

[0033] A1, ceramide NP, lecithin and cholesterol are added to a container, then anhydrous ethanol is added, stirring is carried out in a 48℃ water bath until complete dissolution, and the organic solvent is removed by rotary evaporation to obtain a lipid film;

[0034] A2, pour the preheated PBS buffer solution at 48℃ into the lipid film, and hydrate in a 48℃ water bath to obtain a liposome suspension.

[0035] A3, the liposome suspension is placed in an ice water bath, ultrasonic treatment, high pressure homogenization, filtration, to obtain nanoliposome wrapped ceramide NP.

[0036] The mass ratio of ceramide NP, lecithin, cholesterol, anhydrous ethanol in step A1 is 1:13.5:3:19.5.

[0037] The mass ratio of the lipid film and PBS buffer in step A2 is 1:2.5; the pH of the PBS buffer is 7.3; the hydration refers to stirring at 150 rpm for 2 h.

[0038] The ultrasonic power of the ultrasonic treatment in step A3 is 300 W, and the ultrasonic time is 8 min; the high pressure homogenization refers to controlling the interval of 0.2 min before and after each homogenization cycle, first homogenizing at 750 bar for 3 times, each time for 2 min, and then homogenizing at 1150 bar for 5 times, each time for 0.5 min; the filtration uses a 0.22 μm filter membrane.

[0039] The preparation method of the Dendrobium officinale-Tremella fuciformis-glucan complex comprises the following steps:

[0040] B1, the Dendrobium officinale powder and deionized water are mixed, the pH is adjusted to 4.4 using citric acid, and then cellulase is added, and enzyme hydrolysis is carried out at 48℃ for 2 h; after inactivation by heating, the temperature is lowered to 48℃ for continuous extraction for 2 h; the extract is separated and collected, concentrated under reduced pressure to 1 / 5 of the original volume, and then anhydrous ethanol is added under stirring, and the mixture is placed at 4℃ for 10 h; the precipitate is collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50℃ under vacuum to obtain a Dendrobium officinale polysaccharide powder;

[0041] B2, the Tremella fuciformis powder and deionized water are mixed and then refluxed at 94℃ for 3 h; the filtrate is separated and collected, and the extraction is repeated once; the two filtrates obtained are combined and concentrated under reduced pressure to 1 / 5 of the original volume to obtain a concentrated filtrate; anhydrous ethanol is added under stirring, and the mixture is placed at 4℃ for 10 h; the precipitate is collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50℃ under vacuum to obtain a Tremella fuciformis polysaccharide powder;

[0042] B3, the Dendrobium officinale polysaccharide powder, the Tremella fuciformis polysaccharide powder, the β-glucan powder, and deionized water are mixed, and then stirred at low speed until a uniform colloidal solution is formed; the mixture is placed at 14℃ for 10 h and then freeze-dried to obtain a Dendrobium officinale-Tremella fuciformis-glucan complex.

[0043] The mass ratio of the Dendrobium officinale powder, deionized water, and cellulase in step B1 is 1:28:0.004; the volume ratio of the concentrated extract and anhydrous ethanol is 1:3.5.

[0044] The mass ratio of the tremella powder and deionized water in step B2 is 1:48; the volume ratio of the concentrated filtrate and anhydrous ethanol is 1:2.5.

[0045] The mass ratio of the dendrobium officinale-polysaccharide powder, the tremella polysaccharide powder, the beta-glucan powder, and the deionized water in step B3 is 4.5:7.5:1.5:290; the low-speed stirring refers to stirring at a speed of 80 rpm at room temperature.

[0046] The preparation method of the light and thin moisturizing lipstick comprises the following steps:

[0047] C1, mix the white pool flower seed oil, the ceramide NP, the lecithin, and the caprylic acid / capric acid triglyceride, stir uniformly in a water bath at 73 DEG C, and keep for 8 min to obtain a first mixture;

[0048] C2, mix the dendrobium officinale-tremella-glucan complex, the tetrahydro methyl pyrimidine carboxylic acid, the 1,3-propanediol, and the deionized water, stir uniformly in a water bath at 73 DEG C, and keep for 8 min to obtain a second mixture;

[0049] C3, under the stirring speed of 350 rpm, add the first mixture to the second mixture, stir at a speed of 2200 rpm for 2 min to obtain a preliminary emulsion;

[0050] C4, under the stirring speed of 350 rpm, place the preliminary emulsion in an ice water bath and stir to cool to 33 DEG C, then add the inulin and the cooling agent WS-23, stir to cool to 28 DEG C, then add the vitamin E, the capryl hydroxamic acid, and the ethyl hexyl glycerin, reduce the stirring speed to 180 rpm, adjust the pH to 5.1 and stir uniformly, vacuum degassing, and filling to obtain the light and thin moisturizing lipstick.

[0051] Example 2

[0052] A light and thin moisturizing lipstick, the raw materials of the light and thin moisturizing lipstick comprise, by weight fraction, 4.1 parts of white pool flower seed oil, 0.9 parts of ceramide NP, 1.45 parts of lecithin, 2.8 parts of caprylic acid / capric acid triglyceride, 9.7 parts of dendrobium officinale-tremella-glucan complex, 0.9 parts of tetrahydro methyl pyrimidine carboxylic acid, 4.8 parts of 1,3-propanediol, 0.45 parts of inulin, 0.09 parts of cooling agent WS-23, 0.18 parts of vitamin E, 0.05 parts of capryl hydroxamic acid, 0.35 parts of ethyl hexyl glycerin, and 74.5 parts of deionized water.

[0053] The preparation method of the ceramide NP wrapped in the nanoliposome comprises the following steps:

[0054] A1, adding ceramide NP, lecithin, cholesterol into the container, then adding anhydrous ethanol, stirring in 48℃ water bath until completely dissolved, rotary evaporation to remove organic solvents, to obtain a lipid film;

[0055] A2, pouring the lipid film into the preheated PBS buffer solution to 48℃, hydration in 48℃ water bath, to obtain a liposome suspension;

[0056] A3, the liposome suspension is placed in an ice water bath, ultrasonic treatment, high pressure homogenization, filtration, to obtain a nanoliposome wrapped ceramide NP.

[0057] The mass ratio of ceramide NP, lecithin, cholesterol, anhydrous ethanol in step A1 is 1:14.5:3.5:19.7.

[0058] The mass ratio of the lipid film and PBS buffer solution in step A2 is 1:2.8; the pH of the PBS buffer solution is 7.3; the hydration refers to stirring at 150 rpm for 2.2 h.

[0059] The ultrasonic power of the ultrasonic treatment in step A3 is 300 W, and the ultrasonic time is 9 min; the high pressure homogenization refers to controlling the interval of 0.2 min before and after each homogenization cycle, first homogenizing at 750 bar for 3 times, each time for 2 min, then homogenizing at 1150 bar for 5 times, each time for 0.5 min; the filtration uses a 0.22 μm filter membrane.

[0060] The preparation method of the Dendrobium officinale- Tremella fuciformis-glucan complex comprises the following steps:

[0061] B1, mixing Dendrobium officinale powder and deionized water, adjusting the pH to 4.4 with citric acid, then adding cellulase, and enzymatically hydrolyzing at 49℃ for 2.2 h, after inactivation by heating, cooling to 49℃ and continuing to extract for 2.2 h, separating and collecting the extract, concentrating under reduced pressure to 1 / 5 of the original volume, obtaining a concentrated extract, then stirring and adding anhydrous ethanol, and standing at 4℃ for 11 h, centrifuging to collect the precipitate, and dehydrating by washing with anhydrous ethanol and acetone, and vacuum drying at 50℃ to obtain Dendrobium officinale polysaccharide powder;

[0062] B2, mixing Tremella fuciformis powder and deionized water, then refluxing at 94℃ for 3.3 h, separating and collecting the filtrate, repeating the extraction once, then combining the two filtrates obtained and concentrating under reduced pressure to 1 / 5 of the original volume, obtaining a concentrated filtrate, then stirring and adding anhydrous ethanol, and standing at 4℃ for 11 h, centrifuging to collect the precipitate, and dehydrating by washing with anhydrous ethanol and acetone, and vacuum drying at 50℃ to obtain Tremella fuciformis polysaccharide powder;

[0063] B3, mixing the dendrobium officinale polysaccharide powder, the tremella polysaccharide powder, the beta-glucan powder and the deionized water, low-speed stirring to form a uniform colloidal solution, standing at 14℃ for 1h, freeze-drying to obtain the dendrobium officinale-tremella-glucan complex.

[0064] The mass ratio of the dendrobium officinale powder, the deionized water and the cellulase in step B1 is 1:29:0.004; the volume ratio of the concentrated extract and the anhydrous ethanol is 1:3.5.

[0065] The mass ratio of the tremella powder and the deionized water in step B2 is 1:49; the volume ratio of the concentrated filtrate and the anhydrous ethanol is 1:2.5.

[0066] The mass ratio of the dendrobium officinale polysaccharide powder, the tremella polysaccharide powder, the beta-glucan powder and the deionized water in step B3 is 4.8:7.7:1.8:296; the low-speed stirring refers to stirring at a speed of 80rpm at room temperature.

[0067] The preparation method of the light and thin moisturizing lip cream comprises the following steps:

[0068] C1, mixing the white pool seed oil, the ceramide NP, the lecithin and the caprylic / capric triglyceride, stirring uniformly in a water bath at 74℃, and keeping warm for 9min to obtain a first mixture;

[0069] C2, mixing the dendrobium officinale-tremella-glucan complex, the tetrahydro methyl pyrimidine carboxylic acid, the 1,3-propanediol and the deionized water, stirring uniformly in a water bath at 74℃, and keeping warm for 9min to obtain a second mixture;

[0070] C3, under the stirring speed of 350rpm, adding the first mixture into the second mixture, stirring at a speed of 2200rpm for 2.5min to obtain a primary emulsion;

[0071] C4, under the stirring speed of 350rpm, placing the primary emulsion in an ice water bath to stir and cool to 34℃, adding the inulin and the cooling agent WS-23, stirring and cooling to 29℃, adding the vitamin E, the octanoyl hydroxamic acid and the ethylhexylglycerin, at the same time reducing the stirring speed to 180rpm, adjusting the pH to 5.2 and stirring uniformly, vacuum defoaming, filling to obtain the light and thin moisturizing lip cream.

[0072] Example 3

[0073] A kind of light and thin moisturizing lip cream, the raw material of the light and thin moisturizing lip cream includes 4.2 parts white pool seed oil, 1 part ceramide NP, 1.5 parts lecithin, 3 parts caprylic acid / capric acid triglyceride, 10 parts Dendrobium officinale- Tremella fuciformis-glucan complex, 1 part tetrahydro methyl pyrimidine carboxylic acid, 5 parts 1,3-propanediol, 0.5 parts inulin, 0.1 parts cooling agent WS-23, 0.2 parts vitamin E, 0.07 parts octanoyl hydroxamic acid, 0.4 parts ethylhexyl glycerin, 75 parts deionized water by weight.

[0074] The ceramide NP is nanoliposome-wrapped ceramide NP, and the preparation method of the nanoliposome-wrapped ceramide NP comprises the following steps:

[0075] A1, after adding ceramide NP, lecithin and cholesterol into a container, add anhydrous ethanol, stir in a 50 DEG C water bath until completely dissolved, remove the organic solvent by rotary evaporation, to obtain a lipid film;

[0076] A2, pour the preheated PBS buffer solution to 50 DEG C into the lipid film, hydrate in a 50 DEG C water bath to obtain a liposome suspension;

[0077] A3, the liposome suspension is placed in an ice water bath, ultrasonic treatment, high pressure homogenization, filtration, to obtain nanoliposome-wrapped ceramide NP.

[0078] The mass ratio of ceramide NP, lecithin, cholesterol and anhydrous ethanol in step A1 is 1:15:4:20.

[0079] The mass ratio of the lipid film and the PBS buffer solution in step A2 is 1:3;The pH of the PBS buffer solution is 7.4;The hydration refers to stirring at a speed of 200 rpm for 2.5 h.

[0080] The ultrasonic power of the ultrasonic treatment in step A3 is 400 W, and the ultrasonic time is 10 min;The high pressure homogenization refers to controlling the interval of 0.3 min before and after each homogenization cycle, first homogenizing at 800 bar for 3 times, each time for 2.5 min, and then homogenizing at 1200 bar for 5 times, each time for 1 min;The filtration uses 0.22 μm filter membrane.

[0081] The preparation method of the Dendrobium officinale-Tremella fuciformis-glucan complex comprises the following steps:

[0082] B1, mix the dendrobium officinale powder and deionized water, adjust the pH to 4.5 by using citric acid, then add cellulase, and carry out enzymatic hydrolysis at 50℃ for 2.5h, after inactivation by increasing the temperature, continue to extract at 50℃ for 2.5h, separate and collect the extract, concentrate under reduced pressure to 1 / 5 of the original volume, obtain concentrated extract, then stir and add anhydrous ethanol, stand at 4℃ for 12h, centrifugal collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and then vacuum dry at 50℃ to obtain dendrobium officinale polysaccharide powder;

[0083] B2, mix the tremella fuciformis powder and deionized water, then reflux extract at 95℃ for 3.5h, separate and collect the filtrate, repeat the extraction once, then combine the two filtrates and concentrate under reduced pressure to 1 / 5 of the original volume to obtain concentrated filtrate, then stir and add anhydrous ethanol, stand at 4℃ for 12h, centrifugal collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and then vacuum dry at 50℃ to obtain tremella fuciformis polysaccharide powder;

[0084] B3, mix the dendrobium officinale polysaccharide powder, tremella fuciformis polysaccharide powder, beta-glucan powder and deionized water, then stir at low speed until a uniform colloidal solution is formed, stand at 15℃ for 12h, and then freeze dry to obtain dendrobium officinale-tremella fuciformis-glucan complex.

[0085] The mass ratio of the dendrobium officinale powder, deionized water and cellulase in step B1 is 1:30:0.005; the volume ratio of the concentrated extract and anhydrous ethanol is 1:4.

[0086] The mass ratio of the tremella fuciformis powder and deionized water in step B2 is 1:50; the volume ratio of the concentrated filtrate and anhydrous ethanol is 1:3.

[0087] The mass ratio of the dendrobium officinale polysaccharide powder, tremella fuciformis polysaccharide powder, beta-glucan powder and deionized water in step B3 is 5:8:2:300; the low speed stirring refers to stirring at a speed of 100rpm at room temperature.

[0088] The preparation method of the light and thin moisturizing lip cream comprises the following steps:

[0089] C1, mix white pool seed oil, ceramide NP, lecithin and caprylic / capric triglyceride, stir uniformly in water bath at 76℃, and keep for 11min to obtain a first mixture;

[0090] C2, mix the dendrobium officinale-tremella fuciformis-glucan complex, tetrahydro methyl pyrimidine carboxylic acid, 1,3-propanediol and deionized water, stir uniformly in water bath at 76℃, and keep for 11min to obtain a second mixture;

[0091] C3, under the stirring speed of 400rpm, add the first mixture to the second mixture, then stir at a speed of 2500rpm for 3min to obtain a primary emulsion;

[0092] C4, when the initial emulsion is stirred to 35 DEG C in an ice water bath, inulin, cooling agent WS-23 is added, when the stirring temperature is lowered to 30 DEG C, vitamin E, octanoyl hydroxamic acid, ethylhexylglycerin is added, the stirring speed is lowered to 200 rpm, the pH is adjusted to 5.3 and stirred uniformly, vacuum degassing, filling, to obtain a light and thin moisturizing lip cream.

[0093] Example 4

[0094] A light and thin moisturizing lip cream, the raw materials of which comprise, by weight parts, 4.3 parts of white pool seed oil, 1.1 parts of ceramide NP, 1.55 parts of lecithin, 3.3 parts of caprylic / capric acid triglyceride, 10.2 parts of Dendrobium officinale- Tremella fuciformis-glucan complex, 1.1 parts of tetrahydro methyl pyrimidine carboxylic acid, 5.3 parts of 1,3-propanediol, 0.55 parts of inulin, 0.11 parts of cooling agent WS-23, 0.22 parts of vitamin E, 0.08 parts of octanoyl hydroxamic acid, 0.45 parts of ethylhexylglycerin, 75.5 parts of deionized water.

[0095] The ceramide NP is a nano-liposome-encapsulated ceramide NP, and the preparation method of the nano-liposome-encapsulated ceramide NP comprises the following steps:

[0096] A1, ceramide NP, lecithin, cholesterol are added into a container, then anhydrous ethanol is added, stirring in a 52 DEG C water bath until completely dissolved, removing the organic solvent by rotary evaporation to obtain a lipid film;

[0097] A2, pour the preheated PBS buffer solution to 52 DEG C into the lipid film, hydrate in a 52 DEG C water bath to obtain a liposome suspension;

[0098] A3, the liposome suspension is placed in an ice water bath, ultrasonic treatment, high pressure homogenization, filtration to obtain a nano-liposome-encapsulated ceramide NP.

[0099] The mass ratio of ceramide NP, lecithin, cholesterol, anhydrous ethanol in step A1 is 1:16:4.5:20.3.

[0100] The mass ratio of the lipid film and the PBS buffer solution in step A2 is 1:3.2; the pH of the PBS buffer solution is 7.5; the hydration refers to stirring at a stirring speed of 250 rpm for 2.8 h.

[0101] The ultrasonic power of the ultrasonic treatment in step A3 is 500 W, and the ultrasonic time is 11 min; the high-pressure homogenization refers to controlling the interval of 0.4 min before and after each homogenization cycle, homogenizing at 850 bar for 3 times, each time for 3 min, and then homogenizing at 1250 bar for 5 times, each time for 1.5 min; the filtration uses a 0.22 μm filter membrane.

[0102] The preparation method of the Dendrobium officinale-Tremella fuciformis-glucan complex comprises the following steps:

[0103] B1, mix the Dendrobium officinale powder and deionized water, adjust the pH to 4.6 using citric acid, then add cellulase, and enzymatically hydrolyze at 51°C for 2.7 h; after inactivation by heating, continue to extract at 51°C for 2.7 h; separate and collect the extract, concentrate under reduced pressure to 1 / 5 of the original volume, obtain the concentrated extract, then stir and add anhydrous ethanol, and stand at 4°C for 13 h; centrifugally collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and then vacuum dry at 50°C to obtain the Dendrobium officinale polysaccharide powder;

[0104] B2, mix the Tremella fuciformis powder and deionized water, and reflux extract at 96°C for 3.6 h; after repeating the extraction once, combine the two obtained filtrates and concentrate under reduced pressure to 1 / 5 of the original volume to obtain the concentrated filtrate; then stir and add anhydrous ethanol, and stand at 4°C for 13 h; centrifugally collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and then vacuum dry at 50°C to obtain the Tremella fuciformis polysaccharide powder;

[0105] B3, mix the Dendrobium officinale polysaccharide powder, the Tremella fuciformis polysaccharide powder, the β-glucan powder, and deionized water, and low-speed stir to form a uniform colloidal solution; stand at 16°C for 13 h, and then freeze-dry to obtain the Dendrobium officinale-Tremella fuciformis-glucan complex.

[0106] The mass ratio of the Dendrobium officinale powder, deionized water, and cellulase in step B1 is 1:31:0.006; the volume ratio of the concentrated extract and anhydrous ethanol is 1:4.5.

[0107] The mass ratio of the Tremella fuciformis powder and deionized water in step B2 is 1:51; the volume ratio of the concentrated filtrate and anhydrous ethanol is 1:3.5.

[0108] The mass ratio of the Dendrobium officinale polysaccharide powder, the Tremella fuciformis polysaccharide powder, the β-glucan powder, and deionized water in step B3 is 5.2:8.3:2.2:304; the low-speed stirring refers to stirring at a speed of 120 rpm at room temperature.

[0109] The preparation method of the light and thin moisturizing lip cream comprises the following steps:

[0110] C1, mix white pool flower seed oil, ceramide NP, lecithin, caprylic acid / capric acid triglyceride, stir evenly under water bath at 76℃, and keep for 11 min, to obtain a first mixture;

[0111] C2, mix dendrobium officinale- tremella fuciformis-glucan complex, tetrahydro methyl pyrimidine carboxylic acid, 1,3-propanediol, deionized water, stir evenly under water bath at 76℃, and keep for 11 min, to obtain a second mixture;

[0112] C3, under the stirring speed of 450 rpm, add the first mixture to the second mixture, stir at the speed of 2800 rpm for 3.5 min, to obtain a primary emulsion;

[0113] C4, under the stirring speed of 450 rpm, place the primary emulsion in an ice water bath, stir and cool to 36℃, add inulin and cooling agent WS-23, stir and cool to 31℃, add in vitamin E, octanoyl hydroxamic acid and ethylhexyl glycerin, reduce the stirring speed to 220 rpm, adjust the pH to 5.4 and stir evenly, vacuum defoam, fill, to obtain a light and thin moisturizing lip cream.

[0114] Example 5

[0115] A light and thin moisturizing lip cream, the raw materials of which comprise, by weight parts, 4.4 parts of white pool flower seed oil, 1.2 parts of ceramide NP, 1.6 parts of lecithin, 3.5 parts of caprylic acid / capric acid triglyceride, 10.5 parts of dendrobium officinale-tremella fuciformis-glucan complex, 1.2 parts of tetrahydro methyl pyrimidine carboxylic acid, 5.5 parts of 1,3-propanediol, 0.6 parts of inulin, 0.12 parts of cooling agent WS-23, 0.25 parts of vitamin E, 0.1 parts of octanoyl hydroxamic acid, 0.5 parts of ethylhexyl glycerin, and 76 parts of deionized water.

[0116] The ceramide NP is a nano-liposome-encapsulated ceramide NP, and the preparation method of the nano-liposome-encapsulated ceramide NP comprises the following steps:

[0117] A1, add ceramide NP, lecithin and cholesterol into a container, then add anhydrous ethanol, stir in a 52℃ water bath until completely dissolved, remove the organic solvent by rotary evaporation, to obtain a lipid film;

[0118] A2, pour the preheated PBS buffer solution to the lipid film, hydrate in a 52℃ water bath, to obtain a liposome suspension;

[0119] A3, place the liposome suspension in an ice water bath, ultrasonic treatment, high-pressure homogenization, filtration, to obtain a nano-liposome-encapsulated ceramide NP.

[0120] The mass ratio of the ceramide NP, lecithin, cholesterol, and anhydrous ethanol in step A1 is 1:16.5:5:20.5.

[0121] The mass ratio of the lipid film and the PBS buffer in step A2 is 1:3.5; the pH of the PBS buffer is 7.5; the hydration refers to stirring for 3 h at a speed of 250 rpm.

[0122] The ultrasonic power of the ultrasonic treatment in step A3 is 500 W, and the ultrasonic time is 12 min; the high-pressure homogenization refers to controlling the interval of 0.4 min before and after each homogenization cycle, homogenizing at 850 bar for 3 min each time, and then homogenizing at 1250 bar for 5 times, 1.5 min each time; the filtration uses a 0.22 μm filter membrane.

[0123] The preparation method of the Dendrobium officinale-Tremella fuciformis-glucan complex comprises the following steps:

[0124] B1, mix the Dendrobium officinale powder and deionized water, adjust the pH to 4.6 using citric acid, then add cellulase, and enzymatically hydrolyze at 52°C for 3 h; after inactivation by increasing the temperature, continue to extract at 52°C for 3 h; separate and collect the extract, concentrate under reduced pressure to 1 / 5 of the original volume, obtain concentrated extract, then stir and add anhydrous ethanol, and stand at 4°C for 14 h; centrifugally collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and then vacuum dry at 50°C to obtain Dendrobium officinale polysaccharide powder;

[0125] B2, mix the Tremella fuciformis powder and deionized water, and reflux extract at 96°C for 4 h; separate and collect the filtrate, repeat the extraction once, combine the two obtained filtrates, and concentrate under reduced pressure to 1 / 5 of the original volume to obtain concentrated filtrate; then stir and add anhydrous ethanol, and stand at 4°C for 14 h; centrifugally collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and then vacuum dry at 50°C to obtain Tremella fuciformis polysaccharide powder;

[0126] B3, mix the Dendrobium officinale polysaccharide powder, Tremella fuciformis polysaccharide powder, and β-glucan powder with deionized water, and stir at low speed until a uniform colloidal solution is formed; stand at 16°C for 14 h, and then freeze-dry to obtain the Dendrobium officinale-Tremella fuciformis-glucan complex.

[0127] The mass ratio of the Dendrobium officinale powder, deionized water, and cellulase in step B1 is 1:32:0.006; the volume ratio of the concentrated extract and anhydrous ethanol is 1:4.5.

[0128] The mass ratio of the Tremella fuciformis powder and deionized water in step B2 is 1:52; the volume ratio of the concentrated filtrate and anhydrous ethanol is 1:3.5.

[0129] The mass ratio of the Dendrobium polysaccharide powder, the Tremella polysaccharide powder, the beta-glucan powder, and the deionized water in step B3 is 5.5:8.5:2.5:310; the low-speed stirring refers to stirring at a speed of 120 rpm at room temperature.

[0130] The preparation method of the light and thin moisturizing lip cream comprises the following steps:

[0131] C1, mix the white pool seed oil, the ceramide NP, the lecithin, and the caprylic / capric acid triglyceride, stir uniformly in a water bath at 77 DEG C, and keep for 12 min to obtain a first mixture;

[0132] C2, mix the Dendrobium-Tremella-glucan complex, the tetrahydro methyl pyrimidine carboxylic acid, the 1,3-propanediol, and the deionized water, stir uniformly in a water bath at 77 DEG C, and keep for 12 min to obtain a second mixture;

[0133] C3, under the stirring speed of 450 rpm, add the first mixture to the second mixture, stir at a speed of 2800 rpm for 4 min to obtain a primary emulsion;

[0134] C4, under the stirring speed of 450 rpm, place the primary emulsion in an ice water bath and stir to cool to 37 DEG C, then add the inulin and the cooling agent WS-23, stir to cool to 32 DEG C, then add the vitamin E, the octanoyl hydroxamic acid, and the ethylhexyl glycerin, reduce the stirring speed to 220 rpm, adjust the pH to 5.5 and stir uniformly, vacuum degassing, and filling to obtain the light and thin moisturizing lip cream.

[0135] Comparative Example 1

[0136] On the basis of Example 3, the ceramide NP is not nano-liposome wrapped, and other conditions remain unchanged.

[0137] Comparative Example 2

[0138] On the basis of Example 3, other conditions remain unchanged, and the mass ratio of the lipid film in step A2 and the PBS buffer is changed to 1:1.

[0139] Comparative Example 3

[0140] On the basis of Example 3, other conditions remain unchanged, and the parameters of high-pressure homogenization are changed to homogenization at 800 bar for 7.5 min and then homogenization at 1200 bar for 5 min, and other conditions remain unchanged.

[0141] Comparative Example 4

[0142] On the basis of Example 3, the Dendrobium candidum-Tremella fuciformis-glucan complex was removed, and an equal weight of hyaluronic acid (purchased from Hebei Jiuxing Chemical Product Co., Ltd., CAS No. 9067-32-7) was used instead, and the other conditions remained the same as in Example 3.

[0143] Comparative Example 5

[0144] On the basis of Example 3, the inulin was removed, and an equal weight of a-glucan oligosaccharide (purchased from Hubei Langbowan Biomedicine Co., Ltd., CAS No. 27707-45-5) was used instead, and the other conditions remained the same as in Example 3.

[0145] Comparative Example 6

[0146] On the basis of Example 3, the Dendrobium candidum-Tremella fuciformis-glucan complex was removed, and a mixture of Dendrobium candidum polysaccharide powder, Tremella fuciformis polysaccharide powder and β-glucan powder mixed in a mass ratio of 5:8:2 was used instead, wherein the Dendrobium candidum polysaccharide powder and the Tremella fuciformis polysaccharide powder were both purchased from Lanzhou Waterless Biological Technology Co., Ltd., and the other conditions remained the same as in Example 3.

[0147] Comparative Example 7

[0148] On the basis of Example 3, the Dendrobium candidum-Tremella fuciformis-glucan complex was removed, and an equal weight of Dendrobium candidum-glucan complex was used instead, and the other conditions remained the same as in Example 3, and the preparation method of the Dendrobium candidum-glucan complex comprised the following steps:

[0149] B1, the Dendrobium candidum powder and deionized water were mixed, citric acid was used to adjust the pH to 4.5, and then cellulase was added, and the enzyme was hydrolyzed at 50°C for 2.5h, after inactivation by heating, the temperature was lowered to 50°C for further extraction for 2.5h, the extract was separated and collected, and concentrated under reduced pressure to 1 / 5 of the original volume, to obtain a concentrated extract, and then anhydrous ethanol was added by stirring, and placed at 4°C for 12h, and then centrifuged to collect the precipitate, which was washed with anhydrous ethanol and acetone, and then dried at 50°C under vacuum to obtain Dendrobium candidum polysaccharide powder;

[0150] B2, the Dendrobium candidum polysaccharide powder, β-glucan powder and deionized water were mixed in a mass ratio of 13:2:300, and then stirred at low speed until a uniform colloidal solution was formed, and then placed at 15°C for 12h, and then freeze-dried to obtain the Dendrobium candidum-glucan complex.

[0151] Comparative Example 8

[0152] On the basis of Example 3, the Dendrobium candidum-Tremella fuciformis-glucan complex was removed, and an equal weight of Tremella fuciformis-glucan complex was used instead, and the other conditions remained the same as in Example 3, and the preparation method of the Tremella fuciformis-glucan complex comprised the following steps:

[0153] B1, the tremella powder and deionized water were mixed, and then refluxed at 95°C for 3.5h, the filtrate was collected, and the two filtrates were combined after one more extraction and concentrated under reduced pressure to 1 / 5 of the original volume to obtain a concentrated filtrate, then anhydrous ethanol was added with stirring, and the mixture was placed at 4°C for 12h, the precipitate was collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50°C under vacuum to obtain tremella polysaccharide powder;

[0154] B3, the tremella polysaccharide powder, β-glucan powder and deionized water were mixed at a mass ratio of 13:2:300, and then stirred at low speed until a uniform colloidal solution was formed, the mixture was placed at 15°C for 12h, and then freeze-dried to obtain the dendrobium officinale-tremella-glucan complex.

[0155] Comparative Example 9

[0156] Based on Example 3, other conditions were kept unchanged, and the dendrobium officinale-tremella-glucan complex was removed, and an equal amount of dendrobium officinale-tremella complex was used to replace it, the preparation method of the dendrobium officinale-tremella complex comprising the following steps:

[0157] B1, the dendrobium officinale powder and deionized water were mixed, and then citric acid was added to adjust the pH to 4.5, and then cellulase was added for enzymatic hydrolysis at 50°C for 2.5h, after inactivation by heating, the temperature was lowered to 50°C for another 2.5h of extraction, the extract was collected, concentrated under reduced pressure to 1 / 5 of the original volume to obtain a concentrated extract, then anhydrous ethanol was added with stirring, and the mixture was placed at 4°C for 12h, the precipitate was collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50°C under vacuum to obtain dendrobium officinale polysaccharide powder;

[0158] B2, the tremella powder and deionized water were mixed, and then refluxed at 95°C for 3.5h, the filtrate was collected, and the two filtrates were combined after one more extraction and concentrated under reduced pressure to 1 / 5 of the original volume to obtain a concentrated filtrate, then anhydrous ethanol was added with stirring, and the mixture was placed at 4°C for 12h, the precipitate was collected by centrifugation, washed with anhydrous ethanol and acetone, and then dried at 50°C under vacuum to obtain tremella polysaccharide powder;

[0159] B3, the dendrobium officinale polysaccharide powder, tremella polysaccharide powder and deionized water were mixed at a mass ratio of 6:9:300, and then stirred at low speed until a uniform colloidal solution was formed, the mixture was placed at 15°C for 12h, and then freeze-dried to obtain the dendrobium officinale-tremella-glucan complex.

[0160] Comparative Example 10

[0161] Based on Example 3, other conditions were kept unchanged, and the mass ratio of the dendrobium officinale polysaccharide powder, tremella polysaccharide powder, β-glucan powder and deionized water was changed to 8:6:1:300, and other conditions were kept unchanged.

[0162] Comparative Example 11

[0163] On the basis of Example 3, the preparation method of the light and thin moisturizing lip balm was changed to include the following steps without changing other conditions:

[0164] C1, mix white pool flower seed oil, ceramide NP, lecithin, caprylic acid / capric acid triglyceride, stir uniformly under water bath at 76℃, and keep for 11 min to obtain a first mixture;

[0165] C2, mix dendrobium officinale- tremella fuciformis-glucan complex, tetrahydro methyl pyrimidine carboxylic acid, 1,3-propanediol, deionized water, stir uniformly under water bath at 76℃, and keep for 11 min to obtain a second mixture;

[0166] C3, under the stirring speed of 400 rpm, add the first mixture to the second mixture, and stir at the speed of 2500 rpm for 3 min to obtain a primary emulsion;

[0167] C4, under the stirring speed of 400 rpm, place the primary emulsion in an ice water bath to stir and cool to 35℃, add inulin, cooling agent WS-23, vitamin E, capryl hydroxamic acid, and ethylhexyl glycerin, adjust the pH to 5.3 and stir uniformly, vacuum defoam, fill, and obtain the light and thin moisturizing lip balm.

[0168] Comparative Example 12

[0169] The preparation method of the light and thin moisturizing lip balm includes the following steps:

[0170] C1, mix white pool flower seed oil, ceramide NP, lecithin, caprylic acid / capric acid triglyceride, stir uniformly under water bath at 76℃, and keep for 11 min to obtain a first mixture;

[0171] C2, mix dendrobium officinale- tremella fuciformis-glucan complex, tetrahydro methyl pyrimidine carboxylic acid, 1,3-propanediol, deionized water, stir uniformly under water bath at 76℃, and keep for 11 min to obtain a second mixture;

[0172] C3, under the stirring speed of 400 rpm, add the first mixture to the second mixture, and stir at the speed of 2500 rpm for 3 min to obtain a primary emulsion;

[0173] C4, under the stirring speed of 400 rpm, place the primary emulsion in an ice water bath to stir and cool to 30℃, add inulin, cooling agent WS-23, vitamin E, capryl hydroxamic acid, and ethylhexyl glycerin, adjust the pH to 5.3 and stir uniformly, vacuum defoam, fill, and obtain the light and thin moisturizing lip balm.

[0174] 1. Skin irritation test

[0175] The lip cream prepared in Examples 1-5 was used as a sample, 30 volunteers aged 18-50 years were selected and randomly divided into 5 groups, and the volunteers participating in the test met the specified standards. A skin closed patch test was performed, qualified patch test materials with an area of not more than 40 mm 2 , and a depth of about 1 mm were selected, 0.02±0.005 mL of the test product was taken in the patch test material, and the low sensitization adhesive tape was attached to the flexor of the forearm of the test subject, and the patch test material was removed after 24 hours. The skin reaction was observed at 0.5 h, 2 h and 24 h after removal, respectively, and the evaluation results were divided into 0-4 levels, wherein 0 level was negative reaction, and the specific results are shown in Table 1.

[0176] Table 1 Skin irritation test results

[0177]

[0178] As shown in Table 1, the light and thin moisturizing lip cream prepared by the present application does not have adverse reactions when used, and the ingredients are mild and non-irritating.

[0179] 2. Moisturizing test

[0180] 85 volunteers aged 18-50 years were selected and randomly divided into 17 groups, and the volunteers participating in the test met the specified standards. The lip cream prepared in Examples 1-5 and Comparative Examples 1-12 was used as a sample, and the flexor position of the forearm was selected as the measurement area of 2 cm x 2 cm. 8 μL of the sample was applied to the measurement area, and the sample was absorbed by lightly patting with a finger cover. A water content meter corneometer was used to measure before use, 0 h, 2 h, 4 h and 8 h, respectively. Five times were measured at the same point, and the average value of three times was taken after excluding the maximum value and the minimum value, and was recorded as shown in Table 2.

[0181] Table 2 Moisturizing test results

[0182]

[0183] As shown in Table 2, the light and thin moisturizing lip cream prepared by the present application has good moisturizing effect.

[0184] 3. Lip line lightening effect test

[0185] 85 volunteers aged 18-50 years were selected and randomly divided into 17 groups, and the volunteers participating in the test met the specified standards. The lip cream prepared in Examples 1-5 and Comparative Examples 1-12 was used as a sample, and the sample was used once in the morning and evening. The lip line depth (μm) was tested by using a MicroSkin II multifunctional skin mirror image analysis system before use and after 1 month of use. Before each test, the lips and surrounding skin were cleaned with water and balanced in the test environment for 30 min. The test results are shown in Table 3.

[0186] Table 3 Lip line lightening effect test results

[0187]

[0188] As shown in Table 3, the light and thin moisturizing lip cream prepared by the present application can effectively adjust the lip condition and improve the lip line depth.

[0189] 4. Sensory evaluation

[0190] 85 volunteers aged 18-50 years old were selected and randomly divided into 17 groups. The volunteers participating in the test all met the specified standards. The lip creams prepared by Examples 1-5 and Comparative Examples 1-12 were used as test samples, and the moisturizing degree, spreading degree and refreshing degree of the test samples were evaluated. The scores were 1-10 points. The higher the score, the better the moisturizing degree, spreading degree and refreshing degree. After scoring, the average score of each group of test sample volunteers was taken and recorded as shown in Table 4.

[0191] Table 4 Sensory evaluation results

[0192]

[0193] As shown in Table 4, the light and thin moisturizing lip cream prepared by the present application has good skin feel, easy spreading and refreshing without stickiness when used.

[0194] The above is only a preferred embodiment of the present application, and does not limit the present application in any form. Although the present application has been disclosed as above with a preferred embodiment, it is not intended to limit the present application. Any person skilled in the art can make some changes or modifications to the above disclosed technical content without departing from the scope of the present application, and any indirect modification, equivalent change and modification of the above embodiment according to the technical essence of the present application still belong to the scope of the present application.

Claims

1. A lightweight, moisturizing lip balm, characterized in that: The ingredients of the lightweight and moisturizing lip cream, by weight, include 4-4.4 parts meadowfoam seed oil, 0.8-1.2 parts ceramide NP, 1.4-1.6 parts lecithin, 2.5-3.5 parts caprylic / capric triglycerides, 9.5-10.5 parts Dendrobium officinale-Tremella fuciformis-glucan complex, 0.8-1.2 parts tetrahydromethylpyrimidine carboxylic acid, 4.5-5.5 parts 1,3-propanediol, 0.4-0.6 parts inulin, 0.08-0.12 parts cooling agent WS-23, 0.15-0.25 parts vitamin E, 0.04-0.1 parts capryloyl hydroxamic acid, 0.3-0.5 parts ethylhexylglycerin, and 74-76 parts deionized water.

2. The lightweight, moisturizing lip balm according to claim 1, characterized in that: The ceramide NP is a ceramide NP encapsulated in nanoliposomes, and the preparation method of the ceramide NP encapsulated in nanoliposomes includes the following steps: A1. Add ceramide NP, lecithin, and cholesterol to a container, then add anhydrous ethanol, stir in a water bath at 48-52℃ until completely dissolved, remove the organic solvent by rotary evaporation, and obtain a lipid film. A2. Pour PBS buffer preheated to 48-52℃ into the lipid membrane and hydrate it in a water bath at 48-52℃ to obtain a liposome suspension. A3. The liposome suspension was placed in an ice-water bath, sonicated, homogenized under high pressure, and filtered to obtain ceramide NP encapsulated in nanoliposomes.

3. The lightweight, moisturizing lip balm according to claim 2, characterized in that: The mass ratio of ceramide NP, lecithin, cholesterol, and anhydrous ethanol in step A1 is 1:13.5-16.5:3-5:19.5-20.

5.

4. The lightweight, moisturizing lip balm according to claim 2, characterized in that: The mass ratio of the lipid membrane and PBS buffer in step A2 is 1:2.5-3.5; the pH of the PBS buffer is 7.3-7.5; the hydration refers to stirring at 150-250 rpm for 2-3 hours.

5. A lightweight, moisturizing lip balm according to claim 2, characterized in that: The ultrasonic power of the ultrasonic treatment in step A3 is 300-500W, and the ultrasonic time is 8-12min; the high-pressure homogenization refers to controlling the interval between each homogenization cycle to be 0.2-0.4min, first homogenizing 3 times at 750-850bar, each time for 2-3min, and then homogenizing 5 times at 1150-1250bar, each time for 0.5-1.5min; the filtration uses a 0.22μm filter membrane.

6. The lightweight, moisturizing lip balm according to claim 1, characterized in that: The preparation method of the Dendrobium officinale-Tremella fuciformis-dextran complex includes the following steps: B1. Mix Dendrobium officinale powder and deionized water, adjust the pH to 4.4-4.6 with citric acid, add cellulase, and enzymatically hydrolyze at 48-52℃ for 2-3 hours. After inactivation by heating, cool to 48-52℃ and continue extraction for 2-3 hours. Separate and collect the extract, concentrate under reduced pressure to 1 / 5 of the original volume to obtain concentrated extract, stir and add anhydrous ethanol, let stand at 4℃ for 10-14 hours, centrifuge to collect the precipitate, wash and dehydrate with anhydrous ethanol and acetone, and vacuum dry at 50℃ to obtain Dendrobium officinale polysaccharide powder. B2. Mix the tremella powder and deionized water and reflux at 94-96℃ for 3-4 hours. Separate and collect the filtrate. Repeat the extraction once and combine the two filtrates. Concentrate under reduced pressure to 1 / 5 of the original volume to obtain concentrated filtrate. Stir and add anhydrous ethanol. Let stand at 4℃ for 10-14 hours. Centrifuge to collect the precipitate. Wash and dehydrate with anhydrous ethanol and acetone. Dry under vacuum at 50℃ to obtain tremella polysaccharide powder. B3. Mix Dendrobium officinale polysaccharide powder, Tremella fuciformis polysaccharide powder, β-glucan powder and deionized water, stir at low speed until a uniform colloidal solution is formed, let stand at 14-16℃ for 10-14 hours, freeze dry to obtain Dendrobium officinale-Tremella fuciformis-glucan complex.

7. A lightweight, moisturizing lip balm according to claim 6, characterized in that: The mass ratio of Dendrobium officinale powder, deionized water, and cellulase in step B1 is 1:28-32:0.004-0.006; the volume ratio of the concentrated extract to anhydrous ethanol is 1:3.5-4.

5.

8. A lightweight, moisturizing lip balm according to claim 6, characterized in that: In step B2, the mass ratio of the tremella powder to deionized water is 1:48-52; and the volume ratio of the concentrated filtrate to anhydrous ethanol is 1:2.5-3.

5.

9. A lightweight, moisturizing lip balm according to claim 6, characterized in that: The mass ratio of Dendrobium officinale polysaccharide powder, Tremella fuciformis polysaccharide powder, β-glucan powder, and deionized water in step B3 is 4.5-5.5:7.5-8.5:1.5-2.5:290-310; the low-speed stirring refers to stirring at 80-120 rpm at room temperature.

10. A method for preparing a lightweight, moisturizing lip cream as described in any one of claims 1-9, characterized in that: The preparation method of the lightweight and moisturizing lip balm includes the following steps: C1. Mix meadowfoam seed oil, ceramide NP, lecithin, and caprylic / capric triglycerides, stir evenly in a water bath at 73-77℃, and keep warm for 8-12 minutes to obtain the first mixture; C2. Mix Dendrobium officinale-Tremella fuciformis-dextran complex, tetrahydromethylpyrimidine carboxylic acid, 1,3-propanediol and deionized water, stir evenly in a water bath at 73-77℃, and keep warm for 8-12 minutes to obtain the second mixture; C3. After adding the first mixture to the second mixture at a stirring speed of 350-450 rpm, stir at a speed of 2200-2800 rpm for 2-4 minutes to obtain the primary emulsion. C4. While stirring at 350-450 rpm, place the primary emulsion in an ice-water bath and stir to cool it to 33-37℃. Add inulin and cooling agent WS-23, and stir to cool it to 28-32℃. Add vitamin E, capryloyl hydroxamic acid, and ethylhexylglycerin, while reducing the stirring speed to 180-220 rpm. Adjust the pH to 5.1-5.5 and stir evenly. Vacuum degassing and filling are then performed to obtain a light and moisturizing lip balm.

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