A drug delivery device based on the brain extracellular space approach

By using a flexible drug delivery probe and a closed-loop control system, the drug delivery rate and location can be adjusted in real time, solving the problems of brain tissue damage and uneven drug distribution in elderly patients, and achieving efficient and safe drug delivery.

CN121177608BActive Publication Date: 2026-05-15BEIJING REHABILITATION HOSPITAL CAPITAL MEDICAL UNIVERSITY(BEIJING WORKERS SANATORIUM)
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Patent Information

Application Number
CN202511729985.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-11-24
Publication Date
2026-05-15
Estimated Expiration
2045-11-24

AI Technical Summary

Technical Problem

Existing drug delivery devices have fixed parameters in the brain tissue of elderly patients and rely on manual operation, resulting in a high risk of tissue damage, poor controllability of drug distribution, and an inability to adapt to the microscopic fragility and rapid changes of the elderly brain.

Method used

Employing a flexible drug delivery probe, a MEMS piezoresistive pressure sensor array, and a closed-loop controller, combined with a piezoelectric ceramic-driven micropump and an optical positioning module, it achieves real-time pressure detection and automatic drug delivery rate adjustment. It integrates a sterile sealed shell and radio frequency positioning markers to adapt to the biomechanical characteristics of the aging brain.

Benefits of technology

It significantly reduces physical stimulation of the vulnerable interstitial structures of the brain in the elderly, ensures controllable and safe drug distribution, reduces operational delays and misjudgments, and improves treatment efficiency and safety.

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Abstract

The application discloses a drug delivery device based on brain extracellular space pathway, and relates to the technical field of medical devices.The deformable characteristic of the flexible silicone probe reduces the puncture resistance, and in cooperation with the hydrophilic coating, the physical stimulation to the fragile gap structure of the old brain is significantly reduced.The device automatically adjusts the drug delivery behavior through real-time sensing and closed-loop control when encountering tissue pressure fluctuation, thereby avoiding local edema or microscopic tearing caused by traditional rigid probes.A pressure rate mapping model is designed based on the biomechanical characteristics of the old brain, so that the device can autonomously respond to changes in the gap environment and automatically reduce the speed when the pressure exceeds the threshold value, without the need for manual intervention by the doctor based on experience, thereby reducing abnormal drug distribution caused by operation delay or misjudgment.The mechanism is particularly suitable for the dynamic instability of the old brain ECS, and ensures that the parameters and physiological state are matched during the whole treatment.
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