Traditional Chinese medicine composition for treating intrauterine adhesion, enema and application

Abstract

The invention relates to the technical field of intrauterine adhesion treatment, and discloses a traditional Chinese medicine composition for treating intrauterine adhesion, an enema and application, and the traditional Chinese medicine composition is prepared from the following raw materials: sargentgloryvine stem, patrinia, honeysuckle stem, fructus forsythiae, vinegar-processed rhizoma sparganii, curcuma zedoary, cortex moutan, radix paeoniae rubra, spina gleditsiae, selfheal, beautiful sweetgum fruit, folium artemisiae argyi, oldenlandia diffusa, honeysuckle, coix seed and peach kernel. A pure traditional Chinese medicine formula is used for replacing large-dose estrogen for adjuvant therapy, so that hormone-related side effects (such as endocrine disorder, thrombus risk and the like) are avoided, adhesion and relapse are reduced through the overall conditioning effect of traditional Chinese medicines, and the clinical problems of'unstable curative effect and easiness in relapse 'in traditional therapy are solved; and a safer and long-acting choice is provided for intrauterine adhesion treatment.

Description

Technical Field

[0001] This invention belongs to the technical field of treating intrauterine adhesions, specifically relating to a traditional Chinese medicine composition, enema, and application for treating intrauterine adhesions. Background Technology

[0002] The endometrium is the soil in which the embryo grows in the mother's body. A high-quality embryo and a receptive endometrium are essential conditions for embryo implantation and maintaining a normal pregnancy. Intrauterine adhesions refer to damage to the endometrium leading to partial or complete blockage of the uterine cavity, adversely affecting embryo implantation and pregnancy maintenance, and reducing female fertility. The current standard treatment is hysteroscopic surgery followed by high-dose estrogen therapy, but about half of the patients do not respond well and there are potential risks associated with medication, even leading to recurrent adhesions and multiple surgeries. This is a pressing problem to be solved in clinical practice. For women suffering from intrauterine adhesions, exploring new, more effective, and widely applicable treatment methods, and developing traditional Chinese medicine treatments for infertility caused by intrauterine adhesions, is a significant and urgent social need. Summary of the Invention

[0003] In view of the above-mentioned technical problems in related technologies, the present invention provides a traditional Chinese medicine composition, enema, and application for treating intrauterine adhesions, which can solve the above problems.

[0004] To achieve the above-mentioned technical objectives, the technical solution of the present invention is implemented as follows: A traditional Chinese medicine composition for treating intrauterine adhesions comprises the following raw materials in parts by weight: 1-20 parts of *Sargentodoxa cuneata*, 5-50 parts of *Patrinia scabiosaefolia*, 5-40 parts of *Lonicera japonica*, 1-40 parts of *Forsythia suspensa*, 1-30 parts of *Sparganium stoloniferum* (processed with vinegar), 1-30 parts of *Curcuma zedoaria*, 5-20 parts of *Paeonia suffruticosa*, 5-35 parts of *Paeonia lactiflora*, 1-30 parts of *Gleditsia sinensis*, 5-30 parts of *Prunella vulgaris*, 5-50 parts of *Liquidambar formosana*, 1-40 parts of *Artemisia argyi*, 1-40 parts of *Hedyotis diffusa*, 1-30 parts of *Lonicera japonica*, 10-50 parts of *Coix lacryma-jobi*, and 5-20 parts of *Prunus persica*.

[0005] A traditional Chinese medicine composition for treating intrauterine adhesions comprises the following raw materials in parts by weight: 10-40 parts of *Sargentodoxa cuneata*, 10-40 parts of *Patrinia scabiosaefolia*, 10-40 parts of *Lonicera japonica*, 10-30 parts of *Forsythia suspensa*, 5-30 parts of *Sparganium stoloniferum* (processed with vinegar), 1-30 parts of *Curcuma zedoaria*, 1-30 parts of *Paeonia suffruticosa*, 1-40 parts of *Paeonia lactiflora*, 10-40 parts of *Gleditsia sinensis*, 10-40 parts of *Prunella vulgaris*, 10-40 parts of *Liquidambar formosana*, 1-30 parts of *Artemisia argyi*, 10-40 parts of *Hedyotis diffusa*, 1-30 parts of *Lonicera japonica*, 10-50 parts of *Coix lacryma-jobi*, and 1-10 parts of *Prunus persica*.

[0006] A traditional Chinese medicine enema for treating intrauterine adhesions, comprising the aforementioned traditional Chinese medicine composition for treating intrauterine adhesions.

[0007] Furthermore, the herbal enema is prepared by the following steps: First, weigh the herbal composition and soak it in a certain amount of water for 25-35 minutes; then decoct it twice, the first time for 0.5 hours and the second time for 0.3 hours; then combine the decoctions, let them stand for 1 hour, filter them, and take the filtered clear liquid; then, bring the filtered clear liquid to a boil over high heat, and then concentrate it to 100 ml over low heat; finally, boil the concentrated liquid again and dispense it.

[0008] The application of the aforementioned traditional Chinese medicine composition in the preparation of a drug for treating intrauterine adhesions.

[0009] The efficacy of the traditional Chinese medicine raw materials used in this invention is as follows: Large Blood Vine: Bitter, neutral. Enters the large intestine and liver meridians. Clears heat and detoxifies, invigorates blood, dispels wind and relieves pain.

[0010] Patrinia scabiosifolia: pungent, bitter, slightly cold. It enters the stomach, large intestine, and liver meridians. It clears heat and detoxifies, reduces swelling and drains pus, removes blood stasis and relieves pain.

[0011] Honeysuckle vine: sweet, cold. It enters the lung and stomach meridians. It clears heat and detoxifies, dispels wind and unblocks the meridians.

[0012] Forsythia: Bitter, slightly cold. It enters the lung, heart, and small intestine meridians. It clears heat and detoxifies, reduces swelling and dissipates nodules, and disperses wind-heat.

[0013] Vinegar-processed Sparganium: pungent, bitter, neutral. Enters the liver and spleen meridians. It breaks up blood stasis, promotes qi circulation, eliminates stagnation, and relieves pain.

[0014] Curcuma zedoaria: pungent, bitter, and warm. It enters the liver and spleen meridians. It breaks up blood stasis, promotes qi circulation, eliminates stagnation, and relieves pain.

[0015] Moutan bark: Bitter, pungent, slightly cold. It enters the heart, liver, and kidney meridians. It clears heat and cools the blood, invigorates blood circulation and removes blood stasis.

[0016] Red peony root: Bitter, slightly cold. Enters the liver meridian. Clears heat and cools the blood, disperses blood stasis and relieves pain.

[0017] Gleditsia sinensis thorns: pungent, warm. Enters the liver and stomach meridians. Reduces swelling and promotes detoxification, drains pus, and kills parasites.

[0018] Prunella vulgaris: pungent, bitter, and cold. It enters the liver and gallbladder meridians. It clears liver heat, improves eyesight, and reduces swelling.

[0019] Lu Lu Tong: Bitter, neutral. Enters the liver and kidney meridians. Dispels wind, invigorates blood circulation, promotes urination, and regulates menstruation.

[0020] Artemisia argyi: pungent, bitter, and warm in nature; slightly toxic. It enters the liver, spleen, and kidney meridians. It warms the meridians and stops bleeding, dispels cold and relieves pain; externally, it dispels dampness and relieves itching.

[0021] Oldenlandia diffusa: Slightly bitter and sweet, cold in nature. It enters the stomach, large intestine, and small intestine meridians. It clears heat and detoxifies, promotes diuresis and relieves strangury.

[0022] Honeysuckle: Sweet, cold. It enters the lung, heart, and stomach meridians. It clears heat and detoxifies, and disperses wind-heat.

[0023] Job's tears: sweet, bland, and cool in nature. It enters the spleen, stomach, and lung meridians. It promotes diuresis and eliminates dampness, strengthens the spleen and stops diarrhea, relieves numbness, drains pus, and detoxifies and dissipates nodules.

[0024] Peach kernel: bitter, sweet, neutral. It enters the heart, liver, and large intestine meridians. It invigorates blood circulation, removes blood stasis, moistens the intestines and promotes bowel movements, and relieves cough and asthma.

[0025] The beneficial effects of this invention are as follows: This invention uses a pure Chinese medicine formula to replace high-dose estrogen as an adjuvant therapy, which not only avoids hormone-related side effects (such as endocrine disorders, thrombosis risk, etc.), but also reduces the recurrence of adhesions through the overall conditioning effect of Chinese medicine. It solves the clinical problem of "unstable efficacy and easy recurrence" in traditional treatments, and provides a safer and more effective option for the treatment of intrauterine adhesions. Detailed Implementation

[0026] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art are within the scope of protection of the present invention.

[0027] This application discloses a traditional Chinese medicine composition for treating intrauterine adhesions, which is composed of the following raw materials in parts by weight: 1-20 parts of *Sargentodoxa cuneata*, 5-50 parts of *Patrinia scabiosaefolia*, 5-40 parts of *Lonicera japonica*, 1-40 parts of *Forsythia suspensa*, 1-30 parts of *Sparganium stoloniferum* (processed with vinegar), 1-30 parts of *Curcuma zedoaria*, 5-20 parts of *Paeonia suffruticosa*, 5-35 parts of *Paeonia lactiflora*, 1-30 parts of *Gleditsia sinensis*, 5-30 parts of *Prunella vulgaris*, 5-50 parts of *Liquidambar formosana*, 1-40 parts of *Artemisia argyi*, 1-40 parts of *Hedyotis diffusa*, 1-30 parts of *Lonicera japonica*, 10-50 parts of *Coix lacryma-jobi*, and 5-20 parts of *Prunus persica*.

[0028] It may be composed of the following raw materials in parts by weight: 10-40 parts of *Sargentodoxa cuneata*, 10-40 parts of *Patrinia scabiosaefolia*, 10-40 parts of *Lonicera japonica*, 10-30 parts of *Forsythia suspensa*, 5-30 parts of *Sparganium stoloniferum* (processed with vinegar), 1-30 parts of *Curcuma zedoaria*, 1-30 parts of *Paeonia suffruticosa*, 1-40 parts of *Paeonia lactiflora*, 10-40 parts of *Gleditsia sinensis*, 10-40 parts of *Prunella vulgaris*, 10-40 parts of *Liquidambar formosana*, 1-30 parts of *Artemisia argyi*, 10-40 parts of *Hedyotis diffusa*, 1-30 parts of *Lonicera japonica*, 10-50 parts of *Coix lacryma-jobi*, and 1-10 parts of *Prunus persica*.

[0029] This application relates to the use of a traditional Chinese medicine composition for treating intrauterine adhesions in the preparation of a drug for treating intrauterine adhesions. The traditional Chinese medicine composition can be prepared into a pharmaceutical preparation, which is an external preparation, and the dosage form of the pharmaceutical preparation is a decoction, powder, or granules.

[0030] In one specific embodiment, the drug preparation is used as a traditional Chinese medicine enema for treating intrauterine adhesions. The traditional Chinese medicine enema is prepared by the following steps: First, weigh the traditional Chinese medicine composition and soak it in a certain amount of water for 25-35 minutes; then decoct it twice, the first time for 0.5 hours and the second time for 0.3 hours; then combine the decoctions, let it stand for 1 hour, filter it, and take the filtered clear liquid; then, bring the filtered clear liquid to a boil over high heat, and then concentrate it to 100 ml over low heat; finally, boil the concentrated liquid again and dispense it.

[0031] Furthermore, when using this traditional Chinese medicine enema for treatment, the procedure is as follows: The enema formula is decocted, and 100ml of the liquid is drawn into a syringe. The temperature of the liquid is adjusted to 39-41℃. The infusion set is connected, and air is expelled. The needle of the infusion set is cut off, trimmed, and lubricated with paraffin oil. The patient lies on their right side with their buttocks elevated 10cm. The lubricated end of the infusion set is slowly inserted into the rectum 10-15cm through the anus, ensuring the liquid surface is no more than 30cm from the anus. Then, the regulating valve of the infusion set is slowly opened, allowing the medication to drip in at a rate of 60-70 drops / minute. After the medication is finished dripping, the infusion set is removed, and the anus is wiped clean. The medication should be kept in the body for at least one hour to ensure full absorption.

[0032] Furthermore, the following herbs were prepared: 15g of *Sargentodoxa cuneata*, 20g of *Patrinia scabiosaefolia*, 20g of *Lonicera japonica*, 15g of *Forsythia suspensa*, 10g of *Sparganium stoloniferum* (processed with vinegar), 10g of *Curcuma zedoaria*, 10g of *Paeonia suffruticosa*, 15g of *Paeonia lactiflora*, 15g of *Gleditsia sinensis* thorns, 15g of *Prunella vulgaris*, 20g of *Liquidambar formosana*, 10g of *Artemisia argyi*, 15g of *Hedyotis diffusa*, 10g of *Lonicera japonica*, 20g of *Coix lacryma-jobi*, and 8g of *Prunus persica*. Through the above preparation steps, a traditional Chinese medicine enema A was prepared. This enema was used on 42 infertile patients who met the diagnostic criteria for intrauterine adhesions and were scheduled for frozen embryo transfer. Clinical observation was conducted on patients using a randomized, blinded treatment protocol. The traditional Chinese medicine enema group (using the prepared traditional Chinese medicine enema A and treated using the above-described method) included 20 patients, while the control group included 22 patients (treated with hysteroscopic surgery). After 2-3 cycles of treatment, 80% of patients in the traditional Chinese medicine enema group showed significant improvement in endometrial thickness before transplantation compared to before surgery, while only 50% of patients in the control group showed improvement in endometrial thickness before transplantation.

[0033] In summary, the herbal composition of this invention is precisely formulated from 16 Chinese medicinal herbs, with each component having complementary effects, forming a synergistic effect of "clearing heat and detoxifying, promoting blood circulation and removing blood stasis, unblocking meridians and collaterals, and dispersing nodules and repairing tissues." It completely targets the pathological chain of intrauterine adhesions: "inflammatory damage - blood stasis obstruction - tissue adhesion - poor endometrial repair." Targeted anti-inflammatory treatment to eliminate the underlying cause of the lesion: The ingredients in the formula, such as Patrinia scabiosifolia, Lonicera japonica, Forsythia suspensa, Lonicera japonica, and Hedyotis diffusa, all have the effects of clearing heat and detoxifying, reducing swelling and dissipating nodules. They can effectively inhibit the local inflammatory response in the uterine cavity, reduce the continuous damage of inflammatory factors to the endometrium, and block the pathological link of adhesion aggravation from the source. Promoting blood circulation and removing blood stasis, and improving endometrial blood supply: Herbs such as vinegar-processed Sparganium, Curcuma zedoaria, peach kernel, red peony root, peony bark, and large-stem vine can break up blood stasis, promote qi circulation, relieve pain, improve local blood circulation in the uterine cavity, alleviate insufficient endometrial blood supply caused by blood stasis, and provide sufficient nutrition for endometrial regeneration. Unblocking the meridians and activating collaterals, loosening adhesions: Lulutong dispels wind and activates collaterals, unblocks the meridians, Gleditsia sinensis thorns reduce swelling and promote detoxification and dissipate nodules, and Prunella vulgaris clears the liver and dissipates nodules. The three can work together to loosen existing intrauterine adhesions and restore the normal shape of the uterine cavity. Strengthening the spleen and eliminating dampness, promoting endometrial repair: Coix seed promotes diuresis and eliminates dampness, detoxifies and dissipates nodules, while mugwort warms the meridians and dispels cold. It can not only help clear dampness, turbidity and toxicity in the uterine cavity, but also harmonize qi and blood through its warming and unblocking properties, creating a good internal environment for the proliferation and repair of endometrial cells.

[0034] This application contains no redundant ingredients, and the efficacy of each medicinal herb precisely addresses the multidimensional pathological problems of intrauterine adhesions, achieving "treating both the symptoms and the root cause" rather than simply treating the symptoms.

[0035] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating intrauterine adhesions, characterized in that, It is composed of the following raw materials in parts by weight: 1-20 parts of *Sargentodoxa cuneata*, 5-50 parts of *Patrinia scabiosaefolia*, 5-40 parts of *Lonicera japonica*, 1-40 parts of *Forsythia suspensa*, 1-30 parts of *Sparganium stoloniferum* (processed with vinegar), 1-30 parts of *Curcuma zedoaria*, 5-20 parts of *Paeonia suffruticosa*, 5-35 parts of *Paeonia lactiflora*, 1-30 parts of *Gleditsia sinensis*, 5-30 parts of *Prunella vulgaris*, 5-50 parts of *Liquidambar formosana*, 1-40 parts of *Artemisia argyi*, 1-40 parts of *Hedyotis diffusa*, 1-30 parts of *Lonicera japonica*, 10-50 parts of *Coix lacryma-jobi*, and 5-20 parts of *Prunus persica*.

2. A traditional Chinese medicine composition for treating intrauterine adhesions, characterized in that, It is composed of the following raw materials in parts by weight: 10-40 parts of *Sargentodoxa cuneata*, 10-40 parts of *Patrinia scabiosaefolia*, 10-40 parts of *Lonicera japonica*, 10-30 parts of *Forsythia suspensa*, 5-30 parts of *Sparganium stoloniferum* (processed with vinegar), 1-30 parts of *Curcuma zedoaria*, 1-30 parts of *Paeonia suffruticosa*, 1-40 parts of *Paeonia lactiflora*, 10-40 parts of *Gleditsia sinensis*, 10-40 parts of *Prunella vulgaris*, 10-40 parts of *Liquidambar formosana*, 1-30 parts of *Artemisia argyi*, 10-40 parts of *Hedyotis diffusa*, 1-30 parts of *Lonicera japonica*, 10-50 parts of *Coix lacryma-jobi*, and 1-10 parts of *Prunus persica*.

3. A traditional Chinese medicine enema for treating intrauterine adhesions, characterized in that, A traditional Chinese medicine composition for treating intrauterine adhesions as described in claim 1 or claim 2.

4. The traditional Chinese medicine enema for treating intrauterine adhesions according to claim 3, characterized in that, The herbal enema is prepared by the following steps: First, weigh the herbal composition and soak it in a certain amount of water for 25-35 minutes; then decoct it twice, the first time for 0.5 hours and the second time for 0.3 hours; then combine the decoctions, let them stand for 1 hour, filter them, and take the clear liquid after filtration. Next, bring the filtered liquid to a boil over high heat, then simmer over low heat to concentrate it to 100ml. Finally, boil the concentrated liquid again and dispense it into individual containers.

5. The use of a traditional Chinese medicine composition as described in claim 1 or claim 2 in the preparation of a medicament for treating intrauterine adhesions.