Pure gold gold marker implant with positioning features

Abstract

The present application relates to gold mark implant technology field, disclose a pure gold gold mark implant with positioning features, including at least two markers, through gold mark injector to mark injection;Connecting line is collagen chain, fixed pattern, arranged on the marker, when the marker is located in the target tissue, the target tissue extrudes the fixed pattern, so that the marker can be fixed in the target tissue;The fixed pattern includes a fixed part opened on the marker;Wherein the left view of the marker is a circular structure, wherein two mutually perpendicular axis sections in the marker divide the plan view of the marker into four regions, wherein the fixed part is located in the above region, by setting the limiting groove in the pure gold gold mark, connecting line, mushroom-shaped third fixed part and the structure of multilayer groove, further make the human tissue can enter to cooperate with the barb to realize the fixation work of gold mark implant, avoid the displacement of implant position.

Description

Technical Field

[0001] This invention relates to the field of gold-labeled implant technology, specifically to a pure gold-labeled implant with positioning features. Background Technology

[0002] In the medical field, gold-labeled implants are mainly used for precise positioning and treatment. They can be implanted into lesions such as tumors, serving as markers for accurate imaging identification, guiding subsequent precise radiotherapy, surgical resection, etc. At the same time, their surface can be loaded with drugs or biological factors to achieve local sustained-release therapy and improve treatment efficacy.

[0003] For example, patent application CN106621076A discloses a cobalt-zirconium gold label implant and a gold label implantation device, including a gold label body. The gold label body is made of metallic cobalt-zirconium and has a capsule-shaped or drum-shaped shape. Its outer surface is provided with textures to increase friction. The outer surface of the gold label body is also provided with a drug sustained-release layer.

[0004] The aforementioned technical solution sets various raised textures of different shapes on the capsule-shaped or drum-shaped gold label body. The raised textures enable the target tissue to contact and fix with the gold label body, thereby increasing the contact area between the target tissue and the gold label body and locking the position of the implanted gold label body. However, the above patent application still has some problems. After the implant is installed, the radial positioning of the implant can be achieved through the cooperation between the raised and grooved parts on the target tissue and the implant. However, the axial positioning structure is lacking, which causes the implant position to shift, resulting in the failure of subsequent tumor radiotherapy positioning and disease monitoring.

[0005] Therefore, designing a new pure gold marker implant to avoid significant displacement of the marker is a problem that needs to be solved. Summary of the Invention

[0006] This invention provides a pure gold implant with positioning features to solve the above-mentioned problems existing in the prior art.

[0007] Pure gold implants with positioning features include: At least two markers are injected using a gold-labeled syringe; The connecting line, a collagen chain with a cylindrical structure, is used to connect the ends of two markers. An adhesion pattern set is provided on the marker. When the marker is located in the target tissue, the target tissue squeezes the adhesion pattern set so that the marker can be fixed in the target tissue. The fixing pattern assembly includes a fixing member formed on the marker, wherein the fixing member is arranged along the axial direction of the marker; The left view of the marker is a circular structure, and two mutually perpendicular axial sections of the marker divide the top view of the marker into four regions, wherein the fastener is located within the aforementioned regions; Furthermore, the fastener includes four first fasteners; The first fastener is a comb-shaped structure. The marker is divided into two segments by one of its axial sections, and the segments have the same structure. The two first fasteners on the same segment are staggered and the grooves in the two first fasteners are interconnected.

[0008] Furthermore, the toothed groove in the first fastener includes a first groove, a connecting groove, and a limiting groove. The front view of the first groove is rectangular, and the front view of the connecting groove is a right-angled triangle. The hypotenuse of the right triangle is located on the comb teeth in the first fixing member. There are multiple limiting grooves, and their length direction is horizontal with the radius direction of the marker. The limiting grooves are respectively opened on the first groove and the connecting groove. In the rear view of the marker, the comb teeth in the first fastener have a diamond-shaped structure; The connecting groove in one of the first fixation members located on the same segment is connected to the first groove on the other first fixation member. After the marker is implanted into the target tissue, the target tissue can connect the first groove in the two first fixation members through the connecting groove to limit the axial position of the marker.

[0009] Furthermore, the angle formed by the inclined side of the connecting groove and the bottom extension line of the first groove is between 45 degrees and 60 degrees.

[0010] Furthermore, the fastener includes a second fastener; The second fastener includes two second grooves formed on the marker; The surfaces corresponding to the bottoms of the two second grooves coincide with the axial section of the marker; In the image corresponding to the right view of the marker, the vertices of the second groove are connected sequentially to form an axis of symmetry, and the image corresponding to the right view of the marker is axially symmetric about the aforementioned axis of symmetry.

[0011] Furthermore, the fastener includes a third fastener; The third fastener includes a first protrusion disposed on the comb teeth, a connecting post disposed on the first protrusion, and a fixing block connected to the connecting post; The fixing block is mushroom-shaped.

[0012] Furthermore, the fastener includes a fourth fastener; The fourth fastener includes a second protrusion disposed on the comb teeth, and a plurality of multi-layered grooves disposed on the second protrusion parallel to the axis of the marker. The multi-layered tank includes at least two interconnected adsorption tanks, with the adsorption tank closer to the target tissue being the first attachment tank and the other being the second attachment tank. The bottom of the first attachment groove is connected to the top of the second attachment groove, and the length of the top of the first attachment groove is not less than the length of the bottom of the second attachment groove. The top of the first attachment groove is closer to the target tissue than the bottom of the first attachment groove.

[0013] Furthermore, the fastener includes a fifth fastener; The fifth fastener includes a plurality of annular protrusions disposed on the marker, a storage cavity built into the marker, and a through hole penetrating the marker; The inner wall of the storage cavity is coated with a drug, which comes into contact with the target tissue through a through-hole; Different types of drugs are selected depending on the target of the marker implantation. If the marker is implanted into normal tissue, a drug for tissue repair and regeneration can be applied. Conversely, if it is implanted into cancer cells, an immunomodulatory drug can be applied to the marker to kill cancer cells and increase the body's anti-tumor immune response.

[0014] Furthermore, the marker includes a fixation groove, a placement cavity and a communication cavity formed within the fixation groove, and a therapeutic agent coated in the placement cavity; The fixing groove includes two third through holes formed on the marker, a second through hole connected to one end of the third through hole and having an inclination angle with the third through hole, and a first through hole connected to the second through hole; The two third through holes are connected at one end and are inclined at an angle to each other. The length direction of the first through hole is the same as the length direction of the marker.

[0015] Furthermore, the marker is provided with a placement groove in its circumference, and a barb is provided in the placement groove; The barb is made of nickel-titanium alloy.

[0016] The tail end of the marker is the end closest to the placement groove; the barb, marker, fixing block, connecting column, annular protrusion and multi-layer groove are all provided with limiting protrusions; to increase the contact area between the implant and cell tissue, thereby ensuring the stability of the implant and avoiding displacement of the implant position.

[0017] Beneficial Effects: This invention discloses a pure gold marker implant with positioning features. To prevent significant displacement of the marker, the device incorporates a set of fixing patterns. The marker is divided into four regions using an axial section, and a fixing element is provided in each region. Through the limiting groove, connecting line, mushroom-shaped third fixing element, and multi-layered groove structure in the pure gold marker, human tissue can be inserted to work with the barbs to achieve multi-directional fixation of the gold marker implant, preventing significant displacement of the implant and thus avoiding failure of image detection. Simultaneously, the staggered comb-like structure in the first fixing element, compared to traditional spiral or X-shaped fixing methods, provides better stability. The comb-like structure in this device, whether protruding or other types of protrusions, is simple to manufacture and allows for closer and more uniform contact between the gold implant and surrounding tissues, reducing tissue irritation and damage. It also allows for better embedding into surrounding tissues, enhancing the bonding force between the gold implant and the tissue, reducing the possibility of displacement due to various factors within the body. Finally, it minimizes interference with imaging examinations (such as CT scans), enabling clearer visualization of the gold implant's position and the condition of surrounding tissues, which is beneficial for doctors to accurately determine the precise location of tumors and treatment outcomes. In contrast, bolt-type protrusions in existing technologies may produce more artifacts or interference in imaging, affecting image quality. The first fixation structure in this device is relatively superior. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the marker structure of the present invention; Figure 2 This is a structural diagram of the pure gold gold label implant with positioning features of the present invention; Figure 3 This is a schematic diagram of the second fastener structure of the present invention; Figure 4 This is a schematic diagram of the third fastener structure of the present invention; Figure 5 This is a top view of the third fastener of the present invention; Figure 6 This is a schematic diagram of the fourth fastener structure of the present invention; Figure 7 This is a schematic diagram of the fifth fastener structure of the present invention; Figure 8 This is a schematic diagram of the fixing groove structure of the present invention; Figure 9 This is a schematic diagram of the placement cavity of the present invention; Figure 10 This is a schematic diagram of the bonding pattern assembly of the present invention.

[0019] Explanation of reference numerals in the attached drawings: 1. Marker; 11. Communicating cavity; 12. Placement cavity; 2. Barb; 3. Connecting line; 4. Fixing pattern group; 41. First fixing element; 42. Second fixing element; 43. Third fixing element; 431. Connecting post; 432. Fixing block; 433. First protrusion; 44. Fourth fixing element; 443. Second protrusion; 45. Fifth fixing element; 451. Annular protrusion; 452. Through hole; 453. Storage cavity; 46. Fixing groove; 461. First through hole; 462. Second through hole; 463. Third through hole; 5. Placement groove. Detailed Implementation

[0020] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0021] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0022] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places throughout this specification does not necessarily refer to the same embodiment, nor is it a single embodiment or an embodiment selectively excluded from other embodiments.

[0023] This invention discloses a pure gold implant with positioning features, referring to... Figures 1-10 ,include: At least two markers 1 are injected into the markers 1 using a gold-labeled syringe; connecting lines 3, which are collagen chains in cylindrical shape, are used to connect the tail ends of the two markers 1; an attachment pattern group 4 is disposed on the markers 1, and when the markers 1 are located in the target tissue, the target tissue compresses the attachment pattern group 4, allowing the markers 1 to be fixed in the target tissue; the attachment pattern group 4 includes a fixation element disposed on the markers 1, wherein the fixation element is disposed along the axial direction of the markers 1; wherein the left view of the markers 1 is a circular structure, wherein two mutually perpendicular axial sections of the markers 1 divide the top view of the markers 1 into four regions, wherein the fixation element is located within the aforementioned regions; by setting a pure gold... The structure of the limiting groove, connecting line 3, mushroom-shaped third fixing element 43, and multi-layer groove in the label allows human tissue to extend into it, thereby cooperating with the barb 2 to fix the gold label implant and prevent large displacement of the implant, which would lead to failure of image detection. At the same time, the connecting line 3, which is longer than 2 cm, and the connecting line 3 with a length of 2.5 cm, can adjust the spacing between adjacent gold label implants to prevent the distance between two adjacent gold label implants from being too large or too small, which would affect the imaging and marking effect of the gold label. The free ends or other sharp parts of the five fixing groups in the barb 2 and fixing pattern group 4 all have a predetermined curvature to avoid damage to tissue cells.

[0024] The fastener includes four first fasteners 41; each first fastener 41 has a comb-like structure, and the marker 1 is divided into two identical sections by one of its axial sections. Two first fasteners 41 on the same section are staggered, and the grooves in the two first fasteners 41 are interconnected. Each groove in the first fastener 41 includes a first groove, a connecting groove, and a limiting groove. The front view of the first groove is rectangular, and the front view of the connecting groove is a right-angled triangle. The hypotenuse of the right-angled triangle is located on the comb teeth of the first fastener 41. Multiple limiting grooves are provided, their length direction being horizontal to the radius direction of the marker 1, and they are respectively located on the first groove and the connecting groove. In the rear view of the marker 1, the comb teeth in the first fastener 41 have a rhomboid structure. The connecting groove in one of the first fasteners 41 on the same section is connected to the groove in the other first fastener. The first groove on the fixation member 41 is connected. After the marker 1 is implanted into the target tissue, the target tissue can connect the first grooves in the two first fixation members 41 through the connecting groove to limit the axial position of the marker 1. Through the connecting groove, after the position of the gold marker implant is fixed, the target tissue can squeeze the gold marker implant or grow, so that the target tissue can fill the first groove, the connecting groove and the limiting groove. Since the connecting groove connects the two first grooves and the limiting groove is inclined, while the marker 1 is radially limited, the tissue in the connecting groove can axially fix the marker 1, so that the marker 1 can be axially limited, avoiding excessive movement of the organ (lung) where the gold marker is located, which would cause a large displacement of the gold marker position, or displacement of the gold marker due to other reasons.

[0025] The angle formed by the inclined side of the connecting groove and the bottom extension line of the first groove is between 45 degrees and 60 degrees. By making the angle of the inclined side of the connecting groove between 45° and 60°, the tissue located in the connecting groove can fix the gold mark axially, preventing the gold mark from shifting. At the same time, it ensures that the tissue located in the connecting groove is not too thin, so that when the gold mark moves axially, the tissue in this area can play a limiting role, preventing the tissue in this area from breaking and causing the gold mark to shift.

[0026] The fixation element includes a second fixation element 42; the second fixation element 42 includes two second grooves formed on the marker 1; the surfaces corresponding to the bottom of the two second grooves coincide with the axial section of the marker 1; in the image corresponding to the right view of the marker 1, the vertices of the second grooves are connected in sequence to form an axis of symmetry, and the image corresponding to the right view of the marker 1 is axially symmetric about the above-mentioned axis of symmetry; the second grooves, through the compression of the target tissue, can limit the gold label implant, ensuring that the gold label implant can be placed in the predetermined position.

[0027] The fastener includes a third fastener 43; the third fastener 43 includes a first protrusion 433 disposed on the comb teeth, a connecting post 431 disposed on the first protrusion 433, and a fixing block 432 connected to the connecting post 431; the fixing block 432 is mushroom-shaped; the diameter of the fixing block 432 is between 0.5-2 mm, the diameter of the connecting post 431 is between 0.2-0.8 mm, and the length of the connecting post 431 is between 0.8-3 mm. The fastener is controlled by adjusting the fixing block 432 and... The dimensions of the connecting post 431 ensure the stability of the third fixing member 43 and prevent excessive compression of the target tissue, which could cause damage and local inflammation. Meanwhile, the mushroom-shaped fixing block 432 allows the top and back surfaces of the fixing block 432 to abut against the target tissue after the target tissue wraps around the marker 1. Since the top surface of the fixing block 432 is arc-shaped, it increases the contact area with the target tissue, thereby increasing the adsorption effect of the gold marker and preventing the position of the gold marker from changing.

[0028] The attachment includes a fourth attachment 44; the fourth attachment 44 includes a second protrusion 443 disposed on the comb teeth, and a plurality of multi-layered grooves disposed on the second protrusion 443 parallel to the axis of the marker 1; the multi-layered grooves include at least two connected adsorption grooves, the adsorption groove closer to the target tissue is the first attachment groove, and the other is the second attachment groove; wherein the bottom of the first attachment groove is connected to the top of the second attachment groove and the top length of the first attachment groove is not less than the bottom length of the second attachment groove, and the top of the first attachment groove is closer to the target tissue than the bottom of the first attachment groove; the above structure is conducive to the formation of a stable support structure when tissue cells grow in the groove, preventing cells from falling out of the groove during the growth process; at the same time, the trapezoidal cross section is also convenient to be realized by machining or mold forming and other processes during the manufacturing process; The connection between the first attachment groove and the second attachment groove can also be as follows: the top of the first attachment groove is connected to the bottom of the second attachment groove, and the bottom of the first attachment groove is close to the target tissue; the first attachment groove can guide human tissue cells to grow in, accelerate the biofusion of the implant with the surrounding tissue, reduce the risk of immune rejection, and improve the biocompatibility of the implant; the first attachment groove can accommodate more tissue fibers and blood vessels to grow in, providing nutritional support for the tissue; while the second attachment groove is used to promote the directional growth and tight arrangement of cells; ensuring that tissue cells can deeply strengthen biological locking.

[0029] The fixation element includes a fifth fixation element 45; the fifth fixation element 45 includes a plurality of annular protrusions 451 disposed on the marker 1, a storage cavity 453 built into the marker 1, and a through hole 452 penetrating the marker 1; the inner wall of the storage cavity 453 is coated with a drug, and the drug contacts the target tissue through the through hole 452; when the implant is located in the target tissue, the drug begins to be released and contacts the target tissue through the through hole 452. When the drug coated in the storage cavity 453 acts to generate cells, the target tissue enters the marker 1 through the through hole 452, thereby allowing the generated target tissue to pass through the through hole 452, thus fixing the gold marker implant. When the drug acts to inactivate the tumor, the drug can contact the target tissue through the through hole 452, thereby inactivating the tumor at the specified location.

[0030] The marker 1 includes a fixation groove 46, a placement cavity 12 and a connecting cavity 11 formed within the fixation groove 46, and a therapeutic agent coated in the placement cavity 12; the fixation groove 46 includes two third through holes 463 formed on the marker 1, a second through hole 462 connected to one end of each third through hole 463 and having an angle between them, and a first through hole 461 connected to the second through hole 462; the two third through holes 463 are connected at one end and have an angle between them, and the first through hole 461... The length direction of 461 is the same as that of marker 1; a cell-generating agent is placed in the placement cavity 12 or coated on its inner wall. At this time, the agent can diffuse toward the first through hole 461. The coated agent can fill the fixation groove 46. Since the fixation groove 46 has a serrated structure, it can prevent the gold label implant from axially displacing, thereby completing the fixation of the gold label implant. At the same time, the target tissue can also fill the placement cavity 12 and the connecting cavity 11, increasing the stability of the gold label implant and preventing large displacement of the gold label.

[0031] The marker 1 is further provided with a placement groove 5 in the circumferential direction, and a barb 2 is provided in the placement groove 5; the barb 2 is made of nickel-titanium alloy; the barb 2 is a shape memory metal, which is located in the placement groove 5 at room temperature. When it is placed in the human body, the body temperature in the human body causes the barb 2 to return to its original shape, so that the barb 2 can penetrate into the target tissue, avoid damage to the barb 2 during injection using the injection tube, ensure the safety of the implant, and maintain the stability of the implant.

[0032] Working principle description: When gold marker implantation is required, the gold marker is placed in a syringe and then injected. When the gold marker is in the human body, the body temperature causes the barb 2 to change shape, allowing it to penetrate into the target tissue. Then, the drug in the placement cavity 12 or storage cavity 453 begins to diffuse, allowing the generated target tissue to enter the through hole 452. This allows the newly generated target tissue to pass through the through hole 452, thus fixing the marker 1. The first fixing member 41, the second fixing member 42, the third fixing member 43, the fourth fixing member 44, and the fifth fixing member 45 are set to fix and limit the gold marker implant, preventing displacement of the implant.

[0033] The preferred embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the specific details of the above embodiments. Within the scope of the technical concept of the present invention, various equivalent transformations can be made to the technical solutions of the present invention, and all such equivalent transformations fall within the protection scope of the present invention.

Claims

1. A pure gold implant with positioning features, characterized in that, include: At least two markers (1) are injected into the markers (1) using a gold-labeled syringe; The connecting line (3) is a collagen chain with a columnar structure, used to connect the tail ends of the two markers (1); The fixation pattern group (4) is set on the marker (1). When the marker (1) is located in the target tissue, the target tissue squeezes the fixation pattern group (4) so ​​that the marker (1) can be fixed in the target tissue. The fastening pattern group (4) includes a fastening element formed on the marker (1), wherein the fastening element is arranged along the axial direction of the marker (1); The left view of the marker (1) is a circular structure, and the top view of the marker (1) is divided into four regions by two mutually perpendicular axial sections, wherein the fastener is located in the aforementioned regions. The fasteners include four first fasteners (41); The first fastener (41) has a comb-like structure. The marker (1) is divided into two segments by one of its axial sections and the segments have the same structure. The two first fasteners (41) on the same segment are staggered and the grooves in the two first fasteners (41) are interconnected. The toothed groove in the first fastener (41) includes a first groove, a connecting groove and a limiting groove. The front view of the first groove is a rectangle and the front view of the connecting groove is a right triangle.

2. The pure gold implant with positioning features according to claim 1, characterized in that: The hypotenuse of the right triangle is located on the comb teeth in the first fastener (41). There are multiple limiting grooves and their length direction is horizontal with the radius direction of the marker (1). The limiting grooves are respectively opened on the first groove and the connecting groove. In the rear view of the marker (1), the comb teeth in the first fastener (41) have a diamond-shaped structure; The connecting groove in one of the first fasteners (41) located on the same segment is connected to the first groove on the other first fastener (41). After the marker (1) is implanted into the target tissue, the target tissue can connect the first grooves located in the two first fasteners (41) through the connecting groove to limit the axial position of the marker (1).

3. The pure gold implant with positioning features according to claim 2, characterized in that: The angle formed by the inclined side of the connecting groove and the bottom extension line of the first groove is between 45 degrees and 60 degrees.

4. The pure gold implant with positioning features according to claim 2, characterized in that: The fastener includes a third fastener (43); The third fastener (43) includes a first protrusion (433) disposed on the comb teeth, a connecting post (431) disposed on the first protrusion (433), and a fixing block (432) connected to the connecting post (431). The fixing block (432) is mushroom-shaped.

5. The pure gold implant with positioning features according to claim 2, characterized in that: The fastener includes a fourth fastener (44); The fourth fastener (44) includes a second protrusion (443) disposed on the comb teeth, and a plurality of multi-layered grooves disposed on the second protrusion (443) parallel to the axis of the marker (1); The multi-layered tank includes at least two interconnected adsorption tanks, with the adsorption tank closer to the target tissue being the first attachment tank and the other being the second attachment tank. The bottom of the first attachment groove is connected to the top of the second attachment groove, and the length of the top of the first attachment groove is not less than the length of the bottom of the second attachment groove. The top of the first attachment groove is closer to the target tissue than the bottom of the first attachment groove.

6. The pure gold implant with positioning features according to any one of claims 3 or 5, characterized in that: The marker (1) includes a fixation groove (46), a placement cavity (12) and a communication cavity (11) opened in the fixation groove (46), and a therapeutic agent coated in the placement cavity (12); The fixing groove (46) includes two third through holes (463) opened on the marker (1), a second through hole (462) connected to one end of the third through hole (463) and having an inclination angle with the third through hole (463), and a first through hole (461) connected to the second through hole (462). Two third through holes (463) are connected at one end and have an angle between them. The length direction of the first through hole (461) is the same as the length direction of the marker (1).

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