Biochemical sample intelligent sealing and transporting device

Abstract

The application provides a biochemical sample intelligent sealing transportation device, which solves the problem that the physical state of leaked biochemical samples cannot be changed in a reagent tube storage and transportation container, and the structure in the box is easily polluted and corroded. The application comprises an open-top box body and a box cover arranged on the top of the box body. An inner part of the box body is provided with a test tube storage space. A detachable test tube rack is arranged in the test tube storage space. A plurality of test tubes capable of being taken out and placed are arranged on the test tube rack. A detachable plug is arranged on the top of the test tube. A second partition plate is fixedly arranged on the inner side wall of the box cover. An array of plasmas is arranged at the bottom of the second partition plate. A storage box is fixedly arranged on the inner wall of the test tube storage space. The storage box is arranged below the test tube rack. The storage box is used for storing a powdery superabsorbent polymer. A discharge pipe is arranged at the bottom of the storage box. A fifth electromagnetic valve is arranged on the discharge pipe. The fifth electromagnetic valve is connected with a controller in control.

Description

Technical Field

[0001] This invention relates to the field of biochemical sample and transportation and storage technology, and in particular to an intelligent sealed transportation device for biochemical samples. Background Technology

[0002] Biochemical samples, after being collected and stored in test tubes, typically need to be transported to testing centers via specialized storage and transport containers. Existing storage and transport containers mostly provide impact protection, but they cannot be sterilized in a timely manner during use, potentially posing a serious threat to the lives of personnel transporting biochemical samples.

[0003] To solve the above technical problems, the invention application with application number 202211451232.X discloses a nucleic acid detection reagent tube storage and transportation container with disinfection and sterilization function, including a box body and a box cover rotatably connected to the box body. A plasma electrode array is fixedly connected to the inside of the box cover. The plasma electrode array is electrically connected to an intelligent controller through a connecting line. The intelligent controller is electrically connected to an external power supply and a reserve power supply. However, the device still has the following disadvantages when in use: (1) For liquid biochemical samples, when they leak from the test tube, relying solely on the plasma electrode array for disinfection is not only inefficient, but also cannot change the physical state of the leaked biochemical sample. Liquid biochemical samples are not only easy to volatilize, but also easy to contaminate and corrode the internal structure of the box. The transportation container is also prone to leakage when it is opened; (2) During transportation, the internal air pressure of the transportation container is basically the same as the external air pressure, which makes it easy for the biochemical sample to escape from the gaps in the transportation container when it leaks. Summary of the Invention

[0004] To address the problem in the prior art that reagent tube storage and transportation containers cannot alter the physical state of leaked biochemical samples, easily leading to contamination and corrosion of the internal structure, this invention proposes an intelligent sealed transportation device for biochemical samples.

[0005] The technical solution of the present invention is: a smart sealed transport device for biochemical samples, including a box with an opening at the top and a box cover on the top of the box. The box has a vertically arranged first partition inside, which divides the inside of the box into two independent test tube storage spaces and a power supply space. A power supply is installed in the power supply space.

[0006] The test tube storage space is equipped with a detachable test tube rack, which holds several test tubes that can be placed and removed. The test tubes are equipped with detachable plugs at the top. The test tube rack is equipped with several rotatable pressure plates that are used to press against the top edge of the plugs. The test tube rack has a ventilation structure that allows air to pass through from top to bottom.

[0007] A second partition is fixedly installed on the inner wall of the box cover. A gap is left between the second partition and the top of the box cover. A controller is installed on the top of the second partition and is electrically connected to the power supply. A plasma array is installed at the bottom of the second partition and is electrically connected to the controller.

[0008] A storage box is fixedly installed on the inner wall of the test tube storage space. The storage box is located below the test tube rack. The storage box contains powdered superabsorbent polymer. A discharge pipe is installed at the bottom of the storage box. A fifth solenoid valve is installed on the discharge pipe. The fifth solenoid valve is connected to the controller.

[0009] The inner wall of the test tube storage space is equipped with a temperature and humidity sensor and a triaxial accelerometer, both of which are connected to the controller.

[0010] The side wall of the box has a slot that connects to the test tube storage space. A cold source storage box that extends into the test tube storage space is inserted into the slot. The cold source storage box contains ice packs. A baffle is fixed to the end of the cold source storage box. The area of ​​the baffle is larger than the area of ​​the slot. The baffle is detachably connected to the side wall of the box.

[0011] Preferably, an elastic sealing gasket is fixedly provided at the bottom of the second partition, and the sealing gasket is pressed against the top of the first partition. A semiconductor cooling chip is provided on the side of the first partition facing the test tube storage space. The semiconductor cooling chip is located above the test tube rack and is connected to the controller.

[0012] Preferably, the ventilation structure includes a first ventilation hole and a second ventilation hole. The first ventilation hole is located on the outside of the test tube, and the second ventilation hole is located between adjacent test tubes. A ventilation fan is provided at the top of the second ventilation hole, and the airflow direction of the ventilation fan is from top to bottom. The ventilation fan is connected to a controller.

[0013] Preferably, an air pump is provided at the top of the second partition, the air pump is connected to the controller, the air inlet of the air pump is connected to one end of the suction pipe, the other end of the suction pipe passes through the second partition and communicates with the test tube storage space, and a first one-way valve is provided on the suction pipe.

[0014] The air pump's outlet is connected to one end of the exhaust pipe, and the other end of the exhaust pipe is connected to the bottom of the exhaust port. The exhaust port is embedded in the top of the box cover, and a filter structure is installed inside the exhaust port.

[0015] A second pressure sensor is installed on the inner wall of the test tube storage space, and the second pressure sensor is connected to the controller.

[0016] Preferably, the bottom of the second partition is fixed with a circumferential annular groove plate. The vertical section of the annular groove plate is an L-shaped structure. The side of the annular groove plate facing the box body is provided with an annular mounting groove. A sealing airbag is installed in the mounting groove. The side of the sealing airbag away from the annular groove plate can be fully covered and attached to the joint between the box body and the box cover.

[0017] The sealing airbag is connected to one end of the inflation tube, and the other end of the inflation tube passes through the second partition and is connected to the exhaust pipe. The inflation tube is equipped with a second solenoid valve, and the exhaust pipe is equipped with a first solenoid valve. The first solenoid valve is located between the exhaust port and the connection node between the inflation tube and the exhaust pipe. The sealing airbag is connected to one end of the venting tube, and the other end of the venting tube passes through the annular groove plate and communicates with the test tube storage space. The venting tube is equipped with a third solenoid valve. The first, second, and third solenoid valves are respectively connected to the controller.

[0018] Preferably, the storage box is an annular box structure surrounding the test tube, and the bottom of the storage box is provided with multiple discharge pipes at equal intervals along its circumference. Each discharge pipe is provided with a fifth solenoid valve, and all the fifth solenoid valves are connected in series and then connected to the controller for control.

[0019] The upper part of the storage box is connected to a feed pipe, which is equipped with a second check valve and a fourth solenoid valve. The second check valve is located between the fourth solenoid valve and the storage box, and the fourth solenoid valve is connected to the controller.

[0020] The storage box is filled with pressurized gas so that the internal pressure of the storage box is greater than the air pressure in the test tube storage space.

[0021] Preferably, an annular groove is formed on the side wall of the plug, an electrode pin is provided on the inner wall of the annular groove, the annular groove is filled with liquid metal that is electrically connected to the electrode pin, and a flexible isolation film for sealing is provided at the opening of the annular groove. One side of the flexible isolation film is in contact with the liquid metal, and the other side of the flexible isolation film is in contact with the inner wall of the test tube.

[0022] The top of the plug is equipped with a circuit board, which is electrically connected to the electrode pins and the controller.

[0023] Preferably, a first pressure sensor for monitoring the internal pressure of the test tube is embedded at the bottom of the plug, and an electronic tag is provided at the top of the plug. Both the electronic tag and the first pressure sensor are communicatively connected to the circuit board.

[0024] Preferably, the test tube storage space is provided with a support plate, one end of which is fixedly connected to the first partition. The top of the first partition is fixedly provided with several elastic bases, and the top of the bases is provided with slots that fit the lower end of the test tubes. The lower end of the test tubes is inserted into the slots.

[0025] Preferably, the top of the box lid is equipped with a touch screen display and a warning light, both of which are connected to the controller;

[0026] The side wall of the chamber is equipped with a transparent observation window, which corresponds to the inside and outside of the test tube.

[0027] Advantages of the present invention: (1) Multiple active seals, extremely high safety: Through the triple sealing design of mechanical pressing, liquid metal contact sealing and inflatable sealing airbag, especially the dynamic seal created by the airbag, the overall sealing level of the box is greatly improved.

[0028] (2) The negative pressure environment design is the key to the safety of this invention. It can effectively control any potential leakage risk inside the box, prevent the escape of biological harmful substances, and protect the environment and personnel safety. At the same time, during the process of forming a negative pressure environment, the airbag can also be inflated, so that the airbag expands and is tightly pressed against the joint between the box and the lid, achieving dynamic sealing.

[0029] (3) Intelligent Leak Detection and Emergency Response: It realizes dual leakage monitoring at the "pipe level" and "box level". It can not only detect abnormalities inside the box, but also accurately locate which test tube has a problem, which facilitates rapid response.

[0030] (4) The integrated powdered superabsorbent polymer absorption system can quickly and automatically solidify leaked liquid biochemical samples, avoiding cross-contamination, cleaning difficulties, and corrosion of the internal structure caused by the flow of liquid biochemical samples, thus minimizing the hazards of leakage. Combined with the plasma disinfection function, the internal environment and biochemical samples leaked into the air inside the box can be purified during or before transportation, maximizing the avoidance of problems caused by biochemical sample leakage to the external environment.

[0031] (5) Precise and reliable environmental maintenance: The combination of active cooling by semiconductor cooling chips and forced circulation by fans ensures precise control and high uniformity of temperature inside the chamber, which is superior to passive insulation methods that rely solely on ice packs. The modular cold source design (ice pack box) complements the active cooling system, providing a flexible and reliable insulation solution.

[0032] (6) Comprehensive state perception and traceability: It integrates multiple sensors such as temperature and humidity, triaxial acceleration, internal and external pressure, and comprehensively records the environmental and physical state of the sample during the entire transportation process, providing detailed data support for sample quality assessment and responsibility traceability. Attached Figure Description

[0033] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0034] Figure 1 This is a schematic diagram of the internal main structure of Example 1;

[0035] Figure 2 for Figure 1 A schematic diagram of the external main structure;

[0036] Figure 3 for Figure 1 A schematic diagram of the test tube rack and test tubes in the diagram;

[0037] Figure 4 for Figure 3 Enlarged view of the structure at point A in the image;

[0038] Figure 5 for Figure 1 Enlarged view of the structure at point B in the image;

[0039] Figure 6 for Figure 1 Enlarged view of the structure at point C in the image;

[0040] In the diagram, 1. Box body, 2. First partition, 3. Box cover, 4. Support edge, 5. Test tube rack, 6. Test tube, 7. Plug, 8. Electrode pin, 9. Liquid metal, 10. Electronic tag, 11. Circuit board, 12. First pressure sensor, 13. Fixing tube, 14. Screw, 15. Pressure plate, 16. First ventilation port, 17. Second ventilation port, 18. Ventilation fan, 19. Support plate, 20. Base, 21. Cold storage box, 22. Cold source placement space, 23. Cover plate, 24. Ice pack, 25. Insulation board, 26. Baffle, 27. Bolt, 28. Power supply partition, 29. Power supply, 30. Semiconductor cooling chip, 31. Second partition, 32. Controller, 33. 34. Plasma array, 35. Sealing gasket, 36. Air pump, 37. Suction pipe, 38. First one-way valve, 39. Exhaust pipe, 40. First solenoid valve, 41. Exhaust port, 42. Inflation pipe, 43. Second solenoid valve, 44. Annular groove plate, 45. Sealing airbag, 46. Third solenoid valve, 47. Second pressure sensor, 48. Temperature and humidity sensor, 49. Triaxial accelerometer, 50. Storage box, 51. Superabsorbent polymer, 52. Feed pipe, 53. Second one-way valve, 54. Fourth solenoid valve, 55. Fifth solenoid valve, 56. Handle, 57. Touch screen, 58. Warning light, 59. Lock, 50. Observation window. Detailed Implementation

[0041] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0042] Example 1: A smart sealed transport device for biochemical samples, such as Figure 1 As shown, the box includes a box body 1 with an upper opening and a box cover 3 located on the top of the box body 1. The box cover 3 and one end of the box body 1 are connected by a hinge, and the other end of the box cover 3 and the box body 1 are detachably connected by a latch 58.

[0043] The interior of the chamber 1 is equipped with a vertically arranged first partition 2, which divides the interior of the chamber 1 into two independent test tube storage spaces and a power supply space. To improve the internal gas independence between the test tube storage space and the power supply space, such as... Figure 1 As shown, an elastic sealing gasket 34 is fixedly provided at the bottom of the second partition 31, and the sealing gasket 34 is pressed against the top of the first partition 2.

[0044] Two power supply partitions 28 are fixedly arranged on the left and right sides in the power supply space. A power supply 29 is inserted between the two power supply partitions 28. A Z-shaped fixing plate is connected to the top of the power supply 29 by screws. The top of the Z-shaped fixing plate away from the power supply 29 is fixedly connected to the first partition 2.

[0045] A second partition 31 is fixedly provided on the inner side wall of the box cover 3. A gap is left between the second partition 31 and the top of the box cover 3. A controller 32 is provided on the top of the second partition 31. The controller 32 is electrically connected to the power supply 29. A plasma array 33 is provided on the bottom of the second partition 31. The plasma array 33 is electrically connected to the controller 32. In this embodiment, the controller 32 is a single-chip microcomputer.

[0046] A semiconductor cooling chip 30 is provided on the side of the first partition 2 facing the test tube storage space. The semiconductor cooling chip 30 is located above the test tube rack 5 and is connected to the controller 32 for control.

[0047] The sealing gasket 34 ensures the airtightness of the cooling space, improving cooling efficiency. The semiconductor cooling chip 30 provides active and precise temperature control capabilities. The controller can precisely adjust the temperature of the test tube storage space based on feedback from the temperature and humidity sensor 47, maintaining it within the specific low temperature range required for biochemical samples, which is superior to the temperature control effect of simply using ice packs.

[0048] To prevent biochemical samples from leaking from test tube 6 and escaping into the outside air through the gap between the box body 1 and the lid 3, and to improve the tightness of the connection between the box body 1 and the lid 3 during use through the principle of negative pressure, such as... Figure 1 and Figure 5 As shown, an air pump 35 is provided on the top of the second partition 31. The air pump 35 is connected to the controller 32. The air inlet of the air pump 35 is connected to one end of the suction pipe 36. The other end of the suction pipe 36 passes through the second partition 31 and communicates with the test tube storage space. A first one-way valve 37 is provided on the suction pipe 36. The air outlet of the air pump 35 is connected to one end of the exhaust pipe 38. The other end of the exhaust pipe 38 is connected to the bottom of the exhaust port 40. The exhaust port 40 is embedded in the top of the box cover 3. A filter structure is provided inside the exhaust port 40.

[0049] The bottom of the second partition 31 is fixed with a circumferential annular groove plate 43. The vertical section of the annular groove plate 43 is L-shaped. The side of the annular groove plate 43 facing the box body 1 is provided with an annular mounting groove. A sealing airbag 44 is installed in the mounting groove. The side of the sealing airbag 44 away from the annular groove plate 43 can be fully covered and attached to the joint between the box body 1 and the box cover 3. The sealing airbag 44 is connected to one end of the inflation pipe 41. The other end of the inflation pipe 41 passes through the second partition 31 and is connected to the exhaust pipe 38. The inflation pipe 41 is provided with a second solenoid valve 42. The exhaust pipe 38 is provided with a first solenoid valve 39. The first solenoid valve 39 is located between the exhaust port 40 and the connection node between the inflation pipe 41 and the exhaust pipe 38. The sealing airbag 44 is connected to one end of the venting pipe. The other end of the venting pipe passes through the annular groove plate 43 and communicates with the test tube storage space. The venting pipe is provided with a third solenoid valve 45. The first solenoid valve 39, the second solenoid valve 42, and the third solenoid valve 45 are respectively connected to the controller 32 for control.

[0050] During the negative pressure environment creation process, the air pump 35 generates gas to inflate the sealing airbag 44, causing it to expand and tightly press against the seam between the box and the lid, achieving a superior dynamic seal. When it is necessary to open the box, the third solenoid valve 45 is opened to release the air from the sealing airbag 44, allowing the lid 3 to be easily opened. This structure achieves an automatic upgrade in the sealing level.

[0051] A support edge 4 is fixedly installed inside the test tube storage space. A test tube rack 5 is detachably connected to the top of the support edge 4 via bolts. Figure 3 As shown, the test tube rack 5 is a plate-shaped structure with several test tube mounting holes. Test tubes 6 that can be placed and removed are inserted into the test tube mounting holes, and the top edge of the test tubes 6 rests on the top of the test tube rack 5.

[0052] The top of test tube 6 is fitted with a removable plug 7, such as... Figure 4 As shown, in order to determine whether there is any leakage of the biochemical sample in test tube 6, such as... Figure 4As shown, an annular groove is formed on the side wall of the plug 7, and electrode pins 8 are provided on the inner wall of the annular groove. The annular groove is filled with liquid metal 9 (such as gallium-indium alloy) that is electrically connected to the electrode pins 8. A flexible insulating film for sealing is provided at the opening of the annular groove. One side of the flexible insulating film is in contact with the liquid metal 9, and the other side of the flexible insulating film is in contact with the inner wall of the test tube 6. In this embodiment, the flexible insulating film needs to be made of a flexible, temperature-resistant, highly thermally conductive, and chemically inert material, such as polyimide film.

[0053] The top of the plug 7 is provided with a circuit board 11, which is electrically connected to the electrode pin 8 and the controller 32. Each circuit board 11 is connected to the controller 32 through a conductive spring pin and a wire that are plugged in and plugged in. This is the prior art, and its structure will not be described in detail in this embodiment.

[0054] The bottom of the plug 7 is embedded with a first pressure sensor 12 for monitoring the internal pressure of the test tube 6, and the top of the plug 7 is provided with an electronic tag 10. Both the electronic tag 10 and the first pressure sensor 12 are connected to the circuit board 11.

[0055] To further improve the stability of the plug 7 and test tube 6 during transportation, such as Figure 4 As shown, a fixing tube 13 is fixedly installed on the test tube rack 5 around the plug 7. A screw 14 is inserted into the fixing tube 13 and threadedly connected to it. A rotatable pressure plate 15 is fitted on the screw 14. The screw 14 is used to fix the pressure plate 15 to the top edge of the plug 7.

[0056] The test tube rack 5 has a ventilation structure that allows air to pass through from top to bottom. The ventilation structure includes a first ventilation hole 16 and a second ventilation hole 17. The first ventilation hole 16 is located on the outside of the test tube 6, and the second ventilation hole 17 is located between adjacent test tubes 6. A ventilation fan 18 is installed at the top of the second ventilation hole 17, and the airflow direction of the ventilation fan 18 is from top to bottom. The ventilation fan 18 is connected to the controller 32 for control. The active fan drives the cold air to circulate from top to bottom, forcing the cold air to flow around all the test tubes, completely eliminating temperature dead zones and ensuring the uniformity and stability of the temperature throughout the space.

[0057] A storage box 49 is fixedly installed on the inner wall of the test tube storage space. The storage box 49 is a ring-shaped box structure surrounding the test tube 6 and is located below the test tube rack 5. The storage box 49 stores powdered superabsorbent polymer 50. Multiple discharge pipes are evenly spaced along the circumference of the bottom of the storage box 49, and each discharge pipe is equipped with a fifth solenoid valve 54. All the fifth solenoid valves 54 are connected in series and controlled by the controller 32. The upper part of the storage box 49 is connected to the feed pipe 51, which is equipped with a second one-way valve 52 and a fourth solenoid valve 53. The second one-way valve 52 is located between the fourth solenoid valve 53 and the storage box 49. The fourth solenoid valve 53 is controlled by the controller 32. The storage box 49 is filled with pressurized gas to make the internal pressure of the storage box 49 greater than the air pressure in the test tube storage space. When the test tube accidentally breaks and causes liquid leakage, the controller can open the fifth solenoid valve 54 to release the superabsorbent polymer 50. The superabsorbent polymer 50 can quickly absorb leaked biochemical sample liquid and solidify it into a gel, preventing the biochemical sample liquid from flowing and spreading inside the tank, causing secondary pollution and corrosion, and also facilitating cleaning.

[0058] The annular design of the storage box 49 and multiple discharge ports ensure that the superabsorbent polymer 50 can be quickly and evenly released to the leak point regardless of where the leak occurs, improving the efficiency and reliability of responding to sudden leaks. The pre-pressurization design, combined with the second one-way valve 52 and the negative pressure condition within the housing 1, ensures that when polymer release is needed, simply opening the fifth solenoid valve 54 allows the internal positive pressure to quickly "push" the powder out, eliminating the need for an additional delivery pump; the structure is simple and reliable. The feed pipe 51 and the fourth solenoid valve 53 facilitate the external replenishment of new superabsorbent polymer during maintenance.

[0059] The inner wall of the test tube storage space is equipped with a second pressure sensor 46, a temperature and humidity sensor 47, and a triaxial acceleration sensor 48. The second pressure sensor 46, the temperature and humidity sensor 47, and the triaxial acceleration sensor 48 are all connected to the controller 32.

[0060] The test tube storage space is provided with a support plate 19. One end of the support plate 19 is fixedly connected to the first partition 2. Several elastic bases 20 are fixedly provided on the top of the first partition 2. The top of the base 20 is provided with a slot that fits the lower end of the test tube 6. The lower end of the test tube 6 is inserted into the slot.

[0061] A slot communicating with the test tube storage space is provided on the side wall of the housing 1. A cold source storage box extending into the test tube storage space is inserted into the slot. The cold source storage box is located below the support plate 19. Figure 1As shown, the cold source storage box includes a top-opening cold storage box 21, which is made of a thermally conductive material. The top of the cold storage box 21 has a removable cover 23. Inside the cold storage box 21 is a cold source placement space 22, which stores ice packs 24. To prevent a thermal bridge from forming between the interior and exterior of the box 1 through the cold storage box 21, thus reducing the cold source utilization efficiency, such as... Figure 1 As shown, one end of the cold storage box 21 is connected to one end of the insulation board 25. The insulation board 25 is movably inserted into the slot. The other end of the insulation board 25 is fixedly provided with a baffle 26. The area of ​​the baffle 26 is larger than the area of ​​the slot. The baffle 26 is detachably connected to the side wall of the box 1 by bolts 27. The side wall of the box 1 is provided with an internal threaded slot that is threadedly connected to the bolts 27. The internal threaded slot is a blind hole structure at one end.

[0062] The cold storage box provides a flexible and replaceable passive refrigeration method, which complements or backs up the active refrigeration system (semiconductor cooling chip), extends the continuous refrigeration time, and avoids the risk of rapid refrigeration failure caused by an unexpected power outage of the active refrigeration system of box 1.

[0063] To facilitate understanding the internal structure of box 1, such as Figure 1 and Figure 2 As shown, the top of the box cover 3 is equipped with a touch screen 56 and a warning light 57. Both the touch screen 56 and the warning light 57 are connected to the controller 32. The side wall of the box body 1 is equipped with a transparent observation window 59, which corresponds to the inside and outside of the test tube 6.

[0064] Working Principle: The core working principle of this invention lies in achieving the safety, quality preservation, and traceability of biochemical samples during transportation through the synergistic effect of intelligent sensing, active control, and multiple protection measures. Its workflow is as follows:

[0065] (1) Preparation and loading: Insert the test tubes 6 containing biochemical samples into the elastic base 20 at the bottom of the test tube rack 5 in sequence to ensure that the bottom of the test tubes is buffered and fixed.

[0066] The smart plug 7, which contains liquid metal 9, a first pressure sensor 12, and an electronic tag 10, is tightly sealed onto the test tube 6.

[0067] Rotate the pressure plate 15 to press it tightly against the edge of the plug 7, completing the mechanical locking of the plug 7. Connect the conductive spring pin, which is connected to the controller 32, to the circuit board 11. Through the buttons on the touch screen 56, the liquid metal 9, which is solid at room temperature, is heated by electricity. The liquid metal 9 becomes liquid, filling all the microscopic gaps at the mouth of the test tube, forming an absolutely airtight state. After the power is turned off and the liquid metal 9 returns to a solid state, locking the seal. Close the lid 3 and lock it with the latch 58.

[0068] (2) Sealing and negative pressure establishment: After the box cover 3 is closed, the controller 32 first controls the first solenoid valve 39 to close and the second solenoid valve 42 to open, and then starts the air pump 35.

[0069] Air pump 35 extracts air from the test tube storage space and inflates the sealing airbag 44 through exhaust pipe 38. After the airbag inflates, it tightly presses against the joint between the box body and the lid, forming the first active high-strength seal. At the same time, it creates negative pressure inside the test tube storage space.

[0070] After the airbag is inflated to the preset pressure, the controller 32 closes the second solenoid valve 42 and keeps the air pump 35 running, while simultaneously opening the first solenoid valve 39. The air pump begins to continuously extract air from the storage space and discharge it through the filter screen of the exhaust port 40, creating a relatively stable negative pressure environment in the test tube storage space.

[0071] The negative pressure environment inside the test tube storage space constitutes a second layer of protection. Even if a leak occurs inside the chamber 1, outside air will flow inward, effectively preventing harmful substances from leaking out. The second pressure sensor 46 monitors and provides feedback on the negative pressure value of the chamber 1 in real time.

[0072] (3) Environmental maintenance and monitoring: Temperature control system: Temperature and humidity sensor 47 monitors environmental data in real time. Controller 32 controls the operation of semiconductor cooling chip 30 according to the settings, and in conjunction with ventilation fan 18 to drive cold air circulation, so that the temperature inside the chamber is uniformly and stably maintained within the low temperature range required for the samples. Ice packs 24 in the cold source storage box serve as backup or auxiliary cold sources.

[0073] (4) Status monitoring:

[0074] Pipe-level monitoring: The first pressure sensor 12 on each plug 7 monitors the internal pressure of the test tube in real time. Once the internal pressure of a test tube 6 is abnormal (such as due to rupture or gas production), the controller 32 can immediately locate the specific test tube.

[0075] Box-level monitoring: A three-axis accelerometer 48 records abnormal events such as impacts and tipping during transportation. An electronic tag 10 stores sample information for easy identification and traceability. This information is transmitted to a touch screen 56 via the controller 32 for easy observation.

[0076] (5) Disinfection and Leak Absorption: In the event of a leak, the controller can activate the plasma array 33 to sterilize the air in the test tube storage space. At the same time, all or some of the fifth solenoid valves 54 are opened. The positive pressure pre-charged inside the storage box 49 rapidly sprays out powdered superabsorbent polymer 50, covering the leak area, instantly absorbing the liquid and solidifying it into a gel to prevent the liquid from flowing and spreading.

[0077] (6) Issue an alarm: When the system determines that a leak or severe impact has occurred based on the data from the first pressure sensor, the second pressure sensor or the triaxial acceleration sensor, the controller 32 controls the warning light 57 to issue a leak alarm and notify relevant personnel.

[0078] (7) Unpacking and maintenance: After transportation, the controller 32 controls the third solenoid valve 45 to open, releasing the gas in the sealed airbag 44 into the storage space. The airbag contracts, releasing part of the negative pressure in the box 1, and the locking force of the box lid is weakened, making it easier to open the box normally. New superabsorbent polymer 50 can be added to the storage box 49 through the feed pipe 51 and the fourth solenoid valve 53.

[0079] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims and not by the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A smart sealed transport device for biochemical samples, characterized in that: It includes a box body (1) with an opening at the top and a box cover (3) on the top of the box body (1). The box body (1) is provided with a vertically arranged first partition (2). The first partition (2) divides the interior of the box body (1) into two independent test tube storage spaces and a power supply space. A power supply (29) is installed in the power supply space. The test tube storage space is equipped with a detachable test tube rack (5), and a number of test tubes (6) that can be picked up and placed are installed on the test tube rack (5). The top of the test tube (6) is equipped with a detachable plug (7). The test tube rack (5) is equipped with a number of rotatable pressure plates (15). The pressure plates (15) are used to press on the top edge of the plug (7). The test tube rack (5) is equipped with a ventilation hole structure that is open from top to bottom. An annular groove is provided on the side wall of the plug (7), and an electrode pin (8) is provided on the inner wall of the annular groove. The annular groove is filled with liquid metal (9) that is electrically connected to the electrode pin (8). A flexible isolation film for sealing is provided at the opening of the annular groove. One side of the flexible isolation film is in contact with the liquid metal (9), and the other side of the flexible isolation film is in contact with the inner wall of the test tube (6). A circuit board (11) is provided on the top of the plug (7). The circuit board (11) is electrically connected to the electrode pin (8) and the circuit board (11) is electrically connected to the controller (32). When the electrode pin (8) heats the liquid metal (9) which is solid at room temperature, the liquid metal (9) can become liquid and fill the micro gap at the mouth of the test tube (6) to form an airtight state. After the power is turned off and the liquid metal (9) is cooled, it can return to a solid state to lock the sealed state. A second partition (31) is fixedly provided on the inner side wall of the box cover (3). A gap is left between the second partition (31) and the top of the box cover (3). A controller (32) is provided on the top of the second partition (31). The controller (32) is electrically connected to the power supply (29). A plasma array (33) is provided at the bottom of the second partition (31). The plasma array (33) is electrically connected to the controller (32). A storage box (49) is fixedly installed on the inner wall of the test tube storage space. The storage box (49) is located below the test tube rack (5). The storage box (49) contains powdered superabsorbent polymer (50). The bottom of the storage box (49) is provided with a discharge pipe. A fifth solenoid valve (54) is provided on the discharge pipe. The fifth solenoid valve (54) is connected to the controller (32). A temperature and humidity sensor (47) and a triaxial accelerometer (48) are installed on the inner wall of the test tube storage space. Both the temperature and humidity sensor (47) and the triaxial accelerometer (48) are connected to the controller (32) in communication. The side wall of the box (1) is provided with a slot that communicates with the test tube storage space. A cold source storage box that extends into the test tube storage space is inserted into the slot. An ice pack (24) is stored in the cold source storage box. A baffle (26) is fixed at the end of the cold source storage box. The area of ​​the baffle (26) is larger than the area of ​​the slot. The baffle (26) is detachably connected to the side wall of the box (1).

2. The intelligent sealed transport device for biochemical samples as described in claim 1, characterized in that: The bottom of the second partition (31) is fixed with an elastic sealing gasket (34), which is pressed against the top of the first partition (2). The side of the first partition (2) facing the test tube storage space is provided with a semiconductor cooling chip (30), which is located above the test tube rack (5). The semiconductor cooling chip (30) is connected to the controller (32).

3. The intelligent sealed transport device for biochemical samples as described in claim 2, characterized in that: The ventilation structure includes a first ventilation hole (16) and a second ventilation hole (17). The first ventilation hole (16) is located on the outside of the test tube (6), and the second ventilation hole (17) is located between adjacent test tubes (6). A ventilation fan (18) is provided on the top of the second ventilation hole (17). The airflow direction of the ventilation fan (18) is from top to bottom. The ventilation fan (18) is connected to the controller (32) for control.

4. The intelligent sealed transport device for biochemical samples as described in claim 1, characterized in that: The top of the second partition (31) is equipped with an air pump (35), which is connected to the controller (32). The air inlet of the air pump (35) is connected to one end of the suction pipe (36), and the other end of the suction pipe (36) passes through the second partition (31) and communicates with the test tube storage space. The suction pipe (36) is equipped with a first one-way valve (37). The air outlet of the air pump (35) is connected to one end of the exhaust pipe (38), and the other end of the exhaust pipe (38) is connected to the bottom of the exhaust port (40). The exhaust port (40) is embedded in the top of the box cover (3), and a filter structure is provided inside the exhaust port (40). A second pressure sensor (46) is provided on the inner wall of the test tube storage space, and the second pressure sensor (46) is connected to the controller (32) in communication.

5. The intelligent sealed transport device for biochemical samples as described in claim 4, characterized in that: The bottom of the second partition (31) is fixed with a circumferential annular groove plate (43). The vertical section of the annular groove plate (43) is an L-shaped structure. The side of the annular groove plate (43) facing the box body (1) is provided with an annular mounting groove. A sealing airbag (44) is installed in the mounting groove. The side of the sealing airbag (44) away from the annular groove plate (43) can be fully covered and attached to the joint between the box body (1) and the box cover (3). One end of the sealing airbag (44) is connected to the inflation tube (41), and the other end of the inflation tube (41) passes through the second partition (31) and is connected to the exhaust tube (38). The inflation tube (41) is equipped with a second solenoid valve (42), and the exhaust tube (38) is equipped with a first solenoid valve (39). The first solenoid valve (39) is located between the exhaust port (40) and the connection node between the inflation tube (41) and the exhaust tube (38). The sealing airbag (44) is connected to one end of the venting tube, and the other end of the venting tube passes through the annular groove plate (43) and is connected to the test tube storage space. The venting tube is equipped with a third solenoid valve (45). The first solenoid valve (39), the second solenoid valve (42), and the third solenoid valve (45) are respectively connected to the controller (32) for control.

6. The intelligent sealed transport device for biochemical samples as described in claim 1, characterized in that: The storage box (49) is an annular box structure surrounding the test tube (6), and the bottom of the storage box (49) is provided with multiple discharge pipes at equal intervals along its circumference. Each discharge pipe is provided with a fifth solenoid valve (54). All the fifth solenoid valves (54) are connected in series and then connected to the controller (32) for control. The upper part of the storage box (49) is connected to the feed pipe (51), and the feed pipe (51) is equipped with a second check valve (52) and a fourth solenoid valve (53). The second check valve (52) is located between the fourth solenoid valve (53) and the storage box (49), and the fourth solenoid valve (53) is connected to the controller (32). The storage box (49) is filled with pressurized gas so that the internal pressure of the storage box (49) is greater than the gas pressure in the test tube storage space.

7. The intelligent sealed transport device for biochemical samples as described in claim 1, characterized in that: The bottom of the plug (7) is embedded with a first pressure sensor (12) for monitoring the internal pressure of the test tube (6), and the top of the plug (7) is provided with an electronic tag (10). The electronic tag (10) and the first pressure sensor (12) are both connected to the circuit board (11).

8. The intelligent sealed transport device for biochemical samples as described in claim 1, characterized in that: The test tube storage space is provided with a support plate (19). One end of the support plate (19) is fixedly connected to the first partition (2). Several elastic bases (20) are fixedly provided on the top of the support plate (19). The top of the base (20) is provided with a slot that fits the lower end of the test tube (6). The lower end of the test tube (6) is inserted into the slot.

9. The intelligent sealed transport device for biochemical samples as described in claim 1, characterized in that: The top of the box cover (3) is equipped with a touch screen (56) and a warning light (57), both of which are connected to the controller (32); A transparent observation window (59) is provided on the side wall of the box (1), and the observation window (59) corresponds to the inside and outside of the test tube (6).

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