Seed treatment suspending agent containing flurobixafen and tebuconazole

Abstract

The invention provides a seed treatment suspending agent containing chlorine fluorine bixafen and tebuconazole as well as a preparation method and application of the seed treatment suspending agent. The seed treatment suspending agent is prepared from the following raw materials: a flurobixafen active compound, a tebuconazole active compound, a dispersing agent, a wetting dispersing agent, a thickening agent, a preservative, an anti-freezing agent, a film-forming agent, warning coloration, a de-foaming agent and de-ionized water. The seed treatment suspending agent containing flurobixafen and tebuconazole prepared by the invention is good in suspending performance, low-temperature stability and heat storage stability, reduces the application amount and the harm to the environment, delays the generation of drug resistance of germs, and is safe to crops.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of seed treatment suspending agent, and particularly relates to a seed treatment suspending agent containing bixafen and tebuconazole, and a preparation method and application thereof. BACKGROUND

[0002] Bixafen is a diphenyl pyrazole amide fungicide developed by Bayer Crop Science in 2003, belonging to the succinate dehydrogenase inhibitor (SDHI) class. The chemical name is N-[2-(3,4-dichlorophenyl)-4-fluorophenyl]-3-(difluoromethyl)-1-methylpyrazole-4-formamide, and the molecular formula is C18H12Cl2F3N3O. The fungicide mainly acts on complex II of the mitochondrial respiratory electron transport chain of pathogenic fungi, i.e. succinate dehydrogenase. By inhibiting the function of mitochondria, the energy metabolism pathway of pathogenic fungi is hindered, thereby effectively inhibiting the growth of pathogenic fungi and ultimately leading to the death of pathogenic fungi. It is widely used for preventing and treating leaf spot and leaf rust in grain fields, and also shows excellent control effect on various plant diseases caused by ascomycetes, basidiomycetes and deuteromycetes such as powdery mildew and gray mold. It has strong systemicity, broad-spectrum applicability, and dual protection and treatment effects; bixafen can also induce physiological changes in wheat plants, such as synchronous heading, increased green leaf area, and delayed plant senescence, thereby improving the physiological activity of the ear during the grain filling period and increasing the yield. However, long-term single use can induce target site mutation (such as G143A mutation) of pathogenic fungi, leading to rapid development of drug resistance. The Chinese patent of bixafen has expired in 2023 (WO2003070705A1), and the cost of imitation development is reduced, providing economic feasibility for the preparation of a compound preparation.

[0003] Tebuconazole is an organic compound with the molecular formula C16H22ClN3O, which is a highly effective, broad-spectrum, systemic triazole fungicide with protection, treatment and eradication functions, and has a wide fungicidal spectrum and a long effective period. Like all triazole fungicides, tebuconazole can inhibit the biosynthesis of ergosterol in fungi. Tebuconazole is used as a seed treatment agent and foliar spray in the world, and has a wide fungicidal spectrum, high activity and long effective period. Tebuconazole is mainly used for preventing and treating various fungal diseases on wheat, rice, peanuts, vegetables, bananas, apples, pears and corn sorghum crops, and can prevent early infection diseases and improve crop stress resistance. It has been registered and widely used in more than 60 crops in more than 50 countries around the world.

[0004] The key period for the prevention and control of wheat stem base rot is concentrated in the stage from autumn sowing to wintering, and seed coating or seed dressing treatment is an effective means to block the infection of the pathogen. Seed treatment suspension (FS) as a kind of liquid preparation, through the synergistic effect of physical isolation and chemical active ingredients, realizes precise application, long-acting slow release and environmental friendly advantages. At present, there are still three technical bottlenecks for this kind of preparation: first, the insufficient suspension stability leads to stratification or precipitation of the effective components, affecting the uniformity of drug effect; second, crystallization failure under low temperature conditions; third, the active ingredient is accelerated to degrade in high temperature environment. These defects directly restrict the field control effect and the yield improvement of crops.

[0005] Chinese invention patent CN119423092A discloses a fungicidal composition of chlorfluazuron and tebuconazole, which mentions that the composition can be prepared into a suspension agent and the like, but does not disclose any specific formulation of the dosage form.

[0006] In view of the above problems, it has significant potential to develop a new FS preparation based on the combination of chlorfluazuron (SDHI) and tebuconazole (triazole). The combination can prevent and control ascomycetes, basidiomycetes and soil-borne diseases through the dual action mechanism of inhibiting the mitochondrial function of pathogenic bacteria and destroying the cell membrane structure. However, it is still necessary to balance the concentration of the preparation and the germination safety, and continuously optimize the combination scheme to cope with the resistance risk, so as to become an efficient and sustainable disease prevention and control solution in modern green agriculture. SUMMARY

[0007] In order to solve the above technical problems, the present application provides a seed treatment suspension containing chlorfluazuron and tebuconazole, wherein the weight ratio of chlorfluazuron to tebuconazole is 1-40: 40-1, in a preferred scheme, the weight ratio of chlorfluazuron to tebuconazole is 1-30: 30-1, and in order to make the effect more obvious, the weight ratio of the two can be further preferably 10-15: 20-30.

[0008] The raw material composition includes, by mass percentage: chlorfluazuron technical material 1-40%, tebuconazole technical material 1-40%, dispersing agent 3-8%, wet dispersing agent 2-5%, thickening agent 0.2-3%, preservative 0.1-1%, antifreeze 3-6%, film forming agent 0.1-3%, warning color 0.5-10%, defoaming agent 0.1-1%, and the balance is deionized water to make up to 100%.

[0009] The dispersing agent is selected from one or more of nonylphenol polyoxyethylene, glycerol fatty acid polyoxyethylene, sodium salt of cresol-formaldehyde condensate, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, alkyl naphthalene sulfonate, naphthalene sulfonate formaldehyde condensate, sodium lignosulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, lignosulfonate, sodium p-hydroxyphenyl lignosulfonate, fatty alcohol polyoxyethylene ether sulfate, alkyl phenol polyoxyethylene ether formaldehyde condensate, dodecyl trimethyl ammonium salt, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty amido benzene sulfonic acid, p-methoxy fatty amido benzene sulfonic acid salt, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, polyoxyethylene sorbitan fatty acid ester.

[0010] The wetting dispersing agent is selected from one or more of Morwet D-360 / D-390, Atlox™ 4913, EO-PO block copolymer.

[0011] The thickening agent is selected from one or more of modified carboxypropyl cellulose, gum arabic, animal glue, pectin, xanthan gum, methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, magnesium aluminum silicate, sodium alginate, polyethylene glycol, polyvinyl pyrrolidone, polyacrylamide, sodium polyacrylate.

[0012] The preservative is selected from one or more of BIT, formaldehyde, sodium benzoate, isothiazolinones, carboxin, polyformaldehyde, sodium citrate, sodium salicylate, potassium sorbate.

[0013] The antifreezing agent is selected from one or more of ethylene glycol, propylene glycol, glycerol, inorganic salt, polyethylene glycol, sorbitol.

[0014] The film forming agent is selected from one or more of modified carboxypropyl cellulose, polyvinyl alcohol, acrylic emulsion, gum arabic, animal glue, pectin, xanthan gum, methyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, sodium alginate, polyethylene glycol, polyvinyl pyrrolidone, polyacrylamide, sodium polyacrylate.

[0015] The warning color is selected from one or more of acid scarlet, rose essence, red paste, brilliant blue, methyl violet, pearl powder.

[0016] The antifoaming agent is selected from one or more of silicone, butyl phosphate, organosilicon, isobutyl phosphate, n-octanol, polyether antifoaming agent, high carbon alcohol, tributyl phosphate, polysiloxane antifoaming agent.

[0017] Preferably, the dispersing agent is sodium salt of cresol-formaldehyde condensate, and the wetting dispersing agent is EO-PO block copolymer. The ratio of the two is 3:2.

[0018] By adopting the technical scheme, the seed treatment suspending agent of the fluoroimid and the tebuconazole prepared by adopting specific raw materials and a specific ratio has good seed treatment effect, good suspending performance, excellent low-temperature stability and thermal storage stability. The seed treatment suspending agent prepared by the application can maintain stability under low-temperature conditions, prevent freezing or precipitation and ensure effective use in a cold environment. The seed treatment suspending agent can also maintain stability under high-temperature conditions, avoid decomposition or failure of the active ingredients and ensure long-term storage and use effect.

[0019] The application combines the two fungicides with different mechanisms of action, i.e., the fluoroimid and the tebuconazole, can provide more comprehensive seed protection, expand the fungicidal spectrum, resist various pathogenic bacteria, improve the disease resistance of seeds and protect the seeds from disease invasion. The addition of a proper amount of wetting agent, dispersing agent and film-forming agent can form a uniform and stable suspending liquid, ensure uniform distribution of the active ingredients on the surface of the seeds and improve the treatment effect.

[0020] In another aspect, the application provides a preparation method of the seed treatment suspending agent containing the fluoroimid and the tebuconazole. S1, the wetting dispersing agent, the dispersing agent and the defoaming agent are weighed and added to the remaining deionized water under shearing, and then the fluoroimid and the tebuconazole technical material are added after shearing for 5 minutes, and shearing is continued for 5 minutes; S2, the antifreeze agent and the thickening agent 1 are weighed and stirred to form a dispersion of the thickening agent 1 in the antifreeze agent; S3, the thickening agent 2, the preservative and the mixture obtained in S1 and S2 are mixed, and shearing is continued for 15 minutes to obtain a suspending slurry, and the thickening agent 2 is different from the thickening agent 1; S4, after the cooling device is started, the slurry obtained in S3 is sand ground, and the temperature of the first-stage sand grinding is ensured to be not more than 30 DEG C, and the temperature of the second-stage and third-stage sand grinding is ensured to be not more than 35 DEG C.

[0021] S5, the suspending slurry after sand grinding in S4, the film-forming agent and the warning color are added to a mixing kettle, shearing is continued for 20 minutes until the particle fineness reaches D98 < 5 μm, and a uniform dispersion is obtained, and then each index is detected, and after the indexes are qualified, the fluoroimid and the tebuconazole seed treatment suspending agent are obtained.

[0022] Preferably, the thickening agent in S2 is xanthan gum, and the antifreeze agent is ethylene glycol. The xanthan gum is dispersed in the ethylene glycol in advance.

[0023] In a third aspect, the application provides application of the seed treatment suspending agent containing the fluoroimid and the tebuconazole in the prevention and treatment of wheat basal stem rot.

[0024] By adopting the technical scheme, the seed treatment suspension agent of the application takes chlorophyrifam and tebuconazole as active ingredients, and exhibits remarkable effects on the control of stem base rot of wheat and other crops. The preparation can efficiently inhibit the growth of pathogenic bacteria and effectively control the occurrence of diseases through the synergistic effect of the two active ingredients. Meanwhile, the suspension agent can promote the development of crop roots and provide protection for the healthy growth of plants. The technical scheme has the characteristics of good control effect, safe use, and the like, and has important application value in agricultural production.

[0025] Preferably, the seed treatment suspension agent is used for coating treatment of the wheat seeds.

[0026] By adopting the technical scheme, the seed treatment suspension agent of the application adopts the seed coating treatment method, can protect seeds, promote seed germination and growth, and improve the stress resistance and yield of seeds. Seed coating is beneficial to the effective release and action of active ingredients and other auxiliary ingredients, can also prevent the invasion of pathogenic bacteria and pests, and improve the disease resistance and insect resistance of seeds. The use method of coating treatment is suitable for various crops.

[0027] In summary, the application has the following at least one beneficial technical effect: 1. The chlorophyrifam and tebuconazole mixed in the application have obvious synergistic effect compared with single agent, the drug efficacy is more durable, and the control effect on crop diseases is significantly improved. Meanwhile, the application amount is reduced, the control spectrum is widened, the effect is fast, the duration is longer, and the harm to the environment is reduced.

[0028] 2. The suspension agent of the application complexed with the sodium salt of cresol-formaldehyde concentrate and EO-PO block copolymer, takes into account the electrostatic repulsion and steric hindrance effect, improves the stability of the suspension system, and balances the market and production cost.

[0029] 3. The two active ingredients in the application greatly delay the generation of drug resistance of pathogenic bacteria, reduce the risk of drug damage, and are safe to crops. DETAILED DESCRIPTION

[0030] In order to more clearly illustrate the specific embodiments of the application or the technical scheme in the prior art, the drawings needed in the following specific embodiments or prior art description will be briefly introduced. Obviously, the drawings in the following description are some embodiments of the application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0031] Fig. 1 is a production process flow chart of the seed treatment suspension agent of examples 1, 2, 3 and 4. DETAILED DESCRIPTION

[0032] The application will be further described in connection with the following examples, but the application is not limited thereto.

[0033] The various reagents used in the following examples of the application can be obtained commercially or prepared in-house. The chlorofluorobenzylpyrimidinylamine technical material used in the examples was purchased from Shandong Weifang Runfeng Chemical Co., Ltd., and the technical material of tebuconazole was purchased from Jiangsu Long Deng Chemical Co., Ltd. In addition, unless otherwise specified, the percentages described in the following examples are mass percentages.

[0034] Example 1: 32% chlorofluorobenzylpyrimidinylamine·tebuconazole (10%+21%) seed treatment suspension concentrate S1, weigh 2% EO-PO block copolymer, 3% cresol-formaldehyde sodium salt concentrate, 0.2% isobutyl phosphate, and add the rest of the deionized water under shearing conditions, after shearing for 5 min, add 10% chlorofluorobenzylpyrimidinylamine and 21% tebuconazole technical material, and continue to shear for 5 min; S2, weigh 4% ethylene glycol and 0.2% xanthan gum, and stir to form a xanthan gum dispersion in ethylene glycol; S3, mix 1% magnesium aluminum silicate, 0.1% sodium benzoate with the mixture obtained in S1, S2, and continue to shear for 15 min to obtain a suspension slurry; S4, after starting the cooling device, sand mill the slurry obtained in S3, and ensure that the temperature of the first stage of sand milling is not more than 30°C, and the temperature of the second and third stages of sand milling is not more than 35°C.

[0035] S5, add the suspension slurry after sand milling in S4, 0.5% sodium carboxymethyl cellulose, and 0.03% acid red to a mixing kettle, shear for 20 min until the particle fineness reaches D98<5μm, and then detect the indicators after the formation of a uniform dispersion, and after passing the quality inspection, the chlorofluorobenzylpyrimidinylamine·tebuconazole seed treatment suspension concentrate is obtained.

[0036] Example 2: 37.5% chlorofluorobenzylpyrimidinylamine·tebuconazole (12%+25.5%) seed treatment suspension concentrate S1, weigh 2% EO-PO block copolymer, 3% cresol-formaldehyde sodium salt concentrate, 0.2% silicone, and add the rest of the deionized water under shearing conditions, after shearing for 5 min, add 12% chlorofluorobenzylpyrimidinylamine and 25.5% tebuconazole technical material, and continue to shear for 5 min; S2, weigh 4% ethylene glycol and 0.13% xanthan gum, and stir to form a xanthan gum dispersion in ethylene glycol; S3, mix 0.8% magnesium aluminum silicate, 0.1% BIT with the mixture obtained in S1, S2, and continue to shear for 15 min to obtain a suspension slurry; S4, after starting the cooling device, the slurry obtained in S3 is sand ground, and the sand grinding temperature is ensured to be not more than 30 DEG C in the first stage, and not more than 35 DEG C in the second and third stages.

[0037] S5, the sand ground slurry in S4, 0.6% modified carboxypropyl cellulose and 6% red color paste are added into a mixing kettle, and sheared for 20 min until the particle fineness reaches D98 < 5 μm, and then each index is detected after the uniform dispersion is obtained, and the chlorofluorobiphenyl pyrimidine * tebuconazole seed treatment suspending agent product is obtained after the qualified product is packed.

[0038] Example 3: 40.5% chlorofluorobiphenyl pyrimidine * tebuconazole (10.5% + 30%) seed treatment suspending agent S1, 3% EO-PO block copolymer, 4.5% cresol-formaldehyde sodium salt concentrate, 0.3% polysiloxane are weighed, and the rest of deionized water is added under shearing, 10.5% chlorofluorobiphenyl pyrimidine and 30% tebuconazole are added after shearing for 5 min, and shearing is continued for 5 min; S2, 5% ethylene glycol and 0.25% xanthan gum are weighed, and a xanthan gum dispersion in ethylene glycol is prepared by stirring; S3, 0.6% sodium alginate and 0.1% BIT are weighed and mixed with the mixture obtained in S1 and S2, and shearing is continued for 15 min, and then a slurry is obtained; S4, after starting the cooling device, the slurry obtained in S3 is sand ground, and the sand grinding temperature is ensured to be not more than 30 DEG C in the first stage, and not more than 35 DEG C in the second and third stages.

[0039] S5, the sand ground slurry in S4, 0.6% modified carboxypropyl cellulose and 6% red color paste are added into a mixing kettle, and sheared for 20 min until the particle fineness reaches D98 < 5 μm, and then each index is detected after the uniform dispersion is obtained, and the chlorofluorobiphenyl pyrimidine * tebuconazole seed treatment suspending agent product is obtained after the qualified product is packed.

[0040] Example 4: 44% chlorofluorobiphenyl pyrimidine * tebuconazole (14% + 30%) seed treatment suspending agent S1, 3% EO-PO block copolymer, 4.5% cresol-formaldehyde sodium salt concentrate, 0.5% butyl phosphate are weighed, and the rest of deionized water is added under shearing, 14% chlorofluorobiphenyl pyrimidine and 30% tebuconazole are added after shearing for 5 min, and shearing is continued for 5 min; S2, 3% ethylene glycol and 0.3% xanthan gum are weighed, and a xanthan gum dispersion in ethylene glycol is prepared by stirring; S3, 0.9% gum arabic and 0.15% formaldehyde are weighed and mixed with the mixture obtained in S1 and S2, and shearing is continued for 15 min, and then a slurry is obtained; S4, after turning on the cooling device, the slurry obtained in S3 was sand ground, and the temperature of the first stage sand grinding was ensured to be not more than 30°C, and the temperature of the second and third stage sand grinding was ensured to be not more than 35°C.

[0041] S5, the sand ground slurry in S4, 0.7% sodium alginate and 0.05% methyl violet were added into a mixing kettle, and sheared for 20 min until the particle fineness reached D98<5μm, and then each index was detected after the uniform dispersion was obtained, and the chlorfluazuron·tebuconazole seed treatment suspension concentrate product was obtained after the qualified product was packaged.

[0042] Comparative Example 1 The difference between Comparative Example 1 and Example 2 is that the dispersant in Comparative Example 1 is naphthalene sulfonate formaldehyde condensate, and the wetting dispersant is Morwet D-360.

[0043] Comparative Example 2 The difference between Comparative Example 2 and Example 2 is that the active ingredient in Comparative Example 2 is replaced by an equal weight of chlorfluazuron technical material.

[0044] Comparative Example 3 The difference between Comparative Example 3 and Example 2 is that the preparation method in Comparative Example 3 is that all the raw materials are mixed in one step to prepare chlorfluazuron·tebuconazole seed treatment suspension concentrate.

[0045] Application Example 1 Test material: the test pathogen is Pseudocercosporella herpotrichoides (Berk.) Sacc. Fusarium pseudograminearum Pseudocercosporella herpotrichoides was obtained by isolation and purification from wheat with naturally occurring stem base rot in the field, and the strain was identified by morphology and pathogenicity and stored in an ultra-low temperature refrigerator for standby use.

[0046] Indoor combined toxicity effect of chlorfluazuron and tebuconazole on Pseudocercosporella herpotrichoides Test method: according to the method of mycelial growth rate in the "Pesticide indoor biological determination test standard NY / T 1156.6-2006, part 6: mixed fungicide joint action determination", the pesticide was prepared into 5000 mg / L mother liquor, then a certain amount was mixed according to the predetermined proportion in table 1, and 5 concentration gradients were prepared with 1% Tween 80 aqueous solution, then added to PDA medium at 45-50℃, the volume ratio of drug solution to medium was 1:9, mixed uniformly and poured into sterilized culture dish, cooled to form toxic medium, each concentration was repeated 5 times. Use 1% Tween 80 aqueous solution as control. Then, under sterile conditions, the pathogenic fungus was inoculated into the central part of the toxic medium. The culture dishes were placed in a culture box with temperature of 25℃ and humidity of 90%. When the colony radius on the control plate was about 2 / 3 of the plate radius, the diameter of each treatment colony was measured by cross method, and the percentage of mycelial growth inhibition of each treatment was calculated. Through linear regression analysis between the probability value of inhibition rate and the logarithmic value of serial concentration, the EC 50 .

[0047] According to the Wadley method to evaluate the interaction of mixed agents, the calculation formula is as follows: Mycelial growth inhibition rate (%) = (control colony diameter - treatment colony diameter) / (control colony diameter - colony cake diameter) x 100% EC 50 (theoretical value) = (P A + P B ) / (P A / EC 50 A + P B / EC 50 B) SR = EC 50 (theoretical value) / EC 50 (measured value) Wherein, P A is the percentage content of agent A in the mixed agent, P B is the percentage content of agent B in the mixed agent.

[0048] SR≤0.5 indicates antagonism, 0.5

[0049] As can be seen from table 1, the mixed preparation of fluazinam and tebuconazole has good fungicidal effect on pseudocercosporella herpotrichoides. When the mass ratio is in the range of 10-15:20-30, the synergistic coefficient SR is greater than 1.5, showing synergistic effect. It is proved that the mixed preparation of fluazinam and tebuconazole can improve the control effect on pseudocercosporella herpotrichoides.

[0050] Table 1 In vitro combined toxicity of chlorfluazuron and tebuconazole to Fusarium pseudograminearum

[0051] Note: X value is converted by taking the logarithm of the base 10, and y value is the probability value.

[0052] Application Example 2 The pH value, suspensibility, low-temperature stability and heat storage stability of the seed treatment suspension containing chlorfluazuron and tebuconazole were detected according to GB / T 17768-1999 "Standard Writing Specification for Suspension Concentrate Products".

[0053] Stem base rot control effect detection: The crop seeds were coated with the seed treatment suspension, and the blank group was not treated with the seed treatment suspension. The soil was randomly taken from the field, sterilized in a 105°C oven overnight, and then taken out and moistened with deionized water to match the field humidity. The indoor cultured stem base rot fungus was mixed with the moist soil to perform soil inoculation treatment to obtain stem base rot fungus infected soil. Then the seed treatment suspension coated seeds and the seeds of the blank group were sown, and each treatment was set up in three replicates to take the average value. The control effect of wheat stem base rot during the growth period was calculated. The stem base rot fungus was Fusarium pseudograminearum. Fusarium pseudograminearum

[0054] Control effect (%) = [(disease incidence of the blank group - disease incidence of the seed treatment suspension treated group) / disease incidence of the blank group] x 100%; The seed treatment suspensions prepared in Examples 1-4 and Comparative Examples 1-3 were detected for suspensibility, coating shedding rate, low-temperature stability and heat storage stability, and the seed treatment suspension coated wheat seeds were detected for stem base rot control effect. The detection results are shown in Table 2.

[0055] From the detection results in Table 2, it can be seen that the seed treatment suspension containing chlorfluazuron and tebuconazole prepared in Examples 1-4 has high suspensibility, good suspensibility, good low-temperature stability and heat storage stability, and excellent control effect on wheat stem base rot after coating treatment on crop seeds.

[0056] The seed treatment suspension containing chlorfluazuron and tebuconazole prepared in Comparative Example 1 without adding cresol-formaldehyde sodium salt concentrate and EO-PO block copolymer has significantly decreased suspensibility, poor suspensibility, poor cold and heat storage stability, and significantly decreased control effect on wheat stem base rot.

[0057] The seed treatment suspension containing chlorfluazuron and tebuconazole prepared in Comparative Example 2 has qualified suspensibility and cold and heat storage stability, and significantly lower control effect on wheat stem base rot than Examples 1, 2, 3 and 4.

[0058] ​Comparative Example 3 was prepared by directly mixing one step without sub-step mixing, and the seed treatment suspension of the prepared chlorofluorobiphenyl pyriminostrobin·tebuconazole had poor suspensibility, unqualified film forming property, and lower control effect on wheat foot rot than Examples 1, 2, 3, and 4. The inventors speculate that the possible reason is that the active ingredients of the seed treatment suspension are not uniformly mixed, and the stability and uniformity are poor.

[0059] Table 2 Quality index detection of seed treatment suspension

[0060] The present application is not limited to the above examples, and based on the technical solutions disclosed in the present application, those skilled in the art can make some substitutions and modifications to some technical features without creative labor according to the disclosed technical content, and these substitutions and modifications are all within the protection scope of the present application.

Claims

1. A seed treatment suspension, characterized in that: By weight percentage, its raw material composition includes: 1-40% chlorofluorobifenpyroxen technical grade, 1-40% tebuconazole technical grade, 3-8% dispersant, 2-5% wetting and dispersing agent, 0.2-3% thickener, 0.1-1% preservative, 3-6% antifreeze, 0.1-3% film-forming agent, 0.5-10% warning color, 0.1-1% defoamer, and the balance being deionized water to make up to 100%. The mass ratio between the chlorofluorobifenpyroxen and tebuconazole is 1-40 : 40-1.

2. The seed treatment suspension according to claim 1, characterized in that: The weight ratio of chlorofluorobifenpyroxen to tebuconazole is 1-30 : 30-1.

3. The seed treatment suspension agent according to claim 2, characterized in that: The weight ratio of chlorofluorobifenpyroxen to tebuconazole is 10-15: 20-30.

4. A seed treatment suspension agent according to claims 1-3, characterized in that: The dispersant is selected from one or more of the following: nonylphenol polyoxyethylene ether, glycerol fatty acid polyoxyethylene ether, cresol-formaldehyde sodium salt concentrate, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, alkyl naphthalene sulfonate, naphthalene sulfonate formaldehyde condensate, sodium lignosulfonate, sodium naphthalene sulfonate formaldehyde condensate, lignosulfonate, p-hydroxyphenyl lignosulfonate sodium salt, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, dodecyl trimethylammonium salt, alkyl dimethyl benzylammonium salt, p-methoxy fatty amide benzene sulfonic acid, p-methoxy fatty amide benzene sulfonic acid, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, and polyoxyethylene sorbitan fatty acid ester. The wetting and dispersing agent is selected from one or more of Morwet D-360 / D-390, Atlox™ 4913, and EO-PO block copolymers; The thickener is selected from one or more of the following: modified carboxypropyl cellulose, gum arabic, animal glue, pectin, xanthan gum, methylcellulose, ethylcellulose, sodium carboxymethyl cellulose, magnesium aluminum silicate, sodium alginate, polyethylene glycol, polyvinylpyrrolidone, polyacrylamide, and sodium polyacrylate. The antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, inorganic salts, polyethylene glycol, and sorbitol.

5. The seed treatment suspension according to claim 4, characterized in that: The dispersant is a cresol-formaldehyde sodium salt concentrate, and the wetting and dispersing agent is an EO-PO block copolymer; wherein the weight ratio of the cresol-formaldehyde sodium salt concentrate and the EO-PO block copolymer is 3:2; The thickener is xanthan gum; The antifreeze agent is ethylene glycol, and xanthan gum and ethylene glycol are mixed beforehand and stirred to form a dispersion of xanthan gum in ethylene glycol.

6. A method for preparing a seed treatment suspension according to any one of claims 1-5, characterized in that, The preparation process includes the following steps: S1. Weigh out the wetting and dispersing agent, dispersant, and defoamer, and add them to the remaining deionized water under shearing conditions. After shearing for 5 minutes, add the technical grade of chlorpyrifos bifenthrin and tebuconazole, and continue shearing for 5 minutes. S2. Weigh out the antifreeze and thickener 1, and stir to form a dispersion of thickener 1 in the antifreeze; S3. Weigh out thickener 2, preservative and mix with the mixture obtained from S1 and S2, and continue shearing for 15 minutes to obtain a suspension slurry. The thickener 2 is different from the thickener 1. S4. After turning on the cooling device, the slurry obtained in S3 is sand-milled. During the sand-milling process, the temperature of the first-stage sand milling does not exceed 30℃, and the temperature of the second and third-stage sand milling does not exceed 35℃. S5. Add the suspended slurry after sand milling in S4, the film-forming agent, and the warning color to the mixing tank. Shear for 20 minutes until the particle fineness reaches D98<5μm and forms a uniform dispersion. Then test each index. After passing the test, package the product to obtain the finished product.

7. The application of a seed treatment suspension according to claims 1-5 in the prevention and control of crop diseases.

8. The application according to claim 7, characterized in that, The crop disease mentioned is wheat stem base rot.

Images