Herbal warming moxibustion warm paste and preparation method thereof

Abstract

The invention relates to the technical field of warming patches, in particular to a herbal warming moxibustion warming patch and a preparation method thereof.The herbal warming moxibustion warming patch is characterized in that a printed non-woven fabric, a heating layer, a herbal layer and a skin-friendly non-woven fabric are sequentially compounded from top to bottom to obtain a warming patch body, and when the warming patch is used, a self-adhesive moistening bag is attached to the warming patch body; the graphene non-woven fabric and the skin-friendly non-woven fabric are subjected to antibacterial finishing liquid modification treatment, so that the comfort and the safety of the warm paste are improved; treating the non-woven fabric by using vinyltriethoxysilane, and introducing double bonds; composite microcapsules, carboxylated chitosan, a penetrating agent, an initiator and deionized water are mixed to serve as antibacterial finishing liquid, the antibacterial durability of the warm paste is improved, the safety of the warm paste is greatly improved, and the service life of the warm paste is greatly prolonged.

Description

Technical Field

[0001] This invention relates to the field of heat patch technology, specifically a herbal moxibustion heat patch and its preparation method. Background Technology

[0002] In the field of modern health care, heat patches are widely popular as a convenient physical heat therapy tool due to their excellent effects on warming the uterus, stomach, and relieving pain. Traditional heat patches mainly utilize the principle of exothermic oxidation of iron powder, but their function is relatively limited and cannot achieve the combined effect of "medicinal moxibustion" in "moxibustion" therapy. In addition, ordinary heat patches are usually directly adhered to the skin with pressure-sensitive adhesive, which has insufficient antibacterial properties, and prolonged use may cause stuffiness, itching, or even allergies.

[0003] To improve the functionality and comfort of heat patches, herbal heat patches combining traditional Chinese medicine powder with heating elements have appeared on the market. However, most herbal heat patches are simply mixed, making it difficult for the effective medicinal ingredients to be released efficiently and evenly under heat and absorbed transdermally. At the same time, the textile materials used in most herbal heat patches that come into contact with the skin lack effective antibacterial treatment, easily becoming a breeding ground for bacteria in warm and humid environments, posing hygiene and safety risks. Summary of the Invention

[0004] The purpose of this invention is to provide a herbal moxibustion patch and its preparation method to solve the problems in the prior art.

[0005] To solve the above-mentioned technical problems, the present invention provides the following technical solution: A method for preparing a herbal moxibustion patch includes the following steps: S1: Grind and sieve the fruit wood vinegar powder, tourmaline, pearl powder, rhodiola rosea, dendrobium, honeysuckle, clove, alisma, and poria cocos, mix them evenly, and package them in graphene non-woven fabric. A self-adhesive sticker is placed on the graphene non-woven fabric to obtain a self-adhesive moisturizing pack. S2: Mix cedar extract, iron powder, carbon powder, sodium chloride, vermiculite, and water-absorbing resin while spraying water. Seal and place. After taking it out, wrap it in a breathable non-woven fabric, a middle non-woven fabric, and a non-woven fabric cover to obtain the heating layer. S3: Crush and sift saffron, chuanxiong, rhodiola rosea, dried mugwort leaves, dried ginger, angelica, cinnamon twig, clematis root, and evodia fruit, mix them evenly, and package them in skin-friendly non-woven fabric to obtain the herbal layer; S4: The printed non-woven fabric, heating layer, herbal layer and skin-friendly non-woven fabric are laminated from top to bottom to obtain the main body of the heat patch. When using, the self-adhesive moisturizing pack is attached to the main body of the heat patch to obtain a herbal moxibustion heat patch.

[0006] Furthermore, by weight, the self-adhesive moisturizing packet contains 5-10 parts fruitwood vinegar powder, 3-5 parts tourmaline, 1-3 parts pearl powder, 7-12 parts Rhodiola rosea, 2-4 parts Dendrobium, 1-3 parts honeysuckle, 8-10 parts clove, 1-3 parts Alisma plantago-aquatica, and 2-4 parts Poria cocos.

[0007] Furthermore, by mass, the heating layer contains 0.5-1 parts of cedar extract, 50-60 parts of iron powder, 9-13 parts of charcoal powder, 1-2 parts of sodium chloride, 4-6 parts of vermiculite, 2-4 parts of water-absorbing resin, and 22-28 parts of water.

[0008] Furthermore, the water is one of deionized water, purified water, or ultrapure water.

[0009] Furthermore, by mass fraction, the herbaceous layer contains 1-3 parts saffron, 1.8-2.2 parts Ligusticum chuanxiong, 1.6-2.6 parts Rhodiola rosea, 6-8 parts dried Artemisia argyi, 7-10 parts dried ginger, 1-2 parts Angelica sinensis, 11-15 parts cinnamon twig, 1-2 parts Clematis chinensis, and 0.5-1 part Evodia rutaecarpa.

[0010] Furthermore, by controlling the raw materials and proportions of the herbal moxibustion patch, its heating layer can maintain a constant temperature for more than 8 hours, and its herbal layer can help penetrate and diffuse fragrance.

[0011] Furthermore, a herbal moxibustion patch can be applied to waist patches, neck patches, knee patches, foot patches, eye patches, wrist patches, and acupoint patches.

[0012] Furthermore, when the herbal moxibustion warming patch is applied to the waist patch, double layers of elastic non-woven fabric are provided on both sides of the main body of the warming patch, and Velcro is provided at the end of each double layer of elastic non-woven fabric away from the main body of the warming patch, thus obtaining the finished product.

[0013] Furthermore, the graphene nonwoven fabric is ultrasonically cleaned in anhydrous ethanol, air-dried, transferred to a mixture of anhydrous ethanol, deionized water, and ammonia, vinyltriethoxysilane is added, stirred for 5-6 hours, removed and dried, and then transferred to an antibacterial finishing solution for padding and light treatment to obtain antibacterial graphene nonwoven fabric.

[0014] Furthermore, the skin-friendly nonwoven fabric is ultrasonically cleaned in anhydrous ethanol, air-dried, transferred to a mixture of anhydrous ethanol, deionized water, and ammonia, vinyltriethoxysilane is added, stirred for 5-6 hours, removed and dried, then transferred to an antibacterial finishing solution for padding and light treatment to obtain antibacterial skin-friendly nonwoven fabric.

[0015] Furthermore, the working conditions for the dip-rolling treatment are: two dips and two rolls, with a roll residue of 80-85%; the working conditions for the light treatment are: 365nm ultraviolet light irradiation for 1-2 minutes; the composition of the antibacterial finishing solution is: using deionized water as a solvent, containing 1-3g / L of composite microcapsules, 10-15g / L of carboxylated chitosan, 0.2g / L of penetrant, and 0.1g / L of initiator.

[0016] Furthermore, the preparation of the composite microcapsules includes the following steps: (1) Tea tree oil and cedarwood oil were blended at a mass ratio of 7:3 to obtain a compound essential oil; (2) Mix halloysite nanotubes, distilled water, nonionic surfactant and compound essential oil, stir in a water bath at 38-42℃ for 30-35 min, add styrene, ethyl acrylate and ethylene glycol dimethacrylate and mix, then add ammonium persulfate and ferric sulfate heptahydrate solution and continue stirring, add sodium thiosulfate and tert-butyl hydrogen peroxide, heat to 93-97℃ and keep warm for 1-2 h, filter, wash and dry to obtain microcapsules containing carboxyl groups; (3) Mix microcapsules containing carboxyl groups, deionized water, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, add amino acid ionic liquid containing double bonds and N,N-dimethylformamide, keep warm at 20-30℃ for 5-6 hours, centrifuge, wash and dry to obtain composite microcapsules.

[0017] Furthermore, the preparation of amino acid ionic liquids containing double bonds includes the following steps: Under nitrogen protection, 1-vinylimidazolium, 3-bromopropylaminohydrobromide, and dimethyl sulfoxide were mixed, heated to 75-80℃ and stirred for 22-24 h. Ethyl acetate and anhydrous ethanol were added to precipitate the mixture, which was then washed, allowed to stand, and dried to obtain 1-vinyl-3-aminopropylimidazolium bromide. 1-vinyl-3-aminopropylimidazolium bromide and deionized water were mixed and passed through an anion exchange resin to obtain a hydroxylated ionic liquid. L-phenylalanine and deionized water were mixed, and the hydroxylated ionic liquid was added. The mixture was stirred at 18-25℃ for 11-12 h and then rotary evaporated to obtain an amino acid ionic liquid containing double bonds.

[0018] Compared with the prior art, the beneficial effects of the present invention are: This invention provides a herbal moxibustion warming patch and its preparation method. By optimizing the ingredients and process, a herbal moxibustion warming patch that is antibacterial, comfortable, and safe is prepared, which significantly improves the problems of traditional warming patches such as single function, hygiene hazards, and poor applicability.

[0019] Traditional herbal heat packs often directly mix Chinese medicine with the heating element, which can easily lead to the destruction or ineffectiveness of the Chinese medicine at high temperatures. This invention physically separates and tightly bonds the "heating layer" and the "herbal layer" in the heat pack body. Through material design, the heating layer can continuously and stably provide uniform heat. This heat acts as a driving force to gently heat the herbal layer, allowing the Chinese medicine components in the herbal layer to be slowly and persistently activated and volatilized, penetrating the skin-friendly non-woven fabric and acting on the human body.

[0020] The herbal layer of this invention selects saffron, chuanxiong, angelica, and other Chinese medicinal ingredients with blood-activating effects as raw materials, and mugwort leaves, dried ginger, cinnamon twig, evodia, and other Chinese medicinal ingredients with warming and dispelling cold effects as raw materials. It adds clematis root to enhance the dehumidifying effect and rhodiola rosea to invigorate qi and activate blood. Through the ingredient ratio, it effectively improves the effects of dispelling cold and dampness, relieving pain, and eliminating fatigue.

[0021] This invention uses fruit vinegar powder, tourmaline, pearl powder, Rhodiola rosea, Dendrobium, honeysuckle, clove, Alisma plantago-aquatica, and Poria cocos powder as raw materials, and uses graphene non-woven fabric as packaging. A self-adhesive pack is provided on one side. When in use, the self-adhesive pack is attached to the center of the heat patch. The fruit vinegar powder, pearl powder, and other ingredients contained therein can first cleanse, moisturize, and pre-treat the skin, thereby improving the comfort and effectiveness of the heat patch.

[0022] To further improve the comfort and safety of the heat patch, the graphene nonwoven fabric or skin-friendly nonwoven fabric was modified with an antibacterial finishing liquid. First, the nonwoven fabric was cleaned, then treated with vinyltriethoxysilane to introduce double bonds and increase reactive sites. A mixture of composite microcapsules, carboxylated chitosan, a penetrant, an initiator, and deionized water was used as the antibacterial finishing liquid. By controlling the raw material ratio in the heating layer, heat was continuously provided for more than 8 hours with a stable temperature. Treatment of the graphene nonwoven fabric with the antibacterial finishing liquid further facilitated the uniform distribution of heat, thus providing a stable and uniform thermal guarantee for the diffusion of the herbal ingredients in the herbal layer. In this composite microcapsule, tea tree oil, with its broad-spectrum antibacterial properties, is combined with cedarwood oil, which also has antibacterial and aromatic properties, to serve as a natural antibacterial agent. To achieve slow release and improve the stability of the natural antibacterial agent, carboxyl-containing microcapsules were synthesized via emulsion polymerization. These microcapsules used polystyrene-ethyl acrylate as the shell material and the composite essential oil as the core material. Halloysite nanotubes were then inserted into the microcapsules as a supporting filler, thermal conductivity enhancer, and flame retardant, effectively enhancing the thermal stability of the microcapsules. To further improve the uniformity of the carboxyl-containing microcapsules on the nonwoven fabric surface, the reaction between carboxyl and amino groups was utilized... The surface of microcapsules containing carboxyl groups is grafted with amino acid ionic liquids containing double bonds. The amino acid ionic liquids containing double bonds are prepared with L-phenylalanine as an anion and 1-vinyl-3-aminopropylimidazolium as a cation, thereby further improving the biocompatibility of the microcapsules, improving the durability and broad-spectrum antibacterial activity. At the same time, polymerizable double bonds are introduced into the shell of the microcapsules, allowing them to participate in the subsequent UV curing crosslinking network and firmly crosslink onto the nonwoven fabric. Together with carboxylated chitosan, they form an antibacterial barrier, improving its antibacterial durability and enhancing the safety and service life of the heat pack. Attached Figure Description

[0023] Figure 1 This is a picture of the prepared herbal moxibustion warming patch applied to the waist. Detailed Implementation

[0024] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0025] Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection required by this invention.

[0026] The technical solution of the present invention will be further described in detail below with reference to specific embodiments. It should be understood that the following embodiments are only used to explain the present invention and are not intended to limit the present invention.

[0027] Example 1: A method for preparing a herbal moxibustion patch, comprising the following steps: S1: Grind and sieve the fruit wood vinegar powder, tourmaline, pearl powder, rhodiola rosea, dendrobium, honeysuckle, clove, alisma, and poria cocos, mix them evenly, and package them in graphene non-woven fabric. A self-adhesive sticker is placed on the graphene non-woven fabric to obtain a self-adhesive moisturizing pack. By weight, the self-adhesive moisturizing pack contains 5 parts fruit wood vinegar powder, 3 parts tourmaline, 1 part pearl powder, 7 parts Rhodiola rosea, 2 parts Dendrobium, 1 part honeysuckle, 8 parts clove, 1 part Alisma plantago-aquatica, and 2 parts Poria cocos. S2: Mix cedar extract, iron powder, carbon powder, sodium chloride, vermiculite and water-absorbing resin, spray deionized water while mixing, seal and place for 12 hours, take it out and wrap it in sequence with breathable non-woven fabric, middle non-woven fabric and non-woven fabric cover cloth to obtain the heating layer. By mass, the heating layer contains 0.5 parts cedar extract, 50 parts iron powder, 9 parts charcoal powder, 1 part sodium chloride, 4 parts vermiculite, 2 parts water-absorbing resin, and 22 parts water. S3: Crush and sift saffron, chuanxiong, rhodiola rosea, dried mugwort leaves, dried ginger, angelica, cinnamon twig, clematis root, and evodia fruit, mix them evenly, and package them in skin-friendly non-woven fabric to obtain the herbal layer; By mass fraction, the herbaceous layer contains 1 part saffron, 1.8 parts Ligusticum chuanxiong, 1.6 parts Rhodiola rosea, 6 parts dried Artemisia argyi, 7 parts dried ginger, 1 part Angelica sinensis, 11 parts Cinnamomum cassia, 1 part Clematis chinensis, and 0.5 parts Evodia rutaecarpa. S4: From top to bottom, the printed non-woven fabric, heating layer, herbal layer and skin-friendly non-woven fabric are combined to obtain the main body of the heat patch. When using, the self-adhesive moisturizing pack is attached to the main body of the heat patch to obtain a herbal moxibustion heat patch. 2g of graphene nonwoven fabric was ultrasonically cleaned in anhydrous ethanol for 20 minutes, air-dried, and then transferred to a mixture of 90mL anhydrous ethanol, 10mL deionized water, and 4mL ammonia. 1.2mL vinyltriethoxysilane was added, and the mixture was stirred for 5 hours. After drying, the fabric was transferred to an antibacterial finishing solution for padding and then light-treated to obtain antibacterial graphene nonwoven fabric. 2g of skin-friendly nonwoven fabric was ultrasonically cleaned in anhydrous ethanol for 20 minutes, air-dried, and then transferred to a mixture of 90mL anhydrous ethanol, 10mL deionized water, and 4mL ammonia. 1.2mL vinyltriethoxysilane was added, and the mixture was stirred for 5 hours. After drying, the fabric was transferred to an antibacterial finishing solution for padding and then light-treated to obtain antibacterial skin-friendly nonwoven fabric. The working conditions for the dip-and-roll treatment are: two dips and two rolls, with a roll residue of 80%; the working conditions for the light treatment are: 365nm ultraviolet light irradiation for 1 minute; the composition of the antibacterial finishing solution is: deionized water as solvent, containing 1g / L of composite microcapsules, 10g / L of carboxylated chitosan, 0.2g / L of penetrant, and 0.1g / L of initiator; The preparation of the composite microcapsules includes the following steps: (1) Tea tree oil and cedarwood oil were blended at a mass ratio of 7:3 to obtain a compound essential oil; (2) Mix 1g halloysite nanotubes, 90mL distilled water, 0.8g nonionic surfactant and 6g compound essential oil, stir in a 38℃ water bath for 35min, add 7g styrene, 7g ethyl acrylate and 4g ethylene glycol dimethacrylate and mix, then add 0.13g ammonium persulfate and 0.5mL ferric sulfate heptahydrate solution and continue stirring, add 0.13g sodium thiosulfate and 0.5mL tert-butyl hydrogen peroxide, heat to 93℃ and keep warm for 2h, filter, wash and dry to obtain microcapsules containing carboxyl groups; (3) Mix 4g of carboxyl-containing microcapsules, 120mL of deionized water, 2g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and 2g of N-hydroxysuccinimide, add 2.1g of amino acid ionic liquid containing double bonds and 30mL of N,N-dimethylformamide, keep warm at 20℃ for 6h, centrifuge, wash and dry to obtain composite microcapsules; The preparation of the amino acid ionic liquid containing double bonds includes the following steps: Under nitrogen protection, 0.5 mol of 1-vinylimidazolium, 0.5 mol of 3-bromopropylaminohydrobromide, and 100 mL of dimethyl sulfoxide were mixed, heated to 75 °C and stirred for 24 h. Ethyl acetate and anhydrous ethanol were added to precipitate the mixture, which was then washed, allowed to stand, and dried to obtain 1-vinyl-3-aminopropylimidazolium bromide. An equimolar amount of 1-vinyl-3-aminopropylimidazolium bromide and deionized water were mixed and passed through an anion exchange resin to obtain a hydroxylated ionic liquid. Then, 0.5 mol of L-phenylalanine and 80 mL of deionized water were mixed, and 0.5 mol of the hydroxylated ionic liquid was added. The mixture was stirred at 18 °C for 12 h and then rotary evaporated to obtain an amino acid ionic liquid containing double bonds.

[0028] Example 2: A method for preparing a herbal moxibustion patch, comprising the following steps: S1: Grind and sieve the fruit wood vinegar powder, tourmaline, pearl powder, rhodiola rosea, dendrobium, honeysuckle, clove, alisma, and poria cocos, mix them evenly, and package them in graphene non-woven fabric. A self-adhesive sticker is placed on the graphene non-woven fabric to obtain a self-adhesive moisturizing pack. By weight, the self-adhesive moisturizing pack contains 7 parts fruit wood vinegar powder, 4 parts tourmaline, 2 parts pearl powder, 10 parts Rhodiola rosea, 3 parts Dendrobium, 2 parts honeysuckle, 9 parts clove, 2 parts Alisma plantago-aquatica, and 3 parts Poria cocos. S2: Mix cedar extract, iron powder, carbon powder, sodium chloride, vermiculite and water-absorbing resin, spray deionized water while mixing, seal and place for 12 hours, take it out and wrap it in sequence with breathable non-woven fabric, middle non-woven fabric and non-woven fabric cover cloth to obtain the heating layer. By mass, the heating layer contains 0.8 parts of cedar extract, 55 parts of iron powder, 11 parts of charcoal powder, 1.5 parts of sodium chloride, 5 parts of vermiculite, 3 parts of water-absorbing resin, and 25 parts of water. S3: Crush and sift saffron, chuanxiong, rhodiola rosea, dried mugwort leaves, dried ginger, angelica, cinnamon twig, clematis root, and evodia fruit, mix them evenly, and package them in skin-friendly non-woven fabric to obtain the herbal layer; By mass fraction, the herbaceous layer contained 2 parts saffron, 2 parts Ligusticum chuanxiong, 2.2 parts Rhodiola rosea, 7 parts dried Artemisia argyi, 9 parts dried ginger, 1.5 parts Angelica sinensis, 13 parts Cinnamomum cassia, 1.5 parts Clematis chinensis, and 0.8 parts Evodia rutaecarpa. S4: From top to bottom, the printed non-woven fabric, heating layer, herbal layer and skin-friendly non-woven fabric are combined to obtain the main body of the heat patch. When using, the self-adhesive moisturizing pack is attached to the main body of the heat patch to obtain a herbal moxibustion heat patch. 2g of graphene nonwoven fabric was ultrasonically cleaned in anhydrous ethanol for 25 min, air-dried, and then transferred to a mixture of 90mL anhydrous ethanol, 10mL deionized water, and 4mL ammonia. 1.2mL vinyltriethoxysilane was added, and the mixture was stirred for 5.5h. After drying, the fabric was transferred to an antibacterial finishing solution for padding and then light-treated to obtain antibacterial graphene nonwoven fabric. 2g of skin-friendly nonwoven fabric was ultrasonically cleaned in anhydrous ethanol for 25 min, air-dried, and then transferred to a mixture of 90mL anhydrous ethanol, 10mL deionized water, and 4mL ammonia. 1.2mL vinyltriethoxysilane was added, and the mixture was stirred for 5.5h. After drying, the fabric was transferred to an antibacterial finishing solution for padding and then light-treated to obtain antibacterial skin-friendly nonwoven fabric. The working conditions for the dip-and-roll treatment are: two dips and two rolls, with a roll residue of 83%; the working conditions for the light treatment are: 365nm ultraviolet light irradiation for 1.5 min; the composition of the antibacterial finishing solution is: deionized water as solvent, containing 2g / L of composite microcapsules, 13g / L of carboxylated chitosan, 0.2g / L of penetrant, and 0.1g / L of initiator; The preparation of the composite microcapsules includes the following steps: (1) Tea tree oil and cedarwood oil were blended at a mass ratio of 7:3 to obtain a compound essential oil; (2) Mix 1g halloysite nanotubes, 90mL distilled water, 0.8g nonionic surfactant and 6g compound essential oil, stir in a 40℃ water bath for 33min, add 7g styrene, 7g ethyl acrylate and 4g ethylene glycol dimethacrylate and mix, then add 0.13g ammonium persulfate and 0.5mL ferric sulfate heptahydrate solution and continue stirring, add 0.13g sodium thiosulfate and 0.5mL tert-butyl hydrogen peroxide, heat to 95℃ and keep warm for 1.5h, filter, wash and dry to obtain microcapsules containing carboxyl groups; (3) Mix 4g of carboxyl-containing microcapsules, 120mL of deionized water, 2g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and 2g of N-hydroxysuccinimide, add 2.1g of amino acid ionic liquid containing double bonds and 30mL of N,N-dimethylformamide, keep warm at 25℃ for 5.5h, centrifuge, wash and dry to obtain composite microcapsules; The preparation of the amino acid ionic liquid containing double bonds includes the following steps: Under nitrogen protection, 0.5 mol of 1-vinylimidazolium, 0.5 mol of 3-bromopropylaminohydrobromide, and 100 mL of dimethyl sulfoxide were mixed, heated to 78 °C and stirred for 23 h. Ethyl acetate and anhydrous ethanol were added to precipitate the mixture, which was then washed, allowed to stand, and dried to obtain 1-vinyl-3-aminopropylimidazolium bromide. An equimolar amount of 1-vinyl-3-aminopropylimidazolium bromide and deionized water were mixed and passed through an anion exchange resin to obtain a hydroxylated ionic liquid. Then, 0.5 mol of L-phenylalanine and 80 mL of deionized water were mixed, and 0.5 mol of the hydroxylated ionic liquid was added. The mixture was stirred at 20 °C for 11.5 h and rotary evaporated to obtain an amino acid ionic liquid containing double bonds.

[0029] Example 3: A method for preparing a herbal moxibustion patch, comprising the following steps: S1: Grind and sieve the fruit wood vinegar powder, tourmaline, pearl powder, rhodiola rosea, dendrobium, honeysuckle, clove, alisma, and poria cocos, mix them evenly, and package them in graphene non-woven fabric. A self-adhesive sticker is placed on the graphene non-woven fabric to obtain a self-adhesive moisturizing pack. By weight, the self-adhesive moisturizing pack contains 10 parts fruit wood vinegar powder, 5 parts tourmaline, 3 parts pearl powder, 12 parts Rhodiola rosea, 4 parts Dendrobium, 3 parts honeysuckle, 10 parts clove, 3 parts Alisma plantago-aquatica, and 4 parts Poria cocos. S2: Mix cedar extract, iron powder, carbon powder, sodium chloride, vermiculite and water-absorbing resin, spray deionized water while mixing, seal and place for 12 hours, take it out and wrap it in sequence with breathable non-woven fabric, middle non-woven fabric and non-woven fabric cover cloth to obtain the heating layer. By mass, the heating layer contains 1 part cedar extract, 60 parts iron powder, 13 parts charcoal powder, 2 parts sodium chloride, 6 parts vermiculite, 4 parts water-absorbing resin, and 28 parts water. S3: Crush and sift saffron, chuanxiong, rhodiola rosea, dried mugwort leaves, dried ginger, angelica, cinnamon twig, clematis root, and evodia fruit, mix them evenly, and package them in skin-friendly non-woven fabric to obtain the herbal layer; By mass fraction, the herbaceous layer contained 3 parts saffron, 2.2 parts Ligusticum chuanxiong, 2.6 parts Rhodiola rosea, 8 parts dried Artemisia argyi, 10 parts dried ginger, 2 parts Angelica sinensis, 15 parts cinnamon twig, 2 parts Clematis armandii, and 1 part Evodia rutaecarpa. S4: From top to bottom, the printed non-woven fabric, heating layer, herbal layer and skin-friendly non-woven fabric are combined to obtain the main body of the heat patch. When using, the self-adhesive moisturizing pack is attached to the main body of the heat patch to obtain a herbal moxibustion heat patch. 2g of graphene nonwoven fabric was ultrasonically cleaned in anhydrous ethanol for 30 minutes, air-dried, and then transferred to a mixture of 90mL anhydrous ethanol, 10mL deionized water, and 4mL ammonia. 1.2mL vinyltriethoxysilane was added, and the mixture was stirred for 6 hours. After drying, the fabric was transferred to an antibacterial finishing solution for padding and then light-treated to obtain antibacterial graphene nonwoven fabric. 2g of skin-friendly nonwoven fabric was ultrasonically cleaned in anhydrous ethanol for 30 minutes, air-dried, and then transferred to a mixture of 90mL anhydrous ethanol, 10mL deionized water, and 4mL ammonia. 1.2mL vinyltriethoxysilane was added, and the mixture was stirred for 6 hours. After drying, the fabric was transferred to an antibacterial finishing solution for padding and then light-treated to obtain antibacterial skin-friendly nonwoven fabric. The working conditions for the dip-and-roll treatment are: two dips and two rolls, with a roll residue of 85%; the working conditions for the light treatment are: 365nm ultraviolet light irradiation for 2 minutes; the composition of the antibacterial finishing solution is: deionized water as solvent, containing 3g / L of composite microcapsules, 15g / L of carboxylated chitosan, 0.2g / L of penetrant, and 0.1g / L of initiator; The preparation of the composite microcapsules includes the following steps: (1) Tea tree oil and cedarwood oil were blended at a mass ratio of 7:3 to obtain a compound essential oil; (2) Mix 1g halloysite nanotubes, 90mL distilled water, 0.8g nonionic surfactant and 6g compound essential oil, stir in a 42℃ water bath for 30min, add 7g styrene, 7g ethyl acrylate and 4g ethylene glycol dimethacrylate and mix, then add 0.13g ammonium persulfate and 0.5mL ferric sulfate heptahydrate solution and continue stirring, add 0.13g sodium thiosulfate and 0.5mL tert-butyl hydrogen peroxide, heat to 97℃ and keep warm for 1h, filter, wash and dry to obtain microcapsules containing carboxyl groups; (3) Mix 4g of carboxyl-containing microcapsules, 120mL of deionized water, 2g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and 2g of N-hydroxysuccinimide, add 2.1g of amino acid ionic liquid containing double bonds and 30mL of N,N-dimethylformamide, keep warm at 30℃ for 5h, centrifuge, wash and dry to obtain composite microcapsules; The preparation of the amino acid ionic liquid containing double bonds includes the following steps: Under nitrogen protection, 0.5 mol of 1-vinylimidazolium, 0.5 mol of 3-bromopropylaminohydrobromide, and 100 mL of dimethyl sulfoxide were mixed, heated to 80 °C, and stirred for 22 h. Ethyl acetate and anhydrous ethanol were added to precipitate the mixture, which was then washed, allowed to stand, and dried to obtain 1-vinyl-3-aminopropylimidazolium bromide. An equimolar amount of 1-vinyl-3-aminopropylimidazolium bromide and deionized water were mixed and passed through an anion exchange resin to obtain a hydroxylated ionic liquid. Then, 0.5 mol of L-phenylalanine and 80 mL of deionized water were mixed, and 0.5 mol of the hydroxylated ionic liquid was added. The mixture was stirred at 25 °C for 11 h and then rotary evaporated to obtain an amino acid ionic liquid containing double bonds.

[0030] Comparative Example 1: Using Example 3 as the control group, the composite microcapsules were replaced with microcapsules containing carboxyl groups, while other processes were normal.

[0031] Comparative Example 2: Using Example 3 as the control group, the composite microcapsules were replaced with composite essential oils, while other processes were normal.

[0032] In the examples and comparative examples, the sieving was performed through a 120-mesh sieve.

[0033] Sources of raw materials used (for illustrative purposes only): Fruit vinegar powder (apple cider vinegar powder, food grade, 8%), tourmaline (98%), pearl powder (100%), cedarwood extract (cedarwood essential oil, 99%), tea tree essential oil (68647-73-4, 99%), vermiculite (98%), initiator (photoinitiator 2959, industrial grade), breathable nonwoven fabric (white, polypropylene, 75g / m²). 2 ), and the middle nonwoven fabric (graphene nonwoven fabric, 70g / m²). 2 ), non-woven fabric cover (white, polypropylene, 80g / m²) 2 Nonionic surfactant (Triton X100): commercially available; superabsorbent polymer (SAP-50), penetrant (JFC-U): Dahua; skin-friendly nonwoven fabric (XNS-A8): Suzhou Henglu Plastics Co., Ltd.; vinyltriethoxysilane (T103647), halloysite nanotubes (H431905), styrene (S110375), ethyl acrylate (E112943), ethylene glycol dimethacrylate (E106223), carboxylated chitosan (C10580) 0, 1-Vinylimidazolium V109377, 3-Bromopropylamine hydrobromide B106915, L-Phenylalanine P110425: Aladdin reagent; anhydrous ethanol, ammonia, ammonium persulfate, ferric sulfate heptahydrate, sodium thiosulfate, tert-butyl hydroperoxide, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, N,N-dimethylformamide, ethylene glycol, acetone, dimethyl sulfoxide, ethyl acetate, analytical grade, commercially available.

[0034] Performance testing: The antibacterial graphene nonwoven fabrics prepared in the examples and comparative examples were tested: Antibacterial properties: The antibacterial graphene nonwoven fabric was tested at 25°C using the plate method, with Escherichia coli and Staphylococcus aureus as the test bacteria. Water resistance: The antibacterial graphene nonwoven fabric is washed 20 times with standard water at 25℃, and after drying, its resistance to Staphylococcus aureus is tested. The antibacterial rate is compared with the initial antibacterial rate. If the difference in antibacterial rate is 0-1% including 1%, it is considered qualified; otherwise, it is unqualified. Temperature resistance: The antibacterial graphene nonwoven fabric was kept at 50℃ for 12 hours and then cooled to 25℃. The anti-Staphylococcus aureus resistance was tested again and compared with the initial antibacterial rate. If the difference in antibacterial rate was 0-1% including 1%, it was considered qualified; otherwise, it was unqualified. Table 1

[0035] This invention provides a herbal moxibustion warming patch and its preparation method. By optimizing the ingredients and process, this invention effectively improves the problems of traditional warming patches, such as limited functionality, hygiene risks, and poor applicability.

[0036] Comparing Example 3 with Comparative Examples 1 and 2, it can be seen that the composite microcapsules use a combination of tea tree oil (with broad-spectrum antibacterial properties) and cedarwood oil (with antibacterial and aromatic properties) as natural antibacterial agents. To achieve slow release and improve the stability of the natural antibacterial agent, carboxyl-containing microcapsules with polystyrene-ethyl acrylate as the shell material and composite essential oil as the core material were synthesized through emulsion polymerization. Halloysite nanotubes were inserted into the microcapsules as supporting fillers, thermal conductivity enhancers, and flame retardants, effectively enhancing the thermal stability and temperature control of the microcapsules. Further... To further improve the uniformity of carboxyl-containing microcapsules dispersed on the nonwoven fabric surface, a double-bonded amino acid ionic liquid was grafted onto the surface of the carboxyl-containing microcapsules using the reaction between carboxyl and amino groups. This double-bonded amino acid ionic liquid was prepared using L-phenylalanine as the anion and 1-vinyl-3-aminopropylimidazolium as the cation, thereby further improving the long-lasting antibacterial properties and biocompatibility of the microcapsules. Simultaneously, polymerizable double bonds were introduced into the microcapsule shell, allowing them to participate in the subsequent UV-cured crosslinking network and firmly crosslink onto the nonwoven fabric. This, in synergy with carboxylated chitosan, forms an antibacterial barrier, enhancing its antibacterial durability and improving the safety and lifespan of the heat pack.

[0037] The above description is merely an embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the present invention's specification under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A method for preparing a herbal moxibustion warming patch, characterized in that, Includes the following steps: S1: Grind and sieve the fruit wood vinegar powder, tourmaline, pearl powder, rhodiola rosea, dendrobium, honeysuckle, clove, alisma, and poria cocos, mix them evenly, and package them with graphene non-woven fabric. A self-adhesive sticker is provided on one side of the graphene non-woven fabric to obtain a self-adhesive moisturizing pack. S2: Mix cedar extract, iron powder, carbon powder, sodium chloride, vermiculite, and water-absorbing resin while spraying water. Seal and place. After taking it out, wrap it in a breathable non-woven fabric, a middle non-woven fabric, and a non-woven fabric cover to obtain the heating layer. S3: Crush and sift saffron, chuanxiong, rhodiola rosea, dried mugwort leaves, dried ginger, angelica, cinnamon twig, clematis root, and evodia fruit, mix them evenly, and package them in skin-friendly non-woven fabric to obtain the herbal layer; S4: The printed non-woven fabric, heating layer, herbal layer and skin-friendly non-woven fabric are laminated from top to bottom to obtain the main body of the heat patch. When using, the self-adhesive moisturizing pack is attached to the main body of the heat patch to obtain a herbal moxibustion heat patch.

2. The method for preparing a herbal moxibustion patch according to claim 1, characterized in that, By weight, the self-adhesive moisturizing packet contains 5-10 parts fruitwood vinegar powder, 3-5 parts tourmaline, 1-3 parts pearl powder, 7-12 parts Rhodiola rosea, 2-4 parts Dendrobium, 1-3 parts honeysuckle, 8-10 parts clove, 1-3 parts Alisma plantago-aquatica, and 2-4 parts Poria cocos.

3. The method for preparing a herbal moxibustion patch according to claim 1, characterized in that, By mass, the heating layer contains 0.5-1 parts of cedar extract, 50-60 parts of iron powder, 9-13 parts of charcoal powder, 1-2 parts of sodium chloride, 4-6 parts of vermiculite, 2-4 parts of water-absorbing resin, and 22-28 parts of water.

4. The method for preparing a herbal moxibustion patch according to claim 1, characterized in that, By mass fraction, the herbaceous layer contains 1-3 parts saffron, 1.8-2.2 parts Ligusticum chuanxiong, 1.6-2.6 parts Rhodiola rosea, 6-8 parts dried Artemisia argyi, 7-10 parts dried ginger, 1-2 parts Angelica sinensis, 11-15 parts cinnamon twig, 1-2 parts Clematis chinensis, and 0.5-1 part Evodia rutaecarpa.

5. The method for preparing a herbal moxibustion patch according to claim 1, characterized in that, The graphene nonwoven fabric or skin-friendly nonwoven fabric is ultrasonically cleaned in anhydrous ethanol, air-dried, transferred to a mixture of anhydrous ethanol, deionized water, and ammonia, vinyltriethoxysilane is added, stirred for 5-6 hours, removed and dried, and then transferred to an antibacterial finishing solution for padding and light treatment to obtain antibacterial graphene nonwoven fabric or antibacterial skin-friendly nonwoven fabric.

6. The method for preparing a herbal moxibustion patch according to claim 5, characterized in that, The working conditions for the dip-and-roll treatment are: two dips and two rolls, with a roll residue of 80-85%; the working conditions for the light treatment are: 365nm ultraviolet light irradiation for 1-2 minutes; the composition of the antibacterial finishing solution is: deionized water as solvent, containing 1-3g / L of composite microcapsules, 10-15g / L of carboxylated chitosan, 0.2g / L of penetrant, and 0.1g / L of initiator.

7. The method for preparing a herbal moxibustion patch according to claim 6, characterized in that, The preparation of the composite microcapsules includes the following steps: (1) Tea tree oil and cedarwood oil were blended at a mass ratio of 7:3 to obtain a compound essential oil; (2) Mix halloysite nanotubes, distilled water, nonionic surfactant and compound essential oil, stir in a water bath at 38-42℃ for 30-35 min, add styrene, ethyl acrylate and ethylene glycol dimethacrylate and mix, then add ammonium persulfate and ferric sulfate heptahydrate solution and continue stirring, add sodium thiosulfate and tert-butyl hydrogen peroxide, heat to 93-97℃ and keep warm for 1-2 h, filter, wash and dry to obtain microcapsules containing carboxyl groups; (3) Mix microcapsules containing carboxyl groups, deionized water, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, add amino acid ionic liquid containing double bonds and N,N-dimethylformamide, keep warm at 20-30℃ for 5-6 hours, centrifuge, wash and dry to obtain composite microcapsules.

8. The method for preparing a herbal moxibustion patch according to claim 7, characterized in that, The mass ratio of microcapsules containing carboxyl groups to amino acid ionic liquids containing double bonds is 4:2.

1.

9. The method for preparing a herbal moxibustion warming patch according to claim 7, characterized in that, The preparation of the amino acid ionic liquid containing double bonds includes the following steps: Under nitrogen protection, 1-vinylimidazolium, 3-bromopropylaminohydrobromide, and dimethyl sulfoxide were mixed, heated to 75-80℃ and stirred for 22-24 h. Ethyl acetate and anhydrous ethanol were added to precipitate the mixture, which was then washed, allowed to stand, and dried to obtain 1-vinyl-3-aminopropylimidazolium bromide. 1-vinyl-3-aminopropylimidazolium bromide and deionized water were mixed and passed through an anion exchange resin to obtain a hydroxylated ionic liquid. L-phenylalanine and deionized water were mixed, and the hydroxylated ionic liquid was added. The mixture was stirred at 18-25℃ for 11-12 h and then rotary evaporated to obtain an amino acid ionic liquid containing double bonds.

10. A herbal moxibustion warming patch, characterized in that, It is prepared by the preparation method described in any one of claims 1-8.

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