Plant-based sterilizing and acarus-killing shower gel for pets and preparation method thereof

Abstract

The invention provides plant-based sterilizing and acarus-killing shower gel for pets and a preparation method of the plant-based sterilizing and acarus-killing shower gel, and relates to the technical field of pet supplies. The plant-based sterilizing and acarus-killing shower gel for pets is prepared from the following components in percentage by mass: 3 to 8 weight percent of chinaberry seed extract, 1 to 3 weight percent of tea tree essential oil, 2 to 5 weight percent of thyme extract, 2 to 6 weight percent of wormwood extract, 8 to 15 weight percent of saponin plant extract, 2 to 4 weight percent of beta-cyclodextrin inclusion compound, 0.5 to 1.5 weight percent of sodium hyaluronate, 15 to 20 weight percent of amino acid surfactant, 5 to 10 weight percent of alkyl glycoside and the balance of water. The facial cleanser is prepared from, by weight, 3%-8% of cocamidopropyl betaine, 0.2%-0.8% of citric acid, 0.5%-2% of plant polysaccharide, 0.1%-0.5% of vitamin E, 2%-5% of glycerinum and the balance deionized water. Through synergistic compatibility of ternary plant active ingredients, application of a beta-cyclodextrin microencapsulation technology, selection of an amino acid surfactant and accurate control of the pH value, on the premise that no chemical preservative is added, perfect combination of efficient sterilization and mite removal, mildness, low irritation, lasting protection and excellent stability is achieved, and the effect of killing acarus is achieved. The method has important practical value and wide market prospect.

Description

Technical Field

[0001] This invention relates to the field of pet product technology, and in particular to a plant-based antibacterial and anti-mite pet shampoo and its preparation method. Background Technology

[0002] With improved living standards and changing pet ownership attitudes, pets have become important members of many families, leading to increased demand for their health care. Due to their physiology and habits, dogs are prone to skin infections caused by bacteria, fungi, and parasites. Skin diseases caused by canine scabies mites and Malassezia are common, making antibacterial and anti-mite pet shampoos an essential part of daily pet care.

[0003] Currently, pet shampoos on the market have the following problems: First, traditional products mostly use chemically synthesized surfactants, which have strong cleaning power but are highly irritating to pets' skin. Long-term use may lead to dry skin, itching, or even allergies. Second, existing products often use single chemical ingredients for sterilization and mite removal, which have immediate effects but short-lasting protection, requiring frequent bathing and increasing the burden on the skin. Third, volatile components in natural plant extracts, such as essential oils, are easily volatilized and oxidized, resulting in short product shelf life, low retention of active ingredients, and poor stability.

[0004] Furthermore, canine skin has a pH that tends towards neutral or slightly alkaline. Many pet shampoos deviate from this range; excessive acidity can cause skin irritation and decrease the stability of amino acid surfactants, while excessive alkalinity can damage the skin barrier function and increase transepidermal water loss. Additionally, existing products often contain a lot of ingredients without proper scientific formulation design, making it difficult for the ingredients to synergistically enhance each other, and sometimes even leading to antagonistic effects, resulting in poor overall performance.

[0005] Patent CN 109481379 A discloses a pet shampoo and its preparation method, using components such as bentonite clay and finely powdered oats, which can react with odor-causing ingredients to achieve effects such as cleaning, relieving itching, and long-lasting fragrance. However, it lacks targeted antibacterial and anti-mite activity, has limited inhibitory effect on common pathogenic microorganisms, and is difficult to meet the needs of pet skin disease prevention and treatment. Furthermore, it does not consider the stability and sustained-release issues of active ingredients, resulting in short-lasting protection and requiring frequent bathing to maintain the effect. Patent CN108403536 A also discloses a pet shampoo and its preparation method, incorporating plant extracts into the formula. However, it lacks sufficient protection for the stability of volatile plant essential oils and other active ingredients, affecting the product's shelf life and efficacy stability. Moreover, its antibacterial and anti-mite effects are not sustained, and the active ingredients struggle to form a long-lasting protective layer on the skin surface.

[0006] To address the aforementioned issues, it is necessary to develop a pet shampoo product that integrates the advantages of highly effective sterilization and mite removal, gentle and low-irritation properties, long-lasting protection, and good stability to overcome the problems existing in the current technology. Summary of the Invention

[0007] The first aspect of this invention is to provide a plant-based antibacterial and anti-mite pet shampoo, comprising the following components by weight percentage: The composition includes: 3-8 wt.% neem seed extract, 1-3 wt.% tea tree oil, 2-5 wt.% thyme extract, 2-6 wt.% artemisia extract, 8-15 wt.% saponin plant extracts, 2-4 wt.% β-cyclodextrin inclusion complex, 0.5-1.5 wt.% sodium hyaluronate, 15-20 wt.% amino acid surfactant, 5-10 wt.% alkyl glycoside (APG), 3-8 wt.% cocamidopropyl betaine, 0.2-0.8 wt.% citric acid, 0.5-2 wt.% plant polysaccharides, 0.1-0.5 wt.% vitamin E, 2-5 wt.% glycerol, and the balance being deionized water.

[0008] Preferably, the amino acid surfactant is sodium lauroyl glutamate and / or sodium cocoyl glutamate.

[0009] Preferably, the plant polysaccharide is xanthan gum and / or guar gum.

[0010] Preferably, the saponin plant extract is Sapindus mukorossi and / or tea saponin.

[0011] Preferably, the pH of the plant-based antibacterial and anti-mite shampoo for pets is 6.2-7.2.

[0012] Preferably, the relative density of the neem seed extract is 1.05-1.15. The neem seed extract of the present invention can be a commercially available product or prepared using conventional methods. For example, the neem seed extract can be obtained by ultrasonic-assisted ethanol extraction followed by concentration, wherein the extraction temperature is 40-50℃, the ultrasonic power is 200-400 W, and the extraction time is 1-2 h.

[0013] Preferably, the relative density of the thyme extract and artemisia extract is 1.10-1.20. The thyme extract and artemisia extract of the present invention can be commercially available products or prepared using conventional methods. For example, the thyme extract and artemisia extract can be obtained by water extraction and alcohol precipitation followed by concentration. The specific steps are as follows: the raw materials are decocted at 80-95℃ 2-3 times, 1-1.5 h each time; the extracts are combined; ethanol is added to a concentration of 60-70%; the mixture is allowed to stand for 12-24 h; the supernatant is collected and concentrated to obtain the final product.

[0014] A second aspect of the present invention is to provide a method for preparing the aforementioned plant-based antibacterial and anti-mite shampoo for pets, comprising the following steps: S1. Weigh the raw materials according to the proportion, mix tea tree oil with β-cyclodextrin, stir and react, freeze dry to obtain tea tree oil β-cyclodextrin inclusion complex; S2. Add the neem seed extract, artemisia extract, and thyme extract to 30-40% of the total amount of deionized water according to the proportion. Then add the tea tree essential oil β-cyclodextrin inclusion complex and emulsify under high shear to fully disperse and dissolve the inclusion complex. Add sodium hyaluronate and vitamin E in sequence and stir evenly to obtain the premixed solution of the active ingredients A. S3. Heat the remaining deionized water, and slowly add amino acid surfactant, alkyl glycoside, and cocamidopropyl betaine in sequence. Stir until completely dissolved before adding the next ingredient. Add saponin plant extract and stir to obtain cleaning matrix solution B. S4. Cool the cleaning matrix solution B, and slowly add the premixed solution of the active ingredient A while stirring continuously. Use a high-shear emulsifier to emulsify and ensure that the system is uniform and stable to obtain mixture C. S5. Disperse the plant polysaccharides in glycerol to form a paste. Add the plant polysaccharide paste to mixture C while stirring continuously. Stir until the target viscosity is reached. Adjust the pH value to 6.2-7.2 with citric acid solution and stir to stabilize the pH value to obtain a plant-based antibacterial and anti-mite shampoo for pets.

[0015] Preferably, in step S1, the stirring reaction temperature is 45-55℃, the stirring reaction time is 2-4 h, and the inclusion rate of the tea tree oil β-cyclodextrin inclusion complex is ≥85%.

[0016] Preferably, in step S2, the high-shear emulsification speed is 3000-5000 rpm, the temperature is 35-45℃, and the emulsification time is 20-30 min.

[0017] Preferably, in step S3, the temperature of the deionized water is 60-70°C.

[0018] Preferably, in step S4, the clean matrix solution B is cooled to 40-50℃; the continuous stirring speed is 800-1200 rpm; the addition time of the premixed solution A is controlled at 15-20 min; the emulsification speed is 4000-6000 rpm, and the emulsification time is 25-35 min.

[0019] Preferably, in step S5, the target viscosity is 3000-8000 mPa·s at 25°C.

[0020] Compared with the prior art, the beneficial technical effects of the present invention are as follows: This invention employs a ternary compound system of neem seed extract, tea tree oil, and thyme extract, combined with microencapsulation technology of tea tree oil β-cyclodextrin inclusion complex. This not only solves the problem of easy loss of volatile active ingredients, achieving sustained release of active ingredients and dual penetration promotion, but also enhances skin penetration depth and antibacterial protection, resulting in broad-spectrum, highly effective, and long-lasting bactericidal and mite-killing effects. Furthermore, it constructs a gentle cleansing system using amino acid surfactants in combination with alkyl glycosides and cocamidopropyl betaine, along with moisturizing and care ingredients such as sodium hyaluronate, vitamin E, plant polysaccharides, and glycerin, as well as the anti-inflammatory and antipruritic effects of plant extracts. This achieves an organic combination of cleansing and care, providing excellent moisturizing and antipruritic effects to relieve skin itching and improve pet comfort. At the same time, the product's pH value is precisely controlled within the range of 6.2-7.2 to ensure the product's gentleness and stable efficacy. The product produces rich and stable foam, is easy to rinse without residue, provides a good user experience, and exhibits excellent stability, ensuring stable efficacy throughout its shelf life. Attached Figure Description

[0021] The present invention will be further described below with reference to the accompanying drawings.

[0022] Figure 1 This is a flowchart illustrating the preparation process of the plant-based antibacterial and anti-mite pet shampoo of the present invention. Detailed Implementation

[0023] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention.

[0024] The relative density of the neem seed extract involved in the following examples or comparative examples is 1.10, prepared by ultrasound-assisted ethanol extraction; the relative density of the thyme extract is 1.15, prepared by water extraction and alcohol precipitation; the relative density of the artemisia extract is 1.15, prepared by water extraction and alcohol precipitation.

[0025] Unless otherwise specified, all experiments were repeated three times, and the results are expressed as averages.

[0026] The raw material composition of Examples 1-5 is shown in Table 1.

[0027] Table 1. Raw material composition of Examples 1-5

[0028] The preparation methods of the products in Examples 1-5 are as follows: S1. Weigh the raw materials according to the proportion, dissolve β-cyclodextrin in deionized water, stir until completely dissolved, slowly add tea tree oil, heat to 50℃, stir continuously for 3 h, cool to room temperature, stand overnight at 4℃, freeze dry for 24 h (-50℃, vacuum degree <10 Pa) to obtain tea tree oil β-cyclodextrin inclusion complex with inclusion rate ≥85%; S2. Prepare ingredient container A, weigh 35% deionized water, add it to the ingredient container, add neem seed extract, artemisia extract, thyme extract in sequence, add tea tree essential oil β-cyclodextrin microcapsules, shear emulsify at 4000 rpm and 40℃ for 25 min, then add sodium hyaluronate and vitamin E in sequence under stirring, continue stirring for 10 min, cool to 35℃, and set aside. S3. Prepare ingredient tank B. Heat the remaining deionized water to 65°C. Slowly add sodium lauroyl glutamate while continuously stirring until completely dissolved and the solution is clear and transparent. Add APG and stir evenly. Add cocamidopropyl betaine and stir evenly. Add saponin plant extracts and stir until completely dissolved. S4. Cool the cleaning matrix solution B to 45℃, prepare the main mixing tank, transfer the cleaning matrix solution B to the main mixing tank, slowly add the premixed solution A under stirring, after the addition is complete, shear emulsify at 5000 rpm and 41℃±1℃ for 30 min, cool to 35℃ to obtain mixture C. Step S5: Slowly sprinkle xanthan gum into glycerin while stirring with a glass rod to form a uniform paste. Add the plant polysaccharide paste at 35°C and 600 rpm, stir well, then add citric acid and stir well again. Cool down to 30°C and let stand for 2 hours to remove bubbles.

[0029] Test Example 1: Sterilization and Mite Removal Performance Examples 1-5: Testing of the antibacterial and anti-mite properties of shower gels.

[0030] The method for detecting the kill rate of Escherichia coli (ATCC 25922) is as follows: Take 1 mL of bacterial suspension (5 × 10 5 Add CFU / mL to 9 mL of sample diluent and incubate at 25±1℃ for 8 min (simulating actual bathing time). Take 1 mL of the incubated mixture and add 9 mL of diluent containing a neutralizing agent (0.5% Tween 80 + 0.07% lecithin) to neutralize residual antibacterial components. Perform serial dilutions. Take the appropriate dilution and inoculate it onto nutrient agar plates using the pour method. Incubate at 37℃ for 48 h and count the colonies. Use sterile physiological saline instead of sample diluent as a blank control and perform the same procedure.

[0031] Kill rate (%) = [(number of colonies in control group - number of colonies in experimental group) / number of colonies in control group] × 100%.

[0032] The method for testing the kill rate of Staphylococcus aureus (ATCC 6538) is the same as that for Escherichia coli.

[0033] The inhibition rate test method for Malassezia pachydermatis (ATCC 14522) is as follows: Malassezia was inoculated onto modified Dixon agar medium (containing 1% Tween 80, 3.6% maltose, 2% ox bile, 1% peptone, 0.2% oleic acid, and 0.05% glycerol) and incubated at 32°C for 72 h. The culture was then prepared with sterile PBS buffer to a concentration of 1-5 × 10⁻⁵. 4 Prepare a bacterial suspension at CFU / mL; dilute 1 g of sample to 10 mL with PBS, mix the bacterial suspension and sample dilution at a ratio of 1:9, and incubate at 32°C for 10 min; after incubation, serially dilute the mixture and plate it onto modified Dixon agar plates, incubate at 32°C for 72-96 h, count the colonies, and calculate the inhibition rate. Use sterile physiological saline instead of sample dilution as a blank control, and perform the same procedure.

[0034] Inhibition rate (%) = [(number of colonies in control group - number of colonies in experimental group) / number of colonies in control group] × 100%.

[0035] The test method for canine scabies mite repellency rate is as follows: The canine scabies mite (Sarcoptes scabiei var. canis) was collected clinically. A 9 cm diameter petri dish was used, divided into two equal halves with filter paper. One half of the filter paper was treated with the sample dilution solution (1% concentration) and air-dried, while the other half was treated with distilled water as a control. Fifty live mites were placed at the central dividing line of the petri dish and incubated at 25±1℃ and 75±5% relative humidity.

[0036] Repellency rate (%) = [(Number of mites in control area - Number of mites in treatment area) / (Number of mites in control area + Number of mites in treatment area)] × 100%.

[0037] The test results are shown in Table 2.

[0038] Table 2 Results of bactericidal and mite-killing performance tests

[0039] Test Example 2: Skin Safety and Irritation Test The skin irritation test was carried out in accordance with GB / T 16886.10-2017 "Biological evaluation of medical devices - Part 10: Tests for irritation and skin sensitization". The irritation grading criteria are as follows: Grade 0 (PII = 0, no irritation), Grade I (0 < PII ≤ 0.5, slight irritation), Grade II (0.5 < PII ≤ 2.0, mild irritation), and Grade III (2.0 < PII ≤ 5.0, moderate irritation). The skin sensitivity test was carried out in accordance with the guinea pig maximization test method (GPMT) of GB / T 16886.10-2017, and the test period was 21 days. The skin moisture retention test was carried out using a skin moisture tester. The trans-epidermal water loss (TEWL) test was carried out using a Tewameter® TM 300 (Courage + Khazaka, Germany) instrument. The evaluation test method for the antipruritic effect was the canine behavior observation method, and the reduction rate of scratching frequency (%) = [(number of scratching times in the control group - number of scratching times in the test group) / number of scratching times in the control group] × 100%.

[0040] The results showed that the PII values of the body washes in Examples 1-5 were all 0, and they were determined to be Grade 0 (no irritation); the positive rate of the sensitivity test was 0%, and there was no sensitization.

[0041] Test Example 3 Detection of moisturizing and antipruritic performance The detection results of the bactericidal and acaricidal performance of the body washes in Examples 1-5 are shown in Table 3.

[0042] Table 3 Detection results of moisturizing and antipruritic performance

[0043] Test Example 4 Test of cleaning performance and user experience The test results of the cleaning performance and user experience of the body washes in Examples 1-5 are shown in Table 4.

[0044] Table 4 Detection results of cleaning performance and user experience

[0045] Test Example 5 Stability detection The stability detection results of the body washes in Examples 1-5 are shown in Table 5.

[0046] Table 5 Stability detection results

[0047] Comparative Example 1 The difference from Example 1 is that the Melia azedarach seed extract was removed and replaced with an equal amount of deionized water, and the other component ratios remained unchanged.

[0048] The E. coli kill rate of this comparative product decreased by 14.63% compared to Example 1 (from 99.8% to 85.2%), the Staphylococcus aureus kill rate decreased by 11.76% compared to Example 1 (from 99.5% to 87.8%), the Malassezia inhibition rate decreased by 14.15% compared to Example 1 (from 98.2% to 84.3%), the canine scabies mite repellency rate decreased by 18.65% compared to Example 1 (from 96.5% to 78.5%), the antibacterial protection period decreased by 41.54% compared to Example 1 (from 6.5 days to 3.8 days), the mite-repelling protection period decreased by 52.94% compared to Example 1 (from 6.8 days to 3.2 days), and the anti-inflammatory effect decreased by 62% compared to Example 1 (the erythema recovery time was significantly prolonged). It is evident that the bactericidal and mite-killing effects significantly decreased after removing the neem seed extract, especially the repellency rate against canine scabies mites.

[0049] Comparative Example 2 The difference from Example 1 is that the β-cyclodextrin inclusion complex of tea tree oil was removed and replaced with an equal amount of deionized water, while the proportions of other components remained unchanged.

[0050] The E. coli kill rate of this comparative product decreased by 8.32% compared to Example 1 (from 99.8% to 91.5%), the Staphylococcus aureus kill rate decreased by 17.29% compared to Example 1 (from 99.5% to 82.3%), the Malassezia inhibition rate decreased by 18.94% compared to Example 1 (from 98.2% to 79.6%), the duration of antibacterial protection decreased by 61.54% compared to Example 1 (from 6.5 days to 2.5 days), the duration of mite protection decreased by 58.82% compared to Example 1 (from 6.8 days to 2.8 days), and the 12-month retention rate of active ingredients decreased by 14.93% compared to Example 1 (from 92.3% to 78.5%). This demonstrates that removing the β-cyclodextrin inclusion complex of tea tree oil significantly reduces the inhibitory ability against fungi and Gram-positive bacteria.

[0051] Comparative Example 3 The difference from Example 1 is that the thyme extract is removed and replaced with an equal amount of deionized water, while the proportions of other components remain unchanged.

[0052] The E. coli kill rate of this comparative product decreased by 6.31% compared to Example 1 (from 99.8% to 93.5%), the Staphylococcus aureus kill rate decreased by 8.34% compared to Example 1 (from 99.5% to 91.2%), the antipruritic effect decreased by 29.33% compared to Example 1 (from 82.5% to 58.3%), and the synergistic effect coefficient decreased by 20% compared to Example 1 (from 1.35 to 1.08). This demonstrates that removing the thyme extract significantly weakens the anti-inflammatory and antipruritic effects.

[0053] Comparative Example 4 The difference from Example 1 is that the tea tree oil β-cyclodextrin inclusion complex is replaced with tea tree oil (keeping the content of active ingredients in tea tree oil consistent), the rest is made up with deionized water, and the proportions of other components remain unchanged.

[0054] The immediate E. coli eradication rate of this comparative product decreased by 1.30% compared to Example 1 (from 99.8% to 98.5%), the duration of antibacterial protection decreased by 72.31% compared to Example 1 (from 6.5 days to 1.8 days), the duration of mite-killing protection decreased by 70.59% compared to Example 1 (from 6.8 days to 2.0 days), the 12-month retention rate of active ingredients decreased by 29.36% compared to Example 1 (from 92.3% to 65.2%), and the fragrance retention time decreased by 83.33% compared to Example 1 (from 48 hours to 8 hours). This demonstrates that microencapsulation technology achieves sustained release and stable protection of active ingredients.

[0055] Comparative Example 5 The difference from Example 1 is that sodium lauroyl glutamate is replaced with an equal amount of sodium dodecyl sulfate (SLS), while the proportions of other components remain unchanged.

[0056] The detergency of this comparative product increased by 1.76% compared to Example 1 (from 96.8% to 98.5%), the foam richness increased by 15.38% compared to Example 1 (from 195 mm to 225 mm), the skin irritation increased from level 0 to level 2 (moderate irritation), the TEWL increase rate increased by 10.16 times compared to Example 1 (soaring from +3.2% to +32.5%), and the positive rate of the sensitivity test increased by 18.0% compared to Example 1 (from 0% to 18.0%). This demonstrates that while chemical surfactants have strong cleaning power, their skin safety is severely compromised.

[0057] Comparative Example 6 The difference from Example 1 is that citric acid was used to adjust the pH to 5.0, while the proportions of other components remained unchanged.

[0058] Compared to Example 1, the pH value of this comparative product was 5.00, resulting in a 3.31% decrease in the E. coli kill rate (from 99.8% to 96.5%), an increase in skin irritation from grade 0 to grade 1 (mild irritation), and an 8.0% increase in the positive rate of the sensitivity test (from 0% to 8.0%). This demonstrates that an excessively acidic pH of 5.0 leads to a decrease in the stability of amino acid surfactants.

[0059] Comparative Example 7 The difference from Example 1 is that the amount of citric acid is reduced, the pH value is adjusted to 8.0, and the proportions of other components remain unchanged.

[0060] The detergency of this comparative product increased by 1.45% compared to Example 1 (from 96.8% to 98.2%), skin irritation increased from level 0 to level 1-2 (mild to moderate irritation), TEWL increase rate increased by 7.91 times compared to Example 1 (from +3.2% to +28.5%), and sensitivity test positive rate increased by 14.0% compared to Example 1 (from 0% to 14.0%). This demonstrates that an alkaline environment at pH 8.0 disrupts the skin barrier function.

[0061] Comparative Example 8 The difference from Example 1 is that: the tea tree oil β-cyclodextrin inclusion complex and thyme extract were removed, the neem seed extract was increased to 8 wt.% (limited upper limit), the balance was made up with deionized water, and the proportions of other components remained unchanged.

[0062] The E. coli kill rate of this comparative product decreased by 11.32% compared to Example 1 (from 99.8% to 88.5%), the Staphylococcus aureus kill rate decreased by 21.41% compared to Example 1 (from 99.5% to 78.2%), the Malassezia inhibition rate decreased by 26.37% compared to Example 1 (from 98.2% to 72.3%), and the synergistic effect coefficient decreased by 31.85% compared to Example 1 (from 1.35 to 0.92). This demonstrates that a single component cannot achieve the synergistic effect of a ternary compound.

[0063] Comparative Example 9 The difference from Example 1 is that the β-cyclodextrin inclusion complex of tea tree oil was removed, leaving only β-cyclodextrin. The missing part was replaced with an equal amount of deionized water, while the proportions of other components remained unchanged.

[0064] The immediate E. coli eradication rate of this comparative product decreased by 1.30% compared to Example 1 (from 99.8% to 98.5%), the duration of antibacterial protection decreased by 41.54% compared to Example 1 (from 6.5 days to 3.8 days), the skin penetration depth of the active ingredient decreased by 41.05% compared to Example 1 (from 285 μm to 168 μm), and the residue of the active ingredient after 72 h decreased by 81.0% compared to Example 1 (from 42% to 8%). This demonstrates that the β-cyclodextrin inclusion complex has a dual penetration-enhancing effect.

[0065] In summary, the ternary compound system exhibits a synergistic effect; all three components are indispensable, working together to achieve broad-spectrum, highly effective, and long-lasting bactericidal and mite-killing effects. β-cyclodextrin microencapsulation technology enables sustained release, stabilization, and solubilization and dispersion of the active ingredients, extending the protection period. Amino acid surfactants significantly reduce skin irritation while maintaining cleansing power. Precise pH control ensures both product stability and bactericidal efficacy, while also guaranteeing skin safety. The penetration-enhancing effect of β-cyclodextrin inclusion complexes improves the skin penetration depth of the active ingredients and extends the duration of protection. This invention achieves 12 months of stability without the addition of chemical preservatives.

[0066] This invention achieves an optimal balance between antibacterial and anti-mite effects, skin safety, and product stability through a plant-based formulation system, providing a new technical solution for the development of pet care products.

Claims

1. A plant-based sterilizing and acaricidal body wash for pets, characterized by, The following components are included in the percentage of mass: Melia azedarach seed extract 3-8 wt.%, tea tree oil 1-3 wt.%, thyme extract 2-5 wt.%, wormwood extract 2-6 wt.%, saponin plant extract 8-15 wt.%, β-cyclodextrin inclusion compound 2-4 wt.%, sodium hyaluronate 0.5-1.5 wt.%, amino acid surfactant 15-20 wt.%, alkyl glycoside 5-10 wt.%, cocamidopropyl betaine 3-8 wt.%, citric acid 0.2-0.8 wt.%, plant polysaccharide 0.5-2 wt.%, vitamin E 0.1-0.5 wt.%, glycerol 2-5 wt.%, and the balance is deionized water; The pH of the plant-based sterilization and acarid-removing shower gel for pets is 6.2-7.

2.

2. The plant-based sterilization and acaricidal body wash for pets according to claim 1, characterized in that, The amino acid surfactant is sodium lauroyl glutamate and / or sodium cocoyl glutamate.

3. The plant-based sterilization and acaricidal body wash for pets according to claim 1, characterized in that, The plant polysaccharide is xanthan gum and / or guar gum.

4. The plant-based sterilization and acaricidal body wash for pets according to claim 1, characterized by, The saponin plant extract is soapberry and / or tea saponin.

5. The plant-based sterilizing and acaricidal body wash for pets according to claim 1, characterized in that, The relative density of the Melia azedarach seed extract is 1.05-1.

15.

6. The plant-based sterilizing and acaricidal body wash for pets according to claim 1, characterized in that, The relative density of the thyme extract is 1.10-1.

20.

7. The plant-based sterilizing and acaricidal body wash for pets according to claim 1, characterized in that, The relative density of the wormwood extract is 1.10-1.

20.

8. A method of preparing the pet use plant based germ killing and mite removing body wash of any one of claims 1-7, characterized in that, The steps include: S1, weighing the raw materials, mixing tea tree oil with β-cyclodextrin, stirring and reacting, freeze-drying to obtain tea tree oil β-cyclodextrin inclusion compound; S2, adding Melia azedarach seed extract, wormwood extract, and thyme extract to 30-40% of the total amount of deionized water in the formula, then adding tea tree oil β-cyclodextrin inclusion compound, high shear emulsification, and fully dispersing and dissolving the inclusion compound, and then adding sodium hyaluronate and vitamin E in sequence, stirring uniformly to obtain a functional ingredient premix A; S3, heating the balance of deionized water, slowly adding amino acid surfactant, alkyl glycoside, and cocamidopropyl betaine in sequence, stirring to completely dissolve each one before adding the next raw material, adding saponin plant extract, and stirring to obtain a cleaning base liquid B; S4, cooling the cleaning base liquid B, slowly adding the functional ingredient premix A under continuous stirring, emulsifying with a high shear emulsifier to ensure uniformity and stability of the system, and obtaining a mixture C; S5, dispersing plant polysaccharide in glycerol to make a paste, adding the plant polysaccharide paste to the mixture C under continuous stirring, stirring to the target viscosity, adjusting the pH value to 6.2-7.2 with a citric acid solution, and stirring to stabilize the pH value to obtain a plant-based sterilization and acarid-removing shower gel for pets.

9. The production method according to claim 8, characterized by, In step S1, the stirring and reaction temperature is 45-55℃, and the stirring and reaction time is 2-4 h; the inclusion rate of the tea tree oil β-cyclodextrin inclusion compound is ≥85%.

10. The preparation method according to claim 8, characterized in that, In step S5, the target viscosity at 25℃ is 3000-8000 mPa·s.

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