Moisturizing repair type hand sanitizer

Abstract

The application discloses a moisturizing and repairing type hand sanitizer and relates to the technical field of daily chemical products. The moisturizing and repairing type hand sanitizer comprises the following components in percentage by mass: 11-15% of a surfactant, 0.6-1.0% of an antibacterial composition, 4.1-5.7% of a moisturizing and skin-moistening composition and 0.25-0.5% of an auxiliary agent. The surfactant comprises multiple kinds of cocoglucoside, decyl glucoside and potassium cocoyl glutamate. The antibacterial composition comprises multiple kinds of tea tree essential oil, polylysine hydrochloride and chitosan. The moisturizing and skin-moistening composition comprises multiple kinds of panthenol, shea butter, sodium hyaluronate and honeysuckle extract. The auxiliary agent comprises xanthan gum and / or citric acid. The moisturizing and repairing type hand sanitizer provided by the application realizes multiple advantages such as naturalness, mildness, skin care and health through the compounding design of multiple systems such as surfactants, antibacterial agents, moisturizing agents and skin-moistening agents.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily chemical products, and particularly relates to a moisturizing and repairing type hand sanitizer. BACKGROUND

[0002] In daily life, hand sanitizer is a hand cleaning product frequently used by people. At present, the common hand sanitizer on the market is mainly composed of chemical synthetic substances, and the proportion of natural mild ingredients is very small, and natural active ingredients and skin care substances are rarely added. Among them, the chemical synthetic surfactant is used to achieve the cleaning function, the preservative is used to prolong the shelf life of the product, and some organic solvents and other substances are commonly used in hand sanitizer. When developing and producing, the manufacturer often only focuses on the cleaning effect, but ignores the repair after excessive cleaning. When people frequently use hands to contact such hand sanitizer containing a large amount of chemical synthetic ingredients and lacking sufficient repair ingredients, the skin, especially the hand skin, is easily irritated, and symptoms such as itching and redness occur.

[0003] More attention should be paid to the fact that in order to achieve better cleaning effect, many hand sanitizers add high content of surfactant. However, in the cleaning process, the high content of surfactant often leads to excessive cleaning of the hands. The surface of the hand skin originally has a layer of oil that plays a protective role. The high content of surfactant will excessively remove this layer of oil, so that the hand skin loses the nourishment and protection of the oil, and becomes dry, and even produces obvious irritation. Long-term use may damage the barrier function of the hand skin, and due to the lack of effective repair ingredients, such damage is difficult to improve in time.

[0004] From the perspective of people's needs, with the development of society and the continuous improvement of people's health and environmental protection awareness, people's requirements for hand sanitizer have gone beyond simple cleaning, and have covered many aspects such as hygiene, antibacterial, health, beauty, and environmental protection. For example, people hope that the hand sanitizer can effectively resist bacteria and protect hygiene; hope that the ingredients are mild and do not harm health, and can repair the hands after cleaning; hope that in the process of use and production, it can be more green and environmentally friendly, and even use renewable raw materials. However, the existing hand sanitizer has obvious shortcomings in these aspects, and has been difficult to meet people's increasingly diversified needs, so the future of the hand sanitizer industry will develop towards green, environmentally friendly, renewable and repairable. SUMMARY

[0005] The technical problem to be solved by the present application is:

[0006] 1. Surface activity safety deficiency: Most products use chemically synthesized surface activity (such as sulfate), which can easily damage the skin barrier during cleaning, leading to redness and tightness in sensitive skin, pregnant and infant populations; and traditional surface activity has low biodegradability (<60%), which can easily pollute water bodies;

[0007] 2. Single and irritating antibacterial effect: Traditional antibacterial ingredients are mostly chemical preservatives (such as phenoxyethanol), which can only inhibit surface bacteria in the short term and cannot resist stubborn bacteria (such as Staphylococcus aureus) in the long term, and some ingredients are irritating to damaged skin;

[0008] 3. Poor moisturizing and skin synergism: Most products only add a single moisturizing ingredient (such as glycerol), which is difficult to meet the "moisturizing-locking-repairing" needs at the same time, especially after makeup removal or barrier damage, skin dryness cannot be effectively alleviated;

[0009] 4. Imbalance between formula stability and use: Some natural formulas have poor compatibility of ingredients, which can easily cause stratification and uneven viscosity; and the pH value does not match the weak acidic environment of the skin (pH 5.5-6.0), which further aggravates skin irritation.

[0010] Based on the above technical problems, the present application provides a moisturizing and repairing type hand sanitizer, which is designed by the synergistic design of "surface activity (surfactant)-antibacterial (antibacterial composition)-moisturizing and skin (moisturizing and skin composition)-adjuvant" four systems to solve the above problems.

[0011] Specifically includes the following technical solutions:

[0012] A moisturizing and repairing type hand sanitizer is provided, which comprises the following mass percentage components:

[0013] Surfactant 11-15%, antibacterial composition 0.6-1.0%, moisturizing and skin composition 4.1-5.7%, and adjuvant 0.25-0.5%;

[0014] The surfactant includes a plurality of cocoglycoside, decyl glucoside, and potassium cocoyl glutamate;

[0015] The antibacterial composition includes a plurality of tea tree oil, polylysine hydrochloride, and chitosan;

[0016] The moisturizing and skin composition includes a plurality of panthenol, shea butter, sodium hyaluronate, and honeysuckle extract;

[0017] The adjuvant includes xanthan gum and / or citric acid.

[0018] Further, the surfactant is composed of cocoglycoside, decyl glucoside, and potassium cocoyl glutamate.

[0019] Preferably, the coconut-based glucoside is extracted by enzymatic hydrolysis, and the potassium cocoyl glutamate is prepared by fermentation.

[0020] Among them, coconut-based glucoside (APG-12): non-ionic surfactant, derived from coconut oil and glucose, mild cleaning and enhanced formulation compatibility); decyl glucoside (APG-10): non-ionic surfactant, short-chain structure improves cleaning power, and APG-12 synergistically reduces irritation; potassium cocoyl glutamate: amino acid surfactant, derived from coconut oil and glutamic acid, containing skin-friendly amino acid groups, repairing barrier damage during cleaning.

[0021] Further, the mass percentage of the coconut-based glucoside in the moisturizing and repairing hand sanitizer is 6-8%, the mass percentage of the decyl glucoside in the moisturizing and repairing hand sanitizer is 2-3%, and the mass percentage of the potassium cocoyl glutamate in the moisturizing and repairing hand sanitizer is 3-4%.

[0022] Further, the mass ratio of the coconut-based glucoside, decyl glucoside and potassium cocoyl glutamate is (6.5-7):(2.5-3):(3-4).

[0023] Among them, the 100% natural surfactant complex system formed by the surfactant of the present application has the following advantages:

[0024] 1. "Non-ionic glucoside + amino acid surfactant" is used to improve the cleaning power while reducing the damage rate of surfactant to skin lipids (actual damage rate <5%, much lower than the 30% of traditional sulfate surfactant);

[0025] 2. The whole process uses natural raw material extraction process (such as enzymatic extraction of glucoside and fermentation method to prepare amino acid surfactant), without chemical synthetic intermediates, ensuring 100% natural origin;

[0026] 3. The biodegradability is detected by GB / T15818-2018 standard, and the result is ≥98%, which avoids water pollution.

[0027] Further, the antibacterial composition is composed of tea tree oil, polylysine hydrochloride and chitosan.

[0028] Among them, tea tree oil (plant source): contains terpinen-4-ol active ingredient, quickly inhibits surface pathogenic bacteria; polylysine hydrochloride (microbial source): microbial fermentation product, cationic polypeptide structure, penetrates stubborn bacterial cell membrane; chitosan (mineral source): derived from shrimp and crab shell extract, contains amino polysaccharide structure, forms antibacterial membrane.

[0029] Preferably, the preparation method of the antibacterial composition comprises the following steps: stirring and mixing tea tree oil, polylysine hydrochloride and chitosan at 35-40 DEG C to obtain the antibacterial composition.

[0030] The antibacterial composition of the present application forms a triple antibacterial complex system, which has the following advantages:

[0031] 1. The triple antibacterial mechanism of "instant, long-acting and protection" is constructed: the antibacterial rate of tea tree oil is greater than or equal to 99% within 10 minutes (instant), the antibacterial time of polylysine hydrochloride is prolonged to 72 hours (long-acting), and chitosan forms a transparent antibacterial film (about 5-10 microns thick) on the skin surface to reduce the secondary adhesion of bacteria.

[0032] 2. The low-temperature compounding process (35-40 DEG C) is used to avoid the volatilization of tea tree oil at high temperature, and the content of active ingredients is greater than or equal to 95%.

[0033] 3. The skin irritation test (patch test) shows that there is no irritation reaction on sensitive skin and eczema skin, and it is suitable for postoperative population.

[0034] Further, the mass percentage of tea tree oil in the moisturizing and repairing type hand sanitizer is 0.3-0.5%, the mass percentage of polylysine hydrochloride in the moisturizing and repairing type hand sanitizer is 0.1-0.2%, and the mass percentage of chitosan in the moisturizing and repairing type hand sanitizer is 0.2-0.3%.

[0035] Further, the moisturizing and skin moistening composition is composed of panthenol, shea butter, sodium hyaluronate and honeysuckle extract.

[0036] Preferably, the sodium hyaluronate is prepared by compounding small molecule sodium hyaluronate and high molecule sodium hyaluronate at a mass ratio of 1:2.

[0037] The molecular weight of the small molecule sodium hyaluronate is 1000-100000 Da (Dalton), and the molecular weight of the high molecule sodium hyaluronate is 1000000-2000000 Da (Dalton).

[0038] The panthenol (vitamin B5) is a small molecule penetration type moisturizing agent, which can repair the skin barrier; the shea butter is a blocking oil, which contains unsaturated fatty acids and can lock water and moisturize; the sodium hyaluronate (high and low molecule compound) has a small molecule to high molecule ratio of 1:2, the small molecule penetrates into the dermis to supply water, and the high molecule locks water on the surface layer; and the honeysuckle extract contains chlorogenic acid and can assist in relieving inflammation.

[0039] The moisturizing and skin moistening composition of the present application forms a synergistic moisturizing and skin moistening system, which has the following advantages:

[0040] 1. Adopting the synergistic mechanism of "penetration-sealing-hydrating": panthenol penetrates and repairs (depth > 200 μm), shea butter seals and locks water (water loss rate is reduced by 40%), and high and low molecular weight sodium hyaluronate constructs a moisturizing network, solving the problem of "watering without locking, locking without repairing" of single moisturizing ingredients;

[0041] 2. The combination of honeysuckle extract and panthenol enhances the soothing effect and avoids skin redness after cleaning.

[0042] Further, the mass percentage of panthenol in the moisturizing and repairing hand sanitizer is 1.5-2%, the mass percentage of shea butter in the moisturizing and repairing hand sanitizer is 1-1.5%, the mass percentage of sodium hyaluronate in the moisturizing and repairing hand sanitizer is 0.1-0.2%, and the mass percentage of honeysuckle extract in the moisturizing and repairing hand sanitizer is 1.5-2%.

[0043] Further, the auxiliary agent consists of xanthan gum and citric acid; the mass percentage of xanthan gum in the moisturizing and repairing hand sanitizer is 0.15-0.2%, and the mass percentage of citric acid in the moisturizing and repairing hand sanitizer is 0.1-0.15%.

[0044] Among them, xanthan gum (viscosity regulator): control the product viscosity in 3000-5000 mPa・s, ensure easy to apply, not clumping; citric acid (pH regulator): adjust the product pH to 5.5-6.0, match the weak acidic environment of skin barrier.

[0045] The auxiliary agent of the present application forms an auxiliary agent optimization system, which has the following advantages:

[0046] 1. Xanthan gum adopts "gradient addition method" (first dissolved in deionized water, then gradually added to other ingredients), which avoids clumping and improves the stability of the formula (no stratification after 45℃ constant temperature storage for 3 months);

[0047] 2. Citric acid adjusts the pH in stages (first adjust the surfactant to 5.8-6.0, then add the antibacterial composition and moisturizing and skin soothing composition, and finally adjust to 5.5-6.0), which ensures the stability of the activity of each component.

[0048] Further, the moisturizing and repairing hand sanitizer consists of the following components in the following mass percentages:

[0049] Surfactant 11-15%, antibacterial composition 0.6-1.0%, moisturizing and skin soothing composition 4.1-5.7%, auxiliary agent 0.25-0.5%, and the balance is deionized water.

[0050] Among them, the deionized water has removed impurity ions, which can avoid additional irritation to sensitive skin.

[0051] The application provides a moisturizing repair type hand washing liquid, which realizes natural, mild, skin care, healthy and multiple advantages through the design of multiple systems such as surface activity, antibiosis, moisturizing and skin moistening.

[0052] In the surface activity system, coconut oil glucoside (APG-12), decyl glucoside (APG-10) and potassium cocoyl glutamate are compounded, 100% derived from nature, no chemical synthesis of surface activity, the combination of amino acid surface activity and non-ionic glucoside has both cleaning power and mildness, meets the needs of natural and organic scenes such as mother and baby, sensitive skin and organic certified products, and the biodegradability is greater than or equal to 98%, the environmental protection is outstanding, and the water pollution problem of traditional surface activity can be avoided.

[0053] In the construction of the antibacterial system, tea tree oil, polylysine hydrochloride and chitosan are innovatively compounded, tea tree oil can quickly inhibit surface pathogenic bacteria to bring immediate antibacterial effect, polylysine hydrochloride can strengthen the inhibition of stubborn bacteria such as staphylococcus aureus and prolong the antibacterial time, and chitosan can form an antibacterial film to reduce the secondary adhesion of bacteria, and also assists in moisturizing, and the three are synergistic to realize efficient antibiosis from different aspects.

[0054] In the construction of the moisturizing and skin moistening system, panthenol, shea butter and sodium hyaluronate are compounded, panthenol can deeply moisturize and repair the skin barrier, shea butter can seal water and relieve dryness, and sodium hyaluronate (low molecular weight + high molecular weight compound) realizes the dual effects of moisturizing and water locking, the effects of the components are complementary and synergistic, the skin moisturizing and repairing needs are accurately and comprehensively met, and the overall skin care effect is improved.

[0055] In addition, xanthan gum is reasonably matched as a viscosity regulator, citric acid is reasonably matched as a pH regulator, and deionized water is combined, so that the product performs better in use feeling and stability, and multiple advantages such as naturalness, mildness, skin care and health are realized, and a better skin care experience is provided for consumers. DETAILED DESCRIPTION

[0056] The technical solutions in the embodiments of the application will be described below in a clear and complete manner. Obviously, the described embodiments are part of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the application.

[0057] It should be understood that when used in the specification and the appended claims, the terms "comprise" and "include" indicate the existence of the described features, integers, steps, operations, elements, and / or components, but do not exclude one or more other features, integers, steps, operations, elements, components, and / or sets thereof.

[0058] It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the present application. As used in this specification and the appended claims, the singular forms "a," "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

[0059] It is to be further understood that the term "and / or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items, and that the term "at least one of' encompasses any and all possible combinations of one or more of the associated listed items.

[0060] For a more complete understanding of the present application, the technical solutions of the present application are further introduced and described below in combination with specific embodiments.

[0061] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0062] Unless otherwise specified, the percentages of the components in the present application are mass percentages, and the proportions of the components used in the present application are mass ratios.

[0063] In the present application, the molecular weight of the small-molecule sodium hyaluronate used in the examples and comparative examples is 1000 Da (Dalton), and the molecular weight of the high-molecule sodium hyaluronate is 1000000 Da (Dalton).

[0064] Around the three core innovations of "surface active system ratio optimization", "antibacterial ingredient synergistic effect" and "moisturizing skin care ingredient dosage adaptation", 6 groups of examples and 3 groups of comparative examples are designed by controlling a single variable (such as the dosage of a certain component, whether to add a certain component), combined with quantitative test data (cleaning rate, antibacterial rate, moisturizing property, etc.), to verify the creativity and synergistic effect of the present application. All examples / comparative examples are calculated based on 100 g total mass, and the basic adjuvant (xanthan gum 0.2%, citric acid 0.15%, deionized water to 100%) remains the same.

[0065] Preparation method of hand sanitizer:

[0066] I. Xanthan gum pre-dissolution (to ensure formula stability)

[0067] Take deionized water with a total mass dosage of 50% and add it to the reaction kettle, start stirring (speed 250 r / min), add xanthan gum 0.2 g (0.2% of the total mass of the finished product), stir while adding, continue stirring for 15 minutes until the xanthan gum is completely dissolved and there are no lumps, forming a uniform glue liquid, then cool the glue liquid to room temperature (25-30℃) for standby, to avoid the influence of high temperature on the stability of xanthan gum later.

[0068] II. Surfactant dissolution and initial pH adjustment (temperature adjustment to 70°C)

[0069] 1. Add the remaining 50% of deionized water to another reaction kettle, turn on the heating device, and raise the water temperature to 70°C, maintaining the temperature stable (temperature difference ±1°C);

[0070] 2. Add the surfactants in the following order, ensuring complete dissolution at high temperature:

[0071] 3. First, add cocoglycoside, maintain 70°C stirring for 12 minutes, until the powder is completely dissolved and no visible particles are present;

[0072] 4. Then add decyl glucoside, continue stirring at 70°C for 10 minutes to ensure uniformity of the system;

[0073] 5. Finally, add potassium cocoyl glutamate, stir at 70°C for 15 minutes to completely dissolve the surfactant components and form a transparent surfactant solution;

[0074] 6. Turn off the heating device and allow the surfactant solution to naturally cool to 40-45°C (to avoid high temperature damage to the activity of subsequent added ingredients), then add part of the citric acid 0.08g (0.08% of the total mass of the finished product), stir for 5 minutes, and adjust the pH of the system to 5.8-6.0.

[0075] III. Addition of antibacterial composition

[0076] Maintain the temperature of the surfactant solution obtained in step II at 35-40°C (if the temperature is too high, it can be adjusted by passing cooling water through the reactor jacket), and add the antibacterial ingredients in the following order:

[0077] 1. Add tea tree essential oil and stir for 8 minutes to avoid separation of the essential oil under gentle stirring;

[0078] 2. Add polylysine hydrochloride and stir for 8 minutes to ensure uniform dispersion of the polypeptide component;

[0079] 3. Add chitosan 0.25g and stir for 8 minutes until the chitosan is completely swollen without flocculation, while retaining an active ingredient content of ≥95%.

[0080] IV. Mixing of moisturizing and skin-soothing composition and integration with xanthan gum solution

[0081] 1. Reduce the temperature of the system to 30-32°C, and add the moisturizing and skin-soothing ingredients in the following order:

[0082] 2. Add panthenol and stir for 10 minutes until the panthenol is completely dissolved;

[0083] 3. Add shea butter and stir for 12 minutes under low-speed stirring (speed reduced to 200r / min) to avoid uneven emulsification of the oil;

[0084] 4. Add compounded sodium hyaluronate (small molecule: high molecule = 1:2), stir for 15 minutes, and ensure that the high and low molecular weight sodium hyaluronate is uniformly dispersed to form a moisturizing network;

[0085] 5. Add honeysuckle extract, stir for 10 minutes, and fully blend the extract;

[0086] 6. Slowly pump the xanthan gum solution prepared in step one into the reaction kettle while stirring (speed 250 r / min), and continue stirring for 15 minutes to make the system uniform and without stratification.

[0087] Five, final adjustment and filtration (to ensure product compliance)

[0088] 1. Add the remaining 0.07 g of citric acid (0.07% of the total mass of the finished product), stir for 8 minutes, and adjust the pH of the system to 5.5-6.0, while detecting the viscosity (controlled at 3000-5000 mPa·s);

[0089] 2. After stirring, turn off the stirring device, and let the system stand for 30 minutes, and naturally cool to room temperature;

[0090] 3. Filter through a 100-mesh filter to remove possible small impurities or incompletely dissolved particles to obtain the moisturizing and repairing hand sanitizer finished product.

[0091] Performance test:

[0092] 1. Cleaning rate (artificial oil stain, %): According to “QB / T4348-2012”, 10 healthy subjects were smeared with artificial oil stain (pig fat: liquid paraffin: carbon black = 5:3:2) on the back of the hand, and then rubbed with 0.5 g of the moisturizing and repairing hand sanitizer of the present application / Comparative Example for 30 s and washed, and the cleaning rate was calculated by L value of color difference meter;

[0093] 2. Instant antibacterial rate (10 min, %): According to “GB15979” and “QB / T2738”, ATCC standard bacteria (Staphylococcus aureus, Escherichia coli, Candida albicans) were used, and the sample was reacted with the bacterial suspension for 10 min, and then the antibacterial rate was calculated by plate counting;

[0094] 3. 72h long-acting antibacterial rate (%): According to “GB15979” and “QB / T2738”, 10 subjects were cleaned, and the number of bacteria on the hands was measured at 0-72h;

[0095] 4. Test method for stratum corneum moisture (AU) 1h after cleaning and TEWL value (g / h·m²) 1h after cleaning:

[0096] Sample preparation: 20 healthy subjects (age 20-45, half male and half female, no skin disease on hands) were selected, 1 h before the test, avoid washing hands, applying skin care products, enter the test environment for 30 min.

[0097] Test procedure:

[0098] a. Baseline test: mark 3 1 cm x 1 cm test areas on the back of the left hand of the subject, use the tester to determine the stratum corneum moisture of each area respectively, take the average value as the initial moisture value (AU0);

[0099] b. Cleaning operation: take 0.5 g of the hand sanitizer to be tested, rub it on the back of the right hand for 30 s (in the order of "palm-back-finger gap-fingertip"), rinse it with 38±2℃ flowing water for 30 s, and dry it with a sterile paper towel;

[0100] c1. 1 h after test (AU1): 1 h after cleaning, mark 3 test areas on the same position on the back of the right hand, measure the stratum corneum moisture (AU1), and calculate the average value;

[0101] c2. 1 h after test (TEWL1): 1 h after cleaning, measure the TEWL value (TEWL1) in the same area on the back of the right hand, and take the average value;

[0102] d1. Result calculation (AU1): the stratum corneum moisture 1 h after cleaning is represented by the average value of AU1, the higher the value, the better the immediate moisturizing effect;

[0103] d2. Result calculation (TEWL1): the TEWL value 1 h after cleaning is represented by the average value of TEWL1, the lower the value, the stronger the skin barrier water-locking ability.

[0104] 5. Skin irritation incidence rate (%): 30 subjects (including 8 sensitive skin) applied the hand sanitizer sample on the forearm, and observed the skin reaction after 48 h;

[0105] 6. Ceramide destruction rate (%): 10 sensitive skin subjects were cleaned with the hand sanitizer of the example / contrast example, and the stratum corneum ceramide content was measured;

[0106] 7. 28-day ceramide increment (%): 20 dry skin subjects (initial moisture <30 AU, TEWL >15 g / h·m²) used the hand sanitizer 3 times a day for 28 consecutive days to test the ceramide increment;

[0107] 8. Secondary attachment amount (CFU / cm²): 2 h after the 72 h long-term bacteriostatic rate test was completed, the secondary attachment amount was measured on the contact contaminated surface;

[0108] 9. 28-day stratum corneum moisture (AU): 20 dry skin subjects (initial moisture <30 AU, TEWL >15 g / h·m²), 3 times daily with hand sanitizer, for 28 consecutive days, measuring stratum corneum moisture;

[0109] 10. Use feeling score (5-point scale): 30 subjects evaluated the use feeling on a 5-point scale;

[0110] 11. Formula viscosity (mPa・s): 30 samples (50 g per portion, transparent sealed bottle), respectively stored at 4℃ (low temperature), 25℃ (room temperature), and 45℃ (high temperature) for 3 months, observing the appearance, measuring the viscosity (3000-5000 mPa·s), and pH (5.5-6.0) every month;

[0111] 12. Biodegradability (%):

[0112] Test sample: Take the surfactant component in the hand sanitizer to be tested (mixed according to the formula proportion) to prepare a 1000 mg / L aqueous solution as the test solution; glucose (1000 mg / L) is used as the positive control, and deionized water is used as the blank control.

[0113] Test steps:

[0114] a. Inoculation: 100 mL of the test solution is added to the test bottle, and 10 mL of activated sludge (taken from a municipal sewage treatment plant, MLSS = 3000 mg / L) is inoculated, and the test bottle is sealed;

[0115] b. Cultivation: the test bottle is placed in a 25±1℃ constant temperature incubator for continuous cultivation for 28 days, and the daily oxygen consumption (O2) is recorded;

[0116] c. Calculation: biodegradability (%) = (actual oxygen consumption of the test solution / theoretical oxygen consumption) × 100%, and the theoretical oxygen consumption is calculated according to the carbon content of the surfactant;

[0117] d. Result determination: biodegradability ≥90% is considered to be easily biodegradable, and the present application requires ≥98%.

[0118] 13. Antimicrobial film thickness (μm):

[0119] Test steps:

[0120] a. Sample smearing: 0.1 g of the hand sanitizer to be tested is evenly smeared on the surface of the pig skin (area 2 cm×2 cm), and the antimicrobial film is formed after being placed at 25℃ and 50% relative humidity for 30 min;

[0121] b. AFM test: the pig skin is fixed on the sample stage, and the light tapping mode is scanned with a scanning range of 5 μm×5 μm, the three-dimensional topography of the antimicrobial film is obtained, the thickness of 5 different positions is measured, and the average value is taken.

[0122] c. Results indicate: antibacterial film thickness in μm, the invention requires thickness of about 5-10 μm.

[0123] Example 1

[0124] The moisturizing repair type hand sanitizer of Example 1 was prepared according to the formulation of Table 1

[0125] Table 1 Formulation of the moisturizing repair type hand sanitizer of Example 1

[0126]

[0127] Example 1 was tested for performance, and the test results are shown in Table 2:

[0128] Table 2 Performance test results of the formulation of the moisturizing repair type hand sanitizer of Example 1

[0129]

[0130] Example 2

[0131] The moisturizing repair type hand sanitizer of Example 2 was prepared according to the formulation of Table 3

[0132] Table 3 Formulation of the moisturizing repair type hand sanitizer of Example 2

[0133]

[0134] Example 2 differs from Example 1 in the amount of components in the surfactant, and the rest of the conditions are the same.

[0135] Example 2 was tested for performance, and the test results are shown in Table 4:

[0136] Table 4 Performance test results of the formulation of the moisturizing repair type hand sanitizer of Example 2

[0137]

[0138] Example 3

[0139] The moisturizing repair type hand sanitizer of Example 3 was prepared according to the formulation of Table 5

[0140] Table 5 Formulation of the moisturizing repair type hand sanitizer of Example 3

[0141]

[0142] Example 3 differs from Example 1 in the amount of components in the surfactant, and the rest of the conditions are the same.

[0143] Example 3 was tested for performance, and the test results are shown in Table 6:

[0144] Table 6 Performance test results for the moisturizing repair hand sanitizer formulation of Example 3

[0145]

[0146] Example 4

[0147] Prepare the moisturizing repair hand sanitizer of Example 4 according to the formulation of Table 7

[0148] Table 7 Formulation of the moisturizing repair hand sanitizer of Example 4

[0149]

[0150] Example 4 differs from Example 1 in the amount of components in the moisturizing skin care composition, with all other conditions being the same.

[0151] Example 4 is tested for performance, and the results are shown in Table 8:

[0152] Table 8 Performance test results for the moisturizing repair hand sanitizer formulation of Example 4

[0153]

[0154] Example 5

[0155] Prepare the moisturizing repair hand sanitizer of Example 5 according to the formulation of Table 9

[0156] Table 9 Formulation of the moisturizing repair hand sanitizer of Example 5

[0157]

[0158] Example 5 differs from Example 1 in the amount of components in the moisturizing skin care composition, with all other conditions being the same.

[0159] Example 5 is tested for performance, and the results are shown in Table 10:

[0160] Table 10 Performance test results for the moisturizing repair hand sanitizer formulation of Example 5

[0161]

[0162] Example 6

[0163] Prepare the moisturizing repair hand sanitizer of Example 6 according to the formulation of Table 11

[0164] Table 11 Formulation of the moisturizing repair hand sanitizer of Example 6

[0165]

[0166] Example 6 differs from Example 1 in the amount of components in the moisturizing skin care composition, and the rest of the conditions are the same.

[0167] Example 6 is subjected to performance testing, and the test results are shown in Table 12:

[0168] Table 12 Performance test results of the moisturizing repair type hand sanitizer formula of Example 6

[0169]

[0170] Comparative Example 1

[0171] The moisturizing repair type hand sanitizer of Comparative Example 1 is prepared according to the formula in Table 13

[0172] Table 13 Formula of the moisturizing repair type hand sanitizer of Comparative Example 1

[0173]

[0174] Comparative Example 1 differs from Example 1 in that the surfactant is sodium lauryl sulfate, the antibacterial composition is phenoxyethanol, and the moisturizing skin care composition is glycerin, and the rest of the conditions are the same. Among them, Comparative Example 1 uses traditional sulfate surfactants instead of natural compound surfactants, traditional chemical preservatives instead of triple antibacterial systems, and a single moisturizing agent instead of a synergistic moisturizing and skin care system.

[0175] Comparative Example 1 is subjected to performance testing, and the test results are shown in Table 14:

[0176] Table 14 Performance test results of the moisturizing repair type hand sanitizer formula of Comparative Example 1

[0177]

[0178] From the test results in Tables 2, 4, 6 and 14, it can be seen that the moisturizing repair type hand sanitizer (natural compound) of Examples 1-3 and the moisturizing repair type hand sanitizer (traditional sulfate) of Comparative Example 1 have a great difference in surfactant system. The cleaning rate of Examples 1-3 (natural compound surfactant) is 95.1%-98.2%, which is significantly higher than that of Comparative Example 1 (traditional SLS, 90.5%); the skin irritation rate is 0%-6.7%, which is much lower than that of Comparative Example 1 (30.0%). Conclusion: The compound of "APG-12+APG-10+potassium cocoyl glutamate" achieves synergy in "cleaning power-mildness-environmental protection", breaking through the problem of "cleaning and mildness cannot be achieved simultaneously" and "high efficiency and environmental protection conflict" of traditional surfactants, and its biodegradability is ≥98% through the standard detection of "GB / T15818-2018", which can avoid the water pollution problem of traditional surfactants, and the compound of "non-ionic glucoside+amino acid surfactant" can reduce the damage rate of surfactant to skin lipids (actual damage rate <5%, which is much lower than the 30% of traditional sulfate surfactants).

[0179] Comparative Example 2

[0180] The moisturizing repair type hand sanitizer of Comparative Example 2 was prepared according to the formulation in Table 15

[0181] Table 15 Formulation of the moisturizing repair type hand sanitizer of Comparative Example 2

[0182]

[0183] Comparative Example 2 differs from Example 1 in that the antibacterial composition is only tea tree oil, i.e. a single antibacterial ingredient is used instead of the triple antibacterial system in Example 1, and the rest of the conditions are the same.

[0184] Performance tests were conducted on Comparative Example 2, and the test results are shown in Table 16:

[0185] Table 16 Performance test results of the formulation of the moisturizing repair type hand sanitizer of Comparative Example 2

[0186]

[0187] From the test results in Table 2 and Table 16, it can be seen that the moisturizing repair type hand sanitizer (triple antibacterial) of Example 1 and the moisturizing repair type hand sanitizer (single tea tree oil) of Comparative Example 2 have a large difference in the antibacterial system. The 72h long-acting antibacterial rate of Example 1 (triple antibacterial) is 94.8%, and the secondary adhesion amount is 12±3 CFU / cm²; the 72h antibacterial rate of Comparative Example 2 (single tea tree oil) is only 62.7%, and the secondary adhesion amount is 58±8 CFU / cm². Therefore, the present application constructs a triple synergistic system of "plant source instant antibacterial + microbial source long-acting antibacterial + mineral source protective antibacterial" by using tea tree oil (plant source), polylysine hydrochloride (microbial source) and chitosan (mineral source), and forms a triple antibacterial mechanism of "instant - long-acting - protective". The antibacterial rate of tea tree oil is ≥99% within 10 minutes (instant), the antibacterial time of polylysine hydrochloride is extended to 72 hours (long-acting), and chitosan forms a transparent antibacterial film (thickness of about 5-10 μm) on the skin surface to reduce bacterial secondary adhesion. The present application breaks through the limitations of traditional single antibacterial ingredient "short time, narrow range, and irritation", and is verified by skin irritation test (patch test) to have no irritation reaction on sensitive skin and eczema skin, and is suitable for postoperative population.

[0188] Comparative Example 3

[0189] The moisturizing repair type hand sanitizer of Comparative Example 3 was prepared according to the formulation in Table 17

[0190] Table 17 Formulation of the moisturizing repair type hand sanitizer of Comparative Example 3

[0191]

[0192] The difference between Comparative Example 3 and Example 1 is that the moisturizing skin care composition is only panthenol and the amount is 5.0 g, i.e. a single moisturizing ingredient is used to replace the moisturizing skin care system in Example 1, and the rest of the conditions are the same.

[0193] The performance test of Comparative Example 3 is carried out, and the test results are shown in Table 18:

[0194] Table 18 Performance test results of the moisturizing and repairing hand sanitizer formula of Comparative Example 3

[0195]

[0196] It can be seen from the test results in Table 2 and Table 18 that the moisturizing and repairing hand sanitizer (four-effect synergy) of Example 1 of the present application and the moisturizing and repairing hand sanitizer (single moisturizing ingredient) of Comparative Example 3 have great difference in the moisturizing skin care system. The ceramide increment of Example 1 (synergistic system) is 20.3% in 28 days, and the stratum corneum moisture is 55.8 AU in 28 days; the ceramide increment of Comparative Example 3 (single panthenol) is only 8.5%, and the stratum corneum moisture is 38.2 AU. It can be seen that the present application uses the synergistic mechanism of "penetration-closure-hydrating" by panthenol (penetration repair), shea butter (occlusive water locking), sodium hyaluronate (high and low molecular weight complex moisturizing), honeysuckle extract (anti-inflammatory soothing) - penetration repair (depth ≥ 200 μm), shea butter occlusive water locking (water loss rate reduced by 40%), high and low molecular weight sodium hyaluronate (small molecule: high molecular weight ratio = 1:2) to build a moisturizing network, and to solve the chain problem of "dryness-sensitivity-barrier vulnerability" of the skin after makeup removal / barrier damage. The actual measured ceramide content of the stratum corneum after use is increased by 20%, which improves the integrity of the skin barrier. At the same time, the complex of honeysuckle extract and panthenol can enhance the soothing effect and avoid skin redness after cleaning.

[0197] In summary, the present application provides a moisturizing and repairing hand sanitizer, which has the following beneficial effects:

[0198] 1. Surfactant system innovation: the first "100% natural non-ionic glucoside + amino acid surfactant" complex mass ratio is created, which can achieve efficient cleaning while reducing skin irritation rate to below 7%, and has a biodegradability of ≥98%, which takes into account safety and environmental protection, and solves the problem of "cleaning and mildness cannot be achieved simultaneously" and "high efficiency and environmental protection conflict" of traditional surfactants;

[0199] 2. Anti-bacterial mechanism innovation: a triple synergistic system of "plant source instant antibacterial + microbial source long-term antibacterial + mineral source protective antibacterial" is constructed, which breaks through the limitations of traditional single antibacterial ingredient "short time, narrow range, and irritation", achieves a 72-hour antibacterial rate of ≥93%, and has no irritation to sensitive skin and postoperative population, filling the technical gap of "antibacterial and mild synergy";

[0200] 3. Moisturizing and skin-soothing synergistic innovation: The product adopts a four-effect synergistic design of "penetration repair (panthenol) + sealing and water locking (shea butter) + double hydration (high and low molecular weight sodium hyaluronate) + soothing and anti-inflammatory (honeysuckle extract)", which solves the interlocking problems of "dryness-sensitivity-barrier vulnerability" of skin after makeup removal / barrier damage. The actual measurement shows that the ceramide content in the skin stratum corneum increases by 20% after use, improving the skin barrier integrity.

[0201] 4. Formulation optimization innovation: Through the process means of "gradient addition of xanthan gum" and "staged pH adjustment", combined with deionized water, the compatibility of natural ingredients and the stability of the formula are ensured, solving the technical pain points of natural formula such as "easy stratification, uneven viscosity, and easy inactivation of activity". At the same time, the product pH is accurately matched with the skin barrier, further reducing the risk of irritation.

[0202] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present application, and these modifications or replacements should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A moisturizing repair type hand sanitizer, characterized by, Includes the following components by mass percentage: Surfactant 11-15%, antibacterial composition 0.6-1.0%, moisturizing and skin-nourishing composition 4.1-5.7%, additives 0.25-0.5%; The surfactant is composed of cocoyl glucoside, decyl glucoside and potassium cocoyl glutamate; The cocoyl glucoside accounts for 6-8% of the mass of the moisturizing and repairing hand sanitizer, the decyl glucoside accounts for 2-3% of the mass of the moisturizing and repairing hand sanitizer, and the potassium cocoyl glutamate accounts for 3-4% of the mass of the moisturizing and repairing hand sanitizer. The antibacterial composition comprises tea tree oil, polylysine hydrochloride, and chitosan; the moisturizing composition comprises panthenol, shea butter, sodium hyaluronate, and honeysuckle extract; the adjuvants include xanthan gum and / or citric acid. The tea tree essential oil accounts for 0.3-0.5% of the mass of the moisturizing and repairing hand sanitizer, the polylysine hydrochloride accounts for 0.1-0.2% of the mass of the moisturizing and repairing hand sanitizer, and the chitosan accounts for 0.2-0.3% of the mass of the moisturizing and repairing hand sanitizer. The panthenol accounts for 1.5-2% of the mass of the moisturizing and repairing hand sanitizer, the shea butter accounts for 1-1.5% of the mass of the moisturizing and repairing hand sanitizer, the sodium hyaluronate accounts for 0.1-0.2% of the mass of the moisturizing and repairing hand sanitizer, and the honeysuckle extract accounts for 1.5-2% of the mass of the moisturizing and repairing hand sanitizer.

2. The moisturizing repair type hand soap according to claim 1, wherein The mass ratio of the cocoyl glucoside, decyl glucoside and potassium cocoyl glutamate is (6.5-7):(2.5-3):(3-4).

3. The moisturizing and repairing hand sanitizer as described in claim 1, characterized in that, The additives consist of xanthan gum and citric acid; the xanthan gum accounts for 0.15-0.2% of the mass of the moisturizing and repairing hand sanitizer, and the citric acid accounts for 0.1-0.15% of the mass of the moisturizing and repairing hand sanitizer.

4. The moisturizing and repairing hand sanitizer as described in claim 1, characterized in that, Composed of the following components by mass percentage: Surfactant 11-15%, antibacterial composition 0.6-1.0%, moisturizing composition 4.1-5.7%, auxiliary agent 0.25-0.5%, balance deionized water.

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