Optimization system for osmotic pressure test of ipratropium bromide solution

Abstract

The invention relates to the technical field of osmotic pressure testing, and particularly discloses an optimization system for osmotic pressure testing of an ipratropium bromide solution, which comprises a data acquisition module, a data processing module and a data processing module, the data recording module records the operation state data of the conductivity acquisition instrument in the use process, and the operation state of the conductivity acquisition instrument directly affects the accuracy of the conductivity data of the standard solution, so that the operation state of the conductivity acquisition instrument can be analyzed based on the data; the conductivity data can be corrected, so that the data is closer to a true value, the reliability of a quality analysis result of a standard solution is improved, the accuracy of a precision detection result of an osmotic pressure detection instrument and an osmotic pressure detection result of an ipratropium bromide solution is further improved, and the optimization of an osmotic pressure detection method is realized.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of osmotic pressure testing, in particular to an optimization system for osmotic pressure testing of ipratropium bromide solution. BACKGROUND

[0002] Since ipratropium bromide solution is usually administered by nebulization inhalation or intravenous injection, and both too high and too low osmotic pressure of ipratropium bromide solution can cause adverse reactions, in order to avoid this situation, it is necessary to test the osmotic pressure of ipratropium bromide solution.

[0003] The traditional osmotic pressure testing method of ipratropium bromide solution is generally based on osmotic pressure testing instrument using freezing point depression method to indirectly measure osmotic pressure molar concentration by measuring solution freezing point depression value, and before measurement, national secondary standard substance such as sodium chloride standard solution will be selected first, and the quality of standard solution will be analyzed, and under the condition of ensuring the quality of standard solution, the precision of osmotic pressure testing instrument will be calibrated based on standard solution to ensure the testing accuracy of osmotic pressure testing instrument.

[0004] In the traditional osmotic pressure testing process, the precision of osmotic pressure testing instrument is calibrated based on standard solution, and before that, the quality of standard solution is analyzed based on the physical property parameters of standard solution, but the collected data physical property parameters can be affected by various factors to cause false low, thereby reducing the reliability of standard solution quality analysis results, and further affecting the reliability of osmotic pressure testing instrument precision detection results and the accuracy of ipratropium bromide solution osmotic pressure testing results. SUMMARY

[0005] The purpose of the present application is to provide an optimization system for osmotic pressure testing of ipratropium bromide solution, which solves the following technical problems: How to ensure the accuracy of the osmotic pressure testing results of ipratropium bromide solution.

[0006] The purpose of the present application can be achieved by the following technical solutions: An optimization system for osmotic pressure testing of ipratropium bromide solution, the system comprises: A data acquisition module for acquiring the physical property parameters of standard solution to be used by osmotic pressure testing instrument during calibration, including standard solution conductivity; A data recording module for recording the running state data of conductivity acquisition instrument during use; A data correction module for correcting the standard solution conductivity data in combination with the data recorded in the data set recording module; The data evaluation module is used to analyze the quality of the standard solution by combining the corrected conductivity data of the standard solution with the physical property parameters of the standard solution acquired by the data acquisition module. The data analysis module is used to combine the state analysis results of the standard solution to further calibrate the osmotic pressure testing instrument, and to determine whether the accuracy of the osmotic pressure testing instrument can be used to detect the osmotic pressure of ipratropium bromide solution based on the calibration results.

[0007] Furthermore, the data collected by the data acquisition module includes: Conductivity, pH value, and suspended solids content of the standard solution; The data recorded by the data recording module includes: The conductivity acquisition instrument's temperature compensation element status data and lead oxide area during use; The conductivity acquisition instrument's temperature compensation element status data during use also includes the temperature compensation element's resistance, response time, and operating voltage value.

[0008] Furthermore, the correction process of the data correction module includes: S1: By combining the temperature compensation element status data during the use of the conductivity acquisition instrument, the operating status influence index of the temperature compensation element is calculated. S2: By comparing the operating status impact index of the temperature compensation element with the preset operating status impact index threshold, it is determined whether there is any abnormality in the temperature compensation element based on the comparison result. S3: When it is determined that there is an abnormality in the temperature compensation element, the lead oxidation area data is introduced to correct the conductivity data of the collected standard solution.

[0009] Furthermore, the calculation process in S1 includes: Through formula Calculate the influence index of the operating status of the temperature compensation element during a single data acquisition. ; in, This represents the resistance value of the temperature compensation element in the conductivity acquisition instrument during a single data acquisition. The preset resistance value, For ambient temperature, for The standard value, for The standard value, For the response time of the temperature compensation element, The preset response time, The operating voltage of the temperature compensation element. The preset operating voltage, for The standard value.

[0010] Furthermore, the judgment process in S32 includes: By influencing the index through the operating status of the temperature compensation element during a single data acquisition. Impact of preset operating state on the index threshold Perform a comparison; like The system determines that the temperature compensation element is not functioning properly during data acquisition, which may cause the conductivity data of the acquired standard solution to be lower than the actual value. like The system determines that the temperature compensation element is not in abnormal operation during data acquisition and will not affect the size of the conductivity data of the acquired standard solution.

[0011] Furthermore, the correction process in S3 includes: Through formula The corrected standard solution conductivity was calculated during a single data acquisition. ; in, The conductivity of the standard solution actually collected during a single data acquisition session. The total cross-sectional area of ​​the conductors in the conductivity acquisition instrument. This represents the oxide area of ​​the leads of the conductivity acquisition instrument. and The weighting coefficients are set based on empirical fitting. This is a function for adjusting the coefficient lookup table.

[0012] Furthermore, the evaluation process of the data evaluation module includes: Through formula Calculate the influence coefficient of the standard solution's mass during a single data acquisition. ; in, The conductivity preset for the standard solution, for The standard value, The pH value of the standard solution during a single data acquisition. The preset pH value, for The standard value, This represents the suspended solids content in the standard solution during a single data acquisition. The preset suspended solids content, for The standard value, To define a function, if Then let Otherwise, let .

[0013] Further, the evaluation process of the data evaluation module further comprises: By comparing the solution quality influence coefficient of the standard solution during one data acquisition With the preset solution quality influence coefficient threshold ; If , the system judges that the quality of the standard solution for calibration is poor and needs to be replaced; If , the system judges that the quality of the standard solution for calibration is high and can be calibrated.

[0014] Further, the analysis process of the data analysis module comprises: When it is judged that the quality of the standard solution for calibration is high, the osmotic pressure testing instrument is calibrated, including continuously measuring the osmotic pressure of the standard solution through the osmotic pressure testing instrument multiple times, and recording the results of each measurement; Then the dispersion coefficient of the osmotic pressure of the standard solution is calculated by the formula ; ; Wherein, i is any one osmotic pressure measurement of the osmotic pressure testing instrument on the standard solution, n is the total number of osmotic pressure measurements of the osmotic pressure testing instrument on the standard solution, is the osmotic pressure value of the standard solution measured by the osmotic pressure testing instrument for the i-th time, is the average value of all .

[0015] Further, the analysis process of the data analysis module further comprises: By comparing the dispersion coefficient of the osmotic pressure of the standard solution With the preset dispersion coefficient threshold ; If , the system judges that the difference between all the measurement values in one calibration process of the osmotic pressure testing instrument is small, indicating that the measurement accuracy of the osmotic pressure testing instrument is high, and can be used for detecting the osmotic pressure of ipratropium bromide solution; If , the system judges that the difference between all the measurement values in one calibration process of the osmotic pressure testing instrument is large, indicating that the measurement accuracy of the osmotic pressure testing instrument is general, and a high-precision osmotic pressure testing instrument needs to be replaced.

[0016] The beneficial effects of the present application are: (1) The present invention records the operating status data of the conductivity acquisition instrument during use through the data recording module. Since the operating status of the conductivity acquisition instrument directly affects the accuracy of the conductivity data of the standard solution, the operating status of the conductivity acquisition instrument can be analyzed based on this data, and the conductivity data can also be corrected to make the data closer to the true value, thereby improving the reliability of the standard solution quality analysis results and further improving the accuracy of the osmotic pressure testing instrument's precision detection results and the osmotic pressure testing results of ipratropium bromide solution, thereby optimizing the osmotic pressure testing method.

[0017] (2) By calculating the operating status influence index of the temperature compensation element, this invention can analyze whether there is an abnormality in the operation of the temperature compensation element. Since the temperature compensation element is faulty, it will cause a large difference between the actual temperature and the compensation temperature, which will lead to the measured conductivity value being lower than the true value. Therefore, when it is determined that there is an abnormality in the temperature compensation element, the conductivity data of the collected standard solution can be corrected by introducing the lead oxidation area data, which can improve the reliability of the conductivity data and make it closer to the true value, thereby providing reliable data support for the subsequent analysis of the quality of the standard solution and ensuring the reliability of the analysis results.

[0018] (3) The present invention affects the index by the operating state of the temperature compensation element during a single data acquisition. Impact of preset operating state on the index threshold By comparing the data, we can accurately determine whether there are any abnormalities in the operating status of the temperature compensation element during a single data acquisition. Since a malfunction in the temperature compensation element can lead to a large difference between the actual temperature and the compensated temperature, based on this analysis, we can further determine whether the operating status of the temperature compensation element will cause the measured conductivity value to be lower than the true value. This provides reliable data support for the subsequent correction of the conductivity of the standard solution, ensuring the reliability of the correction results.

[0019] (4) This invention uses the influence coefficient of the solution mass of the standard solution during a single data acquisition. Compared with the preset solution quality influence coefficient threshold By comparing the data, the solution quality of the standard solution used for calibration can be accurately analyzed. Since the conductivity data in this data is obtained based on diversified data correction, the accuracy and reliability of the data are high. Therefore, calculations based on this data can improve the accuracy of the calculation results of the influence coefficient of the solution quality of the standard solution during a single data acquisition, thereby improving the reliability of the judgment results and the reliability of the accuracy test results of the osmotic pressure testing instrument.

[0020] (5) This invention uses the dispersion coefficient of the osmotic pressure of the standard solution. a preset discrete coefficient threshold value The comparison is performed, and through the comparison, the size of the difference between all the measurement values in a calibration process of the osmotic pressure testing instrument can be accurately analyzed. The data can reflect the measurement accuracy of the osmotic pressure testing instrument, so that the osmotic pressure testing instrument is screened to ensure that the subsequent testing of the osmotic pressure of the ipratropium bromide solution is based on a high-precision osmotic pressure testing instrument, so as to optimize the osmotic pressure testing method and ensure the accuracy of the osmotic pressure testing result of the ipratropium bromide solution. BRIEF DESCRIPTION OF DRAWINGS

[0021] The application will be further described below with reference to the drawings.

[0022] Figure 1 is a schematic diagram of an osmotic pressure testing optimization system for an ipratropium bromide solution in the application; Figure 2 is a flowchart of a correction process of a data correction module in the application. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the drawings in the embodiments of the application. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments of the application. Based on the embodiments in the application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the application.

[0024] Please refer to Figure 1 In one embodiment, the application provides an osmotic pressure testing optimization system for an ipratropium bromide solution, as shown in the accompanying drawings, which comprises: a data acquisition module, configured to acquire physical property parameters of a standard solution to be used by an osmotic pressure testing instrument during calibration, including conductivity of the standard solution; a data recording module, configured to record running state data of the conductivity acquisition instrument during use; a data correction module, configured to correct the conductivity data of the standard solution in combination with the recorded data in the data set recording module; a data evaluation module, configured to analyze the quality of the standard solution in combination with the corrected conductivity data of the standard solution and the physical property parameters of the standard solution acquired by the data acquisition module; a data analysis module, configured to further calibrate the osmotic pressure testing instrument in combination with the state analysis result of the standard solution, and determine whether the accuracy of the osmotic pressure testing instrument can be used to detect the osmotic pressure of the ipratropium bromide solution according to the calibration result; Through the technical solution, the data acquisition module is provided for collecting the physical property parameters of the standard solution to be used by the osmotic pressure testing instrument during calibration, including the conductivity of the standard solution, and the data recording module is provided for recording the running state data of the conductivity acquisition instrument during use. When the system is used, the data correction module is combined with the data recorded in the data set recording module to correct the standard solution conductivity data, and then the data evaluation module is combined with the corrected standard solution conductivity data and the physical property parameters of the standard solution collected by the data acquisition module to analyze the quality of the standard solution, and finally the data analysis module is combined with the state analysis result of the standard solution to further calibrate the osmotic pressure testing instrument, and according to the calibration result, it is judged whether the precision of the osmotic pressure testing instrument can be used for detecting the osmotic pressure of ipratropium bromide solution. By so setting, the running state data of the conductivity acquisition instrument during use is recorded by the data recording module. Since the running state of the conductivity acquisition instrument directly affects the accuracy of the standard solution conductivity data, based on the data, not only the running state of the conductivity acquisition instrument can be analyzed, but also the conductivity data can be corrected, so that the data is closer to the true value, thereby improving the reliability of the standard solution quality analysis result, and further improving the accuracy of the osmotic pressure testing instrument precision detection result and the osmotic pressure testing result of ipratropium bromide solution, so as to realize the optimization of the osmotic pressure testing method.

[0025] The data collected by the data acquisition module includes: The conductivity, pH value and suspended solids content of the standard solution; The data recorded by the data recording module includes: The temperature compensation element state data and lead oxidation area of the conductivity acquisition instrument during use; The temperature compensation element state data of the conductivity acquisition instrument during use further includes the resistance, response time and running voltage value of the temperature compensation element; Through the technical solution, the data collected by the data acquisition module and the data recorded by the data recording module are provided, wherein the data collected by the data acquisition module includes the conductivity, pH value and suspended solids content of the standard solution, which can directly reflect whether the quality of the standard solution is qualified; The data recorded by the data recording module includes temperature compensation element state data of the conductivity acquisition instrument in use and lead oxidation area, and the temperature compensation element state data includes resistance, response time and operating voltage value of the temperature compensation element, which can reflect whether the temperature compensation element is abnormal or faulty. When the temperature compensation element is faulty, the actual temperature and the compensation temperature will be greatly different, and the measured conductivity value will be lower than the true value. The larger the lead oxidation area is, the more the electrode area or conductivity will be changed, resulting in lower reading. Therefore, based on the data, the data of the conductivity of the standard solution in the data acquisition module can be corrected, thereby improving the accuracy of the data and the reliability of the subsequent analysis results of the standard solution.

[0026] Please refer to Figure 2 The correction process of the data correction module includes: S1: obtaining an operating state influence index of the temperature compensation element by combining the temperature compensation element state data of the conductivity acquisition instrument in use; S2: comparing the operating state influence index of the temperature compensation element with a preset operating state influence index threshold, and determining whether the temperature compensation element is abnormal according to the comparison result; S3: when it is determined that the temperature compensation element is abnormal, introducing the lead oxidation area data to correct the collected conductivity data of the standard solution; Through the above technical solution, the correction process of the data correction module is provided. First, the operating state influence index of the temperature compensation element is obtained by combining the temperature compensation element state data of the conductivity acquisition instrument in use. Then, the operating state influence index of the temperature compensation element is compared with the preset operating state influence index threshold, and whether the temperature compensation element is abnormal is determined according to the comparison result. When it is determined that the temperature compensation element is abnormal, the lead oxidation area data is introduced to correct the collected conductivity data of the standard solution. Through such a setting, the operating state influence index of the temperature compensation element is obtained, so that whether the temperature compensation element is abnormal can be analyzed. When the temperature compensation element is faulty, the actual temperature and the compensation temperature will be greatly different, and the measured conductivity value will be lower than the true value. Therefore, when it is determined that the temperature compensation element is abnormal, the lead oxidation area data is introduced to correct the collected conductivity data of the standard solution, so as to improve the reliability of the conductivity data and make it closer to the true value, thereby providing reliable data support for subsequent analysis of the quality of the standard solution and ensuring the reliability of the analysis results.

[0027] The calculation process in S1 includes: The formula is The running state influence index of the temperature compensation element in the one-time data acquisition is calculated ; wherein, is the resistance value of the temperature compensation element in the conductivity acquisition instrument in the one-time data acquisition, is a preset resistance value, is the ambient temperature, is a standard value, is a standard value, which can be set according to the allowable error in empirical data, is the response time of the temperature compensation element, is a preset response time, is the running voltage of the temperature compensation element, is a preset running voltage, is a standard value, which can be set according to the allowable error in empirical data; According to the technical scheme, the running state influence index of the temperature compensation element in the one-time data acquisition is provided , which is calculated by the formula , wherein the formula is used to calculate the resistance value of the temperature compensation element corresponding to the ambient temperature in the one-time data acquisition (the calculation formula is prior art and will not be described in detail here). Obviously, when the difference between the resistance value of the temperature compensation element in the one-time data acquisition and the resistance value of the temperature compensation element corresponding to the ambient temperature is greater, the difference between the running voltage of the temperature compensation element and the preset running voltage is greater, and the response time is longer, the running state influence index of the temperature compensation element in the one-time data acquisition is greater, which indicates that the running state of the temperature compensation element in the one-time data acquisition is abnormal. Conversely, when the difference between the resistance value of the temperature compensation element in the one-time data acquisition and the resistance value of the temperature compensation element corresponding to the ambient temperature is smaller, the difference between the running voltage of the temperature compensation element and the preset running voltage is smaller, and the response time is shorter, the running state influence index of the temperature compensation element in the one-time data acquisition is smaller, which indicates that the running state of the temperature compensation element in the one-time data acquisition is normal. Through this calculation method, the state of the temperature compensation element can be analyzed based on diversified data, thereby providing additional data support for subsequent correction of the standard solution conductivity, so as to ensure the reliability of the correction result.

[0028] The judgment process in S32 includes: The running state influence index of the temperature compensation element in the one-time data acquisition is compared with a preset running state influence index threshold value Perform a comparison; like The system determines that the temperature compensation element is not functioning properly during data acquisition, which may cause the conductivity data of the acquired standard solution to be lower than the actual value. like The system determines that the temperature compensation element is not in abnormal operation during data acquisition and will not affect the size of the conductivity data of the acquired standard solution. Through the above technical solution, this example demonstrates how the operating status of the temperature compensation element affects the index during a single data acquisition. Impact of preset operating state on the index threshold By comparing the data, we can accurately determine whether there are any abnormalities in the operating status of the temperature compensation element during a single data acquisition. Since a malfunction in the temperature compensation element can lead to a large difference between the actual temperature and the compensated temperature, based on this analysis, we can further determine whether the operating status of the temperature compensation element will cause the measured conductivity value to be lower than the true value. This provides reliable data support for the subsequent correction of the conductivity of the standard solution, ensuring the reliability of the correction results.

[0029] The correction process in S3 includes: Through formula The corrected standard solution conductivity was calculated during a single data acquisition. ; in, The conductivity of the standard solution actually collected during a single data acquisition session. The total cross-sectional area of ​​the conductors in the conductivity acquisition instrument. This represents the oxide area of ​​the leads of the conductivity acquisition instrument. and The weighting coefficients are set based on empirical fitting. The adjustment coefficient lookup table function is used to determine the values ​​of the adjustment coefficient lookup table function based on empirical data. numerical value or The influence of the range of numerical values ​​on the conductivity of the standard solution was obtained based on testing. Using the above technical solution, this example provides the corrected standard solution conductivity during a single data acquisition. It can be done through the formula The calculation method is based on multiple data sources, including the oxide area of ​​the lead wire and the operating status of the temperature compensation element, to correct the reading. Specifically, when the temperature compensation element malfunctions, it can cause a large difference between the actual temperature and the compensated temperature, resulting in a lower measured conductivity value than the true value. A larger oxide area of ​​the lead wire can change the electrode area or conductivity, leading to a lower reading. Therefore, by integrating multi-dimensional data, this calculation method can improve the reliability of the correction results, thereby providing accurate data for subsequent analysis of the standard solution quality and ensuring the reliability of the analytical results.

[0030] The evaluation process of the data evaluation module includes: Through formula Calculate the influence coefficient of the standard solution's mass during a single data acquisition. ; in, The conductivity preset for the standard solution, for The standard value, The pH value of the standard solution during a single data acquisition. The preset pH value, for The standard value, This represents the suspended solids content in the standard solution during a single data acquisition. The preset suspended solids content, for The standard value mentioned above can be selected and set based on the allowable error in empirical data. To define a function, if Then let Otherwise, let ; Through the above technical solution, this example provides the solution mass influence coefficient of the standard solution during a single data acquisition. It can be done through the formula Calculations show that, obviously, the greater the difference between the corrected conductivity and the preset conductivity of the standard solution during a single data acquisition, the greater the difference between the pH value and the preset pH value of the standard solution, and the greater the suspended solids content in the standard solution is than the preset value, then the solution mass influence coefficient of the standard solution during a single data acquisition... The higher the value, the worse the quality of the standard solution, indicating that it needs to be replaced. Conversely, the smaller the difference between the corrected conductivity and the preset conductivity, the smaller the difference between the pH value and the preset pH value, and the lower the suspended solids content in the standard solution compared to the preset value, the lower the influence coefficient of the standard solution's quality during a single data acquisition. The lower the value, the higher the quality of the standard solution. This calculation method allows for the analysis of the standard solution quality based on diverse data, thereby improving the reliability of the standard solution when analyzing the accuracy of osmotic pressure testing instruments and ensuring the reliability of the analytical results.

[0031] The evaluation process of the data evaluation module also includes: By using the solution mass influence coefficient of the standard solution during a single data acquisition Compared with the preset solution quality influence coefficient threshold Perform a comparison; like The system determines that the standard solution used for calibration is of poor quality and needs to be replaced. like The system determines that the standard solution used for calibration is of high quality and can be used for calibration. Using the above technical solution, this example demonstrates the influence coefficient of the standard solution's mass during a single data acquisition. Compared with the preset solution quality influence coefficient threshold By comparing the data, the solution quality of the standard solution used for calibration can be accurately analyzed. Since the conductivity data in this data is obtained based on diversified data correction, the accuracy and reliability of the data are high. Therefore, calculations based on this data can improve the accuracy of the calculation results of the influence coefficient of the solution quality of the standard solution during a single data acquisition, thereby improving the reliability of the judgment results and the reliability of the accuracy test results of the osmotic pressure testing instrument.

[0032] The analysis process of the data analysis module includes: When the quality of the standard solution used for calibration is determined to be high, the osmotic pressure testing instrument is calibrated, including measuring the osmotic pressure of the standard solution multiple times continuously using the osmotic pressure testing instrument and recording the results of each measurement. Then through the formula Calculate the coefficient of variation of the osmotic pressure of the standard solution. ; Where i represents any single osmotic pressure measurement of the standard solution by the osmotic pressure testing instrument, and n represents the total number of osmotic pressure measurements of the standard solution by the osmotic pressure testing instrument. The osmotic pressure of the standard solution is the value measured by the osmotic pressure testing instrument during the i-th measurement of the standard solution. For all The average value; Through the above technical solution, this example provides the dispersion coefficient of the osmotic pressure of the standard solution. It can be done through the formula The fluctuation value of the osmotic pressure of the standard solution obtained by each measurement in one calibration operation is obtained through the calculation, and the data reflects the fluctuation between each measurement result, and based on the data, the measurement accuracy and stability of the osmotic pressure testing instrument can be analyzed.

[0033] The analysis process of the data analysis module further comprises: The discrete coefficient of the osmotic pressure of the standard solution is compared with the preset discrete coefficient threshold value . If , the system judges that the difference between all the measurement values in one calibration process of the osmotic pressure testing instrument is small, indicating that the measurement accuracy of the osmotic pressure testing instrument is high, and the osmotic pressure testing instrument can be used for detecting the osmotic pressure of ipratropium bromide solution. If , the system judges that the difference between all the measurement values in one calibration process of the osmotic pressure testing instrument is large, indicating that the measurement accuracy of the osmotic pressure testing instrument is general, and a high-precision osmotic pressure testing instrument needs to be replaced. Through the above technical solution, the discrete coefficient of the osmotic pressure of the standard solution is compared with the preset discrete coefficient threshold value , and through the comparison, the difference between all the measurement values in one calibration process of the osmotic pressure testing instrument can be accurately analyzed, and the data can reflect the measurement accuracy of the osmotic pressure testing instrument, so as to realize the screening of the osmotic pressure testing instrument, to ensure that the subsequent osmotic pressure of ipratropium bromide solution is tested based on a high-precision osmotic pressure testing instrument, to realize the optimization of the osmotic pressure testing method, and to ensure the accuracy of the osmotic pressure testing result of ipratropium bromide solution.

[0034] The above describes one embodiment of the present application in detail, but the content is only the preferred embodiment of the present application, and cannot be considered as limiting the scope of the present application. Any equivalent changes and improvements made according to the scope of the present application should still belong to the patent coverage of the present application.

Claims

1. A system for optimizing osmolarity testing of ipratropium bromide solutions, characterized by, The system comprises: a data acquisition module for acquiring physical property parameters of a standard solution to be used by the osmotic pressure testing instrument during calibration, including conductivity of the standard solution; a data recording module for recording running state data of the conductivity acquisition instrument during use; a data correction module for correcting the conductivity data of the standard solution in combination with the recorded data in the data set recording module; a data evaluation module for analyzing the quality of the standard solution in combination with the corrected conductivity data of the standard solution and the physical property parameters of the standard solution acquired by the data acquisition module; a data analysis module for further calibrating the osmotic pressure testing instrument in combination with the state analysis result of the standard solution, and judging whether the precision of the osmotic pressure testing instrument can be used for detecting the osmotic pressure of ipratropium bromide solution according to the calibration result.

2. A system for optimizing the osmolarity test of an ipratropium bromide solution according to claim 1, characterized in that, The data acquired by the data acquisition module includes: conductivity, pH value and suspended matter content of the standard solution; The data recorded by the data recording module includes: temperature compensation element state data and lead oxidation area of the conductivity acquisition instrument during use; The temperature compensation element state data of the conductivity acquisition instrument during use further includes resistance, response time and running voltage value of the temperature compensation element.

3. A system for optimizing osmolarity testing of an ipratropium bromide solution as claimed in claim 1, wherein, The correction process of the data correction module includes: S1: calculating and obtaining an operating state influence index of the temperature compensation element by combining the temperature compensation element state data of the conductivity acquisition instrument during use; S2: comparing the operating state influence index of the temperature compensation element with a preset operating state influence index threshold value, and judging whether the temperature compensation element is abnormal according to the comparison result; S3: when it is judged that the temperature compensation element is abnormal, introducing the lead oxidation area data to correct the acquired conductivity data of the standard solution.

4. A system for optimizing the osmolality check of an ipratropium bromide solution according to claim 3, characterized in that, The calculation process in S1 includes: The running state influence index of the temperature compensation element during the first data acquisition is calculated by the formula ;​ wherein is the resistance value of the temperature compensation element in the conductivity acquisition instrument at the time of the data acquisition, is a preset resistance value, is the ambient temperature, is the standard value of , is the standard value of , is the response time of the temperature compensation element, is a preset response time, is the operating voltage of the temperature compensation element, is a preset operating voltage, is the standard value of .

5. A system for optimizing the osmolarity check of an ipratropium bromide solution according to claim 4, characterized in that, The judgment process in S32 includes: by comparing the operating state influence index of the temperature compensation element at the time of the first data acquisition with a preset operating state influence index threshold value a comparison is made; If , the system determines that the operating state of the temperature compensation element is abnormal during data collection, which will result in the collected conductivity data of the standard solution being lower than the actual value; If , the system determines that the operating state of the temperature compensation element during data collection is not abnormal and will not affect the conductivity data size of the collected standard solution.

6. A system for optimizing the osmolarity test of an ipratropium bromide solution according to claim 5, characterized in that, The correction process in S3 includes: The conductivity of the standard solution after correction at the first data acquisition is calculated by the formula ;​ wherein, is the actual conductivity of the standard solution obtained during the data collection, is the total area of the leads of the conductivity acquisition instrument, is the oxidized area of the leads of the conductivity acquisition instrument, and is the weight coefficient, which is set according to empirical fitting, is the adjustment coefficient table function.

7. A system for optimizing the osmolarity check of an ipratropium bromide solution according to claim 6, characterized in that The evaluation process of the data evaluation module includes: The solution mass influence coefficient of the standard solution in the first data acquisition is calculated by the formula ;​ wherein, the conductivity preset for the standard solution, is the standard value of, the pH value of the standard solution at one data acquisition, is the preset pH value, is the standard value of, the content of suspended matter in the standard solution at one data acquisition, is the preset content of suspended matter, is the standard value of, is a defined function, if then , otherwise .

8. A system for optimizing the osmolarity check of an ipratropium bromide solution according to claim 7, characterized in that, The evaluation process of the data evaluation module further includes: By comparing the solution mass influence coefficient of the standard solution during the first data acquisition with the preset solution mass influence coefficient threshold ; If , the system determines that the quality of the standard solution for calibration is poor and needs to be replaced; If , the system determines that the quality of the standard solution for calibration is high, and calibration can be performed.

9. A system for optimizing the osmolarity check of a solution of ipratropium bromide according to claim 8, characterized in that, The analysis process of the data analysis module includes: when it is judged that the quality of the standard solution used for calibration is high, calibrating the osmotic pressure testing instrument, including continuously measuring the osmotic pressure of the standard solution by the osmotic pressure testing instrument for multiple times, and recording the result of each measurement; The osmolarity of the standard solution is then calculated by the formula and the dispersion coefficient of the osmolarity of the standard solution is obtained ; wherein i is the arbitrary measurement of the osmotic pressure of the standard solution by the osmotic pressure testing instrument, n is the total number of measurements of the osmotic pressure of the standard solution by the osmotic pressure testing instrument, is the osmotic pressure value of the standard solution in the i-th measurement by the osmotic pressure testing instrument, is the average value of all .

10. A system for optimizing the osmolarity check of an ipratropium bromide solution according to claim 9, characterized in that, The analysis process of the data analysis module further includes: By comparing the discrete coefficient of the osmotic pressure of the standard solution with a preset discrete coefficient threshold value performing the comparison; If , the system determines that the difference between all the measurement values in a calibration process of the osmotic pressure testing instrument is small, indicating that the measurement accuracy of the osmotic pressure testing instrument is high, and the osmotic pressure testing instrument can be used for detecting the osmotic pressure of ipratropium bromide solution. If , the system determines that the difference between all the measurement values in a calibration process of the osmotic pressure testing instrument is large, indicating that the measurement accuracy of the osmotic pressure testing instrument is general, and a high-precision osmotic pressure testing instrument needs to be replaced.

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