Shenqi oral liquid for spleen-lung qi deficiency as well as preparation method and application thereof

Abstract

The invention provides radix codonopsis and radix astragali oral liquid for spleen-lung qi deficiency and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine preparations. Radix codonopsis and radix astragali are added with water for heating reflux extraction, and an extracting solution is collected; filtering the extracting solution to obtain a clear filtrate; concentrating the filtrate to obtain fragrant paste; adding xylitol into the fragrant paste, and stirring and dissolving to obtain liquid medicine; after finely filtering the liquid medicine, filling and sealing the liquid medicine into an oral liquid container; and performing terminal sterilization on the filled oral liquid to obtain the Shenqi oral liquid for spleen-lung qi deficiency. The xylitol is used for replacing rock candy, so that the taste modifying requirement is met, more importantly, the product is suitable for diabetics and people needing to control sugar intake, and the applicable people are remarkably expanded; meanwhile, preservatives are completely eliminated, the worry of consumers on chemical additives is eliminated, the product is more natural, safer, accurate in dosage, convenient to open and easy to carry and take, and the medication compliance of patients, especially outgoing patients, is greatly improved.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a ginseng and astragalus oral liquid for spleen and lung qi deficiency, its preparation method and application. Background Technology

[0002] Ginseng and Astragalus Paste (Approval Number: Z32020333) is a classic tonic Chinese medicine. It is made by extracting two medicinal materials, Codonopsis pilosula and Astragalus membranaceus, and then adding rock sugar (sucrose) to make a paste. It has the effect of tonifying the spleen and lungs and is used for spleen and lung qi deficiency syndrome.

[0003] However, existing ginseng and astragalus extract preparations have the following obvious defects: Sugar content issue: The preparation contains a large amount of rock sugar, making it unsafe for diabetic patients, people with abnormal blood sugar, and consumers who pay attention to healthy eating to take it safely, which greatly limits the applicable population.

[0004] Inconvenient to carry and take: Decoctions (pastes) have a viscous texture and need to be taken with a spoon. The dosage is not easy to be accurate, and the packaging container is easily contaminated when opened frequently. They are not convenient to carry and take when traveling or on business trips.

[0005] Contains preservatives: To ensure that the ointment does not deteriorate during storage, the current process requires the addition of an appropriate amount of preservatives, which contradicts the current trend of consumers pursuing "additive-free" natural products.

[0006] Therefore, there is an urgent need in this field for a new formulation that can both retain the efficacy of the original formula and overcome the aforementioned defects. Summary of the Invention

[0007] Technical problem solved: This invention solves the problems of sugar, preservatives, and inconvenience in carrying and taking ginseng and astragalus paste in the prior art.

[0008] Purpose of the invention: This application provides a ginseng and astragalus oral liquid for spleen and lung qi deficiency, its preparation method and application, which is composed of two medicinal materials, ginseng and astragalus, and does not contain sucrose or preservatives.

[0009] To address the problems in the existing technology, the technical solution adopted by this invention is as follows: A ginseng and astragalus oral liquid for spleen and lung qi deficiency, wherein the raw materials of the ginseng and astragalus oral liquid for spleen and lung qi deficiency are formulated in the following mass proportions: 450-550 parts of Codonopsis pilosula, 450-550 parts of Astragalus membranaceus, and 50-150 parts of xylitol.

[0010] Preferably, the raw materials of the ginseng and astragalus oral liquid for spleen and lung qi deficiency are formulated in the following mass proportions: 500 parts of codonopsis, 500 parts of astragalus, and 100 parts of xylitol.

[0011] A method for preparing any of the above-mentioned ginseng and astragalus oral liquids for spleen and lung qi deficiency specifically includes the following steps: Step 1, Ingredients: Weigh out 450-550 parts of Codonopsis pilosula, 450-550 parts of Astragalus membranaceus, and 50-150 parts of xylitol according to the mass ratio; The second step is extraction: Codonopsis pilosula and Astragalus membranaceus are heated with water and refluxed for extraction, and the extract is collected. The third step is filtration: the extract is filtered to obtain a clear filtrate; Step 4, concentration: Concentrate the filtrate to a fragrance paste with a relative density of 1.10-1.15 (50℃); Step 5, preparing the solution: Add xylitol to the fragrance paste and stir to dissolve to obtain the medicinal solution; Step 6, Fine filtration and filling: After fine filtration, the liquid medicine is filled into oral liquid containers; Step 7, sterilization: Terminal sterilization is performed on the filled oral liquid to obtain the ginseng and astragalus oral liquid for spleen and lung qi deficiency.

[0012] Preferably, in the second step, the amount of water added is 8-12 times the total mass of the medicinal materials, and the extraction is carried out by heating and reflux 2-3 times, each time for 1-2 hours.

[0013] Preferably, in the second step, after adding water, the sample is soaked for 30 minutes and then heated and refluxed for extraction.

[0014] Preferably, the filtration in the third step is performed using a plate and frame filter press or a 200-mesh sieve.

[0015] Preferably, in the fourth step, the filtrate is concentrated under reduced pressure at 60-70°C and a vacuum degree of -0.06 to -0.08 MPa to obtain a fragrance paste with a relative density of 1.10-1.15 (50°C).

[0016] Preferably, in the sixth step, the fine filtration is performed using a 0.45μm microporous membrane and then filled into a 10g oral liquid bottle.

[0017] Preferably, the terminal sterilization is circulating steam sterilization at 100°C for 30 minutes. After sterilization, the bottle is wiped, labeled, and boxed to obtain the Ginseng and Astragalus Oral Liquid for Spleen and Lung Qi Deficiency.

[0018] The application of a ginseng and astragalus oral liquid prepared by any of the above preparation methods for treating spleen and lung qi deficiency in the preparation of a drug for treating symptoms such as shortness of breath, weakness in the limbs, poor appetite, and loose stools caused by spleen and lung qi deficiency.

[0019] Compared with the prior art, the present invention provides a ginseng and astragalus oral liquid for spleen and lung qi deficiency, its preparation method, and its application, which have the following beneficial effects: 1. High safety and wide applicability: This application relates to a ginseng and astragalus oral liquid composed of two medicinal herbs, Codonopsis pilosula and Astragalus membranaceus, which is free of sucrose and preservatives; it creatively uses xylitol to replace rock sugar, which not only meets the need for flavoring, but more importantly, makes the product suitable for diabetic patients and people who need to control their sugar intake, significantly expanding the applicable population; at the same time, the complete elimination of preservatives eliminates consumers' concerns about chemical additives, making the product more natural and safe. 2. Improved portability and compliance: The traditional decoction has been improved into a 10g / vial oral liquid dosage form, which is accurate in dosage, easy to open, easy to carry and take, and greatly improves the medication compliance of patients, especially those who travel. 3. Advanced technology and stable quality: By optimizing extraction and concentration process parameters and combining fine filtration and terminal sterilization technologies, the product can still meet the regulations on microbial limits and stability within its shelf life even without preservatives. The entire preparation process is scientific and controllable, making it suitable for large-scale industrial production. 4. Preservation of efficacy: In the process of improving the dosage form, this invention strictly follows the compatibility and extraction principles of the original formula, ensuring that the improved oral liquid has the same "tonifying the spleen and benefiting the lungs" function as the original decoction. Detailed Implementation

[0020] The present invention will be further described below through specific embodiments, but the scope of protection of the present invention is not limited thereto.

[0021] Example 1: A method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency, specifically including the following steps: Step 1, Ingredients: Weigh out 450 parts of Codonopsis pilosula, 450 parts of Astragalus membranaceus, and 50 parts of xylitol according to the specified weight ratio; The second step is extraction: Codonopsis pilosula and Astragalus membranaceus are heated and refluxed with water. The amount of water added is 8 times the total mass of the medicinal materials. After adding water, soak for 30 minutes first. The reflux extraction is carried out twice, for 1 hour each time. The extract is then collected. The third step is filtration: the extract is filtered using a plate and frame filter press to obtain a clear filtrate. Step 4, concentration: The filtrate is concentrated under reduced pressure at 60℃ and a vacuum of -0.06MPa to a fragrance paste with a relative density of 1.10 (50℃); Step 5, preparing the solution: Add xylitol to the fragrance paste and stir to dissolve to obtain the medicinal solution; Step 6, Fine filtration and filling: Filter the liquid medicine through a 0.45μm microporous membrane and fill it into 10g oral liquid bottles; Step 7, sterilization: Terminal sterilization is performed on the filled oral liquid. Terminal sterilization is performed by flowing steam sterilization at 100°C for 30 minutes. After sterilization, the bottle is wiped, labeled, and boxed to obtain the Ginseng and Astragalus Oral Liquid for Spleen and Lung Qi Deficiency.

[0022] The application of Ginseng and Astragalus Oral Liquid for treating spleen and lung qi deficiency in the preparation of medicines for treating symptoms such as shortness of breath, weakness in the limbs, poor appetite, and loose stools caused by spleen and lung qi deficiency.

[0023] Example 2: A method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency, specifically including the following steps: Step 1, Ingredients: Weigh out 550 parts of Codonopsis pilosula, 550 parts of Astragalus membranaceus, and 150 parts of xylitol according to the specified weight ratio; The second step is extraction: Codonopsis pilosula and Astragalus membranaceus are heated and refluxed with water. The amount of water added is 12 times the total mass of the medicinal materials. After adding water, soak for 30 minutes first. The heating and reflux extraction is carried out 3 times, 2 hours each time. The extract is then collected. The third step is filtration: the extract is filtered through a 200-mesh sieve to obtain a clear filtrate; Step 4, concentration: The filtrate is concentrated under reduced pressure at 70℃ and a vacuum of -0.08MPa to a fragrance paste with a relative density of 1.15 (50℃); Step 5, preparing the solution: Add xylitol to the fragrance paste and stir to dissolve to obtain the medicinal solution; Step 6, Fine filtration and filling: Filter the liquid medicine through a 0.45μm microporous membrane and fill it into 10g oral liquid bottles; Step 7, sterilization: Terminal sterilization is performed on the filled oral liquid. Terminal sterilization is performed by flowing steam sterilization at 100°C for 30 minutes. After sterilization, the bottle is wiped, labeled, and boxed to obtain the Ginseng and Astragalus Oral Liquid for Spleen and Lung Qi Deficiency.

[0024] Example 3: A method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency, specifically including the following steps: Step 1, Ingredients: Weigh out 5000g of Astragalus membranaceus and 5000g of Astragalus membranaceus according to the mass ratio, and wash them; The second step is extraction: Codonopsis pilosula and Astragalus membranaceus are heated and refluxed with water. The amount of water added is 10 times the total mass of the medicinal materials. After adding 100L of purified water, soak for 30 minutes, heat and reflux for 1.5 hours, collect the extract, add 8 times the amount (80L) of purified water for the second time, reflux for 1 hour, and collect the extract. The third step is filtration: combine the two extracts and filter them through a 200-mesh sieve to obtain a clear filtrate; Step 4, concentration: The filtrate is concentrated under reduced pressure at 65℃ and a vacuum degree of -0.07MPa to 6000g of fragrance paste with a relative density of 1.12 (50℃); Step 5, Solution preparation: Add 1000g of xylitol to the fragrance paste, stir to dissolve, transfer to a solution preparation tank, add purified water to make up to 10000g, stir evenly to obtain the medicinal solution; Step 6, Fine filtration and filling: The medicine solution is filtered using a 0.45μm microporous membrane and filled into 10g oral liquid bottles, for a total of 1000 bottles; Step 7, sterilization: Terminal sterilization is performed on the filled oral liquid. Terminal sterilization is performed by flowing steam sterilization at 100°C for 30 minutes. After cooling, the outer wall of the bottle is wiped dry, a label is affixed, and the product is packaged to obtain the Ginseng and Astragalus Oral Liquid for Spleen and Lung Qi Deficiency.

[0025] The embodiments described above are some, but not all, embodiments of the present invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

Claims

1. A ginseng and astragalus oral liquid for spleen and lung qi deficiency, characterized in that, The raw materials of the ginseng and astragalus oral liquid for spleen and lung qi deficiency are formulated in the following proportions by weight: 450-550 parts of codonopsis, 450-550 parts of astragalus, and 50-150 parts of xylitol.

2. The ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 1, characterized in that, The raw materials for the ginseng and astragalus oral liquid for spleen and lung qi deficiency are formulated in the following proportions by weight: 500 parts of codonopsis, 500 parts of astragalus, and 100 parts of xylitol.

3. A method for preparing the ginseng and astragalus oral liquid for spleen and lung qi deficiency as described in claim 1 or 2, characterized in that, Specifically, the steps include the following: Step 1, Ingredients: Weigh out 450-550 parts of Codonopsis pilosula, 450-550 parts of Astragalus membranaceus, and 50-150 parts of xylitol according to the mass ratio; The second step is extraction: Codonopsis pilosula and Astragalus membranaceus are heated with water and refluxed for extraction, and the extract is collected. The third step is filtration: the extract is filtered to obtain a clear filtrate; Step 4, concentration: Concentrate the filtrate to a fragrance paste with a relative density of 1.10-1.15 (50℃); Step 5, preparing the solution: Add xylitol to the fragrance paste and stir to dissolve to obtain the medicinal solution; Step 6, Fine filtration and filling: After fine filtration, the liquid medicine is filled into oral liquid containers; Step 7, sterilization: Terminal sterilization is performed on the filled oral liquid to obtain the ginseng and astragalus oral liquid for spleen and lung qi deficiency.

4. The method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 3, characterized in that, In the second step, the amount of water added is 8-12 times the total mass of the medicinal materials, and the extraction is carried out by heating and reflux 2-3 times, each time for 1-2 hours.

5. The method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 3, characterized in that, In the second step, after adding water, soak for 30 minutes, and then heat and reflux to extract.

6. The method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 3, characterized in that, The filtration in the third step is performed using a plate and frame filter press or a 200-mesh sieve.

7. The method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 3, characterized in that, In the fourth step, the filtrate is concentrated under reduced pressure at 60-70℃ and a vacuum degree of -0.06 to -0.08MPa to obtain a fragrance paste with a relative density of 1.10-1.15 (50℃).

8. The method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 3, characterized in that, In the sixth step, fine filtration is performed using a 0.45μm microporous membrane and then filled into a 10g oral liquid bottle.

9. A method for preparing a ginseng and astragalus oral liquid for spleen and lung qi deficiency according to claim 3, characterized in that, The terminal sterilization is a circulating steam sterilization at 100°C for 30 minutes. After sterilization, the bottle is wiped, labeled, and boxed to obtain the Ginseng and Astragalus Oral Liquid for Spleen and Lung Qi Deficiency.

10. The use of the ginseng and astragalus oral liquid prepared according to any one of the preparation methods of claims 3-9 in the preparation of a medicine for treating symptoms such as shortness of breath, weakness of limbs, poor appetite, and loose stools caused by spleen and lung qi deficiency.