Applications of circPDK1

By detecting the expression level of circPDK1 in esophageal cancer tissues and utilizing its encoded peptide PDK1-241aa, the problem of the lack of effective biomarkers for esophageal cancer was solved, enabling accurate detection and prognostic evaluation of esophageal cancer and significantly improving patient survival outcomes.

CN121320543BActive Publication Date: 2026-06-16KUNMING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
KUNMING MEDICAL UNIVERSITY
Filing Date
2025-12-02
Publication Date
2026-06-16

AI Technical Summary

Technical Problem

The lack of effective biomarkers and therapeutic targets for esophageal cancer in existing technologies leads to poor patient prognosis, and there is limited research on circRNA in esophageal cancer.

Method used

We developed a reagent specifically for detecting the expression level of circPDK1, which is significantly upregulated in esophageal cancer tissues and encodes the peptide PDK1-241aa. By detecting its expression level, we prepared products for detecting esophageal cancer and evaluating its prognosis.

Benefits of technology

circPDK1 and its encoded peptide PDK1-241aa significantly promote the proliferation and migration of esophageal cancer cells. Knockdown of circPDK1 can inhibit the growth of esophageal cancer cells. Esophageal cancer patients with low expression have longer survival times, providing new directions for detection and treatment.

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Abstract

The application relates to the field of biological medicine, and protects the application of circPDK1, and particularly relates to the application of a reagent for specifically detecting circPDK1 in the preparation of a product for detecting esophageal cancer or evaluation of the prognosis thereof. The application protects the application of circular RNA in the preparation of a product for detecting esophageal cancer, wherein the circular RNA is circPDK1, and the nucleotide sequence is shown as SEQ ID NO:1. Experiments prove that circPDK1 is highly expressed in esophageal cancer tissues, promotes the growth, proliferation and migration of esophageal cancer cells, promotes the occurrence of esophageal cancer, and also proves that knocking down the circular RNA can significantly inhibit the growth, proliferation and migration of esophageal cancer tumors, and the average survival time of an esophageal cancer patient with low expression of circPDK1 is longer than that of a patient with high expression, thereby providing a new research direction for esophageal cancer detection, treatment and prognosis.
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