Magnetically coupled vascular occlusion system

Abstract

The present application relates to a magnetically coupled vascular occlusion system having opposite distal and proximal ends, the vascular occlusion system comprising: an occlusion member made of shape memory polymer foam, having a compressed loaded state and a fully expanded preset state, the occlusion member having a proximal end with a first connector; the intervention catheter is used for containing the blocking piece in the loading state; the delivery shaft is arranged in the intervention catheter in a sliding and penetrating mode and located on the near-end side of the plugging piece, the delivery shaft provides abutting force towards the far-end side in the releasing process of the plugging piece, a magnetic suction head is arranged at the far end of the delivery shaft, and the magnetic suction head is in detachable magnetic coupling with the first connector. Through the structural improvement of the plugging piece and the mutual cooperation of the plugging piece and the delivery shaft, detachable magnetic coupling of supports of the plugging piece and the delivery shaft can be realized, the operation is more convenient, no additional control part needs to be configured, the accurate positioning of the plugging piece is further improved, and the treatment effect is ensured.

Description

Technical Field

[0001] This application relates to the field of vascular interventional therapy, specifically to a magnetically coupled vascular occlusion system. Background Technology

[0002] Shape memory polymers (SMPs) are a class of stimuli-responsive smart polymers that can recover their pre-defined shape from a temporary deformed state in response to external stimuli (such as temperature and moisture). This property stems from their unique two-phase structure, consisting of a stationary phase that maintains the permanent shape and a reversible phase that imparts temporary deformation capability. Their shape memory temperature, recovery rate, mechanical strength, and degradation period can be controlled by adjusting the raw material ratio, crosslinking degree, and molecular chain structure, thereby meeting the application needs of various fields. SMPs have attracted significant attention in the biomedical field, particularly in minimally invasive interventional therapies.

[0003] To ensure the device maintains a stable temporary deformation state during delivery and to prevent premature expansion or displacement, the device and delivery system are typically secured using mechanical locking, threaded connections, or thermoforming. While these connection methods meet the stability requirements during delivery, the release and detachment process at the lesion site is cumbersome and demands a high level of operator skill.

[0004] The cumbersome nature of the release and detachment process may not only prolong the operation time and increase the operator's workload, but may also lead to deviations in the timing of device expansion and positioning. Summary of the Invention

[0005] This application provides a magnetically coupled vascular occlusion system that is easy to disengage, further reducing the difficulty of surgical procedures.

[0006] This application discloses a magnetically coupled vascular occlusion system having opposing distal and proximal ends, the vascular occlusion system comprising: The sealing component is made of shape memory polymer foam and has a compressed loaded state and a fully expanded preset state. The sealing component has a first connector at the proximal end. An interventional catheter for receiving the occlusion device in its loaded state; A delivery shaft is slidably inserted within the interventional catheter and located on the proximal side of the occlusion element. The delivery shaft provides a counterforce toward the distal side during the release of the occlusion element. The distal end of the delivery shaft is provided with a magnetic suction head, which is detachably magnetically coupled to the first connector.

[0007] Several alternative methods are provided below, but they are not intended as additional limitations on the overall solution above. They are merely further additions or optimizations. Provided there are no technical or logical contradictions, each alternative method can be combined individually with respect to the overall solution above, or multiple alternative methods can be combined with each other.

[0008] In one embodiment, the magnetic suction head includes a permanent magnet; or the magnetic suction head includes an electromagnet and the delivery shaft is provided with a drive circuit that supplies power to the electromagnet.

[0009] In one embodiment, the outer edge of the magnetic head is provided with a positioning ring, which surrounds to form a positioning area. When the magnetic head is combined with the first connector, the first connector is placed into the positioning area.

[0010] In one embodiment, the distal end of the sealing member has a second connector, and the interior of the sealing member is provided with a pull wire connecting the first connector and the second connector; In the preset state, the plugging component has the pull wire taut.

[0011] In one embodiment, a barrier net is fixed to the distal end of the second connector. The barrier net has a compressed state and an extended state. In the compressed state, it is located in the interventional catheter, and in the extended state, it is exposed to the interventional catheter for anchoring to the implantation site.

[0012] In one embodiment, the barrier net includes multiple unit arms distributed around the delivery axis, the number of which is three to eight. Each unit arm is arranged in a loop, and from the axial perspective of the delivery axis, each unit arm does not overlap with the others in the unfolded state.

[0013] In one embodiment, a heating element is arranged along the pull wire, and a power supply circuit connected to the heating element is provided in the delivery shaft; When the first connector and the magnetic head are attracted to each other, the power supply circuit is connected to the heating element; when the first connector and the magnetic head are separated, the power supply circuit is disconnected from the heating element.

[0014] In one embodiment, the first connector includes a first inner terminal and a first outer terminal surrounding the outer periphery of the first inner terminal, wherein the proximal portion of the plug is clamped and fixed between the first inner terminal and the first outer terminal and is insulated from both. The heating element is a resistance wire arranged back and forth along the pull wire, and the two ends of the resistance wire are electrically connected to the first inner terminal and the first outer terminal.

[0015] In one embodiment, the resistance wire is in circuit communication with the second connector and is folded back at the distal end of the sealing member via the second connector.

[0016] In one embodiment, the magnetic head includes a second inner terminal and a second outer terminal surrounding the outer periphery of the second inner terminal, with an insulating layer between the second inner terminal and the second outer terminal, and the power supply circuit is electrically connected to the second inner terminal and the second outer terminal; When the first connector and the magnetic head are attracted to each other, the first inner terminal and the second inner terminal are in contact with each other and the circuit is connected, and the first outer terminal and the second outer terminal are in contact with each other and the circuit is connected. At least one of the second inner terminal and the second outer terminal is a permanent magnet, and the magnetic attraction is applied to the one of the first inner terminal and the first outer terminal that are radially matched.

[0017] This application also provides an occlusion device for occluding blood vessels, which is made of shape memory polymer foam. The occlusion device has a first connector at the proximal end and a second connector at the distal end. The occlusion device has a pull wire inside that connects the first connector and the second connector.

[0018] In one embodiment, the sealing member has a compressed loaded state and a fully expanded preset state, wherein the pull wire is taut in the preset state.

[0019] In one embodiment, a heating element is disposed inside the pull wire for heating the sealing member.

[0020] This application also provides a vascular occlusion component, comprising: The sealing component is made of shape memory polymer foam and has a compressed loaded state and a fully expanded preset state. The sealing component has a first connector at the proximal end. A delivery shaft provides a counterforce toward the distal end during the release of the sealing element. The distal end of the delivery shaft is provided with a magnetic head, which is detachably magnetically coupled to the first connector.

[0021] This application improves the structure of the occlusion component and its interaction with the delivery axis, enabling detachable magnetic coupling between the two stents. This makes operation more convenient and eliminates the need for additional control components. Furthermore, the expansion timing of the occlusion component can be controlled by a heat-generating cable, further improving the precise positioning of the occlusion component and ensuring the treatment effect. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the conventional technology, the drawings used in the description of the embodiments or the conventional technology will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram illustrating the delivery of an occlusive device within a blood vessel in the prior art. Figure 2 for Figure 1 A schematic diagram showing the displacement of the occluder from its implantation position due to blood flow after it is released; Figure 3 This is a schematic diagram of a vascular occlusion system in one embodiment of this application; Figure 4 for Figure 3 A schematic diagram of the expanded sealing component; Figure 5 This is a schematic diagram of a vascular occlusion system in another embodiment of this application; Figure 6 for Figure 5 A schematic diagram of the expanded sealing component; Figure 7 This is a schematic diagram of the magnetic coupling part and its end face of the vascular occlusion system in one embodiment of this application; Figure 8 for Figure 7 Schematic diagram of the magnetic coupling part; Figure 9 This is a schematic diagram of the circuit principle for the heating element at the pull wire location in one embodiment of this application; Figure 10 This is a schematic diagram of the circuit principle for the heating element at the pull wire location in another embodiment of this application; Figure 11 This is a schematic diagram of the occlusion component of a vascular occlusion system in another embodiment of this application; Figure 12 This is a schematic diagram of a barrier net viewed from an axial perspective in one embodiment of this application; Figure 13 This is a schematic diagram of the barrier net from an axial perspective in another embodiment of this application; Figure 14 This is a schematic diagram of the barrier net from an axial perspective in another embodiment of this application; Figure 15 This is a schematic diagram of the barrier net from an axial perspective in another embodiment of this application; Figure 16 for Figure 5 A schematic diagram of interventional delivery using the central artery occlusion system; Figure 17 for Figure 16A schematic diagram showing the occlusion element exposed after the interventional catheter is inserted; Figure 18 for Figure 17 A schematic diagram showing the occlusion element expanding to the implanted state and decoupled from the delivery axis; Figure 19 To adopt Figure 11 A schematic diagram of interventional delivery of a vascular occlusion system with an occlusive device; Figure 20 for Figure 19 A schematic diagram showing the barrier net exposed to the interventional catheter and in an deployed state; Figure 21 for Figure 20 A schematic diagram showing the occlusion element exposed after the interventional catheter is inserted; Figure 22 for Figure 21 A schematic diagram showing the occlusion element expanding to the implanted state and decoupled from the delivery axis.

[0024] The component labels are as follows: 100. Blood vessel; 200. Occlusion component; 210. First connector; 211. First inner terminal; 212. First outer terminal; 220. Second connector; 230. Pull wire; 231. Core wire; 232. Resistance wire; 300. Interventional catheter; 310. Imaging marker; 400. Delivery shaft; 410. Magnetic head; 411. Second inner terminal; 412. Insulating layer; 413. Second outer terminal; 414. Positioning ring; 500. Barrier net; 510. Unit arm; 511. Imaging marker. Detailed Implementation

[0025] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0026] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on the other component or there may be an intermediate component. When a component is considered to be "connected to" another component, it can be directly connected to the other component or there may be an intermediate component present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application's specification are for illustrative purposes only and do not represent the only possible implementation.

[0027] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0028] Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used in this application includes any and all combinations of one or more of the associated listed items.

[0029] See Figure 1 , Figure 2 When polyurethane SMP foam is used as the occlusion element 200, it is generally pre-compressed and loaded into the interventional catheter 300 and delivered in the body through the interventional catheter 300. The delivery shaft 400 extends within the interventional catheter 300 with its distal end adjacent to the occlusion element 200. After reaching the predetermined implantation position, the interventional catheter 300 is held in the current position, and the delivery shaft 400 is pushed distally, thereby pushing the occlusion element 200 out of the distal end of the interventional catheter 300 and exposing it within the blood vessel 100. However, the occlusion element 200 does not immediately expand to occlude and anchor itself to the blood vessel; it may further expand along the blood flow. Figure 2 The middle arrow points towards the distal end, deviating from the preset implantation position.

[0030] To address this problem, one embodiment of this application provides a vascular occlusion system. The vascular occlusion system has a relative distal end and a proximal end. The proximal end generally refers to the side adjacent to the operator (e.g., a doctor), and the distal end is the side relatively far away. Along the intervention path, each component itself has a relative distal end and a proximal end. When the proximal end and the distal end are a straight line, the axial direction is also determined, and correspondingly, the radial direction perpendicular to the axial direction and the circumferential direction arranged around the axial direction are also determined. When used to refer to a structure, the term "end" in this text means the endpoint of the structure or a point or region in that lateral direction, or a specific structure connected to that point or region.

[0031] See Figure 3 , Figure 4The vascular occlusion system of this embodiment includes an occlusion element 200, an interventional catheter 300, and a delivery shaft 400. The delivery shaft 400 and the occlusion element 200 are coupled by a detachable magnetic coupling, meaning that the two can be attracted to each other by magnetic force. The real-time position of the occlusion element 200 can be controlled by the delivery shaft 400. After positioning and related operations are completed, the occlusion can be completed by eliminating the magnetism or by the relative movement between them. No additional detachment drive components are required, making the structure simple and easy to operate.

[0032] Based on the occlusion element 200 itself, it can be understood that an embodiment of this application also provides an occlusion element 200 for vascular occlusion, and based on both the occlusion element 200 and the delivery shaft 400, it can be understood that an embodiment of this application also provides a vascular occlusion assembly.

[0033] Regarding the sealing component 200 itself, it can be made of shape memory polymer foam. Its material and preparation can be implemented using existing technologies, such as polyurethane memory foam. At relatively low temperatures, it can maintain its current molded shape and expand to a preset state when exposed to water and / or affected by body temperature. For example, it can be based on the polyurethane shape memory foam disclosed in Chinese patent document CN120679011A, using macromolecular polyols, diisocyanates, chain extenders containing disulfide bonds, other small molecule chain extenders, and acrylate end-capping agents to prepare a polyurethane acrylate prepolymer; then, the polyurethane acrylate prepolymer, foaming agent, foaming aid, and photoinitiator are mixed evenly as a foaming liquid, and the foaming liquid is sequentially photocured and foamed to obtain the polyurethane shape memory foam, whose expansion rate can be 100-150 times.

[0034] The overall shape of the sealing component 200 is not strictly limited and can be adapted to the physiological structure of the part to be sealed. For example, after full expansion, it can be in the shape of a block, specifically a cylinder, a frustum, a sphere, an ellipsoid, or even various irregular shapes.

[0035] The interventional catheter 300 is used to accommodate the occlusion element 200 in its loaded state. The interventional catheter 300 can be made of existing materials and is suitable for interventional delivery. The inner wall of the interventional catheter 300 may have a lubricating layer. An operating handle may be provided at the proximal end of the interventional catheter 300 as needed. The operating handle can also operate the delivery shaft 400 and adopt an existing transmission structure. The interventional catheter 300 may also be equipped with a bending mechanism to adapt to complex and tortuous access paths. The distal end of the interventional catheter 300 can be changed by a corresponding drive mechanism on the operating handle. For real-time position monitoring, the distal end of the interventional catheter 300 may have a contrast marker 310.

[0036] The occlusion element 200 has a porous internal structure, allowing its volume to be changed through compression to suit loading and transcatheter delivery. The occlusion element 200 expands within the body and occupies space at the implantation site, achieving a sealing effect. During use, it generally includes the following components in ascending order of relative volume in common configurations: The compressed loading state, for example, being housed in the interventional catheter 300 for interventional delivery; In the case of implantation with restricted expansion, taking the implantation within a blood vessel 100 as an example, "restricted" can be understood as being slightly compressed under the action of the blood vessel wall. Because it has a tendency to expand further, there is an interaction force between it and the blood vessel wall, which keeps it taut at the implantation site. The fully expanded preset state can be understood as the maximum volume that the sealing component 200 can expand to when there is no compressive force around it.

[0037] In terms of volume, the preset state can be 50 to 100 times the loaded state. In some cases, the axial length of the sealing component remains basically unchanged in the preset state and the loaded state, only expanding radially outward, and the outer diameter can be expanded to about 10 times.

[0038] The delivery shaft 400 can generally be a guide wire or other means that can bear axial pushing force. In use, the delivery shaft 400 slides through the interventional catheter 300 and is located on the proximal side of the occlusion member 200. During the release of the occlusion member 200, the delivery shaft 400 provides a resisting force to the distal side. In order to achieve magnetic coupling, the distal end of the delivery shaft 400 is provided with a magnetic suction head 410, and the proximal end of the occlusion member 200 is provided with a first connector 210. The magnetic suction head 410 and the first connector 210 are detachable magnetically coupled.

[0039] The magnetic head 410 itself or a part thereof may be a permanent magnet. The first connector 210 itself or a part thereof may be made of metal and may respond to the magnetic field and attract each other with the magnetic head 410. Alternatively, the magnetic head 410 may also generate a magnetic field by means of an electromagnet. In this case, a drive circuit that supplies power to the electromagnet is provided in the delivery shaft 400. The circuit controls the existence or elimination of the magnetic field. The electromagnet and the drive circuit itself may be implemented in combination with existing technology.

[0040] See Figure 5 , Figure 6 In another embodiment of the vascular occlusion system of this application, the distal end of the occlusion member 200 is provided with a second connector 220, and the interior of the occlusion member 200 is provided with a pull wire 230 connecting the first connector 210 and the second connector 220.

[0041] At least one of the first connector 210, the second connector 220, and the pull wire 230 may have a radiopaque marking, or may be partially or entirely made of radiopaque material, serving as a radiopaque marking. The pull wire 230 may be made of metal or composite materials. In the preset state of the occlusion component 200, the taut pull wire 230 can limit axial deformation, maintain the expected radial dimension, and ensure sufficient friction with the surrounding tissue at the implantation site to ensure positioning effectiveness. In some cases, the pull wire 230 is also taut within the occlusion component 200 in the loaded state.

[0042] The first connector 210 and the second connector 220 can be metal rings. During installation, the corresponding parts of the sealing component 200 are radially compressed, and then the metal rings are fitted and tightened for fixation. The end of the pull wire 230 can be tightened and fixed together with the first connector 210 and the second connector 220, or it can be bonded or welded to the first connector 210 and the second connector 220 for fixation. The pull wire 230 can be pre-embedded during the preparation of the sealing component 200, or it can be inserted into the sealing component 200 by drilling a hole in the later stage of the sealing component 200 molding.

[0043] The existing SMP foam formulation used to prepare the sealing component 200 can adjust the glass transition temperature (Tg) of the foam by adjusting the molar ratio of raw materials, thereby adjusting the expansion initiation characteristics. Although the internal environment temperature is lower than Tg, water in the blood can penetrate into the foam, causing Tg to decrease. Upon contact with blood, expansion can occur, and expansion may even be initiated prematurely in the catheter, hindering delivery.

[0044] See further Figures 7-10 In order to precisely control the timing of expansion initiation, in a vascular occlusion system of this application, a heating element is arranged along the pull wire 230, and a power supply circuit connected to the heating element is provided in the delivery shaft 400. When the first connector 210 and the magnetic suction head 410 are attracted together, the power supply circuit is connected to the heating element, and when the first connector 210 and the magnetic suction head 410 are attracted together, the power supply circuit is disconnected from the heating element.

[0045] This implementation cleverly combines magnetic coupling with the switching on and off of the power supply circuit. Temperature changes control the expansion initiation timing of the sealing component 200. For example, in scenarios requiring precise positioning or long-distance delivery, SMP foam with a higher Tg (temperature gradient) can be prepared, such as 45℃~62℃, or around 60℃. Under simple body temperature, the expansion speed is slightly slower, providing sufficient operation time for the surgery. For safety, an upper limit for the heating temperature can be set, such as no higher than 50℃, or no higher than 45℃. At this temperature, combined with the water absorption and permeation of the sealing component 200, it can expand rapidly, for example, expanding to the implantable state in 15s~30s to complete in-body positioning. To control the temperature, the energizing time and power can be set based on empirical data. Furthermore, a temperature detection element can be configured to detect and provide feedback on the temperature signal around the sealing component 200 in real time. In this embodiment, the heating element extends through the sealing component 200 from its proximal end, ensuring uniform heating of all parts of the sealing component 200 along its axial direction and better synchronization of the expansion timing.

[0046] Figure 7 To ensure magnetic coupling and stable circuit conduction, a positioning ring 414 may be provided on the outer edge of the magnetic suction head 410. The positioning ring 414 forms a positioning area around the magnetic suction head 419 and the first connector 210. When the magnetic suction head 419 is engaged with the first connector 210, the first connector 210 is placed in the positioning area to avoid unexpected radial misalignment and ensure correct circuit connection. The positioning ring 414 may be made of elastic material and fitted around the outer periphery of the first connector 210 to provide a sealing effect and prevent blood or other substances from penetrating into the mating surface between the magnetic suction head 410 and the first connector 210.

[0047] To achieve the circuit layout, the first connector 210 includes a first inner terminal 211 and a first outer terminal 212 surrounding the outer periphery of the first inner terminal 211, wherein the proximal portion of the sealing member 200 is clamped and fixed between the first inner terminal 211 and the first outer terminal 212 radially, thereby insulating them from each other and providing a sealing function.

[0048] The magnetic head 410 includes a second inner terminal 411 and a second outer terminal 413 surrounding the outer periphery of the second inner terminal 411. An insulating layer 412 is provided between the second inner terminal 411 and the second outer terminal 413. The power supply circuit is electrically connected to the second inner terminal 411 and the second outer terminal 413.

[0049] When the first connector 210 and the magnetic head 410 are attracted together, the first inner terminal 211 and the second inner terminal 411 are in contact with each other and the circuit is connected, the first outer terminal 212 and the second outer terminal 413 are in contact with each other and the circuit is connected, and the part of the sealing member 200 that is clamped and fixed corresponds to the insulating layer 412 and is close to each other to further achieve sealing and insulation.

[0050] Corresponding to the magnetic coupling, at least one of the second inner terminal 411 and the second outer terminal 413 is a conductive permanent magnet, which takes into account both circuit connection and magnetic coupling. For example, the second inner terminal 411 is a permanent magnet and magnetic attraction is applied to the first inner terminal 211.

[0051] See Figure 9 The heating element can be a resistance wire arranged in a reciprocating pattern, and the reciprocating resistance wire itself constitutes a pull wire 230. The two ends of the resistance wire are electrically connected to the first inner terminal 211 and the first outer terminal 212. The resistance wire can be bent to achieve the reciprocating motion, or the second connector 220 can be a conductive component, with the resistance wire and the second connector 220 connected in a circuit. The resistance wire is also bent back at the far end of the sealing member 200 through the second connector 220, ensuring the continuity of the circuit.

[0052] See Figure 10 The pull wire 230 includes a core wire 231 and a resistance wire 232 wound around the outer periphery of the core wire 231. The resistance wire 232 is wound in parallel and folds back at the far end to form a circuit. The two ends of the resistance wire 232 extend to the near end and are respectively connected to the first inner terminal 211 and the first outer terminal 212.

[0053] The outer periphery of the resistance wire in each implementation can be further coated to provide a fixing effect and take into account the overall mechanical properties.

[0054] See Figure 11 In another embodiment of this application, a barrier net 500 is fixed to the distal end of the second connector 220. The barrier net 500 may be made of shape memory alloy material and has a relative compressed state and an unfolded state. In the compressed state, it is located in the interventional catheter 300, and in the unfolded state, it is exposed to the distal end of the interventional catheter 300. It can be anchored in the blood vessel to define the implantation position of the occlusion member 200.

[0055] Further integration Figures 12-15 The barrier net 500 includes multiple unit arms 510 distributed around the delivery axis. The number of unit arms 510 is three to eight, for example, four or five. From an axial perspective along the delivery axis 400, the shape of the unit arms 510 can be... Figure 12 The S-shape in the middle, Figure 13 Straight rod shape, or Figure 14 , Figure 15 The middle unit arm 510 is arranged in a ring shape. To avoid unnecessary interference, the unit arms 510 do not overlap in the axial viewing angle when deployed. Each unit arm 510 has a developing mark 511 on its outermost side and is welded to the second connector 220 on its innermost side. In the compressed state, the developing mark 511 is located at the farthest end of the entire barrier net 500. Whether in the intervention delivery state or the deployed state, the position and attitude of the barrier net 500 can be observed through imaging equipment.

[0056] See further Figures 16-18 An embodiment of this application uses Figure 5 Taking the vascular occlusion system as an example, the interventional delivery process is as follows: Figure 16 In this procedure, the interventional catheter 300, carrying the occlusion element 200 and the delivery shaft 400, is inserted into the blood vessel 100. The magnetic suction head 410 and the first connector 210 are mutually attracted and connected. The positions of the first connector 210, the second connector 220, and the imaging marker 310 can be observed in real time through imaging equipment to guide the surgical procedure.

[0057] Figure 17 In this process, the occlusion element 200 is exposed at the distal end of the interventional catheter 300 under the push of the delivery shaft 400. At this time, the occlusion element 200 has not yet started to expand, which makes it easy to adjust its position as needed.

[0058] Figure 18 In the process, the occlusion element 200 expands to the implantation state. This expansion can be initiated by body temperature and blood environment or by heating with an electric current through a pull wire. After expansion, the occlusion element 200 is anchored within the blood vessel 100. Then, the interventional catheter 300 can be used to press against the occlusion element 200 distally and simultaneously retract the delivery shaft 400 proximally, so that the magnetic suction head 410 is decoupled from the first connector 210 and stored in the interventional catheter 300. Subsequently, the delivery shaft 400 is withdrawn from the body along with the interventional catheter 300.

[0059] See further Figures 19-22 Another embodiment of this application uses Figure 11 Taking the vascular occlusion system as an example, the interventional delivery process is as follows: Figure 19 In this procedure, the interventional catheter 300, carrying the occlusion element 200 and delivery shaft 400, is inserted into the blood vessel 100. The magnetic suction head 410 and the first connector 210 are mutually attracted and connected. The compressed barrier net 500 is also housed within the interventional catheter 300. The positions of the first connector 210, the second connector 220, and the contrast markers 310 and 511 can be observed in real time using imaging equipment to guide the surgical procedure. Alternatively, the magnetic suction head 410 may also be equipped with a contrast marker.

[0060] In this embodiment, a pull wire 230 is provided between the first connector 210 and the second connector 220, and a heating element is also arranged along the pull wire 230. The power supply forms a circuit with the heating element through the delivery shaft 400, the magnetic head 410, and the first connector 210 to provide power for heating.

[0061] Figure 20In this process, the delivery axis 400 is moved distally relative to the interventional catheter 300, or the interventional catheter 300 is moved proximally relative to the delivery axis 400, so that the barrier net 500 is exposed to the interventional catheter 300. The barrier net 500 is then switched to an unfolded state by its own deformation and anchored within the blood vessel 100.

[0062] Figure 21 In the middle, the interventional catheter 300 is further withdrawn proximally, and the occlusion element 200 is exposed at the distal end of the interventional catheter 300. At this time, the occlusion element 200 has not yet started to expand.

[0063] Figure 22 In the process, electricity is applied to the resistance wire, and the temperature is raised to about 45 degrees Celsius to heat the occlusion component 200. The timing of the expansion can be precisely controlled. After the occlusion component 200 expands, it and the barrier net 500 are anchored in the blood vessel 100. Then, the interventional catheter 300 can be used to push against the occlusion component 200 distally and simultaneously withdraw the delivery shaft 400 proximally, so that the magnetic suction head 410 is decoupled from the first connector 210 and stored in the interventional catheter 300. Subsequently, it is withdrawn out of the body along with the interventional catheter 300.

[0064] The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as the combination of these technical features does not contradict each other, it should be considered to be within the scope of this specification. When technical features of different embodiments are embodied in the same drawing, it can be regarded as the drawing also disclosing examples of combinations of the various embodiments involved.

[0065] The above embodiments merely illustrate several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the patent protection scope of this application should be determined by the appended claims.

Claims

1. A magnetically coupled vaso-occlusive system having opposite distal and proximal ends, characterized by, The vascular occlusion system comprises: a closure member made of a shape memory polymer foam, having a compressed loading state and a fully expanded preset state, the closure member having a proximal end with a first connector; an intervention catheter for accommodating the closure member in the loading state; a delivery shaft slidingly arranged in the intervention catheter and located at the proximal end side of the closure member, the delivery shaft providing a distal abutting force during release of the closure member, the distal end of the delivery shaft being provided with a magnetic head, the magnetic head and the first connector being releasably magnetically coupled.

2. The vascular occlusion system of claim 1, wherein, The magnetic head comprises a permanent magnet; or the magnetic head comprises an electromagnet and the delivery shaft is provided with a drive circuit for supplying power to the electromagnet.

3. The vascular occlusion system of claim 1, wherein, The outer edge of the magnetic head is provided with a positioning ring, the positioning ring forming a positioning area, when the magnetic head is combined with the first connector, the first connector is placed in the positioning area.

4. The vascular occlusion system of claim 1, wherein, The distal end of the closure member is provided with a second connector, the interior of the closure member is provided with a pull wire connected between the first connector and the second connector; The pull wire is taut in the preset state of the closure member.

5. The vascular occlusion system of claim 4, wherein, The distal end side of the second connector is fixed with a barrier net, the barrier net having opposite compressed and expanded states, the compressed state being located in the intervention catheter, the expanded state being exposed to the intervention catheter for anchoring to the implantation position.

6. The vascular occlusion system of claim 5, wherein, The barrier net comprises a plurality of unit arms distributed around the axis of the delivery shaft, the number of unit arms being three to eight, each unit arm is itself arranged in a ring shape, and from the axial perspective of the delivery shaft, each unit arm does not overlap with each other in the expanded state.

7. The vascular occlusion system of claim 4, wherein, A heating element is arranged along the pull wire, and the delivery shaft is provided with an energy supply circuit connected to the heating element; When the first connector and the magnetic head are attracted to each other, the energy supply circuit is connected to the heating element, and when the first connector and the magnetic head are separated, the energy supply circuit is disconnected from the heating element.

8. The vascular occlusion system of claim 7, wherein, The first connector comprises a first inner terminal and a first outer terminal surrounding the outer periphery of the first inner terminal, wherein the proximal end of the closure member is clamped and fixed between the first inner terminal and the first outer terminal and is insulated from both terminals; The heating element is a resistance wire arranged back and forth along the pull wire, and the two ends of the resistance wire are electrically connected to the first inner terminal and the first outer terminal.

9. The vascular occlusion system of claim 8, wherein, The resistance wire is in circuit communication with the second connector and is folded back at the distal end of the closure member through the second connector.

10. The vascular occlusion system of claim 8, wherein, The magnetic head comprises a second inner terminal and a second outer terminal surrounding the outer periphery of the second inner terminal, and the second inner terminal and the second outer terminal are provided with an insulating layer therebetween, and the energy supply circuit is electrically connected to the second inner terminal and the second outer terminal; When the first connector and the magnetic head are attracted to each other, the first inner terminal and the second inner terminal are in contact with each other and the circuit is connected, and the first outer terminal and the second outer terminal are in contact with each other and the circuit is connected; At least one of the second inner terminal and the second outer terminal is a permanent magnet, and the magnetic attraction is applied to the one of the first inner terminal and the first outer terminal which matches the radial position.

Images